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aria-label="個人用ツール" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">個人用ツール</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="利用者メニュー" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_ja.wikipedia.org&uselang=ja"><span>寄付</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=%E7%89%B9%E5%88%A5:%E3%82%A2%E3%82%AB%E3%82%A6%E3%83%B3%E3%83%88%E4%BD%9C%E6%88%90&returnto=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4" title="アカウントを作成してログインすることをお勧めしますが、必須ではありません"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>アカウント作成</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=%E7%89%B9%E5%88%A5:%E3%83%AD%E3%82%B0%E3%82%A4%E3%83%B3&returnto=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4" title="ログインすることを推奨します。ただし、必須ではありません。 [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>ログイン</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> ログアウトした編集者のページ <a href="/wiki/Wikipedia:%E3%82%A6%E3%82%A3%E3%82%AD%E3%83%9A%E3%83%87%E3%82%A3%E3%82%A2%E3%81%B8%E3%82%88%E3%81%86%E3%81%93%E3%81%9D" aria-label="編集の詳細"><span>もっと詳しく</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/%E7%89%B9%E5%88%A5:%E8%87%AA%E5%88%86%E3%81%AE%E6%8A%95%E7%A8%BF%E8%A8%98%E9%8C%B2" title="このIPアドレスからなされた編集の一覧 [y]" accesskey="y"><span>投稿記録</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/%E7%89%B9%E5%88%A5:%E3%83%88%E3%83%BC%E3%82%AF%E3%83%9A%E3%83%BC%E3%82%B8" title="このIPアドレスからなされた編集についての議論 [n]" accesskey="n"><span>トーク</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="サイト"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="目次" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">目次</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">サイドバーに移動</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">非表示</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">ページ先頭</div> </a> </li> <li id="toc-目的" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#目的"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>目的</span> </div> </a> <ul id="toc-目的-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-メカニズム" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#メカニズム"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>メカニズム</span> </div> </a> <ul id="toc-メカニズム-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-発見" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#発見"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>発見</span> </div> </a> <ul id="toc-発見-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-薬物動態" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#薬物動態"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>薬物動態</span> </div> </a> <ul id="toc-薬物動態-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-利用" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#利用"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>利用</span> </div> </a> <ul id="toc-利用-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-用語" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#用語"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>用語</span> </div> </a> <ul id="toc-用語-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-持効性注射剤" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#持効性注射剤"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>持効性注射剤</span> </div> </a> <ul id="toc-持効性注射剤-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-出典" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#出典"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>出典</span> </div> </a> <ul id="toc-出典-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="目次" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="目次の表示・非表示を切り替え" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">目次の表示・非表示を切り替え</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">持効性注射剤</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="特定の記事の別の言語版に移動します。利用可能な言語5件" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-5" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">5の言語版</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%AD%D9%82%D9%86%D8%A9_%D9%85%D8%AF%D8%AE%D8%B1%D9%8A%D8%A9" title="アラビア語: حقنة مدخرية" lang="ar" hreflang="ar" data-title="حقنة مدخرية" data-language-autonym="العربية" data-language-local-name="アラビア語" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Depot_injection" title="英語: Depot injection" lang="en" hreflang="en" data-title="Depot injection" data-language-autonym="English" data-language-local-name="英語" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Injection_retard" title="フランス語: Injection retard" lang="fr" hreflang="fr" data-title="Injection retard" data-language-autonym="Français" data-language-local-name="フランス語" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Iniezione_di_deposito" title="イタリア語: Iniezione di deposito" lang="it" hreflang="it" data-title="Iniezione di deposito" data-language-autonym="Italiano" data-language-local-name="イタリア語" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Depo_i%C4%9Fne" title="トルコ語: Depo iğne" lang="tr" hreflang="tr" data-title="Depo iğne" data-language-autonym="Türkçe" data-language-local-name="トルコ語" class="interlanguage-link-target"><span>Türkçe</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q98079408#sitelinks-wikipedia" title="言語間リンクを編集" class="wbc-editpage">リンクを編集</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="名前空間"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4" title="本文を閲覧 [c]" accesskey="c"><span>ページ</span></a></li><li id="ca-talk" class="new vector-tab-noicon mw-list-item"><a href="/w/index.php?title=%E3%83%8E%E3%83%BC%E3%83%88:%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4&action=edit&redlink=1" rel="discussion" class="new" title="「本文ページについての議論」 (存在しないページ) [t]" accesskey="t"><span>ノート</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="別の言語に切り替える" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">日本語</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="表示"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4"><span>閲覧</span></a></li><li id="ca-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4&action=edit" title="このページのソースコードを編集する [e]" accesskey="e"><span>編集</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4&action=history" title="このページの過去の版 [h]" accesskey="h"><span>履歴表示</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="ページツール"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="ツール" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">ツール</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">ツール</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">サイドバーに移動</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">非表示</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="その他の操作" > <div class="vector-menu-heading"> 操作 </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4"><span>閲覧</span></a></li><li id="ca-more-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4&action=edit" title="このページのソースコードを編集する [e]" accesskey="e"><span>編集</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4&action=history"><span>履歴表示</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> 全般 </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a 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data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">出典: フリー百科事典『ウィキペディア（Wikipedia）』</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="ja" dir="ltr"><figure typeof="mw:File/Thumb"><a href="/wiki/%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB:Risperdal_Consta_injection_syringe.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Risperdal_Consta_injection_syringe.jpg/250px-Risperdal_Consta_injection_syringe.jpg" decoding="async" width="250" height="232" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Risperdal_Consta_injection_syringe.jpg/375px-Risperdal_Consta_injection_syringe.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/39/Risperdal_Consta_injection_syringe.jpg/500px-Risperdal_Consta_injection_syringe.jpg 2x" data-file-width="1033" data-file-height="957" /></a><figcaption>抗精神病薬の持効性注射剤である<a href="/wiki/%E3%83%AA%E3%82%B9%E3%83%91%E3%83%80%E3%83%BC%E3%83%AB%E3%83%BB%E3%82%B3%E3%83%B3%E3%82%B9%E3%82%BF" title="リスパダール・コンスタ">リスパダール・コンスタ</a></figcaption></figure> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB:Depo-testosterone_200_mg_ml.jpg" class="mw-file-description"><img alt="筋注テストステロンデポのバイアル" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c2/Depo-testosterone_200_mg_ml.jpg/220px-Depo-testosterone_200_mg_ml.jpg" decoding="async" width="220" height="308" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c2/Depo-testosterone_200_mg_ml.jpg/330px-Depo-testosterone_200_mg_ml.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c2/Depo-testosterone_200_mg_ml.jpg/440px-Depo-testosterone_200_mg_ml.jpg 2x" data-file-width="2000" data-file-height="2800" /></a><figcaption>筋注<a href="/wiki/%E3%83%86%E3%82%B9%E3%83%88%E3%82%B9%E3%83%86%E3%83%AD%E3%83%B3" title="テストステロン">テストステロン</a>の持効性注射剤のバイアル</figcaption></figure> <p><b>持効性注射剤</b>（じこうせいちゅうしゃざい、<a href="/wiki/%E8%8B%B1%E8%AA%9E" title="英語">英</a>: <span lang="en">long-acting injectable</span>(<b>LAI</b>) 、<a href="/wiki/%E8%8B%B1%E8%AA%9E" title="英語">英</a>: <span lang="en">Depot injection</span>、デポ剤）は、薬剤を徐放性に設計した注射製剤のこと<sup id="cite_ref-guideline2022_1-0" class="reference"><a href="#cite_note-guideline2022-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>。持効性注射剤の導入により投薬の頻度を減らすことが可能となる。持効性注射剤は、特に薬を飲み忘れやすい患者の<a href="/wiki/%E6%9C%8D%E8%96%AC%E3%82%B3%E3%83%B3%E3%83%97%E3%83%A9%E3%82%A4%E3%82%A2%E3%83%B3%E3%82%B9#アドヒアランス" title="服薬コンプライアンス">服薬アドヒアランス</a>の向上や治療の<a href="/wiki/%E4%B8%80%E8%B2%AB%E6%80%A7" class="mw-disambig" title="一貫性">一貫性</a>を高める目的で設計されている。<a href="/wiki/%E3%83%97%E3%83%AD%E3%83%89%E3%83%A9%E3%83%83%E3%82%B0" title="プロドラッグ">プロドラッグ</a>のように薬剤分子自体を改変する方法や、油性・脂質懸濁液などの投与方法を変更することで製剤化される。作用が1か月以上持続する場合があり、<a href="/wiki/%E6%8A%97%E7%B2%BE%E7%A5%9E%E7%97%85%E8%96%AC" title="抗精神病薬">抗精神病薬</a>や<a href="/wiki/%E3%83%9B%E3%83%AB%E3%83%A2%E3%83%B3" title="ホルモン">ホルモン</a>剤など多くの種類の薬剤で利用可能である<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>。 </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="目的"><span id=".E7.9B.AE.E7.9A.84"></span>目的</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4&action=edit&section=1" title="節を編集: 目的"><span>編集</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>持効性注射剤は、血液中に徐々に吸収されることによって薬剤の作用期間を延長する。通常、<a href="/wiki/%E7%AD%8B%E8%82%89%E6%B3%A8%E5%B0%84" class="mw-redirect" title="筋肉注射">筋肉注射</a>、<a href="/w/index.php?title=%E7%9A%AE%E5%86%85%E6%B3%A8%E5%B0%84&action=edit&redlink=1" class="new" title="「皮内注射」 (存在しないページ)">皮内注射</a>、または<a href="/wiki/%E7%9A%AE%E4%B8%8B%E6%B3%A8%E5%B0%84" class="mw-redirect" title="皮下注射">皮下注射</a>として投与される。投与された薬剤は、血流に徐々に放出される。この製剤は薬の飲み忘れが懸念される患者に使用されることがある。