A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription

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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="d90fFhYIAWcxjY2Al3xYIS3cVVcRvCgb0wOxiWXKKY1vRqoRJ4L9ikTEGsWO1XNo"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="d90fFhYIAWcxjY2Al3xYIS3cVVcRvCgb0wOxiWXKKY1vRqoRJ4L9ikTEGsWO1XNo"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="d90fFhYIAWcxjY2Al3xYIS3cVVcRvCgb0wOxiWXKKY1vRqoRJ4L9ikTEGsWO1XNo"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="d90fFhYIAWcxjY2Al3xYIS3cVVcRvCgb0wOxiWXKKY1vRqoRJ4L9ikTEGsWO1XNo"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="20610623"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" 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data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="d90fFhYIAWcxjY2Al3xYIS3cVVcRvCgb0wOxiWXKKY1vRqoRJ4L9ikTEGsWO1XNo"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" 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University, Cardiff, United Kingdom." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Pajak+B&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bozena Pajak">Bozena Pajak</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Stubbs+M&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Mark Stubbs">Mark Stubbs</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Todd+H&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Helen Todd">Helen Todd</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" 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class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ruddle+R&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ruth Ruddle">Ruth Ruddle</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Samuel+L&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Lee Samuel">Lee Samuel</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Battersby+A&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Alysia Battersby">Alysia Battersby</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Raynaud+F&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" 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<div class="short-view" id="short-view-heading"> <h1 class="heading-title"> A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Kenneth Ewan</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> Cancer Res<span class="citation-separator">.</span> </span> <span class="date"> <time class="citation-year" datetime="2010">2010</time><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/20610623/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div class="display-options" 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data-ga-category="search" data-ga-action="author_link" data-ga-label="Kenneth Ewan">Kenneth Ewan</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="School of Bioscience, Cardiff University, Cardiff, United Kingdom." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Pajak+B&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bozena Pajak">Bozena Pajak</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Stubbs+M&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Mark Stubbs">Mark Stubbs</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Todd+H&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Helen Todd">Helen Todd</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Barbeau+O&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Olivier Barbeau">Olivier Barbeau</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Quevedo+C&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Camilo Quevedo">Camilo Quevedo</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Botfield+H&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Hannah Botfield">Hannah Botfield</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Young+R&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rodrigo Young">Rodrigo Young</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ruddle+R&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Ruth Ruddle">Ruth Ruddle</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Samuel+L&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Lee Samuel">Lee Samuel</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Battersby+A&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Alysia Battersby">Alysia Battersby</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Raynaud+F&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Florence Raynaud">Florence Raynaud</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Allen+N&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Nicholas Allen">Nicholas Allen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wilson+S&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Stephen Wilson">Stephen Wilson</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Latinkic+B&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Branko Latinkic">Branko Latinkic</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Workman+P&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Paul Workman">Paul Workman</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=McDonald+E&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Edward McDonald">Edward McDonald</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Blagg+J&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Julian Blagg">Julian Blagg</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Aherne+W&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Wynne Aherne">Wynne Aherne</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Dale+T&cauthor_id=20610623" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Trevor Dale">Trevor Dale</a></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> School of Bioscience, Cardiff University, Cardiff, United Kingdom.