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The multi-species code accounts for equilibrium chemistry, non-uniform electroosmotic flow, and dispersion. Our modeling efforts for the latter are also presented. The goal of our work is to create an efficient, accurate, validated, and uniquely-capable electrophoresis simulation code available for free via the web to the microfluidics community.","publication_date":"2008,,","grobid_abstract_attachment_id":"119984098"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"A Fast and Accurate Isotachophoresis Simulation Code","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [33619649]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":119984098,"attachmentType":"pdf"}"><img alt="First page of “A Fast and Accurate Isotachophoresis Simulation Code”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/119984098/mini_magick20241203-1-di503q.png?1733253272" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">A Fast and Accurate Isotachophoresis Simulation Code</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="33619649" href="https://stanford.academia.edu/JuanSantiago"><img alt="Profile image of Juan Santiago" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Juan Santiago</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2008</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">3 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 126046793; 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if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">We developed a numerical code which allows fast and accurate simulation of isotachophoresis (ITP). The multi-species code accounts for equilibrium chemistry, non-uniform electroosmotic flow, and dispersion. Our modeling efforts for the latter are also presented. The goal of our work is to create an efficient, accurate, validated, and uniquely-capable electrophoresis simulation code available for free via the web to the microfluidics community.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":119984098,"attachmentType":"pdf","workUrl":"https://www.academia.edu/126046793/A_Fast_and_Accurate_Isotachophoresis_Simulation_Code"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":119984098,"attachmentType":"pdf","workUrl":"https://www.academia.edu/126046793/A_Fast_and_Accurate_Isotachophoresis_Simulation_Code"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="119984098" data-landing_url="https://www.academia.edu/126046793/A_Fast_and_Accurate_Isotachophoresis_Simulation_Code" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="26184104" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26184104/High_resolution_modeling_of_isotachophoresis_and_zone_electrophoresis">High-resolution modeling of isotachophoresis and zone electrophoresis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="13405734" href="https://independent.academia.edu/RueyYang">Ruey-Jen Yang</a></div><p class="ds-related-work--metadata ds2-5-body-xs">ELECTROPHORESIS, 2008</p><p class="ds-related-work--abstract ds2-5-body-sm">The space-time conservation element and solution element (CESE) method is applied to simulate the ITP and zone electrophoresis (ZE) separation phenomena. The CESE method expresses the governing equation in the integral form of the conservation law, and has a second-order accuracy in both space and time. The current results show that the CESE solutions for the ITP and ZE phenomena are more accurate than those obtained using conventional numerical schemes, which are characterized by serious numerical diffusion and oscillation. Furthermore, the CESE method suppresses the numerical oscillations or peaks observed in the results obtained using traditional second-order finite difference schemes. Finally, the results reveal that the CESE method accurately models the sharp boundaries between adjacent ITP samples under steady-state conditions. Overall, the results presented in this study demonstrate the numerical accuracy of the CESE method and confirm its applicability to the modeling of a range of electrophoretic phenomena.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"High-resolution modeling of isotachophoresis and zone electrophoresis","attachmentId":46508423,"attachmentType":"pdf","work_url":"https://www.academia.edu/26184104/High_resolution_modeling_of_isotachophoresis_and_zone_electrophoresis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/26184104/High_resolution_modeling_of_isotachophoresis_and_zone_electrophoresis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="80356506" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/80356506/Modeling_and_high_performance_simulation_of_electrophoretic_techniques_in_microfluidic_chips">Modeling and high performance simulation of electrophoretic techniques in microfluidic chips</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="10923745" href="https://conicet.academia.edu/FabioArielGuarnieri">Fabio Guarnieri</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Microfluidics and Nanofluidics, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">Electrophoretic separations comprise a group of analytical techniques such as capillary zone electrophoresis, isoelectric focusing, isotachophoresis, and free