しかし、一部の医師や患者の間では、持効性注射剤の使用を強制投与とみなされる場合もあり、そのため使用に反対する意見もある<sup id="cite_ref-Persistent_Barriers_to_the_Use_of_L_3-0" class="reference"><a href="#cite_note-Persistent_Barriers_to_the_Use_of_L-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>。 </p> <div class="mw-heading mw-heading2"><h2 id="メカニズム"><span id=".E3.83.A1.E3.82.AB.E3.83.8B.E3.82.BA.E3.83.A0"></span>メカニズム</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4&action=edit&section=2" title="節を編集: メカニズム"><span>編集</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="rellink" style="margin-bottom: 0.5em; padding-left: 2em; font-size: 90%;" role="note">→詳細は「<span title="リンク先の項目はまだありません。新規の執筆や他言語版からの翻訳が望まれます。"><a href="/w/index.php?title=%E5%BE%90%E6%94%BE%E6%80%A7%E8%A3%BD%E5%89%A4&action=edit&redlink=1" class="new" title="「徐放性製剤」 (存在しないページ)">徐放性製剤</a><span style="font-size: 0.77em; font-weight: normal;" class="noprint">（<a href="https://en.wikipedia.org/wiki/Modified-release_dosage" class="extiw" title="en:Modified-release dosage">英語版</a>）</span></span>」を参照</div><p> 薬剤は、体内で徐々に活性化されるよう設計されるか、または徐々に吸収されるよう設計される。多くの場合、薬剤は有機油に溶解される。この場合、薬剤は<a href="/wiki/%E8%84%82%E6%BA%B6%E6%80%A7" class="mw-redirect" title="脂溶性">脂溶性</a>を持ち、<a href="/wiki/%E3%83%87%E3%82%AB%E3%83%B3%E9%85%B8" class="mw-redirect" title="デカン酸">デカン酸</a>などの官能基を追加することで緩やかな作用を提供する<sup id="cite_ref-Kennedy_2012_4-0" class="reference"><a href="#cite_note-Kennedy_2012-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>。油性基剤との組み合わせにより、薬剤の完全な放出が抑えられ、作用期間が2 - 4週間、またはそれ以上に延びる場合がある<sup id="cite_ref-Kennedy_2012_4-1" class="reference"><a href="#cite_note-Kennedy_2012-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Carpenter_et_al_2018_5-0" class="reference"><a href="#cite_note-Carpenter_et_al_2018-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>。 </p><p>抗精神病薬の場合は、薬剤の<a href="/wiki/%E8%96%AC%E7%89%A9%E5%8B%95%E6%85%8B%E5%AD%A6" title="薬物動態学">薬物動態学</a>（吸収および活性化）の改変は、副作用プロファイルを変更しないため、<a href="/wiki/%E9%9D%9E%E5%AE%9A%E5%9E%8B%E6%8A%97%E7%B2%BE%E7%A5%9E%E7%97%85%E8%96%AC" title="非定型抗精神病薬">非定型抗精神病薬</a>が依然として<a href="/wiki/%E5%AE%9A%E5%9E%8B%E6%8A%97%E7%B2%BE%E7%A5%9E%E7%97%85%E8%96%AC" class="mw-redirect" title="定型抗精神病薬">定型抗精神病薬</a>よりも好まれる<sup id="cite_ref-Carpenter_et_al_2018_5-1" class="reference"><a href="#cite_note-Carpenter_et_al_2018-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>。 </p> <div class="mw-heading mw-heading2"><h2 id="発見"><span id=".E7.99.BA.E8.A6.8B"></span>発見</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4&action=edit&section=3" title="節を編集: 発見"><span>編集</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>最初に開発された持効性注射剤は<a href="/wiki/%E6%8A%97%E7%B2%BE%E7%A5%9E%E7%97%85%E8%96%AC" title="抗精神病薬">抗精神病薬</a>の<a href="/wiki/%E3%83%95%E3%83%AB%E3%83%95%E3%82%A7%E3%83%8A%E3%82%B8%E3%83%B3" title="フルフェナジン">フルフェナジン</a>であり、1966年にエナント酸フルフェナジンが誕生し、1968年にはデカン酸フルフェナジンが登場した<sup id="cite_ref-Kennedy_2012_4-2" class="reference"><a href="#cite_note-Kennedy_2012-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup>。持効性注射剤の概念は1950年以前から登場し、当初は抗生物質の注射製剤として投与頻度を減らす目的で使用されていた<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>。 </p> <div class="mw-heading mw-heading2"><h2 id="薬物動態"><span id=".E8.96.AC.E7.89.A9.E5.8B.95.E6.85.8B"></span>薬物動態</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4&action=edit&section=4" title="節を編集: 薬物動態"><span>編集</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>持効性注射座は、一般に2 - 4週間の作用期間を持つよう設計されるが<sup id="cite_ref-Wright_8-0" class="reference"><a href="#cite_note-Wright-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup>、製剤の種類により薬物動態は異なる場合がある。薬剤自体を改変（例：官能基の付加）するか、製剤を変更（例：油性または<a href="/w/index.php?title=%E3%83%9E%E3%82%A4%E3%82%AF%E3%83%AD%E3%82%B9%E3%83%95%E3%82%A3%E3%82%A2&action=edit&redlink=1" class="new" title="「マイクロスフィア」 (存在しないページ)">マイクロスフィア</a>調製）することで、吸収および代謝に影響を与えることができる<sup id="cite_ref-Wright_8-1" class="reference"><a href="#cite_note-Wright-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup>。持効性注射剤を繰り返し投与することで、薬剤の半減期が1か月以上になることがある（例：<a href="/wiki/%E3%83%95%E3%83%AB%E3%83%95%E3%82%A7%E3%83%8A%E3%82%B8%E3%83%B3" title="フルフェナジン">フルフェナジン</a>の一部の製剤）。ただし、患者によって変動する場合がある<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup>。 </p><p>ホルモンの持効性注射剤の例として、<a href="/wiki/%E3%82%A8%E3%82%B9%E3%83%88%E3%83%A9%E3%82%B8%E3%82%AA%E3%83%BC%E3%83%AB" title="エストラジオール">エストラジオール</a>の作用期間は1週間から1か月以上に及ぶ場合がある<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup>。 </p> <div class="mw-heading mw-heading2"><h2 id="利用"><span id=".E5.88.A9.E7.94.A8"></span>利用</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4&action=edit&section=5" title="節を編集: 利用"><span>編集</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>持効性注射剤は多くの<a href="/wiki/%E5%AE%9A%E5%9E%8B%E6%8A%97%E7%B2%BE%E7%A5%9E%E7%97%85%E8%96%AC" class="mw-redirect" title="定型抗精神病薬">定型抗精神病薬</a>および<a href="/wiki/%E9%9D%9E%E5%AE%9A%E5%9E%8B%E6%8A%97%E7%B2%BE%E7%A5%9E%E7%97%85%E8%96%AC" title="非定型抗精神病薬">非定型抗精神病薬</a>、一部のホルモン製剤や<a href="/wiki/%E3%82%AA%E3%83%94%E3%82%AA%E3%82%A4%E3%83%89%E4%BD%BF%E7%94%A8%E9%9A%9C%E5%AE%B3" title="オピオイド使用障害">オピオイド使用障害</a>治療薬として利用されている<sup id="cite_ref-CNSSpectrums_11-0" class="reference"><a href="#cite_note-CNSSpectrums-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Persistent_Barriers_to_the_Use_of_L_3-1" class="reference"><a href="#cite_note-Persistent_Barriers_to_the_Use_of_L-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>。