TY - JFULL AU - Sanjaykumar R. Patel and Parth R. Kayastha PY - 2018/3/ TI - Ultrasound Assisted Cooling Crystallization of Lactose Monohydrate T2 - International Journal of Chemical and Molecular Engineering SP - 57 EP - 61 VL - 12 SN - 1307-6892 UR - https://publications.waset.org/pdf/10008532 PU - World Academy of Science, Engineering and Technology NX - Open Science Index 134, 2018 N2 - α-lactose monohydrate is widely used in the pharmaceutical industries as an inactive substance that acts as a vehicle or a medium for a drug or other active substance. It is a byproduct of dairy industries, and the recovery of lactose from whey not only boosts the improvement of the economics of whey utilization but also causes a reduction in pollution as lactose recovery can reduce the BOD of whey by more than 80%. In the present study, levels of process parameters were kept as initial lactose concentration (30-50% w/w), sonication amplitude (20-40%), sonication time (2-6 hours), and crystallization temperature (10-20 oC) for the recovery of lactose in ultrasound assisted cooling crystallization. In comparison with cooling crystallization, the use of ultrasound enhanced the lactose recovery by 39.17% (w/w). The parameters were optimized for the lactose recovery using Taguchi Method. The optimum conditions found were initial lactose concentration at level 3 (50% w/w), amplitude of sonication at level 2 (40%), the sonication time at level 3 (6 hours), and crystallization temperature at level 1 (10 °C). The maximum recovery was found to be 85.85% at the optimum conditions. Sonication time and the initial lactose concentration were found to be significant parameters for the lactose recovery. ER -