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src="https://0.academia-photos.com/3323325/1785850/8416256/s200_h_seyin._zg_rd_.jpg" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Dr. H眉seyin 陌zg枚rd眉</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://xn--esog-3ra.academia.edu/">Eski艧ehir Osmangazi 眉niversitesi</a>, <a class="u-tcGrayDarker" href="https://xn--esog-3ra.academia.edu/Departments/Akci%C4%9Fer_ve_Plevra_Kanserleri_Uygulama_ve_Ara%C5%9Ft%C4%B1rma_Merkezi/Documents">Akci臒er ve Plevra Kanserleri Uygulama ve Ara艧t谋rma Merkezi</a>, <span class="u-tcGrayDarker">Post-Doc</span></div><div><a class="u-tcGrayDarker" href="https://eskisehir.academia.edu/">Eskisehir Technical University</a>, <a class="u-tcGrayDarker" href="https://eskisehir.academia.edu/Departments/Fen_Fak%C3%BCltesi/Documents">Fen Fak眉ltesi</a>, <span class="u-tcGrayDarker">Graduate Student</span></div></div></div></div><div class="sidebar-cta-container"><button 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u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="3323325" href="https://www.academia.edu/Documents/in/Molecular_Biology"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://xn--esog-3ra.academia.edu/DrH%C3%BCseyin%C4%B0zg%C3%B6rd%C3%BC","location":"/DrH%C3%BCseyin%C4%B0zg%C3%B6rd%C3%BC","scheme":"https","host":"xn--esog-3ra.academia.edu","port":null,"pathname":"/DrH%C3%BCseyin%C4%B0zg%C3%B6rd%C3%BC","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Molecular Biology"]}" data-trace="false" 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class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Dr. H眉seyin 陌zg枚rd眉</h3></div><div class="js-work-strip profile--work_container" data-work-id="125651707"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/125651707/Pdf_MPJ"><img alt="Research paper thumbnail of Pdf MPJ" class="work-thumbnail" src="https://attachments.academia-assets.com/119655874/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125651707/Pdf_MPJ">Pdf MPJ</a></div><div class="wp-workCard_item 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78944889"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78944889/Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells"><img alt="Research paper thumbnail of Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78944889/Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells">Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells</a></div><div class="wp-workCard_item"><span>Bilecik 艦eyh Edebali 脺niversitesi Fen Bilimleri Dergisi</span><span>, Sep 30, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Sfingolipidler, bircok kanserde hucre olumu, hayatta kalma ve ilac direnci gibi biyolojik islemle...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Sfingolipidler, bircok kanserde hucre olumu, hayatta kalma ve ilac direnci gibi biyolojik islemlerde kritik rol oynamaktadir. Seramid ve dihidroseramid, proliferasyon ve olume bagli olan sfingolipidlerdir. Son kanser arastirmalari, kanser-sfingolipid metabolizmasinin netlestirilmesine odaklanmistir. Son yillarda, sfingolipid metabolizmasi iliskisinde kilit bir molekul olarak seramid, antikanser aktivitesi icin seramidaz inhibitor uygulamasi ile hucre ici seviyesini arttirarak arastirilmistir. Prostat kanseri, en sik gorulen insan kanserleri arasindadir ve kansere bagli en yaygin ikinci olum nedeni olarak rapor edilmektedir. Prostat kanseri, 65 yasindan buyuklerde yaygindir. Bu calismanin amaci, bir seramidaz inhibitoru olan聽 (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol鈥檜n (D-eritro-MAPP) insan prostat kanseri DU-145 hucreleri uzerindeki potansiyel sitotoksik aktivitesini MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) testi, akis sitometrisi, konfokal ve TEM mikroskopisi kullanarak arastirmaktir. MTT bulgulari D-eritro-MAPP&#39;nin DU-145 hucrelerinde dusuk dozlarda toksisiteye neden oldugunu gostermistir. Konfokal ve TEM mikroskopi bulgulari, hucre iskeletinde delik olusumunu, kromatin yogunlasmasini, morfolojik degisiklikler olarak at nali seklindeki hucre cekirdeklerini ve hucre zari uzerindeki tomurcuklanmalari, cekirdeklerin parcalanmasini, kromatin yogunlasmasini ve ultra yapisal degisiklikler olarak krista kaybini gostermistir. Akis sitometrisi bulgulari, D-eritro-MAPP&#39;in DU-145 hucrelerine 24 saatlik kisa sureli uygulamasinda apoptozu tetikledigini gostermistir. Elde edilen sonuclara gore, D-eritro-MAPP&#39;in DU-145 hucrelerinin canliligini doza bagli bir sekilde azalttigi soylenebilir. Bulgularimiz, D-eritro-MAPP&#39;in DU-145 hucreleri uzerindeki anti-kanser ve sitotoksik potansiyelini ortaya koymustur ve bu ajanin, in vitro ve in vivo calismalardan sonra kanser tedavisi icin ilac gelistirmede kullanilabilecegi belirtilmistir.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78944889"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78944889"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78944889; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78944889]").text(description); $(".js-view-count[data-work-id=78944889]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78944889; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78944889']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78944889, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=78944889]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78944889,"title":"Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells","translated_title":"","metadata":{"abstract":"Sfingolipidler, bircok kanserde hucre olumu, hayatta kalma ve ilac direnci gibi biyolojik islemlerde kritik rol oynamaktadir. Seramid ve dihidroseramid, proliferasyon ve olume bagli olan sfingolipidlerdir. Son kanser arastirmalari, kanser-sfingolipid metabolizmasinin netlestirilmesine odaklanmistir. Son yillarda, sfingolipid metabolizmasi iliskisinde kilit bir molekul olarak seramid, antikanser aktivitesi icin seramidaz inhibitor uygulamasi ile hucre ici seviyesini arttirarak arastirilmistir. Prostat kanseri, en sik gorulen insan kanserleri arasindadir ve kansere bagli en yaygin ikinci olum nedeni olarak rapor edilmektedir. Prostat kanseri, 65 yasindan buyuklerde yaygindir. Bu