抗精神病薬の持効性注射剤は、<a href="/wiki/%E7%B5%B1%E5%90%88%E5%A4%B1%E8%AA%BF%E7%97%87" title="統合失調症">統合失調症</a>などの疾患を持つ患者の低い服薬アドヒアランスを改善するために使用される<sup id="cite_ref-CNSSpectrums_11-1" class="reference"><a href="#cite_note-CNSSpectrums-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup>。製品によっては医師や看護師が投与するものもあれば、患者が自己投与できるよう設計されているものもある<sup id="cite_ref-Malawi_14-0" class="reference"><a href="#cite_note-Malawi-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup>。自己投与可能な持効性注射剤は、特に<a href="/wiki/%E7%99%BA%E5%B1%95%E9%80%94%E4%B8%8A%E5%9B%BD" class="mw-redirect" title="発展途上国">発展途上国</a>において、医療アクセスを拡大し、医師の受診頻度を減少させるために利用される<sup id="cite_ref-Malawi_14-1" class="reference"><a href="#cite_note-Malawi-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup>。 </p><p><a href="/wiki/%E3%82%A4%E3%83%B3%E3%82%B9%E3%83%AA%E3%83%B3" title="インスリン">インスリン</a>も製剤によっては持効性注射剤とみなされる場合がある。例えば、<a href="/wiki/%E3%82%A4%E3%83%B3%E3%82%B9%E3%83%AA%E3%83%B3_%E3%82%B0%E3%83%A9%E3%83%AB%E3%82%AE%E3%83%B3" title="インスリングラルギン">インスリングラルギン</a>は注射後に沈殿し、通常<a href="/wiki/%E3%82%A4%E3%83%B3%E3%82%B9%E3%83%AA%E3%83%B3" title="インスリン">インスリン</a>よりも長期間にわたって体内に吸収されるよう設計されている<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup>。持効性インスリンの研究では、体内の自然な基礎インスリン分泌を模倣するための技術開発が進められている<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup>。 </p> <div class="mw-heading mw-heading2"><h2 id="用語"><span id=".E7.94.A8.E8.AA.9E"></span>用語</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4&action=edit&section=6" title="節を編集: 用語"><span>編集</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>日本神経精神薬理学会が編集している「統合失調症薬物治療ガイドライン」では持効性注射剤という用語が用いられている<sup id="cite_ref-guideline2022_1-1" class="reference"><a href="#cite_note-guideline2022-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>。英語では以前は、デポ剤（Depot Injection）と呼ばれていた。初期のデポ剤は、主に油性基剤を用いた製剤が主流であったが、製剤技術の進化により、水性基剤やポリマーを利用した製剤が登場した。これに伴い、「デポ剤」という用語は、油性基剤を想起させることもあり、より包括的で技術の進化を反映したLAI（Long-Acting Injectable）という表現が主流となった。また、「デポ」という言葉が「貯め込む」というニュアンスを持つため、患者に不安感を与える可能性があることが指摘され、より中立的で柔らかい表現として「LAI」が使われるようになった<sup id="cite_ref-Bosnac2015_17-0" class="reference"><a href="#cite_note-Bosnac2015-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup>。 </p> <div class="mw-heading mw-heading2"><h2 id="持効性注射剤"><span id=".E6.8C.81.E5.8A.B9.E6.80.A7.E6.B3.A8.E5.B0.84.E5.89.A4"></span>持効性注射剤</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4&action=edit&section=7" title="節を編集: 持効性注射剤"><span>編集</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/%E3%83%AA%E3%82%B9%E3%83%91%E3%83%80%E3%83%BC%E3%83%AB%E3%83%BB%E3%82%B3%E3%83%B3%E3%82%B9%E3%82%BF" title="リスパダール・コンスタ">リスパダール・コンスタ</a>：<a href="/wiki/%E3%83%AA%E3%82%B9%E3%83%9A%E3%83%AA%E3%83%89%E3%83%B3" title="リスペリドン">リスペリドン</a>の持効性注射剤。2週間持続。</li> <li>エビリファイメンテナ：<a href="/wiki/%E3%82%A2%E3%83%AA%E3%83%94%E3%83%97%E3%83%A9%E3%82%BE%E3%83%BC%E3%83%AB" title="アリピプラゾール">アリピプラゾール</a>の持効性注射剤。4週間持続。</li> <li>ゼプリオン：<a href="/wiki/%E3%83%91%E3%83%AA%E3%83%9A%E3%83%AA%E3%83%89%E3%83%B3" title="パリペリドン">パリペリドン</a>の持効性注射剤。4週間持続。</li> <li>ゼプリオンTRI：パリペリドンの持効性注射剤。12週間持続。</li> <li>ハロマンス：<a href="/wiki/%E3%83%8F%E3%83%AD%E3%83%9A%E3%83%AA%E3%83%89%E3%83%BC%E3%83%AB" title="ハロペリドール">ハロペリドール</a>の持効性注射剤。4週間持続。</li> <li>フルデカシン：<a href="/wiki/%E3%83%95%E3%83%AB%E3%83%95%E3%82%A7%E3%83%8A%E3%82%B8%E3%83%B3" title="フルフェナジン">フルフェナジン</a>の持効性注射剤。4週間持続。</li> <li><a href="/wiki/%E3%82%B4%E3%82%BB%E3%83%AC%E3%83%AA%E3%83%B3" title="ゴセレリン">ゴセレリン</a>：<a href="/wiki/%E6%80%A7%E8%85%BA%E5%88%BA%E6%BF%80%E3%83%9B%E3%83%AB%E3%83%A2%E3%83%B3%E6%94%BE%E5%87%BA%E3%83%9B%E3%83%AB%E3%83%A2%E3%83%B3" title="性腺刺激ホルモン放出ホルモン">性腺刺激ホルモン放出ホルモン</a>作動薬（GnRH作動薬）。1か月製剤と3か月製剤がある。</li></ul> <div class="mw-heading mw-heading2"><h2 id="出典"><span id=".E5.87.BA.E5.85.B8"></span>出典</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4&action=edit&section=8" title="節を編集: 出典"><span>編集</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="reflist" style="list-style-type: decimal;"> <ol class="references"> <li id="cite_note-guideline2022-1">^ <a href="#cite_ref-guideline2022_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-guideline2022_1-1"><sup><i><b>b</b></i></sup></a> <span class="reference-text">「統合失調症薬物治療ガイドライン2022」P55-P57 医学書院 2022年6月13日発行 <a href="/wiki/%E7%89%B9%E5%88%A5:%E6%96%87%E7%8C%AE%E8%B3%87%E6%96%99/9784260049870" class="internal mw-magiclink-isbn">ISBN 978-4260049870</a></span> </li> <li id="cite_note-2"><b><a href="#cite_ref-2">^</a></b> <span class="reference-text"><cite class="citation web" style="font-style:normal">“<a rel="nofollow" class="external text" href="https://answers.ten-navi.com/dictionary/cat04/3371/?utm_source=chatgpt.com">デポ剤（持効性注射剤）とは | 製薬業界用語辞典 | Answers（アンサーズ）</a>”. <i>製薬業界の転職サイト Answers(アンサーズ)</i>.  株式会社クイック. <span title="">2024年11月21日</span>閲覧。</cite></span> </li> <li id="cite_note-Persistent_Barriers_to_the_Use_of_L-3">^ <a href="#cite_ref-Persistent_Barriers_to_the_Use_of_L_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Persistent_Barriers_to_the_Use_of_L_3-1"><sup><i><b>b</b></i></sup></a> <span class="reference-text"><cite style="font-style:normal" class="citation journal">Lindenmayer, Jean-Pierre; Glick, Ira D.; Talreja, Hiteshkumar; Underriner, Michael (July 2020). “Persistent Barriers to the Use of Long-Acting Injectable Antipsychotics for the Treatment of Schizophrenia”. <i>Journal of Clinical Psychopharmacology</i> <b>40</b> (4): 346–349. <a href="/wiki/Doi_(%E8%AD%98%E5%88%A5%E5%AD%90)" class="mw-redirect" title="Doi (識別子)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FJCP.0000000000001225">10.1097/JCP.0000000000001225</a>. <style data-mw-deduplicate="TemplateStyles:r101121245">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation.cs-ja1 q,.mw-parser-output .citation.cs-ja2 q{quotes:"「""」""『""』"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free a,.