Day 1 Agenda | 2nd Cell Therapy for Autoimmune Disease Summit

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</div> </div> </div> <div class="fl-col-group fl-node-9r14sx26byzk" data-node="9r14sx26byzk"> <div class="fl-col fl-node-zy7bksf85c1l fl-col-bg-color" data-node="zy7bksf85c1l"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-lkha7246cgw9" data-node="lkha7246cgw9"> <div class="fl-module-content fl-node-content"> <h1 class="fl-heading"> <span class="fl-heading-text">December 2-4, 2024 <BR> Philadelphia, PA</span> </h1> </div> </div> </div> </div> </div> </div> </div> </div> </header> <div id="fl-main-content" class="fl-page-content" itemprop="mainContentOfPage" role="main"> <div class="fl-content-full container"> <div class="row"> <div class="fl-content col-md-12"> <article class="fl-post post-595 page type-page status-publish has-post-thumbnail hentry" id="fl-post-595" itemscope="itemscope" itemtype="https://schema.org/CreativeWork"> <div class="fl-post-content clearfix" itemprop="text"> <div class="fl-builder-content fl-builder-content-595 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="595"><div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-92vdtgfp6oym fl-row-default-height fl-row-align-center" data-node="92vdtgfp6oym"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-dw1vbrmepnjh" data-node="dw1vbrmepnjh"> <div class="fl-col fl-node-kr67i2ygoe1x fl-col-bg-photo fl-col-bg-overlay" data-node="kr67i2ygoe1x"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-n8k09vlio7wd" data-node="n8k09vlio7wd"> <div class="fl-module-content fl-node-content"> <h1 class="fl-heading"> <span class="fl-heading-text">Conference Day One</span> </h1> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-usz4x1l8n5br" data-node="usz4x1l8n5br"> <div class="fl-col fl-node-6hwzj24pe30o fl-col-bg-color fl-col-has-cols" data-node="6hwzj24pe30o"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-f0cziuqonl1e" data-node="f0cziuqonl1e"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: #c4aeba"> <h3> <span class="time"> 7:00 am </span> Check-in & Coffee </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:15 am </span> Chair’s Opening Remarks </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20683" class="view-speaker" speaker-id="20683"><span>Fred Aslan</span></a></em> Chief Executive Officer, Artiva Biotherapeutics, Inc </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <span style="color:#AE5CA7;font-size:22px;"><b><center>Diving into Challenges & Successes in the Autoimmune Space to Direct Future Outcomes</b></center></span> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:30 am </span> Industry Leader’s Fireside Chat: Exploring Present Advancements & Challenges in the Cell Therapies for Autoimmune Disease Space </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20114" class="view-speaker" speaker-id="20114"><span>Marlene Carrasco</span></a></em> Global Clinical Head Immunology Cell Therapy, AstraZeneca </li> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20107" class="view-speaker" speaker-id="20107"><span>Susanne Diehl</span></a></em> Global Program Head Immunology, Novartis </li> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20110" class="view-speaker" speaker-id="20110"><span>Samik Basu</span></a></em> Chief Scientific Officer, Cabaletta Bio </li> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20683" class="view-speaker" speaker-id="20683"><span>Fred Aslan</span></a></em> Chief Executive Officer, Artiva Biotherapeutics, Inc </li> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker22624" class="view-speaker" speaker-id="22624"><span>Renee Randazzo</span></a></em> Early Development Program, Research & Early Development Leader, Bristol Myers Squibb </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>An interactive panel discussion from the industry leaders to set the scene on the autoimmune space. Ask your questions live to understand the expert’s thoughts on key topics including:</p> <p></p> <p>• How has this rapidly evolving space advanced this year?</p> <p>• Discussing the latest findings and what this means for the cell therapy for autoimmune field</p> <p>• What are some new challenges that have come up that we previously haven’t faced?</p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:30 am </span> Case Study: Perspectives on Bringing Cell Therapies to the Autoimmune Space: From Concept to Clinic </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker22626" class="view-speaker" speaker-id="22626"><span>Milos Miljkovic</span></a></em> Chief Medical Officer, Cartesian Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li><span style="font-size: 14px;">Unique considerations for patients with autoimmune disease relative to the historical oncology setting of cell therapy</span></li> <li><span style="font-size: 14px;">Sharing the journey of bringing cell therapy to the autoimmune field from concept through phase 2 trials</span></li> <li><span style="font-size: 14px;">Perspective on opportunities and key open questions to drive impact in this space</span></li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 10:00 am </span> <span style="color:#3DC5CB;">Morning Break & Speed Networking </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>As the autoimmune community is reunited, this valuable session will ensure you can reconnect with your peers in the room to make new and lasting connections. Also, don’t forget to enjoy some refreshments before we split off into the two different tracks: <strong style="color: rgb(62, 212, 180);">Preclinical Development, & Clinical Strategy</strong></p> </div>  </div> </div> </div> </div> <div class="fl-col-group fl-node-r2qo7njavhwf fl-col-group-nested" data-node="r2qo7njavhwf"> <div class="fl-col fl-node-axmr1fv5wztn