flow electrophoresis. These techniques have been miniaturized in the last years and now represent one of the most important applications of the lab-on-a-chip technology. A 3D and time-dependent numerical model of electrophoresis on microfluidic devices is presented. The model is based on the set of equations that governs electrical phenomena, fluid dynamics, mass transport, and chemical reactions. The relationship between the buffer characteristics (ionic strength and pH) and surface potential of channel walls is taken into consideration. Numerical calculations were performed by using PETSc-FEM, in a Python environment, employing high performance parallel computing. The method includes a set of last generation preconditioners and solvers, especially addressed to 3D microfluidic problems, which significantly improve the numerical efficiency in comparison with typical commercial software for multiphysics. In this work, after discussing two validation examples, the numerical prototyping of a microfluidic chip for twodimensional electrophoresis is presented.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Modeling and high performance simulation of electrophoretic techniques in microfluidic chips","attachmentId":86765857,"attachmentType":"pdf","work_url":"https://www.academia.edu/80356506/Modeling_and_high_performance_simulation_of_electrophoretic_techniques_in_microfluidic_chips","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/80356506/Modeling_and_high_performance_simulation_of_electrophoretic_techniques_in_microfluidic_chips"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="72750459" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/72750459/Numerical_and_experimental_study_of_dispersion_dynamics_in_isotachophoresis">Numerical and experimental study of dispersion dynamics in isotachophoresis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33619649" href="https://stanford.academia.edu/JuanSantiago">Juan Santiago</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2009</p><p class="ds-related-work--abstract ds2-5-body-sm">We present an analytical, numerical and experimental study of advective dispersion in isotachophoresis (ITP). We analyse the dynamics of the concentration field of a focused analyte in peak mode ITP. The analyte distribution is subject to electromigration, diffusion and advective dispersion. Advective dispersion results from strong internal pressure gradients caused by non-uniform electro-osmotic flow (EOF). Analyte dispersion strongly affects the sensitivity and resolution of ITP-based assays. We perform axisymmetric time-dependent numerical simulations of fluid flow, diffusion and electromigration. We find that analyte properties contribute greatly to dispersion in ITP. Analytes with mobility values near those of the trailing (TE) or leading electrolyte (LE) show greater penetration into the TE or LE, respectively. Local pressure gradients in the TE and LE then locally disperse these zones of analyte penetration. Based on these observations, we develop a one-dimensional analytical model of the focused sample zone. We treat the LE, TE and LE-TE interface regions separately and, in each, assume a local Taylor-Aris-type effective dispersion coefficient. We also performed well-controlled experiments in circular capillaries, which we use to validate our simulations and analytical model. Our model allows for fast and accurate prediction of the area-averaged sample distribution based on known parameters including species mobilities, EO mobility, applied current density and channel dimensions. This model elucidates the fundamental mechanisms underlying analyte advective dispersion in ITP and can be used to optimize detector placement in detection-based assays.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Numerical and experimental study of dispersion dynamics in isotachophoresis","attachmentId":83907169,"attachmentType":"pdf","work_url":"https://www.academia.edu/72750459/Numerical_and_experimental_study_of_dispersion_dynamics_in_isotachophoresis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/72750459/Numerical_and_experimental_study_of_dispersion_dynamics_in_isotachophoresis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="72750491" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/72750491/Microfluidic_Isotachophoresis_Theory_and_Applications">Microfluidic Isotachophoresis: Theory and Applications</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33619649" href="https://stanford.academia.edu/JuanSantiago">Juan Santiago</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2021</p><p class="ds-related-work--abstract ds2-5-body-sm">Isotachophoresis (ITP) is a versatile electrophoretic technique which can be used for sample preconcentration, separation, purification, and control and acceleration of chemical reactions. Although the basic technique is nearly a century old and widely used, there has been a persistent need for an easily approachable, succinct, and rigorous review of ITP theory and analysis. This is important as interest and adoption of the technique has grown over the last two decades, especially because of its implementation into microfluidics and integration with on-chip chemical and biochemical assays. We here provide a review of ITP theory with a strong emphasis on steady and unsteady transport starting from physicochemical first principles including conservation of species, conservation of current, the approximation of charge neutrality, and pH equilibrium of weak electrolytes. We combine these generally applicable (to all types of ITP) theoretical discussions with applications of ITP in the f...