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This knowledge has greatly expanded our understanding of how cancer develops and progresses. Ultimately, it has led to new ways of diagnosing and treating cancer, as well as new ways of identifying those at high risk of developing cancer. In short, genomics research has changed the way we see cancer.</p> <p>Large-scale research projects such as <a href="https://www.cancer.gov/ccg/research/genome-sequencing/tcga">The Cancer Genome Atlas (TCGA)</a>, and its pediatric counterpart <a href="https://www.cancer.gov/ccg/research/genome-sequencing/target">Therapeutically Applicable Research to Generate Effective Treatments (TARGET)</a>, have surveyed and cataloged the genomic changes in multiple types of cancer. The discovery of novel cancer-associated genetic changes has led to an explosion of <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="b96ba2a5-e27b-4358-991e-db168c8e1c04" href="/about-cancer/treatment/types/targeted-therapies">therapies that target specific changes</a> and <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="97df430a-402e-4239-aa18-4ed819cbfa37" href="/about-cancer/treatment/types/biomarker-testing-cancer-treatment">tests that identify patients</a> whose cancers harbor those changes—an approach to cancer treatment known as precision medicine.</p> <p>Genomics studies have also revealed unexpected genetic similarities across different types of tumors, shifting the way we define cancer. Treatments are typically given based on the tumor’s location in the body, such as the brain or lung. But a <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="47683664-ff9a-4d69-b7e5-6c26e3aba4a1" href="/about-cancer/treatment/drugs/solid-tumors">handful of new cancer drugs</a> are used to treat tumors with specific genetic or molecular features, no matter where in the body the cancer started growing.</p> <p>On the other hand, genomics research has also <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="8aec024b-be6b-4edc-a49b-6b6f6f8b29b9" href="/news-events/cancer-currents-blog/2018/genetic-differences-childhood-adult-aml">shown how different cancers can be</a>, even when they started growing in the same organ. This finding has helped explain why some subtypes of tumors grow at different rates and why cancer treatments don’t work the same way in every patient.</p> <p>NCI plays a key role in large-scale genomics research by facilitating collaborations between scientists of different disciplines, providing funding, and providing access to state-of-the-art technologies, data sets, and <a href="https://www.cancer.gov/research/resources/search?from=0&researchAreas=cancer_omics">other resources</a>.</p> <p>In addition to genomics, cancer researchers are also creating large-scale catalogs of other kinds of molecular changes in cancer, including epigenomic, transcriptomic, proteomic, and metabolomic changes. These studies have further expanded our understanding of cancer and have led to new ideas for treating it.</p> <p>The results of these projects illustrate the wide-ranging variation of genetic and molecular changes in cancer, and provide a better understanding of what causes cancer at the molecular level.</p> </section> </section> <section> <h2 id="selected-nci-activities-in-cancer-genomics-research"> <p>Selected NCI Activities in Cancer Genomics Research</p> </h2> <p style="margin-top:8px; margin-bottom:20px">Exploring the genetic and molecular foundations of cancer is a vital part of NCI’s research efforts. The following list highlights NCI-led or NCI-funded activities related to genomics and other “omics” research.</p> <h3>Building Genomics Data Sets</h3> <p>Large-scale research projects use omics technologies to catalog the molecular changes in multiple types of cancer.</p> <div data-embed-button="cgov_featured_content_button" data-entity-embed-display="view_mode:node.embedded_feature_card" data-entity-type="node" data-entity-uuid="89d50cd7-7e29-48fa-88ad-1f01dc8b3d8c" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity align-right"> <div class="feature-card"> <a href="/research/leading-progress"> <div class="image-hover"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_featured/public/cgov_image/media_image/2024-09/AP-FY26-Web-Graphics_MyNCI-Carousel-Opt2-4x3%20%285%29.jpg?h=cc275ae6&itok=oXaL6C2p" width="425" height="319" alt="Illustration depicting a silhouette of ten people with different ages, backgrounds, and abilities in front of a centrally illuminated blue and red background. A connected series of people icons throughout the image represents data collected from individuals and groups."