fl-col-bg-color fl-col-small" data-node="axmr1fv5wztn"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-u2is519j8oab" data-node="u2is519j8oab"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: #ae5ca7"> <h3> <span class="time"> </span> <span style="color:#FFFFFF;font-size:20px;"><center>Preclinical Development <br> Track Chair – Marko Radic, Professor, University of Tennessee </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #ae5ca7"> <h3> <span class="time"> </span> <span style="color:#FFFFFF;font-size:20px;"><center>Selecting Effective Preclinical Models for Accurate Recapitulation of Disease </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 11:00 am </span> A New & Advanced Fully Humanized Mouse Model that Mounts Mature & Neutralizing Antibody Responses & Develop Lupus </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20163" class="view-speaker" speaker-id="20163"><span>Paolo Casali</span></a></em> Professor & Distinguished Microbiology, Immunology & Molecular Genetics, UT Health San Antonio </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Developing a new and advanced fully humanized THX Lupus mice with a full human immune system</p> <p>• Discussing the use of estradiol to condition and promote the maturation of immune cells</p> <p>• Discussing estradiol activity in differentiating immune cell elements and potentiating the immune response</p> <p></p> <p><strong style="font-size: 16px; color: rgb(174, 92, 167);">NEW DATA</strong></p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 11:30 am </span> Roundtable Discussion: Key Considerations When Selecting the Most Appropriate Preclinical Models </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20163" class="view-speaker" speaker-id="20163"><span>Paolo Casali</span></a></em> Professor & Distinguished Microbiology, Immunology & Molecular Genetics, UT Health San Antonio </li> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20170" class="view-speaker" speaker-id="20170"><span>Marko Radic</span></a></em> Professor, The University of Tennessee Health Science Center </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Evaluating different models such as acute inflammatory, experimental autoimmune encephalomyelitis (EAE), nod scid gamma mice and more</p> <p>• What are the priorities in animal model requirements for different cell therapy types?</p> <p>• What do the most appropriate animal models look like among different indications?</p> </div>  </div> </div> </div> </div> </div> </div> <div class="fl-col fl-node-ja6r8dc72l53 fl-col-bg-color fl-col-small" data-node="ja6r8dc72l53"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-zfr7sokqnwe5" data-node="zfr7sokqnwe5"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: #3dc5cb"> <h3> <span class="time"> </span> <span style="color:#FFFFFF;font-size:20px;"><center>Clinical Strategy <br> Track Chair – Greg Deener, Chief Executive Officer, iCell Gene Therapeutics </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #3dc5cb"> <h3> <span class="time"> </span> <span style="color:#FFFFFF;font-size:20px;"><center>Advancing Understanding of Cell Therapies & Autoimmune Disease to Accelerate Development </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 11:00 am </span> How Our Knowledge of Neuroinflammatory Pathophysiology Informs Understanding Potential Benefits of Cell Therapies </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20209" class="view-speaker" speaker-id="20209"><span>Richard Ransohoff</span></a></em> Venture Partner, Third Rock Ventures LLC </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Discussing mechanistic insights into neuroinflammatory diseases such as multiple sclerosis</p> <p>• Evaluating which neuroinflammatory patients are most amenable to which cell therapies based on disease understanding</p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 11:30 am </span> Panel Discussion: Uniting Industry & Academia to Accelerate Cell Therapy Development for Autoimmune Disease <br> <br> Moderator – Greg Deener, Chief Executive Officer, iCell Gene Therapeutics </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20217" class="view-speaker" speaker-id="20217"><span>Stephen Waggoner</span></a></em> Professor, Cincinatti Children’s Medical Center </li> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20565" class="view-speaker" speaker-id="20565"><span>Tom Wickham</span></a></em> Chief Scientific Officer, GentiBio </li> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20191" class="view-speaker" speaker-id="20191"><span>Tony Arulanandam</span></a></em> CEO and Founder, Synaptimmune Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• How can we foster increased partnerships between industry and academic/clinical institutions to strengthen our understanding of current autoimmune indications?</p> <p>• How do we build on the established experiences where academic clinical trials provided early POC for cell therapy in AID to attract investment and clinical development and commercialization of cell therapies in the autoimmune space?