Neonatal sepsis

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href="https://gardp.org/take-action/" itemprop="url"><span itemprop='name' class='nav-items'>Take action</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-15353 list-inline-item"><a href="https://gardp.org/donate/" itemprop="url"><span itemprop='name' class='nav-items'>Donate to GARDP</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-21068 list-inline-item"><a href="https://gardp.org/requests-for-proposals/" itemprop="url"><span itemprop='name' class='nav-items'>RFP & licensing opportunities</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-15356 list-inline-item"><a href="https://gardp.org/learn-about-antibiotics/" itemprop="url"><span itemprop='name' class='nav-items'>Learn about antibiotics</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-15357 list-inline-item"><a href="https://gardp.org/work-with-us/" itemprop="url"><span itemprop='name' class='nav-items'>Work with us</span></a></li> </ul> </li> <li class="btn btn-color-p menu-item menu-item-type-custom menu-item-object-custom menu-item-21421 list-inline-item"><a href="https://powerofantibiotics.org/" itemprop="url"><span itemprop='name' class='nav-items'>PowerOfAntibiotics</span></a></li> </ul></div> </div> </div> </div> </nav> </header> <div id="main-container" class="hyphenate"> <div class="gardp-marquee"> <p>World AMR Awareness Week - 18 to 24 November 2024. Educate. Advocate. Act now.</p> </div><main id="content" role="main"> <section class="hero" style="background: linear-gradient(0deg, rgba(0,0,0,0.4), rgba(0,0,0,0.4)), url(https://gardp.org/wp-content/uploads/2022/10/About-Children_antibiotics.jpeg.webp) no-repeat center ; background-size: cover;; background-position: 45.52% 48.98%"> <div class="container"> <div class="row"> <div class="col-12 parallax-wrap content"> <div class="title mt-50"> <h1 style="text-align: center;"><span class="h1-big">Neonatal sepsis</span></h1> </div> <div class="btn-wrap mt-4 d-flex justify-content-center"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> <div data-rellax-zindex="5" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style=" top: 50%; left: 50%; z-index: 5;"> <img src="" alt=""/> </div> </div> </div> <div class="col-md-5 parallax-wrap parallax-wrap-desktop d-none d-md-block"> </div> </div> </div> </section> <section class="plain-text readmore-text" style="background: linear-gradient(0deg, rgba(13,31,48,0.4), rgba(13,31,48,0.4)), url(https://gardp.org/wp-content/uploads/2022/10/Global-GARDP-europe-bacteriay-antibiotics-safe-lives.jpg.webp) no-repeat center ; background-size: cover;" id=""> <div class="container"> <div class="row d-none d-md-flex"> <div class="col-6 col-md-9 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 white h2"></h1> </div> </div> </div> <div class="row"> <div class="col-12 col-md-9 parallax-wrap"> <div class="offset-md-1"> <div class="text-subtitle"> <h4 style="text-align: left;"><span class="white">Children and newborns are especially vulnerable to drug-resistant bacteria. <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02724-0/fulltext#%20" target="_blank" rel="noopener">1 in 5 deaths</a> caused by antibiotic resistance occur in children under the age of five, and up to 3 million <a href="https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(18)30063-8/fulltext" target="_blank" rel="noopener">newborns</a> get serious infections that lead to sepsis every year. GARDP is working to identify and develop new treatments for children, with special attention to newborns with sepsis, as well as to provide data to inform treatment guidelines for this vulnerable group. This page focuses on sepsis in newborns; for information on our paediatric development work, please see <a href="https://gardp.org/serious-bacterial-infections/">this page</a>. </span></h4> </div> </div> <div class="offset-md-1 btn-wrap mt-50-25"> </div> <div class="parallax-wrap-desktop d-none d-md-block"> <div data-rellax-zindex="5" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="2" style="top: 50%; left: 50%; width: 300px; "> <img src="https://gardp.org/wp-content/uploads/2022/10/Global-GARDP-europe-bacteriay-antibiotics-safe-lives-details.png.webp" alt=""/> </div> </div> <div