> </div> <h3>NCI FY26 Annual Plan & Professional Judgment Budget Proposal</h3> <p>Each year, NCI prepares a plan for advancing cancer research and proposes the budget required to fund a broad research portfolio.</p> </a> </div> </div> <ul> <li>The <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="a4b41a53-75da-4745-b76d-3c93fd70c1d0" href="/research/key-initiatives/moonshot-cancer-initiative/implementation/human-tumor-atlas">Human Tumor Atlas Network</a> is constructing 3-dimensional atlases of human cancers as they change over time, including single-cell analyses of genomics, epigenomics, and transcriptomics. The network is generating adult and pediatric atlases and strives to include minority and underserved patients across cancer types and stages of disease.</li> <li>The <a href="https://proteomics.cancer.gov/programs/cptac">Clinical Proteomic Tumor Analysis Consortium</a> is using large-scale proteomic and genomic analyses, or proteogenomics, to characterize multiple types of cancer. The consortium is also using proteogenomics to answer questions about toxicity and resistance in clinical trials of new cancer drugs.</li> <li>NCI leads several projects <a data-entity-substitution="canonical" data-entity-type="media" data-entity-uuid="a1b828c2-f13b-45fa-aa2c-f94823c1211a" href="/research/key-initiatives/moonshot-cancer-initiative/seminar-series/southwestern-tribal-nations-cancer-genome-sequencing-video">to molecularly characterize large collections of cancers</a> as well as collecting a rich profile of clinical features and outcomes. The <a href="https://www.cancer.gov/ccg/research/computational-genomics/genomic-data-analysis-network">Genomic Data Analysis Network</a> develops cutting-edge computational tools and performs an initial analysis of the data from these projects, providing a launching pad for a broad community of researchers.</li> <li>The <a href="https://pe-cgs.org/">Participant Engagement and Cancer Genome Sequencing (PE-CGS) Research Network</a>, a Cancer Moonshot initiative, is using direct participant engagement approaches to promote cancer genome sequencing programs for rare cancers, highly lethal cancers, cancers that occur at an early age, cancers that disproportionately affect certain populations, and cancers that are prevalent in understudied populations. </li> <li>The <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="4e7268fb-a3bb-485d-8640-6ca551b41218" href="/research/areas/childhood/childhood-cancer-data-initiative">Childhood Cancer Data Initiative (CCDI)</a> is gathering clinical care and research data—including genomics data—from children, teens, and young adults with cancer. CCDI has also created infrastructure to share this data with researchers to help them learn faster and on a larger scale than is possible for any single institution.</li> </ul> <h3>Connecting Genomics Data to Cancer Biology</h3> <p>NCI conducts and supports research to find out how genetic and other molecular changes in cancer cells affect cancer development, cancer progression, and treatment response. </p> <div data-embed-button="insert_block_content" data-entity-embed-display="view_mode:block_content.embedded_feature_card" data-entity-type="block_content" data-entity-uuid="20cb5c7a-e9c2-415a-b971-8a7ee7517fd5" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity align-right"> <div class="feature-card"> <a href="https://nationalcancerplan.cancer.gov/goals/develop-effective-treatments"> <div class="image-hover"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_featured/public/cgov_image/media_image/2023-09/NCP-Assets_4x3-Develop%20Effective%20Treatments.jpg?h=b48714fe&itok=_GFjijN6" width="425" height="319" alt="A yellow, circular icon with a photo of a woman in a lab coat, clear safety goggles, and gloves looking to a microscope. Above her are the words Develop Effective Treatments."> </div> <h3>NCI Treatment Research and the National Cancer Plan</h3> <p>NCI supports a broad variety of research that aligns with the National Cancer Plan’s goal to develop effective treatments. Read about the plan and this goal.