</p> </div>  </div> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-dnpuyc9fv4jk fl-col-group-nested" data-node="dnpuyc9fv4jk"> <div class="fl-col fl-node-lrxq89dvzy6h fl-col-bg-color" data-node="lrxq89dvzy6h"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-frpthbyl4om8" data-node="frpthbyl4om8"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <span style="color:#3DC5CB;font-size:20px;"><center>12.00 Lunch Break & Networking </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-0ephqdu4gizy fl-col-group-nested" data-node="0ephqdu4gizy"> <div class="fl-col fl-node-ulbm9ekhapsv fl-col-bg-color fl-col-small" data-node="ulbm9ekhapsv"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-szn42ld8ucwx" data-node="szn42ld8ucwx"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: #ae5ca7"> <h3> <span class="time"> </span> <span style="color:#FFFFFF;font-size:20px;"><center>Novel Approaches to Engineering Cell Therapies for Increased Efficacy in Autoimmune Indications </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 1:00 pm </span> Engineered Tregs to Designed to Overcome Therapeutic Bottlenecks for Achieving Therapeutic Benefit in Type 1 Diabetes </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20565" class="view-speaker" speaker-id="20565"><span>Tom Wickham</span></a></em> Chief Scientific Officer, GentiBio </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Discussing the advantages of GNT-122, including a targeted, stable phenotype with a chemically inducible signaling complex (CISC) to overcome the IL-2 scarce environment in T1D</p> <p>• Highlighting the importance of Tregs in regulating acute inflammatory responses</p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 1:30 pm </span> Engineered Stem Cell Derived NKT & Gamma Delta T-cell Therapies: Scalable Products with Enhanced Safety for Autoimmune Diseases </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20187" class="view-speaker" speaker-id="20187"><span>Jason Damiano</span></a></em> Chief Scientific Officer, Appia Bio </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Highlighting strong efficacy and depth of B-cell depletion, comparable to CAR-T cells in preclinical models</p> <p>• Discussing modifications of NKT and gamma delta T-cells for reduced risk of adverse events such as CRS and ICANS</p> <p>• Elucidating key market advantages of NKT cells, such as scalable manufacturing and off-the-shelf availability</p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 2:00 pm </span> Next Generation of Dual Antigen IDR-CAR-T cells for Autoimmune Diseases </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20191" class="view-speaker" speaker-id="20191"><span>Tony Arulanandam</span></a></em> CEO and Founder, Synaptimmune Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Discussing increased potency, sensitivity and complete immune reset of dual antigen targeting IDR-CAR-T cells</p> <p>• Proof of concept data for SLE and other autoantibodymediated autoimmune indications targeting B and T-cells</p> <p>• Development of best-in-class next generation of immune cell depleting CAR-T cells and tissue or organ system modulating CAR-Tregs</p> <p></p> <p><strong style="font-size: 16px; color: rgb(174, 92, 167);">NEW DATA</strong></p> </div>  </div> </div> </div> </div> </div> </div> <div class="fl-col fl-node-y3w4dezaxf81 fl-col-bg-color fl-col-small" data-node="y3w4dezaxf81"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-pufrxiq6wvn1" data-node="pufrxiq6wvn1"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 1:00 pm </span> Uncovering Translational Biomarkers for Disease Monitoring & Mechanistic Insights of Drugs </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20226" class="view-speaker" speaker-id="20226"><span>Matthew Collinson-Pautz</span></a></em> Director - Preclinical & Translational Research, Indapta Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Key translational biomarkers for indications such as LN and MS for enhanced disease monitoring and therapeutic activity</p> <p>• Leveraging translational biomarkers to provide early insights in clinical trials</p> <p>• How does the application of cell therapies alter the biomarker approach in these diseases? And where do they overlap to provide historical benchmarking?</p> </div>  </div> <div class="inner-agenda" style="background: #3dc5cb"> <h3> <span class="time"> </span> <span style="color:#FFFFFF;font-size:20px;"><center>Discovering Novel Antigens to Expand Beyond CD19 & into Unmet Indications </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 1:30 pm </span> Looking Beyond CD19 Antigens for Selective Depletion </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20232" class="view-speaker" speaker-id="20232"><span>Yongke zhang</span></a></em> CSO, IASO BioTherapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Exploring antigens such as BCMA, BAFF, CD20, and CD90 to improve the targeting of B-cells</p> <p>• Can we combine targeting of different antigens for more therapy efficacy?</p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 2:00 pm </span> CD19/CD3 Bispecific T-cell Engagers as an Alternative for Safer B-Cell Depletion </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20236" class="view-speaker" speaker-id="20236"><span>Jeffrey Jones</span></a></em> Chief Medical Officer, CULLINAN THERAPEUTICS, INC. </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Discussing clinical results of starting dose efficacy in B-cell lymphoma demonstrating B-cell depletion</p> <p>• Highlighting the application of T-cell engagers to SLE and other autoimmune indications</p> </div>  </div> </div> </div> </div> </div> </div> </div> <div class="fl-module fl-module-ee-agenda fl-node-7jevopit02kc" data-node="7jevopit02kc"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <span style="color:#3DC5CB;font-size:20px;"><center> 2:30 Afternoon Break & Poster Session </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> </div> </div> </div> <div class="fl-module fl-module-ee-agenda fl-node-xo54d37n2siw" data-node="xo54d37n2siw"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <span style="color:#AE5CA7;font-size:20px;"><center>Understanding Long Term Responses & Relapses by Uncovering Cell Therapy Biology in Autoimmune Disease </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 3:30 pm </span> Insights into Mechanisms & Prolonged Effects of Cell Therapies in Systemic Lupus Erythematosus </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20244" class="view-speaker" speaker-id="20244"><span>Laurence morel</span></a></em> Professor, UT Health San Antonio </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Diving into our current knowledge of cell therapy mechanisms in autoimmune disease to understand the long-term effects</p> <p>• Is lasting efficacy desirable when treating autoimmune disease?