Clinical Research with Mass Cytometry

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justify-content:center;"> <div class="Width30 px-3"><img alt="IMC App Note" src="/FluidigmSite_Assets/Area_of_Interest/translational-and-clinical-research/MC_appNoteThumb.webp" style="width:100%;" /></div> <div class="Width70 px-3"> <h2 class="color-secondary-blue"><strong>Applying CyTOF Solutions to Cancer Immunotherapy Clinical Trials</strong></h2> <h3>Unique high-content proteomics reveals predictive response, biomarker translation and mechanism of action</h3> <p>It is critical for immunotherapy clinical trials to attain a comprehensive understanding of the immune response to disease and to potential treatment. This in-depth knowledge better enables accurate identification of predictive markers, biomarker translation and understanding mechanism of action, all of which are important for efficient and effective clinical trial execution. CyTOF™ technology is uniquely positioned to facilitate this level of understanding.</p> <p style="margin-top:24px;"><a class="primary-btn" href="/c/MC/2024-11-MC_FORM_AppNote">Download the clinical trials app note</a></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_jump-links pimcore_area_content "> <div class="jump-links-container"> <div class="jump-links bg-very-light-gray w-100"> <div class="container"> <div class="row"> <div class="col d-flex align-items-center overflow-auto py-4"> <a class="font-15 fw-bold font-proxima-nova link-no-style color-primary-gray jump-link" href="#overview-anchor" data-anchor-link="overview-anchor">Overview</a> <a class="font-15 fw-bold font-proxima-nova link-no-style color-primary-gray jump-link" href="#webinars-anchor" data-anchor-link="webinars-anchor">Webinars</a> <a class="font-15 fw-bold font-proxima-nova link-no-style color-primary-gray jump-link" href="#customer-stories-anchor" data-anchor-link="customer-stories-anchor">Customer Stories</a> <a class="font-15 fw-bold font-proxima-nova link-no-style color-primary-gray jump-link" href="#blog-anchor" data-anchor-link="blog-anchor">Related Blog Posts</a> <a class="font-15 fw-bold font-proxima-nova link-no-style color-primary-gray jump-link" href="#nocytof-anchor" data-anchor-link="nocytof-anchor">No CyTOF? No problem.</a> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_container pimcore_area_content "> <div id="overview-anchor" class="py-5 "> <div class="container"> <div class="row"> <div class="col-12 col-lg-6"> <div class="pimcore_area_wysiwyg pimcore_area_content "> <div id="-anchor" class="row area-wysiwyg"> <div class="col"> <p><strong>CyTOF® technology has been adopted for use in dozens of clinical research trials around the world to investigate multiple areas of human disease to understand and improve prevention and therapeutics.</strong></p> <p>Here’s why:</p> <ul> <li>50-plus unique markers per panel maximize information from every precious patient sample.</li> <br /> <li>Cells stained with metal-tagged antibodies can be frozen, stored and shipped reliably.</li> <br /> <li>Panels are easier to adjust to accommodate new findings than those that are fluorescence-based.</li> <br /> <li>Multiple publications prove that CyTOF assays and instruments provide reliable and reproducible results.</li> </ul> <p> </p> <p>The use of mass cytometry and Imaging Mass Cytometry™ in clinical trials continues to steadily grow and be standardized across trials related to cancer immunotherapies.</p> <p><strong>Download the <a href="https://fluidigm.my.salesforce.com/sfc/p/700000009DAw/a/4u0000017ycP/fDi30lK5SOpLxGpHsD8FrOwo07zZpX.f.Aerho3STC8" target="_blank">CyTOF clinical trials flyer</a> </strong>to learn details about the network involved in standardization of CyTOF in clinical trials and more.