Effects of Rotigaptide and RIC on Ischemia Reperfusion Injury in the In Vitro Rabbit Heart

<!doctype html> <html lang="en"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <meta itemprop="name" content="Walsh Medical Media" /> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="google-site-verification" content="YjHsSGOfJVjTiVTf6S4LqoaspPRh3ErDWaq1RaXtrAY" /> <meta name="ROBOTS" content="INDEX,FOLLOW"> <meta name="googlebot" content="INDEX,FOLLOW"> <link rel="shortcut icon" href="/assets/images/ico.png" /> <link rel="canonical" href="https://www.walshmedicalmedia.com/open-access/effects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html"> <link rel="alternate" href="https://www.walshmedicalmedia.com/open-access/effects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html" hreflang="en-us"/> <link rel="stylesheet" type="text/css" href="/assets/lib/css/bootstrap.min.css"> <link rel="stylesheet" type="text/css" href="/assets/css/style.css"> <link rel="stylesheet" type="text/css" href="/assets/css/responsive.css"> <link rel="stylesheet" type="text/css" href="/assets/css/journalpage.css"> <link rel="stylesheet" href="https://pro.fontawesome.com/releases/v5.10.0/css/all.css" crossorigin="anonymous"/> <link href="/assets/lib/css/font/font.css" rel="stylesheet"> <script src="/assets/lib/js/jquery.min.js"></script> <script src="/assets/lib/js/bootstrap.bundle.min.js"></script>  <script src="/assets/lib/js/popper.min.js"></script> <script src="/assets/lib/js/bootstrap.min.js"></script>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-82GJ3LQ7V6"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-82GJ3LQ7V6'); </script> <script type="application/ld+json"> { "@context": "https://schema.org", "@type": "Organization", "url": "https://www.walshmedicalmedia.com/", "logo": "https://www.walshmedicalmedia.com/assets/images/walsh-medical-media-logo.png" } </script> <meta property="og:title" content="walsh medical media | journals | open access journals" /> <meta property="og:type" content="open access journals" /> <meta property="og:url" content="https://www.walshmedicalmedia.com/" /> <meta property="og:image" content="https://www.walshmedicalmedia.com/assets/images/walsh-medical-media-logo.png" /> <meta name="twitter:card" content="summary"> <meta name="twitter:site" content="@WalshMedical"> <meta name="twitter:title" content="Walsh Medical Media | Journals | Open Access Journals"> <meta name="twitter:description" content="Walsh Medical Media. is one of the leading international open access journals publishers covering clinical, medical, biological, pharmaceutical sciences, engineering, as well as management and technol"> <meta name="twitter:image" content="https://www.walshmedicalmedia.com/assets/images/walsh-medical-media-logo.png">  <script> !function(f,b,e,v,n,t,s){if(f.fbq)return;n=f.fbq=function(){n.callMethod? n.callMethod.apply(n,arguments):n.queue.push(arguments)};if(!f._fbq)f._fbq=n; n.push=n;n.loaded=!0;n.version='2.0';n.queue=[];t=b.createElement(e);t.async=!0; t.src=v;s=b.getElementsByTagName(e)[0];s.parentNode.insertBefore(t,s)}(window, document,'script','//connect.facebook.net/en_US/fbevents.js'); fbq('init', '297919997051754'); fbq('track', "PageView"); </script> <title>Effects of Rotigaptide and RIC on Ischemia Reperfusion Injury in the In Vitro Rabbit Heart</title> <meta name="keywords" content="Ischemia; Reperfusion; Myocardial infarction; Connexin 43; Rotigaptide; Remote ischemic"> <meta name="description" content="Effects of Rotigaptide and RIC on Ischemia Reperfusion Injury in the In Vitro Rabbit Heart, Salman R, Johnsen J, Lassen TR, Hansen RS, Bøtker HE and Schmidt MR*"> <meta name="citation_publisher" content="Walsh Medical Media"/> <meta name="citation_journal_title" content="Cardiovascular Pharmacology: Open Access"> <meta name="citation_title" content="Effects of Rotigaptide and RIC on Ischemia Reperfusion Injury in the In Vitro Rabbit Heart"> <meta name="citation_author" content="Salman R"/> <meta