</p> <p>• Manipulating metabolism of Tregs to understand their effect in humanized mouse models of Lupus</p> <p></p> <p><strong style="font-size: 16px; color: rgb(174, 92, 167);">NEW DATA</strong></p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:00 pm </span> Understanding Efficacy & Longevity of CAR-Ts in Autoimmune Disease </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://cell-therapy-autoimmune-disease.com/speakers/#speaker20170" class="view-speaker" speaker-id="20170"><span>Marko Radic</span></a></em> Professor, The University of Tennessee Health Science Center </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Discussing the process of trogocytosis in CAR-Ts and its effects on T-cell exhaustion</p> <p>• Using mouse models of lupus for increased understanding of CAR-T mechanisms</p> <p></p> <p><strong style="color: rgb(174, 92, 167); font-size: 16px; background-color: rgb(255, 255, 255);">NEW DATA</strong></p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:30 pm </span> Closing Remarks </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: #c4aeba"> <h3> <span class="time"> 4:40 pm </span> Close of Conference Day One </h3>   <div 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$(this.wrapperClass).find('.fl-has-submenu').removeClass('focus');$(this.wrapperClass).find('.fl-has-submenu .sub-menu').removeClass('focus');},this));$(this.wrapperClass+' ul.menu > li:last-child').on('focusout',$.proxy(function(e){if($(this.wrapperClass).find('.fl-menu-mobile-toggle').hasClass('fl-active')&&('expanded'!==this.mobileToggle)){if(!$(e.relatedTarget).parent().hasClass('menu-item')){$(this.wrapperClass).find('.fl-menu-mobile-toggle').trigger('click');}}},this));};FLBuilderMenu.prototype={nodeClass:'',wrapperClass:'',type:'',breakPoints:{},$submenus:null,_isMobile:function(){return this.currentBrowserWidth<=this.breakPoints.small?true:false;},_isMedium:function(){return this.currentBrowserWidth<=this.breakPoints.medium?true:false;},_isLarge:function(){return this.currentBrowserWidth<=this.breakPoints.large?true:false;},_isMenuToggle:function(){if(('always'==this.mobileBreakpoint||(this._isMobile()&&'mobile'==this.mobileBreakpoint)||(this._isMedium()&&'medium-mobile'==this.mobileBreakpoint)||(this._isLarge()&&'large-mobile'==this.mobileBreakpoint))&&($(this.wrapperClass).find('.fl-menu-mobile-toggle').is(':visible')||'expanded'==this.mobileToggle)){return true;} return false;},_initMenu:function(){this._setupSubmenu();this._menuOnFocus();this._menuOnEscape();this._submenuOnClick();if($(this.nodeClass).length&&this.type=='horizontal'){this._initMegaMenus();} if(this._isMenuToggle()||this.type=='accordion'){$(this.wrapperClass).off('mouseenter mouseleave');this._menuOnClick();this._clickOrHover();}else{$(this.wrapperClass).off('click');this._submenuOnRight();this._submenuRowZindexFix();} if(this.mobileToggle!='expanded'){this._toggleForMobile();} if($(this.wrapperClass).find('.fl-menu-search-item').length){this._toggleMenuSearch();} if($(this.wrapperClass).find('.fl-menu-cart-item').length){this._wooUpdateParams();}},_setupSubmenu:function(){$(this.wrapperClass+' ul.sub-menu').each(function(){$(this).closest('li').attr('aria-haspopup','true');});},_menuOnFocus:function(){var cKey=0,isShifted=false;$(this.nodeClass).off('keydown').on('keydown','a',function(e){cKey=e.which;isShifted=e.shiftKey;});$(this.nodeClass).off('focus').on('focus','a',$.proxy(function(e){var $menuItem=$(e.target).parents('.menu-item').first(),$parents=$(e.target).parentsUntil(this.wrapperClass);$('.fl-menu .focus').removeClass('focus');$parents.addClass('focus') if(!$menuItem.closest('.fl-has-submenu').hasClass('escaped')){$menuItem.addClass('focus')} else{$menuItem.closest('.fl-has-submenu').removeClass('focus escaped')}},this)).on('focusout','a',$.proxy(function(e){var el=$(e.target).parent(),$megaMenu=el.closest('.mega-menu'),$megaLastItem=$megaMenu.find('> .sub-menu > .menu-item:last-child'),$lastItem=el.parents('.fl-has-submenu:last').find('.menu-item:last'),isLastChild=!$megaMenu.length&&el.is($lastItem);if($megaMenu.length){isLastChild=el.is($megaLastItem)||el.is($megaLastItem.find('.menu-item:last-child'));} if(isLastChild&&cKey===9&&isShifted){isLastChild=false;cKey=0;isShifted=false;} else if(cKey===27){isLastChild=false;} if(isLastChild){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_menuOnEscape:function(){$('body').off('keydown').on('keydown',$.proxy(function(e){if(e.which!==27){return;} if($(e.target).closest('.menu-item').length){var activeSubmenu=null,menuItem=$(e.target).closest('.menu-item'),type=menuItem.closest('.fl-menu-accordion').length?'accordion':'horizontal';if('horizontal'===type){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('focus')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.parent().addClass('escaped');activeSubmenu.parent().find('a:first').focus();} else{if(menuItem.hasClass('fl-has-submenu')&&'accordion'===type&&menuItem.hasClass('fl-active')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.slideUp(400,function(){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('fl-active')){activeSubmenu.parent().last().find('a:first').focus();} else{menuItem.removeClass('focus');menuItem.parents('.menu-item').first().find('a:first').focus();} activeSubmenu.parent().last().removeClass('fl-active');});}} else{$('.fl-menu').find('li.menu-item.focus').last().removeClass('focus');}},this));},_menuOnClick:function(){$(this.wrapperClass).off().on('click','.fl-has-submenu-container',$.proxy(function(e){var $link=$(e.target).parents('.fl-has-submenu').first(),$subMenu=$link.children('.sub-menu').first(),$href=$link.children('.fl-has-submenu-container').first().find('> a').attr('href'),$subMenuParents=$(e.target).parents('.sub-menu'),$activeParents=$(e.target).parents('.fl-has-submenu.fl-active');if(!