CINXE.COM

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class="banner-sub-title-seo">RNAscope™ Applications</h2></div><div class="content-container container newapplication"><div id="node-424701" class="node node-application node-promoted" about="/science/applications/research-areas/covid-19-coronavirus" typeof="sioc:Item foaf:Document"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs application-bxslider" id="myTab"><li><a href="/science/applications/research-areas/infectious-diseases">Infectious Diseases</a></li><li><a href="/science/applications/disease-areas/zika-virus-research">Zika Virus</a></li><li><a href="/science/applications/research-areas/hiv-siv">HIV & SIV</a></li><li class="active"><a href="/science/applications/research-areas/covid-19-coronavirus" class="active">COVID-19 Coronavirus</a></li></ul></div><div class="tab-content"><div id="tab0" class="tab-pane fade in active profile"><h1 class="top-profile">COVID-19 Coronavirus</h1><div class="sample-image"></div><div class="profile-content application_node_424701"><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p>COVID-19 (Coronavirus disease 2019) is caused by the positive stranded <strong>SARS-CoV-2 </strong>RNA virus in humans and is closely related to the bat-derived severe acute respiratory syndrome-like coronaviruses. Among the human viruses SARS-CoV-2 is most similar to SARS-CoV and MERS-CoV viruses that are responsible for the severe acute respiratory syndrome and middle eastern respiratory syndrome, respectively.</p><p> </p><p style="text-align:center;"><img alt="" src="/sites/default/files/CovidCorona.png" /></p><p> </p><p><strong>How can the RNAscope<span style="color: rgb(34, 34, 34); font-family: Calibri, sans-serif; font-size: 14.6667px;">™</span><strong> </strong>technology support COVID-19 research?</strong></p><p>The unparalleled sensitivity and specificity of the RNAscope<span style="color: rgb(34, 34, 34); font-family: Calibri, sans-serif; font-size: 14.6667px;">™</span> technology allows direct visualization of the virus and estimates the viral load in any tissue and cells with morphological context. This technology eliminates the need for the costly and time-consuming development of specific antibodies for newly identified gene targets or pathogens such as the COVID-19 SARS-CoV-2 virus. Additionally, the RNAscope technology can be combined with immunohistochemistry (IHC) on the same slide for detection of RNA and protein simultaneously. The RNAscope probe can detect the SARS-CoV-2 spike protein mRNA and does not detect other coronaviruses.</p><p> </p><ul><li>Visualize the SARS-Cov-2 viral RNA using the <strong>V-nCoV2019-S </strong>probe and detect viral replication with the <strong>V-nCoV2019-S sense </strong>probe.</li><li>Identify potentially vulnerable cell types by visualizing cellular receptor <strong>ACE2 </strong>and proteases such as<strong> TMPRESS , Cathepsin B </strong>and<strong> L </strong>which facilitate viral entry into the host cells.</li><li>Identify cellular sources of secreted cytokines such as <strong>IL-1β, IL-6, IL-8, TNFα</strong> and <strong>IL-10</strong> among others which can induce acute respiratory distress syndrome (ARDS) in severe COVID-19 patients.</li><li>Using the RNAscope or BaseScope<span style="color: rgb(34, 34, 34); font-family: Calibri, sans-serif; font-size: 14.6667px;">™</span> assays, any host or viral target gene can be identified to enhance our understanding of SARS-CoV-2 pathogenesis and assist in the development of vaccines and therapies.</li></ul></div></div></div><div class="view view-application view-id-application view-display-id-block_8 view-dom-id-7fcda7fac2f7b37358566a2cee1dc9d9"></div><div class="view view-application view-id-application view-display-id-block_9 view-dom-id-7a9ce52eb4d6751efa17367d763bbf8c"><div class="view-content"><style type="text/css"> .view-id-application.view-display-id-block_9 .row.immuno-watch { margin-top: 15px; margin-bottom: 15px; } </style></div></div></div><div class="sample-image"><div class="profile-bottom"></div></div><div class="spotlight"><div class="profile-bottom spot"><div><a href="https://asuragen.com/portfolio/armored-rna-quant-sars-cov-2-controls/"><img alt="" src="/sites/default/files/DW_ASU_Covid-Banner-1109x241.jpg" style="width: 100%; height: auto;" /></a></div><div class="classification application-table