</p> </a> </div> </div> <ul> <li>The <a href="https://www.cancer.gov/ccg/research/functional-genomics/ctd2">Cancer Target Discovery and Development Program</a> is a network of research centers devoted to studying how molecular changes found in cancers affect cancer cells and explore opportunities to target those changes with new therapies.</li> <li>The <a href="https://epi.grants.cancer.gov/genomic/">Epidemiology and Genomics Research Program</a> supports research in human populations to understand genomic determinants of cancer occurrence and cancer outcomes, and translate findings to clinical and public health interventions.</li> <li>NCI researchers use <a href="https://dceg.cancer.gov/research/how-we-study/Tumor-Profiling">molecular and genomic profiling to study the causes of cancer</a>. This enables a better understanding of how normal cells transform into cancer cells, and to pinpoint internal processes and external exposures associated with specific molecular or genomic subtypes of cancer.</li> <li>The <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="144828a6-5ee5-466b-8ad7-c8700f7db720" href="/about-nci/organization/dcb/research-programs/csbc">Cancer Systems Biology Consortium</a> integrates and analyzes large omics data sets to get a birds-eye view of the molecular changes in cancer, how these changes interact with one another, and how they change over time and space.</li> </ul> <h3>Using Genomics in Clinical Trials</h3> <p>NCI clinical trials are among the first to use genomic testing to match patients to cancer treatments based on the genetic changes in their tumors.</p> <ul> <li><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="dec245c3-d088-4c9f-9c52-84e331254feb" href="/research/infrastructure/clinical-trials/nci-supported/combomatch">ComboMATCH</a> is a group of clinical trials that are using genetic testing to find genetic changes in patients’ cancers and potentially match them to combinations of cancer treatments that target those genetic changes.</li> <li><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="eea287cb-f239-444e-af06-d725b9480068" href="/types/lung/research/alchemist">ALCHEMIST</a> is a set of precision medicine lung cancer trials designed to evaluate whether adding targeted therapy based on patients' tumor genetics can help prevent lung cancer from returning after surgery.</li> <li><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="f2a8ac44-867d-4143-b495-1a3f0eb93bda" href="/research/infrastructure/clinical-trials/nci-supported/pediatric-match">NCI-COG Pediatric MATCH</a> is an international cancer treatment clinical trial for children, teens, and young adults that is testing the use of precision medicine for childhood cancers.</li> </ul> <h3>Genomics Data Sharing </h3> <div data-embed-button="insert_block_content" data-entity-embed-display="view_mode:block_content.embedded_feature_card" data-entity-type="block_content" data-entity-uuid="d91cb3ae-4298-41b0-be79-b246fa996576" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity align-right"> <div class="feature-card"> <a href="https://nationalcancerplan.cancer.gov/goals/maximize-data-utility"> <div class="image-hover"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_featured/public/cgov_image/media_image/2023-09/NCP-Assets_4x3-Maximize%20Data%20Utility_0.jpg?h=b48714fe&itok=1MZS0AZS" width="425" height="319" alt="A yellow, circular icon with a photo of two women looking over notes. Above them are the words Maximize Data Utility."> </div> <h3>NCI, Data Sharing, and the National Cancer Plan</h3> <p>NCI is committed to providing access to research data, including genomic data, to accelerate progress against cancer. That commitment aligns with the National Cancer Plan’s goal to maximize data utility. Read about the plan and this goal.</p> </a> </div> </div> <p>NCI has spearheaded genomic data sharing practices since the first large-scale genomic characterization study, TCGA. <a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="299faa4b-5495-4461-9380-fce2fa93ccff" href="/research/infrastructure/bioinformatics">NCI’s support for cancer omic data sharing</a> continues by striving to make data as accessible as possible while protecting patient privacy.</p> <p>The <a href="https://datacommons.cancer.gov/">Cancer Research Data Commons</a> is a cloud-based data science infrastructure that provides secure access to a large, comprehensive, and expanding collection of cancer research data, including data from TCGA, TARGET, and CCDI. Users can explore and use analytical and visualization tools for data analysis in the cloud.