CINXE.COM

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col-1"> <a href="/image-contest" class="level0">Image Calendar</a> <span class="level0 visible-xs">+</span><div class="menu-content"><div class="container"><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Image Calendar</div> <span class="sectitle-span">+</span><ul><li><a href="/image-contest">Image Contest</a></li><li><a href="/data-image-gallery">Data Image Gallery</a></li></ul></div></div></div></div></li></ul></div><div class="col-lg-1 col-md-1 col-sm-1 col-xs-12 header-search search__button "><div class="search-icon">Search</div><div class="clear"></div></div></div></div> </header></div><div class="region region-content"><div id="block-system-main" class="block block-system clearfix"><div class="content"><div class="page-main-container "><div class="banner-container sticky"> <img class="img-banner" src="https://acdbio.com/sites/default/files/science-banner.jpg"><h1 class="general-title">Akt Signaling Pathway</h1><h2 class="banner-sub-title-seo">RNAscope™ Applications</h2></div><div class="content-container container newapplication"><div id="node-126984" class="node node-application node-promoted" about="/science/applications/research-areas/akt-signaling-pathway" typeof="sioc:Item foaf:Document"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs application-bxslider" id="myTab"><li><a href="/science/applications/research-areas/wnt-%CE%B2-catenin-signaling-pathway">Wnt / β-Catenin Signaling Pathway</a></li><li><a href="/science/applications/research-areas/jak-stat-signaling-pathway">JAK STAT Signaling Pathway</a></li><li class="active"><a href="/science/applications/research-areas/akt-signaling-pathway" class="active">Akt Signaling Pathway</a></li></ul></div><div class="tab-content"><div id="tab0" class="tab-pane fade in active profile"><h1 class="top-profile">Akt Signaling Pathway</h1><div class="sample-image"><div class="loader-image-gallery"></div><div id="film_roll" class="sample-slider"><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/AKT1%20gene%20expressed%20in%20human%20liver%20cancer%20using%20RNAscope%202.0%20Assay%20Brown.jpg?itok=pGM07p5X" width="765" height="451" alt="AKT1 gene expressed in human liver cancer using RNAscope 2.0 Assay Brown"><p class="slider-below-text"> AKT1 gene expressed in human liver cancer using RNAscope 2.0 Assay Brown</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/AKT3%20gene%20expressed%20in%20human%20liver%20cancer%20using%20RNAscope%202.0%20Assay%20Brown.jpg?itok=O4TGYgvo" width="765" height="451" alt="AKT3 gene expressed in human liver cancer using RNAscope 2.0 Assay Brown"><p class="slider-below-text"> AKT3 gene expressed in human liver cancer using RNAscope 2.0 Assay Brown</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/Expression%20of%20BCR%20in%20Human%20Liver%20TMA%20sammple.jpg?itok=_76nJBqL" width="765" height="451" alt="Expression of BCR in Human Liver TMA sample"><p class="slider-below-text"> Expression of BCR in Human Liver TMA sample</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/Expression%20of%20CDC37%20gene%20in%20human%20liver%20cancer%20TMA%20sample.jpg?itok=our-D0tz" width="765" height="451" alt="Expression of CDC37 gene in human liver cancer TMA sample"><p class="slider-below-text"> Expression of CDC37 gene in human liver cancer TMA sample</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/Expression%20of%20HSP90%20gene%20in%20human%20liver%20cancer%20TMA%20sample%20.jpg?itok=ovTa19z1" width="765" height="451" alt="Expression of HSP90 gene in human liver cancer TMA sample "><p class="slider-below-text"> Expression of HSP90 gene in human liver cancer TMA sample</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/Expression%20of%20ILK%20gene%20in%20human%20liver%20cancer%20TMA%20sample.jpg?itok=RSohZ1gE" width="765" height="451" alt="Expression of ILK gene in human liver cancer TMA sample"><p class="slider-below-text"> Expression of ILK gene in human liver cancer TMA sample</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/Expression%20of%20JAK1%20gene%20in%20human%20liver%20cancer%20TMA%20sample.jpg?itok=J8y3xnDs" width="765" height="451" alt="Expression of JAK1 gene