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Microfluidic Isotachophoresis: Theory and Applications","attachmentId":81554541,"attachmentType":"pdf","work_url":"https://www.academia.edu/72750491/Microfluidic_Isotachophoresis_Theory_and_Applications","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/72750491/Microfluidic_Isotachophoresis_Theory_and_Applications"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="63504439" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/63504439/Open_source_simulation_tool_for_electrophoretic_stacking_focusing_and_separation">Open source simulation tool for electrophoretic stacking, focusing, and separation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33619649" href="https://stanford.academia.edu/JuanSantiago">Juan Santiago</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Chromatography A, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">We present the development, formulation, and performance of a new simulation tool for electrophoretic preconcentration and separation processes such as capillary electrophoresis, isotachophoresis, and field amplified sample stacking. The code solves the one-dimensional transient advection-diffusion equations for multiple multivalent weak electrolytes (including ampholytes) and includes a model for pressuredriven flow and Taylor-Aris dispersion. The code uses a new approach for the discretization of the equations, consisting of a high resolution compact scheme which is combined with an adaptive grid algorithm. We show that this combination allows for accurate resolution of sharp concentration gradients at high electric fields, while at the same time significantly reducing the computational time. We demonstrate smooth, stable, and accurate solutions at current densities as high as 5000 A/m 2 using only 300 grid points, and a 75-fold reduction in computational time compared with equivalent uniform grid techniques. The code is available as an open source for free at http://microfluidics.stanford.edu.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Open source simulation tool for electrophoretic stacking, focusing, and separation","attachmentId":75915074,"attachmentType":"pdf","work_url":"https://www.academia.edu/63504439/Open_source_simulation_tool_for_electrophoretic_stacking_focusing_and_separation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/63504439/Open_source_simulation_tool_for_electrophoretic_stacking_focusing_and_separation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="15626511" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15626511/Simul_5_Free_dynamic_simulator_of_electrophoresis">Simul 5 – Free dynamic simulator of electrophoresis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42417116" href="https://independent.academia.edu/VHru%C5%A1ka">Vlastimil Hruška</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34802067" href="https://cuni.academia.edu/BohuslavGa%C5%A1">Bohuslav Gaš</a></div><p class="ds-related-work--metadata ds2-5-body-xs">ELECTROPHORESIS, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">We introduce the mathematical model of electromigration of electrolytes in free solution together with free software Simul, version 5, designed for simulation of electrophoresis. The mathematical model is based on principles of mass conservation, acidbase equilibria, and electroneutrality. It accounts for any number of multivalent electrolytes or ampholytes and yields a complete picture about dynamics of electromigration and diffusion in the separation channel. Additionally, the model accounts for the influence of ionic strength on ionic mobilities and electrolyte activities. The typical use of Simul is: inspection of system peaks (zones), stacking and preconcentrating analytes, resonance phenomena, and optimization of separation conditions, in either CZE, ITP, or IEF. Electrophoresis 2006, 27, 984-991</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Simul 5 – Free dynamic simulator of electrophoresis","attachmentId":43020370,"attachmentType":"pdf","work_url":"https://www.academia.edu/15626511/Simul_5_Free_dynamic_simulator_of_electrophoresis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/15626511/Simul_5_Free_dynamic_simulator_of_electrophoresis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="25882861" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/25882861/Model_and_verification_of_electrokinetic_flow_and_transport_in_a_micro_electrophoresis_device">Model and verification of electrokinetic flow and transport in a micro-electrophoresis device</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="49637200" href="https://independent.academia.edu/PeterEhrhard">Peter Ehrhard</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Lab on a Chip, 2005</p><p class="ds-related-work--abstract ds2-5-body-sm">We