calismanin amaci, bir seramidaz inhibitoru olan聽 (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol鈥檜n (D-eritro-MAPP) insan prostat kanseri DU-145 hucreleri uzerindeki potansiyel sitotoksik aktivitesini MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) testi, akis sitometrisi, konfokal ve TEM mikroskopisi kullanarak arastirmaktir. MTT bulgulari D-eritro-MAPP\u0026#39;nin DU-145 hucrelerinde dusuk dozlarda toksisiteye neden oldugunu gostermistir. Konfokal ve TEM mikroskopi bulgulari, hucre iskeletinde delik olusumunu, kromatin yogunlasmasini, morfolojik degisiklikler olarak at nali seklindeki hucre cekirdeklerini ve hucre zari uzerindeki tomurcuklanmalari, cekirdeklerin parcalanmasini, kromatin yogunlasmasini ve ultra yapisal degisiklikler olarak krista kaybini gostermistir. Akis sitometrisi bulgulari, D-eritro-MAPP\u0026#39;in DU-145 hucrelerine 24 saatlik kisa sureli uygulamasinda apoptozu tetikledigini gostermistir. Elde edilen sonuclara gore, D-eritro-MAPP\u0026#39;in DU-145 hucrelerinin canliligini doza bagli bir sekilde azalttigi soylenebilir. Bulgularimiz, D-eritro-MAPP\u0026#39;in DU-145 hucreleri uzerindeki anti-kanser ve sitotoksik potansiyelini ortaya koymustur ve bu ajanin, in vitro ve in vivo calismalardan sonra kanser tedavisi icin ilac gelistirmede kullanilabilecegi belirtilmistir.","publication_date":{"day":30,"month":9,"year":2019,"errors":{}},"publication_name":"Bilecik 艦eyh Edebali 脺niversitesi Fen Bilimleri Dergisi"},"translated_abstract":"Sfingolipidler, bircok kanserde hucre olumu, hayatta kalma ve ilac direnci gibi biyolojik islemlerde kritik rol oynamaktadir. Seramid ve dihidroseramid, proliferasyon ve olume bagli olan sfingolipidlerdir. Son kanser arastirmalari, kanser-sfingolipid metabolizmasinin netlestirilmesine odaklanmistir. Son yillarda, sfingolipid metabolizmasi iliskisinde kilit bir molekul olarak seramid, antikanser aktivitesi icin seramidaz inhibitor uygulamasi ile hucre ici seviyesini arttirarak arastirilmistir. Prostat kanseri, en sik gorulen insan kanserleri arasindadir ve kansere bagli en yaygin ikinci olum nedeni olarak rapor edilmektedir. Prostat kanseri, 65 yasindan buyuklerde yaygindir. Bu calismanin amaci, bir seramidaz inhibitoru olan聽 (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol鈥檜n (D-eritro-MAPP) insan prostat kanseri DU-145 hucreleri uzerindeki potansiyel sitotoksik aktivitesini MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) testi, akis sitometrisi, konfokal ve TEM mikroskopisi kullanarak arastirmaktir. MTT bulgulari D-eritro-MAPP\u0026#39;nin DU-145 hucrelerinde dusuk dozlarda toksisiteye neden oldugunu gostermistir. Konfokal ve TEM mikroskopi bulgulari, hucre iskeletinde delik olusumunu, kromatin yogunlasmasini, morfolojik degisiklikler olarak at nali seklindeki hucre cekirdeklerini ve hucre zari uzerindeki tomurcuklanmalari, cekirdeklerin parcalanmasini, kromatin yogunlasmasini ve ultra yapisal degisiklikler olarak krista kaybini gostermistir. Akis sitometrisi bulgulari, D-eritro-MAPP\u0026#39;in DU-145 hucrelerine 24 saatlik kisa sureli uygulamasinda apoptozu tetikledigini gostermistir. Elde edilen sonuclara gore, D-eritro-MAPP\u0026#39;in DU-145 hucrelerinin canliligini doza bagli bir sekilde azalttigi soylenebilir. Bulgularimiz, D-eritro-MAPP\u0026#39;in DU-145 hucreleri uzerindeki anti-kanser ve sitotoksik potansiyelini ortaya koymustur ve bu ajanin, in vitro ve in vivo calismalardan sonra kanser tedavisi icin ilac gelistirmede kullanilabilecegi belirtilmistir.","internal_url":"https://www.academia.edu/78944889/Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells","translated_internal_url":"","created_at":"2022-05-10T14:18:32.475-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3323325,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41822258,"work_id":78944889,"tagging_user_id":3323325,"tagged_user_id":10456834,"co_author_invite_id":null,"email":"h***u@anadolu.edu.tr","display_order":0,"name":"Hatice Kutlu","title":"Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells"},{"id":42706788,"work_id":78944889,"tagging_user_id":3323325,"tagged_user_id":109855918,"co_author_invite_id":null,"email":"h***u@eskisehir.edu.tr","affiliation":"Eskisehir Anadolu Univeristesi","display_order":1073741824,"name":"Mehtap Kutlu","title":"Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells"}],"downloadable_attachments":[],"slug":"Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells","translated_slug":"","page_count":null,"language":"tr","content_type":"Work","owner":{"id":3323325,"first_name":"Dr. H眉seyin","middle_initials":null,"last_name":"陌zg枚rd眉","page_name":"DrH眉seyin陌zg枚rd眉","domain_name":"xn--esog-3ra","created_at":"2013-02-12T17:05:33.621-08:00","display_name":"Dr. H眉seyin 陌zg枚rd眉","url":"https://xn--esog-3ra.academia.edu/DrH%C3%BCseyin%C4%B0zg%C3%B6rd%C3%BC"},"attachments":[],"research_interests":[{"id":12980,"name":"Prostate Cancer","url":"https://www.academia.edu/Documents/in/Prostate_Cancer"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"}],"urls":[{"id":20393252,"url":"https://app.trdizin.gov.tr/publication/paper/detail/TXpFM05UUTNOdz09"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="70651009"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70651009/I_nsan_Prostat_Kanseri_Hu_crelerinde_D_e_MAPP_kaynakl%C4%B1_Sitotoksisitenin_Aras_t%C4%B1r%C4%B1lmas%C4%B1_Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells"><img alt="Research paper thumbnail of I虈nsan Prostat Kanseri Hu虉crelerinde D-e-MAPP kaynakl谋 Sitotoksisitenin Aras抬t谋r谋lmas谋 Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/80313601/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70651009/I_nsan_Prostat_Kanseri_Hu_crelerinde_D_e_MAPP_kaynakl%C4%B1_Sitotoksisitenin_Aras_t%C4%B1r%C4%B1lmas%C4%B1_Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells">I虈nsan Prostat Kanseri Hu虉crelerinde D-e-MAPP kaynakl谋 Sitotoksisitenin Aras抬t谋r谋lmas谋 Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">zSfingolipidler, bir莽ok kanserde h眉cre 枚l眉m眉, hayatta kalma ve ila莽 direnci gibi biyolojik i艧leml...