hiv-siv-table"><h2>RNAscope Catalog Probes Targeting COVID-19 Coronavirus: </h2><p>(Listed below are probes for manual RNAscope assay. Corresponding probes for automated assays are also available. )</p><div><table><thead><tr><th><p><strong>Target species & region</strong></p></th><th><p><strong>Cat. No & Probe Description</strong></p></th></tr></thead><tbody><tr><td><p>Specfic for SARS-CoV-2,<br />S gene encoding the spike protein</p></td><td><p><a href="https://acdbio.com/search/site/%252A848561%252A/cms/probes" style="line-height: 20.8px;">848561</a> RNAscope™ Probe - V-nCoV2019-S</p></td></tr><tr><td><p>Specfic for SARS-CoV-2,<br />Antisense strand of the S gene</p></td><td><p><a href="https://acdbio.com/search/site/%252A845701%252A/cms/probes" style="line-height: 20.8px;">845701</a> RNAscope™ Probe - V-nCoV2019-S-sense<br />(Note: Cannot be duplexed with the V-nCoV2019-S probe)</p></td></tr><tr><td><p>Specfic for SARS-CoV-2,<br />Antisense strand of the orf1ab gene</p></td><td><p><a href="https://acdbio.com/search/site/%252A859151%252A/cms/probes" style="line-height: 20.8px;">859151</a> RNAscope™ Probe- V-nCoV2019-orf1ab-sense<br />(Note: Can be duplexed with the V-nCoV2019-S probe)</p></td></tr><tr><td><p>ACE2,<br />Cellular receptor for SARS-CoV-2</p></td><td><p><a href="https://acdbio.com/search/site/%252A848151%252A/cms/probes" style="line-height: 20.8px;">848151</a> RNAscope™ Probe - Hs-ACE2</p></td></tr><tr><td><p>TMPRSS2,<br />Cellular serine protease and primes the spike protein (S) for cellular entry</p></td><td><p><a href="https://acdbio.com/search/site/%252A470341%252A/cms/probes" style="line-height: 20.8px;">470341</a> RNAscope™ Probe - Hs-TMPRSS2</p></td></tr></tbody></table></div><p><strong>To target other COVID-19 coronavirus strains or regions, ACD can design and manufacture <a href="http://acdbio.com/target-probes-made-order">MADE-TO-ORDER Probes</a>  in just 2 weeks. </strong></p><div class="img-container grid" id="pas-non-publications-2"><div class="row"><div class="col-md-12 grid"><div class="step-para"><div class="book_image_content"><div class="book-image-left"><img class="book_image" src="/sites/default/files/RNAscope-Sars-COVID-19_Flyer.jpg" /></div><div class="book-content-right"><p class="rna_manual_solutions">Download COVID-19 Flyer</p><div class="book_image_down"><a class="book_download_button" href="/system/files_force/RNAscope-Sars-COVID-19_Flyer.pdf?download=1">Download Flyer</a></div></div></div></div></div></div></div></div></div><div class="profile-bottom publication"><div class="profile-bottom spot"><h2>COVID-19 research using the RNAscope technology</h2><ul><li><p>Researchers from Jay K. Kolls, MD's lab at the Center for Translational Research in Infection and Inflammation, Tulane School of Medicine have extensively used RNAscope for SARS-CoV-2 infection - note the following publications:</p><ul><li>SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro. Liu F, Han K, Blair R, Kenst K, Qin Z, Upcin B, Wörsdörfer P, Midkiff CC, Mudd J, Belyaeva E, Milligan NS, Rorison TD, Wagner N, Bodem J, Dölken L, Aktas BH, Vander Heide RS, Yin XM, Kolls JK, Roy CJ, Rappaport J, Ergün S, Qin X. <a href="https://nam11.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34307198%2F&data=04%7C01%7CRhonda.Henshall-Powell%40bio-techne.com%7C320715799f1d482033ae08d95bc51b39%7C6792a6a4b78747009c17f7364d0714a2%7C0%7C0%7C637641724557204374%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=mHcV9KArhoq5TTQDFEn%2FN%2BC09293Bgh%2F1PbNVEKiVFk%3D&reserved=0">Front Cell Infect Microbiol. 2021 Jul 6;11:701278.</a> </li><li>Lung Expression of Human Angiotensin-Converting Enzyme 2 Sensitizes the Mouse to SARS-CoV-2 Infection. Han K, Blair RV, Iwanaga N, Liu F, Russell-Lodrigue KE, Qin Z, Midkiff CC, Golden NA, Doyle-Meyers LA, Kabir ME, Chandler KE, Cutrera KL, Ren M, Monjure CJ, Lehmicke G, Fischer T, Beddingfield B, Wanek AG, Birnbaum A, Maness NJ, Roy CJ, Datta PK, Rappaport J, Kolls JK, Qin X. <a href="https://nam11.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32991819%2F&data=04%7C01%7CRhonda.Henshall-Powell%40bio-techne.com%7C320715799f1d482033ae08d95bc51b39%7C6792a6a4b78747009c17f7364d0714a2%7C0%7C0%7C637641724557214369%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=T0HaZW3bwCHfLos7czc2DLCS%2Fu%2F5Wk2avmNjiKLFu%2Fs%3D&reserved=0">Am J Respir Cell Mol Biol. 2021 Jan;64(1):79-88.