in human liver cancer TMA sample"><p class="slider-below-text"> Expression of JAK1 gene in human liver cancer TMA sample</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/Expression%20of%20NF-KappaB%20gene%20in%20human%20liver%20cancer%20TMA%20sample.jpg?itok=oDgPMrVr" width="765" height="451" alt="Expression of NF-KappaB gene in human liver cancer TMA sample"><p class="slider-below-text"> Expression of NF-KappaB gene in human liver cancer TMA sample</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/Expression%20of%20SYK%20gene%20in%20human%20liver%20cancer%20TMA%20sample.jpg?itok=fO7l2pYg" width="765" height="451" alt="Expression of SYK gene in human liver cancer TMA sample"><p class="slider-below-text"> Expression of SYK gene in human liver cancer TMA sample</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/Expression%20of%20WNK1%20gene%20in%20human%20liver%20cancer%20TMA%20sample.jpg?itok=0i7BrKXw" width="765" height="451" alt="Expression of WNK1 gene in human liver cancer TMA sample"><p class="slider-below-text"> Expression of WNK1 gene in human liver cancer TMA sample</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/Expression%20of%20INPP5D%20gene%20%28SHIP%29%20in%20human%20liver%20cancer%20TMA%20sample.jpg?itok=xs0JgH9R" width="765" height="451" alt="Expression of INPP5D gene (SHIP) in human liver cancer TMA sample"><p class="slider-below-text"> Expression of INPP5D gene (SHIP) in human liver cancer TMA sample</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/Expression%20of%20PTK2%20%28FAK%29%20in%20human%20liver%20cancer%20TMA%20sample.jpg?itok=eTNvd7ES" width="765" height="451" alt="Expression of PTK2 (FAK) in human liver cancer TMA sample"><p class="slider-below-text"> Expression of PTK2 (FAK) in human liver cancer TMA sample</p></div><div><img src="https://acdbio.com/sites/default/files/styles/film_roll_slider/public/Low%20expression%20of%20IKBKE%20gene%20%28IKK%29%20in%20human%20liver%20cancer%20TMA%20sample.jpg?itok=1D08KjBF" width="765" height="451" alt="Low expression of IKBKE gene (IKK) in human liver cancer TMA sample"><p class="slider-below-text"> Low expression of IKBKE gene (IKK) in human liver cancer TMA sample</p></div></div><style type="text/css"> .loader-image-gallery { position: absolute; left: 0px; top: 0px; width: 100%; height: 100%; z-index: 9999; background: url('/sites/default/files/loading_apple.gif') 50% 35% no-repeat rgb(249,249,249); background-size: 100px; opacity: .8; } .sample-image { position: relative; } </style> <script type="text/javascript"> jQuery(document).ready(function($) { // $('#film_roll').hide(); function preloader(){ $('.loader-image-gallery').hide(); $('#film_roll').show(); } window.onload = preloader; }); </script> </div><div class="profile-content application_node_126984"><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p><img alt="Akt Signaling Pathway " src="/sites/default/files/image002.jpg" style="margin: 0px auto; display: block;" /></p><p> </p><h4><strong>Pathway information and image are provided courtesy of <a href="https://www.rndsystems.com/">R&D Systems, a Bio-Techne Brand.</a> Much more in-depth information about this pathway is available on their website <a href="https://www.rndsystems.com/pathways/akt-signaling-pathway">Read more</a></strong></h4><p>Serine/threonine kinase Akt plays critical role in regulating diverse cellular functions including metabolism, growth, proliferation, survival, transcription and protein synthesis. There are three highly related isoforms of Akt (Akt1, Akt2 and Akt3), which share many substrates but isoform-specific Akt substrates have also been identified.</p><p>In cells, receptor tyrosin kinasese, integrins, B and T cell receptors, cytokine receptors, G-protein-coupled receptors and other stimuli induce phosphoinositide 3-kinase (PI3K) to produce phospha- tidylinositol (3,4,5) trisphosphates (PIP3) through activate factors such as Focal Adhesion Kinase (FAK), Integrin-Linked Kinase (ILK), B-Cell Receptor (BCR), Spleen Tyrosine Kinase (SKY) and Janus Kinase-1 (JAK1). PIP3 then harbors pleckstrin-homol- ogy (PH) domains of Akt. Akt is activated by Phosphoinositide-Dependent Kinase-1 (PDK1), mTORC2, Cell Division Cycle-37 (CDC37), Heat Shock Protein-90KD (HSP90) through phosphorylation, whereas Akt is dephosphorylated by tumor suppressor phosphatase and tensin homolog (PTEN) and SH2-Containing Inositol Phosphatase (SHIP).