$subMenu.is(':visible')||$(e.target).hasClass('fl-menu-toggle')||($subMenu.is(':visible')&&(typeof $href==='undefined'||$href=='#'))){e.preventDefault();} else{e.stopPropagation();window.location.href=$href;return;} if($(this.wrapperClass).hasClass('fl-menu-accordion-collapse')){if(!$link.parents('.menu-item').hasClass('fl-active')){$('.menu .fl-active',this.wrapperClass).not($link).removeClass('fl-active');} else if($link.parents('.menu-item').hasClass('fl-active')&&$link.parent('.sub-menu').length){$('.menu .fl-active',this.wrapperClass).not($link).not($activeParents).removeClass('fl-active');} $('.sub-menu',this.wrapperClass).not($subMenu).not($subMenuParents).slideUp('normal');} if(!this.mobileStacked&&'horizontal'==this.type&&'expanded'==this.mobileToggle){$(this.wrapperClass).find('.fl-active').not($link).not($activeParents).removeClass('fl-active');} else{$subMenu.slideToggle();} $link.toggleClass('fl-active');e.stopPropagation();},this));},_submenuOnClick:function(){$(this.wrapperClass+' .sub-menu').off().on('click','a',$.proxy(function(e){if($(e.target).parent().hasClass('focus')){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_clickOrHover:function(){this.$submenus=this.$submenus||$(this.wrapperClass).find('.sub-menu');var $wrapper=$(this.wrapperClass),$menu=$wrapper.find('.menu');$li=$wrapper.find('.fl-has-submenu');if(this._isMenuToggle()){$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').fadeOut();}});}else{$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').css({'display':'','opacity':''});}});}},_submenuOnRight:function(){$(this.wrapperClass).on('mouseenter focus','.fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} var $link=$(e.currentTarget),$parent=$link.parent(),$subMenu=$link.find('.sub-menu'),subMenuWidth=$subMenu.width(),subMenuPos=0,bodyWidth=$('body').width();if($link.closest('.fl-menu-submenu-right').length!==0){$link.addClass('fl-menu-submenu-right');}else if($('body').hasClass('rtl')){subMenuPos=$parent.is('.sub-menu')?$parent.offset().left-subMenuWidth:$link.offset().left-$link.width()-subMenuWidth;if(subMenuPos<=0){$link.addClass('fl-menu-submenu-right');}}else{subMenuPos=$parent.is('.sub-menu')?$parent.offset().left+$parent.width()+subMenuWidth:$link.offset().left+$link.width()+subMenuWidth;if(subMenuPos>bodyWidth){$link.addClass('fl-menu-submenu-right');}}},this)).on('mouseleave','.fl-has-submenu',$.proxy(function(e){$(e.currentTarget).removeClass('fl-menu-submenu-right');},this));},_submenuRowZindexFix:function(e){$(this.wrapperClass).on('mouseenter','ul.menu > .fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} $(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','10');},this)).on('mouseleave','ul.menu > .fl-has-submenu',$.proxy(function(e){$(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','');},this));},_toggleForMobile:function(){var $wrapper=null,$menu=null,self=this;if(this._isMenuToggle()){if(this._isMobileBelowRowEnabled()){this._placeMobileMenuBelowRow();$wrapper=$(this.wrapperClass);$menu=$(this.nodeClass+'-clone');$menu.find('ul.menu').show();} else{$wrapper=$(this.wrapperClass);$menu=$wrapper.find('.menu');} if(!$wrapper.find('.fl-menu-mobile-toggle').hasClass('fl-active')&&!self.mobileFlyout){$menu.css({display:'none'});} if(self.mobileFlyout){this._initFlyoutMenu();} $wrapper.on('click','.fl-menu-mobile-toggle',function(e){$(this).toggleClass('fl-active');if(self.mobileFlyout){self._toggleFlyoutMenu();} else{var targetMenu=null;if(self.mobileBelowRow){targetMenu=$(this).closest('.fl-col').next('.fl-menu-mobile-clone');}else{targetMenu=$(this).closest('.fl-menu').find('ul.menu');} if(targetMenu.length){$menu=$(targetMenu);} $menu.slideToggle();} e.stopPropagation();});$menu.off().on('click','.menu-item > a[href*="#"]:not([href="#"])',function(e){var $href=$(this).attr('href'),$targetID=$href.split('#')[1],element=$('#'+$targetID);if($('body').find(element).length>0){$(this).toggleClass('fl-active');FLBuilderLayout._scrollToElement(element);if(!self._isMenuToggle()){$menu.slideToggle();}}});} else{if(this._isMobileBelowRowEnabled()){this._removeMenuFromBelowRow();} $wrapper=$(this.wrapperClass),$menu=$wrapper.find('ul.menu');$wrapper.find('.fl-menu-mobile-toggle').removeClass('fl-active');$menu.css({display:''});if(!this._isMobileBelowRowEnabled()){$menu.off('click','.menu-item > a[href*="#"]:not([href="#"])');} if(this.mobileFlyout&&$wrapper.find('.fl-menu-mobile-flyout').length>0){$('body').css('margin','');$('.fl-builder-ui-pinned-content-transform').css('transform','');$menu.unwrap();$wrapper.find('.fl-menu-mobile-close').remove();$wrapper.find('.fl-menu-mobile-opacity').remove();}}},_initMegaMenus:function(){var module=$(this.nodeClass),rowContent=module.closest('.fl-row-content'),rowWidth=rowContent.width(),megas=module.find('.mega-menu'),disabled=module.find('.mega-menu-disabled'),isToggle=this._isMenuToggle();if(isToggle){megas.removeClass('mega-menu').addClass('mega-menu-disabled');module.find('li.mega-menu-disabled > ul.sub-menu').css('width','');rowContent.css('position','');}else{disabled.removeClass('mega-menu-disabled').addClass('mega-menu');module.find('li.mega-menu > ul.sub-menu').css('width',rowWidth+'px');rowContent.css('position','relative');}},_isMobileBelowRowEnabled:function(){return this.mobileBelowRow&&$(this.nodeClass).closest('.fl-col').length;},_placeMobileMenuBelowRow:function(){if($(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=null,col=module.closest('.fl-col');if(module.length<1){return;} clone=(module.length>1)?