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">zSfingolipidler, bir莽ok kanserde h眉cre 枚l眉m眉, hayatta kalma ve ila莽 direnci gibi biyolojik i艧lemlerde kritik rol oynamaktad谋r. Seramid ve dihidroseramid, proliferasyon ve 枚l眉me ba臒l谋 olan sfingolipidlerdir. Son kanser ara艧t谋rmalar谋, kanser-sfingolipid metabolizmas谋n谋n netle艧tirilmesine odaklanm谋艧t谋r. Son y谋llarda, sfingolipid metabolizmas谋 ili艧kisinde kilit bir molek眉l olarak seramid, antikanser aktivitesi i莽in seramidaz inhibit枚r uygulamas谋 ile h眉cre i莽i seviyesini artt谋rarak ara艧t谋r谋lm谋艧t谋r. Prostat kanseri, en s谋k g枚r眉len insan kanserleri aras谋ndad谋r ve kansere ba臒l谋 en yayg谋n ikinci 枚l眉m nedeni olarak rapor edilmektedir. Prostat kanseri, 65 ya艧谋ndan b眉y眉klerde yayg谋nd谋r. Bu 莽al谋艧man谋n amac谋, bir seramidaz inhibit枚r眉 olan (1S,2R)-D-erythro-2-(N-Myristoylamino)1-phenyl-1-propanol鈥檜n (D-eritro-MAPP) insan prostat kanseri DU-145 h眉creleri 眉zerindeki potansiyel sitotoksik aktivitesini MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) testi, ak谋艧 sitometrisi, konfokal...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f50946073a0cbc965d65134875ad6024" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":80313601,"asset_id":70651009,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/80313601/download_file?st=MTczMjcwMTI0MCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70651009"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70651009"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70651009; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70651009]").text(description); $(".js-view-count[data-work-id=70651009]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70651009; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70651009']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70651009, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f50946073a0cbc965d65134875ad6024" } } $('.js-work-strip[data-work-id=70651009]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70651009,"title":"I虈nsan Prostat Kanseri Hu虉crelerinde D-e-MAPP kaynakl谋 Sitotoksisitenin Aras抬t谋r谋lmas谋 Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells","translated_title":"","metadata":{"abstract":"zSfingolipidler, bir莽ok kanserde h眉cre 枚l眉m眉, hayatta kalma ve ila莽 direnci gibi biyolojik i艧lemlerde kritik rol oynamaktad谋r. Seramid ve dihidroseramid, proliferasyon ve 枚l眉me ba臒l谋 olan sfingolipidlerdir. Son kanser ara艧t谋rmalar谋, kanser-sfingolipid metabolizmas谋n谋n netle艧tirilmesine odaklanm谋艧t谋r. Son y谋llarda, sfingolipid metabolizmas谋 ili艧kisinde kilit bir molek眉l olarak seramid, antikanser aktivitesi i莽in seramidaz inhibit枚r uygulamas谋 ile h眉cre i莽i seviyesini artt谋rarak ara艧t谋r谋lm谋艧t谋r. Prostat kanseri, en s谋k g枚r眉len insan kanserleri aras谋ndad谋r ve kansere ba臒l谋 en yayg谋n ikinci 枚l眉m nedeni olarak rapor edilmektedir. Prostat kanseri, 65 ya艧谋ndan b眉y眉klerde yayg谋nd谋r. Bu 莽al谋艧man谋n amac谋, bir seramidaz inhibit枚r眉 olan (1S,2R)-D-erythro-2-(N-Myristoylamino)1-phenyl-1-propanol鈥檜n (D-eritro-MAPP) insan prostat kanseri DU-145 h眉creleri 眉zerindeki potansiyel sitotoksik aktivitesini MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) testi, ak谋艧 sitometrisi, konfokal...","publication_date":{"day":null,"month":null,"year":2019,"errors":{}}},"translated_abstract":"zSfingolipidler, bir莽ok kanserde h眉cre 枚l眉m眉, hayatta kalma ve ila莽 direnci gibi biyolojik i艧lemlerde kritik rol oynamaktad谋r. Seramid ve dihidroseramid, proliferasyon ve 枚l眉me ba臒l谋 olan sfingolipidlerdir. Son kanser ara艧t谋rmalar谋, kanser-sfingolipid metabolizmas谋n谋n netle艧tirilmesine odaklanm谋艧t谋r. Son y谋llarda, sfingolipid metabolizmas谋 ili艧kisinde kilit bir molek眉l olarak seramid, antikanser aktivitesi i莽in seramidaz inhibit枚r uygulamas谋 ile h眉cre i莽i seviyesini artt谋rarak ara艧t谋r谋lm谋艧t谋r. Prostat kanseri, en s谋k g枚r眉len insan kanserleri aras谋ndad谋r ve kansere ba臒l谋 en yayg谋n ikinci 枚l眉m nedeni olarak rapor edilmektedir. Prostat kanseri, 65 ya艧谋ndan b眉y眉klerde yayg谋nd谋r. Bu 莽al谋艧man谋n amac谋, bir seramidaz inhibit枚r眉 olan (1S,2R)-D-erythro-2-(N-Myristoylamino)1-phenyl-1-propanol鈥檜n (D-eritro-MAPP) insan prostat kanseri DU-145 h眉creleri 眉zerindeki potansiyel sitotoksik aktivitesini MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) testi, ak谋艧 sitometrisi, konfokal...","internal_url":"https://www.academia.edu/70651009/I_nsan_Prostat_Kanseri_Hu_crelerinde_D_e_MAPP_kaynakl%C4%B1_Sitotoksisitenin_Aras_t%C4%B1r%C4%B1lmas%C4%B1_Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells","translated_internal_url":"","created_at":"2022-02-06T00:13:59.151-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3323325,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":37655050,"work_id":70651009,"tagging_user_id":3323325,"tagged_user_id":109855918,"co_author_invite_id":null,"email":"h***u@eskisehir.edu.tr","affiliation":"Eskisehir Anadolu 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="64673553"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/64673553/Bursa_Aphodiinae_ve_Scarabaeinae_Coleoptera_Scarabaeidae_T%C3%BCrleri_%C3%9Czerine_Faunistik_Bir_%C3%87al%C4%B1%C5%9Fma"><img alt="Research paper thumbnail of Bursa Aphodiinae ve Scarabaeinae (Coleoptera: Scarabaeidae) T眉rleri 脺zerine Faunistik Bir 脟al谋艧ma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/64673553/Bursa_Aphodiinae_ve_Scarabaeinae_Coleoptera_Scarabaeidae_T%C3%BCrleri_%C3%9Czerine_Faunistik_Bir_%C3%87al%C4%B1%C5%9Fma">Bursa Aphodiinae ve Scarabaeinae (Coleoptera: Scarabaeidae) T眉rleri 脺zerine Faunistik Bir 脟al谋艧ma</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://xn--esog-3ra.academia.edu/DrH%C3%BCseyin%C4%B0zg%C3%B6rd%C3%BC">Dr. H眉seyin 陌zg枚rd眉</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MehmetG%C3%9CLMEZ1">Mehmet G脺LMEZ</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bu calisma 2006-2007 yillarinda Bursa cevresinde Aphodiinae ve Scarabaeinae turleri uzerine聽 yapi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bu calisma 2006-2007 yillarinda Bursa cevresinde Aphodiinae ve Scarabaeinae turleri uzerine聽 yapilmistir. Bu calismada 8 cinse ait 29 tur bulunmustur. Bulunan her bir turun Turkiye`deki ve Palearktik bolgedeki yayilislari verilmistir. Onthophagus (Amphionthophagus) falzonii Goidanich, 1926, O. (Onthophagus) illyricus (Scopoli, 1763), O. (Palaeonthophagus) coenobita (Herbst, 1783), O. lucidus (Sturm 1800), O. osellai Pittino, 1982, O. similis (Scriba, 1790), O. (Paleonthophagus) medius (Kugelann, 1792) turleri Marmara Bolgesi icin yeni kayittir. Aphodius (Acrossus) luridus (Fabricius, 1775), A. (Calamosternus) granarius (Linnaeus, 1767), A. (Eudolus) quadriguttatus (Herbst, 1783), A. (Melinopterus) prodromus (Brahm, 1790), A. punctatosulcatus (Sturm, 1805), O. (Palaeonthophagus) verticicornis (Laicharting, 1781) turleri Marmara Bolgesinin Anadolu Yakasi icin yeni kayittir.