</a></li><li>Novel ACE2-IgG1 fusions with improved in vitro and in vivo activity against SARS-CoV2. Iwanaga N, Cooper L, Rong L, Beddingfield B, Crabtree J, Tripp RA, Qin X, Kolls JK. <a href="https://nam11.safelinks.protection.outlook.com/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F32587964%2F&data=04%7C01%7CRhonda.Henshall-Powell%40bio-techne.com%7C320715799f1d482033ae08d95bc51b39%7C6792a6a4b78747009c17f7364d0714a2%7C0%7C0%7C637641724557224363%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=zeyQwyg527%2F%2Fq1BHScW7%2Buu5vEaD4LAohoj6nG3lQ3c%3D&reserved=0">bioRxiv. 2020 Jul 24:2020.06.15.152157</a>.</li></ul></li><li><p>Arkana Labs utilized RNAscope to demonstrate that a COVID-19 positive patient with collapsing glomerulopathy did not show presence of the SARS-CoV-2 virus in the kidney biopsy. They relied on RNAscope for viral detection because of non-specific detection observed using IHC.<br /><a href="https://www.kireports.org/article/S2468-0249(20)31172-4/pdf" target="_blank">Larsen et al., Collapsing Glomerulopathy in a Patient With Coronavirus Disease 2019 (COVID-19) Kid Inter Rep, 2020, doi: 10.1016/j.ekir.2020.04.002</a></p></li><li><p>Researchers from Chinese Academy of Medical Sciences have developed a model to study the SARS-CoV-2 pathogenesis to aid in the advancement of viral vaccine and drug development. They observed differences in susceptibility to SARS-CoV-2 between the 3 NHP species with the M.mulatta species being more susceptible compared to M. fascicularis and C.jacchus. Using <strong>RNAscope Multiplex Fluorescent V2 Assay</strong>, the virus could be visualized and localized in different parts of the lung tissue with the RNAscope Probe- V-nCoV2019-S.<br /><a href="https://www.biorxiv.org/content/10.1101/2020.04.08.031807v1" target="_blank">https://www.biorxiv.org/content/10.1101/2020.04.08.031807v1</a></p></li><li><p>Researchers at U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) utilized <strong>RNAscope 2.5 HD Red Assay</strong> to detect SARS-CoV-2 in non-human primate FFPE cell pellets. Using SARS-CoV-2 positive and negative strand specific RNAscope probes, researchers were able simultaneously visualize the virus and viral replication by <strong>RNAscope Multiplex Fluorescent V2 assay</strong>.<br /><a href="https://www.biorxiv.org/content/10.1101/2020.04.21.042911v1" target="_blank">https://www.biorxiv.org/content/10.1101/2020.04.21.042911v1</a></p><br /><a href="https://www.facebook.com/384945464967710/photos/a.405834999545423/2658452000950367/?type=3&theater" target="_blank"><img alt="" src="/sites/default/files/USAMRIID.png" /></a><br /><strong>The information contained in this statement does not necessarily reflect the position or the policy of the Government and no official endorsement should be inferred</strong></li></ul></div><div class="classification application-table pub-table"><h2>Related Publications</h2><h3>Recent publications using the RNAscope assays for the detection of SARS-CoV and MERS-Cov viruses</h3><ol><li>Corbett, K. S.,  <em>et al., </em>(2020). <em>Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates.</em> New England Journal of Medicine.</li><li>Chandrashekar, A., <em>et al.,</em> (2020). <em>SARS-CoV-2 infection protects against rechallenge in rhesus macaques.</em> Science.</li><li>Shiers, S., Ray, P., Wangzhou, A., Tatsui, C. E., Rhines, L., Li, Y., ... & Price, T. J. (2020). <em>ACE2 expression in human dorsal root ganglion sensory neurons: implications for SARS-CoV-2 virus-induced neurological effects</em>. BioRxiv.</li><li>Nuovo, G. J., Magro, C., & Mikhail, A. (2020). <em>Cytologic and molecular correlates of SARS-CoV-2 infection of the nasopharynx. </em>Annals of Diagnostic Pathology, 151565.</li><li>Haagmans, B.L. <em>et al.</em>, <em>Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits.</em> J Virol, 2015. <strong>89</strong>(11): p. 6131-5.</li><li>Haagmans, B.L. <em>et al</em>., <em>An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels.</em> Science, 2016. <strong>351</strong>(6268): p. 77-81.</li><li>Cha, R.H.Y., <em>et al.,</em> <em>A Case Report of a Middle East Respiratory Syndrome Survivor with Kidney Biopsy Results.</em> J Korean Med Sci, 2016. <strong>31</strong>(4): p. 635-40.</li><li>Vergara-Alert, J.v.d.B., <em>et al.,</em> <em>Livestock Susceptibility to Infection with Middle East Respiratory Syndrome Coronavirus.