</p> <h3><strong><a class="primary-btn-purple" href="https://fluidigm.my.salesforce.com/sfc/p/700000009DAw/a/4u0000017ycP/fDi30lK5SOpLxGpHsD8FrOwo07zZpX.f.Aerho3STC8" target="_blank">Download now</a></strong></h3> </div> </div> </div> </div> <div class="col-12 col-lg-6"> <div class="pimcore_area_wysiwyg pimcore_area_content "> <div id="-anchor" class="row area-wysiwyg"> <div class="col"> <div style="background:#f5f5f5; padding:20px;"> <h4><span class="color-secondary-blue">Growing adoption of CyTOF technology in National Clinical Trials</span></h4> <p><span class="font-15"><span style="color:#999999;">207 Trials as of June 2022</span></span></p> <br /> <img src="/FluidigmSite_Assets/PrdSrv-Tech_MassCytometry/Images/MC_ClinicalResearch_Graph_Cytof-NCT.png" style="width:100%;" /> <p><span class="font-15"><span style="color:#999999;">Sources: clinicaltrials.gov and various publications</span></span></p> <hr /> <h4><span class="color-secondary-blue"><span class="font-16">National Clinical Trials citing CyTOF technology by research area</span></span></h4> <span class="color-secondary-blue"> </span><img src="/FluidigmSite_Assets/PrdSrv-Tech_MassCytometry/Images/MC_ClinicalResearch_Graph_Cytof-reaserch_NCT.png" style="width:100%;" /> <p><span class="font-15"><span style="color:#999999;">*Includes allergy, cardiac disease, pulmonary disease and stem cell</span></span></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_vidyard-video pimcore_area_content "> <div id="customer-stories-anchor" class="vidyard-video py-5 bg-grad-blue"> <div class="container"> <div class="row bg-white"> <div class="col-lg-1 d-none d-lg-block"></div> <div class="col-12 col-lg-4 p-4 px-lg-0 d-flex align-items-center"> <div> <h3><span class="color-secondary-blue">CyTOF<span style="font-size:12px !important; vertical-align: super;">®</span> for drug development</span></h3> <p>Expand the questions you can ask and get the most from those small samples … Hear directly from CyTOF users about why they use mass cytometry for their immune profiling studies, from high-parameter needs in vaccine development to quantitative receptor analysis for drug development and immunotherapy testing. </p> </div> </div> <div class="col-lg-1 d-none d-lg-block"></div> <div class="col-12 col-lg-6 px-0"> <script src="https://fast.wistia.com/embed/medias/8cnxo382o8.jsonp" async></script><script 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color-primary-gray">WORKFLOW</h4> </div> <div class="row row-cols-1 row-cols-md-1 row-cols-lg-3 g-4"> <div class="col workflow-card"> <div class="card border-0 h-100"> <div class="card-top bg-magenta w-100 rounded-top d-flex justify-content-center align-items-center" style="height: 145px;"> <p class="step-number">1</p> <picture data-alt="" data-default-src="/FluidigmSite_Assets/Generic-Assets/Images/Icons-Workflows/image-thumb__9662__workflow/WorkflowIcon_MC_Step2.png"> <source srcset="/FluidigmSite_Assets/Generic-Assets/Images/Icons-Workflows/image-thumb__9662__workflow/WorkflowIcon_MC_Step2.png 1x, /FluidigmSite_Assets/Generic-Assets/Images/Icons-Workflows/image-thumb__9662__workflow/WorkflowIcon_MC_Step2@2x.png 2x" type="image/png" /> <img alt="" src="/FluidigmSite_Assets/Generic-Assets/Images/Icons-Workflows/image-thumb__9662__workflow/WorkflowIcon_MC_Step2.png" /> </picture> </div> <div class="card-body rounded-bottom"> <h3 class="color-grad-blue card-title pb-0 pt-1 mb-1"> Sample</h3> <p class="card-text pt-0"><p><strong>Sample types:</strong></p> <p>- Whole blood</p> <p>- PBMC</p> <p>- Bone marrow</p> <p>- Tissue digests</p> <p>- Tumor digests</p> </p> </div> </div> </div> <div class="col workflow-card"> <div class="card border-0 h-100"> <div class="card-top bg-magenta w-100 rounded-top d-flex justify-content-center align-items-center" style="height: 145px;"> <p class="step-number">2</p> <picture data-alt="" data-default-src="/FluidigmSite_Assets/Generic-Assets/Images/Icons-Workflows/image-thumb__11304__workflow/WorkflowIcon_Clinical_Step2.png"> <source srcset="/FluidigmSite_Assets/Generic-Assets/Images/Icons-Workflows/image-thumb__11304__workflow/WorkflowIcon_Clinical_Step2.png 1x, /FluidigmSite_Assets/Generic-Assets/Images/Icons-Workflows/image-thumb__11304__workflow/WorkflowIcon_Clinical_Step2@2x.png 2x" type="image/png" /> <img