</p><p>Akt regulates cell growth through its effects on the TSC1/TSC2 complex and mTORC signaling. Akt contributes to cell proliferation through phosphorylation of the CDK inhibitors p21 and p27. Akt is a major mediator of cell survival through direct inhibition of pro-apoptotic signals generated by transcription factors like FoxO or inhibition of pro-apoptotic proteins like Bad. Akt activates I-KappaB Kinase (IKK), which ultimately leads to NF-KappaB activation and cell survival. In the presence of survival factors, Akt1 phosphorylates FKHRL1 (FOXO3), leading to the association of FKHRL1 with 14-3-3 proteins and its retention in the cytoplasm. WNK Lysine deficient Protein Kinase-1 (WNK1) is a physiologically relevant target of Insulin signaling through PI3K and Akt and functions as a negative regulator of Insulin-stimulated mitogenesis. Akt phosphorylates Yes-Associated Protein-1 (YAP), a transcription factor, which causes nuclear export and cytoplasmic localization. Akt also phosphorylates Androgen Receptor (AR) which causes a decrease in AR activity on the p21 promoter and cell cycle progression.</p></div></div></div><div class="view view-application view-id-application view-display-id-block_8 view-dom-id-a09b029d9225eac84a52787cb31c2b79"></div><div class="view view-application view-id-application view-display-id-block_9 view-dom-id-68a8ed010c6bc2942fd809b5497ca342"><div class="view-content"><style type="text/css"> .view-id-application.view-display-id-block_9 .row.immuno-watch { margin-top: 15px; margin-bottom: 15px; } </style></div></div></div><div class="sample-image"><div class="profile-bottom"></div></div><div id="animal-models"><div class="immuno-content animalmodels-bottom-wrap"><div class="animalmodels-bottom"><div class="container"><div class="row viruses"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"><div class="sec-title" style="line-height: 20.8px; border-bottom: none;">Akt Signaling Pathway</div><p style="line-height: 20.8px;">(Click on the gene name to access corresponding RNAscope™ Catalog Probes)</p><p style="line-height: 20.8px;"> </p><div class="row"><div class="col-lg-2 col-md-2 col-sm-2 col-xs-6" style="line-height: 20.8px;"><ul><li><a href="/search/site/%252A%252A/cms/probes/gene/AKT1">AKT1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/AKT1S1">AKT1S1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/AKT3">AKT3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/AR">AR</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/BCR">BCR</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/BAD">BAD</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/BCL2L1">BCL2L1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CBFA2T2">CBFA2T2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDC37">CDC37</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDK1">CDK1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDK11B">CDK11B</a></li></ul></div><div class="col-lg-2 col-md-2 col-sm-2 col-xs-6" style="line-height: 20.8px;"><ul><li><a href="/search/site/%252A%252A/cms/probes/gene/CDK12">CDK12</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDK16">CDK16</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDK17">CDK17</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDK18">CDK18</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDK20">CDK20</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDK4">CDK4</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDK5">CDK5</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDK9">CDK9</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDKN1A">CDKN1A</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDKN1B">CDKN1B</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDKN1C">CDKN1C</a></li></ul></div><div class="col-lg-2 col-md-2 col-sm-2 col-xs-6" style="line-height: 20.8px;"><ul><li><a