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="64673553"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="64673553"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 64673553; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=64673553]").text(description); $(".js-view-count[data-work-id=64673553]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 64673553; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='64673553']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 64673553, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=64673553]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":64673553,"title":"Bursa Aphodiinae ve Scarabaeinae (Coleoptera: Scarabaeidae) T眉rleri 脺zerine Faunistik Bir 脟al谋艧ma","translated_title":"","metadata":{"abstract":"Bu calisma 2006-2007 yillarinda Bursa cevresinde Aphodiinae ve Scarabaeinae turleri uzerine聽 yapilmistir. Bu calismada 8 cinse ait 29 tur bulunmustur. Bulunan her bir turun Turkiye`deki ve Palearktik bolgedeki yayilislari verilmistir. Onthophagus (Amphionthophagus) falzonii Goidanich, 1926, O. (Onthophagus) illyricus (Scopoli, 1763), O. (Palaeonthophagus) coenobita (Herbst, 1783), O. lucidus (Sturm 1800), O. osellai Pittino, 1982, O. similis (Scriba, 1790), O. (Paleonthophagus) medius (Kugelann, 1792) turleri Marmara Bolgesi icin yeni kayittir. Aphodius (Acrossus) luridus (Fabricius, 1775), A. (Calamosternus) granarius (Linnaeus, 1767), A. (Eudolus) quadriguttatus (Herbst, 1783), A. (Melinopterus) prodromus (Brahm, 1790), A. punctatosulcatus (Sturm, 1805), O. (Palaeonthophagus) verticicornis (Laicharting, 1781) turleri Marmara Bolgesinin Anadolu Yakasi icin yeni kayittir.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}}},"translated_abstract":"Bu calisma 2006-2007 yillarinda Bursa cevresinde Aphodiinae ve Scarabaeinae turleri uzerine聽 yapilmistir. 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Bu calismanin amac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bu calisma 2011 ve 2013 yillarinda 艦anliurfa鈥檔in Horzum Koyunde yurutulmustur. Bu calismanin amaci Horzum koyu bokbocegi faunasini belirlemektir. Sonuc olarak Scarabaeinae ve Aphodiinae altfamilyalari 5 cinse bagli 9 tur icermektedir. Tespit edilen butun turler calisma alani icin yeni kayitlardir. Butun turlerin Turkiye ve Palearktik yayilislari belirlenmistir.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="64673551"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="64673551"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 64673551; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=64673551]").text(description); $(".js-view-count[data-work-id=64673551]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 64673551; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='64673551']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 64673551, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=64673551]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":64673551,"title":"A Preliminary Study on the Fauna of Dung Beetle (Scarabaeidae, Coleoptera) at Horzum Village of 艦anliurfa","translated_title":"","metadata":{"abstract":"Bu calisma 2011 ve 2013 yillarinda 艦anliurfa鈥檔in Horzum Koyunde yurutulmustur. 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Bone cancer is a type of prevalent cancer that occurs both in youngsters and adults. Bone cancer is mostly common in the long bones of the pelvis, arms, and legs. Statistically, more than 200 cases of osteosarcoma have been reported annually in our country. Classical treatment with chemotherapeutics remains ineffective for the cure of this cancer. Recent studies have shown that ceramide induces apoptosis due to its increased levels in the cells. Thus, many studies have been conducted for the accumulation of ceramide molecules in the cell by different ways to induce apoptosis. NOE (N-oleoylethanolamine) is a specific inhibitor of ceramidase enzymes that hydrolyse intracellular ceramides and prevent apoptosis. OBJECTIVE This study investigates the cytotoxic and apoptosis-inducing activities of NOE on human osteosarcoma Saos-2 cells. METHODS Cytotoxic effects were investigated by MTT co...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="64673549"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="64673549"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 64673549; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=64673549]").text(description); $(".js-view-count[data-work-id=64673549]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 64673549; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='64673549']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 64673549, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=64673549]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":64673549,"title":"Cytotoxic Impacts of N-Oleoylethanolamine in Bone Cancer Cells","translated_title":"","metadata":{"abstract":"BACKGROUND Cancer is a complex disease that is derived from the uncontrolled proliferation of cells. 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Bu calismanin amac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bu calisma 2011 ve 2013 yillarinda 艦anliurfa鈥檔in Horzum Koyunde yurutulmustur. Bu calismanin amaci Horzum koyu bokbocegi faunasini belirlemektir. Sonuc olarak Scarabaeinae ve Aphodiinae altfamilyalari 5 cinse bagli 9 tur icermektedir. Tespit edilen butun turler calisma alani icin yeni kayitlardir. 