alt="" src="/FluidigmSite_Assets/Generic-Assets/Images/Icons-Workflows/image-thumb__11304__workflow/WorkflowIcon_Clinical_Step2.png" /> </picture> </div> <div class="card-body rounded-bottom"> <h3 class="color-grad-blue card-title pb-0 pt-1 mb-1"> Stain, store, barcode</h3> <p class="card-text pt-0"><p>- Stain samples at multiple sites or on different days</p> <p>- Store, freeze and ship samples to a centralized location</p> <p>- <a href="https://www.fluidigm.com/area-of-interest/sample-barcoding" tabindex="-1">Barcode</a> samples to combine in a single tube</p> </p> </div> </div> </div> <div class="col workflow-card"> <div class="card border-0 h-100"> <div class="card-top bg-magenta w-100 rounded-top d-flex justify-content-center align-items-center" style="height: 145px;"> <p class="step-number">3</p> <picture data-alt="" data-default-src="/FluidigmSite_Assets/Generic-Assets/Images/Icons-Workflows/image-thumb__9640__workflow/WorkflowIcon_CyTOFXT_Step4.png"> <source 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col-lg-3 mb-3"> <h2 class="text-uppercase">Webinars</h2> <div> </div> </div> <div class="col-12 col-lg-9"> <div class="row g-4 row-cols-1 row-cols-lg-2 row-cols-xl-3"> <div class="col"> <div class="bg-white rounded card-border px-4 py-3 h-100"> <h4 class="color-grad-blue">Cutting Edge Cytometry and Clinical Trials: A Case Study</h4> <div> <p><img alt="Caroline Roe, MLI" src="/FluidigmSite_Assets/Generic-Assets/Images/Speaker-Headshots/Headshot_Caroline-Roe_BW_Small.jpg" style="width: 140px; height: 140px;" /></p> <p><span class="font-15"><strong>Caroline Roe, MLI</strong><br /> Managing Director<br /> Cancer & Immunology Core<br /> Vanderbilt University</span></p> <p><a class="secondary-btn" href="https://standard-biotools.wistia.com/medias/e6tfpazr24" target="_blank">Watch now</a></p> </div> </div> </div> <div class="col"> <div class="bg-white rounded card-border px-4 py-3 h-100"> <h4 class="color-grad-blue">CyTOF in the Cancer Immune Monitoring and Analysis Centers (CIMAC): standardization and harmonization</h4> <div> <p><img alt="Holden Maecker, PhD" src="/FluidigmSite_Assets/Generic-Assets/Images/Speaker-Headshots/Headshot_Holden-Maecker_BW_Large.jpg" style="width: 140px; height: 140px;" /></p> <p><span class="font-15"><strong>Holden Maecker, PhD</strong><br /> Professor of Microbiology and Immunology<br /> Director of the Human Immune Monitoring Center, Stanford University</span></p> <p><a class="secondary-btn" href="https://standard-biotools.wistia.com/medias/02ln9dxhi9" target="_blank">Watch now</a></p> </div> </div> </div> <div class="col"> <div class="bg-white rounded card-border px-4 py-3 h-100"> <h4 class="color-grad-blue">Using mass cytometry to identify clinically relevant biological signatures in human health and disease</h4> <div> <p><img alt="Brice Gaudilliere, MD, PhD" src="/FluidigmSite_Assets/Generic-Assets/Images/Speaker-Headshots/Headshot_Brice-Gaudilliere_BW_Small.jpg" style="width: 140px; height: 140px;" /></p> <p><span class="font-15"><strong>Brice Gaudilliere, MD, PhD</strong><br /> Associate Professor, Departments of Anesthesiology, Perioperative & Pain Medicine and (by courtesy) of Pediatrics, Stanford University School of Medicine</span></p> <p><a class="secondary-btn" href="https://standard-biotools.wistia.com/medias/uj949t1fuw" target="_blank">Watch now</a></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_overlap-scroller pimcore_area_content "> <div id="customer-stories-anchor" class="bg-very-light-gray"> <div class="container-fluid pb-5 overlap-scroller "> <div class="row"> <div class="col-12 col-lg-3 pt-5 pe-2 pe-lg-3 d-flex flex-column justify-content-center "> <h2 class="text-uppercase color-primary-gray pt-0">Customer Stories</h2> <p>Learn more about how our customers are leveraging Standard BioTools™ technology</p> <p> </p> <a href="/resources/customer-stories" target="_self" title="VIEW ALL" class="primary-btn align-self-start mt-3" type="internal">VIEW ALL</a> </div> <div class="col-12 col-lg-9 card-container d-flex py-5 card-width-lg ps-0"> <span class="col