href="/search/site/%252A%252A/cms/probes/gene/CDKN1CA">CDKN1CA</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDKN2A">CDKN2A</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/CDKN2B-AS1">CDKN2B-AS1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/Deptor">Deptor</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/E2F1">E2F1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/E2F3">E2F3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/EIF4B">EIF4B</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/EIF4E">EIF4E</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/EIF4EBP1">EIF4EBP1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/ERBB3">ERBB3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/FAK">FAK</a></li></ul></div><div class="col-lg-2 col-md-2 col-sm-2 col-xs-6" style="line-height: 20.8px;"><ul><li><a href="/search/site/%252A%252A/cms/probes/gene/FOXO1">FOXO1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/FOXO3">FOXO3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/GSK3B">GSK3B</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/IKK">IKK</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/ILK">ILK</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/JAK1">JAK1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MDM2">MDM2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MTOR">MTOR</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/MYC">MYC</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/NFK">NFK</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PDPK1">PDPK1</a></li></ul></div><div class="col-lg-2 col-md-2 col-sm-2 col-xs-6" style="line-height: 20.8px;"><ul><li><a href="/search/site/%252A%252A/cms/probes/gene/PIK3CA">PIK3CA</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PIK3CB">PIK3CB</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PIK3CD">PIK3CD</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PIK3CG">PIK3CG</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PIK3R1">PIK3R1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PINK1">PINK1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PTEN">PTEN</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/PTENP1">PTENP1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/RHEB">RHEB</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/RICTOR">RICTOR</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/RPTOR">RPTOR</a></li></ul></div><div class="col-lg-2 col-md-2 col-sm-2 col-xs-6" style="line-height: 20.8px;"><ul><li><a href="/search/site/%252A%252A/cms/probes/gene/SHIP">SHIP</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/SYK">SYK</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/THOR">THOR</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TPTE">TPTE</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TSC2">TSC2</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TSC22D1">TSC22D1</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TSC22D3">TSC22D3</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/TSC22D4">TSC22D4</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/WNK">WNK</a></li><li><a href="/search/site/%252A%252A/cms/probes/gene/YAP">YAP</a></li></ul></div></div><div class="clear" style="line-height: 20.8px;"> </div><div class="immapp-desp"><p>Search for additional genes in our  <a href="http://acdbio.com/rnascope%C2%AE-target-probes">Catalog Target Probe</a> or submit your sequence for a <a href="http://acdbio.com/target-probes-made-order">Made to Order Target Probe</a></p></div></div></div></div></div></div></div><div class="gene-search"><div 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more details in the Contact Sales form below</p></div><div class="needhelp-tab"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs" id="help-tictab"><li class="active"><a data-toggle="tab" href="#contactsales">Contact Sales</a></li><li><a data-toggle="tab" href="#contactsupport">Contact Support</a></li><li><a data-toggle="tab" href="#contactpharma">Contact Services</a></li><li><a data-toggle="tab" href="#contactinfo">Offices</a></li></ul></div><div class="tab-content"><div class="needhelp-tab-container tab-pane fade in active" id="contactsales"><div class="supportform-con"><div class="contact-tab-form supportform-con"> <script src="//info.bio-techne.com/js/forms2/js/forms2.min.js"></script> <form