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited a,.mw-parser-output .id-lock-registration a,.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription a,.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:var(--color-success,#3a3);margin-left:0.3em}.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}</style><a href="/wiki/PMID_(%E8%AD%98%E5%88%A5%E5%AD%90)" class="mw-redirect" title="PMID (識別子)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/32639287/">32639287</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Persistent+Barriers+to+the+Use+of+Long-Acting+Injectable+Antipsychotics+for+the+Treatment+of+Schizophrenia&rft.jtitle=Journal+of+Clinical+Psychopharmacology&rft.aulast=Lindenmayer&rft.aufirst=Jean-Pierre&rft.au=Lindenmayer%2C%26%2332%3BJean-Pierre&rft.au=Glick%2C%26%2332%3BIra+D.&rft.au=Talreja%2C%26%2332%3BHiteshkumar&rft.au=Underriner%2C%26%2332%3BMichael&rft.date=July+2020&rft.volume=40&rft.issue=4&rft.pages=346%E2%80%93349&rft_id=info:doi/10.1097%2FJCP.0000000000001225&rft_id=info:pmid/32639287&rfr_id=info:sid/ja.wikipedia.org:%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-Kennedy_2012-4">^ <a href="#cite_ref-Kennedy_2012_4-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Kennedy_2012_4-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Kennedy_2012_4-2"><sup><i><b>c</b></i></sup></a> <span class="reference-text"><cite style="font-style:normal" class="citation journal">Kennedy, WK (2012). <a rel="nofollow" class="external text" href="https://www.mdedge.com/psychiatry/article/64796/schizophrenia-other-psychotic-disorders/when-and-how-use-long-acting">“When and how to use long-acting injectable antipsychotics”</a> (英語). <i>Current Psychiatry</i> <b>11</b> (8): 40–43<span style="display:none;">. <a rel="nofollow" class="external free" href="https://www.mdedge.com/psychiatry/article/64796/schizophrenia-other-psychotic-disorders/when-and-how-use-long-acting">https://www.mdedge.com/psychiatry/article/64796/schizophrenia-other-psychotic-disorders/when-and-how-use-long-acting</a></span>.</cite><span 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Becker, Reinhard (1 January 2019). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298133/">“Insulin depot absorption modeling and pharmacokinetic simulation with insulin glargine 300 U/mL”</a>. <i>International Journal of Clinical Pharmacology and Therapeutics</i> <b>57</b> (1): 1–10. <a href="/wiki/Doi_(%E8%AD%98%E5%88%A5%E5%AD%90)" class="mw-redirect" title="Doi (識別子)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.5414%2FCP203269">10.5414/CP203269</a>. <a href="/wiki/PMC_(%E8%AD%98%E5%88%A5%E5%AD%90)" class="mw-redirect" title="PMC (識別子)">PMC</a> <a rel="nofollow" class="external text" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6298133/">6298133</a>. <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r101121245"><a href="/wiki/PMID_(%E8%AD%98%E5%88%A5%E5%AD%90)" class="mw-redirect" title="PMID (識別子)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/30369394/">30369394</a><span style="display:none;">. <a rel="nofollow" class="external free" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298133/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298133/</a></span>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Insulin+depot+absorption+modeling+and+pharmacokinetic+simulation+with+insulin+glargine+300+U%2FmL&rft.jtitle=International+Journal+of+Clinical+Pharmacology+and+Therapeutics&rft.aulast=Lindauer&rft.aufirst=Klaus&rft.au=Lindauer%2C%26%2332%3BKlaus&rft.au=Becker%2C%26%2332%3BReinhard&rft.date=1+January+2019&rft.volume=57&rft.issue=1&rft.pages=1%E2%80%9310&rft_id=info:doi/10.5414%2FCP203269&rft_id=info:pmc/6298133&rft_id=info:pmid/30369394&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6298133%2F&rfr_id=info:sid/ja.wikipedia.org:%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-16"><b><a href="#cite_ref-16">^</a></b> <span class="reference-text"><cite style="font-style:normal" class="citation journal">Jain, Piyush K.; Karunakaran, Dipu; Friedman, Simon H. (28 January 2013). “Construction of a Photoactivated Insulin Depot”. <i>Angewandte Chemie International Edition</i> <b>52</b> (5): 1404–1409. <a href="/wiki/Doi_(%E8%AD%98%E5%88%A5%E5%AD%90)" class="mw-redirect" title="Doi (識別子)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fanie.201207264">10.1002/anie.201207264</a>. <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r101121245"><a href="/wiki/PMID_(%E8%AD%98%E5%88%A5%E5%AD%90)" class="mw-redirect" title="PMID (識別子)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/23208858/">23208858</a>.</cite><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Construction+of+a+Photoactivated+Insulin+Depot&rft.jtitle=Angewandte+Chemie+International+Edition&rft.aulast=Jain&rft.aufirst=Piyush+K.&rft.au=Jain%2C%26%2332%3BPiyush+K.&rft.au=Karunakaran%2C%26%2332%3BDipu&rft.au=Friedman%2C%26%2332%3BSimon+H.