autofocus" autofocus></span> <div class="col product-card small-p"> <div class="card border-0 h-100"> <div class="card-header px-4 bg-light-gray border-0"> <h4 class="pt-1 pb-0 color-primary-gray text-uppercase">Wendy Fantl, PhD</h4> </div> <div class="row g-0 rounded-bottom h-100"> <div class="col-lg-4 text-center"> <picture data-alt="Spotlight MC Fantl Wendy" data-default-src="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3216__card-thumbnail/Spotlight_MC_FantlWendy.jpg"> <source srcset="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3216__card-thumbnail/Spotlight_MC_FantlWendy.jpg 1x, /FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3216__card-thumbnail/Spotlight_MC_FantlWendy@2x.jpg 2x" type="image/jpeg" /> <img alt="Spotlight MC Fantl Wendy" title="Spotlight MC Fantl Wendy" src="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3216__card-thumbnail/Spotlight_MC_FantlWendy.jpg" /> </picture> </div> <div class="col-lg-8 d-flex flex-column"> <div class="card-body px-4 pt-4"> <h3 class="card-text pt-0">On the right path to better ovarian cancer diagnosis and treatment </h3> </div> <div class="card-footer border-0 px-4 pb-3 bg-white d-flex align-items-center justify-content-end mt-auto"> <a href="https://www.standardbio.com/resources/customer-stories/a-revelation-in-cancer-cell-behavior-the-nk-cell-story" class="secondary-btn">Learn more</a> </div> </div> </div> </div> </div> <div class="col product-card small-p"> <div class="card border-0 h-100"> <div class="card-header px-4 bg-light-gray border-0"> <h4 class="pt-1 pb-0 color-primary-gray text-uppercase">Lori Turner, PhD</h4> </div> <div class="row g-0 rounded-bottom h-100"> <div class="col-lg-4 text-center"> <picture data-alt="Spotlight MC LORI TURNER" data-default-src="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3213__card-thumbnail/Spotlight_MC_Lori.jpg"> <source srcset="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3213__card-thumbnail/Spotlight_MC_Lori.jpg 1x, /FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3213__card-thumbnail/Spotlight_MC_Lori@2x.jpg 2x" type="image/jpeg" /> <img alt="Spotlight MC LORI TURNER" title="Spotlight MC LORI TURNER" src="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3213__card-thumbnail/Spotlight_MC_Lori.jpg" /> </picture> </div> <div class="col-lg-8 d-flex flex-column"> <div class="card-body px-4 pt-4"> <h3 class="card-text pt-0">A quick pivot to COVID-19 research with CyTOF</h3> </div> <div class="card-footer border-0 px-4 pb-3 bg-white d-flex align-items-center justify-content-end mt-auto"> <a href="https://www.standardbio.com/resources/customer-stories/moving-forward-with-mass-cytometry-in-the-midst-of-the-pandemic" class="secondary-btn">Learn more</a> </div> </div> </div> </div> </div> <div class="col product-card small-p"> <div class="card border-0 h-100"> <div class="card-header px-4 bg-light-gray border-0"> <h4 class="pt-1 pb-0 color-primary-gray text-uppercase">Hema Kothari, PhD</h4> </div> <div class="row g-0 rounded-bottom h-100"> <div class="col-lg-4 text-center"> <picture data-alt="" data-default-src="/LegacySite_Assets/Images/Speaker%20Portraits/image-thumb__3940__card-thumbnail/Hema-Kothari_spotlight-thumb.png"> <source srcset="/LegacySite_Assets/Images/Speaker%20Portraits/image-thumb__3940__card-thumbnail/Hema-Kothari_spotlight-thumb.png 1x, /LegacySite_Assets/Images/Speaker%20Portraits/image-thumb__3940__card-thumbnail/Hema-Kothari_spotlight-thumb@2x.png 2x" type="image/png" /> <img alt="" src="/LegacySite_Assets/Images/Speaker%20Portraits/image-thumb__3940__card-thumbnail/Hema-Kothari_spotlight-thumb.png" /> </picture> </div> <div class="col-lg-8 d-flex flex-column"> <div class="card-body px-4 pt-4"> <h3 class="card-text pt-0">A lesson in how CyTOF technology can empower flexibility in research</h3> </div> <div class="card-footer border-0 px-4 pb-3 bg-white d-flex align-items-center justify-content-end mt-auto"> <a href="https://www.standardbio.com/resources/customer-stories/hema-kothari_covid-19-cardiovascular-disease-and-mass-cytometry" class="secondary-btn">Learn