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Bitkilerde do臒al olarak bulunan polifenollerin antioksidan 枚zellikleri bilinmektedir. Polifenoller biyolojik aktiviteleri, besinsel ve antioksidan de臒erleri sebebiyle ara艧t谋rmalarda yer alm谋艧t谋r. Ellajik asit 莽ilek, k谋z谋lc谋k, ceviz, nar ve ahududu gibi bir莽ok meyvede bulunan do臒al bir bile艧iktir. Ellajik asit antioksidan 枚zellikleri ile bilinen ve insan v眉cudunu zararl谋 serbest radikallerden koruyan bir bile艧iktir. Bu 莽al谋艧mada ellajik asit bir莽ok kanser h眉cresi 眉zerinde h眉cre b眉y眉mesini bask谋lama 枚zelli臒inden dolay谋 akci臒er kanseri A549 h眉crelerinde h眉cre 枚l眉m眉n眉 tetiklemek amac谋yla kullan谋lm谋艧t谋r. A549 h眉crelerine ellajik asidin sitotoksik etkilerini ara艧t谋rmak i莽in MTT (3-(4,5dimethylthiazol-2-yl)-2,5 diphenyl-2H-tetrazolium bromide) tekni臒i kullan谋lm谋艧t谋r. Buna ilaveten ince yap谋sal ve morfolojik de臒i艧iklikler TEM ve konfokal mikroskopi teknikleri kullan谋larak de臒erlendirilmi艧tir. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78944889"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78944889/Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells"><img alt="Research paper thumbnail of Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78944889/Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells">Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells</a></div><div class="wp-workCard_item"><span>Bilecik 艦eyh Edebali 脺niversitesi Fen Bilimleri Dergisi</span><span>, Sep 30, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Sfingolipidler, bircok kanserde hucre olumu, hayatta kalma ve ilac direnci gibi biyolojik islemle...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Sfingolipidler, bircok kanserde hucre olumu, hayatta kalma ve ilac direnci gibi biyolojik islemlerde kritik rol oynamaktadir. Seramid ve dihidroseramid, proliferasyon ve olume bagli olan sfingolipidlerdir. Son kanser arastirmalari, kanser-sfingolipid metabolizmasinin netlestirilmesine odaklanmistir. Son yillarda, sfingolipid metabolizmasi iliskisinde kilit bir molekul olarak seramid, antikanser aktivitesi icin seramidaz inhibitor uygulamasi ile hucre ici seviyesini arttirarak arastirilmistir. Prostat kanseri, en sik gorulen insan kanserleri arasindadir ve kansere bagli en yaygin ikinci olum nedeni olarak rapor edilmektedir. Prostat kanseri, 65 yasindan buyuklerde yaygindir. Bu calismanin amaci, bir seramidaz inhibitoru olan聽 (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol鈥檜n (D-eritro-MAPP) insan prostat kanseri DU-145 hucreleri uzerindeki potansiyel sitotoksik aktivitesini MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) testi, akis sitometrisi, konfokal ve TEM mikroskopisi kullanarak arastirmaktir. MTT bulgulari D-eritro-MAPP&#39;nin DU-145 hucrelerinde dusuk dozlarda toksisiteye neden oldugunu gostermistir. Konfokal ve TEM mikroskopi bulgulari, hucre iskeletinde delik olusumunu, kromatin yogunlasmasini, morfolojik degisiklikler olarak at nali seklindeki hucre cekirdeklerini ve hucre zari uzerindeki tomurcuklanmalari, cekirdeklerin parcalanmasini, kromatin yogunlasmasini ve ultra yapisal degisiklikler olarak krista kaybini gostermistir. Akis sitometrisi bulgulari, D-eritro-MAPP&#39;in DU-145 hucrelerine 24 saatlik kisa sureli uygulamasinda apoptozu tetikledigini gostermistir. Elde edilen sonuclara gore, D-eritro-MAPP&#39;in DU-145 hucrelerinin canliligini doza bagli bir sekilde azalttigi soylenebilir. Bulgularimiz, D-eritro-MAPP&#39;in DU-145 hucreleri uzerindeki anti-kanser ve sitotoksik potansiyelini ortaya koymustur ve bu ajanin, in vitro ve in vivo calismalardan sonra kanser tedavisi icin ilac gelistirmede kullanilabilecegi belirtilmistir.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78944889"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78944889"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78944889; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78944889]").text(description); $(".js-view-count[data-work-id=78944889]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78944889; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78944889']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78944889, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=78944889]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78944889,"title":"Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells","translated_title":"","metadata":{"abstract":"Sfingolipidler, bircok kanserde hucre olumu, hayatta kalma ve ilac direnci gibi biyolojik islemlerde kritik rol oynamaktadir. Seramid ve dihidroseramid, proliferasyon ve olume bagli olan sfingolipidlerdir. Son kanser arastirmalari, kanser-sfingolipid metabolizmasinin netlestirilmesine odaklanmistir. Son yillarda, sfingolipid metabolizmasi iliskisinde kilit bir molekul olarak seramid, antikanser aktivitesi icin seramidaz inhibitor uygulamasi ile hucre ici seviyesini arttirarak arastirilmistir. Prostat kanseri, en sik gorulen insan kanserleri arasindadir ve kansere bagli en yaygin ikinci olum nedeni olarak rapor edilmektedir. Prostat kanseri, 65 yasindan buyuklerde yaygindir. Bu calismanin amaci, bir seramidaz inhibitoru olan聽 (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol鈥檜n (D-eritro-MAPP) insan prostat kanseri DU-145 hucreleri uzerindeki potansiyel sitotoksik aktivitesini MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) testi, akis sitometrisi, konfokal ve TEM mikroskopisi kullanarak arastirmaktir. MTT bulgulari D-eritro-MAPP\u0026#39;nin DU-145 hucrelerinde dusuk dozlarda toksisiteye neden oldugunu gostermistir. Konfokal ve TEM mikroskopi bulgulari, hucre iskeletinde delik olusumunu, kromatin yogunlasmasini, morfolojik degisiklikler olarak at nali seklindeki hucre cekirdeklerini ve hucre zari uzerindeki tomurcuklanmalari, cekirdeklerin parcalanmasini, kromatin yogunlasmasini ve ultra yapisal degisiklikler olarak krista kaybini gostermistir. Akis sitometrisi bulgulari, D-eritro-MAPP\u0026#39;in DU-145 hucrelerine 24 saatlik kisa sureli uygulamasinda apoptozu tetikledigini gostermistir. Elde edilen sonuclara gore, D-eritro-MAPP\u0026#39;in DU-145 hucrelerinin canliligini doza bagli bir sekilde azalttigi soylenebilir. Bulgularimiz, D-eritro-MAPP\u0026#39;in DU-145 hucreleri uzerindeki anti-kanser ve sitotoksik potansiyelini ortaya koymustur ve bu ajanin, in vitro ve in vivo calismalardan sonra kanser tedavisi icin ilac gelistirmede kullanilabilecegi