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as a Method * define function as object methods * @type {Object} */ window.digitalData = { user: {}, page: {}, merchandising: {}, getQueryParam : function (param) { var index, key, value, hash; var hashes = window.location.href.slice(window.location.href.indexOf('?') + 1).split('&'); for (index = 0; index < hashes.length; index++) { hash = hashes[index].split('='); key = hash[0]; value = hash[1]; if (key.toUpperCase() === param.toUpperCase()) return value; } return ''; }, getValOnce: function (value, cookieName, expiry, timeUnit) { var currentDate = new Date; var currentCookieValue; // timeUnit of 'm' is minutes represented in milliseconds // thus 86400000 = 24 hours = 1 day var interval = timeUnit == 'm' ? 60000 : 86400000; cookieName = cookieName ? cookieName : 'digitaldata_gvo'; value = value ? value : ''; expiry = expiry ? expiry : 0; currentCookieValue = this.getCookie(cookieName); if (value) { currentDate.setTime(currentDate.getTime() + expiry * interval); this.setCookie(cookieName, value, expiry == 0 ? 0 : currentDate); } return value == currentCookieValue ? '' : value; }, getCookie: function (key) { var result = ""; var cookies = document.cookie ? document.cookie.split('; ') : []; for (var i = 0; i < cookies.length; i++) { var parts = cookies[i].split('='); var name = decodeURIComponent(parts.shift()); var cookie = parts ? parts.join('=') : []; // Prevent storing or parsing of a cookie that we couldn't decode. if (cookie && key === name) { // removes surrounding quotes if (cookie.indexOf('"') === 0) { // This is a quoted cookie as according to RFC2068, unescape... cookie = cookie.slice(1, -1).replace(/\\"/g, '"').replace(/\\\\/g, '\\'); } // parse utf8 characters try { cookie = decodeURIComponent(cookie); } catch (e) {} result = cookie; // we found it, don't bother looking at other cookies break; } } return result; }, setCookie : function(name, value, numDays){ if ( !numDays ) numDays = 31; var expires = new Date(); expires.setTime(expires.getTime() + (1000 * 60 * 60 * 24 * numDays)); document.cookie = name+ '=' + escape(value) + '; path=/; expires=' + expires.toGMTString() + '; domain=.' + this.getMasterDomain() + ';'; }, /** * get the master domain based on business rules */ getMasterDomain : function () { // default the master domain var masterDomain = 'thermofisher.com'; // check for alternate domain portion of URL var regexMatch = document.location.hostname.match(/\.(thermofisher)\.(cn)/i); if (regexMatch !== null) { masterDomain = regexMatch[1] + '.' + regexMatch[2]; } return masterDomain; }, /** * Check if init has been initiated once * @type {Boolean} */ initted: false, /** * @return {Array} method returns an array of a given object's key properties */ init: function () { this.page.country = this.getCookie("CK_ISO_CODE") || 'us'; this.page.language = this.getCookie('CK_LANG_CODE') || 'en'; this.page.siteName = 'thermo'; //hard coded this.initMerchandisingData(); this.initUserData(); this.displayDigitalData(); this.formSubmitEvent(); }, //specific function to set type of the page // need specific function to keep page type separate from other page attributes setPageType: function (type) { this.setPageAttribute('type', type); }, // generic function to set page attributes setPageAttribute: function (key, value) { this.page[key] = value; }, // display digitalData object displayDigitalData: function () { }, // specific function to add an object to digitalData addDigitDataObject: function (key, object) { this[key] = object; }, addChildObjectAttribute: function(child, key, value){ this[child][key] = value; }, initUserData: function(){ var gigyaCookie = this.getCookie("identity_uid"); this.user.gigyaId = ""; this.user.loginStatus = "anonymous"; if( gigyaCookie != ""){ this.user.gigyaId = gigyaCookie; this.user.loginStatus = "logged in"; } }, /** * Check if init has been initiated once * @type {Boolean} */ merchandisingDataInitted: false, initMerchandisingData: function () { // read cid and icid value from session cookie this.merchandising.icid = this.getCookie('s_ev21_tc'); this.merchandising.cid = this.getCookie('s_cmp_tc'); // EMID value this.merchandising.emid = this.getQueryParam("emid"); // referrer by domain if (typeof document.referrer !== 'undefined' && document.referrer.length > 0) { var masterDomain = this.getMasterDomain(); var refReg = document.referrer; var referrerDomain = refReg.match(/:\/\/([^/]+)\//); if (referrerDomain !== null && referrerDomain[1].indexOf(masterDomain) == -1) { this.merchandising.referrer = referrerDomain; } } document.addEventListener('registerMerchandisingData', function (event) { for (var key in event.detail) { console.log("Listener data copied", key, event.detail[key] ); digitalData.merchandising[key] = event.detail[key]; } // Map some analytics attributes to merchandising session attributes digitalData.merchandising.sessionId = digitalData.merchandising.analyticsVisitorID; digitalData.merchandising.s_vi_low = digitalData.merchandising.analyticsVisitorIDLow; digitalData.merchandising.s_vi_high = digitalData.merchandising.analyticsVisitorIDHigh; console.log("digitalData: Captured registerMerchandisingData event"); digitalData.merchandisingDataInitted = true; // Call emailCampaignRecord if the digitalDataAnalyticsListener object is loaded if (typeof digitalDataAnalyticsListener != "undefined") { console.log("digitalData: Calling email campaign record"); digitalDataAnalyticsListener.emailCampaignRecord(); } }); }, formSubmitEvent: function () { var formId = this.getQueryParam("form-submit-id"); if ((formId) && formId !== "" && formId !== null) { var eventDetail = { detail: { form: { id: formId } } }; var formSubmitEvent = new CustomEvent('formSubmit', eventDetail); console.log('form submit event started'); document.dispatchEvent(formSubmitEvent); console.log('form submit event fired', eventDetail); //flush grepToken from Session Storage sessionStorage.removeItem('grepTokenSO'); } }, modalVideoEvent: function (videoId) { if (((videoId) && videoId !== "" && videoId !== null)) { var eventDetail = { detail: { video: { playerId: videoId } } }; var modalVideoEvent = new CustomEvent('videoPlayerLoaded', eventDetail); document.dispatchEvent(modalVideoEvent); } }, customClickEvent: function (clickDetail) { if (((clickDetail) && clickDetail !== "" && clickDetail !== null)) { var eventDetail = { detail: { CustomLink: { linkName: clickDetail } } } var customClickEvent = new CustomEvent('customLinkClicks', eventDetail); document.dispatchEvent(customClickEvent); } } } })(); window.digitalData.init(); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_25"); </script> <script type="text/javascript"> var localizedStrings = { "ACCEPTANCE": "Acceptance of Terms of Use", "BTN_AGREE": "Agree", "BTN_DISAGREE": "Disagree", "PROCESSING_MESSAGE" :"processing ... please wait ...", "ADD_TO_CART_QUANTITY_ERROR":"You must provide a quantity to add an item to the cart", "ADD_TO_CART_VALID_QUANTITY_ERROR":"You must provide a valid quantity to add an item to the cart", "VIEW_CART" :"View cart & checkout", "VIEW_CONTACT_DETAIL" :"View Contact Details", "ADD_TO_CART_NOTIFICATION":"Add to Cart Notification", "UPDATE_CART" :"Update Cart", "PRINCIPAL_INVESTIGATOR":"Principal Investigator", "PRINCIPAL_INVESTIGATOR_TEAM_LEADER":"Principal Investigator or Team Leader", "PRINCIPAL_INVESTIGATOR_CHIEF":"Principal Investigator or Chief", "EMAIL_ERROR_1" :"Please Provide Collegues Email", "EMAIL_ERROR_2" :"Please enter a valid colleague email address", "EMAIL_ERROR_3" :"Please Provide Your Email", "EMAIL_ERROR_4" :"Please enter a valid email address", "ERROR_OCCURED_MESSAGE" :"The following errors occured", "NEXT" :"Next", "PREVIOUS" :"Prev", "IMAGE" :"Image", "SAVE_TO_LIST_ERROR_1" :"Please enter a list name.", "SAVE_TO_LIST_ERROR_2" :"Please enter a different list name that does not include the following: ?,/,\\,%,^,!", "MINICART_ERROR_1" :"Unable to connect to eCommerce system. 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class="details-hero" onclick="window.THERMO_FISHER.pdp.inp.toggleImagesAdvVerificationPublishedFigures(event, this)"> <a class="link published-link animated-scroll " href="#image-gallery" onclick="window.THERMO_FISHER.pdp.inp.publishedFiguresHero(event, this)"> <svg class="svg-icon published-figures-icon"> <use href="#icon-published-figures"></use> </svg> 98 Published Figures </a> </div> <div class="details-hero"> <a class="link references-link animated-scroll " href="#references-component-id" onclick="window.THERMO_FISHER.pdp.inp.referencesHero(event, this)"> <svg class="svg-icon references-icon"> <use href="#icon-references"></use> </svg> 299 References </a> </div> <div class="details-hero"> <a class="btn hero-btn hero-view-other" href="/antibody/primary/target/cd44"> View all (235) CD44 antibodies </a> </div> </div> <div class="links-ab to-show-links-in-sm"> <div class="container"> <div class="link-container"> <a class="link-antibody" href="/order/genome-database/dataSheetPdf?producttype=antibody&productsubtype=antibody_primary&productId=17-0441-82&version=Local" target="_blank" rel="nofollow"> <span> <svg class="svg-icon data-sheet-icon"> <use href="#icon-data-sheet"></use> </svg> </span> Datasheet </a> </div> <div class="link-container"> <a href="https://www.thermofisher.com/global/en/home/life-science/antibodies/antibodies-learning-center/antibody-protocols.html?icid=antibody-pdp-protocols" target="_blank" class="link-antibody"> <span> <svg class="svg-icon protocols-icon"> <use href="#icon-protocols"></use> </svg> </span> Protocols </a> </div> <div class="link-container"> <a href="/us/en/home/technical-resources/contact-us.17-0441-82.html?supportType=TS" class="link-antibody"> <span> <svg class="svg-icon tech-support-icon"> <use href="#icon-tech-support"></use> </svg> </span> Tech Support </a> </div> </div> </div> <div class="cmrc-card-cnt" id="antibody_primary"> <div class="price-card-alignmnet" 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17-0441-82, RRID AB_469390.</textarea> </div> <div class="modal-footer">  <button type="button" class="well-red btn btn-danger pull-left" data-dismiss="modal" onclick="copyToClipboard();" > Click to Copy </button>  </div> </div> </div> <script type="application/ld+json"> { "@context": "https://schema.org/", "@type": "BreadcrumbList", "itemListElement": [{ "@type": "ListItem", "position": 1, "name": "Home", "item":"https://www.thermofisher.com" },{ "@type": "ListItem", "position": 2, "name": "Antibodies", "item": "https://www.thermofisher.com/us/en/home/life-science/antibodies.html" },{ "@type": "ListItem", "position": 3, "name": "CD44", "item": "https://www.thermofisher.com/antibody/primary/target/cd44" }] } </script> </div> <div class="links-ab to-hide-links-in-sm"> <div class="container"> <div class="link-container"> <a class="link-antibody" href="/order/genome-database/dataSheetPdf?producttype=antibody&productsubtype=antibody_primary&productId=17-0441-82&version=Local" 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product-link-value="originalProductLinkValue"></div> <div class="gal-cntr container" tfs-media-gallery sku="'17-0441-82'" media-items="{'Antibody Testing Data':[{'sku':'17-0441-82','imageId':'121365','imageUrl':'https://www.thermofisher.com/antibody/images/650/17-0441-82-CD44-Flow-20170216130641.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/17-0441-82-CD44-Flow-20170216130641.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/17-0441-82-CD44-Flow-20170216130641.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/17-0441-82-CD44-Flow-20170216130641.jpg?time\u003d20240507','sortOrder':'1','description':'Staining of C57BL/6 splenocytes with staining buffer (autofluorescence) (open histogram) or 0.03 µg of Anti-Human/Mouse CD44 APC (filled histogram). Total viable cells were used for analysis.','shortDescription':'Staining of C57BL/6 splenocytes with staining buffer (autofluorescence) (open histogram) or 0.03 µg of Anti-Human/Mouse CD44 APC (filled histogram). Total viable cells were used for analysis.','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','appName':'Flow Cytometry','type':'Antibody Testing Data','journalText':'','sourceType':'1','benchsci':false,'imageName':'17-0441-82-CD44-Flow-20170216130641.jpg','benchSciPubmedId':'0'}],'Published Figures':[{'sku':'17-0441-82','imageId':'1018238','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15033_13058_2018_944_Fig5_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15033_13058_2018_944_Fig5_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15033_13058_2018_944_Fig5_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15033_13058_2018_944_Fig5_HTML.jpg?time\u003d20240507','sortOrder':'2','description':'The cancer stem cell (CSC)-like characteristics of tumor cells isolated from the secondary enhanced green fluorescent protein (EGFP) + MCF7/HRE-EGFP xenografts. a Generation of secondary MCF7/HRE-EGFP xenografts by re-implantation of sorted EGFP + and EGFP - cells isolated from the primary MCF7/HRE-EGFP xenografts. Tumor cells freshly isolated from the secondary xenografts were sorted into EGFP + and EGFP - populations for ( b ) fluorescence-activated cell sorting (FACS) analysis of the CD44 + /CD24 + and CD44 + populations ( n \u003d 5 for EGFP + cells, n \u003d 4 for EGFP - cells; *** p \u003c 0.001, Student\u0026apos;s t test). c Side population (SP) of the secondary xenograft-derived tumor cells. MCF7 tumor cells were isolated from the secondary xenografts derived from EGFP + and EGFP - tumor cells, respectively, and expanded in vitro for three passages. Cells were stained with Hoechst 33342 for side population analysis by FACS. Verapamil (50 muM) was used to block nuclear export of Hoechst 33342. These results were validated in two independent experiments. d Clonogenic potential of the freshly sorted EGFP + and EGFP - populations from the secondary xenografts ( n \u003d 6; **** p \u003c 0.0001, *** p \u003c 0.001, Student\u0026apos;s t test)','shortDescription':'The cancer stem cell (CSC)-like characteristics of tumor cells isolated from the secondary enhanced green fluorescent protein (EGFP) + MCF7/HRE-EGFP xenografts. a Generation of secondary MCF7/HRE-EGFP xenografts by re-implantation of sorted EGFP + and EGFP - cells isolated from the primary MCF7/HRE-EGFP xenografts. Tumor cells freshly isolated from the secondary xenografts were sorted into EGFP + and EGFP -... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Mar 6, 2018, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Breast cancer research : BCR','journalText':'Breast cancer research : BCR 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15033_13058_2018_944_Fig5_HTML.jpg','benchSciPubmedId':'29510720'},{'sku':'17-0441-82','imageId':'1139710','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_29140_13287_2023_3411_MOESM2_ESM.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_29140_13287_2023_3411_MOESM2_ESM.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_29140_13287_2023_3411_MOESM2_ESM.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_29140_13287_2023_3411_MOESM2_ESM.jpg?time\u003d20240507','sortOrder':'3','description':'Additional file 2: Figure S1. Characterization of ACSCs. a After 7 days of culturing, fibroblast-like cells migrate out from cartilage chips. b The result of ACSCs morphology at passage 4 and passage 8. c Flow cytometry staining demonstrated that negative express the hematopoietic and endothelial markers (CD45, CD31 and CD235A), and were positive for MSC markers (such as CD29, CD44, CD90, CD105 and PDPN) (Fig. S1c). The Scale bars represent 200mum (Fig. S1a, S1b), respectively. Experiments were repeated independently for more than three times. All data are shown as the mean +- S.D.','shortDescription':'Additional file 2: Figure S1. Characterization of ACSCs. a After 7 days of culturing, fibroblast-like cells migrate out from cartilage chips. b The result of ACSCs morphology at passage 4 and passage 8. c Flow cytometry staining demonstrated that negative express the hematopoietic and endothelial markers (CD45, CD31 and CD235A), and were positive for MSC markers (such as CD29, CD44, CD90, CD105 and PDPN) (F... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Sep 27, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Stem cell research \u0026 therapy','journalText':'Stem cell research \u0026 therapy 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29140_13287_2023_3411_MOESM2_ESM.jpg','benchSciPubmedId':'37752608'},{'sku':'17-0441-82','imageId':'1139709','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_29067_41586_2023_6436_Fig10_ESM.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_29067_41586_2023_6436_Fig10_ESM.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_29067_41586_2023_6436_Fig10_ESM.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_29067_41586_2023_6436_Fig10_ESM.jpg?time\u003d20240507','sortOrder':'4','description':'Extended Data Fig. 5 Validation of PF4-mediated changes to spleen-derived immune cells in aged mice. (a-c) Flow cytometry gating strategy for the identification of CD45+ myeloid (lin-) and lymphoid (lin+) cells, neutrophils (CD45+, lin-, Ly6G+), and macrophages (CD45+, lin-, F4/80+, CD11b+) in the aged spleen. (b) Comparison of the ratio of myeloid cells to lymphoid cells in the spleen of saline and PF4 treated aged mice (n \u003d 8 saline; 9 PF4 mice). (c) Comparison of the relative populations of neutrophils and macrophages in the spleen (n \u003d 8 saline; 9 PF4 mice). (d) qPCR of inflammation-related genes relative to Gapdh in the aged spleen (n \u003d 12 saline; 11 PF4 mice). (e-f) Flow cytometry gating strategy for the identification of CD4+ T cells, CD8+ T cells, and CD8+ T effector memory cells (CD45+, CD3+, CD8+, CD44 HI , CD62L LO) in the aged spleen. (f) Comparison of the relative populations of T cells in the spleen (n \u003d 8 mice/group). (g) Schematic of aged T cell isolation, activation, and treatment with vehicle or PF4 (1 mug mL -1). (h,i) Flow cytometry gating strategy for the identification of the exhaustion marker PD1 in CD4+ and CD8+ T cells following in vitro activation of aged T cells. (i) Quantification of PD-1 expression in CD4+ and CD8+ T cells by flow cytometry (n \u003d 6 biologically independent samples/group). Data shown as mean +- s.e.m. ; two-tailed unpaired t -test (b,c,d,f), two-way ANOVA with a Sidak post hoc test (i). Source data','shortDescription':'Extended Data Fig. 5 Validation of PF4-mediated changes to spleen-derived immune cells in aged mice. (a-c) Flow cytometry gating strategy for the identification of CD45+ myeloid (lin-) and lymphoid (lin+) cells, neutrophils (CD45+, lin-, Ly6G+), and macrophages (CD45+, lin-, F4/80+, CD11b+) in the aged spleen. (b) Comparison of the ratio of myeloid cells to lymphoid cells in the spleen of saline and PF4 tre... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature','journalText':'Nature 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29067_41586_2023_6436_Fig10_ESM.jpg','benchSciPubmedId':'37587343'},{'sku':'17-0441-82','imageId':'1139708','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_29159_nihms-1898012-f0005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_29159_nihms-1898012-f0005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_29159_nihms-1898012-f0005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_29159_nihms-1898012-f0005.jpg?time\u003d20240507','sortOrder':'5','description':'Figure 4. QFL T cells upregulate effector markers CD44 and KLRG1 in MCMV-infected mice (A and B) WT mice were uninfected, ERAAP KO immunized, or MCMV infected (1e6 PFU). QFL T cells were enriched from the spleen of each mouse, and CD44 and KLRG1 expression was analyzed. (A) Representative flow cytometry plots for CD44 expression in QFL T cells. (B) Compiled data of percentage of CD44 + QFL T cells for each group. Data are shown as mean +- SEM. (C) Representative flow cytometry plots for KLRG1 expression in QFL T cells. (D) Compiled data of percentage of KLRG1 + QFL T cells for each group. Data from (B) and (C) were pooled over two independent experiments, with 1-3 samples for each condition per experiment, and are shown as mean +- SEM. Comparisons between groups were made using an ordinary one-way ANOVA multiple comparisons test, *p \u003c 0.0332, **p \u003c 0.0021, ***p \u003c 0.0002, ****p \u003c 0.0001.','shortDescription':'Figure 4. QFL T cells upregulate effector markers CD44 and KLRG1 in MCMV-infected mice (A and B) WT mice were uninfected, ERAAP KO immunized, or MCMV infected (1e6 PFU). QFL T cells were enriched from the spleen of each mouse, and CD44 and KLRG1 expression was analyzed. (A) Representative flow cytometry plots for CD44 expression in QFL T cells. (B) Compiled data of percentage of CD44 + QFL T cells for each ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Apr 25, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell reports','journalText':'Cell reports 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29159_nihms-1898012-f0005.jpg','benchSciPubmedId':'36995940'},{'sku':'17-0441-82','imageId':'1133404','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_29154_NRR-18-1841-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_29154_NRR-18-1841-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_29154_NRR-18-1841-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_29154_NRR-18-1841-g004.jpg?time\u003d20240507','sortOrder':'6','description':'Identification of ADSCs. (A) ADSCs exhibited characteristic spindle-like morphology, as indicated by red arrows. The mesenchymal markers CD34 (B), CD44 (C), CD90 (D), CD105 (E) and the negative control marker HLA-DR (F) were used to analyze the cells by flow cytometry. The indicated markers are presented as solid red peaks, and the isotype controls are presented as solid blue peaks. The experiment was independently repeated three times. ADSCs: Adipose-derived stem cells.','shortDescription':'Identification of ADSCs. (A) ADSCs exhibited characteristic spindle-like morphology, as indicated by red arrows. The mesenchymal markers CD34 (B), CD44 (C), CD90 (D), CD105 (E) and the negative control marker HLA-DR (F) were used to analyze the cells by flow cytometry. The indicated markers are presented as solid red peaks, and the isotype controls are presented as solid blue peaks. The experiment was indep... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Neural regeneration research','journalText':'Neural regeneration research 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29154_NRR-18-1841-g004.jpg','benchSciPubmedId':'36751814'},{'sku':'17-0441-82','imageId':'1020204','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24774_cancers-14-06218-g003a.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24774_cancers-14-06218-g003a.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24774_cancers-14-06218-g003a.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24774_cancers-14-06218-g003a.jpg?time\u003d20240507','sortOrder':'7','description':'Knockdown of circ_RNF13 inhibits stemness and increases chemosensitivity in CRC cells. ( A ) The circ_RNF13 level in CRC cells was detected by qRT-PCR. ( B ) The protein level of DDX27 was detected by Western blot analysis. ( C ) The sphere-forming abilities of CRC cells were monitored by sphere formation assay. ( D ) The cell population of CD44 + CD133 + cells was detected by flow cytometry. ( E ) The CD44 or CD133 level in CRC cells was detected by IF staining. Red, CD44; green, CD133; blue, DAPI. Scale bar, 25 um. ( F ) The protein levels of stemness markers (CD44, CD133, SOX2, OCT4, and NANOG) were detected by Western blot analysis. ( G ) Cell viability was monitored by CCK-8 assay. ( H ) The colony-forming abilities of CRC cells were assessed by colony formation assay. ( I ) Cell apoptosis was measured by Annexin V-FITC/PI staining. Each experiment was performed at least three times independently. *, p \u003c 0.05, **, p \u003c 0.01, ***, p \u003c 0.001. Full pictures of the Western blots are presented in Figure S2 .','shortDescription':'Knockdown of circ_RNF13 inhibits stemness and increases chemosensitivity in CRC cells. ( A ) The circ_RNF13 level in CRC cells was detected by qRT-PCR. ( B ) The protein level of DDX27 was detected by Western blot analysis. ( C ) The sphere-forming abilities of CRC cells were monitored by sphere formation assay. ( D ) The cell population of CD44 + CD133 + cells was detected by flow cytometry. ( E ) The CD44... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 16, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cancers','journalText':'Cancers 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24774_cancers-14-06218-g003a.jpg','benchSciPubmedId':'36551703'},{'sku':'17-0441-82','imageId':'1020225','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24774_cancers-14-06218-g004a.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24774_cancers-14-06218-g004a.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24774_cancers-14-06218-g004a.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24774_cancers-14-06218-g004a.jpg?time\u003d20240507','sortOrder':'8','description':'Knockdown of DDX27 inhibits stemness and increases chemosensitivity in CRC cells. ( A ) The protein level of DDX27 was detected by Western blot analysis. ( B ) The sphere-forming abilities of CRC cells were monitored by sphere formation assay. ( C ) The cell population of CD44 + CD133 + cells was detected by flow cytometry. ( D ) The CD44 or CD133 level in CRC cells was detected by IF staining. Red, CD44; green, CD133; blue, DAPI. Scale bar, 25 um. ( E ) The protein levels of stemness markers (CD44, CD133, SOX2, OCT4, NANOG) were detected by Western blot analysis. ( F ) Cell viability was monitored by CCK-8 assay. ( G ) The colony-forming abilities of CRC cells were assessed by colony formation assay. ( H ) Cell apoptosis was measured by Annexin V-FITC/PI staining. Each experiment was performed at least three times independently. *, p \u003c 0.05, **, p \u003c 0.01, ***, p \u003c 0.001. Full pictures of the Western blots are presented in Figure S2 .','shortDescription':'Knockdown of DDX27 inhibits stemness and increases chemosensitivity in CRC cells. ( A ) The protein level of DDX27 was detected by Western blot analysis. ( B ) The sphere-forming abilities of CRC cells were monitored by sphere formation assay. ( C ) The cell population of CD44 + CD133 + cells was detected by flow cytometry. ( D ) The CD44 or CD133 level in CRC cells was detected by IF staining. Red, CD44; g... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 16, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cancers','journalText':'Cancers 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24774_cancers-14-06218-g004a.jpg','benchSciPubmedId':'36551703'},{'sku':'17-0441-82','imageId':'1020183','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24773_sciadv.abp8674-f3.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24773_sciadv.abp8674-f3.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24773_sciadv.abp8674-f3.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24773_sciadv.abp8674-f3.jpg?time\u003d20240507','sortOrder':'9','description':'Fig. 3. SCLC ex vivo tumors have distinct phenotypic states regulated by the epigenome. ( A ) Whole transcriptome associations in matched CCX1 primary tumor, PDX, and ex vivo cells. ( B ) Scatter star plot of gene expression [transcript per million (TPM)] for program defining genes in five matched PDX and ex vivo cells: CCX1, CCX280, CBX41, CBX163, and CBX140. Hubs \u003d means; spokes \u003d individual sample values. ( C ) Phase contrast images (x20) of CCX1 ex vivo cells. Arrows mark representative populations of cells in each stratum. ( D ) Strata profiled by immunoblot. ( E ) Flow cytometry data show CD44- and EpCAM-expressing cells in each stratum. APC, allophycocyanin; PE, phycoerythrin. ( F ) Invasion assay of strata or cells sorted via fluorescence-activated cell sorting (FACS) for CD44 or EpCAM. Values are an average of the number of stained cells from four high-power fields. Error bars represent SEM of at least three different experiments. The student t test with Welch\u0026apos;s correction was used for statistical analysis. * P \u003c 0.05. ( G ) CCX1 ex vivo cells (5 x 10 6 ) were treated with chemotherapy (EP; etoposide (1.5 mug/ml) and cisplatin (0.5 mug/ml)] for 5 days, followed by drug washout or irradiated to a total dose of 10 Gy (2 Gy per fraction daily). CD44- and EpCAM-expressing cells were quantified by flow cytometry at the indicated times, and the change in the percentage of CD44 and EpCAM (%Delta) calculated relative to t \u003d 0. ( H and I ) Cells with differential express','shortDescription':'Fig. 3. SCLC ex vivo tumors have distinct phenotypic states regulated by the epigenome. ( A ) Whole transcriptome associations in matched CCX1 primary tumor, PDX, and ex vivo cells. ( B ) Scatter star plot of gene expression [transcript per million (TPM)] for program defining genes in five matched PDX and ex vivo cells: CCX1, CCX280, CBX41, CBX163, and CBX140. Hubs \u003d means; spokes \u003d individual sample values... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 14, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Science advances','journalText':'Science advances 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24773_sciadv.abp8674-f3.jpg','benchSciPubmedId':'36516249'},{'sku':'17-0441-82','imageId':'1020162','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24772_41541_2022_560_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24772_41541_2022_560_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24772_41541_2022_560_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24772_41541_2022_560_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'10','description':'Fig. 2 AMP-CpG immunization generates long-lived memory T cell responses that rapidly expand upon antigen re-exposure in mice. C57Bl/6 J mice ( n \u003d 5) were immunized twice with 10 ug WH-01 RBD protein and 1 nmol soluble or AMP-CpG. a , b 17 weeks post dose 2, blood was collected for a pre-recall time point, followed by subcutaneous challenge with 10 ug WH-01 RBD protein on the next day, and a second blood collection 7 days later. a Pre-challenge peripheral blood leukocytes were stained for CD44 and CD62L. Shown are percentages of tetramer + CD44 + CD62L + cells among CD8 + T cells. b Peripheral blood CD8 + T cells collected before and after challenge were stained with tetramer specific for Spike RBD and analyzed by flow cytometry. c - g 30 weeks post dose 2, mice were challenged subcutaneously with 10 ug WH-01 RBD protein and assayed 7 days later. CD8 + T cells collected from blood ( c ) and perfused lung ( e ), and CD4 + T cells collected from blood ( d ) and perfused lung ( f ) were stimulated with WH-01 RBD OLPs and assayed for intracellular cytokines by flow cytometry. g Splenocytes were restimulated with WH-01 RBD OLPs and assayed for IFNgamma production by ELISpot. Mock vaccines contained AMP-CpG without the addition of antigen. Values depicted are means+-standard deviation. * p \u003c 0.05, ** p \u003c 0.01 , *** p \u003c 0.001, **** p \u003c 0.0001 by one-way ANOVA followed by Tukey\u0026apos;s post-hoc analysis applied to tetramer + or cytokine + T cell frequencies, or SFC numbers ( a - g ).','shortDescription':'Fig. 2 AMP-CpG immunization generates long-lived memory T cell responses that rapidly expand upon antigen re-exposure in mice. C57Bl/6 J mice ( n \u003d 5) were immunized twice with 10 ug WH-01 RBD protein and 1 nmol soluble or AMP-CpG. a , b 17 weeks post dose 2, blood was collected for a pre-recall time point, followed by subcutaneous challenge with 10 ug WH-01 RBD protein on the next day, and a second blood c... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 28, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'NPJ vaccines','journalText':'NPJ vaccines 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24772_41541_2022_560_Fig2_HTML.jpg','benchSciPubmedId':'36307453'},{'sku':'17-0441-82','imageId':'1020120','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24714_41598_2022_22955_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24714_41598_2022_22955_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24714_41598_2022_22955_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24714_41598_2022_22955_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'11','description':'Figure 2 ANRIL/miR-181b-5p/S1PR1 expression and T cell activation in myocardial tissues of UC mice ( A ) qRT-PCR of ANRIL expression; ( B ) qRT-PCR of miR-181b-5p expression; ( C ) qRT-PCR of S1PR1 mRNA expression; ( D ) Western blot of S1PR1 protein expression; ( E ) immunofluorescence of S1PR1 expression, scale bar \u003d 50 mum; ( F ) flow cytometry of T cell markers (CD3, CD44, and Th17A); ( G ) quantifying of cells positive for CD3, CD44, and Th17A. *P \u003c 0.05, **P \u003c 0.01, ***P \u003c 0.001 vs. control. Data was analyzed using one-way analysis of variance (ANOVA) followed by Tukey\u0026apos;s test.','shortDescription':'Figure 2 ANRIL/miR-181b-5p/S1PR1 expression and T cell activation in myocardial tissues of UC mice ( A ) qRT-PCR of ANRIL expression; ( B ) qRT-PCR of miR-181b-5p expression; ( C ) qRT-PCR of S1PR1 mRNA expression; ( D ) Western blot of S1PR1 protein expression; ( E ) immunofluorescence of S1PR1 expression, scale bar \u003d 50 mum; ( F ) flow cytometry of T cell markers (CD3, CD44, and Th17A); ( G ) quantifying ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 27, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Scientific reports','journalText':'Scientific reports 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24714_41598_2022_22955_Fig2_HTML.jpg','benchSciPubmedId':'36302829'},{'sku':'17-0441-82','imageId':'1020141','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24714_41598_2022_22955_Fig6_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24714_41598_2022_22955_Fig6_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24714_41598_2022_22955_Fig6_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24714_41598_2022_22955_Fig6_HTML.jpg?time\u003d20240507','sortOrder':'12','description':'The effects of ANRIL silencing or miR-181b-5p overexpression on pathological changes and T cell activation in UC mice ( A ) HE and Masson staining of myocardial and nephridial tissues, scale bar \u003d 20 mum; ( B ) flow cytometry of T cell markers (CD3, CD44, and Th17A); ( C ) quantifying of cells positive for CD3, CD44, and Th17A. ***P \u003c 0.001 vs. control; ## P \u003c 0.01, ### P \u003c 0.001 vs. model. Data was analyzed using t test or one-way analysis of variance (ANOVA) followed by Tukey\u0026apos;s test.','shortDescription':'The effects of ANRIL silencing or miR-181b-5p overexpression on pathological changes and T cell activation in UC mice ( A ) HE and Masson staining of myocardial and nephridial tissues, scale bar \u003d 20 mum; ( B ) flow cytometry of T cell markers (CD3, CD44, and Th17A); ( C ) quantifying of cells positive for CD3, CD44, and Th17A. ***P \u003c 0.001 vs. control; ## P \u003c 0.01, ### P \u003c 0.001 vs. model. Data was analyze... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 27, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Scientific reports','journalText':'Scientific reports 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24714_41598_2022_22955_Fig6_HTML.jpg','benchSciPubmedId':'36302829'},{'sku':'17-0441-82','imageId':'1020099','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24771_biomedicines-10-02488-g001a.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24771_biomedicines-10-02488-g001a.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24771_biomedicines-10-02488-g001a.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24771_biomedicines-10-02488-g001a.jpg?time\u003d20240507','sortOrder':'13','description':'Figure 1 CD44 expression was higher in metastatic lymph nodes, and CD44 knockdown reduced the migration and invasion abilities of breast cancer cells: ( a ) Flow cytometric analysis of CD44 expression in primary breast tumors (T) and paired metastatic lymph nodes (LN) in 14 breast cancer patients\u0026apos; samples. ( b ) The expression of CD44 in breast cancer tissues, as determined by immunohistochemistry, was assessed by the H-score. The discriminatory threshold was set at H-score \u003d 200, and existing samples were reread and classed as low (H-score \u003c 200) or high (\u003e\u003d200) CD44 expression. (left) Bar figure showing the quantification results for CD44 expression in primary tumors (T) and lymph node metastases (LN) was assessed by immunohistochemistry in 35 breast cancer patients\u0026apos; samples. Scale bar \u003d 100um. ( c ) Cell migration and invasion abilities in control and CD44 knockdown MDA-MB-231 and ZR75 cells (Luc: luciferase, KD: knockdown). ( d ) Cell migration and invasion abilities in control and CD44-overexpressing ZR75 and MCF7 cells (EV: empty vector, OE: overexpression). ( e ) Mammosphere formation ability of control, CD44 knockdown ZR75, and CD44 overexpressed ZR75 and MCF7 cells. The data are presented as mean +- SD. * Indicates p \u003c 0.05, and ** indicates p \u003c 0.01.','shortDescription':'Figure 1 CD44 expression was higher in metastatic lymph nodes, and CD44 knockdown reduced the migration and invasion abilities of breast cancer cells: ( a ) Flow cytometric analysis of CD44 expression in primary breast tumors (T) and paired metastatic lymph nodes (LN) in 14 breast cancer patients\u0026apos; samples. ( b ) The expression of CD44 in breast cancer tissues, as determined by immunohistochemistry, was... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 5, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Biomedicines','journalText':'Biomedicines 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24771_biomedicines-10-02488-g001a.jpg','benchSciPubmedId':'36289750'},{'sku':'17-0441-82','imageId':'1020078','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24769_gr7.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24769_gr7.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24769_gr7.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24769_gr7.jpg?time\u003d20240507','sortOrder':'14','description':'Immunological effect provoked by APTP NPs plus X-ray irradiation. \u0026apos;+\u0026apos; represents with X-ray irradiation, \u0026apos;-\u0026apos; represents without X-ray irradiation. a Schematic illustration of tumor therapeutic procedure in vivo. b,c Representative flow cytometry plots ( b ) and quantitative analysis c results of lymphatic derived DCs maturation (CD11c + CD80 + CD86 + , gated on CD11c + DCs) under different treatments. d,e Quantitative analysis of Ki67 + ( d ) and GzmB + ( e ) CD8 + T cells in lymph nodes after gating on CD3 + CD8 + T cells under different treatments. f-i CD8 + and CD4 + T cells after gating on CD45 + CD3 + T cells in primary and distant tumors. j,k Representative flow cytometry plots ( j ) and quantitative analysis ( k ) of effector memory T cells (CD3 + CD8 + CD44 + CD62L - , gated on CD3 + CD8 + T cells) in spleens under different treatments. l-o IFN-gamma, IL-6, IL-12p70, and TNF-alpha secretion in serum under different treatments. Data are presented as mean +- SD (n \u003d 4). One-way ANOVA analysis with Tukey\u0026apos;s multiple comparison test was used. Significance is presented as *p \u003c 0.05, **p \u003c 0.01, ***p \u003c 0.001, and ****p \u003c 0.0001. Fig. 7','shortDescription':'Immunological effect provoked by APTP NPs plus X-ray irradiation. \u0026apos;+\u0026apos; represents with X-ray irradiation, \u0026apos;-\u0026apos; represents without X-ray irradiation. a Schematic illustration of tumor therapeutic procedure in vivo. b,c Representative flow cytometry plots ( b ) and quantitative analysis c results of lymphatic derived DCs maturation (CD11c + CD80 + CD86 + , gated on CD11c + DCs) under differe... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Bioactive materials','journalText':'Bioactive materials 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24769_gr7.jpg','benchSciPubmedId':'36203954'},{'sku':'17-0441-82','imageId':'1020057','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24768_41419_2022_5262_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24768_41419_2022_5262_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24768_41419_2022_5262_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24768_41419_2022_5262_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'15','description':'Fig. 1 RNF4 is essential for OD of hBMSCs. A Western blot analysis of endogenous RNF4 and beta-catenin levels in protein extracts derived from untreated hBMSCs (Un) or cells in which OD was induced (OI) for fourteen days; B Western blot analysis of endogenous RNF4 protein levels in protein extract derived from wild-type hBMSC or hBMSCs in which RNF4 was knocked down using shRNA (sh-RNF4#1) or control scrambled shRNA (sh-Scr) with or without OI for 14 days. Actin (A) and tubulin (B) serve as a loading control. C Accumulation of calcium precipitates during OD at day zero and 21 days of OI, as evident by Alizarin Red staining (AR, red) in control (sh-Scr) or hBMSCs in which RNF4 was knocked down using sh-RNA (sh-RNF4). Brilliant-Violate staining (BV, purple) marks viable cells. D Alkaline phosphate activity upon 7, 14 days of OI of control scrambled treated hBMSCs, or hBMSCs in which RNF4 was knocked down using shRNA ( n \u003d 2 ** p \u003c 0.01; ns non-significance). E qPCR analysis of RNF4 and RUNX2 mRNA levels in control (sh-SCR) or RNF4-targeted hBMSCs (sh-RNF4). F , G FACS-assisted analysis of OD of the indicated cell surface markers at day zero and 14 days of OD. In both F and G a representative FACS analysis is shown, and Bar-graph represents three independent biological experiments. CD44 and CD90 are markers of undifferentiated hBMSCs, n \u003d 3 *** p \u003c 0.001; ** p \u003c 0.01.','shortDescription':'Fig. 1 RNF4 is essential for OD of hBMSCs. A Western blot analysis of endogenous RNF4 and beta-catenin levels in protein extracts derived from untreated hBMSCs (Un) or cells in which OD was induced (OI) for fourteen days; B Western blot analysis of endogenous RNF4 protein levels in protein extract derived from wild-type hBMSC or hBMSCs in which RNF4 was knocked down using shRNA (sh-RNF4#1) or control scramb... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Sep 24, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24768_41419_2022_5262_Fig1_HTML.jpg','benchSciPubmedId':'36153321'},{'sku':'17-0441-82','imageId':'1020036','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24767_JEM_20211688_Fig6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24767_JEM_20211688_Fig6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24767_JEM_20211688_Fig6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24767_JEM_20211688_Fig6.jpg?time\u003d20240507','sortOrder':'16','description':'Figure 6. Identifying lncEry -interacting proteins. (A) Experimental design for identifying lncEry -interacting proteins. In vitro-transcribed lncEry -3 was used as the bait, and anti- lncEry -3 was used as the control. (B and C) RNA pulldown and mass spectrometry analyses of lncEry -interacting proteins. Whole-cell extracts from MEP (B) or MEL (C) were prepared and subjected to RNA pulldown using in vitro-transcribed lncEry -3 or anti- lncEry -3 as the bait. After extensive washing, the bound proteins were eluted and visualized by silver staining on SDS-PAGE. The protein bands on the gel were recovered by trypsinization and analyzed by mass spectrometry. Detailed results from the mass spectrometric analysis are provided in Tables S4 and S5 . (D) Overlapping lncEry interaction partners from MEP and MEL cells, as analyzed by mass spectrometry. (E) RNA-pulldown-purified proteins retrieved using the indicated baits were analyzed by Western blotting with antibodies against the indicated proteins. (F and G) CFU colony assays of 2,000 cKit + cells transfected with control, Wdr82, or Ddx5 shRNAs cultured for 10-14 d in complete methylcellulose-based medium. The colony numbers are provided in G ( n \u003d 3-4 wells). Representative images from triplicate experiments are shown in F. (H) Cellular extracts of cKit + cells transfected with control, Wdr82, or Ddx5 shRNAs were prepared and analyzed by Western blotting with indicated antibodies. (I) BFU-E colony assays of 2,000 cKit + cells tran','shortDescription':'Figure 6. Identifying lncEry -interacting proteins. (A) Experimental design for identifying lncEry -interacting proteins. In vitro-transcribed lncEry -3 was used as the bait, and anti- lncEry -3 was used as the control. (B and C) RNA pulldown and mass spectrometry analyses of lncEry -interacting proteins. Whole-cell extracts from MEP (B) or MEL (C) were prepared and subjected to RNA pulldown using in vitro-... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Apr 4, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of experimental medicine','journalText':'The Journal of experimental medicine 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24767_JEM_20211688_Fig6.jpg','benchSciPubmedId':'35315911'},{'sku':'17-0441-82','imageId':'952623','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20580_urn-x-wiley-20457634-media-cam44533-cam44533-fig-0005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20580_urn-x-wiley-20457634-media-cam44533-cam44533-fig-0005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20580_urn-x-wiley-20457634-media-cam44533-cam44533-fig-0005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20580_urn-x-wiley-20457634-media-cam44533-cam44533-fig-0005.jpg?time\u003d20240507','sortOrder':'17','description':'5 FIGURE (A) FACS analysis for CD44 or Sca-1-positive subpopulations in primary #1 cells after Wnt small-molecule inhibitors for 24 h. CWP291, 1 uM CWP232291; BC21, 10 uM BC21; CCT, 20 uM CCT031374; PKF, 2 uM PKF 118-774; Cisplatin, 1 uM cisplatin. Right, representative FACS images showing reduced CD44 or Sca-1-positive cells in primary #1 cells after CWP232291 treatment. (B) Sphere-forming assay showing reduced tumorsphere formation from primary #1 cells after the treatment for 7 days with Wnt inhibitors. The spheres greater than 100 mm of diameter were enumerated. Right, representative images of tumor spheres after the treatment with Wnt inhibitors. (C) CWP232291 inhibited primary (with CWP232291) and second sphere formation (without CWP232291) in primary #1 and SW620. (D) Representative images of tumorspheres from primary #1 cells of (C). (E) Representative IF images for CD133, Lgr-5, and Sca-1, putative mouse intestinal cancer stem cell markers, in vehicle- or CWP232291-treated allografts of SCID mice. SCID mice injected with primary #1 cell were treated with 100 mg/kg CWP232291 twice a week for 8 weeks. Bottom, IF scoring for CD133, Lgr-5, and Sca-1-positive tumor cells in vehicle- ( n \u003d 3) or CWP232291-treated ( n \u003d 3) allografts. Bar \u003d 100 um. (F) FACS analysis for CD133 in CWP232291- or vehicle-treated allografts. Single cell suspensions were obtained from allografts after dispase digestion. FACS, fluorescence-activated cell sorting; IF, immunofluorescence. * p \u003c 0.05','shortDescription':'5 FIGURE (A) FACS analysis for CD44 or Sca-1-positive subpopulations in primary #1 cells after Wnt small-molecule inhibitors for 24 h. CWP291, 1 uM CWP232291; BC21, 10 uM BC21; CCT, 20 uM CCT031374; PKF, 2 uM PKF 118-774; Cisplatin, 1 uM cisplatin. Right, representative FACS images showing reduced CD44 or Sca-1-positive cells in primary #1 cells after CWP232291 treatment. (B) Sphere-forming assay showing re... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'May 1, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cancer medicine','journalText':'Cancer medicine 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20580_urn-x-wiley-20457634-media-cam44533-cam44533-fig-0005.jpg','benchSciPubmedId':'35274815'},{'sku':'17-0441-82','imageId':'1020015','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24766_coac004f2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24766_coac004f2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24766_coac004f2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24766_coac004f2.jpg?time\u003d20240507','sortOrder':'18','description':'Characterization of red panda eMSCs. ( A ) RT-PCR analysis of pluripotency genes in eMSCs. beta-actin was used as a control for RNA sample quality. ( B ) The expression of SOX2 was detected in red panda eMSCs and skin FCs by western blot. GAPDH was used as the loading control. ( C ) Red panda eMSCs were stained with phycoerythrin (PE)-conjugated CD44, CD49f, CD105, CD34 or PE-Cyanine7 conjugated CD31 antibodies. Blue areas, signal from isotype controls; red areas, signal from the specific cell surface marker; grey areas, unstained black control.','shortDescription':'Characterization of red panda eMSCs. ( A ) RT-PCR analysis of pluripotency genes in eMSCs. beta-actin was used as a control for RNA sample quality. ( B ) The expression of SOX2 was detected in red panda eMSCs and skin FCs by western blot. GAPDH was used as the loading control. ( C ) Red panda eMSCs were stained with phycoerythrin (PE)-conjugated CD44, CD49f, CD105, CD34 or PE-Cyanine7 conjugated CD31 antibo... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jan 1, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Conservation physiology','journalText':'Conservation physiology 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24766_coac004f2.jpg','benchSciPubmedId':'35211318'},{'sku':'17-0441-82','imageId':'931951','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19129_fonc-12-816894-g005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19129_fonc-12-816894-g005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19129_fonc-12-816894-g005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19129_fonc-12-816894-g005.jpg?time\u003d20240507','sortOrder':'19','description':'Figure 5 CD44 protein expression analyzed by flow cytometry. (A) CD44 regulation by ruxolitinib treatment. The CD44 expression profiles of ruxolitinib-treated myxoid liposarcoma (MLS) 402-91 cells compared with control cells treated with DMSO are shown as an example (left panel). Mean CD44 expressions in ruxolitinib-treated MLS (402-91, 2645-94, and 1765-92) and fibrosarcoma [HT1080 wild-type (WT), HT1080 EGFP, and HT1080 FUS-DDIT3-EGFP] cells are shown (right panel). **** p \u003c 0.0001, paired Student\u0027s t -test. (B) CD44 regulation by anoikis resistance. The CD44 expression profiles of anoikis-resistant MLS 402-91 cells in comparison to control cell cultures in monolayer are shown as example (left panel). Mean CD44 expressions in anoikis-resistant cells compared with control cells for MLS (402-91, 2645-94, and 1765-92) cells are shown (right panel). * p \u003c 0.05, paired Student\u0027s t -test.','shortDescription':'Figure 5 CD44 protein expression analyzed by flow cytometry. (A) CD44 regulation by ruxolitinib treatment. The CD44 expression profiles of ruxolitinib-treated myxoid liposarcoma (MLS) 402-91 cells compared with control cells treated with DMSO are shown as an example (left panel). Mean CD44 expressions in ruxolitinib-treated MLS (402-91, 2645-94, and 1765-92) and fibrosarcoma [HT1080 wild-type (WT), HT1080 E... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Feb 23, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in oncology','journalText':'Frontiers in oncology 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19129_fonc-12-816894-g005.jpg','benchSciPubmedId':'35186752'},{'sku':'17-0441-82','imageId':'952679','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20582_41467_2022_28438_Fig4_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20582_41467_2022_28438_Fig4_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20582_41467_2022_28438_Fig4_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20582_41467_2022_28438_Fig4_HTML.jpg?time\u003d20240507','sortOrder':'20','description':'Fig. 4 N2-converted neutrophils inhibit T cell proliferation, activation and Th1 differentiation. a Representative flow cytometry plots and percentage of the indicated T cell subsets in the pre-metastatic lung ( n \u003d 6 mice in each group). b CFSE-labeled CD4 + or CD8 + splenocytes were stimulated with anti-CD3/CD28 antibodies and mixed without (BLANK) or with neutrophils purified from lungs of tumor-bearing mice. The percentage of proliferating T cells is shown ( n \u003d 6 culturing experiments). c CFSE-labeled OT-1 splenocytes (CD8 + ) were mixed with OVA 257-264 -pulsed bone marrow-derived DCs and neutrophils as in panel b. The percentage of proliferating T cells is shown ( n \u003d 6 culturing experiments). d CD4 + and CD8 + T cells in the pre-metastatic lung were subjected to CD44 and CD62L staining. Representative contour plots and summary data were shown ( n \u003d 6 mice in each group). e The expression of IFN-gamma and TNF-alpha were analyzed in CD4 + and CD8 + T cells in the pre-metastatic lung ( n \u003d 6 mice in each group). f CD4 + and CD8 + T cells were purified from naive mice\u0027s spleen stimulated with anti-CD3/CD28 antibodies and mixed with the indicated neutrophils. Twenty-four hours later, the cell fraction adopting a CD44 + CD62L - phenotype was determined by flow cytometry ( n \u003d 6 culturing experiments). g Naive CD4 + T cells were stimulated under Th1-stimulating conditions in the presence of the indicated lung neutrophils. Four days later, the cells were re-stimulated with PM','shortDescription':'Fig. 4 N2-converted neutrophils inhibit T cell proliferation, activation and Th1 differentiation. a Representative flow cytometry plots and percentage of the indicated T cell subsets in the pre-metastatic lung ( n \u003d 6 mice in each group). b CFSE-labeled CD4 + or CD8 + splenocytes were stimulated with anti-CD3/CD28 antibodies and mixed without (BLANK) or with neutrophils purified from lungs of tumor-bearing ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Feb 16, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20582_41467_2022_28438_Fig4_HTML.jpg','benchSciPubmedId':'35173168'},{'sku':'17-0441-82','imageId':'931930','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19128_fonc-11-780410-g007.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19128_fonc-11-780410-g007.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19128_fonc-11-780410-g007.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19128_fonc-11-780410-g007.jpg?time\u003d20240507','sortOrder':'21','description':'Figure 7 SLC27A6 expression positively correlates with CD24 and CD44 expression level in NPC cells. (A) Positive correlation between the mRNA expression of SLC27A6 and CD24 in NPC cells (HONE1, R\u003d0.95; 5-8F, R\u003d0.99) by qRT-PCR. (B) No significant difference was shown between the SLC27A6 and CD34 mRNA expression in HONE1 (left panel), while a negative correlation was seen in 5-8F (right panel). (C) Positive correlation between the mRNA expression of SLC27A6 and CD44 in NPC cells (HONE1, R\u003d0.98; 5-8F, R\u003d0.97) by qRT-PCR. (D) The CD44 expression levels in HONE1 (left panel) and 5-8F (right panel) stably transfected cells were measured by flow cytometry. NS, no significance \u003e 0.05; * P \u003c 0.05; ** P \u003c 0.01; *** P \u003c 0.001.','shortDescription':'Figure 7 SLC27A6 expression positively correlates with CD24 and CD44 expression level in NPC cells. (A) Positive correlation between the mRNA expression of SLC27A6 and CD24 in NPC cells (HONE1, R\u003d0.95; 5-8F, R\u003d0.99) by qRT-PCR. (B) No significant difference was shown between the SLC27A6 and CD34 mRNA expression in HONE1 (left panel), while a negative correlation was seen in 5-8F (right panel). (C) Positive ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jan 21, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in oncology','journalText':'Frontiers in oncology 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19128_fonc-11-780410-g007.jpg','benchSciPubmedId':'35047398'},{'sku':'17-0441-82','imageId':'931867','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19126_41419_2021_4394_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19126_41419_2021_4394_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19126_41419_2021_4394_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19126_41419_2021_4394_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'22','description':'Fig. 2 GPR120 reduced CD4 + T cell responses in mice with liver injury. Wild-type (WT) and GPR120 -/- (GPR120 KO) mice were injected with P. acnes (P.ac). Vehicle or TUG891 (10 mg/kg) was administered i.p. to WT mice on days 0, 2, 4, and 6 after P. acnes injection. Livers and spleens were isolated on day 7 ( n \u003d 7 mice per group). a Absolute numbers of total MNCs in livers and spleens were analyzed by flow cytometry. b Percentages of CD4 + T cells in total MNCs in livers and spleens were analyzed by flow cytometry. c The expression levels of CD44 and CD62L in CD4 + T cells in the livers and spleens were analyzed by flow cytometry. d On day 6 after priming, BrdU was injected i.p. into the mice. MNCs were isolated from livers and spleens the next day. Cells were stained for CD4 and BrdU. The frequencies of CD4 + BrdU + T cells in the livers and spleens were determined by flow cytometry. e The percentages of TNF-alpha + , IFN-gamma + , and Foxp3 + cells in CD4 + T cells were assessed by intracellular staining and flow cytometry. f The levels of serum TNF-alpha, IFN-gamma, IL-4 and IL-10 were measured by enzyme-linked immunosorbent assay. The results are representative of three to six independent experiments and presented as the mean +- SEM. Significant differences were analyzed by One-way ANOVA. * p \u003c 0.05, ** p \u003c 0.01, *** p \u003c 0.001, ns no significance.','shortDescription':'Fig. 2 GPR120 reduced CD4 + T cell responses in mice with liver injury. Wild-type (WT) and GPR120 -/- (GPR120 KO) mice were injected with P. acnes (P.ac). Vehicle or TUG891 (10 mg/kg) was administered i.p. to WT mice on days 0, 2, 4, and 6 after P. acnes injection. Livers and spleens were isolated on day 7 ( n \u003d 7 mice per group). a Absolute numbers of total MNCs in livers and spleens were analyzed by flow ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 16, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19126_41419_2021_4394_Fig2_HTML.jpg','benchSciPubmedId':'34911928'},{'sku':'17-0441-82','imageId':'931888','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19126_41419_2021_4394_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19126_41419_2021_4394_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19126_41419_2021_4394_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19126_41419_2021_4394_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'23','description':'Fig. 3 GPR120 had no effects on the activation, proliferation, and differentiation of CD4 + T cells in vitro. T cells were isolated from the spleens of wild-type (WT) mice and GPR120 -/- (GPR120 KO) mice. T cells were cultured (2 x 10 5 cells/well) in the presence of anti-CD3 and anti-CD28 antibodies. T cells from WT mice were treated with DMSO, TUG891 (20 muM) with or without AH7614 (20 muM). a , b The expression levels of CD25, CD44, CD62L, and CD69 on CD4 + T cells were analyzed by flow cytometry. c , d Frequencies of the proliferating (CFSE low ) CD4 + T cell proliferation in response to the indicated treatments were measured by flow cytometry. e , f CD4 + T cells were stained for the surface marker CD4 and intracellular expression of TNF-alpha and IFN-gamma on day 5 and analyzed by flow cytometry. g , h CD4 + T cells were stained for the surface marker CD4 and intracellular expression of Foxp3 on day 5 and analyzed by flow cytometry. The results are representative of three independent experiments and presented as the mean +- SEM. Significant differences were analyzed by One-way ANOVA. ns no significance.','shortDescription':'Fig. 3 GPR120 had no effects on the activation, proliferation, and differentiation of CD4 + T cells in vitro. T cells were isolated from the spleens of wild-type (WT) mice and GPR120 -/- (GPR120 KO) mice. T cells were cultured (2 x 10 5 cells/well) in the presence of anti-CD3 and anti-CD28 antibodies. T cells from WT mice were treated with DMSO, TUG891 (20 muM) with or without AH7614 (20 muM). a , b The exp... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 16, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19126_41419_2021_4394_Fig3_HTML.jpg','benchSciPubmedId':'34911928'},{'sku':'17-0441-82','imageId':'931846','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19027_41467_2021_27485_Fig5_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19027_41467_2021_27485_Fig5_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19027_41467_2021_27485_Fig5_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19027_41467_2021_27485_Fig5_HTML.jpg?time\u003d20240507','sortOrder':'24','description':'Fig. 5 QD-Cat-RGD-based RT for promoting DC maturation and antigen presentation in TDLNs and consequently inducing T cell-driven antitumor immunity. a Representative flow cytometric analysis images and relative quantification of co-stimulatory molecules CD80 + CD86 + gating on CD45 + CD11c + cells in TDLNs. b Representative flow cytometric analysis images and relative quantification of MHC-II expression on CD11c + CD45 + cells in the TDLNs. c Representative flow cytometric analysis images and relative quantification of CD3 + T cells gating on CD45 + in tumors. d Representative immunofluorescence images of tumors showing CD8 + T cells and relative quantification of CD8 + CD3 + T cells gating on CD45 + cells in tumors by flow cytometry. Scale bars \u003d 50 mum. The immunofluorescent images were representative of those generated from three mice each group. e Representative flow cytometric analysis images and relative quantification of CD44 + CD62L + Tcm cells gating on CD8 + CD3 + CD45 + cells in the TDLNs. All data are presented as the mean +- s.e.m. ( n \u003d 5 per group) and n represents the number of independent animals. Statistical significance was calculated via one-way ANOVA with Tukey\u0027s multiple comparisons test. FMO fluorescence-minus-one. TDLN tumor-draining lymph node. Source data are provided as a Source Data file.','shortDescription':'Fig. 5 QD-Cat-RGD-based RT for promoting DC maturation and antigen presentation in TDLNs and consequently inducing T cell-driven antitumor immunity. a Representative flow cytometric analysis images and relative quantification of co-stimulatory molecules CD80 + CD86 + gating on CD45 + CD11c + cells in TDLNs. b Representative flow cytometric analysis images and relative quantification of MHC-II expression on ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 9, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19027_41467_2021_27485_Fig5_HTML.jpg','benchSciPubmedId':'34887404'},{'sku':'17-0441-82','imageId':'931818','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19124_gr1.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19124_gr1.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19124_gr1.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19124_gr1.jpg?time\u003d20240507','sortOrder':'25','description':'Figure 1 Deletion of CD95 in 4T1 cells inhibits tumor growth and cancer stemness in BALB/c mice but not in NSG mice (A) Wild-type (vCas9) or CD95 k.o. 4T1 (mixture of clones #54 and #69) cells (10 5 ) were injected into the fat pad of NSG mice. Bioluminescence of tumors was quantified at the indicated times after injection of cells. (B and C) Equal numbers of WT (Parental or vCas9) or CD95 k.o. (#54 or #69) 4T1 cells were transplanted into the mammary fat pad of NSG mice, and tumor weight (B) and tumor volume (C) were measured after two weeks. (D) Wild-type (mixture of clones #3 and #4) or CD95 k.o. 4T1 (mixture of clones #10 and #12) cells (10 5 ) were injected into the mammary fat pad of NSG mice, and tumor volume was measured using a caliper. (E) ALDH1 activity and CD44 surface staining of single-cell suspensions of tumors isolated from NSG mice. n \u003d 3 for each group. (F) IHC quantification of Ly6G positive cells in the WT and CD95 k.o. tumors monitored in (B). n \u003d 3 biological replicates. (G) Equal numbers of WT (Parental or vCas9) or CD95 k.o. (1:1 mixture of #54 or #69) 4T1 cells were transplanted into the mammary fat pad of NSG mice, and tumor nodules of the primary tumor on the surface of the lungs were counted two weeks after transplantation. (H) The appearance of representative lungs analyzed in (G). Scale bar, 5 mm. (I) Luciferase expressing wild-type (cCas9) or CD95 k.o. 4T1 (mixture of two k.o. clones) cells (10 5 ) were injected into the mammary fat pad of BALB/','shortDescription':'Figure 1 Deletion of CD95 in 4T1 cells inhibits tumor growth and cancer stemness in BALB/c mice but not in NSG mice (A) Wild-type (vCas9) or CD95 k.o. 4T1 (mixture of clones #54 and #69) cells (10 5 ) were injected into the fat pad of NSG mice. Bioluminescence of tumors was quantified at the indicated times after injection of cells. (B and C) Equal numbers of WT (Parental or vCas9) or CD95 k.o. (#54 or #69)... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Nov 19, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'iScience','journalText':'iScience 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19124_gr1.jpg','benchSciPubmedId':'34816102'},{'sku':'17-0441-82','imageId':'931909','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19127_jci-132-146071-g051.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19127_jci-132-146071-g051.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19127_jci-132-146071-g051.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19127_jci-132-146071-g051.jpg?time\u003d20240507','sortOrder':'26','description':'Figure 5 TNF superfamily members CD153 and CD30 are specifically expressed in SAT cells and ABCs, respectively, inside of TLTs in aged injured kidneys. ( A ) Dot plot of ligand-receptor interactions related to TNF superfamily members between 6 CD4 + T cell subpopulations and 3 B cell subpopulations identified by scRNA-Seq (see Figure 3 ). ( B ) Violin plots showing the expression of Tnfsf8 and Tnfrsf8 in all CD45 + cells. The putative identities of each cluster are specified in the box. DN, double-negative. ( C ) UMAP plot of Tnfsf8 and Tnfrsf8 in CD45 + cells in Figure 2B and enlargement of those of Cd4 , Tnfsf8 , Spp1 , Sostdc1 , Il21 , and Il10 , and those of Cd19 , Cr2 , Tbx21 , and Tnfrsf8 . ( D ) Representative FACS plots of CD153 expression on T cells, B cells, macrophages, dendritic cells, CD4 + T cells, CD8 + T cells, CD44 hi CD4 + T cells, and PD-1 + CD4 + T cells ( n \u003d 3/group). ( E ) Representative FACS plots of CD30 expression on T cells, B cells, macrophages, and dendritic cells ( n \u003d 2/group). ( F ) Plasma soluble CD30 (sCD30) levels of young and aged mice with or without (not treated, NT) ischemic reperfusion injury (IRI) induction ( n \u003d 3/group, samples were collected 45 days after IRI). Data are presented as mean +- SD. Statistical significance was determined by 1-way ANOVA with Bonferroni\u0027s post hoc analysis. *** P \u003c 0.001. ( G ) Violin plots showing the expression of Adam10 and Adam17 among 3 B cell subsets identified by scRNA-Seq. ( H ) Representative ISH','shortDescription':'Figure 5 TNF superfamily members CD153 and CD30 are specifically expressed in SAT cells and ABCs, respectively, inside of TLTs in aged injured kidneys. ( A ) Dot plot of ligand-receptor interactions related to TNF superfamily members between 6 CD4 + T cell subpopulations and 3 B cell subpopulations identified by scRNA-Seq (see Figure 3 ). ( B ) Violin plots showing the expression of Tnfsf8 and Tnfrsf8 in al... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jan 18, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of clinical investigation','journalText':'The Journal of clinical investigation 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19127_jci-132-146071-g051.jpg','benchSciPubmedId':'34813503'},{'sku':'17-0441-82','imageId':'931790','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19123_fimmu-12-726393-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19123_fimmu-12-726393-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19123_fimmu-12-726393-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19123_fimmu-12-726393-g001.jpg?time\u003d20240507','sortOrder':'27','description':'Figure 1 Homozygous RhoA deletion in Treg cells leads to early, fatal spontaneous inflammatory disorders. (A) Survival outcome of RhoA +/+ Foxp3 YFP-Cre and RhoA Flox/Flox Foxp3 YFP-Cre mice. Results were analyzed with a log-rank (Mantel-Cox) test and expressed as Kaplan-Meier survival curves. (B) Image of lymphadenopathy in RhoA Flox/Flox Foxp3 YFP-Cre mice. Inguinal lymph nodes are shown. (C) Images of H\u0026E staining of the indicated organs from RhoA +/+ Foxp3 YFP-Cre and RhoA Flox/Flox Foxp3 YFP-Cre mice (original magnification X 400). (D) Left, representative flow cytogram of CD44 and CD62L staining in CD4 + and CD8 + cells from the spleen of RhoA +/+ Foxp3 YFP-Cre and RhoA Flox/Flox Foxp3 YFP-Cre mice. The numbers indicate percentages of CD44 + , CD44 + CD62L + , and CD62L + cells. Right, average percentages of CD44 + , CD44 + CD62L + , and CD62L + cells. (E) Left, representative flow cytogram of IL-17, IFN-gamma, and IL-4 staining in CD4 + Foxp3 - cells from the spleen of RhoA +/+ Foxp3 YFP-Cre and RhoA Flox/Flox Foxp3 YFP-Cre mice. The numbers indicate percentages of IL-17 + , IFN-gamma + , and IL-4 + cells. Right, average percentages of IL-17 + , IFN-gamma + , and IL-4 + cells. (F) Left, representative flow cytogram of RORgammaT, T-bet and GATA3 staining in CD4 + Foxp3 - cells from the spleen of RhoA +/+ Foxp3 YFP-Cre and RhoA Flox/Flox Foxp3 YFP-Cre mice. The numbers indicate percentages of RORgammaT + , T-bet + , and GATA3 + cells. Right, average percentages of RORgam','shortDescription':'Figure 1 Homozygous RhoA deletion in Treg cells leads to early, fatal spontaneous inflammatory disorders. (A) Survival outcome of RhoA +/+ Foxp3 YFP-Cre and RhoA Flox/Flox Foxp3 YFP-Cre mice. Results were analyzed with a log-rank (Mantel-Cox) test and expressed as Kaplan-Meier survival curves. (B) Image of lymphadenopathy in RhoA Flox/Flox Foxp3 YFP-Cre mice. Inguinal lymph nodes are shown. (C) Images of H\u0026... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jan 11, 2022, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19123_fimmu-12-726393-g001.jpg','benchSciPubmedId':'34721389'},{'sku':'17-0441-82','imageId':'1019994','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24759_gr2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24759_gr2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24759_gr2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24759_gr2.jpg?time\u003d20240507','sortOrder':'28','description':'Experimental strategy and data example (Left) Experimental strategy for FACS analysis (A), co-culture analysis (B) and hematopoietic potential analysis (C). (Right) Representative experimental data. Scale bars, 50 mum.','shortDescription':'Experimental strategy and data example (Left) Experimental strategy for FACS analysis (A), co-culture analysis (B) and hematopoietic potential analysis (C). (Right) Representative experimental data. Scale bars, 50 mum.','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 17, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'STAR protocols','journalText':'STAR protocols 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24759_gr2.jpg','benchSciPubmedId':'34693362'},{'sku':'17-0441-82','imageId':'952657','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19088_nihms-1747909-f0004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19088_nihms-1747909-f0004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19088_nihms-1747909-f0004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19088_nihms-1747909-f0004.jpg?time\u003d20240507','sortOrder':'29','description':'Figure 3. Pik3cd E1020K/+ mice fail to develop a robust T CM population (A-F) Viable CD8 + splenocytes from mice infected with LCMV Armstrong (n \u003d 2, 4-5/group/time point). (A-C) NP396-specific CD8 + cells day 15 p.i. (A) CD127 and KLRG1 expression (left: representative staining; right: %KLRG1 + CD127 - ). (B) Representative histogram of CD27 (top) and CD127 (bottom). (C) GzmB and TCF1 staining. Middle: TCF1 MFI; right: GzmB MFI. (D-F) NP396-specific CD8 + cells day 58 p.i. (D) CD44 and CD62L staining. Representative flow (left), % CD44 hi CD62L lo cells (right). (E) CD127 histograms: CD44 hi CD62L lo (top) and CD44 hi CD62L + (bottom). (F) TCF1 MFI. (G) TCF1 staining of allo-reactive CD8 + cells from healthy controls and patients with APDS (n \u003d 2, representative histogram). (H-L) Mice were infected with X31 and challenged with PR8 (n \u003d 2, 3-5 mice/genotype/time point). (H) Infection outline. (I) PA224-specific CD8 + cell numbers. (J) IFN-gamma and TNF-alpha from day 8 cells stimulated with either PA 224-233 (left) or anti-CD3 plus anti-CD28 (right). (K) NP366-specific CD8 + T cell numbers. (L) IFN-gamma and TNF-alpha from day 35 cells stimulated with either NP 366-374 (left) or anti-CD3 plus anti-CD28 (right). (M-O) OT-1 cells were transferred into congenic hosts, infected with influenza X31-OVA and challenged with PR8-OVA (n \u003d 2, 3 mice/genotype/time point). (M) Outline. (N) Viable OT-1 cell numbers. (O) TCF1 and GzmB expression in OT-1 cells on day 35. Representative exper','shortDescription':'Figure 3. Pik3cd E1020K/+ mice fail to develop a robust T CM population (A-F) Viable CD8 + splenocytes from mice infected with LCMV Armstrong (n \u003d 2, 4-5/group/time point). (A-C) NP396-specific CD8 + cells day 15 p.i. (A) CD127 and KLRG1 expression (left: representative staining; right: %KLRG1 + CD127 - ). (B) Representative histogram of CD27 (top) and CD127 (bottom). (C) GzmB and TCF1 staining. Middle: TCF... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 12, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell reports','journalText':'Cell reports 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19088_nihms-1747909-f0004.jpg','benchSciPubmedId':'34644563'},{'sku':'17-0441-82','imageId':'931742','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19122_cancers-13-04917-g005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19122_cancers-13-04917-g005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19122_cancers-13-04917-g005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19122_cancers-13-04917-g005.jpg?time\u003d20240507','sortOrder':'30','description':'Figure 5 Forced expression of miR-125b-5p or knockdown of ATXN1 gene increases migration, invasion capability, and cancer stemness of HCC cell lines. ( a ) Representative image of the wound-healing assay in PLC/PRF5-miNC, PLC/PRF5-miR125b, and PLC/PRF5-R2-miNC cells (upper panel). The average migration distance was calculated from the wound healing area, and the time-dependent distance of migration is depicted in the lower panel (mean +- SD; n \u003d 3). ( b ) Similarly, representative images of the wound-healing assay and time-dependent distance of migration in PLC/PRF5-siNC, PLC/PRF5-siATXN1, and PLC/PRF5-R2-siNC cells are shown in the lower panel (mean +- SD; n \u003d 3). ( c ) Representative images of the invasion assay in PLC/PRF5-miNC, PLC/PRF5-miR125b, and PLC/PRF5-R2-miNC cells (left panel). The number of invading cells was counted, and the average numbers of invading cells are shown (right panel). ( d ) Similarly, representative invasion assay images and quantified invading cells in PLC/PRF5-siNC, PLC/PRF5-siATXN1, and PLC/PRF5-R2-siNC cells are shown. ( e ) Expression of CD44 and CD133 in PLC/PRF5-miNC and PLC/PRF5-miR125b cells was evaluated by two-color flow cytometry using mouse anti-human CD44 monoclonal antibody (APC) and mouse anti-human CD133 monoclonal antibody (PE). The percentage of CD44 + CD133 + cells based on the analysis of 10,000 cells is indicated. ( f ) Expression of CD44 and CD133 in PLC/PRF5-siNC and PLC/PRF5-siATXN1 cells was analyzed by flow cytometry and','shortDescription':'Figure 5 Forced expression of miR-125b-5p or knockdown of ATXN1 gene increases migration, invasion capability, and cancer stemness of HCC cell lines. ( a ) Representative image of the wound-healing assay in PLC/PRF5-miNC, PLC/PRF5-miR125b, and PLC/PRF5-R2-miNC cells (upper panel). The average migration distance was calculated from the wound healing area, and the time-dependent distance of migration is depic... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Sep 30, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cancers','journalText':'Cancers 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19122_cancers-13-04917-g005.jpg','benchSciPubmedId':'34638401'},{'sku':'17-0441-82','imageId':'931825','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19125_nihms-1746308-f0006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19125_nihms-1746308-f0006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19125_nihms-1746308-f0006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19125_nihms-1746308-f0006.jpg?time\u003d20240507','sortOrder':'31','description':'Figure 5. Rac1 inhibition enhances thymus regeneration and peripheral CD4 + naive T cell recovery after acute damage 6- to 8-week C57BL/6 WT or Nod2 -/- mice were treated with the Rac1 inhibitor EHT1864 (40 mg/kg i.p. injection) at days 3, 5, and 7 following a sublethal dose of TBI (550 cGy), and the thymus was analyzed on day 14. (A) Total thymic cellularity at day 14 after SL-TBI (WT, n \u003d 20/treatment across 4 independent experiments; KO, n \u003d 9-12 across three independent experiments). (B) Flow plots showing CD4 and CD8 expression at day 14 after SL-TBI (gated on CD45 + cells; plots were concatenated of all samples in each treatment group from one experiment). (C) Total number of DP, SP4, or SP8 thymocytes (n \u003d 20/treatment across 4 independent experiments). (D) Expression of miR29c analyzed by qPCR on whole thymic tissue (n \u003d 5/group). (E) Total thymic amounts of BMP4 and IL-23 assessed by ELISA at day 7 (n \u003d 4-5/group, representative of two independent experiments). (F) Total number of cTECs and mTECs (n \u003d 15/group across three independent experiments). (G) Flow plots showing CD4 and CD8 expression in the spleen at day 56 after SL-TBI (gated on CD45 + CD3 + cells). (H) Total number of CD4 + and CD8 + T cells in the spleen at d56 (n \u003d 5/group). (I) Plots of CD62L and CD44 on CD4 + and CD8 + T cells (gated on either CD45 + CD3 + CD4 + CD8 - or CD45 + CD3 + CD4 - CD8 + ) cells; plots concatenated of all samples in a given experiment). (J) Ratio of number of naive (CD62L hi C','shortDescription':'Figure 5. Rac1 inhibition enhances thymus regeneration and peripheral CD4 + naive T cell recovery after acute damage 6- to 8-week C57BL/6 WT or Nod2 -/- mice were treated with the Rac1 inhibitor EHT1864 (40 mg/kg i.p. injection) at days 3, 5, and 7 following a sublethal dose of TBI (550 cGy), and the thymus was analyzed on day 14. (A) Total thymic cellularity at day 14 after SL-TBI (WT, n \u003d 20/treatment acr... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 5, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell reports','journalText':'Cell reports 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19125_nihms-1746308-f0006.jpg','benchSciPubmedId':'34610317'},{'sku':'17-0441-82','imageId':'931679','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig5_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig5_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14839_41467_2021_25990_Fig5_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14839_41467_2021_25990_Fig5_HTML.jpg?time\u003d20240507','sortOrder':'32','description':'Fig. 5 HGF induced an effective therapeutic effect against B16F10 tumor. a Schematic illustration of the experiment design to assess the tumor inhibition and the immune responses as triggered by PBS, HACA-Fe, HACA-GW, or HGF NPs on subcutaneous B16F10 tumor model. G1, PBS; G2, HACA-Fe; G3, HACA-GW; G4, HGF. b and c Tumor growth curves during treatment. d Survival rates of different groups over time. e and f Representative flow cytometry plots and quantification of e CD8 + f and CD4 + T cells after gating on CD45 + CD3 + T cells in tumor tissue. g and h Representative flow cytometric analysis of memory T cells (CD3 + CD8 + CD44 + CD62L - , gated on CD3 + CD8 + T cells) in the spleen. Data were presented as mean +- SD. n \u003d 5 biologically independent animals per group. Statistically significant differences between groups were identified by one-way ANOVA with Tukey\u0027s post hoc test. * P \u003c 0.05, ** P \u003c 0.01, *** P \u003c 0.001 and **** P \u003c 0.0001.','shortDescription':'Fig. 5 HGF induced an effective therapeutic effect against B16F10 tumor. a Schematic illustration of the experiment design to assess the tumor inhibition and the immune responses as triggered by PBS, HACA-Fe, HACA-GW, or HGF NPs on subcutaneous B16F10 tumor model. G1, PBS; G2, HACA-Fe; G3, HACA-GW; G4, HGF. b and c Tumor growth curves during treatment. d Survival rates of different groups over time. e and f... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Sep 30, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14839_41467_2021_25990_Fig5_HTML.jpg','benchSciPubmedId':'34593794'},{'sku':'17-0441-82','imageId':'931700','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14887_gr6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14887_gr6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14887_gr6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14887_gr6.jpg?time\u003d20240507','sortOrder':'33','description':'Figure 6 Assessments of organ damage and mouse metabolites during HLSA or recovery from HLSA. A , upper left panel , MMP-1, IL-1beta, and CRP levels in plasma had no significant change between the control group, HLSA group, and R-HLSA group. Upper right panel , CK-MB as a marker of heart injury in the plasma had no significant change between the control group, HLSA group, and R-HLSA group. Lower left panel , creatinine and BUN as markers of kidney injury in the plasma slightly increased in the HLSA group and returned to normal level after recovery from HLSA. Lower right panel , AST and ALT as markers of liver injury in the plasma showed no change between the control group, HLSA group, and R-HLSA group. Data were presented as mean +- SD (N \u003d 6; ANOVA: ** p \u003c 0.01). B , upper panel , food consumption and water consumption 3 days before and 3 days after a single ATP-induced HLSA depicted no change. Data were presented as mean +- SD (N \u003d 6; ANOVA: p \u003e 0.05). Lower panel , metabolomics analysis of scores plot from PCA analysis based on 1 H NMR data from the plasma, brain, liver, and kidney of the control group, HLSA group, and R-HLSA group. The PCA score showcased clusters correspond to metabolic patterns in different groups, with each point representing one sample. Circles represent 95% confidence interval for each score in each group (see also Figs. S5-S8 ). C , draining lymph nodes of mice that underwent HLSA once a day for 10 consecutive days were analyzed with FACS. CD44 and','shortDescription':'Figure 6 Assessments of organ damage and mouse metabolites during HLSA or recovery from HLSA. A , upper left panel , MMP-1, IL-1beta, and CRP levels in plasma had no significant change between the control group, HLSA group, and R-HLSA group. Upper right panel , CK-MB as a marker of heart injury in the plasma had no significant change between the control group, HLSA group, and R-HLSA group. Lower left panel ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of biological chemistry','journalText':'The Journal of biological chemistry 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14887_gr6.jpg','benchSciPubmedId':'34487763'},{'sku':'17-0441-82','imageId':'931619','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15151_JEM_20201631_FigS2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15151_JEM_20201631_FigS2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15151_JEM_20201631_FigS2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15151_JEM_20201631_FigS2.jpg?time\u003d20240507','sortOrder':'34','description':'Figure S2. Mechanism of action of IRS661. (A) Schematic representation of the experimental setup. Mice were infected intranasally with 1,000 TCID 50 of influenza virus X31 and treated with IRS661 or PBS intranasally (15 nmol in 30 ul) on day 4 after infection. Usually, BALF was isolated on day 6 after infection. Colored dots mark days when mice were treated with alphaPDCA-1 (200-500 ug), 1A8 (150-300 ug), alphaSiglec-H (200-500 ug), or alphaCCR2 (20 ug) depletion antibody i.p. (B) WT 129S7 mice were infected with X31 and treated with IRS661 or PBS intranasally (15 nmol in 30 ul), i.p. (50 nmol in 100 ul), or intravenously (50 nmol in 100 ul) 4 d later. IFN-alpha concentrations were quantified by ELISA in BALF taken on day 5 after infection. n \u003d 3-11 mice per group. (C) Flow cytometry plots representing the gating strategy for cell analysis in Fig. 2 B . Lineage channel includes CD3, CD19, and NKp46. FSC, forward scatter; SSC, side scatter. (D) WT 129S7 mice were infected with 1,000 TCID 50 X31 and treated with IRS661, control ODN 2, or PBS intranasally. Survival was monitored for 14 d. n \u003d 17-18 mice per group. (E and F) Viral loads in lungs of X31-infected mice treated with IRS661 or PBS (E; n \u003d 3-7 mice per group) and/or aPDCA-1 antibody (F; n \u003d 6-7 mice per group) were determined by RT-qPCR or TCID 50 assay at days 2, 3, 5, and 7 (E) or day 6 (F) after infection. (G) WT C57BL/6 mice were infected with 10,000 TCID 50 X31 and treated with IRS661 or PBS intranasally. Survival','shortDescription':'Figure S2. Mechanism of action of IRS661. (A) Schematic representation of the experimental setup. Mice were infected intranasally with 1,000 TCID 50 of influenza virus X31 and treated with IRS661 or PBS intranasally (15 nmol in 30 ul) on day 4 after infection. Usually, BALF was isolated on day 6 after infection. Colored dots mark days when mice were treated with alphaPDCA-1 (200-500 ug), 1A8 (150-300 ug), a... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Nov 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of experimental medicine','journalText':'The Journal of experimental medicine 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15151_JEM_20201631_FigS2.jpg','benchSciPubmedId':'34473195'},{'sku':'17-0441-82','imageId':'931721','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14941_ADVS-8-2101848-g005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14941_ADVS-8-2101848-g005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14941_ADVS-8-2101848-g005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14941_ADVS-8-2101848-g005.jpg?time\u003d20240507','sortOrder':'35','description':'Figure 2 CD10 in CAFs sustains cancer stemness and chemoresistance. A-E) Indicated tumor cell lines were cultured alone (-) or cocultured with CD10 + GPR77 + -depleted CAFs (CD10 + GPR77 + -d) or paired CD10 + GPR77 + CAFs transduced without (-) or with shGFP or shCD10. A) Representative images of mammosphere formation in MCF-7 cells. Scale bar, 100 um. B) Representative images of PKH26 and Numb immunofluorescence staining of MCF-7 cells. Scale bar, 50 um. C,D) Percentage of ALDH1 + cells in C) MCF-7 and D) BT-549 cells detected by flow cytometry. Numerical values are presented as percentage (mean +- SEM, n \u003d 3). E) Percentage of CD44 high CD24 low cells in MCF-7 cells cocultured with indicated CAFs was detected by flow cytometry. Numerical values are presented as percentage (mean +- SEM, n \u003d 3). F,G) Representative flow cytometry plots for F) MCF-7 and G) BT-549 cells treated with docetaxel after being cultured alone (-) or cocultured with the indicated CAFs. The proportion of Annexin V + /Propidium iodide - (early apoptosis) and Annexin V + /Propidium iodide + (late apoptosis) cells is shown. The numerical values indicate Annexin V + percentage. Data are represented as the mean +- SEM of F) n \u003d 4 or G) n \u003d 3 independent experiments. H) Representative immunoblots for cleaved/total caspase-3 and PARP in SK-BR3 cells treated with docetaxel after being cultured alone (-) or cocultured with indicated CAFs ( n \u003d 3). I-L) MCF-7 cells were cocultured with CD10 + GPR77 + CAFs or CD1','shortDescription':'Figure 2 CD10 in CAFs sustains cancer stemness and chemoresistance. A-E) Indicated tumor cell lines were cultured alone (-) or cocultured with CD10 + GPR77 + -depleted CAFs (CD10 + GPR77 + -d) or paired CD10 + GPR77 + CAFs transduced without (-) or with shGFP or shCD10. A) Representative images of mammosphere formation in MCF-7 cells. Scale bar, 100 um. B) Representative images of PKH26 and Numb immunofluor... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Advanced science (Weinheim, Baden-Wurttemberg, Germany)','journalText':'Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14941_ADVS-8-2101848-g005.jpg','benchSciPubmedId':'34363355'},{'sku':'17-0441-82','imageId':'931598','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15143_fcell-09-695015-g007.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15143_fcell-09-695015-g007.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15143_fcell-09-695015-g007.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15143_fcell-09-695015-g007.jpg?time\u003d20240507','sortOrder':'36','description':'FIGURE 7 r Ts Pmy maintains majority of Tregs in an effective suppressor status (CD62L lo CD44 hi eTregs) with greater expression of functional phenotypes of TIGIT and CTLA4 in cLP with DSS-induced colitis. Flow cytometry results showed the frequencies of CD44 hi CD62L lo cells (A) and TIGIT + cells (B) in CD4 + Foxp3 + T cells of cLP from r Ts Pmy or PBS-treated mice with or without DSS colitis. The blank control of antibodies of CD62L and CD44 (A) was shown, and the antibody of TIGIT (B) were cut in FMO control samples. The corresponding percentages are shown on the right ( n \u003d 5). (C) The frequency of Foxp3 + CTLA4 + cells in CD3 + CD4 + T cells. The antibody of CTLA4 was cut in FMO control samples. The corresponding percentage is shown on the right ( n \u003d 3-5). The bars represent the mean +- SEM. * p \u003c 0.05. cLP, colonic lamina propria.','shortDescription':'FIGURE 7 r Ts Pmy maintains majority of Tregs in an effective suppressor status (CD62L lo CD44 hi eTregs) with greater expression of functional phenotypes of TIGIT and CTLA4 in cLP with DSS-induced colitis. Flow cytometry results showed the frequencies of CD44 hi CD62L lo cells (A) and TIGIT + cells (B) in CD4 + Foxp3 + T cells of cLP from r Ts Pmy or PBS-treated mice with or without DSS colitis. The blank ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Aug 3, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in cell and developmental biology','journalText':'Frontiers in cell and developmental biology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15143_fcell-09-695015-g007.jpg','benchSciPubmedId':'34336843'},{'sku':'17-0441-82','imageId':'931577','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15142_41420_2021_561_Fig5_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15142_41420_2021_561_Fig5_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15142_41420_2021_561_Fig5_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15142_41420_2021_561_Fig5_HTML.jpg?time\u003d20240507','sortOrder':'37','description':'Fig. 5 The 3-HAA increases the sensitivity of HCC cells to sorafenib by suppressing stemness. A The cell viability of 3-HAA-treated SMMC-7721 and PLC8024 cells was analyzed by CCK8 assay. Cells were treated with sorafenib at the indicated dose with or without 100 muM 3-HAA for 4 days. * P \u003c 0.05. B The combination of 3-HAA and sorafenib dramatically inhibited ALDH, SOX2, and OCT4 expression in SMMC-7721 and PLC8024 cells. Cells were treated with 100 muM of 3-HAA and sorafenib at the indicated dose for 24 h. C The combination of sorafenib and 3-HAA significantly reduced the proportion of CD133 + CD44 + tumor cells than either 3-HAA alone or sorafenib alone in SMMC-7721 and PLC8024 cells. Cells were treated with 100 muM 3-HAA and 5 muM sorafenib for 24 h. * P \u003c 0.05, ** P \u003c 0.01. D CHIR99021 recovered the AKT/GSK3beta/beta-catenin signaling and the expression of stemness markers, inhibited by the combination treatment. Cells were treated with 100 muM 3-HAA, 5 muM sorafenib, and/or 5 muM CHIR99021 for 24 h. E CHIR99021 recovered the combination-suppressed tumor growth of SMMC-7721 xenografts. 3-HAA and sorafenib were separately administrated by intraperitoneal injection for 16 days at the dose of 100 and 10 mg/kg day, respectively. CHIR99021 was administered orally at 40 mg/kg day, five mice were recruited in each group. The tumor volumes are presented as mean +- SD. ** P \u003c 0.01. F CHIR99021 increased the ratio of CD44 + CD133 + subpopulation in SMMC-7721 xenografts. Tumor cells','shortDescription':'Fig. 5 The 3-HAA increases the sensitivity of HCC cells to sorafenib by suppressing stemness. A The cell viability of 3-HAA-treated SMMC-7721 and PLC8024 cells was analyzed by CCK8 assay. Cells were treated with sorafenib at the indicated dose with or without 100 muM 3-HAA for 4 days. * P \u003c 0.05. B The combination of 3-HAA and sorafenib dramatically inhibited ALDH, SOX2, and OCT4 expression in SMMC-7721 and... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jul 6, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death discovery','journalText':'Cell death discovery 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15142_41420_2021_561_Fig5_HTML.jpg','benchSciPubmedId':'34230478'},{'sku':'17-0441-82','imageId':'931556','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15142_41420_2021_561_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15142_41420_2021_561_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15142_41420_2021_561_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15142_41420_2021_561_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'38','description':'Fig. 3 3-hydroxyanthranic acid inhibits tumor stemness of sorafenib-resistant HCC cells. A 3-HAA inhibited cell growth of sorafenib-resistant HCC cells. Cell numbers of HCC cells were counted by cytometry. Data were presented as mean +- SD ( n \u003d 3). * P \u003c 0.05, ** P \u003c 0.01. B 3-HAA reduced colony formation in sorafenib-resistant SMMC-7721 and PLC8024 cells. Cells were treated with 3-HAA at the indicated dose. * P \u003c 0.05, ** P \u003c 0.01. C The ratio of CD44 + CD133 + subpopulation was decreased in 3-HAA-treated SMMC-7721 and PLC8024 cells. Cells were treated with 3-HAA at the dose of 100 muM for 48 h. * P \u003c 0.05. D 3-HAA inhibited the expression of stem cell markers in HCC cells. The treating time was 48 h for the dose-response experiment and the dose of 3-HAA was 100 muM for the time-course analysis. E 3-HAA suppressed tumor growth of SMMC-7721 xenografts. The 3-HAA was administrated 100 mg/kg day by intraperitoneal injection for 16 days, five mice were recruited in the control and 3-HAA-treated group. The tumor volumes were presented as mean +- SD. * P \u003c 0.05. F 3-HAA decreased the proportion of CD44 + CD133 + subpopulation in SMMC-7721 xenografts. Tumor cells were analyzed by flow cytometry using anti-CD133-PE and anti-CD44-APC. * P \u003c 0.05. G 3-HAA inhibited the expression of stem cell markers in SMMC-7721 xenografts. Bar \u003d 100 mum.','shortDescription':'Fig. 3 3-hydroxyanthranic acid inhibits tumor stemness of sorafenib-resistant HCC cells. A 3-HAA inhibited cell growth of sorafenib-resistant HCC cells. Cell numbers of HCC cells were counted by cytometry. Data were presented as mean +- SD ( n \u003d 3). * P \u003c 0.05, ** P \u003c 0.01. B 3-HAA reduced colony formation in sorafenib-resistant SMMC-7721 and PLC8024 cells. Cells were treated with 3-HAA at the indicated dos... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jul 6, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death discovery','journalText':'Cell death discovery 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15142_41420_2021_561_Fig3_HTML.jpg','benchSciPubmedId':'34230478'},{'sku':'17-0441-82','imageId':'931535','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15142_41420_2021_561_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15142_41420_2021_561_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15142_41420_2021_561_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15142_41420_2021_561_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'39','description':'Fig. 1 Tumor stemness is increased in sorafenib-resistant hepatocellular carcinoma cells. A SMMC-7721 and PLC8024 cells were more resistant to sorafenib than HepG2 and Hep3B cells. HCC cells were treated with 0-40 muM sorafenib and the cell viability was analyzed by the CCK8 assay. Data were presented as mean +- SD ( n \u003d 3). B The KEGG analysis on the upregulated/downregulated genes. The genes expression changed more than 2 folds were analyzed between sorafenib-resistant vs. sorafenib-sensitive HCC cells. C Heatmap of gene expression participated in cell cycle pathway, Wnt signaling, and PI3K-AKT pathway. The levels of the gene expression were reflected by different colors, colors from blue to red stood for expression levels from low expression to high expression. D The expression of stem cell markers was enhanced in sorafenib-resistant HCC cells. The expression of ALDH, SOX2, and OCT4 was analyzed. E The CD44 + CD133 + subpopulations were increased in sorafenib-resistant HCC cells. The CD44 + CD133 + subpopulation was analyzed by flow cytometry using anti-CD44 and anti-CD133 antibodies. * P \u003c 0.05, ** P \u003c 0.01. F Stemness was increased in sorafenib-resistant HCC tumors. OCT4 and NANOG expression were detected by IHC. Bar \u003d 100 mum.','shortDescription':'Fig. 1 Tumor stemness is increased in sorafenib-resistant hepatocellular carcinoma cells. A SMMC-7721 and PLC8024 cells were more resistant to sorafenib than HepG2 and Hep3B cells. HCC cells were treated with 0-40 muM sorafenib and the cell viability was analyzed by the CCK8 assay. Data were presented as mean +- SD ( n \u003d 3). B The KEGG analysis on the upregulated/downregulated genes. The genes expression ch... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jul 6, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death discovery','journalText':'Cell death discovery 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15142_41420_2021_561_Fig1_HTML.jpg','benchSciPubmedId':'34230478'},{'sku':'17-0441-82','imageId':'931514','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15141_41419_2021_3936_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15141_41419_2021_3936_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15141_41419_2021_3936_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15141_41419_2021_3936_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'40','description':'Fig. 1 Mesodermal progenitors can be derived trough a chemically defined monolayer approach. A Schematic overview of the protocol to differentiate induced pluripotent stem cells towards mesodermal progenitors. B - D Gene expression of markers for pluripotency, early and late mesoderm, ectoderm, and endoderm during mesoderm differentiation. E FACS analysis of Mesogenin1 (MSGN1) during differentiation using a MSGN1-2A-Venus reporter line. F Percentage of MSGN1, CD44, and CD140A/B positive cells during differentiation, based on FACS analysis. * P \u003c 0.05; ** P \u003c 0.01; *** P \u003c 0.001; **** P \u003c 0.0001. n \u003d 3-4.','shortDescription':'Fig. 1 Mesodermal progenitors can be derived trough a chemically defined monolayer approach. A Schematic overview of the protocol to differentiate induced pluripotent stem cells towards mesodermal progenitors. B - D Gene expression of markers for pluripotency, early and late mesoderm, ectoderm, and endoderm during mesoderm differentiation. E FACS analysis of Mesogenin1 (MSGN1) during differentiation using a... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jul 5, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15141_41419_2021_3936_Fig1_HTML.jpg','benchSciPubmedId':'34226515'},{'sku':'17-0441-82','imageId':'931493','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15140_gr5.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15140_gr5.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15140_gr5.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15140_gr5.jpg?time\u003d20240507','sortOrder':'41','description':'Figure 5 Impact of Mito-MGN on T cell activation and effector functions (A) Schematic for analyzing Mito-MGN effects on splenic T cells. (B-D) Changes in T cell activation. Representative flow cytometry plots of CD44 hi CD62L lo levels in T cells (B). Enumeration of activated T cells of CD4 + (C) and CD8 + (D) T cell subsets in Mito-MGN treated and vehicle control cells. Values are mean +- SD, n \u003d 6 independent experiments. Statistical significance determined using a Student\u0027s t-test (**, p\u003c 0.01; ***, p\u003c 0.001). Effects of Mito-MGN on T cell proliferation and early activation markers are shown in Figure S8 . (E) Realtime measurement of extracellular acidification rate (ECAR) (left panel) and oxygen consumption rate (OCR) in treated T cells Values are mean +- SD of n \u003d 3 biological replicates completed in technical quadruplicate. Statistical differences at individual time points were analyzed using Student\u0027s t-test (****, p\u003c 0.0001). (F and G) IsoPlexis IsoLight assay measured Polyfunctionality Strength Index (PSI) scores (F) and effector or inflammatory cytokine levels (G) in Mito-MGN treated compared to vehicle control T cells. Values are mean +- SD from 2 biological replicates.','shortDescription':'Figure 5 Impact of Mito-MGN on T cell activation and effector functions (A) Schematic for analyzing Mito-MGN effects on splenic T cells. (B-D) Changes in T cell activation. Representative flow cytometry plots of CD44 hi CD62L lo levels in T cells (B). Enumeration of activated T cells of CD4 + (C) and CD8 + (D) T cell subsets in Mito-MGN treated and vehicle control cells. Values are mean +- SD, n \u003d 6 indepen... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jun 25, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'iScience','journalText':'iScience 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15140_gr5.jpg','benchSciPubmedId':'34189432'},{'sku':'17-0441-82','imageId':'840110','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12510_gr2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12510_gr2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12510_gr2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12510_gr2.jpg?time\u003d20240507','sortOrder':'42','description':'Fig. 2 CD25 expression on tumor-infiltrating lymphocytes. (a) Tumor-infiltrating lymphocytes were analyzed with flow cytometry. Tregs accounted for 49.8% of CD4 + T cells. (b) 71.5% of CD25 positive cells were CD3 + CD4 + Foxp3 + Tregs (c) Upper: Surface expression of CD25 was evaluated for NK cells, CD8 + T cells, CD4 + Foxp3 - T cells, and CD4 + Foxp3 + Tregs. Lower: CD4 + Foxp3 + Tregs showed significantly higher mean fluorescence intensity (MFI) of CD25 (left) and CD25 positive percentage (right) ( n \u003d 4; one-way ANOVA followed by Tukey\u0027\u0027s test; ****, p \u003c 0.0001). Fig 2','shortDescription':'Fig. 2 CD25 expression on tumor-infiltrating lymphocytes. (a) Tumor-infiltrating lymphocytes were analyzed with flow cytometry. Tregs accounted for 49.8% of CD4 + T cells. (b) 71.5% of CD25 positive cells were CD3 + CD4 + Foxp3 + Tregs (c) Upper: Surface expression of CD25 was evaluated for NK cells, CD8 + T cells, CD4 + Foxp3 - T cells, and CD4 + Foxp3 + Tregs. Lower: CD4 + Foxp3 + Tregs showed significant... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'May 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'EBioMedicine','journalText':'EBioMedicine 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12510_gr2.jpg','benchSciPubmedId':'33933782'},{'sku':'17-0441-82','imageId':'931472','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15116_fimmu-12-642420-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15116_fimmu-12-642420-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15116_fimmu-12-642420-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15116_fimmu-12-642420-g003.jpg?time\u003d20240507','sortOrder':'43','description':'Figure 3 Paclitaxel dysregulates CD4 + and CD8 + T-cell subpopulations in an eIF4E-dependent manner. (A) Gating strategy used for flow cytometry of lymphocytes from popliteal and inguinal lymph nodes. T-cells were separated from the whole lymphoid cells population using CD3. CD3 + cells were then gated for CD4 + T-cell and CD8 + T-cells. For each of these subsets, cells were further gated for CCR7 or CD25 and CD44. (B) Quantification of CD4 + T-cells from the CD3 population from male mice. (C) CCR7 + T-cells from isolated CD4 + population in males, ** p 0.0063. (D) CD4 + cells gated for CD25 and/or CD44 in males. (E) Quantification of CD4 + T-cells from the CD3 + population from female mice, * p 0.0101. (F) CCR7 + T-cells from isolated CD4 + population in female mice, * p 0.0250. (G) CD4 + cells gated for CD25 and/or CD44 in female mice, ** p 0.0011. (H) Quantification of CD8 + T-cells from the CD3 + population from male mice. (I) CCR7 + T-cells from isolated CD8 + population in males, * p 0.0433. (J) CD8 + cells gated for CD25 and/or CD44 in males, * p 0.0396. (K) Quantification of CD8 + T-cells from the CD3 population from female mice, * p 0.041. (L) CCR7 + T-cells from isolated CD8 + population in female mice, ** p 0.0097. (M) CD8 + cells gated for CD25 and/or CD44 in female mice. All data are presented as mean +- standard error of the mean, n \u003d 3 mice each for male/female WT vehicle-treated and WT paclitaxel groups, n \u003d 4 mice each for male/female eIF4E S209A vehicle-trea','shortDescription':'Figure 3 Paclitaxel dysregulates CD4 + and CD8 + T-cell subpopulations in an eIF4E-dependent manner. (A) Gating strategy used for flow cytometry of lymphocytes from popliteal and inguinal lymph nodes. T-cells were separated from the whole lymphoid cells population using CD3. CD3 + cells were then gated for CD4 + T-cell and CD8 + T-cells. For each of these subsets, cells were further gated for CCR7 or CD25 a... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Sep 20, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15116_fimmu-12-642420-g003.jpg','benchSciPubmedId':'33912169'},{'sku':'17-0441-82','imageId':'931451','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15139_apb-11-361-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15139_apb-11-361-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15139_apb-11-361-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15139_apb-11-361-g001.jpg?time\u003d20240507','sortOrder':'44','description':'Figure 1 AD-MSCs characterization; (A) Flow cytometry assay to assess the CD markers in the surface of extracted AD-MSCs. Target cells were positive for CD73 (95.1%), and CD90 (90.6%) surface markers and were negative for CD44 and CD34 markers. (B) Morphology of AD-MSCs at passage 3. (C) Oil red staining to prove the adipogenic potential differentiation of AD-MSCs. (D) Alizarin-red staining to confirm the osteogenic potential differentiation of AD-MSCs. Scale bar \u003d 100 mum. Abbreviations: AD-MSCs: adipose-derived mesenchymal stem cells.','shortDescription':'Figure 1 AD-MSCs characterization; (A) Flow cytometry assay to assess the CD markers in the surface of extracted AD-MSCs. Target cells were positive for CD73 (95.1%), and CD90 (90.6%) surface markers and were negative for CD44 and CD34 markers. (B) Morphology of AD-MSCs at passage 3. (C) Oil red staining to prove the adipogenic potential differentiation of AD-MSCs. (D) Alizarin-red staining to confirm the o... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Advanced pharmaceutical bulletin','journalText':'Advanced pharmaceutical bulletin 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15139_apb-11-361-g001.jpg','benchSciPubmedId':'33880359'},{'sku':'17-0441-82','imageId':'931086','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15145_EMS117746-f006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15145_EMS117746-f006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15145_EMS117746-f006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15145_EMS117746-f006.jpg?time\u003d20240507','sortOrder':'45','description':'Figure 6 Enhanced chromosomal instability induced by MSL disruption exhausts cancer cell proliferative capacity. a . Clonogenic assays comparing MSL LOF ( MSL3 -KO) and control TDF cells visualized by crystal violet staining. Scale bar: 1 mm. b . DNA FISH detecting the pericentromeric region of chromosome 12 in clonal populations grown for 14 d. Cells from distinct locations within the clones are juxtaposed. Scale bar: 10 mum. c-d . Quantification of CIN score ( c ) and relationship with clone size ( d ). N \u003d 105, 96, 121 biologically independent clones collected from two experiments. Horizontal lines: median values. P-value from one-way ANOVA followed by Tukey\u0027s test ( c ) and two-sided Spearman correlation test (MSL LOF cells in d ). N.s. : non-significant (p-value \u003e 0.99). R s : correlation coefficient for MSL LOF cells. e-h. Immunodetection of Ki67 ( e , g ) and quantification of non-proliferative Ki67-negative cells ( f , h ). N \u003d 100, 102, 130, 1375, 1300 independent cells for DMSO, 4d and 6d reversine, cntr-KO and MSL LOF ( MSL3 -KO) cells collected from two experiments. MEXF-2090 cells are shown in g - h ; TDF and other PDX-derived cells showed similar results. P-value from two-tailed Fisher\u0027s exact test. Scale bar: 10 mum. i-j . Limiting dilution clonogenic assays. Phase contrast images of DMSO- and reversine-treated TDF cells 12 d after plating ( i ) and quantification of populated wells ( j ). The percentage of wells containing at least one clone larger than 20 cel','shortDescription':'Figure 6 Enhanced chromosomal instability induced by MSL disruption exhausts cancer cell proliferative capacity. a . Clonogenic assays comparing MSL LOF ( MSL3 -KO) and control TDF cells visualized by crystal violet staining. Scale bar: 1 mm. b . DNA FISH detecting the pericentromeric region of chromosome 12 in clonal populations grown for 14 d. Cells from distinct locations within the clones are juxtaposed... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature cell biology','journalText':'Nature cell biology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15145_EMS117746-f006.jpg','benchSciPubmedId':'33837287'},{'sku':'17-0441-82','imageId':'931241','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15147_biol-13-129-g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15147_biol-13-129-g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15147_biol-13-129-g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15147_biol-13-129-g002.jpg?time\u003d20240507','sortOrder':'46','description':'Figure 2 The proportion of CD8 + effector memory T (Tem) cells and levels of IFN-gamma, mTOR and S6K in CD8 + Tem cells were significantly increased by IL-12 stimulation but significantly decreased by rapamycin treatment. The peripheral blood mononuclear cells obtained from the cyclophosphamide plus invasive pulmonary aspergillosis (CTX + IPA) mice, CTX + IPA mice treated with IL-12 (CTX + IPA+IL-12) or rapamycin (CTX + IPA+RAPA), and control animals were assessed using flow cytometry seven days after A . fumigatus infection. The side scatter (SSC) and CD8a were applied to gate on CD8 + T lymphocytes, CD44 + CD45 + CD62 +/- were considered to represent the Tem cells. Representative dot plots are shown, and the percentages of Tem cells and of Tem cells expressing IFNgamma, mTOR, and S6K are expressed as the mean +- S.D. * p \u003c 0.05; ** p \u003c 0.01; *** p \u003c 0.001.','shortDescription':'Figure 2 The proportion of CD8 + effector memory T (Tem) cells and levels of IFN-gamma, mTOR and S6K in CD8 + Tem cells were significantly increased by IL-12 stimulation but significantly decreased by rapamycin treatment. The peripheral blood mononuclear cells obtained from the cyclophosphamide plus invasive pulmonary aspergillosis (CTX + IPA) mice, CTX + IPA mice treated with IL-12 (CTX + IPA+IL-12) or rap... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jan 1, 2018, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Open life sciences','journalText':'Open life sciences 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15147_biol-13-129-g002.jpg','benchSciPubmedId':'33817078'},{'sku':'17-0441-82','imageId':'931262','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15147_biol-13-129-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15147_biol-13-129-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15147_biol-13-129-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15147_biol-13-129-g003.jpg?time\u003d20240507','sortOrder':'47','description':'Figure 3 IL-12 significantly increased the expression of T-bet but significantly decreased the expression of Eomesodermin in CD8 + effector memory T (Tem) cells, which was blocked by rapamycin treatment. The peripheral blood mononuclear cells obtained from the cyclophosphamide plus invasive pulmonary aspergillosis (CTX + IPA) mice, CTX + IPA mice treated with IL-12(CTX + IPA+IL-12) or rapamycin (CTX + IPA+RAPA), and control animals were assessed using flow cytometry seven days after A . fumigatus infection. The side scatter (SSC) and CD8a were applied to gate on CD8 + T lymphocytes, CD44 + CD45 + CD62 +/- were considered to represent the Tem cells. Representative dot plots are shown, and the percentages of Tem cells and of Tem cells expressing T-bet and Eomesodermin are expressed as the mean +- S.D. * p \u003c 0.05; ** p \u003c 0.01; *** p \u003c 0.001.','shortDescription':'Figure 3 IL-12 significantly increased the expression of T-bet but significantly decreased the expression of Eomesodermin in CD8 + effector memory T (Tem) cells, which was blocked by rapamycin treatment. The peripheral blood mononuclear cells obtained from the cyclophosphamide plus invasive pulmonary aspergillosis (CTX + IPA) mice, CTX + IPA mice treated with IL-12(CTX + IPA+IL-12) or rapamycin (CTX + IPA+R... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jan 1, 2018, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Open life sciences','journalText':'Open life sciences 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15147_biol-13-129-g003.jpg','benchSciPubmedId':'33817078'},{'sku':'17-0441-82','imageId':'931367','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15050_fcell-09-637424-g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15050_fcell-09-637424-g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15050_fcell-09-637424-g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15050_fcell-09-637424-g002.jpg?time\u003d20240507','sortOrder':'48','description':'FIGURE 2 T cell senescence in various adipose tissues of old mice. (A,B) Flow cytometric analysis of CD45 + CD3 + T cells in AT of young and old mice and their quantitation. (C,D) Representative flow cytometric analysis of CD44 subsets in T cells isolated from adipose tissue and their quantification. (E,F) Representative flow cytometry of CD28 + T cells in adipose tissue from young or old mice and their quantification. * P \u003c 0.05; ** P \u003c 0.01; *** P \u003c 0.001 vs. young mice, n \u003d 3~6 per group.','shortDescription':'FIGURE 2 T cell senescence in various adipose tissues of old mice. (A,B) Flow cytometric analysis of CD45 + CD3 + T cells in AT of young and old mice and their quantitation. (C,D) Representative flow cytometric analysis of CD44 subsets in T cells isolated from adipose tissue and their quantification. (E,F) Representative flow cytometry of CD28 + T cells in adipose tissue from young or old mice and their qua... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Mar 23, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in cell and developmental biology','journalText':'Frontiers in cell and developmental biology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15050_fcell-09-637424-g002.jpg','benchSciPubmedId':'33748126'},{'sku':'17-0441-82','imageId':'931388','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15137_12935_2021_1872_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15137_12935_2021_1872_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15137_12935_2021_1872_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15137_12935_2021_1872_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'49','description':'Fig. 3 Expression levels of CD44 and EpCAM on KatoIII cells surface and the effect of transient transfection of miR-34a-5p mimic on these markers expression. a The flow cytometry analysis indicated that EpCAM and CD44 are expressed in almost all and ~ 97% of KatoIII cells, respectively. The expression of CD44 on KatoIII cells showed lower intensity than EpCAM expression. In addition, two sub-populations of EpCAM positive cells with different fluorescence intensity were observed in KatoIII cell line. b The frequency and MFI of EpCAM marker were compared between adhesive KatoIII cells dissociated from the flask using trypsin enzyme and non-adhesive KatoIII cells. Data showed that the use of trypsin enzyme for detachment of the adherent cells from the flask reduced the fluorescence intensity of EpCAM (116.5 +- 0.7), in comparison to the suspended cells (180 +- 5.65). But, the use of trypsin enzyme for detachment of the adherent cells had no effect on the frequency of EpCAM positive cells. c According to the flow cytometry analysis, transient transfection of the miR-34a-5p mimic at 25 nM had no effect on percentage of CD44 and EpCAM positive cells in KatoIII cells. MFI: Median Fluorescence Intensity','shortDescription':'Fig. 3 Expression levels of CD44 and EpCAM on KatoIII cells surface and the effect of transient transfection of miR-34a-5p mimic on these markers expression. a The flow cytometry analysis indicated that EpCAM and CD44 are expressed in almost all and ~ 97% of KatoIII cells, respectively. The expression of CD44 on KatoIII cells showed lower intensity than EpCAM expression. In addition, two sub-populations of ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Mar 19, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cancer cell international','journalText':'Cancer cell international 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15137_12935_2021_1872_Fig3_HTML.jpg','benchSciPubmedId':'33740991'},{'sku':'17-0441-82','imageId':'931409','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15137_12935_2021_1872_Fig5_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15137_12935_2021_1872_Fig5_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15137_12935_2021_1872_Fig5_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15137_12935_2021_1872_Fig5_HTML.jpg?time\u003d20240507','sortOrder':'50','description':'Fig. 5 The effect of stable transfection of pre-mir-34a on the expression levels of CD44 and EpCAM markers. The flow cytometric detection illustrated that the percentage of CD44 + cells and the MFI of CD44 marker were significantly decreased in the KatoIII-pGFPC1-34a cells compared to the KatoIII-pGFPC1- empty cells. No difference was found in percentage of EpCAM + cells between these two stable cells. *p \u003c 0.05; **p \u003c 0.01. MFI: Median Fluorescence Intensity','shortDescription':'Fig. 5 The effect of stable transfection of pre-mir-34a on the expression levels of CD44 and EpCAM markers. The flow cytometric detection illustrated that the percentage of CD44 + cells and the MFI of CD44 marker were significantly decreased in the KatoIII-pGFPC1-34a cells compared to the KatoIII-pGFPC1- empty cells. No difference was found in percentage of EpCAM + cells between these two stable cells. *p \u003c... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Mar 19, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cancer cell international','journalText':'Cancer cell international 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15137_12935_2021_1872_Fig5_HTML.jpg','benchSciPubmedId':'33740991'},{'sku':'17-0441-82','imageId':'931430','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15138_EMMM-13-e13390-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15138_EMMM-13-e13390-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15138_EMMM-13-e13390-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15138_EMMM-13-e13390-g003.jpg?time\u003d20240507','sortOrder':'51','description':'Figure EV3 Sporozoite surface antigen induces a greater effector CD8 + T-cell phenotype than EEF vacuolar membrane antigen C57BL/6 mice received 2 x 10 6 OT-I cells alone ( n \u003d 2) or were additionally immunised with 10,000 gamma-radiation attenuated WT ( n \u003d 3), CSP SIINFEKL ( n \u003d 4) or UIS4 SIINFEKL ( n \u003d 4) sporozoites intravenously. Spleens and livers were harvested either 14 or 42 days later, and proportions of CD8 + T cells expressing effector surface markers were quantified. Flow cytometry plots show representative percentages of CD8 + T cells co-staining K b -SIINFEKL and markers of effector phenotype (CD11a hi , CD49d hi , CD62L lo , CD44 hi ).','shortDescription':'Figure EV3 Sporozoite surface antigen induces a greater effector CD8 + T-cell phenotype than EEF vacuolar membrane antigen C57BL/6 mice received 2 x 10 6 OT-I cells alone ( n \u003d 2) or were additionally immunised with 10,000 gamma-radiation attenuated WT ( n \u003d 3), CSP SIINFEKL ( n \u003d 4) or UIS4 SIINFEKL ( n \u003d 4) sporozoites intravenously. Spleens and livers were harvested either 14 or 42 days later, and propor... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Apr 9, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'EMBO molecular medicine','journalText':'EMBO molecular medicine 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15138_EMMM-13-e13390-g003.jpg','benchSciPubmedId':'33709544'},{'sku':'17-0441-82','imageId':'930444','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15123_urn-x-wiley-17574676-media-emmm202013390-emmm202013390-fig-0003ev.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15123_urn-x-wiley-17574676-media-emmm202013390-emmm202013390-fig-0003ev.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15123_urn-x-wiley-17574676-media-emmm202013390-emmm202013390-fig-0003ev.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15123_urn-x-wiley-17574676-media-emmm202013390-emmm202013390-fig-0003ev.jpg?time\u003d20240507','sortOrder':'52','description':'EV3 Figure Sporozoite surface antigen induces a greater effector CD8 + T-cell phenotype than EEF vacuolar membrane antigen C57BL/6 mice received 2 x 10 6 OT-I cells alone ( n \u003d 2) or were additionally immunised with 10,000 gamma-radiation attenuated WT ( n \u003d 3), CSP SIINFEKL ( n \u003d 4) or UIS4 SIINFEKL ( n \u003d 4) sporozoites intravenously. Spleens and livers were harvested either 14 or 42 days later, and proportions of CD8 + T cells expressing effector surface markers were quantified. Flow cytometry plots show representative percentages of CD8 + T cells co-staining K b -SIINFEKL and markers of effector phenotype (CD11a hi , CD49d hi , CD62L lo , CD44 hi ).','shortDescription':'EV3 Figure Sporozoite surface antigen induces a greater effector CD8 + T-cell phenotype than EEF vacuolar membrane antigen C57BL/6 mice received 2 x 10 6 OT-I cells alone ( n \u003d 2) or were additionally immunised with 10,000 gamma-radiation attenuated WT ( n \u003d 3), CSP SIINFEKL ( n \u003d 4) or UIS4 SIINFEKL ( n \u003d 4) sporozoites intravenously. Spleens and livers were harvested either 14 or 42 days later, and propor... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Apr 9, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'EMBO molecular medicine','journalText':'EMBO molecular medicine 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15123_urn-x-wiley-17574676-media-emmm202013390-emmm202013390-fig-0003ev.jpg','benchSciPubmedId':'33709544'},{'sku':'17-0441-82','imageId':'931304','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15148_pone.0247990.g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15148_pone.0247990.g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15148_pone.0247990.g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15148_pone.0247990.g004.jpg?time\u003d20240507','sortOrder':'53','description':'10.1371/journal.pone.0247990.g004 Fig 4 Immunogenicity of C57BL/6 mice four weeks after the final immunization with ID93+GLA-LSQ. Mice were immunized with ID93 combined with GLA-LS containing different QS-21 doses (10, 2 or 0.4 mug). (A) The percent frequency of single-cytokine producing ID93-specific CD4+ T cells. Bars represent the mean of the group, with vertical lines indicating SD. Groups were compared for each cytokine using one-way ANOVA with Bonferroni\u0027s multiple comparison test, with * p \u003c0.05, ** p \u003c0.01, **** p \u003c0.0001 versus ID93 alone, an exact p value is shown for values near significance; (B) percent of polyfunctional ID93-specific CD4+CD44+CD154+ T cells producing one or more cytokines. The data are represented as the percentage of CD4+CD44+CD154+ T cells producing one or more cytokines following ex-vivo stimulation with ID93; cytokine producing subsets are shown as stacked bars, with mean + SD of each subset. Comparisons of total cytokine producing cells between groups were performed using one-way ANOVA with Bonferroni\u0027s multiple comparison test, * p \u003c0.05, ** p \u003c0.01, **** p \u003c0.0001; (C) percent CD4+ T cell cytotoxicity. Mean and SD, with individual mice, are shown. Comparisons between the groups were performed using one-way ANOVA with Bonferroni\u0027s multiple comparison test; ** p \u003c0.01, *** p \u003c0.001, **** p \u003c0.0001 versus ID93 alone.','shortDescription':'10.1371/journal.pone.0247990.g004 Fig 4 Immunogenicity of C57BL/6 mice four weeks after the final immunization with ID93+GLA-LSQ. Mice were immunized with ID93 combined with GLA-LS containing different QS-21 doses (10, 2 or 0.4 mug). (A) The percent frequency of single-cytokine producing ID93-specific CD4+ T cells. Bars represent the mean of the group, with vertical lines indicating SD. Groups were compared... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 13, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15148_pone.0247990.g004.jpg','benchSciPubmedId':'33705411'},{'sku':'17-0441-82','imageId':'931325','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15148_pone.0247990.g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15148_pone.0247990.g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15148_pone.0247990.g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15148_pone.0247990.g006.jpg?time\u003d20240507','sortOrder':'54','description':'10.1371/journal.pone.0247990.g006 Fig 6 Prophylactic protection with ID93+GLA-SE and ID93+GLA-LSQ in C57BL/6 mice. Mice were immunized with ID93 combined with different adjuvant formulations including SE, LS (liposomes), LSQ (liposomes+QS21), GLA-LS, GLA-LSQ, or GLA-SE. (A) The percent frequency of single-cytokine producing ID93-specific CD4+CD44+ T cells. Bars represent the mean of the group, with vertical line indicating SD. Groups were compared for each cytokine using one-way ANOVA with Bonferroni\u0027s multiple comparison test, with * p \u003c0.05, **** p \u003c0.0001 versus ID93 alone; (B) percent of polyfunctional ID93-specific CD4+CD44+CD154+ T cells producing one or more cytokines; cytokine producing subsets are shown as stacked bars, with mean + SD of each subset. Comparisons between groups were performed using one-way ANOVA with Bonferroni\u0027s multiple comparison test, * p \u003c0.05, **** p \u003c0.0001; (C) bacterial burden in the lung is represented as Log 10 colony forming units (CFU) 3 weeks after challenge with Mtb H37Rv, with individual mice and mean +/- SD shown. Comparisons between groups were performed using one-way ANOVA with Bonferroni\u0027s multiple comparison test, * p \u003c0.05, ** p \u003c0.01, **** p \u003c0.0001 versus Saline; ^ p \u003c0.05, ^^ p \u003c0.01, ^^^^ p \u003c0.0001 versus ID93.','shortDescription':'10.1371/journal.pone.0247990.g006 Fig 6 Prophylactic protection with ID93+GLA-SE and ID93+GLA-LSQ in C57BL/6 mice. Mice were immunized with ID93 combined with different adjuvant formulations including SE, LS (liposomes), LSQ (liposomes+QS21), GLA-LS, GLA-LSQ, or GLA-SE. (A) The percent frequency of single-cytokine producing ID93-specific CD4+CD44+ T cells. Bars represent the mean of the group, with vertical... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 13, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15148_pone.0247990.g006.jpg','benchSciPubmedId':'33705411'},{'sku':'17-0441-82','imageId':'931346','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15148_pone.0247990.g007.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15148_pone.0247990.g007.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15148_pone.0247990.g007.