&rft.date=28+January+2013&rft.volume=52&rft.issue=5&rft.pages=1404%E2%80%931409&rft_id=info:doi/10.1002%2Fanie.201207264&rft_id=info:pmid/23208858&rfr_id=info:sid/ja.wikipedia.org:%E6%8C%81%E5%8A%B9%E6%80%A7%E6%B3%A8%E5%B0%84%E5%89%A4"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-Bosnac2015-17"><b><a href="#cite_ref-Bosnac2015_17-0">^</a></b> <span class="reference-text">Bosnac, P., & Castle, D. (2015)."Why are long-acting injectable antipsychotics still underused?"BJPsych Advances, 21(2), 98–105.DOI: 10.1192/apt.bp.114.013045 Published by: Cambridge University Press on behalf of the Royal College of Psychiatrists.</span> </li> </ol></div><div class="navbox" aria-labelledby="投与経路_(投与方法)/_剤形/_製剤" style="border-collapse:collapse;padding:3px"><table class="nowraplinks hlist hlist-hyphen mw-collapsible autocollapse navbox-inner" style="background:transparent;color:inherit;min-width:100%;border-spacing:0px;border-collapse:separate"><tbody><tr><th scope="col" class="navbox-title" colspan="3"><div style="float:left;width:6em;text-align:left"><div class="noprint plainlinks navbar hlist" style="white-space:nowrap;font-size:60%;font-weight:normal;background-color:transparent;padding:0;color:#000;;border:none;"><ul style="display:inline"><li><a href="/wiki/Template:%E5%89%A4%E5%BD%A2" title="Template:剤形"><span title="このテンプレートを表示します" 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title="キャンディ">キャンディ</a></li> <li><a href="/wiki/%E3%83%88%E3%83%AD%E3%83%BC%E3%83%81" title="トローチ">トローチ</a></li> <li><a href="/wiki/%E3%83%81%E3%83%A5%E3%83%BC%E3%82%A4%E3%83%B3%E3%82%B0%E3%82%AC%E3%83%A0" class="mw-redirect" title="チューイングガム">チューイングガム</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding:0 0.75em;"><a href="/wiki/%E6%B6%B2%E7%8A%B6" class="mw-redirect" title="液状">液状</a></th><td class="navbox-list navbox-even" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;width:auto;"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E3%83%9E%E3%82%A6%E3%82%B9%E3%82%A6%E3%82%A9%E3%83%83%E3%82%B7%E3%83%A5" class="mw-redirect" title="マウスウォッシュ">マウスウォッシュ</a></li> <li><a href="/wiki/%E6%AD%AF%E7%A3%A8%E5%89%A4" title="歯磨剤">歯磨剤</a></li> <li><a href="/wiki/%E8%BB%9F%E8%86%8F%E5%89%A4" title="軟膏剤">軟膏剤</a></li> <li>口内用スプレー</li></ul> </div></td></tr></tbody></table><div> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding:0 0.75em;"><a href="/w/index.php?title=%E5%91%BC%E5%90%B8%E5%99%A8%E6%8A%95%E4%B8%8E&action=edit&redlink=1" class="new" title="「呼吸器投与」 (存在しないページ)">呼吸器投与</a>/<br /><a href="/wiki/%E5%90%B8%E5%85%A5%E5%99%A8" title="吸入器">吸入器</a>/<br /><a href="/wiki/%E5%90%B8%E5%85%A5%E5%89%A4" title="吸入剤">吸入剤</a></th><td class="navbox-list navbox-odd" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;width:auto;"><div style="padding:0em 0.25em"> </div><table class="nowraplinks navbox-subgroup" style="min-width:100%;border-spacing:0px;border-collapse:separate"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding:0 0.75em;width:5em; white-space:normal;"><a href="/wiki/%E5%9B%BA%E5%BD%A2" class="mw-redirect" title="固形">固形</a></th><td class="navbox-list navbox-odd" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;width:auto;"><div style="padding:0em 0.25em"> <ul><li><a href="/w/index.php?title=Smoking&action=edit&redlink=1" class="new" title="「Smoking」 (存在しないページ)">Smoking device</a></li> <li><a href="/w/index.php?title=%E3%83%89%E3%83%A9%E3%82%A4%E3%83%91%E3%82%A6%E3%83%80%E3%83%BC%E5%90%B8%E5%85%A5%E5%99%A8&action=edit&redlink=1" class="new" title="「ドライパウダー吸入器」 (存在しないページ)">ドライパウダー吸入器(DPI)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding:0 0.75em;width:5em; white-space:normal;"><a href="/wiki/%E6%B6%B2%E7%8A%B6" class="mw-redirect" title="液状">液状</a></th><td class="navbox-list navbox-even" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;width:auto;"><div style="padding:0em 0.25em"> <ul><li><a href="/w/index.php?title=%E5%8A%A0%E5%9C%A7%E5%99%B4%E9%9C%A7%E5%BC%8F%E5%AE%9A%E9%87%8F%E5%90%B8%E5%85%A5%E5%99%A8(pMDI)&action=edit&redlink=1" class="new" title="「加圧噴霧式定量吸入器(pMDI)」 (存在しないページ)">加圧噴霧式定量吸入器(pMDI)</a></li> <li><a href="/wiki/%E5%90%B8%E5%85%A5%E5%99%A8#ネブライザー" title="吸入器">ネブライザー</a></li> <li><a href="/w/index.php?title=%E3%83%B4%E3%82%A7%E3%83%9D%E3%83%A9%E3%82%A4%E3%82%B6%E3%83%BC&action=edit&redlink=1" class="new" title="「ヴェポライザー」 (存在しないページ)">ヴェポライザー</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding:0 0.75em;width:5em; white-space:normal;"><a href="/wiki/%E6%B0%97%E4%BD%93" title="気体">気体</a></th><td class="navbox-list navbox-odd" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;width:auto;"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E9%85%B8%E7%B4%A0%E3%83%9E%E3%82%B9%E3%82%AF" title="酸素マスク">酸素マスク</a></li> <li><a href="/wiki/%E9%85%B8%E7%B4%A0%E6%BF%83%E7%B8%AE%E5%99%A8" title="酸素濃縮器">酸素濃縮器</a></li> <li><a href="/wiki/%E9%BA%BB%E9%85%94%E5%99%A8" title="麻酔器">麻酔器</a></li> <li><a href="/wiki/%E7%AC%91%E6%B0%97%E5%90%B8%E5%85%A5%E9%8E%AE%E9%9D%99%E5%99%A8" title="笑気吸入鎮静器">笑気吸入鎮静器</a></li></ul> </div></td></tr></tbody></table><div> </div></td></tr></tbody></table><div> </div></td><td class="navbox-image" rowspan="7" style="width:1px;padding:0px 0px 0px 2px"><div><span typeof="mw:File"><a href="/wiki/%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB:FlattenedRoundPills.