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">20610623</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC2912498&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2912498/" data-ga-category="full_text" data-ga-action="PMCID" > PMC2912498 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1158/0008-5472.CAN-10-1028&id_type=DOI" href="https://doi.org/10.1158/0008-5472.can-10-1028" data-ga-category="full_text" data-ga-action="DOI" > 10.1158/0008-5472.CAN-10-1028 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/20610623/citations/" data-citation-style="nlm" data-pubmed-format-link="/20610623/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> The Wnt signaling pathway is frequently deregulated in cancer due to mutations in genes encoding APC, beta-catenin, and axin. To identify small-molecule inhibitors of Wnt signaling as potential therapeutics, a diverse chemical library was screened using a transcription factor reporter cell line in which the activity of the pathway was induced at the level of Disheveled protein. A series of deconvolution studies was used to focus on three compound series that selectively killed cancer cell lines with constitutive Wnt signaling. Activities of the compounds included the ability to induce degradation of beta-catenin that had been stabilized by a glycogen synthase kinase-3 (GSK-3) inhibitor. This screen illustrates a practical approach to identify small-molecule inhibitors of Wnt signaling that can seed the development of agents suitable to treat patients with Wnt-dependent tumors. </p> </div> </div> <p class="copyright" id="copyright"> (c)2010 AACR. </p> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="fig-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/2912498/23219e4b96a4/ukmss-30983-f0001.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="500" data-image-height="603" data-image-alt="Fig. 1" data-pmc-id="PMC2912498" data-figure-id="F1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/2912498/1b21ca73d5d5/ukmss-30983-f0001.gif" alt="Fig. 1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="500"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="603"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 1. Primary screen </p> </strong> <div class="figure-caption-contents"><b> a </b> . pathway…</div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 1. Primary screen </p> </strong> <div class="figure-caption-contents"><b> a </b> . pathway activators (see text) that were used to induce…</div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 1. Primary screen </strong> <div class="figure-caption-contents"><b>a</b>. pathway activators (see text) that were used to induce Wnt/β-catenin signaling at distinct levels. <b>b</b>. the reporter construct used in the human epithelial HEK293-based cell line. The bicistronic TCF-luciferase-IRES-GFP reporter contained the Wnt response element from the Xnr3 promoter and four TCF binding sites. <b>c</b>. fold induction, coefficients of variation, and Z'-factors following 24 h estradiol and lithium induction. <b>d</b>. subset of thirteen 384-well plates (alternate shades of gray) and DMSO control plates (black) from the primary screen data. The dotted line indicates 50% inhibition of estradiol induction.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="fig-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/2912498/45a770cafbe4/ukmss-30983-f0002.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="500" data-image-height="793" data-image-alt="Fig 2" data-pmc-id="PMC2912498" data-figure-id="F2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/2912498/fc9a64e009d0/ukmss-30983-f0002.gif" alt="Fig 2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="500"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="793"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig 2. Hit triage and deconvolution </p> </strong> <div class="figure-caption-contents"><b> a… </b></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig 2. Hit triage and deconvolution </p> </strong> <div class="figure-caption-contents"><b> a </b> . Compound attrition flow diagram leading to selected…</div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig 2. Hit triage and deconvolution </strong> <div class="figure-caption-contents"><b>a</b>. Compound attrition flow diagram leading to selected hits. <b>b</b>. Structures of the three hit compounds CCT031374, CCT036477 and CCT070535. <b>c</b>. Summary of the effects of 30<i>μ</i>M CCT031374, CCT036477 and CCT070535 on TCF-dependent transcription induced at different levels of the Wnt pathway. Control Gal4-luciferase reporter activity was induced by VP16-Gal4.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="fig-3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/2912498/318c8fd11e0d/ukmss-30983-f0003.