class="parallax-wrap-mobile d-block d-md-none"> <div data-rellax-zindex="5" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="2" style=" top: 50%; left: 50%; width: 300px; z-index: 5;"> <img src="https://gardp.org/wp-content/uploads/2022/10/Global-GARDP-europe-bacteriay-antibiotics-safe-lives-details.png.webp" alt=""/> </div> <div data-rellax-zindex="10" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style=" top: -42%; left: 100%; width: 316px; z-index: 10;"> <img src="" alt=""/> </div> </div> </div> </div> </div> </section> <section class="facts" style="background-color: #e4f2ff" id=""> <div class="container"> <div class="row"> <div class="col-12 col-lg-6"> <h1 class="title mb-50 color-c h2">Programme goals</h1> </div> </div> <div class="numbers-items row parallax-wrap"> <div class="item col-12 col-xl-4"> <div class="img-wrapper"> <img width="900" height="600" src="https://gardp.org/wp-content/uploads/2022/10/Goal-1-1-900x600.jpg.webp" class="attachment-img900 size-img900" alt="Goal 1" style="object-position: 34.93% 38.71%" decoding="async" fetchpriority="high" srcset="https://gardp.org/wp-content/uploads/2022/10/Goal-1-1-900x600.jpg.webp 900w, https://gardp.org/wp-content/uploads/2022/10/Goal-1-1-500x333.jpg.webp 500w, https://gardp.org/wp-content/uploads/2022/10/Goal-1-1.jpg.webp 1400w" sizes="(max-width: 900px) 100vw, 900px"/> </div> <div class="number-wrap"> <span class="h3 w-80 color-b">Goal 1</span> </div> <div class="description dark"><p>Identify and improve access to new treatment regimens for newborns with life-threatening sepsis</p> </h1></div> </div> <div class="item col-12 col-xl-4"> <div class="img-wrapper"> <img width="900" height="600" src="https://gardp.org/wp-content/uploads/2022/10/Goal-2-900x600.jpg.webp" class="attachment-img900 size-img900" alt="Pakistan: Meeting Regular Health Needs Amid The Covid 19 Pandemi" style="object-position: 44.93% 41.54%" decoding="async" srcset="https://gardp.org/wp-content/uploads/2022/10/Goal-2-900x600.jpg.webp 900w, https://gardp.org/wp-content/uploads/2022/10/Goal-2-500x333.jpg.webp 500w, https://gardp.org/wp-content/uploads/2022/10/Goal-2.jpg.webp 1400w" sizes="(max-width: 900px) 100vw, 900px"/> </div> <div class="number-wrap"> <span class="h3 w-80 color-b">Goal 2</span> </div> <div class="description dark"><p>Contribute data to inform global guidelines for effective antibiotic use in newborns and children</p> </h1></div> </div> <div class="item col-12 col-xl-4"> <div class="img-wrapper"> <img width="900" height="506" src="https://gardp.org/wp-content/uploads/2024/03/DSC05688-900x506.jpg.webp" class="attachment-img900 size-img900" alt="Dsc05688" style="object-position: 50% 50%" decoding="async" srcset="https://gardp.org/wp-content/uploads/2024/03/DSC05688-900x506.jpg.webp 900w, https://gardp.org/wp-content/uploads/2024/03/DSC05688-500x281.jpg.webp 500w, https://gardp.org/wp-content/uploads/2024/03/DSC05688-1440x810.jpg.webp 1440w, https://gardp.org/wp-content/uploads/2024/03/DSC05688-2000x1125.jpg.webp 2000w" sizes="(max-width: 900px) 100vw, 900px"/> </div> <div class="number-wrap"> <span class="h3 w-80 color-b">Goal 3</span> </div> <div class="description dark"><p>In line with 2024-2028 GARDP Strategy, develop new treatments for carbapenem-resistant infections in newborns</p> </h1></div> </div> <div class="col-12 parallax-wrap-desktop d-none d-md-block"> </div> <div class="col-12 parallax-wrap-mobile d-block d-md-none"> </div> </div> <div class="row justify-content-center"> <div class="btn-wrap"> <div class="btn-wrap mt-4 d-flex justify-content-center"> <a href="https://gardp.org/gardp-strategy-2024-2028/" target="_blank" class="btn btn-color-c white">LEARN MORE</a> </div> </div> </div> </div> </section> <section class="highlight" style="background-color: #ffffff" id=""> <div class="container"> <div class="row flex-row-reverse"> <div class="col-lg-6"> <div class="text-box"> <h3><span class="color-b">“If we don’t carry out clinical trials specifically for children—as difficult as they may be to carry out—doctors won’t have the evidence they need to treat children, especially newborns. You can’t make assumptions based on adult data to treat a baby. With more data, we can identify the right drug at the right dosage to treat newborns with sepsis.”