$(module[0]).clone():module.clone();module.find('ul.menu').remove();clone.addClass((this.nodeClass+'-clone').replace('.',''));clone.addClass('fl-menu-mobile-clone');clone.find('.fl-menu-mobile-toggle').remove();col.after(clone);if(module.hasClass('fl-animation')){clone.removeClass('fl-animation');} this._menuOnClick();},_removeMenuFromBelowRow:function(){if(!$(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=$(this.nodeClass+'-clone'),menu=clone.find('ul.menu');module.find('.fl-menu-mobile-toggle').after(menu);clone.remove();menu.find('a').each(FLBuilderLayout._initAnchorLink);},_initFlyoutMenu:function(){var win=$(window),wrapper=$(this.wrapperClass),menu=wrapper.find('ul.menu'),button=wrapper.find('.fl-menu-mobile-toggle');if(0===wrapper.find('.fl-menu-mobile-flyout').length){menu.wrap('<div class="fl-menu-mobile-flyout"></div>');} if(0===wrapper.find('.fl-menu-mobile-close').length){close=window.fl_responsive_close||'Close' wrapper.find('.fl-menu-mobile-flyout').prepend('<button class="fl-menu-mobile-close" aria-label="'+close+'"><i class="fas fa-times" aria-hidden="true"></i></button>');} if(wrapper.hasClass('fl-menu-responsive-flyout-push-opacity')&&0===wrapper.find('.fl-menu-mobile-opacity').length){wrapper.append('<div class="fl-menu-mobile-opacity"></div>');} wrapper.on('click','.fl-menu-mobile-opacity, .fl-menu-mobile-close',function(e){button.trigger('click');e.stopPropagation();});if('undefined'!==typeof FLBuilder){FLBuilder.addHook('restartEditingSession',function(){$('.fl-builder-ui-pinned-content-transform').css('transform','');if(button.hasClass('fl-active')){button.trigger('click');}});}},_toggleFlyoutMenu:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),position=wrapper.hasClass('fl-flyout-right')?'right':'left',pushMenu=wrapper.hasClass('fl-menu-responsive-flyout-push')||wrapper.hasClass('fl-menu-responsive-flyout-push-opacity'),opacity=wrapper.find('.fl-menu-mobile-opacity'),marginPos={},posAttr={},fixedPos={},winHeight=$(window).height(),fixedHeader=$('header, header > div');this._resizeFlyoutMenuPanel();if($('.fl-builder-ui-pinned-content-transform').length>0&&!$('body').hasClass('fl-builder-edit')){$('.fl-builder-ui-pinned-content-transform').css('transform','none');} if(pushMenu){marginPos['margin-'+position]=button.hasClass('fl-active')?'250px':'0px';$('body').animate(marginPos,200);if(fixedHeader.length>0){fixedPos[position]=button.hasClass('fl-active')?'250px':'0px';fixedHeader.each(function(){if('fixed'==$(this).css('position')){$(this).css({'-webkit-transition':'none','-o-transition':'none','transition':'none'});$(this).animate(fixedPos,200);}});}} if(opacity.length>0&&button.hasClass('fl-active')){opacity.show();} else{opacity.hide();}},_resizeFlyoutMenuPanel:function(){const wrapper=$(this.wrapperClass);const wrapFlyout=wrapper.find('.fl-menu-mobile-flyout');if(wrapFlyout.length>0){wrapFlyout.css(this._getFlyoutMenuPanelPosition());}},_getFlyoutMenuPanelPosition:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),side=wrapper.hasClass('fl-flyout-right')?'right':'left',winHeight=$(window).outerHeight(),winTop=$(window).scrollTop(),adminBarHeight=$('#wpadminbar').length?$('#wpadminbar').height():0,flyoutPosition={};flyoutPosition[side]='-267px';if(!button.hasClass('fl-active')){return flyoutPosition;} flyoutPosition[side]='0px';flyoutPosition['height']=winHeight+'px';flyoutPosition['top']='0px';if(adminBarHeight>0){const diff=adminBarHeight-winTop;flyoutPosition['top']=diff<=0?'0px':(diff)+'px';} return flyoutPosition;},_toggleMenuSearch:function(){var wrapper=$(this.wrapperClass).find('.fl-menu-search-item'),button=wrapper.find('a.fl-button'),form=wrapper.find('.fl-search-form-input-wrap'),self=this;button.on('click',function(e){e.preventDefault();if(form.is(':visible')){form.stop().fadeOut(200);} else{form.stop().fadeIn(200);$('body').on('click.fl-menu-search',$.proxy(self._hideMenuSearch,self));form.find('.fl-search-text').focus();}});},_hideMenuSearch:function(e){var form=$(this.wrapperClass).find('.fl-search-form-input-wrap');if(e!==undefined){if($(e.target).closest('.fl-menu-search-item').length>0){return;}} form.stop().fadeOut(200);$('body').off('click.fl-menu-search');},_wooUpdateParams:function(){if('undefined'!==typeof wc_cart_fragments_params){wc_cart_fragments_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;} if('undefined'!==typeof wc_add_to_cart_params){wc_add_to_cart_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;}},};})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5cb735f42d5d2',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'54',mobileStacked:true,});});})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5cf92200ec99d',type:'accordion',mobile:'hamburger',mobileBelowRow:false,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'always',postId:'54',mobileStacked:true,});});})(jQuery);;jQuery(function($){$(function(){$('.fl-node-5gx1lc04miqy .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;jQuery(function($){$(function(){$('.fl-node-98lu5x1faibh .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;;var FLBuilderCountdown;var FLBuilderCountdownIntervals=FLBuilderCountdownIntervals||[];(function($){FLBuilderCountdown=function(settings){this.nodeID=settings.id;this.nodeClass='.fl-node-'+settings.id;this.wrapperClass=this.nodeClass+' .fl-countdown';this.dateWrapper=this.nodeClass+' .fl-countdown-days';this.dateLabel=$(this.dateWrapper+' .fl-countdown-unit-label').data('label');this.hoursWrapper=this.nodeClass+' .fl-countdown-hours';this.hoursLabel=$(this.hoursWrapper+' .fl-countdown-unit-label').data('label');this.minutesWrapper=this.nodeClass+' .fl-countdown-minutes';this.minutesLabel=$(this.minutesWrapper+' .fl-countdown-unit-label').data('label');this.secondsWrapper=this.nodeClass+' .fl-countdown-seconds';this.secondsLabel=$(this.secondsWrapper+' .fl-countdown-unit-label').data('label');this.timestamp=settings.time;this.type=settings.type;this.redirect=settings.redirect;this.redirect_url=settings.redirect_url;this._initCountdown();};FLBuilderCountdown.prototype={nodeClass:'',wrapperClass:'',countdown:'',dateWrapper:'',dateLabel:'',hoursWrapper:'',hoursLabel:'',minutesWrapper:'',minutesLabel:'',secondsWrapper:'',secondsLabel:'',timestamp:'',_getTimeRemaining:function(endtime){var t=Date.parse(endtime)-Date.parse(new Date());var seconds=Math.floor((t/1000)%60);var minutes=Math.floor((t/1000/60)%60);var hours=Math.floor((t/(1000*60*60))%24);var days=Math.floor(t/(1000*60*60*24));return{'total':t,'days':(days<10)?