belirtilmistir.","publication_date":{"day":30,"month":9,"year":2019,"errors":{}},"publication_name":"Bilecik 艦eyh Edebali 脺niversitesi Fen Bilimleri Dergisi"},"translated_abstract":"Sfingolipidler, bircok kanserde hucre olumu, hayatta kalma ve ilac direnci gibi biyolojik islemlerde kritik rol oynamaktadir. Seramid ve dihidroseramid, proliferasyon ve olume bagli olan sfingolipidlerdir. Son kanser arastirmalari, kanser-sfingolipid metabolizmasinin netlestirilmesine odaklanmistir. Son yillarda, sfingolipid metabolizmasi iliskisinde kilit bir molekul olarak seramid, antikanser aktivitesi icin seramidaz inhibitor uygulamasi ile hucre ici seviyesini arttirarak arastirilmistir. Prostat kanseri, en sik gorulen insan kanserleri arasindadir ve kansere bagli en yaygin ikinci olum nedeni olarak rapor edilmektedir. Prostat kanseri, 65 yasindan buyuklerde yaygindir. Bu calismanin amaci, bir seramidaz inhibitoru olan聽 (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol鈥檜n (D-eritro-MAPP) insan prostat kanseri DU-145 hucreleri uzerindeki potansiyel sitotoksik aktivitesini MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) testi, akis sitometrisi, konfokal ve TEM mikroskopisi kullanarak arastirmaktir. MTT bulgulari D-eritro-MAPP\u0026#39;nin DU-145 hucrelerinde dusuk dozlarda toksisiteye neden oldugunu gostermistir. Konfokal ve TEM mikroskopi bulgulari, hucre iskeletinde delik olusumunu, kromatin yogunlasmasini, morfolojik degisiklikler olarak at nali seklindeki hucre cekirdeklerini ve hucre zari uzerindeki tomurcuklanmalari, cekirdeklerin parcalanmasini, kromatin yogunlasmasini ve ultra yapisal degisiklikler olarak krista kaybini gostermistir. Akis sitometrisi bulgulari, D-eritro-MAPP\u0026#39;in DU-145 hucrelerine 24 saatlik kisa sureli uygulamasinda apoptozu tetikledigini gostermistir. Elde edilen sonuclara gore, D-eritro-MAPP\u0026#39;in DU-145 hucrelerinin canliligini doza bagli bir sekilde azalttigi soylenebilir. Bulgularimiz, D-eritro-MAPP\u0026#39;in DU-145 hucreleri uzerindeki anti-kanser ve sitotoksik potansiyelini ortaya koymustur ve bu ajanin, in vitro ve in vivo calismalardan sonra kanser tedavisi icin ilac gelistirmede kullanilabilecegi belirtilmistir.","internal_url":"https://www.academia.edu/78944889/Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells","translated_internal_url":"","created_at":"2022-05-10T14:18:32.475-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3323325,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41822258,"work_id":78944889,"tagging_user_id":3323325,"tagged_user_id":10456834,"co_author_invite_id":null,"email":"h***u@anadolu.edu.tr","display_order":0,"name":"Hatice Kutlu","title":"Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells"},{"id":42706788,"work_id":78944889,"tagging_user_id":3323325,"tagged_user_id":109855918,"co_author_invite_id":null,"email":"h***u@eskisehir.edu.tr","affiliation":"Eskisehir Anadolu Univeristesi","display_order":1073741824,"name":"Mehtap Kutlu","title":"Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells"}],"downloadable_attachments":[],"slug":"Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells","translated_slug":"","page_count":null,"language":"tr","content_type":"Work","owner":{"id":3323325,"first_name":"Dr. H眉seyin","middle_initials":null,"last_name":"陌zg枚rd眉","page_name":"DrH眉seyin陌zg枚rd眉","domain_name":"xn--esog-3ra","created_at":"2013-02-12T17:05:33.621-08:00","display_name":"Dr. H眉seyin 陌zg枚rd眉","url":"https://xn--esog-3ra.academia.edu/DrH%C3%BCseyin%C4%B0zg%C3%B6rd%C3%BC"},"attachments":[],"research_interests":[{"id":12980,"name":"Prostate Cancer","url":"https://www.academia.edu/Documents/in/Prostate_Cancer"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"}],"urls":[{"id":20393252,"url":"https://app.trdizin.gov.tr/publication/paper/detail/TXpFM05UUTNOdz09"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="70651009"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/70651009/I_nsan_Prostat_Kanseri_Hu_crelerinde_D_e_MAPP_kaynakl%C4%B1_Sitotoksisitenin_Aras_t%C4%B1r%C4%B1lmas%C4%B1_Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells"><img alt="Research paper thumbnail of I虈nsan Prostat Kanseri Hu虉crelerinde D-e-MAPP kaynakl谋 Sitotoksisitenin Aras抬t谋r谋lmas谋 Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/80313601/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/70651009/I_nsan_Prostat_Kanseri_Hu_crelerinde_D_e_MAPP_kaynakl%C4%B1_Sitotoksisitenin_Aras_t%C4%B1r%C4%B1lmas%C4%B1_Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells">I虈nsan Prostat Kanseri Hu虉crelerinde D-e-MAPP kaynakl谋 Sitotoksisitenin Aras抬t谋r谋lmas谋 Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">zSfingolipidler, bir莽ok kanserde h眉cre 枚l眉m眉, hayatta kalma ve ila莽 direnci gibi biyolojik i艧leml...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">zSfingolipidler, bir莽ok kanserde h眉cre 枚l眉m眉, hayatta kalma ve ila莽 direnci gibi biyolojik i艧lemlerde kritik rol oynamaktad谋r. Seramid ve dihidroseramid, proliferasyon ve 枚l眉me ba臒l谋 olan sfingolipidlerdir. Son kanser ara艧t谋rmalar谋, kanser-sfingolipid metabolizmas谋n谋n netle艧tirilmesine odaklanm谋艧t谋r. Son y谋llarda, sfingolipid metabolizmas谋 ili艧kisinde kilit bir molek眉l olarak seramid, antikanser aktivitesi i莽in seramidaz inhibit枚r uygulamas谋 ile h眉cre i莽i seviyesini artt谋rarak ara艧t谋r谋lm谋艧t谋r. Prostat kanseri, en s谋k g枚r眉len insan kanserleri aras谋ndad谋r ve kansere ba臒l谋 en yayg谋n ikinci 枚l眉m nedeni olarak rapor edilmektedir. Prostat kanseri, 65 ya艧谋ndan b眉y眉klerde yayg谋nd谋r. Bu 莽al谋艧man谋n amac谋, bir seramidaz inhibit枚r眉 olan (1S,2R)-D-erythro-2-(N-Myristoylamino)1-phenyl-1-propanol鈥檜n (D-eritro-MAPP) insan prostat kanseri DU-145 h眉creleri 眉zerindeki potansiyel sitotoksik aktivitesini MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) testi, ak谋艧 sitometrisi, konfokal...