name="citation_author" content="Johnsen J"/> <meta name="citation_author" content="Lassen TR"/> <meta name="citation_author" content="Hansen RS"/> <meta name="citation_author" content="Bøtker HE"/> <meta name="citation_author" content="Schmidt MR"/> <meta name="citation_year" content="2017"> <meta name="citation_volume" content="6"> <meta name="citation_issue" content="2"> <meta name="citation_doi" content="10.4172/2329-6607.1000209"> <meta name="citation_issn" content="2329-6607"> <meta name="citation_online_date" content="0000/00/00"/> <meta name="citation_firstpage" content="1"> <meta name="citation_lastpage" content="6"> <meta name="citation_abstract" content="Background: Remote Ischemic Preconditioning (rIPC) and the antiarrhythmic peptide analogue, Rotigaptide (ZP123), protects against myocardial ischemia-reperfusion injury through potentially similar mechanisms. We aimed to study whether the cardioprotective effects of Rotigaptide and rIPC interacts. Methods: We used male New Zealand White rabbit hearts mounted in a Langendorff system and exposed to 30 min of global no-flow ischemia and 120 min of reperfusion. A total of 48 rabbits were randomized into 6 groups: control (n=6), Rotigaptide (1 μM) before (n=9) or after (n=9) ischemia, rIPC (n=7), rIPC+Rotigaptide before (n=9) or after (n=8) ischemia. rIPC was induced by four cycles of 5-min ischemia and reperfusion on the left hind limb achieved by intermittent tourniquet occlusion. Primary endpoint was infarct size measured by tetrazolium staining. Results: rIPC reduced infarct size compared to controls. Rotigaptide alone did not affect infarct size irrespective of administration before ischemia or during reperfusion. The combination of rIPC and Rotigaptide before ischemia reduced infarct size, whereas the effect of rIPC was abrogated by Rotigaptide when administered during reperfusion. No significant changes in hemodynamic recovery were observed when compared to control group. Conclusion: In contrast to in vivo rIPC, in vitro Rotigaptide did not yield cardioprotection in our rabbit model, but Rotigaptide attenuated the effect of rIPC. "> <meta name="citation_fulltext_html_url" content="https://www.walshmedicalmedia.com/open-access/effects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html"> <meta name="citation_pdf_url" content="https://www.walshmedicalmedia.com/open-access/effects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-in-vitrorabbit-heart-.pdf"> <meta name="citation_abstract_html_url" content="https://www.walshmedicalmedia.com/abstract/effects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html"> <script type="text/javascript"> function openimage( theURL, winName, features ) { window.open( theURL, winName, features ); } </script> </head> <body> <header class="header-view"> <div class="container"> <div class="row"> <div class="col-lg-12 col-md-12 d-flex flex-column justify-content-center"> <nav class="navbar navbar-expand-lg p-0"> <a href="https://www.walshmedicalmedia.com/" title="Walsh Medical Media"><img src="/assets/images/walsh-medical-media-logo.png" alt="Walsh Medical Media"></a> <button class="navbar-toggler toggle-view" type="button" data-bs-toggle="collapse" data-bs-target="#mainNavbar"> <i class="fa fa-bars" aria-hidden="true"></i> </button> <div class="collapse navbar-collapse justify-content-end" id="mainNavbar"> <ul class="navbar-nav header-links"> <li class="nav-item"> <a class="nav-link" href="https://www.walshmedicalmedia.com/" title="Click here">Home</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle own-journal" href="#" id="navbarDropdownMenuLink" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Journals </a> <ul class="dropdown-menu custom-dropdown" aria-labelledby="navbarDropdownMenuLink"> <li><a class="dropdown-item" href="https://www.walshmedicalmedia.com/scientific-journals-list.html" title="Click here">A-Z Journals</a></li> <li><a class="dropdown-item" href="https://www.walshmedicalmedia.com/open-access-journals-list.html" title="Click