investigate the electrokinetic flow and transport within a micro-electrophoresis device. A mathematical model is set up, which allows to perform two-dimensional, time-dependent finite-element simulations. The model reflects the dominant features of the system, namely electroosmosis, electrophoresis, externally-applied electrical potentials, and equilibrium chemistry. For the solution of the model equations we rely on numerical simulations of the core region, while the immediate wall region is treated analytically at leading order. This avoids extreme refinements of the numerical grid within the EDL. An asymptotic matching of both solutions and subsequent superposition, nevertheless, provides an approximation for the solution in the entire domain. The results of the simulations are verified against experimental observation and show good agreement.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Model and verification of electrokinetic flow and transport in a micro-electrophoresis device","attachmentId":46248617,"attachmentType":"pdf","work_url":"https://www.academia.edu/25882861/Model_and_verification_of_electrokinetic_flow_and_transport_in_a_micro_electrophoresis_device","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/25882861/Model_and_verification_of_electrokinetic_flow_and_transport_in_a_micro_electrophoresis_device"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="94386313" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/94386313/Simulation_of_1d_and_2d_electrophoretic_separations_in_microfluidics_chips">Simulation of 1d and 2d electrophoretic separations in microfluidics chips</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43123151" href="https://independent.academia.edu/PabloAKler">Pablo A. Kler</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2009</p><p class="ds-related-work--abstract ds2-5-body-sm">Electrophoretic separations comprise a group of analytical techniques such as capillary zone electrophoresis (CZE), isoelectric focusing (IEF), isotachophoresis (ITP) and free ﬂow electrophoresis (FFE). In all cases, separation is based on the dissimilar mobility of ionic species under the action of an external electric ﬁeld. These techniques, which are widely used in chemical and biochemical analysis, have been miniaturized in the last years and now represent one of the most important applications of the lab-on-a-chip technology. In a previous work, a generalized numerical model of electrophoresis on microﬂuidic devices was presented. The model is based on the set of equations that governs electrical phenomena (Poisson equation), ﬂuid dynamics (Navier-Stokes equations), mass transport (Nerst-Planck equation) and chemical reactions. Also the relationship between the buffer characteristics (ionic strength, pH) and surface potential of channel walls is taken into consideration. In thi...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Simulation of 1d and 2d electrophoretic separations in microfluidics chips","attachmentId":96857134,"attachmentType":"pdf","work_url":"https://www.academia.edu/94386313/Simulation_of_1d_and_2d_electrophoretic_separations_in_microfluidics_chips","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/94386313/Simulation_of_1d_and_2d_electrophoretic_separations_in_microfluidics_chips"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="53678875" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/53678875/Generalized_Numerical_Model_for_the_Simulation_of_Electrophoretic_Methods_in_Microfluidic_Chips">Generalized Numerical Model for the Simulation of Electrophoretic Methods in Microfluidic Chips</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="118015330" href="https://independent.academia.edu/CBerli">Claudio Berli</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Electrophoretic methods are separation techniques based on the mobility of ions under the action of an external electric field. These techniques, which are widely used in chemical and biochemical analysis, have been miniaturized in the last years and now represent one of the most important applications of the lab-on-a-chip technology. In this work, a generalized numerical model of electrophoresis on microfluidic devices is presented. The model is based on the set of equations that governs electrical phenomena (Poisson equation), fluid dynamics (Navier-Stokes equations), mass transport (Nerst-Planck equation) and chemical reactions. The model is said to be generalized because it covers different techniques such as capillary eletrophoresis and isoelectric focusing, and allows to simulate processes involving multiple analytes and complex electrolytes buffers. Moreover, the relationship between the buffer characteristics (ionic strength, pH) and physicochemical properties of channel walls is taken into consideration. The numerical simulation is carried out by using PETSC-FEM (Portable, Extensible Toolkit for Scientific Computation-Finite Elements Method), in a Python environment developed at CIMEC using high performance parallel computing and solving techniques based on domain decomposition methods. Finally, examples of interest involving electrophoresis on chips are considered as study cases.