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f50946073a0cbc965d65134875ad6024" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":80313601,"asset_id":70651009,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/80313601/download_file?st=MTczMjcwMTI0MSw4LjIyMi4yMDguMTQ2&st=MTczMjcwMTI0MCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="70651009"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="70651009"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 70651009; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=70651009]").text(description); $(".js-view-count[data-work-id=70651009]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 70651009; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='70651009']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 70651009, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f50946073a0cbc965d65134875ad6024" } } $('.js-work-strip[data-work-id=70651009]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":70651009,"title":"I虈nsan Prostat Kanseri Hu虉crelerinde D-e-MAPP kaynakl谋 Sitotoksisitenin Aras抬t谋r谋lmas谋 Investigation of D-e-MAPP-derived Cytotoxicity on Human Prostate Cancer Cells","translated_title":"","metadata":{"abstract":"zSfingolipidler, bir莽ok kanserde h眉cre 枚l眉m眉, hayatta kalma ve ila莽 direnci gibi biyolojik i艧lemlerde kritik rol oynamaktad谋r. Seramid ve dihidroseramid, proliferasyon ve 枚l眉me ba臒l谋 olan sfingolipidlerdir. Son kanser ara艧t谋rmalar谋, kanser-sfingolipid metabolizmas谋n谋n netle艧tirilmesine odaklanm谋艧t谋r. Son y谋llarda, sfingolipid metabolizmas谋 ili艧kisinde kilit bir molek眉l olarak seramid, antikanser aktivitesi i莽in seramidaz inhibit枚r uygulamas谋 ile h眉cre i莽i seviyesini artt谋rarak ara艧t谋r谋lm谋艧t谋r. Prostat kanseri, en s谋k g枚r眉len insan kanserleri aras谋ndad谋r ve kansere ba臒l谋 en yayg谋n ikinci 枚l眉m nedeni olarak rapor edilmektedir. Prostat kanseri, 65 ya艧谋ndan b眉y眉klerde yayg谋nd谋r. Bu 莽al谋艧man谋n amac谋, bir seramidaz inhibit枚r眉 olan (1S,2R)-D-erythro-2-(N-Myristoylamino)1-phenyl-1-propanol鈥檜n (D-eritro-MAPP) insan prostat kanseri DU-145 h眉creleri 眉zerindeki potansiyel sitotoksik aktivitesini MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) testi, ak谋艧 sitometrisi, konfokal...","publication_date":{"day":null,"month":null,"year":2019,"errors":{}}},"translated_abstract":"zSfingolipidler, bir莽ok kanserde h眉cre 枚l眉m眉, hayatta kalma ve ila莽 direnci gibi biyolojik i艧lemlerde kritik rol oynamaktad谋r. Seramid ve dihidroseramid, proliferasyon ve 枚l眉me ba臒l谋 olan sfingolipidlerdir. Son kanser ara艧t谋rmalar谋, kanser-sfingolipid metabolizmas谋n谋n netle艧tirilmesine odaklanm谋艧t谋r. Son y谋llarda, sfingolipid metabolizmas谋 ili艧kisinde kilit bir molek眉l olarak seramid, antikanser aktivitesi i莽in seramidaz inhibit枚r uygulamas谋 ile h眉cre i莽i seviyesini artt谋rarak ara艧t谋r谋lm谋艧t谋r. Prostat kanseri, en s谋k g枚r眉len insan kanserleri aras谋ndad谋r ve kansere ba臒l谋 en yayg谋n ikinci 枚l眉m nedeni olarak rapor edilmektedir. Prostat kanseri, 65 ya艧谋ndan b眉y眉klerde yayg谋nd谋r. Bu 莽al谋艧man谋n amac谋, bir seramidaz inhibit枚r眉 olan (1S,2R)-D-erythro-2-(N-Myristoylamino)1-phenyl-1-propanol鈥檜n (D-eritro-MAPP) insan prostat kanseri DU-145 h眉creleri 眉zerindeki potansiyel sitotoksik aktivitesini MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) testi, ak谋艧 sitometrisi, konfokal...","internal_url":"https://www.academia.edu/70651009/I_nsan_Prostat_Kanseri_Hu_crelerinde_D_e_MAPP_kaynakl%C4%B1_Sitotoksisitenin_Aras_t%C4%B1r%C4%B1lmas%C4%B1_Investigation_of_D_e_MAPP_derived_Cytotoxicity_on_Human_Prostate_Cancer_Cells","translated_internal_url":"","created_at":"2022-02-06T00:13:59.151-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":3323325,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":37655050,"work_id":70651009,"tagging_user_id":3323325,"tagged_user_id":109855918,"co_author_invite_id":null,"email":"h***u@eskisehir.edu.tr","affiliation":"Eskisehir Anadolu 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="64673553"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/64673553/Bursa_Aphodiinae_ve_Scarabaeinae_Coleoptera_Scarabaeidae_T%C3%BCrleri_%C3%9Czerine_Faunistik_Bir_%C3%87al%C4%B1%C5%9Fma"><img alt="Research paper thumbnail of Bursa Aphodiinae ve Scarabaeinae (Coleoptera: Scarabaeidae) T眉rleri 脺zerine Faunistik Bir 脟al谋艧ma" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/64673553/Bursa_Aphodiinae_ve_Scarabaeinae_Coleoptera_Scarabaeidae_T%C3%BCrleri_%C3%9Czerine_Faunistik_Bir_%C3%87al%C4%B1%C5%9Fma">Bursa Aphodiinae ve Scarabaeinae (Coleoptera: Scarabaeidae) T眉rleri 脺zerine Faunistik Bir 脟al谋艧ma</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://xn--esog-3ra.academia.edu/DrH%C3%BCseyin%C4%B0zg%C3%B6rd%C3%BC">Dr. H眉seyin 陌zg枚rd眉</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MehmetG%C3%9CLMEZ1">Mehmet G脺LMEZ</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Bu calisma 2006-2007 yillarinda Bursa cevresinde Aphodiinae ve Scarabaeinae turleri uzerine聽 yapi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bu calisma 2006-2007 yillarinda Bursa cevresinde Aphodiinae ve Scarabaeinae turleri uzerine聽 yapilmistir. Bu calismada 8 cinse ait 29 tur bulunmustur. Bulunan her bir turun Turkiye`deki ve Palearktik bolgedeki yayilislari verilmistir. Onthophagus (Amphionthophagus) falzonii Goidanich, 1926, O. (Onthophagus) illyricus (Scopoli, 1763), O. (Palaeonthophagus) coenobita (Herbst, 1783), O. lucidus (Sturm 1800), O. osellai Pittino, 1982, O. similis (Scriba, 1790), O. (Paleonthophagus) medius (Kugelann, 1792) turleri Marmara Bolgesi icin yeni kayittir. Aphodius (Acrossus) luridus (Fabricius, 1775), A. (Calamosternus) granarius (Linnaeus, 1767), A. (Eudolus) quadriguttatus (Herbst, 1783), A. (Melinopterus) prodromus (Brahm, 1790), A. punctatosulcatus (Sturm, 1805), O. (Palaeonthophagus) verticicornis (Laicharting, 1781) turleri Marmara Bolgesinin Anadolu Yakasi icin yeni kayittir.