here">Browse By Subject</a></li> </ul> </li> <li class="nav-item"> <a class="nav-link" href="https://www.walshmedicalmedia.com/publish-with-us.html" title="Click here">Publish With Us</a> </li> <li class="nav-item"> <a class="nav-link" href="https://www.walshmedicalmedia.com/contact-us.html" title="Click here">Contact Us</a> </li> </ul> <ul class="navbar-nav manuscript"> <li class="nav-item"> <a class="nav-link" href="https://www.walshmedicalmedia.com/submissions/cardiovascular-pharmacology.html" title="Click here">Submit Manuscript <i class="fa fa-long-arrow-right px-2" aria-hidden="true"></i></a> </li> </ul> <div id="google_translate_element"></div> </div> </nav> </div> </div> </div> </header> <section class="journal-navbar" id="sticky-navbar"> <div class="container"> <div class="col-md-12 py-4"> <div class="journal-heading-issn"> <h1>Cardiovascular Pharmacology: Open Access</h1> <p>ISSN: 2329-6607</p> </div> </div> </div>  <header class="journal-navbar"> <div class="container"> <div class="row"> <div class="col-lg-12 col-md-12"> <nav class="navbar navbar-expand-lg p-0"> <button class="navbar-toggler journal-toggle-view" type="button" data-bs-toggle="collapse" data-bs-target="#customNavbar"> <i class="fa fa-bars" aria-hidden="true"></i> </button> <div class="collapse navbar-collapse" id="customNavbar"> <ul class="navbar-nav journal-navbar-list"> <li class="nav-item"> <a class="nav-link" href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology.html" title="Click here">Journal Home</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownMenuLink" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Editorial panel </a> <ul class="dropdown-menu journal-custom-dropdown" aria-labelledby="navbarDropdownMenuLink"> <li><a class="dropdown-item" href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/editor-in-chief.html" title="Click here">Editor-in-chief</a></li> <li><a class="dropdown-item" href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/editorial-board.html" title="Click here">Editor Board</a></li> </ul> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownMenuLink" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Instructions for Authors </a> <ul class="dropdown-menu journal-custom-dropdown" aria-labelledby="navbarDropdownMenuLink"> <li><a class="dropdown-item" href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/instructionsforauthors.html" title="Click here">Instructions for Authors</a></li> <li><a class="dropdown-item" href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/ethical-malpractices.html" title="Click here">Publication ethics & malpractice statement</a></li> </ul> </li> <li class="nav-item"> <a class="nav-link" href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/submit-manuscript.html" title="Click here">Submit Manuscript</a> </li> <li class="nav-item"> <a class="nav-link" href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/inpress.html" title="Articles in process" style="text-transform:inherit;">Articles in process</a> </li>  <li class="nav-item"> <a class="nav-link" href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/archive.html" title="Click here">Archive</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownMenuLink" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Special Issues </a> <ul class="dropdown-menu journal-custom-dropdown" aria-labelledby="navbarDropdownMenuLink"> <li><a class="dropdown-item" href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/guidelines.html" title="Click here">Guidelines</a></li> <li><a class="dropdown-item" href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/upcoming-special-issues.html" title="Click here">Upcoming Special Issues</a></li> </ul> </li> <li class="nav-item"> <a class="nav-link" href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/contact.html" title="Click here">Contact</a> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdownMenuLink" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Our