</span></h3><p> </p><p>– Sally Ellis, Children’s Antibiotics Project Leader, GARDP</p> </div> <div class="offset-md-1 btn-wrap mt-4"> </div> </div> <div class="col-lg-6 parallax-wrap"> <div class="img-wrap"> <img width="900" height="514" src="https://gardp.org/wp-content/uploads/2022/09/Childrens-Abx-Image-8-900x514.png.webp" class="image-content m-0 glow-white" alt="Childrens Abx Image 8" decoding="async" srcset="https://gardp.org/wp-content/uploads/2022/09/Childrens-Abx-Image-8-900x514.png.webp 900w, https://gardp.org/wp-content/uploads/2022/09/Childrens-Abx-Image-8-500x285.png.webp 500w, https://gardp.org/wp-content/uploads/2022/09/Childrens-Abx-Image-8.png.webp 1100w" sizes="(max-width: 900px) 100vw, 900px"/> <div class="parallax-wrap-desktop d-none d-md-block"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> </div> </div> </div> </div> </div> </section> <section class="cta" style="background: linear-gradient(0deg, rgba(13,31,48,0.4), rgba(13,31,48,0.4)), url(https://gardp.org/wp-content/uploads/2022/10/Global-GARDP-europe-bacteriay-antibiotics-safe-lives.jpg.webp) no-repeat center fixed; background-size: cover;" id=""> <div class="container"> <div class="row"> <div class="col-lg-6"> <h1 class="title mb-4 white default">Current projects</h1> <div class="center-text-custom"></div> </div> <div class="offset-lg-3 col-lg-3 d-flex align-items-center justify-content-start justify-content-md-center"> <div class="btn-wrap"> </div> <div class="parallax-wrap-desktop d-none d-md-block"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> </div> </div> </div> </div> </section> <section class="highlight" style="background-color: #ffffff" id=""> <div class="container"> <div class="row"> <div class="col-lg-6"> <h1 class="title mb-50 color-b h2">Trial of new and existing treatments for sepsis in newborns</h1> <div class="text-box"> <p>GARDP is running a trial (“NeoSep1”) to validate the doses of two antibiotics (fosfomycin and flomoxef) for use in newborns. It will also rank the safety and efficacy of three new combinations of older antibiotics (fosfomycin-amikacin, flomoxef-amikacin, and flomoxef-fosfomycin) against the current WHO-recommended standard of care (ampicillin-gentamicin). The trial will also consider how these combination treatments can best be used in hospital settings with varying levels of antibiotic resistance. The initial phase of the trial is taking place at hospitals in Kenya and South Africa. It will be expanded to other countries and regions with the aim to enrol 3,000+ newborns globally.</p> <div class="accordion"> <div class="accordion-component" id="accordionExample-1779772157"> <div class="card"> <div class="" id="headingOne"> <h2 class="mb-0"> <button class="btn btn-link btn-block text-left collapsed" type="button" data-toggle="collapse" data-target="#collapseOne-1779772157" aria-expanded="true" aria-controls="collapseOne-1779772157"> <svg width="22" height="15" viewBox="0 0 22 15" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M1 1L11 13.3077L21 1" stroke="#0D1F30" stroke-width="1.5"/> </svg> </button> </h2> </div> <div id="collapseOne-1779772157" class="collapse" aria-labelledby="headingOne" data-parent="#accordionExample-1779772157"> <div class="card-body p-0"> <p><p><span style="font-weight: 400;">The trial (“NeoSep1”) builds on findings from a </span><a href="https://gardp.org/gardp-study-reveals-that-babies-are-increasingly-dying-of-neonatal-sepsis-caused-by-drug-resistant-bacterial-infections/"><span style="font-weight: 400;">global observational study of sepsis in newborns</span></a><span style="font-weight: 400;"> carried out by GARDP together with St George’s, University of London; Penta–Child Health Research; the Medical Research Council Clinical Trials Unit at University College London, whose research team led in analysing the data; and the University of Antwerp. As one of the largest ever observational studies on the care of babies with sepsis, the study looked at over 3,200 newborns at 19 sites in 11 countries on 4 continents. It found that newborns with neonatal sepsis are increasingly