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="64673553"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="64673553"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 64673553; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=64673553]").text(description); $(".js-view-count[data-work-id=64673553]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 64673553; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='64673553']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 64673553, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=64673553]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":64673553,"title":"Bursa Aphodiinae ve Scarabaeinae (Coleoptera: Scarabaeidae) T眉rleri 脺zerine Faunistik Bir 脟al谋艧ma","translated_title":"","metadata":{"abstract":"Bu calisma 2006-2007 yillarinda Bursa cevresinde Aphodiinae ve Scarabaeinae turleri uzerine聽 yapilmistir. Bu calismada 8 cinse ait 29 tur bulunmustur. Bulunan her bir turun Turkiye`deki ve Palearktik bolgedeki yayilislari verilmistir. Onthophagus (Amphionthophagus) falzonii Goidanich, 1926, O. (Onthophagus) illyricus (Scopoli, 1763), O. (Palaeonthophagus) coenobita (Herbst, 1783), O. lucidus (Sturm 1800), O. osellai Pittino, 1982, O. similis (Scriba, 1790), O. (Paleonthophagus) medius (Kugelann, 1792) turleri Marmara Bolgesi icin yeni kayittir. Aphodius (Acrossus) luridus (Fabricius, 1775), A. (Calamosternus) granarius (Linnaeus, 1767), A. (Eudolus) quadriguttatus (Herbst, 1783), A. (Melinopterus) prodromus (Brahm, 1790), A. punctatosulcatus (Sturm, 1805), O. (Palaeonthophagus) verticicornis (Laicharting, 1781) turleri Marmara Bolgesinin Anadolu Yakasi icin yeni kayittir.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}}},"translated_abstract":"Bu calisma 2006-2007 yillarinda Bursa cevresinde Aphodiinae ve Scarabaeinae turleri uzerine聽 yapilmistir. 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Bu calismanin amac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bu calisma 2011 ve 2013 yillarinda 艦anliurfa鈥檔in Horzum Koyunde yurutulmustur. Bu calismanin amaci Horzum koyu bokbocegi faunasini belirlemektir. Sonuc olarak Scarabaeinae ve Aphodiinae altfamilyalari 5 cinse bagli 9 tur icermektedir. Tespit edilen butun turler calisma alani icin yeni kayitlardir. 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Bone cancer is a type of prevalent cancer that occurs both in youngsters and adults. Bone cancer is mostly common in the long bones of the pelvis, arms, and legs. Statistically, more than 200 cases of osteosarcoma have been reported annually in our country. Classical treatment with chemotherapeutics remains ineffective for the cure of this cancer. Recent studies have shown that ceramide induces apoptosis due to its increased levels in the cells. Thus, many studies have been conducted for the accumulation of ceramide molecules in the cell by different ways to induce apoptosis. NOE (N-oleoylethanolamine) is a specific inhibitor of ceramidase enzymes that hydrolyse intracellular ceramides and prevent apoptosis. OBJECTIVE This study investigates the cytotoxic and apoptosis-inducing activities of NOE on human osteosarcoma Saos-2 cells. METHODS Cytotoxic effects were investigated by MTT co...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="64673549"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="64673549"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 64673549; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=64673549]").text(description); $(".js-view-count[data-work-id=64673549]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 64673549; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='64673549']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 64673549, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=64673549]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":64673549,"title":"Cytotoxic Impacts of N-Oleoylethanolamine in Bone Cancer Cells","translated_title":"","metadata":{"abstract":"BACKGROUND Cancer is a complex disease that is derived from the uncontrolled proliferation of cells. 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Bu calismanin amac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Bu calisma 2011 ve 2013 yillarinda 艦anliurfa鈥檔in Horzum Koyunde yurutulmustur. Bu calismanin amaci Horzum koyu bokbocegi faunasini belirlemektir. Sonuc olarak Scarabaeinae ve Aphodiinae altfamilyalari 5 cinse bagli 9 tur icermektedir. Tespit edilen butun turler calisma alani icin yeni kayitlardir. Butun turlerin Turkiye ve Palearktik yayilislari belirlenmistir.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="64673489"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="64673489"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 64673489; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=64673489]").text(description); $(".js-view-count[data-work-id=64673489]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 64673489; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='64673489']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 64673489, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=64673489]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":64673489,"title":"艦anliurfa Horzum K枚y眉 Bok B枚cekleri虈 (Scarabaeidae, Coleoptera) Faunasi 脺zeri虈ne Bir 脰n 脟ali艧ma","translated_title":"","metadata":{"abstract":"Bu calisma 2011 ve 2013 yillarinda 艦anliurfa鈥檔in Horzum Koyunde yurutulmustur. 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Dergisi","grobid_abstract":"Akci臒er kanseri d眉nyada y眉ksek 枚l眉m oranlar谋na sahip olan bir kanser t眉r眉d眉r. Bitkilerde do臒al olarak bulunan polifenollerin antioksidan 枚zellikleri bilinmektedir. Polifenoller biyolojik aktiviteleri, besinsel ve antioksidan de臒erleri sebebiyle ara艧t谋rmalarda yer alm谋艧t谋r. Ellajik asit 莽ilek, k谋z谋lc谋k, ceviz, nar ve ahududu gibi bir莽ok meyvede bulunan do臒al bir bile艧iktir. Ellajik asit antioksidan 枚zellikleri ile bilinen ve insan v眉cudunu zararl谋 serbest radikallerden koruyan bir bile艧iktir. Bu 莽al谋艧mada ellajik asit bir莽ok kanser h眉cresi 眉zerinde h眉cre b眉y眉mesini bask谋lama 枚zelli臒inden dolay谋 akci臒er kanseri A549 h眉crelerinde h眉cre 枚l眉m眉n眉 tetiklemek amac谋yla kullan谋lm谋艧t谋r. A549 h眉crelerine ellajik asidin sitotoksik etkilerini ara艧t谋rmak i莽in MTT (3-(4,5dimethylthiazol-2-yl)-2,5 diphenyl-2H-tetrazolium bromide) tekni臒i kullan谋lm谋艧t谋r. Buna ilaveten ince yap谋sal ve morfolojik de臒i艧iklikler TEM ve konfokal mikroskopi teknikleri kullan谋larak de臒erlendirilmi艧tir. Sitotoksisite test sonu莽lar谋 uygulama dozunun artmas谋 ile h眉cre canl谋l谋臒谋n谋n d眉艧t眉臒眉n眉 g枚stermi艧tir ve morfolojik ve ince yap谋sal analizler bu ajan谋n sitotoksisitesini kromatin yo臒unla艧mas谋, membran tomurcuklanmas谋, krista kayb谋 gibi apoptotik g枚sterge olarak de臒erlendirilen de臒i艧ikliklere yol a莽arak ger莽ekle艧tirdi臒ini g枚stermi艧tir. 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