Services </a> <ul class="dropdown-menu journal-custom-dropdown" aria-labelledby="navbarDropdownMenuLink"> <li><a class="dropdown-item" href="https://www.walshmedicalmedia.com/advertise.html" title="Click here">Advertise</a></li> <li><a class="dropdown-item" href="https://www.walshmedicalmedia.com/reprints.html" title="Click here">Reprints</a></li> <li><a class="dropdown-item" href="https://www.walshmedicalmedia.com/membership.html" title="Click here">Membership</a></li> <li><a class="dropdown-item" href="https://www.walshmedicalmedia.com/subscription.html" title="Click here">Subscription</a></li> </ul> </li> </ul> </div> </nav> </div> </div> </div> </header> </section> <script type="text/javascript"> function googleTranslateElementInit() { new google.translate.TranslateElement({pageLanguage: 'en'}, 'google_translate_element'); } </script> <script type="text/javascript" src="//translate.google.com/translate_a/element.js?cb=googleTranslateElementInit"></script> <section class="py-4 content"> <div class="container"> <div class="row"> <div class="col-lg-3 pt-3 order-last order-sm-first"> <a href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/awards-nomination.html" class="btn btn-info btn-block mb-3 border-0 border-left-4 border-info font-size-4 awards_link" ><i class="fa-light fa-award-simple"></i> Awards Nomination </a> <a href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology-online-visitors-readers-82.html" class="btn btn-warning btn-block mb-3 border-0 border-left-4 border-info font-size-4 reader_link"><i class="fas fa-book-reader"></i> 20+ Million Readerbase</a>  <div class="card shadow-sm sidebar mb-3"> <div class="list-group list-group-flush qr_code_image"> <img title="QR" src="https://chart.googleapis.com/chart?chs=185x185&cht=qr&chl=https%3A%2F%2Fwww.walshmedicalmedia.com%2Fopen-access%2Feffects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html&chld=M|0&icqrf=00b1e4" alt="Walsh Medical Media"/>  <nav class="nav nav-pills social-icons-footer sidebar_social_icons a-pl-0"> <a title="Share This Article" target="_blank" class="nav-link" rel="noopener" href="https://www.facebook.com/sharer.php?s=100&p[title]=Effects of Rotigaptide and RIC on Ischemia Reperfusion Injury in the <em>In Vitro</em> Rabbit Heart&p[url]=https%3A%2F%2Fwww.walshmedicalmedia.com%2Fopen-access%2Feffects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html"><img src="https://www.walshmedicalmedia.com/assets/socials/facebook.png" alt="Walsh Medical Media" /></a> <a title="Share This Article" target="_blank" class="nav-link" rel="noopener" href="https://web.whatsapp.com/send?text=https%3A%2F%2Fwww.walshmedicalmedia.com%2Fopen-access%2Feffects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html" title="Share This Article" target="_blank" class="nav-link"><img src="https://www.walshmedicalmedia.com/assets/socials/whatsapp.png" alt="Walsh Medical Media"/></a> <a title="Share This Article" target="_blank" class="nav-link" rel="noopener" href="https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fwww.walshmedicalmedia.com%2Fopen-access%2Feffects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html" title="Share This Article" target="_blank" class="nav-link"><img src="https://www.walshmedicalmedia.com/assets/socials/linkedin.png" alt="Walsh Medical Media"/></a> <a title="Share This Article" target="_blank" class="nav-link" rel="noopener" href="https://twitter.com/share?text=Effects of Rotigaptide and RIC on Ischemia Reperfusion Injury in the <em>In Vitro</em> Rabbit Heart&url=https%3A%2F%2Fwww.walshmedicalmedia.com%2Fopen-access%2Feffects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html" class="nav-link"><img src="https://www.walshmedicalmedia.com/assets/socials/twitter.png" alt="Walsh Medical Media" /></a> </nav>  </div> </div>  <div class="card mb-3"> <div class="card-header custom-header"> <h6><a