dying because of drug-resistant bacterial infections. <span class="TextRun SCXW257738816 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="none"><span class="NormalTextRun SCXW257738816 BCX0">GARDP published the findings in </span></span><a href="https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1004179" target="_blank" rel="noopener"><span class="TextRun SCXW257738816 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW257738816 BCX0">PLOS Medicine</span></span></a> <span class="TextRun SCXW257738816 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="auto"><span class="NormalTextRun SCXW257738816 BCX0">in June 2023</span><span class="NormalTextRun SCXW257738816 BCX0"> and produced a</span></span> <a class="Hyperlink SCXW257738816 BCX0" href="https://gardp.org/wp-content/uploads/2022/10/GARDP-Neonatal-sepsis-study-results-2022.pdf" target="_blank" rel="noopener"><span class="TextRun Underlined SCXW257738816 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="none"><span class="NormalTextRun SCXW257738816 BCX0" data-ccp-charstyle="Hyperlink">report</span></span></a><span class="TextRun SCXW257738816 BCX0" lang="EN-GB" xml:lang="EN-GB" data-contrast="none"><span class="NormalTextRun SCXW257738816 BCX0"> in 2022.</span></span></span></p> <p> </p> <p><span style="font-weight: 400;">GARDP also carried out additional research leading up to the trial (“NeoSep1”). Previously, GARDP and its partners conducted a clinical trial that tested the safety and pharmacokinetics (i.e. how a drug interacts with the body) of fosfomycin in babies with neonatal sepsis. The results were published in </span><a style="letter-spacing: 0.32px;" href="https://adc.bmj.com/content/early/2022/01/24/archdischild-2021-322483" target="_blank" rel="noopener">Archives of Disease in Childhood</a><span style="font-weight: 400;"> and </span><a style="letter-spacing: 0.32px;" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212774/" target="_blank" rel="noopener">the Journal of Antimicrobial Chemotherapy.</a><span style="font-weight: 400;"> In addition, GARDP carried out studies in a laboratory that suggested that two older antibiotics in combination could be useful to treat neonatal sepsis and warranted further clinical investigation. See results in the </span><a style="letter-spacing: 0.32px;" href="https://academic.oup.com/jac/article/77/5/1334/6529341" target="_blank" rel="noopener">Journal of Antimicrobial Chemotherapy.</a><span style="font-weight: 400;"> </span></p> </p> </div> </div> </div> </div> </div> </div> <div class="offset-md-1 btn-wrap mt-4"> </div> </div> <div class="col-lg-6 parallax-wrap"> <div class="img-wrap"> <div class="parallax-wrap-desktop d-none d-md-block"> <div data-rellax-zindex="5" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="0" style="top: 85px; left: 50%; width: 503px; "> <img src="https://gardp.org/wp-content/uploads/2022/02/GARDP-antibiotics-keyvisual3-CMJN.png.webp" alt=""/> </div> <div data-rellax-zindex="10" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style="top: 100px; left: 87%; width: 200px; "> <img src="https://gardp.org/wp-content/uploads/2022/02/GARDP-vector_garphic-bacteria1-white-2@2x.png.webp" alt=""/> </div> <div data-rellax-zindex="15" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="2" style="top: 100px; left: 50%; width: 143px; "> <img src="https://gardp.org/wp-content/uploads/2022/10/62399653c8a3a25d48b1cea3_GARDP-bacteriaspheres-02.png.webp" alt=""/> </div> </div> <div class="parallax-wrap-mobile d-block d-md-none"> <div data-rellax-zindex="5" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="0" style=" top: -244px; left: 50; width: 503px; z-index: 5;"> <img src="https://gardp.org/wp-content/uploads/2022/02/GARDP-antibiotics-keyvisual3-CMJN.png.webp" alt=""/> </div> <div data-rellax-zindex="10" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style=" top: -144px; left: 50; width: 200px; z-index: 10;"> <img src="https://gardp.org/wp-content/uploads/2022/02/GARDP-vector_garphic-bacteria1-white-2@2x.png.webp" alt=""/> </div> <div data-rellax-zindex="15" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="2" style=" top: 100px; left: 50%; width: 143px; z-index: 15;"> <img