('0'+days):days,'hours':('0'+hours).slice(-2),'minutes':('0'+minutes).slice(-2),'seconds':('0'+seconds).slice(-2)};},_setTimeRemaining:function(shouldRedirect){var t=this._getTimeRemaining(this.timestamp),wrappers={days:$(this.dateWrapper),hours:$(this.hoursWrapper),minutes:$(this.minutesWrapper),seconds:$(this.secondsWrapper),},labels={days:this.dateLabel,hours:this.hoursLabel,minutes:this.minutesLabel,seconds:this.secondsLabel,},redirect=shouldRedirect&&'disabled'!==this.redirect||false,url=this.redirect_url||'';if('undefined'!==typeof FLBuilder){redirect=false;} if(t.total<=0){clearInterval(FLBuilderCountdownIntervals[this.nodeID]);$.each(wrappers,function(type,element){element.find('.fl-countdown-unit-number').html('00');});if(!!redirect&&0<url.length){setTimeout(()=>{window.location.href=url;},1000);}}else{$.each(wrappers,function(type,element){element.find('.fl-countdown-unit-number').html(t[type]);var $el=element.find('.fl-countdown-unit-label');var label=parseInt(t[type])!=1?labels[type].plural:labels[type].singular;$el.html(label);});}},_setCircleCount:function(){var t=this._getTimeRemaining(this.timestamp),max={days:365,hours:24,minutes:60,seconds:60},circles={days:$(this.dateWrapper).find('svg'),hours:$(this.hoursWrapper).find('svg'),minutes:$(this.minutesWrapper).find('svg'),seconds:$(this.secondsWrapper).find('svg'),} $.each(circles,function(type,element){var $circle=element.find('.fl-number'),r=$circle.attr('r'),circle=Math.PI*(r*2),val=t[type],total=max[type],stroke=(1-(val / total))*circle;$circle.css({strokeDashoffset:stroke});});},_initCountdown:function(){var self=this;if(0===$(this.wrapperClass).length){return;} clearInterval(FLBuilderCountdownIntervals[this.nodeID]);FLBuilderCountdownIntervals[this.nodeID]=setInterval(function(){self._setTimeRemaining(true);if(self.type=='circle'){self._setCircleCount();}},1000);this._setTimeRemaining('always'===self.redirect);if(this.type=='circle'){this._setCircleCount();}},};})(jQuery);;(function($){$(function(){new FLBuilderCountdown({id:'10462h8akmnq',time:'2024-12-02T00:00:00+00:00',type:'circle',redirect:'disabled',redirect_url:'',});});})(jQuery);(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof FLBuilderLayoutConfig.breakpoints[breakpoint]!==undefined){this.breakpointWidth=FLBuilderLayoutConfig.breakpoints[breakpoint];} else{this.breakpointWidth=FLBuilderLayoutConfig.breakpoints.medium;}} if(Number(header.attr('data-sticky'))){this.header.data('original-top',this.header.offset().top);this.win.on('resize',$.throttle(500,$.proxy(this._initSticky,this)));this._initSticky();}},this));}},_initSticky:function(e){var header=$('.fl-builder-content[data-type=header]'),windowSize=this.win.width(),makeSticky=false;makeSticky=this._makeWindowSticky(windowSize);if(makeSticky||(this.breakpointWidth>0&&windowSize>=this.breakpointWidth)){this.win.on('scroll.fl-theme-builder-header-sticky',$.proxy(this._doSticky,this));if(e&&'resize'===e.type){if(this.header.hasClass('fl-theme-builder-header-sticky')){this._doSticky(e);} this._adjustStickyHeaderWidth();} if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var winTop=Math.floor(this.win.scrollTop()),headerTop=Math.floor(this.header.data('original-top')),hasStickyClass=this.header.hasClass('fl-theme-builder-header-sticky'),hasScrolledClass=this.header.hasClass('fl-theme-builder-header-scrolled'),beforeHeader=this.header.prevAll('.fl-builder-content'),bodyTopPadding=parseInt(jQuery('body').css('padding-top')),winBarHeight=$('#wpadminbar').length?$('#wpadminbar').outerHeight():0,headerHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(this.hasAdminBar&&this.win.width()>600){winTop+=Math.floor(winBarHeight);} if(winTop>headerTop){if(!hasStickyClass){if(e&&('scroll'===e.type||'smartscroll'===e.type)){this.header.addClass('fl-theme-builder-header-sticky');if(this.overlay&&beforeHeader.length){this.header.css('top',winBarHeight);}} if(!this.overlay){this._adjustHeaderHeight();}}} else if(hasStickyClass){this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');} this._adjustStickyHeaderWidth();if(winTop>headerTop){if(!hasScrolledClass){this.header.addClass('fl-theme-builder-header-scrolled');}}else if(hasScrolledClass){this.header.removeClass('fl-theme-builder-header-scrolled');} this._flyoutMenuFix(e);},_initFlyoutMenuFix:function(e){var header=this.header,menuModule=header.closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),isPushMenu=menuModule.hasClass('fl-menu-responsive-flyout-push')||menuModule.hasClass('fl-menu-responsive-flyout-push-opacity'),isOverlay=menuModule.hasClass('fl-menu-responsive-flyout-overlay'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',flyoutParent=header.parent().is('header')?header.parent().parent():header.parent();isFullWidth=this.win.width()===header.width(),flyoutLayout='',activePos=250,headerPos=0;if(!flyoutMenu.length){return;} if(this.win.width()>header.parent().width()){headerPos=(this.win.width()-header.width())/ 2;} if(isOverlay){activePos=headerPos;} else if(isPushMenu){activePos=activePos+headerPos;} flyoutMenu.data('activePos',activePos);if(isPushMenu){flyoutLayout='push-'+flyoutPos;} else if(isOverlay){flyoutLayout='overlay-'+flyoutPos;} if(isPushMenu&&!