target="_blank" href="https://scholar.google.com/citations?hl=en&user=FOiAzY0AAAAJ&scilu=&scisig=AMD79ooAAAAAYS8TBSHDMiyHBFlE4V1QPhsgoDXPe0t9&gmla=AJsN-F7GiO_DS7FT3CcDW2nhWIqnW2AYPgZvc9qDTkg5Rk98E01V_OerF0nW937HFBWVraP0jT1ZkzBsAEXka5bZkAOozOY_xjt-Z831UL672qf5oyKnbXo&sciund=13286380100147679330" title="Click here">Google Scholar citation report</a></h6> </div> <div class="card-body custom-body"> <h6 style="font-weight:bold;">Citations : 218</h6> <p><a target="_blank" href="https://scholar.google.com/citations?hl=en&user=FOiAzY0AAAAJ&scilu=&scisig=AMD79ooAAAAAYS8TBSHDMiyHBFlE4V1QPhsgoDXPe0t9&gmla=AJsN-F7GiO_DS7FT3CcDW2nhWIqnW2AYPgZvc9qDTkg5Rk98E01V_OerF0nW937HFBWVraP0jT1ZkzBsAEXka5bZkAOozOY_xjt-Z831UL672qf5oyKnbXo&sciund=13286380100147679330" title="Click here">Cardiovascular Pharmacology: Open Access received 218 citations as per Google Scholar report</a></p> <div class="card shadow-sm sidebar mb-3"> <a href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/citations.html" title="Click here"><img src="https://www.walshmedicalmedia.com/admin/citation-images/cardiovascular-pharmacology-open-access-citation.png" alt="Cardiovascular Pharmacology: Open Access" class="img-fluid p_rel" /></a> </div> </div> </div> <div class="card mb-3"> <div class="card-header custom-header"> <h6><a href="https://publons.com/journal/34135/cardiovascular-pharmacology-open-access/" target="_blank" title="Click here">Cardiovascular Pharmacology: Open Access peer review process verified at publons</a></h6> </div> <div class="card-body custom-body"> <a href="https://publons.com/journal/34135/cardiovascular-pharmacology-open-access/" target="_blank" title="Click here"><img src="https://www.walshmedicalmedia.com/admin/publon-images/cardiovascular-pharmacology-open-access-publon.png" alt="Flyer image" class="p_rel w-100" height="250px"/></a> </div> </div> <div class="card mb-3"> <div class="card-body custom-body p-0"> <div> <a href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/advertising.html" title="Click here"><img src="https://www.walshmedicalmedia.com/assets/images/tower-banner.jpg" alt="Flyer image" class="img-fluid p_rel" width="100%" /> <span class="p_abo cu_roundchip"> <span> <h5><span>25+</span> Million Website Visitors</h5> </span> </span> </a> </div> </div> </div>   <div class="card mb-3"> <div class="card-header custom-header"> <h6>Indexed In</h6> </div> <div class="card-body custom-body card-scroll"> <ul class="list-unstyled index-list"> <li><i class="fa fa-angle-right"></i> Open J Gate </li> <li><i class="fa fa-angle-right"></i> Cosmos IF </li> <li><i class="fa fa-angle-right"></i> RefSeek </li> <li><i class="fa fa-angle-right"></i> Hamdard University </li> <li><i class="fa fa-angle-right"></i> EBSCO A-Z </li> <li><i class="fa fa-angle-right"></i> OCLC- WorldCat </li> <li><i class="fa fa-angle-right"></i> Publons </li> <li><i class="fa fa-angle-right"></i> Geneva Foundation for Medical Education and Research </li> <li><i class="fa fa-angle-right"></i> Euro Pub </li> <li><i class="fa fa-angle-right"></i> Google Scholar </li> </ul> </div> <div class="card-footer custom-card-footer text-end"> <a href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/indexing.html">View More <i class="fa fa-long-arrow-right" aria-hidden="true"></i></a> </div> </div> <div class="card mb-3"> <div class="card-header custom-header"> <h6>Useful Links</h6> </div> <div class="card-body custom-body card-scroll"> <ul class="list-unstyled index-list"> <li><a href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/aim-and-scope.html" title="Click Here"><i class="fa fa-angle-right"></i> Aim and Scope</a></li> <li><a href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/peer-review-process.html" title="Click Here"><i class="fa fa-angle-right"></i> Peer Review Process</a></li>   <li><a href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/citations.html" title="Click Here"><i class="fa fa-angle-right"></i> Citations Report</a></li> <li><a href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/indexing.html" title="Click Here"><i class="fa fa-angle-right"></i> Indexing and