id="mktoForm_9816"></form> <script>MktoForms2.loadForm("//info.bio-techne.com", "584-XSF-168", 9816);</script> </div></div></div><div class="needhelp-tab-container tab-pane fade" id="contactsupport"><div class="supportform-con"><form action="https://proteinsimple--obtfull.my.salesforce.com/servlet/servlet.WebToCase?encoding=UTF-8" id="web-to-case1" method="POST"><div class="row"><div class="col-md-6"> <label for="fname">First Name</label> <input id="fname" maxlength="80" name="fname" size="20" type="text"></div><div class="col-md-6"> <label for="lname">Last Name</label> <input id="lname" maxlength="80" name="lname" size="20" type="text"></div></div><div class="row"><div class="col-md-6"> <label for="email">Email</label> <input id="email" maxlength="80" name="email" size="20" type="text"></div><div class="col-md-6"> <label for="phone">Phone</label> <input id="phone" maxlength="40" name="phone" size="20" type="text"></div></div><div class="row"><div class="col-md-6"> <label for="company">Institution / Company</label> <input id="company" maxlength="80" name="company" size="20" type="text"></div></div><div class="row"><div class="col-md-12"> <label for="description">Message</label> <textarea name="description"></textarea> </div></div><div class="row captcha"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"> <label>Type the characters that you see in the picture below</label> <input type="text" id="PageCaseCaptcha" disabled /> <a class="btnrefresh" onclick="DrawCaptcha();"></a></div></div><div class="row captcha"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"> <input type="text" class="case_captcha" id="PageCaseInput" name="case_captcha"/><div id="pagecasecaptcha-error"></div></div></div> <input type="submit" name="submit" style="float:left;" onclick="ValidCaptcha('pagecase');"><div class="clear"></div></form></div></div><div class="needhelp-tab-container tab-pane fade" id="contactinfo"><div class="supportform-con contact-info"><div class="row"><h3>Advanced Cell Diagnostics</h3><p>Our new headquarters office starting May 2016:</p><p>7707 Gateway Blvd. <br />Newark, CA 94560<br />Toll Free: 1 (877) 576-3636<br />Phone: (510) 576-8800<br />Fax: (510) 576-8798</p></div><div class="row"><p> </p><div class="row"><h3>Bio-Techne</h3><p>19 Barton Lane <br />Abingdon Science Park<br />Abingdon<br />OX14 3NB<br />United Kingdom<br />Phone 2: +44 1235 529449<br />Fax: +44 1235 533420</p><p> </p></div><div class="row"><h3>Advanced Cell Diagnostics China</h3><p>20F, Tower 3,<br />Raffles City Changning Office,<br />1193 Changning Road, Shanghai 200051</p><p>021-52293200<br /><a href="mailto:info.cn@bio-techne.com">info.cn@bio-techne.com</a><br />Web: <a href="http://www.acdbio.com/cn">www.acdbio.com/cn</a></p></div><div class="row"><p>For general information: <a href="mailto:Info.ACD@bio-techne.com">Info.ACD@bio-techne.com</a><br />For place an order: <a href="mailto:order.ACD@bio-techne.com">order.ACD@bio-techne.com</a><br />For product support: <a href="mailto:support.ACD@bio-techne.com">support.ACD@bio-techne.com</a><br />For career opportunities: <a href="mailto:hr.ACD@bio-techne.com">hr.ACD@bio-techne.com</a></p></div></div><div class="row" style="border-bottom: none;"><div class="col-md-6"> <a href="/about/distributors" class="meet-out-sales-team" title="See Distributors">See Distributors</a></div></div></div></div><div class="needhelp-tab-container tab-pane fade" id="contactpharma"><div class="supportform-con"><div class="contact-tab-form supportform-con"><form id="mktoForm_9817"></form> <script>MktoForms2.loadForm("//info.bio-techne.com", "584-XSF-168", 9817);</script> </div></div></div></div></div></div></div></div></div></div> <script type="text/javascript"> jQuery(document).ready(function($) { $("#web-to-case1").validate({ // Specify the validation rules rules: { fname: "required", lname: "required", phone:"required", email: { required: true, email: true }, company: "required", case_captcha: "required" }, // Specify the validation error messages messages: { fname: "Please enter your First Name", lname: "Please enter your Last Name", email: "Please enter your email address", phone: "Please enter your 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