more</a> </div> </div> </div> </div> </div> <div class="col product-card small-p"> <div class="card border-0 h-100"> <div class="card-header px-4 bg-light-gray border-0"> <h4 class="pt-1 pb-0 color-primary-gray text-uppercase">Marcelo Sztein, MD</h4> </div> <div class="row g-0 rounded-bottom h-100"> <div class="col-lg-4 text-center"> <picture data-alt="Spotlight MC Marcelo" data-default-src="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3205__card-thumbnail/Spotlight_MC_MarceloSztein-1.jpg"> <source srcset="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3205__card-thumbnail/Spotlight_MC_MarceloSztein-1.jpg 1x, /FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3205__card-thumbnail/Spotlight_MC_MarceloSztein-1@2x.jpg 2x" type="image/jpeg" /> <img alt="Spotlight MC Marcelo" title="Spotlight MC Marcelo" src="/FluidigmSite_Assets/Rsrc_Customer_Stories/Images/Customers-Spotlight-photos/image-thumb__3205__card-thumbnail/Spotlight_MC_MarceloSztein-1.jpg" /> </picture> </div> <div class="col-lg-8 d-flex flex-column"> <div class="card-body px-4 pt-4"> <h3 class="card-text pt-0">Research focuses on infection, vaccination in humans</h3> </div> <div class="card-footer border-0 px-4 pb-3 bg-white d-flex align-items-center justify-content-end mt-auto"> <a href="https://www.standardbio.com/resources/customer-stories/uncovering-immunological-mechanisms-of-protection" class="secondary-btn">Learn more</a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_container pimcore_area_content "> <div id="blog-anchor" class="py-5 "> <div class="container"> <div class="row"> <div class="col"> <div class="pimcore_area_wysiwyg pimcore_area_content "> <div id="-anchor" class="row area-wysiwyg"> <div class="col"> <div class="sidebysideContainer bg-very-light-gray" style="padding:20px;"> <div class="Width25"><img src="/FluidigmSite_Assets/Generic-Assets/Images/Icons-Misc/Icon_BlogPost_BlueCircle-OutlineWhite.png" style="width:80%;" /></div> <div class="Width75 sidebysideRtItem"> <h3><span class="color-secondary-blue">RELATED BLOG POSTS</span></h3> <hr /> <ul> <li> <h3><a class="secondary-btn" href="/resources/blog-articles/2023/05/cytof-genome-project">Trillions of cells, hundreds of cell types, one collaborative effort</a></h3> <h5>Atlasing how so many cells work together to make us human</h5> <p><a class="primary-btn-purple" href="/resources/blog-articles/2023/05/cytof-genome-project">Read more</a></p> </li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="pimcore_area_featurette pimcore_area_content "> <div id="-anchor" class="featurette-circle bg-grad-blue color-white position-relative py-4 py-lg-5 "> <img class="featurette-image" src="/static/fluidigm/img/featurette-circle-bg.png" alt="background pattern"> <div class="container pt-2 pb-4 position-relative"> <div class="row "> <div class="d-none d-lg-block col-lg-1"></div> <div class="d-flex px-5 py-3 p-lg-0 col-12 col-lg-3 justify-content-center align-items-center"> <picture data-alt="" data-default-src="/FluidigmSite_Assets/Support/Images/image-thumb__13729__medium-circle/DiscoveryLab_MarkhamCIC-2.png"> <source 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Send us your samples and we will send you the data. </p> <div class="primary-btn-alt mt-3"> <a href="/services/discovery-lab" target="_blank" title="View now" class="align-self-start" type="internal">Learn more</a> </div> </div> <div class="d-none d-lg-block col-lg-1"></div> </div> </div> </div> </div> <div class="pimcore_area_snippets pimcore_area_content "> <div class="container py-5"> <div class="row"> <div class="col-12"> <h1 class="py-0"> </h1> <div> <p><strong>For Research Use Only. Not for use in diagnostic procedures.</strong> Patent and License Information: <a href="/legal/notices">www.standardbio.com/legal/notices</a>. Trademarks: <a href="/legal/trademarks">www.standardbio.com/legal/trademarks</a>. Any other trademarks are the sole property of their respective owners. ©2025 Standard BioTools Inc. 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