</em> Emerg Infect Dis, 2017. <strong>23</strong>(2).</li></ol><p> </p><p> </p><p> </p></div></div></div></div></div></div></div></div> <script type="text/javascript"> jQuery(document).ready(function($) { var windowsize = $(window).width(); if(windowsize < 768){ slidestart = $('#myTab li.active').index(); $('#myTab').bxSlider({ moveSlides: 1, minSlides: 1, maxSlides: 6, slideWidth: 200, //infiniteLoop: false, pager: false, //hideControlOnEnd: true, startSlide: slidestart }); } var last; $('#video-popup-show').popup(); if ( $( "a.video-link" ).length ) { last = $('a.video-link').attr("href").split('/').pop(); $('.video-preview').attr("src","https://www.youtube.com/embed/"+last); } $('.video-link').click(function(event) { event.preventDefault(); $('#video-popup-show').popup('show'); }); $('.video-popup-show_close').click(function(event) { event.preventDefault(); $('.video-preview').attr('src', $('.video-preview').attr('src')); }); $('.search-app-submit').click(function(event) { event.preventDefault(); last_url = $('.search-app-url').val(); key_word = $('.search-app-text').val(); if(last_url == ""){ window.location.href = '/search/site/'+key_word+'/cms/probes'; }else{ window.location.href = '/search/site/'+key_word+'/cms/probes'+last_url; } }); $('.search-app-text').keypress(function(event) { var keycode = (event.keyCode ? event.keyCode : event.which); if(keycode == '13'){ $('.search-app-submit').trigger('click'); } }); $('.download-pdf-app .down-pdf-btn').click(function(event) { event.preventDefault(); $(this).parent().parent().find('.iframe-content').slideToggle(); var pardot = $(this).parent().parent().find('.iframe-content'); setTimeout(function(){ $('html, body').animate({ scrollTop: pardot.offset().top - 120 }, 500); }, 500) }); $('.download-pdf-app .down-pdf-btn.glitch-pdf-btn').click(function(event) { event.preventDefault(); $(this).parent().parent().parent().find('.iframe-content').slideToggle(); var pardot = $(this).parent().parent().parent().find('.iframe-content'); setTimeout(function(){ $('html, body').animate({ scrollTop: pardot.offset().top - 120 }, 500); }, 500) }); $('.learn-more-pardot').click(function() { var left = ($(window).width()/2)-(800/2), top = ($(window).height()/2)-(800/2), NWin = window.open($(this).prop('href'), '', 'height=800, width=800, top='+top+', left='+left); if (window.focus) { NWin.focus(); } return false; }); $('.app-note .download-pdf-app .learn-more-pardot').click(function(event) { event.preventDefault(); $('.app-note .iframe-content').slideToggle(); }); //$( "#application-accordion" ).accordion(); $(".scientist-popup").magnificPopup({ type:'inline', showCloseBtn:false, }); $('.animal-model-species').click(function(event) { event.preventDefault(); window.location = "/search/site/"+$(this).html()+"/cms/probes"; }); $('.models-to-search').click(function(event) { event.preventDefault(); window.location = "/search/site/"+$(this).children('.model-name').children('.model-search-name').html()+"/cms/probes"; }); $('.animal-model-dual-species').click(function(event) { event.preventDefault(); window.location = "/search/site/"+$(this).find('span').html()+"/cms/probes"; }); $(document).on('click', '.r-readless-1', function(event) { $(this).parent().find('.r-hide').slideToggle(); $(this).text( $(this).text() == 'Read More' ? 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"https://acdbio.com/search/site/"+$(this).html()+"/cms/probes"; }); $('.read-more-table').readmore({ speed: 500, moreLink: '<a href="#" class="readmore">Read More <span>+</span></a>', lessLink: '<a href="#" class="readless">Read Less <span>-</span></a>' }); }); </script> <style type='text/css'> .embeddedServiceHelpButton .helpButton .uiButton { background-color: #005f9e; font-family: "Arial", sans-serif; max-width: none; } .embeddedServiceHelpButton .embeddedServiceIcon::before { font-size: 2.25em; } .embeddedServiceHelpButton .helpButton .uiButton:hover { background-color: #0097ed; } .embeddedServiceHelpButton .helpButton .uiButton:focus { outline: 1px solid #005290; text-decoration: none; } .embeddedServiceHelpButton .helpButton .uiButton:active { text-decoration: none; } .embeddedServiceHelpButton .helpButton .helpButtonEnabled:hover::before, .embeddedServiceHelpButton .helpButton .helpButtonEnabled:focus::before { background-color: #0097ed; text-decoration: none; } .message { 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