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/FlattenedRoundPills.jpg/58px-FlattenedRoundPills.jpg" decoding="async" width="58" height="44" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/FlattenedRoundPills.jpg/87px-FlattenedRoundPills.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/00/FlattenedRoundPills.jpg/116px-FlattenedRoundPills.jpg 2x" data-file-width="2048" data-file-height="1536" /></a></span><br /> <span typeof="mw:File"><a href="/wiki/%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB:Hexaaquatitanium(III)-solution.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Hexaaquatitanium%28III%29-solution.jpg/58px-Hexaaquatitanium%28III%29-solution.jpg" decoding="async" width="58" height="65" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Hexaaquatitanium%28III%29-solution.jpg/87px-Hexaaquatitanium%28III%29-solution.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Hexaaquatitanium%28III%29-solution.jpg/116px-Hexaaquatitanium%28III%29-solution.jpg 2x" data-file-width="1619" data-file-height="1816" /></a></span><br /> <span typeof="mw:File"><a href="/wiki/%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB:Inhaler.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Inhaler.jpg/58px-Inhaler.jpg" decoding="async" width="58" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Inhaler.jpg/87px-Inhaler.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Inhaler.jpg/116px-Inhaler.jpg 2x" data-file-width="1704" data-file-height="1715" /></a></span><br /> <span typeof="mw:File"><a href="/wiki/%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB:Glycerin_suppositories.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/98/Glycerin_suppositories.jpg/58px-Glycerin_suppositories.jpg" decoding="async" width="58" height="44" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/98/Glycerin_suppositories.jpg/87px-Glycerin_suppositories.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/98/Glycerin_suppositories.jpg/116px-Glycerin_suppositories.jpg 2x" data-file-width="2126" data-file-height="1623" /></a></span><br /> <span typeof="mw:File"><a href="/wiki/%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB:SPF15SunBlock.JPG" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9a/SPF15SunBlock.JPG/58px-SPF15SunBlock.JPG" decoding="async" width="58" height="80" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9a/SPF15SunBlock.JPG/87px-SPF15SunBlock.JPG 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9a/SPF15SunBlock.JPG/116px-SPF15SunBlock.JPG 2x" data-file-width="246" data-file-height="338" /></a></span><br /> <span typeof="mw:File"><a href="/wiki/%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB:Injection_Syringe_01.jpg" class="mw-file-description" title="Syringe2.jpg"><img alt="Syringe2.jpg" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Injection_Syringe_01.jpg/58px-Injection_Syringe_01.jpg" decoding="async" width="58" height="80" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Injection_Syringe_01.jpg/87px-Injection_Syringe_01.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Injection_Syringe_01.jpg/116px-Injection_Syringe_01.jpg 2x" data-file-width="1002" data-file-height="1386" /></a></span><br /> <span typeof="mw:File"><a href="/wiki/%E3%83%95%E3%82%A1%E3%82%A4%E3%83%AB:Nuvola_apps_filetypes_red.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/84/Nuvola_apps_filetypes_red.svg/52px-Nuvola_apps_filetypes_red.svg.png" decoding="async" width="52" height="38" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/84/Nuvola_apps_filetypes_red.svg/78px-Nuvola_apps_filetypes_red.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/84/Nuvola_apps_filetypes_red.svg/104px-Nuvola_apps_filetypes_red.svg.png 2x" data-file-width="121" data-file-height="89" /></a></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/%E7%9B%AE%E8%96%AC" title="目薬">点眼</a> / <a href="/wiki/%E7%82%B9%E8%80%B3%E5%89%A4" title="点耳剤">点耳</a> / <a href="/wiki/%E7%B5%8C%E9%BC%BB%E6%8A%95%E4%B8%8E" class="mw-redirect" title="経鼻投与">経鼻投与</a></th><td class="navbox-list navbox-even" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E7%82%B9%E9%BC%BB%E5%89%A4" title="点鼻剤">点鼻剤</a></li> <li><a href="/wiki/%E7%82%B9%E8%80%B3%E5%89%A4" title="点耳剤">点耳剤</a></li> <li><a href="/wiki/%E7%9B%AE%E8%96%AC" title="目薬">点眼</a></li> <li><a href="/w/index.php?title=%E7%9C%BC%E8%BB%9F%E8%86%8F%E5%89%A4&action=edit&redlink=1" class="new" title="「眼軟膏剤」 (存在しないページ)">眼軟膏剤</a></li> <li><a href="/w/index.php?title=Hydrogel&action=edit&redlink=1" class="new" title="「Hydrogel」 (存在しないページ)">Hydrogel</a></li> <li><a href="/w/index.php?title=Nanosphere&action=edit&redlink=1" class="new" title="「Nanosphere」 (存在しないページ)">Nanosphere suspension</a></li> <li><a href="/w/index.php?title=Mucoadhesion&action=edit&redlink=1" class="new" title="「Mucoadhesion」 (存在しないページ)">Mucoadhesive microdisc (microsphere tablet)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=%E6%B3%8C%E5%B0%BF%E7%94%9F%E6%AE%96%E5%99%A8&action=edit&redlink=1" class="new" title="「泌尿生殖器」 (存在しないページ)">泌尿生殖器</a></th><td class="navbox-list navbox-odd" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E8%BB%9F%E8%86%8F%E5%89%A4" title="軟膏剤">軟膏剤</a></li> <li><a href="/wiki/%E3%83%9A%E3%83%83%E3%82%B5%E3%83%AA%E3%83%BC" title="ペッサリー">ペッサリー</a></li> <li><a href="/w/index.php?title=Vaginal_ring&action=edit&redlink=1" class="new" title="「Vaginal ring」 (存在しないページ)">Vaginal ring</a></li> <li><a href="/wiki/%E8%86%A3%E6%B4%97%E6%B5%84%E5%99%A8" title="膣洗浄器">膣洗浄器</a></li> <li><a