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="500" data-image-height="781" data-image-alt="Fig 3" data-pmc-id="PMC2912498" data-figure-id="F3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/2912498/b4163c2ab8eb/ukmss-30983-f0003.gif" alt="Fig 3" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="500"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="781"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig 3. Prevention of β-catenin stabilisation by… </p> </strong> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig 3. Prevention of β-catenin stabilisation by CCT031374 </p> </strong> <div class="figure-caption-contents"><b> a </b> . <i> β </i> -catenin abundance in Western…</div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig 3. Prevention of β-catenin stabilisation by CCT031374 </strong> <div class="figure-caption-contents"><b>a</b>. <i>β</i>-catenin abundance in Western blots of lysates from mouse L-cells treated for 6h with 7.5<i>μ</i>M BIO and 20<i>μ</i>M of the indicated hit compounds. <b>b</b>. Decreased abundance of <i>β</i>-catenin in immunostained mouse L-cells and in Western blots of lysates from mouse L-cells treated with indicated concentrations of CCT031374 and 7.5<i>μ</i>M BIO for 8h. Decreases of relative β-catenin/β-actin ratios in the Western blot were normalised to BIO (100%) and control (0%). Bar: 30<i>μ</i>m <b>c</b>. Structures of analogues of CCT031374. CCT031374 is compound (1). EN300-05350 [compound (11)] is a structurally unrelated control of similar lipophilicity, pKa and H-bonding. <b>d</b>. IC50 values from reporter cell assays and Western blots of lysates from mouse L-cell using CCT031374 and its analogues. Key: Asterisks - no effect at the maximum concentration used; +. Compound (8) was toxic to mouse L-cells at this concentration (30<i>μ</i>M); §. assay not done.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="3" data-label-slug="fig-4"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/2912498/12642f591e7d/ukmss-30983-f0004.jpg" itemprop="contentUrl" aria-describedby="figure-caption-3" role="button" data-image-width="437" data-image-height="600" data-image-alt="Fig 4" data-pmc-id="PMC2912498" data-figure-id="F4"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-3" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/2912498/7981a6072fc0/ukmss-30983-f0004.gif" alt="Fig 4" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="437"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="600"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig 4. <underline> M </underline> echanism of action of… </p> </strong> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig 4. <underline> M </underline> echanism of action of CCT031374 </p> </strong> <div class="figure-caption-contents"><b> a </b> . CCT031374 and β-catenin degradation in mouse…</div> </div> <figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig 4. <underline>M</underline>echanism of action of CCT031374 </strong> <div class="figure-caption-contents"><b>a</b>. CCT031374 and β-catenin degradation in mouse L-cells. Western blots and autoradiographs of lysates of mouse L-cells that were exposed to BIO (7.5<i>μ</i>M) for 6h prior to addition of CCT031374 (20<i>μ</i>M) in the presence of BIO for the times shown. CCT031374 (20<i>μ</i>M) increased turnover of <sup>35</sup>S-pulse labelled <i>β</i>-catenin. BIO (7.5<i>μ</i>M) was present throughout labelling and chase periods. Western blots of lysates from mouse L-cells after 240min of treatment with 20<i>μ</i>M CCT031374 after 6 hours of 50<i>μ</i>M MG132 proteasomal inhibitor or 6 hours of coincubation of CCT031374 with 50<i>μ</i>M MG132 (+). <b>b</b>. CCT031374 does not prevent BIO's inhibition of Tau phosphorylation by GSK3. Western blots of lysates from HEK293 cells that had been transfected with expression plasmids for Tau and GSK3<i>β</i> as indicated and had been treated with BIO (7.5<i>μ</i>M) for 4h or with both BIO and CCT031374 (20<i>μ</i>M) for the indicated time periods. Relative phosphorylated: total Tau levels were quantified. <b>c</b>. CCT031374 decreased ‘free’ <i>β</i>-catenin levels in HEK293 cells but not in SW480 cells. ‘Free’ β-catenin was isolated from cell lysates by pull down with a GST-E-cadherin fusion protein. <b>d</b>. CCT031374 treatment of SW480 cells decreased TCF-dependent transcription of Topflash luciferase reporter. SW480 cells were transfected with Topflash reporter, then exposed to compound for 24h. Reporter activity was normalised to co-transfected TK-renilla luciferase activity.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="4" data-label-slug="fig-5"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/2912498/8974aa2d4042/ukmss-30983-f0005.jpg" itemprop="contentUrl" aria-describedby="figure-caption-4" role="button" data-image-width="410" data-image-height="632" data-image-alt="Fig 5" data-pmc-id="PMC2912498" data-figure-id="F5"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-4" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7af/2912498/fb67aad7eda1/ukmss-30983-f0005.gif" alt="Fig 5" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="410"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="632"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig 5. Effect of compounds on Wnt… </p> </strong> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig 5. Effect of compounds on Wnt target gene expression and development </p> </strong> <div class="figure-caption-contents"><b> a </b> . HEK293…</div> </div> <figcaption id="figure-caption-4" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig 5. Effect of compounds on Wnt target gene expression and development </strong> <div class="figure-caption-contents"><b>a</b>. HEK293 cells were transfected with <i>CMYC</i>-luc or <i>SURVIVIN</i>-luc promoter-reporter constructs together with Axin-GID inducer and exposed to 40<i>μ</i>M compound for 24h. Reporter activity was normalised to expression from a co-transfected CMV-lacZ reporter. <b>b</b>. CCT031374, at 20 μmol/L, repressed BIO-induced LEF1 expression in human neurogenic embryoid bodies exposed to 3 μmol/L BIO and CCT031374 for 24 h. The relative abundance of LEF1 was normalized to ACTB. CCT036477 decreased Siamois and Xnr3 expression in Xenopus animal cap assays. Animal caps were treated with 0.3 mol/L LiCl for 10 min, then incubated in medium with or without CCT036477 for 3 h. RNA from NF stage 10.5 embryos provided a second positive control. <b>c</b>. CCT036477 inhibited the development of Xenopus anterior head structures such as the eye (indicated with an arrow) and the cement gland. Embryos were exposed to DMSO or 75<i>μ</i>M CCT036477 from the 4-16 cell stage to NF stage 38. <b>d.