$('html').hasClass('fl-theme-builder-has-flyout-menu')){$('html').addClass('fl-theme-builder-has-flyout-menu');} if(!flyoutParent.hasClass('fl-theme-builder-flyout-menu-'+flyoutLayout)){flyoutParent.addClass('fl-theme-builder-flyout-menu-'+flyoutLayout);} if(!header.hasClass('fl-theme-builder-flyout-menu-overlay')&&isOverlay){header.addClass('fl-theme-builder-flyout-menu-overlay');} if(!header.hasClass('fl-theme-builder-header-full-width')&&isFullWidth){header.addClass('fl-theme-builder-header-full-width');} else if(!isFullWidth){header.removeClass('fl-theme-builder-header-full-width');} menuModule.on('click','.fl-menu-mobile-toggle',$.proxy(function(event){if(menuModule.find('.fl-menu-mobile-toggle.fl-active').length){$('html').addClass('fl-theme-builder-flyout-menu-active');event.stopImmediatePropagation();} else{$('html').removeClass('fl-theme-builder-flyout-menu-active');} this._flyoutMenuFix(event);},this));},_flyoutMenuFix:function(e){var header=this.header,menuModule=$(e.target).closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',menuOpacity=menuModule.find('.fl-menu-mobile-opacity'),isScroll='undefined'!==typeof e&&'scroll'===e.handleObj.type,activePos='undefined'!==typeof flyoutMenu.data('activePos')?flyoutMenu.data('activePos'):0,headerPos=(this.win.width()-header.width())/ 2,inactivePos=headerPos>0?activePos+4:254;if(!flyoutMenu.length){return;} if(this.overlay){return;} if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} if(menuOpacity.length){if(header.hasClass('fl-theme-builder-header-sticky')){if('0px'===menuOpacity.css('left')){menuOpacity.css('left','-'+headerPos+'px');}} else{menuOpacity.css('left','');}}},_adjustStickyHeaderWidth:function(){if($('body').hasClass('fl-fixed-width')){var parentWidth=this.header.parent().width();if(this.win.width()>=992){this.header.css({'margin':'0 auto','max-width':parentWidth,});} else{this.header.css({'margin':'','max-width':'',});}}},_adjustHeaderHeight:function(){var beforeHeader=this.header.prevAll('.fl-builder-content'),beforeHeaderHeight=0,beforeHeaderFix=0,headerHeight=Math.floor(this.header.outerHeight()),bodyTopPadding=parseInt($('body').css('padding-top')),wpAdminBarHeight=0,totalHeaderHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(beforeHeader.length){$.each(beforeHeader,function(){beforeHeaderHeight+=Math.floor($(this).outerHeight());});beforeHeaderFix=2;} if(this.hasAdminBar&&this.win.width()<=600){wpAdminBarHeight=Math.floor($('#wpadminbar').outerHeight());} totalHeaderHeight=Math.floor(beforeHeaderHeight+headerHeight);if(headerHeight>0){var headerParent=this.header.parent(),headerParentTopPadding=0;if($(headerParent).is('body')){headerParentTopPadding=Math.floor(headerHeight-wpAdminBarHeight);}else{headerParentTopPadding=Math.floor(headerHeight-bodyTopPadding-wpAdminBarHeight);} $(headerParent).css('padding-top',(headerParentTopPadding-beforeHeaderFix)+'px');this.header.css({'-webkit-transform':'translate(0px, -'+totalHeaderHeight+'px)','-ms-transform':'translate(0px, -'+totalHeaderHeight+'px)','transform':'translate(0px, -'+totalHeaderHeight+'px)'});}},_initShrink:function(e){if(this.win.width()>=this.breakpointWidth){this.win.on('scroll.fl-theme-builder-header-shrink',$.proxy(this._doShrink,this));this._setImageMaxHeight();if(this.win.scrollTop()>0){this._doShrink();}}else{this.header.parent().css('padding-top','0');this.win.off('scroll.fl-theme-builder-header-shrink');this._removeShrink();this._removeImageMaxHeight();}},_doShrink:function(e){var winTop=this.win.scrollTop(),headerTop=this.header.data('original-top'),headerHeight=this.header.data('original-height'),shrinkImageHeight=this.header.data('shrink-image-height'),windowSize=this.win.width(),makeSticky=this._makeWindowSticky(windowSize),hasClass=this.header.hasClass('fl-theme-builder-header-shrink');if(this.hasAdminBar){winTop+=32;} if(makeSticky&&(winTop>headerTop+headerHeight)){if(!hasClass){this.header.addClass('fl-theme-builder-header-shrink');this.header.find('img').each(function(i){var image=$(this),maxMegaMenu=image.closest('.max-mega-menu').length,imageInLightbox=image.closest('.fl-button-lightbox-content').length,imageInNavMenu=image.closest('li.menu-item').length;if(!(imageInLightbox||imageInNavMenu||maxMegaMenu)){image.css('max-height',shrinkImageHeight);}});this.header.find('.fl-row-content-wrap').each(function(){var row=$(this);if(parseInt(row.css('padding-bottom'))>5){row.addClass('fl-theme-builder-header-shrink-row-bottom');} if(parseInt(row.css('padding-top'))>5){row.addClass('fl-theme-builder-header-shrink-row-top');}});this.header.find('.fl-module-content').each(function(){var module=$(this);if(parseInt(module.css('margin-bottom'))>5){module.addClass('fl-theme-builder-header-shrink-module-bottom');} if(parseInt(module.css('margin-top'))>5){module.addClass('fl-theme-builder-header-shrink-module-top');}});}}else if(hasClass){this.header.find('img').css('max-height','');this._removeShrink();} if('undefined'===typeof(e)&&$('body').hasClass('fl-fixed-width')){if(!this.overlay){this._adjustHeaderHeight();}}},_removeShrink:function(){var rows=this.header.find('.fl-row-content-wrap'),modules=this.header.find('.fl-module-content');rows.removeClass('fl-theme-builder-header-shrink-row-bottom');rows.removeClass('fl-theme-builder-header-shrink-row-top');modules.removeClass('fl-theme-builder-header-shrink-module-bottom');modules.removeClass('fl-theme-builder-header-shrink-module-top');this.header.removeClass('fl-theme-builder-header-shrink');},_setImageMaxHeight:function(){var head=$('head'),stylesId='fl-header-styles-'+this.header.data('post-id'),styles='',images=this.header.find('.fl-module-content img');if($('#'+stylesId).length){return;} images.each(function(i){var 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