Archiving</a></li> <li><a href="https://www.walshmedicalmedia.com/cardiovascular-pharmacology/archive.html" title="Click Here"><i class="fa fa-angle-right"></i> Table of Contents</a></li> <li><a href="https://www.walshmedicalmedia.com/submissions/cardiovascular-pharmacology.html" title="Click Here"><i class="fa fa-angle-right"></i> Submit Paper</a></li> <li><a href="https://www.walshmedicalmedia.com/peer-review-tracking/" title="Click Here"><i class="fa fa-angle-right"></i> Track Your Paper</a></li> <li><a href="https://www.walshmedicalmedia.com/funded-articles.html" title="Click Here"><i class="fa fa-angle-right"></i> Funded Work</a></li> </ul> </div> </div> <div class="card mb-3"> <div class="card-header custom-header"> <h6>Share This Page</h6> </div> <div class="card-body left-bar-social-links"> <ul class="nav"> <li><a class="nav-link" rel="noopener" href="https://www.facebook.com/sharer.php?u=https://www.walshmedicalmedia.com/open-access/effects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html" target="_blank" title="Share with Facebook"><i class="fab fa-facebook-f"></i></a></li> <li><a class="nav-link" rel="noopener" href="https://twitter.com/share?url=https://www.walshmedicalmedia.com/open-access/effects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html" target="_blank" title="Share with Twiter"><i class="fab fa-twitter"></i></a></li> <li><a class="nav-link" rel="noopener" href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.walshmedicalmedia.com/open-access/effects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html" target="_blank" title="Share with Linkedin"><i class="fab fa-linkedin-in"></i></a></li> <li><a class="nav-link" rel="noopener" href="https://pinterest.com/pin/create/button/?url=https://www.walshmedicalmedia.com/open-access/effects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html" target="_blank" title="Share with Pinterest"><i class="fab fa-pinterest-p"></i></a></li> <li><a class="nav-link" rel="noopener" href="https://www.blogger.com/blog-this.g?u=https://www.walshmedicalmedia.com/open-access/effects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-emin-vitroem-rabbit-heart-15868.html" target="_blank" title="Share with Blogger"><i class="fab fa-blogger-b"></i></a></li> </ul> </div> </div>   <div class="card mb-3"> <div class="card-header custom-header"> <h6>Journal Flyer</h6> </div> <div class="card-body custom-body"> <div> <img src="https://www.walshmedicalmedia.com/admin/flyers/cardiovascular-pharmacology-open-access-flyer.jpg" alt="Cardiovascular Pharmacology: Open Access" class="img-fluid" width='100%'/> </div> </div> </div>  <div class="card mb-3" align="center"> <a class="twitter-timeline" href="https://twitter.com/Cardio_pharma" data-width="450" data-height="300">Tweets by Cardio_pharma</a> <script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script> </div>  <div class="card mb-3"> <div class="card-header custom-header"> <h6>Open Access Journals</h6> </div> <div class="card-body custom-body card-scroll"> <ul class="list-unstyled index-list"> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/agri-and-aquaculture-journals.html" title="Click here"> Agri and Aquaculture </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/biochemistry-journals.html" title="Click here"> Biochemistry </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/bioinformatics-and-systems-biology-journals.html" title="Click here"> Bioinformatics & Systems Biology </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/business-and-management-journals.html" title="Click here"> Business & Management </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/chemistry-journals.html" title="Click here"> Chemistry </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/clinical-sciences-journals.html" title="Click here"> Clinical Sciences </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/engineering-journals.html" title="Click here"> Engineering </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/food-and-nutrition-journals.html" title="Click here"> Food & Nutrition </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/general-science-journals.html" title="Click here"> General Science </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/genetics-and-molecular-biology-journals.html" title="Click here"> Genetics & Molecular Biology </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/immunology-and-microbiology-journals.html" title="Click here"> Immunology & Microbiology </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/medical-sciences-journals.html" title="Click here"> Medical Sciences </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/neuroscience-and-psychology-journals.html" title="Click here"> Neuroscience & Psychology </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/nursing-and-health-care-journals.html" title="Click here"> Nursing & Health Care </a></li> <li><i class="fa fa-angle-right"></i><a href="https://www.walshmedicalmedia.com/pharmaceutical-sciences-journals.html" title="Click here"> Pharmaceutical Sciences </a></li> </ul> </div> <div class="card-footer custom-card-footer text-end"> <a href="https://www.walshmedicalmedia.com/open-access-journals-list.html">View More <i class="fa fa-long-arrow-right" aria-hidden="true"></i></a> </div> </div>  </div> <div class="col-12 col-sm-9 full-text"> <div class="row align-items-center justify-content-between"> <div class="col-12 col-sm-6"> <p class="text-muted mb-0"> Research Article - (2017) Volume 6, Issue 2 </p> </div> <div class="col-12 col-sm-6 text-right custom-column"> <ul class="list-unstyled abtract-view"> <li><a href="https://www.walshmedicalmedia.com/open-access/effects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-in-vitrorabbit-heart-.pdf" title="View PDF" class="btn btn-sm bg-green-600 rounded-50"><i class="fas fa-file-pdf"></i> View PDF</a></li> <li><a href="https://www.walshmedicalmedia.com/pdfdownload.php?download=open-access/effects-of-rotigaptide-and-ric-on-ischemia-reperfusion-injury-in-the-in-vitrorabbit-heart-.pdf&aid=88202" title="Download PDF" class="btn btn-sm bg-green-600 rounded-50"><i class="fas fa-download"></i> Download PDF</a></li> </ul> </div> </div> <h1 class="font-size-7 mt-2">Effects of Rotigaptide and RIC on Ischemia Reperfusion Injury in the <em>In Vitro</em> Rabbit Heart</h1>  <dl class="authors"> <dt class="mb-1 font-weight-normal"><a href="https://www.walshmedicalmedia.com/author-profile/salman-r-313605" title="Salman R " >Salman R</a><sup class="font-weight-normal"><a href="#a1">1</a></sup>, <a href="https://www.walshmedicalmedia.com/author-profile/johnsen-j-313609" title="Johnsen J " >Johnsen J</a><sup class="font-weight-normal"><a href="#a1">1</a></sup>, <a href="https://www.walshmedicalmedia.com/author-profile/lassen-tr-313612" title="Lassen TR " >Lassen TR</a><sup class="font-weight-normal"><a href="#a1">1</a></sup>, <a href="https://www.walshmedicalmedia.com/author-profile/hansen-rs-313614" title="Hansen RS " >Hansen RS</a><sup class="font-weight-normal"><a href="#a2">2</a></sup>, <a href="https://www.walshmedicalmedia.com/author-profile/boslashtker-he-313618" title="Bøtker HE " >Bøtker HE</a><sup class="font-weight-normal"><a href="#a1">1</a></sup><span style='color: rgb(51, 51, 51);font-weight: 400; text-decoration:none'> and </span><a href="https://www.walshmedicalmedia.com/author-profile/schmidt-mr-313623" title="Schmidt MR " >Schmidt MR</a><sup class="font-weight-normal"><a href="#a1">1</a></sup><sup><a href="#corr313623" style="font-size:13px; color:blue;">*</a></sup></dt><dd id="a1"><sup>1</sup>Department of Cardiology, Aarhus University Hospital, 8000 Aarhus N, Denmark</dd><dd id="a2"><sup>2</sup>Zealand Pharma A/S, Smedeland 36, 2600 Glostrup, Denmark</dd></dl>  <sup style="font-size:13px; color:blue;">*</sup><strong>Corresponding Author:</strong> <a id="corr313623" name="corr"></a>

CINXE.COM

Effects of Rotigaptide and RIC on Ischemia Reperfusion Injury in the In Vitro Rabbit Heart