</b> CCT036477 induced head and tail patterning defects (indicated with arrows) in Zebrafish embryos. Zebrafish embryos were exposed to 1% DMSO or 20<i>μ</i>M CCT036477 from fertilisation until mid-gastrulation. A range of mild to severe head patterning and tail patterning phenotypes were seen.</div> </figcaption> </figure> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom in/out"></button>   <div class="pswp__preloader"> <div class="pswp__preloader__icn"> <div class="pswp__preloader__cut"> <div class="pswp__preloader__donut"></div> </div> </div> </div> </div> <div class="pswp__share-modal pswp__share-modal--hidden pswp__single-tap"> <div class="pswp__share-tooltip"></div> </div> <button class="pswp__button pswp__button--arrow--left" title="Previous (arrow left)"> </button> <button class="pswp__button pswp__button--arrow--right" title="Next (arrow right)"> </button> <div class="pswp__caption"> <div class="pswp__caption__center"></div> </div> </div> </div> </div> <div class="figure-dialog-caption"> <div class="figure-caption-link-container"> <a class="figure-caption-link" href="#">See this image and copyright information in PMC</a> </div> <div class="figure-caption-center" data-expand-title="click to show full caption" data-collapse-title="click to hide full caption"> </div> <button class="figure-caption-toggle-btn" aria-label="show full caption" data-expand-text="show full caption" data-collapse-text="hide full caption">  </button> </div> </div> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/21393571/" ref="article_id=21393571&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="21393571" data-ga-label=""> An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Gonsalves FC, Klein K, Carson BB, Katz S, Ekas LA, Evans S, Nagourney R, Cardozo T, Brown AM, DasGupta R.</span> <span class="docsum-authors short-authors">Gonsalves FC, et al.</span> <span class="docsum-journal-citation full-journal-citation">Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5954-63. doi: 10.1073/pnas.1017496108. 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A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected] Proc Natl Acad Sci U S A. 2004;101:12682–7. - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC515116/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="PMC515116" > PMC </a> - <a class="reference-link" href="/15314234/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="15314234" > PubMed </a> </li> </ol> </li> </ol> <div class="actions-bar"> <button class="show-all" ref="linksrc=show_all_references_link" aria-controls="top-references-list-1" data-next-page-url="/20610623/references/" data-ga-category="reference" data-ga-action="show_more" > Show all 42 references </button> </div> </div> </div> </div> <div id="publication-types" class="publication-types keywords-section"> <h2 class="title"> Publication types </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button 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dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Wnt Proteins/genetics"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Wnt Proteins/genetics"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Wnt Proteins / metabolism" tabindex="0" aria-controls="keyword-actions-mesh-terms-12" aria-expanded="false" data-pinger-ignore> Wnt Proteins / metabolism </button><div id="keyword-actions-mesh-terms-12" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Wnt Proteins / metabolism"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Wnt+Proteins%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc" 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dropdown-block-link" href="/?term=%22Zebrafish%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Zebrafish%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Zebrafish"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Zebrafish"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Zebrafish" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Zebrafish"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Zebrafish"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Zebrafish"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Antineoplastic Agents" tabindex="0" aria-controls="keyword-actions-substances-0" aria-expanded="false" data-pinger-ignore> Antineoplastic Agents </button><div id="keyword-actions-substances-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Antineoplastic Agents"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Antineoplastic+Agents%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Antineoplastic+Agents%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Antineoplastic Agents"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Antineoplastic Agents"> Search in PubMed 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hidden aria-label="Dropdown menu for keyword Wnt Proteins"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Wnt+Proteins%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Wnt+Proteins%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Wnt Proteins"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Wnt Proteins"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Wnt+Proteins%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Wnt Proteins"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Wnt Proteins"[nm]" data-ga-category="search" data-ga-action="add_to_search" 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A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription - PubMed