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Generalized Numerical Model for the Simulation of Electrophoretic Methods in Microfluidic Chips","attachmentId":70410361,"attachmentType":"pdf","work_url":"https://www.academia.edu/53678875/Generalized_Numerical_Model_for_the_Simulation_of_Electrophoretic_Methods_in_Microfluidic_Chips","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/53678875/Generalized_Numerical_Model_for_the_Simulation_of_Electrophoretic_Methods_in_Microfluidic_Chips"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="72750381" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/72750381/Sample_dispersion_in_isotachophoresis">Sample dispersion in isotachophoresis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33619649" href="https://stanford.academia.edu/JuanSantiago">Juan Santiago</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Fluid Mechanics, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">We present an analytical, numerical and experimental study of advective dispersion in isotachophoresis (ITP). We analyse the dynamics of the concentration field of a focused analyte in peak mode ITP. The analyte distribution is subject to electromigration, diffusion and advective dispersion. Advective dispersion results from strong internal pressure gradients caused by non-uniform electro-osmotic flow (EOF). Analyte dispersion strongly affects the sensitivity and resolution of ITP-based assays. We perform axisymmetric time-dependent numerical simulations of fluid flow, diffusion and electromigration. We find that analyte properties contribute greatly to dispersion in ITP. Analytes with mobility values near those of the trailing (TE) or leading electrolyte (LE) show greater penetration into the TE or LE, respectively. Local pressure gradients in the TE and LE then locally disperse these zones of analyte penetration. Based on these observations, we develop a one-dimensional analytical...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Sample dispersion in isotachophoresis","attachmentId":83907452,"attachmentType":"pdf","work_url":"https://www.academia.edu/72750381/Sample_dispersion_in_isotachophoresis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/72750381/Sample_dispersion_in_isotachophoresis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":119984098,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":119984098,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_119984098" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="15522467" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15522467/Microfluidic_isotachophoresis_A_review">Microfluidic isotachophoresis: A review</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34676293" href="https://utas.academia.edu/PetrSmejkal">Petr Smejkal</a></div><p class="ds-related-work--metadata ds2-5-body-xs">ELECTROPHORESIS, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Microfluidic isotachophoresis: A review","attachmentId":43121543,"attachmentType":"pdf","work_url":"https://www.academia.edu/15522467/Microfluidic_isotachophoresis_A_review","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/15522467/Microfluidic_isotachophoresis_A_review"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="28459747" data-sort-order="default"><a class="ds-related-work--title 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experiments","attachmentId":48808151,"attachmentType":"pdf","work_url":"https://www.academia.edu/28459747/Binary_oscillatory_cross_flow_electrophoresis_Theory_and_experiments","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/28459747/Binary_oscillatory_cross_flow_electrophoresis_Theory_and_experiments"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="31163849" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/31163849/Isotachophoresis_at_pH_extremes_Theory_and_experimental_validation">Isotachophoresis at pH extremes: Theory and experimental validation</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="29517100" href="https://polimi.academia.edu/pierrighetti">pier righetti</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Electrophoresis, 1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Isotachophoresis at pH extremes: Theory and experimental validation","attachmentId":51594469,"attachmentType":"pdf","work_url":"https://www.academia.edu/31163849/Isotachophoresis_at_pH_extremes_Theory_and_experimental_validation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" 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class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="46232650" href="https://independent.academia.edu/TakeshiHirokawa">Takeshi Hirokawa</a></div><p class="ds-related-work--metadata ds2-5-body-xs">ELECTROPHORESIS, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Impact of reservoir potentials on the analyte behavior in microchip electrophoresis: Computer simulation and experimental validation for DNA fragments","attachmentId":44377940,"attachmentType":"pdf","work_url":"https://www.academia.edu/23987668/Impact_of_reservoir_potentials_on_the_analyte_behavior_in_microchip_electrophoresis_Computer_simulation_and_experimental_validation_for_DNA_fragments","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span 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