src="https://gardp.org/wp-content/uploads/2022/10/62399653c8a3a25d48b1cea3_GARDP-bacteriaspheres-02.png.webp" alt=""/> </div> </div> </div> </div> </div> </div> </section> <section class="highlight" style="background-color: #00a1ad" id=""> <div class="container"> <div class="row flex-row-reverse"> <div class="col-lg-6"> <h1 class="title mb-50 dark h2">Development of new treatments for carbapenem-resistant infections in newborns</h1> <div class="text-box"> <p>Carbapenem-resistant <em>Acinetobacter baumannii</em> (CRAB) and carbapenem-resistant Enterobacterales (CREs) cause infections for which there are very limited or no safe and effective treatment options for children and newborns. With this project, GARDP will strive to improve outcomes for newborns by accelerating the development of new treatments for these drug-resistant infections. It will identify potential regimens for the use of cefiderocol and/or cefepime-taniborbactam for neonatal sepsis, with plans to initiate clinical development by 2028.</p> </div> <div class="offset-md-1 btn-wrap mt-4"> </div> </div> <div class="col-lg-6 parallax-wrap"> <div class="img-wrap"> <div class="parallax-wrap-desktop d-none d-md-block"> <div data-rellax-zindex="5" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="3" style="top: 100%; left: -7%; width: 192px; "> <img src="https://gardp.org/wp-content/uploads/2022/09/gardp-bacteria.png.webp" alt=""/> </div> <div data-rellax-zindex="10" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="0" style="top: -100px; left: -100%; width: 638px; "> <img src="https://gardp.org/wp-content/uploads/2022/10/GARDP-bacteria-access-antibiotics-e1665070035930.png.webp" alt=""/> </div> <div data-rellax-zindex="15" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style="top: -8%; left: -37%; width: 266px; "> <img src="https://gardp.org/wp-content/uploads/2022/10/623c661768a61ea4e071970c_GARDP-vector_garphic-bacteria1-white.png.webp" alt=""/> </div> </div> <div class="parallax-wrap-mobile d-block d-md-none"> <div data-rellax-zindex="5" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="3" style=" top: 100%; left: -7%; width: 192px; z-index: 5;"> <img src="https://gardp.org/wp-content/uploads/2022/09/gardp-bacteria.png.webp" alt=""/> </div> <div data-rellax-zindex="10" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="0" style=" top: -14%; left: 19; width: 0px; z-index: 10;"> <img src="https://gardp.org/wp-content/uploads/2022/10/GARDP-bacteria-access-antibiotics-e1665070035930.png.webp" alt=""/> </div> <div data-rellax-zindex="15" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style=" top: -8%; left: -37%; width: 266px; z-index: 15;"> <img src="https://gardp.org/wp-content/uploads/2022/10/623c661768a61ea4e071970c_GARDP-vector_garphic-bacteria1-white.png.webp" alt=""/> </div> </div> </div> </div> </div> </div> </section> <section class="highlight" style="background-color: #f3f8fe" id=""> <div class="container"> <div class="row flex-row-reverse"> <div class="col-lg-6"> <h1 class="title mb-50 color-b h2">Key milestones</h1> <div class="text-box"> <ul><li>2019: <strong>COMPLETED</strong> clinical trial to confirm the safety and pharmacokinetics (i.e. how a drug interacts with the body) of fosfomycin in babies with neonatal sepsis</li><li>2020: <strong>COMPLETED</strong> observational study on the care of babies with sepis involving over 3,200 newborns at 19 sites in 11 countries on 4 continents</li><li>2022: <strong>IDENTIFIED</strong> three potential combination treatments for neonatal sepsis</li><li>2023: <strong>LAUNCHED</strong> trial of new antibiotic combinations to treat neonatal sepsis in Kenya and South Africa</li></ul> </div> <div class="offset-md-1 btn-wrap mt-4"> </div> </div> <div class="col-lg-6 parallax-wrap"> <div class="img-wrap"> <img width="900" height="675" src="https://gardp.org/wp-content/uploads/2022/10/Neonatal2-e1667865661231-900x675.jpg.webp" class="image-content m-0" alt="Tanzania Nduta November 2018" decoding="async" srcset="https://gardp.org/wp-content/uploads/2022/10/Neonatal2-e1667865661231-900x675.jpg.webp 900w, https://gardp.org/wp-content/uploads/2022/10/Neonatal2-e1667865661231-500x375.jpg.webp 