</p> </section> <section> <h2 id="recent-research-findings-in-cancer-genomics"> <p>Recent Research Findings in Cancer Genomics</p> </h2> <ul> <li style="margin-left: 24px; margin-bottom: 11px;"><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="85afa2d1-f278-42ed-a954-a47fbe4d9dea" href="/news-events/press-releases/2024/genomic-analysis-kidney-cancer-risk">Analysis identifies 50 new genomic regions associated with kidney cancer risk</a></li> <li style="margin-left: 24px; margin-bottom: 11px;"><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="8f6d376b-7145-4c23-b471-e7a156281a22" href="/news-events/press-releases/2024/polygenic-risk-scores-for-childhood-cancer-survivors">For childhood cancer survivors, inherited genetic factors influence risk of cancers later in life</a></li> <li style="margin-left: 24px; margin-bottom: 11px;"><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="92aeb559-5a26-421c-be46-a0785b2334bd" href="/news-events/press-releases/2023/combomatch-precision-medicine-cancer-initiative">NCI’s ComboMATCH initiative will test new drug combinations guided by tumor biology</a></li> <li style="margin-left: 24px; margin-bottom: 11px;"><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="6410ff49-fd29-425a-afec-9162a57b07ad" href="/news-events/cancer-currents-blog/2022/meningioma-brain-tumor-new-classifications">New Way to Classify Meningioma Brain Tumors Suggests Potential Treatments</a></li> <li style="margin-left: 24px; margin-bottom: 11px;"><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="c632bf0c-c2fa-4e5d-bf51-78849c775895" href="/news-events/press-releases/2021/lung-cancer-never-smokers">NIH study illuminates origins of lung cancer in never smokers</a></li> <li style="margin-left: 24px; margin-bottom: 11px;"><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="98414c71-cbc7-4292-9125-032a2c93461e" href="/news-events/press-releases/2021/childhood-cancer-rhabdomyosarcoma">International study of rare childhood cancer finds genetic clues, potential for tailored therapy</a></li> <li style="margin-left: 24px; margin-bottom: 11px;"><a data-entity-substitution="canonical" data-entity-type="node" data-entity-uuid="f69b60dc-114f-4b8d-a5f9-f22d0293d0b7" href="/news-events/press-releases/2021/genetic-effects-chernobyl-radiation-exposure">International research teams explore genetic effects of Chernobyl radiation</a></li> </ul> </section> </div> </div> </div> <footer class="article-footer"> <div id="nvcgRelatedResourcesArea"> <div> <aside class="related-resources list"> <h2 class="related-resources__heading">Related Resources</h2> <ul> <li class="general-list-item general list-item title-only"> <div class="title-and-desc title desc container"> <a class="title" href="https://www.cancer.gov/ccg">NCI Center for Cancer Genomics</a> </div> </li> <li class="general-list-item general list-item title-only"> <div class="title-and-desc title desc container"> <a class="title" href="https://datascience.cancer.gov/">NCI Center for Biomedical Informatics & Information Technology</a> </div> </li> <li class="general-list-item general list-item title-only"> <div class="title-and-desc title desc container"> <a class="title" href="https://ccr.cancer.gov">NCI Center for Cancer Research</a> </div> </li> <li class="general-list-item general list-item title-only"> <div class="title-and-desc title desc container"> <a class="title" href="https://cancercontrol.cancer.gov">NCI Division of Cancer Control and Population Sciences</a> </div> </li> <li class="general-list-item general list-item title-only"> <div class="title-and-desc title desc container"> <a class="title" href="https://dceg.cancer.gov">NCI Division of Cancer Epidemiology and Genetics</a> </div> </li> </ul> </aside> </div> </div> <div class="document-dates horizontal"> <ul class="clearfix"> <li> <strong>Updated:</strong> <time datetime="2024-08-14T12:00:00Z">August 14, 2024</time> </li> </ul> </div> <div id="nvcgSlPublicUse"> <div class="slot-item only-SI"> <div class="public-use"> <div id="block-ncids-trans-public-use"> <p><em>If you would like to reproduce some or all of this content, see <a href="/policies/copyright-reuse">Reuse of NCI Information</a> for guidance about copyright and permissions. 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