href="/wiki/%E5%AD%90%E5%AE%AE%E5%86%85%E9%81%BF%E5%A6%8A%E5%99%A8%E5%85%B7" title="子宮内避妊器具">子宮内避妊器具 (IUD)</a></li> <li><a href="/wiki/%E7%BE%8A%E8%86%9C%E5%A4%96%E6%8A%95%E4%B8%8E" title="羊膜外投与">羊膜外投与</a></li> <li><a href="/w/index.php?title=%E8%86%80%E8%83%B1%E5%86%85%E6%B3%A8%E5%85%A5%E7%99%82%E6%B3%95&action=edit&redlink=1" class="new" title="「膀胱内注入療法」 (存在しないページ)">膀胱内注入療法</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/%E7%9B%B4%E8%85%B8" title="直腸">直腸</a> (<a href="/w/index.php?title=%E7%B5%8C%E8%85%B8&action=edit&redlink=1" class="new" title="「経腸」 (存在しないページ)">経腸</a>)</th><td class="navbox-list navbox-even" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E8%BB%9F%E8%86%8F%E5%89%A4" title="軟膏剤">軟膏剤</a></li> <li><a href="/wiki/%E5%9D%90%E5%89%A4" title="坐剤">坐剤</a></li> <li><a href="/wiki/%E6%B5%A3%E8%85%B8" title="浣腸">浣腸</a> <ul><li><a href="/wiki/%E6%BA%B6%E6%B6%B2" title="溶液">溶液</a></li> <li><a href="/w/index.php?title=Hydrogel&action=edit&redlink=1" class="new" title="「Hydrogel」 (存在しないページ)">Hydrogel</a></li></ul></li> <li><a href="/w/index.php?title=Murphy_drip&action=edit&redlink=1" class="new" title="「Murphy drip」 (存在しないページ)">Murphy drip</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/%E7%9C%9F%E7%9A%AE" title="真皮">真皮</a></th><td class="navbox-list navbox-odd" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E8%BB%9F%E8%86%8F%E5%89%A4" title="軟膏剤">軟膏剤</a></li> <li><a href="/w/index.php?title=%E3%83%AA%E3%83%8B%E3%83%A1%E3%83%B3%E3%83%88%E5%89%A4&action=edit&redlink=1" class="new" title="「リニメント剤」 (存在しないページ)">リニメント剤</a></li> <li><a href="/wiki/%E3%83%9A%E3%83%BC%E3%82%B9%E3%83%88" title="ペースト">ペースト</a></li> <li><a href="/w/index.php?title=Thin_film_drug_delivery&action=edit&redlink=1" class="new" title="「Thin film drug delivery」 (存在しないページ)">Film</a></li> <li><a href="/w/index.php?title=Hydrogel&action=edit&redlink=1" class="new" title="「Hydrogel」 (存在しないページ)">Hydrogel</a></li> <li><a href="/wiki/%E3%83%AA%E3%83%9D%E3%82%BD%E3%83%BC%E3%83%A0" title="リポソーム">リポソーム</a></li> <li><a href="/w/index.php?title=Transfersome&action=edit&redlink=1" class="new" title="「Transfersome」 (存在しないページ)">Transfersome vesicals</a></li> <li>クリーム</li> <li><a href="/wiki/%E3%83%AD%E3%83%BC%E3%82%B7%E3%83%A7%E3%83%B3%E5%89%A4" class="mw-redirect" title="ローション剤">ローション剤</a></li> <li><a href="/wiki/%E3%83%AA%E3%83%83%E3%83%97%E3%82%AF%E3%83%AA%E3%83%BC%E3%83%A0" title="リップクリーム">リップクリーム</a></li> <li><a href="/wiki/%E3%82%B7%E3%83%A3%E3%83%B3%E3%83%97%E3%83%BC" title="シャンプー">シャンプー</a></li> <li><a href="/w/index.php?title=%E8%B2%BC%E4%BB%98%E8%96%AC&action=edit&redlink=1" class="new" title="「貼付薬」 (存在しないページ)">貼付薬</a></li> <li><a href="/wiki/%E7%B5%8C%E7%9A%AE%E5%90%B8%E5%8F%8E%E3%83%91%E3%83%83%E3%83%81" title="経皮吸収パッチ">経皮吸収パッチ</a></li> <li><a href="/w/index.php?title=Metered_dose_transdermal_spray&action=edit&redlink=1" class="new" title="「Metered dose transdermal spray」 (存在しないページ)">Transdermal spray</a></li> <li><span title="リンク先の項目はまだありません。新規の執筆や他言語版からの翻訳が望まれます。"><a href="/w/index.php?title=%E3%82%B8%E3%82%A7%E3%83%83%E3%83%88%E6%B3%A8%E5%B0%84%E5%99%A8&action=edit&redlink=1" class="new" title="「ジェット注射器」 (存在しないページ)">ジェット注射器</a><span style="font-size: 0.77em; font-weight: normal;" class="noprint">（<a href="https://en.wikipedia.org/wiki/Jet_injector" class="extiw" title="en:Jet injector">英語版</a>）</span></span></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/%E6%B3%A8%E5%B0%84" title="注射">注射</a> / <a href="/wiki/%E7%82%B9%E6%BB%B4" class="mw-redirect" title="点滴">点滴</a><br /> <i>(into tissue/blood)</i></th><td class="navbox-list navbox-even" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"> </div><table class="nowraplinks navbox-subgroup" style="min-width:100%;border-spacing:0px;border-collapse:separate"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding:0 0.75em;"><a href="/wiki/%E7%9A%AE%E8%86%9A" title="皮膚">皮膚</a></th><td class="navbox-list navbox-odd" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;width:auto;"><div style="padding:0em 0.25em"> <ul><li><a href="/wiki/%E6%B3%A8%E5%B0%84" title="注射">注射</a></li> <li><a href="/wiki/%E7%9A%AE%E4%B8%8B%E6%B3%A8%E5%B0%84" class="mw-redirect" title="皮下注射">皮下注射</a></li> <li><a href="/w/index.php?title=%E7%B5%8C%E7%9A%AE%E3%82%A4%E3%83%B3%E3%83%97%E3%83%A9%E3%83%B3%E3%83%88&action=edit&redlink=1" class="new" title="「経皮インプラント」 (存在しないページ)">経皮インプラント</a></li> <li><a class="mw-selflink selflink">持効性注射剤</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding:0 0.75em;"><a href="/wiki/%E8%87%93%E5%99%A8" class="mw-redirect" title="臓器">臓器</a></th><td class="navbox-list navbox-even" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px;width:auto;"><div style="padding:0em 0.25em"> <ul><li><a href="https://en.wikipedia.org/wiki/Intracavernous_injection" class="extiw" title="en:Intracavernous injection">en:Intracavernous</a></li> <li><a href="https://en.wikipedia.org/wiki/Intravitreal" class="extiw" title="en:Intravitreal">en:Intravitreal</a></li> <li><a href="https://en.wikipedia.org/wiki/Transscleral" class="extiw" title="en:Transscleral">en:Transscleral</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding:0 0.75em;"><a href="/wiki/%E4%B8%AD%E6%9E%A2%E7%A5%9E%E7%B5%8C%E7%B3%BB" title="中枢神経系">中枢神経系</a></th><td class="navbox-list navbox-odd" 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