500w, https://gardp.org/wp-content/uploads/2022/10/Neonatal2-e1667865661231-1440x1080.jpg.webp 1440w, https://gardp.org/wp-content/uploads/2022/10/Neonatal2-e1667865661231-2000x1500.jpg.webp 2000w" sizes="(max-width: 900px) 100vw, 900px"/> <div class="parallax-wrap-desktop d-none d-md-block"> <div data-rellax-zindex="5" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="3" style="top: 86px; left: 6%; width: 282px; "> <img src="https://gardp.org/wp-content/uploads/2022/09/GroupGARDP-bacteria-white.png" alt=""/> </div> <div data-rellax-zindex="10" class="rellax bacteria-rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style="top: 100px; left: 44%; width: 160px; "> <img src="https://gardp.org/wp-content/uploads/2022/02/GARDP-bacteria-2@2x.png.webp" alt=""/> </div> </div> <div class="parallax-wrap-mobile d-block d-md-none"> <div data-rellax-zindex="5" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="3" style=" top: 86px; left: 6%; width: 282px; z-index: 5;"> <img src="https://gardp.org/wp-content/uploads/2022/09/GroupGARDP-bacteria-white.png" alt=""/> </div> <div data-rellax-zindex="10" class="rellax" data-rellax-percentage="0.001" data-rellax-speed="1" style=" top: 100px; left: 44%; width: 160px; z-index: 10;"> <img src="https://gardp.org/wp-content/uploads/2022/02/GARDP-bacteria-2@2x.png.webp" alt=""/> </div> </div> </div> </div> </div> </div> </section> <section class="plain-text" style="background: linear-gradient(0deg, rgba(0,0,0,0.4), rgba(0,0,0,0.4)), url(https://gardp.org/wp-content/uploads/2022/10/About-Children_antibiotics.jpeg.webp) no-repeat center ; background-size: cover;" id=""> <div class="container"> <div class="row d-none d-md-flex"> <div class="col-6 col-md-6 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 white h2">About children’s antibiotics</h1> </div> </div> <div class="col-6 col-md-6 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 white default"> </h1> </div> </div> </div> <div class="row"> <div class="col-12 col-md-6 parallax-wrap"> <div class="title d-flex d-md-none"> <div class="col-12 col-md-6 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 white h2">About children’s antibiotics</h1> </div> </div> </div> <div class="offset-md-1"> <div class="text-subtitle"> <p><span class="white">The development of new antibiotics is not keeping pace with rising antibiotic resistance. When it comes to developing treatments for children, the situation is even more dire.</span></p><p> </p><p><span class="white">According to a <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02724-0/fulltext#%20" target="_blank" rel="noopener">recent study</a>, in sub-Saharan Africa in 2019, more than half of the deaths caused by antibiotic-resistant infections occurred in children under five. Worldwide that same year, nearly 140,000 newborns died because of antibiotic-resistant infections, including pneumonia, sepsis, and meningitis. About <a href="https://apps.who.int/mediacentre/commentaries/antibiotic-resistant-bacteria/en/index.html" target="_blank" rel="noopener">40% of infections that cause neonatal sepsis in hospitals</a> are reported to be resistant to standard treatments.</span></p> </div> </div> <div class="offset-md-1 btn-wrap mt-50-25"> </div> <div class="parallax-wrap-desktop d-none d-md-block"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> </div> </div> <div class="col-12 col-md-6 parallax-wrap"> <div class="title d-flex d-md-none"> <div class="col-12 col-md-6 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 white default"> </h1> </div> </div> </div> <div class="offset-md-1"> <div class="text-subtitle"> <p><span class="white">It is not enough to develop new antibiotics based on trials in adults. Children’s bodies respond differently to antibiotics than adults’ bodies, so separate steps must be taken to confirm safety and effectiveness (including the proper dosage) of each new antibiotic treatment in children. Although regulatory agencies require that pharmaceutical companies evaluate new treatments for use in children, such steps are often delayed for years, if undertaken at all.</span></p><p> </p><p><span class="white">Doctors and policymakers need more data, treatments, and guidelines to care optimally for newborns and children with bacterial infections. GARDP is addressing this vital need.</span></p> </div> </div> <div class="offset-md-1 btn-wrap mt-50-25"> </div> <div class="parallax-wrap-desktop d-none d-md-block"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> </div> </div> </div> </div> </section> <section class="video" id="" style="background-color: #ffffff"> <div class="container"> <div class="row"> <div class="col-12"> <h1 class="title mb-25-50 color-b h2">Prioritizing antibiotic development in children</h1> <div uk-lightbox> <a href="" data-caption="Caption"></a> </div> <div class="container-fluid px-0 glow-color-b"> <div class="embed-responsive embed-responsive-16by9 z-depth-1-half"> <iframe id="video-iframe" class="embed-responsive-item" allow="autoplay; encrypted-media" src="https://www.youtube.com/embed/dzOJPBL12gw?enablejsapi=1" allowfullscreen></iframe> </div> </div> </div> </div> </div> </section> <section class="plain-text readmore-text" style="background-color: #e4f2ff" id=""> <div class="container"> <div class="row d-none d-md-flex"> <div class="col-6 col-md-9 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 color-b h2">Learn more</h1> </div> </div> </div> <div class="row"> <div class="col-12 col-md-9 parallax-wrap"> <div class="title d-flex d-md-none"> <div class="col-12 col-md-9 parallax-wrap"> <div class="row"> <h1 class="col-12 col-md-10 pl-0 title mb-50 color-b h2">Learn more</h1> </div> </div> </div> <div class="offset-md-1"> <div class="text-subtitle"> <ul><li>GARDP Policy Paper: <a href="https://gardp.org/publications/survive-and-thrive-improving-the-global-amr-response-for-healthier-children-and-newborns/">Survive and Thrive: Improving the Global AMR Response for Healthier Children and Newborns</a></li><li><span class="color-a"><span style="font-weight: 400;">GARDP </span><a href="https://gardp.org/wp-content/uploads/2022/10/GARDP-Neonatal-sepsis-study-results-2022.pdf" target="_blank" rel="noopener"><span style="font-weight: 400;">Report on the neonatal sepsis observational study</span></a><span style="font-weight: 400;"> (2022)</span></span></li><li><span class="color-a">Story: <a style="letter-spacing: 0.32px;" href="https://gardp.org/stories/photo-gallery-giving-newborns-a-better-chance/">Giving newborns a better chance</a></span></li><li><span class="color-a">Q&A: <a style="letter-spacing: 0.32px;" href="https://gardp.org/stories/qa-with-professor-sithembiso-velaphi-a-commitment-to-caring-for-newborns/">A commitment to caring for newborns</a> </span></li><li><span class="color-a">Story: <a style="letter-spacing: 0.32px;" href="https://gardp.org/stories/photo-gallery-in-india-transforming-the-care-of-babies-with-life-threatening-sepsis-2/">In India, transforming the care of babies with life-threatening sepsis</a></span></li></ul> </div> </div> <div class="offset-md-1 btn-wrap mt-50-25"> </div> <div class="parallax-wrap-desktop d-none d-md-block"> </div> <div class="parallax-wrap-mobile d-block d-md-none"> </div> </div> </div> </div> </section> <a id="waaw-logo" href="https://gardp.org/events/world-amr-awareness-week-2024/"><img src="https://gardp.org/wp-content/themes/gardp2/assets/img/png/waaw-stamp.png"/></a><a class="btn btn-color-c white hidden" id="take-action" href="https://gardp.org/donate/" target="_self">Donate</a></main> </div> <style>.fa{color:#fff!important}</style> <div class="modal fade" id="newsletter-modal" tabindex="-1" role="dialog" aria-labelledby="newsletter-modalLabel" aria-hidden="true"> <div class="modal-dialog modal-dialog-centered" role="document"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"> <span aria-hidden="true">×</span> </button> </div> <div class="modal-body"> <div class='fluentform ff-default fluentform_wrapper_6 ffs_default_wrap'><form data-form_id="6" id="fluentform_6" class="frm-fluent-form fluent_form_6 ff-el-form-top ff_form_instance_6_1 ff-form-loading ffs_default" data-form_instance="ff_form_instance_6_1" method="POST"><fieldset style="border: none!important;margin: 0!important;padding: 0!important;background-color: transparent!important;box-shadow: none!important;outline: none!important; 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Neonatal sepsis | GARDP