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15148_pone.0247990.g007.jpg?time\u003d20240507','sortOrder':'55','description':'10.1371/journal.pone.0247990.g007 Fig 7 Enhanced TH1 immune responses following infection with Mtb H37Rv within the lungs of C57BL/6 mice immunized with ID93+GLA-SE and ID93+GLA-LSQ. Mice were immunized with ID93 combined with different adjuvant formulations including SE, LS (liposomes), LSQ (liposomes+QS21), GLA-LS, GLA-LSQ, or GLA-SE. Four weeks after the last immunization mice were challenged with a low dose aerosol of Mtb H37Rv. Three weeks after challenge mice were euthanized and lungs collected to assess the immune response. (A) The percent frequency of single-cytokine producing ID93-specific CD4+CD44+ T cells within the lung. Bars represent the mean of the group, with vertical line indicating SD. Groups were compared using one-way ANOVA with Bonferroni\u0027s multiple comparison test, * p \u003c0.05, ** p \u003c0.01, *** p \u003c0.001, **** p \u003c0.0001 versus ID93 alone; (B) percent of polyfunctional ID93-specific CD4+CD44+CD154+ T cells within the lung producing one or more cytokines; cytokine producing subsets are shown as stacked bars, with mean + SD of each subset. Comparisons between groups were performed using one-way ANOVA with Bonferroni\u0027s multiple comparison test, *** p \u003c0.001, **** p \u003c0.0001.','shortDescription':'10.1371/journal.pone.0247990.g007 Fig 7 Enhanced TH1 immune responses following infection with Mtb H37Rv within the lungs of C57BL/6 mice immunized with ID93+GLA-SE and ID93+GLA-LSQ. Mice were immunized with ID93 combined with different adjuvant formulations including SE, LS (liposomes), LSQ (liposomes+QS21), GLA-LS, GLA-LSQ, or GLA-SE. Four weeks after the last immunization mice were challenged with a low ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 13, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15148_pone.0247990.g007.jpg','benchSciPubmedId':'33705411'},{'sku':'17-0441-82','imageId':'931283','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15148_pone.0247990.g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15148_pone.0247990.g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15148_pone.0247990.g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15148_pone.0247990.g003.jpg?time\u003d20240507','sortOrder':'56','description':'10.1371/journal.pone.0247990.g003 Fig 3 Enhanced protection against Mtb HN878 in CB6F1 mice with liposomal formulations. (A) Increased polyfunctional ID93-specific CD4+CD44+ T cells from the spleens of immunized CB6F1 mice four weeks after the final immunization. The data are represented as the percentage of CD4+CD44+CD154+ T cells producing one or more cytokines following ex-vivo stimulation with ID93; cytokine producing subsets are shown as stacked bars, with mean + SD of each subset. Comparisons of total cytokine producing cells between groups were performed using one-way ANOVA with Bonferroni\u0027s multiple comparison test. Down-inflected lines indicate * p \u003c0.05 versus ID93+GLA-LSQ2 or ID93+GLA-LSQ3. (B) Four weeks after LDA infection with Mtb HN878, lungs were taken, and bacterial burden was determined. Bacterial load within the lung is represented as Log 10 colony forming units (CFU), with individual mice and mean +/- SD shown. Comparisons among groups were performed using one-way ANOVA with Bonferroni\u0027s multiple comparison test, * p \u003c0.05, ** p \u003c0.01, *** p \u003c0.001, **** p \u003c0.0001 versus Saline; ^ p \u003c0.05, ^^ p \u003c0.01, ^^^ p \u003c0.001 versus BCG.','shortDescription':'10.1371/journal.pone.0247990.g003 Fig 3 Enhanced protection against Mtb HN878 in CB6F1 mice with liposomal formulations. (A) Increased polyfunctional ID93-specific CD4+CD44+ T cells from the spleens of immunized CB6F1 mice four weeks after the final immunization. The data are represented as the percentage of CD4+CD44+CD154+ T cells producing one or more cytokines following ex-vivo stimulation with ID93; cyt... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 13, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15148_pone.0247990.g003.jpg','benchSciPubmedId':'33705411'},{'sku':'17-0441-82','imageId':'854860','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9883_ijms-22-01546-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9883_ijms-22-01546-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9883_ijms-22-01546-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9883_ijms-22-01546-g001.jpg?time\u003d20240507','sortOrder':'57','description':'Figure 1 Characterization of bone marrow-derived mesenchymal stem cells (MSC) isolated from mTmG mice. ( A ) Plastic adherent cells were ex vivo expanded until passage 10, maintaining red fluorescent (RFP) expression throughout. ( B ) MSCs differentiated into osteogenic (alizarin red staining), adipogenic (oil red staining), and chondrogenic (alcian blue staining) lineages. Scale bars represent 200 um. ( C ) Flow cytometry analysis for immunophenotyping showed that MSCs, in passages 7-8, were positive for CD 29 (98.8%), SCA-1 (98.2%), CD 44 (6.02%), CD 90 (4.18%), and CD 105 (4.97%), and negative for CD34 (0.49%), CD 45 (1.37%), and CD 31 (0.05%).','shortDescription':'Figure 1 Characterization of bone marrow-derived mesenchymal stem cells (MSC) isolated from mTmG mice. ( A ) Plastic adherent cells were ex vivo expanded until passage 10, maintaining red fluorescent (RFP) expression throughout. ( B ) MSCs differentiated into osteogenic (alizarin red staining), adipogenic (oil red staining), and chondrogenic (alcian blue staining) lineages. Scale bars represent 200 um. ( C ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Feb 4, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of molecular sciences','journalText':'International journal of molecular sciences 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9883_ijms-22-01546-g001.jpg','benchSciPubmedId':'33557007'},{'sku':'17-0441-82','imageId':'931178','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14873_nihms-1642142-f0002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14873_nihms-1642142-f0002.jpg?time\u003d20240507','sortOrder':'58','description':'Figure 2. Ectopic expression of NIK prevents T cell exhaustion and promotes antitumor immunity. a-c , Tumor growth curve ( a ), image of day 32 tumors ( b ), and survival curve ( c ) of the MC38-bearing NIK iTg and wildtype control mice. d , e , Tumor growth ( d ) and survival ( e ) curves of NIK iTg and wildtype control mice injected s.c. with 5 x 10 5 B16F10 melanoma cells. f , g , Flow cytometric analysis of the frequency and absolute cell number of CD4 + and CD8 + T cells ( f ) and IFN-gamma-producing CD8 + effector T cells ( g ) in day-32 tumor of MC38-bearing NIK iTg and wildtype control mice ( f , g , n\u003d6 per genotype). h-j , Flow cytometric analysis of the frequency and absolute cell number of CD4 + and CD8 + T cells in the draining lymph node ( h ) and CD44 + CXCR3 + CD8 + effector T cells in the draining lymph node ( i ) or tumor ( j ) of day-32 MC38-implanted NIK iTg and wildtype control mice ( h , n\u003d6 per group; i , n\u003d4 per group; j , n\u003d3 per group). k , l , Flow cytometric analysis of the frequency and absolute cell number of PD1 + Tim3 + and PD1 + Tim3 - CD8 + T cells ( k ) and IFN-gamma-producing gated PD1 + Tim3 + CD8 + T cells ( l ) in day-32 tumor of the MC38-bearing wildtype or iTg mice ( k , l , n\u003d6 per genotype). m , n , Flow cytometry ( m ) and qRT-PCR ( n ) analyses of PD1 and Tim3 expression level in tumor-infiltrating PD1 + Tim3 + CD8 + T cells of MC38-bearing (day 32) wildtype or iTg mice ( n , WT: n\u003d2; NIK iTg : n\u003d3) . o , Schematic of experimental','shortDescription':'Figure 2. Ectopic expression of NIK prevents T cell exhaustion and promotes antitumor immunity. a-c , Tumor growth curve ( a ), image of day 32 tumors ( b ), and survival curve ( c ) of the MC38-bearing NIK iTg and wildtype control mice. d , e , Tumor growth ( d ) and survival ( e ) curves of NIK iTg and wildtype control mice injected s.c. with 5 x 10 5 B16F10 melanoma cells. f , g , Flow cytometric analysi... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature immunology','journalText':'Nature immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14873_nihms-1642142-f0002.jpg','benchSciPubmedId':'33398181'},{'sku':'17-0441-82','imageId':'931220','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0009.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0009.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14873_nihms-1642142-f0009.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14873_nihms-1642142-f0009.jpg?time\u003d20240507','sortOrder':'59','description':'Extended Data Fig. 1 NIK regulates T cell exhaustion and antitumor immunity a, genotyping PCR of R26Stop FL Map3k14 (Map3k14 Tg ), Map3k14 +/+ CreER, and R26Stop FL Map3k14 -CreER ( Map3k14 Tg CreER) mice, showing the PCR products of NIK-GFP in Map3k14 Tg allele and CreER. b, Immunoblot analysis of NIK expression in tamoxifen-treated Map3k14 +/+ CreER (WT) and Map3k14 Tg CreER (iTg) mice. c, Schematic of experimental design for producing B16F10 tumor-bearing NIK iTg and WT control mice. Each mouse was injected s.c. with 5 x 10 5 B16F10 cells (WT\u003d9, iTg\u003d7). d,e, Flow cytometric analysis of the frequency and absolute cell number of CD4 and CD8 T cells in the tumor (d) or draining lymph node (e) of day 18 B16F10 tumor-implanted NIK-iTg and WT mice ( d , WT: n\u003d4; iTg: n\u003d5; e , n\u003d6 per genotype). f,g, Flow cytometric analysis of the frequency and absolute number of CD44 + CXCR3 + CD8 effector T cells in the draining lymph node ( f ) or tumor ( g ) of day 18 B16F10 tumor-implanted NIK-iTg and wildtype mice ( f , n\u003d6 per genotype; g, n\u003d4 per genotype). h,i, Flow cytometric analysis of the frequency and absolute number of PD1 + Tim3 + CD8 + T cells ( h ) or IFNgamma-producing PD1 + Tim3 + CD8 T cells ( i ) in the tumor of day 18 B16F10-implanted NIK iTg and wildtype control mice (h,i, n\u003d4 per genotype). Data are representative of three independent experiments. Summary data are shown as mean +- s.e.m. with P values determined by two-tailed Student\u0027s t test.','shortDescription':'Extended Data Fig. 1 NIK regulates T cell exhaustion and antitumor immunity a, genotyping PCR of R26Stop FL Map3k14 (Map3k14 Tg ), Map3k14 +/+ CreER, and R26Stop FL Map3k14 -CreER ( Map3k14 Tg CreER) mice, showing the PCR products of NIK-GFP in Map3k14 Tg allele and CreER. b, Immunoblot analysis of NIK expression in tamoxifen-treated Map3k14 +/+ CreER (WT) and Map3k14 Tg CreER (iTg) mice. c, Schematic of ex... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature immunology','journalText':'Nature immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14873_nihms-1642142-f0009.jpg','benchSciPubmedId':'33398181'},{'sku':'17-0441-82','imageId':'931199','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14873_nihms-1642142-f0006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14873_nihms-1642142-f0006.jpg?time\u003d20240507','sortOrder':'60','description':'Figure 6. HK2 deletion blocks the autoimmune phenotype of NIK tTg mice. a, Body weight of 36-day old wildtype (WT), NIK tTg (tTg), and NIK tTg Hk tKO (tTg-tKO) littermate mice (WT: n\u003d5, tTg: n\u003d8, tTg-tKO: n\u003d7) . b , Image of inguinal lymph nodes and thymi of four pairs of mice with the indicated genotypes. c , H\u0026E staining of colon and lung sections from moribund NIK tTg , NIK tTg Hk tKO and age-matched littermate wildtype control mice were assessed for leukocyte infiltrates by hematoxylin-eosin stain. Scale bars: 100 mum. (n\u003d3 in each group). d-g , Flow cytometric analysis of the frequency and absolute cell number of double-negative (DN), double-positive (DP), CD8 + single-positive (SP), and CD4 + SP thymocytes ( d ), thymic CD25 + foxp3 + T reg cells ( e ), lymph node CD25 + foxp3 + T reg cells ( f ), and lymph node CD44 - foxp3 + T reg cells ( g ) in NIK tTg , NIK tTg Hk tKO or wildtype mice ( e-f , NIK iTg : n\u003d6, NIK tTg Hk tKO : n\u003d4, wildtype: n\u003d5). Data are representative of two ( a-c , e-g ) or three ( d ) independent experiments. Summary data are shown as mean +- s.e.m. with P values determined by two-tailed Student\u0027s t test ( a , d-g ) .','shortDescription':'Figure 6. HK2 deletion blocks the autoimmune phenotype of NIK tTg mice. a, Body weight of 36-day old wildtype (WT), NIK tTg (tTg), and NIK tTg Hk tKO (tTg-tKO) littermate mice (WT: n\u003d5, tTg: n\u003d8, tTg-tKO: n\u003d7) . b , Image of inguinal lymph nodes and thymi of four pairs of mice with the indicated genotypes. c , H\u0026E staining of colon and lung sections from moribund NIK tTg , NIK tTg Hk tKO and age-matched lit... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature immunology','journalText':'Nature immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14873_nihms-1642142-f0006.jpg','benchSciPubmedId':'33398181'},{'sku':'17-0441-82','imageId':'931136','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15146_cells-09-02669-g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15146_cells-09-02669-g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15146_cells-09-02669-g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15146_cells-09-02669-g002.jpg?time\u003d20240507','sortOrder':'61','description':'Figure 2 Stemness markers of monolayers and spheroids from RT112 and 5637 cells. ( a - c ) Median fluorescence intensity of Aldefluor TM ( a ), CD44 ( b ) and CD133 ( c ) by flow cytometry analysis on RT112 and 5637 cells grown as monolayers. Results are the mean of two ( a ) and three ( b , c ) experimental replicates. Statistical test: t -test, * for p \u003c 0.05. ( d ) Representative images from confocal immunofluorescence (IF) microscopy of RT112 and 5637 cells using SOX2 Antibody (red) and Hoechst 33342 (blue) for nuclei. Cells were grown as monolayer or spheroids on different (Tissue culture-treated, Not-treated or Cell repellent) supports, before being seeded in adherent condition on chamber slides for IF.','shortDescription':'Figure 2 Stemness markers of monolayers and spheroids from RT112 and 5637 cells. ( a - c ) Median fluorescence intensity of Aldefluor TM ( a ), CD44 ( b ) and CD133 ( c ) by flow cytometry analysis on RT112 and 5637 cells grown as monolayers. Results are the mean of two ( a ) and three ( b , c ) experimental replicates. Statistical test: t -test, * for p \u003c 0.05. ( d ) Representative images from confocal imm... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 11, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cells','journalText':'Cells 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15146_cells-09-02669-g002.jpg','benchSciPubmedId':'33322565'},{'sku':'17-0441-82','imageId':'931124','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15136_13287_2020_2047_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15136_13287_2020_2047_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15136_13287_2020_2047_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15136_13287_2020_2047_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'62','description':'Fig. 1 Cell type-dependent levels of 5-methylcytosine and 5-hydroxymethylcytosine. a Representative fluorescent micrographs for canine fetal fibroblasts (cFFs) stained with phycoerythin (PE)-conjugated antibodies against CD44 and CD90/THY1. Scale bar unit length is 50 mum. b Overlay histograms showing cFFs stained with PE-conjugated antibodies (red) or isotype control antibodies (black). Fold difference in c 5-methylcytosine and d 5-hydroxymethylcyctosine levels in canine adult fibroblast (cAF), canine fetal fibroblast (cFF), canine partially reprogrammed (cPR), and canine embryonic stem cells (cESCs). Data are presented as mean +- standard error, n \u003d 4. Relative transcript abundance for e TET1, f TET2, and g TET3 in steady-state cultures of cAF and cFF. Data are presented as mean +- standard error, n \u003d 3. Means annotated with different letters are considered significantly different by one-way analysis of variance and Tukey\u0027s honestly squared difference test, P \u003c 0.05','shortDescription':'Fig. 1 Cell type-dependent levels of 5-methylcytosine and 5-hydroxymethylcytosine. a Representative fluorescent micrographs for canine fetal fibroblasts (cFFs) stained with phycoerythin (PE)-conjugated antibodies against CD44 and CD90/THY1. Scale bar unit length is 50 mum. b Overlay histograms showing cFFs stained with PE-conjugated antibodies (red) or isotype control antibodies (black). Fold difference in ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 9, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Stem cell research \u0026 therapy','journalText':'Stem cell research \u0026 therapy 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15136_13287_2020_2047_Fig1_HTML.jpg','benchSciPubmedId':'33298190'},{'sku':'17-0441-82','imageId':'931107','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19120_41419_2020_3219_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19120_41419_2020_3219_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19120_41419_2020_3219_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19120_41419_2020_3219_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'63','description':'Fig. 3 EZH2 deficiency in DCs inhibited the CD4 + T-cell response during bacteria-induced liver injury. Ezh2 D-/- mice and WT mice were injected intravenously with P.ac suspended in PBS. The peripheral blood, liver, or spleen were isolated from naive, Ezh2 D-/- mice and WT mice on day 7. Statistical analyses of the numbers of A MNCs isolated from livers and spleens and B the CD4 + T-cell percentage of MNCs are shown. C The levels of CXCR3 and CCR7 expressed on CD4 + T cells were analyzed by flow cytometry. D The levels of CD44 and CD62L on CD4 + T cells were analyzed by flow cytometry. E The levels of serum IFN-gamma, IL-5, and IL-17 were measured by enzyme-linked immunosorbent assay ( n \u003d 8 mice per group). F The production of the inflammatory cytokine IFN-gamma by CD4 + T cells was assessed by intracellular staining and analyzed by flow cytometry. Representative dot plots are shown. G MNCs isolated from livers and spleens were stained for CD4 and Foxp3 and analyzed by flow cytometry. Data are shown as the mean +- SEM of three independent experiments. * P \u003c 0.05.','shortDescription':'Fig. 3 EZH2 deficiency in DCs inhibited the CD4 + T-cell response during bacteria-induced liver injury. Ezh2 D-/- mice and WT mice were injected intravenously with P.ac suspended in PBS. The peripheral blood, liver, or spleen were isolated from naive, Ezh2 D-/- mice and WT mice on day 7. Statistical analyses of the numbers of A MNCs isolated from livers and spleens and B the CD4 + T-cell percentage of MNCs ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19120_41419_2020_3219_Fig3_HTML.jpg','benchSciPubmedId':'33262329'},{'sku':'17-0441-82','imageId':'931157','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14883_gr2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14883_gr2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14883_gr2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14883_gr2.jpg?time\u003d20240507','sortOrder':'64','description':'Figure 2 NK Cells Contribute to Both Innate and Adaptive Immune Control of Ptgs -/- Tumors (A) Growth profile of Ptgs +/+ and Ptgs -/- melanoma cells implanted into Rag1 -/- or wild-type mice untreated or depleted of NK, CD4 + , and/or CD8 + cells. (B and C) Frequency of CD8 + T cells (B); representative plots and frequency of CD8 + CD44 + , CD8 + IFNgamma + , and CD4 + IFNgamma + T cells (C) gated on live, CD45 + , CD3epsilon + cells in Ptgs +/+ and Ptgs -/- untreated or NK cell-depleted wild-type mice analyzed 7 days post-implantation. (D) Individual growth profiles of Ptgs -/- melanoma cells in wild-type mice depleted of NK cells from the day before or a week after cancer cell implantation. (E) Growth profile of Ptgs +/+ and Ptgs -/- cells in wild-type mice or Ptgs +/+ cells in GPP mice. (F) Tumor weight, NK cell frequency, and number per g of tumor analyzed 4 days after implantation of Ptgs +/+ and Ptgs -/- cells in wild-type or Ptgs +/+ cells in GPP mice. (G) Growth profile of Ptgs +/+ and Ptgs -/- melanoma cells in wild-type or Ptgs +/+ melanoma cells in Ptger2 -/- or Gzmb-Cre Ptger4 floxed/floxed mice. Data are expressed as mean +- SEM, one-way (B-C and F) or two-way ANOVA (A).','shortDescription':'Figure 2 NK Cells Contribute to Both Innate and Adaptive Immune Control of Ptgs -/- Tumors (A) Growth profile of Ptgs +/+ and Ptgs -/- melanoma cells implanted into Rag1 -/- or wild-type mice untreated or depleted of NK, CD4 + , and/or CD8 + cells. (B and C) Frequency of CD8 + T cells (B); representative plots and frequency of CD8 + CD44 + , CD8 + IFNgamma + , and CD4 + IFNgamma + T cells (C) gated on live,... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 15, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Immunity','journalText':'Immunity 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14883_gr2.jpg','benchSciPubmedId':'33220234'},{'sku':'17-0441-82','imageId':'931065','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15134_elife-56934-fig3.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15134_elife-56934-fig3.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15134_elife-56934-fig3.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15134_elife-56934-fig3.jpg?time\u003d20240507','sortOrder':'65','description':'Figure 3. RNAseq of WNK1-deficient thymocytes reveals significant changes in five distinct processes. ( A ) Thymi were harvested from Wnk1 fl/+ Rag1 -/- CD2-Cre and Wnk1 fl/fl Rag1 -/- CD2-Cre mice that were either untreated (0 hr) or had been injected with anti-CD3epsilon antibody 3, 24 or 48 hr earlier. DN3+DN4 thymocytes were sorted, RNA purified and analyzed by RNAseq, results of which are shown in C-E. ( B ) Flow cytometric analysis of DN thymocytes from the experiment described in A. Gates indicate cells (Thy1.2 + , CD44 - ) that were sorted for further RNAseq analysis. ( C ) Principal component analysis using expression of all normalized genes for all samples from the experiment described in A. ( D ) Log 2 fold changes and total number of statistically significant differentially expressed genes (DEGs) in samples from Wnk1 fl/fl Rag1 -/- CD2-Cre (KO) mice compared to Wnk1 fl/+ Rag1 -/- CD2-Cre (HET) mice at each time point ( Supplementary files 2 , 3 ). ( E ) Metacore process analysis of DEGs. Selected processes and their P -values are shown at each time point; graph on left shows the lowest P -value for each process from any of the four time points. Red bars indicate time point with the lowest P -values for each process (Minimal). Ratios indicate the number of DEGs at each time point over the number of all genes in the indicated processes. Significance calculated by Wald\u0027s test ( D ) and Hypergeometric test ( E ). Sample sizes: three Wnk1 fl/+ Rag1 -/- CD2-Cre and four','shortDescription':'Figure 3. RNAseq of WNK1-deficient thymocytes reveals significant changes in five distinct processes. ( A ) Thymi were harvested from Wnk1 fl/+ Rag1 -/- CD2-Cre and Wnk1 fl/fl Rag1 -/- CD2-Cre mice that were either untreated (0 hr) or had been injected with anti-CD3epsilon antibody 3, 24 or 48 hr earlier. DN3+DN4 thymocytes were sorted, RNA purified and analyzed by RNAseq, results of which are shown in C-E.... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 14, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15134_elife-56934-fig3.jpg','benchSciPubmedId':'33051000'},{'sku':'17-0441-82','imageId':'931044','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15134_elife-56934-fig2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15134_elife-56934-fig2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15134_elife-56934-fig2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15134_elife-56934-fig2.jpg?time\u003d20240507','sortOrder':'66','description':'Figure 2. WNK1 is required for thymocytes to develop past the pre-TCR checkpoint. ( A ) Left: flow cytometric analysis of Thy1.2 + Lineage - thymocytes separated by expression of CD44 and CD25, and then DN3 (CD44 - CD25 + ) cells separated into DN3a (small, FSC low CD28 - ) and DN3b (large, FSC high CD28 + ) cells. Right: Mean +- SEM cell numbers in DN subsets. ( B ) Left: Flow cytometric analysis of thymocytes from Wnk1 fl/+ CD2-Cre and Wnk1 fl/fl CD2-Cre mice showing intracellular TCRbeta levels in DN2+DN3 and DN4 subsets. Numbers indicate the percentage of TCRbeta + cells. Right: Mean +- SEM percentage of DN2+DN3 and DN4 cells that are intracellular TCRbeta + . ( C ) Mean +- SEM of CD3epsilon or pre-Talpha surface levels measured as mean fluorescence intensity (MFI) in flow cytometry of DN2+DN3 and DN4 thymocytes from Wnk1 fl/+ CD2-Cre and Wnk1 fl/fl CD2-Cre mice. ( D ) Left: flow cytometric analysis of CD4 and CD8 levels on thymocytes from Wnk1 fl/+ Rag1 -/- CD2-Cre and Wnk1 fl/fl Rag1 -/- CD2-Cre mice harvested 4 d after intraperitoneal injection with PBS or anti-CD3epsilon antibody. Gate indicates DP thymocytes and number shows percentage of cells in the gate. Right: mean +- SEM number of DP thymocytes defined using the gates on the left. *0.01\u003cp\u003c0.05, and **p\u003c0.01. Significance calculated by Mann-Whitney test. Sample sizes: six of each genotype ( A, B ), eight Wnk1 fl/+ CD2-Cre and ten Wnk1 fl/fl CD2-Cre mice ( C ), four Wnk1 fl/+ Rag1 -/- CD2-Cre and Wnk1 fl/fl Rag1 -','shortDescription':'Figure 2. WNK1 is required for thymocytes to develop past the pre-TCR checkpoint. ( A ) Left: flow cytometric analysis of Thy1.2 + Lineage - thymocytes separated by expression of CD44 and CD25, and then DN3 (CD44 - CD25 + ) cells separated into DN3a (small, FSC low CD28 - ) and DN3b (large, FSC high CD28 + ) cells. Right: Mean +- SEM cell numbers in DN subsets. ( B ) Left: Flow cytometric analysis of thymoc... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 14, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15134_elife-56934-fig2.jpg','benchSciPubmedId':'33051000'},{'sku':'17-0441-82','imageId':'931023','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15134_elife-56934-fig1.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15134_elife-56934-fig1.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15134_elife-56934-fig1.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15134_elife-56934-fig1.jpg?time\u003d20240507','sortOrder':'67','description':'Figure 1. Essential role for WNK1 in thymocyte development. ( A ) Flow cytometric analysis of thymocytes from Wnk1 fl/+ CD2-Cre and Wnk1 fl/fl CD2-Cre mice showing double negative (DN, Thy1.2 + Lineage - ) thymocytes subdivided into DN1 (CD44 + CD25 - ), DN2+DN3 (CD25 + ), and DN4 (CD44 - CD25 - ) subsets, immature single positive (ISP, CD4 - CD8 + TCRbeta - ), double positive (DP, CD4 + CD8 + ), CD4 + single positive (4SP, CD4 + CD8 - ), and CD8 + single positive (8SP, CD4 - CD8 + TCRbeta + ) thymocytes. Numbers show % of cells falling into each gate. ( B ) Mean +- SEM number of total thymocytes and of thymocytes at each developmental stage defined using the gates in A, as well as gammadelta thymocytes (CD4 - TCRgamma + ). ( C ) Mean +- SEM number of cells in each thymocyte population in Wnk1 fl/fl CD2-Cre animals normalized to Wnk1 fl/+ CD2-Cre controls (set to 100%). ( D ) Mean +- SEM Wnk1 mRNA levels in thymic subsets from Wnk1 fl/+ CD2-Cre and Wnk1 fl/fl CD2-Cre mice, normalized to Wnk1 fl/+ CD2-Cre controls (set to 100%) measured by Q-PCR from exon 1 to exon 2. CD44 levels were used to separate DN2 (CD44 + ) and DN3 (CD44 - ) thymocytes. ( E ) Flow cytometric analysis of Rag1 -/- radiation chimeras reconstituted with bone marrow from Wnk1 fl/+ RCE and Wnk1 fl/D368A RCE mice, treated with tamoxifen and analyzed 7 d later showing gating for thymocyte subsets as in A, with DN (Thy1.2 + Lineage - ) thymocytes pre-gated on CD4 - CD8 - cells. ( F ) Mean +- SEM number of cells','shortDescription':'Figure 1. Essential role for WNK1 in thymocyte development. ( A ) Flow cytometric analysis of thymocytes from Wnk1 fl/+ CD2-Cre and Wnk1 fl/fl CD2-Cre mice showing double negative (DN, Thy1.2 + Lineage - ) thymocytes subdivided into DN1 (CD44 + CD25 - ), DN2+DN3 (CD25 + ), and DN4 (CD44 - CD25 - ) subsets, immature single positive (ISP, CD4 - CD8 + TCRbeta - ), double positive (DP, CD4 + CD8 + ), CD4 + sing... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 14, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15134_elife-56934-fig1.jpg','benchSciPubmedId':'33051000'},{'sku':'17-0441-82','imageId':'930989','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15133_CTM2-10-e139-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15133_CTM2-10-e139-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15133_CTM2-10-e139-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15133_CTM2-10-e139-g001.jpg?time\u003d20240507','sortOrder':'68','description':'FIGURE 1 Characterization of colorectal CSCs isolated from LoVo and HT29 cells. A, Flow cytometric sorting of CSCs using CD44 and EpCAM as markers. The percentage of parental LoVo and HT29 cells expressing both CD44 and EpCAM was approximately 15%, representing the proportion of CSCs. CSCs isolated from parental LoVo and HT29 cells (denoted as LoVo-CSCs and HT29-CSCs, respectively) exhibited high expression of both markers (\u003e90%). Relative proliferation of (B) LoVo-CSCs and (C) HT29-CSCs was inhibited by ATL-1 at 200 muM for up to 72 h, compared to that of control (+PBS) CSCs. The protein expression of stemness markers OCT-4, SOX-9, and Nanog, relative to GAPDH, in (D) LoVo-CSCs and (E) HT29-CSCs was downregulated by ATL-1 at 200 muM after 48 h of culture, compared to that of control (+PBS) CSCs. Transwell assay of the (F) migration and (G) invasion of LoVo-CSCs demonstrated decreased cell counts in both cases when ATL-1 was administered at 200 muM, compared to those of control (+PBS) CSCs. H, The percentage of apoptotic LoVo-CSCs and HT29-CSCs was elevated in the presence of ATL-1 at 200 muM, compared to that of control (+PBS) CSCs. The data represent the mean +- SD of three independent technical replicates ( t -test); * P \u003c .05; % P \u003c .05 at 72 h','shortDescription':'FIGURE 1 Characterization of colorectal CSCs isolated from LoVo and HT29 cells. A, Flow cytometric sorting of CSCs using CD44 and EpCAM as markers. The percentage of parental LoVo and HT29 cells expressing both CD44 and EpCAM was approximately 15%, representing the proportion of CSCs. CSCs isolated from parental LoVo and HT29 cells (denoted as LoVo-CSCs and HT29-CSCs, respectively) exhibited high expression... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Clinical and translational medicine','journalText':'Clinical and translational medicine 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15133_CTM2-10-e139-g001.jpg','benchSciPubmedId':'32898324'},{'sku':'17-0441-82','imageId':'930381','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15121_urn-x-wiley-20011326-media-ctm2139-ctm2139-fig-0001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15121_urn-x-wiley-20011326-media-ctm2139-ctm2139-fig-0001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15121_urn-x-wiley-20011326-media-ctm2139-ctm2139-fig-0001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15121_urn-x-wiley-20011326-media-ctm2139-ctm2139-fig-0001.jpg?time\u003d20240507','sortOrder':'69','description':'1 FIGURE Characterization of colorectal CSCs isolated from LoVo and HT29 cells. A, Flow cytometric sorting of CSCs using CD44 and EpCAM as markers. The percentage of parental LoVo and HT29 cells expressing both CD44 and EpCAM was approximately 15%, representing the proportion of CSCs. CSCs isolated from parental LoVo and HT29 cells (denoted as LoVo-CSCs and HT29-CSCs, respectively) exhibited high expression of both markers (\u003e90%). Relative proliferation of (B) LoVo-CSCs and (C) HT29-CSCs was inhibited by ATL-1 at 200 muM for up to 72 h, compared to that of control (+PBS) CSCs. The protein expression of stemness markers OCT-4, SOX-9, and Nanog, relative to GAPDH, in (D) LoVo-CSCs and (E) HT29-CSCs was downregulated by ATL-1 at 200 muM after 48 h of culture, compared to that of control (+PBS) CSCs. Transwell assay of the (F) migration and (G) invasion of LoVo-CSCs demonstrated decreased cell counts in both cases when ATL-1 was administered at 200 muM, compared to those of control (+PBS) CSCs. H, The percentage of apoptotic LoVo-CSCs and HT29-CSCs was elevated in the presence of ATL-1 at 200 muM, compared to that of control (+PBS) CSCs. The data represent the mean +- SD of three independent technical replicates ( t -test); * P \u003c .05; % P \u003c .05 at 72 h','shortDescription':'1 FIGURE Characterization of colorectal CSCs isolated from LoVo and HT29 cells. A, Flow cytometric sorting of CSCs using CD44 and EpCAM as markers. The percentage of parental LoVo and HT29 cells expressing both CD44 and EpCAM was approximately 15%, representing the proportion of CSCs. CSCs isolated from parental LoVo and HT29 cells (denoted as LoVo-CSCs and HT29-CSCs, respectively) exhibited high expression... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Clinical and translational medicine','journalText':'Clinical and translational medicine 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15121_urn-x-wiley-20011326-media-ctm2139-ctm2139-fig-0001.jpg','benchSciPubmedId':'32898324'},{'sku':'17-0441-82','imageId':'930968','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19118_cells-09-01707-g005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19118_cells-09-01707-g005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19118_cells-09-01707-g005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19118_cells-09-01707-g005.jpg?time\u003d20240507','sortOrder':'70','description':'Figure 5 Comparative analysis of SCESM spheroids and multi-cellular tumor spheroids (MCTSs). ( a ) Graph representing SCESM spheroid and MCTS mean diameter increase. Spheroids were photographed on days 2, 4, and 7 and representative phase-contrast microscope images of SCESM spheroids and MCTSs on days 2, 4, and 7 are displayed under the graph. Mean values +- SE ( n \u003e\u003d 8) are presented. Scale bars correspond to 400 um; ( b - e ) Protein expression of four different stem markers was assessed in SCESM spheroids and MCTSs by flow cytometry. Normalized fluorescence intensities of selected proteins are presented and corresponding flow cytometry visible light and fluorescent photos are attached ( n \u003e\u003d 5, N \u003e\u003d 2000); (b) CD44 protein expression; ( c ) CD73 protein expression; ( d ) CD90 protein expression; ( e ) CD133 protein expression; ( f ) OCT4 and tubulin protein expressions were assessed in SCESM spheroids and MCTSs by Western blot analysis. Western blot membrane photo showing OCT4 and tubulin and graph depicting normalized OCT4 protein expression analysis from Western blots (using Image Lab software) are presented ( n \u003e\u003d 3); ( g - i ) Relative gene expression of three additional stem markers assessed in 7-day-old MCTSs and SCESM spheroids; Normalized mean values +- SE ( n \u003e\u003d 5) are presented; ( g ) Relative gene expression of ALDH1A1 ; ( h ) Relative gene expression of NANOG ; ( i ) Relative gene expression of SOX2 . (* p \u003c 0.05, **** p \u003c 0.0001 vs. control (MCTS)). B: blank;','shortDescription':'Figure 5 Comparative analysis of SCESM spheroids and multi-cellular tumor spheroids (MCTSs). ( a ) Graph representing SCESM spheroid and MCTS mean diameter increase. Spheroids were photographed on days 2, 4, and 7 and representative phase-contrast microscope images of SCESM spheroids and MCTSs on days 2, 4, and 7 are displayed under the graph. Mean values +- SE ( n \u003e\u003d 8) are presented. Scale bars correspond... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jul 16, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cells','journalText':'Cells 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19118_cells-09-01707-g005.jpg','benchSciPubmedId':'32708734'},{'sku':'17-0441-82','imageId':'930947','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19118_cells-09-01707-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19118_cells-09-01707-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19118_cells-09-01707-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19118_cells-09-01707-g004.jpg?time\u003d20240507','sortOrder':'71','description':'Figure 4 Protein expression of stem markers. The protein expression of five different stem markers was assessed in the FaDu adherent cell line and 7-day-old SCESM spheroids by Western blot and flow cytometry. ( a - d ) Protein expression analyzed by flow cytometry. Normalized fluorescence intensities of selected proteins are presented, and corresponding flow cytometry visible light and fluorescent photos are attached. Normalized mean values +- SE ( n \u003e\u003d 5, N \u003e\u003d 2000) are presented (**** p \u003c 0.0001 vs. control (adh)); ( a ) CD44 protein expression; ( b ) CD73 protein expression; ( c ) CD90 protein expression; ( d ) CD133 protein expression; ( e ) OCT4 and tubulin protein expression analyzed by Western blot. Western blot membrane photos showing OCT4 and tubulin and a graph depicting normalized OCT4 protein expression analysis from Western blots are presented. Bars represent normalized mean values +- SE ( n \u003e\u003d 3). B: blank; adh: adherent cell line; S: SCESM.','shortDescription':'Figure 4 Protein expression of stem markers. The protein expression of five different stem markers was assessed in the FaDu adherent cell line and 7-day-old SCESM spheroids by Western blot and flow cytometry. ( a - d ) Protein expression analyzed by flow cytometry. Normalized fluorescence intensities of selected proteins are presented, and corresponding flow cytometry visible light and fluorescent photos ar... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jul 16, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cells','journalText':'Cells 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19118_cells-09-01707-g004.jpg','benchSciPubmedId':'32708734'},{'sku':'17-0441-82','imageId':'930822','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15132_13578_2020_428_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15132_13578_2020_428_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15132_13578_2020_428_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15132_13578_2020_428_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'72','description':'Fig. 1 SHP1 deficiency had no effect on the cell morphology, proliferation rate or surface markers. a Phase-contrast images of MSCs derived from bone marrow of WT and me v /me v mice. Scale bar: 50 mum. b The same number of WT and me v /me v MSCs were coated into the 6 well plates, the number were calculated every day until the sixth day and the proliferation rate was monitored. c After isolation from bone marrow and culture for an equal number of passages, me v /me v and WT MSCs were harvested and analyzed for the indicated markers by immunofluorescence staining and flow cytometry. The experiments were repeated at least three times. Error bars represent +- SEM (n \u003d 3), ns, not significant','shortDescription':'Fig. 1 SHP1 deficiency had no effect on the cell morphology, proliferation rate or surface markers. a Phase-contrast images of MSCs derived from bone marrow of WT and me v /me v mice. Scale bar: 50 mum. b The same number of WT and me v /me v MSCs were coated into the 6 well plates, the number were calculated every day until the sixth day and the proliferation rate was monitored. c After isolation from bone ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Apr 14, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell \u0026 bioscience','journalText':'Cell \u0026 bioscience 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15132_13578_2020_428_Fig1_HTML.jpg','benchSciPubmedId':'32467752'},{'sku':'17-0441-82','imageId':'930904','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15063_ijms-21-03675-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15063_ijms-21-03675-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15063_ijms-21-03675-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15063_ijms-21-03675-g001.jpg?time\u003d20240507','sortOrder':'73','description':'Figure 1 Fluorescence-activated cell sorting (FACS) analyses of mesenchymal stem cell MSC)-conjugated control isotype IgG or antibodies against indicated cell-surface proteins. MSCs were negative for CD11b, CD34, and CD45 ( A ) and positive for CD29 and CD44 ( B ).','shortDescription':'Figure 1 Fluorescence-activated cell sorting (FACS) analyses of mesenchymal stem cell MSC)-conjugated control isotype IgG or antibodies against indicated cell-surface proteins. MSCs were negative for CD11b, CD34, and CD45 ( A ) and positive for CD29 and CD44 ( B ).','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'May 23, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of molecular sciences','journalText':'International journal of molecular sciences 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15063_ijms-21-03675-g001.jpg','benchSciPubmedId':'32456187'},{'sku':'17-0441-82','imageId':'930926','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15144_cancers-12-01325-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15144_cancers-12-01325-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15144_cancers-12-01325-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15144_cancers-12-01325-g003.jpg?time\u003d20240507','sortOrder':'74','description':'Figure 3 CD44 deletion in breast cancer cell lines decreases expression of genes involved in cellular adhesion and cytokine activity. ( A ) CD44 KO was confirmed via Western blot and compared to the loading control beta-tubulin via densitometry. CD44 KO indicates that cells received gRNA targeting exons 1 and 5 of CD44. CD44 WT (CD29+/CD44+) and CD44 KO (CD29+/CD44-) cells were sorted and expanded in culture. ( B ) Venn diagram illustrating RNA sequencing results (submitted in triplicate). A total of 1530 and 320 genes were impacted by CD44 KO in the Hs578T cells and MDA-MB-231 cells, respectively. When comparing each of these data sets, 40 genes were differentially expressed in both Hs578T and MDA-MB-231 cells upon deletion of CD44. ( C ) Heat map demonstrating log fold change of differential gene expression in CD44 WT relative to CD44 KO Hs578T and MDA-MB-231 cells. ( D ) Gene ontology analysis identifying gene sets enriched in CD44 WT relative to CD44 KO Hs578T and MDA-MB-231 cells. Dot size represents the number of genes enriched within that pathway, while color represents an adjusted p -value.','shortDescription':'Figure 3 CD44 deletion in breast cancer cell lines decreases expression of genes involved in cellular adhesion and cytokine activity. ( A ) CD44 KO was confirmed via Western blot and compared to the loading control beta-tubulin via densitometry. CD44 KO indicates that cells received gRNA targeting exons 1 and 5 of CD44. CD44 WT (CD29+/CD44+) and CD44 KO (CD29+/CD44-) cells were sorted and expanded in cultur... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'May 22, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cancers','journalText':'Cancers 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15144_cancers-12-01325-g003.jpg','benchSciPubmedId':'32455980'},{'sku':'17-0441-82','imageId':'855133','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9896_urn-x-wiley-07360266-media-jor24749-jor24749-fig-0007.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9896_urn-x-wiley-07360266-media-jor24749-jor24749-fig-0007.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9896_urn-x-wiley-07360266-media-jor24749-jor24749-fig-0007.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9896_urn-x-wiley-07360266-media-jor24749-jor24749-fig-0007.jpg?time\u003d20240507','sortOrder':'75','description':'7 Figure Fracture callus TSP2 positive cells express a MSC immunophenotype. Transverse femoral fractures were induced in TSP2-GFP reporter mice. Calluses from six mice were harvested 7 days post-fracture, pooled, and digested in trypsin, collagenase A, and hyaluronidase. Cells were labeled with anti-mouse directly conjugated MSC antibodies (CD44, CD105, CD45, and Sca-1) and DAPI before flow cytometry. A, Cells were gated by size and granularity using an SSC-A/FSC-A color density plot. Single cells were sub-gated by FSC-W/FSC-A and dead (DAPI+) cells were discriminated by sub-gating on a DAPI-A/SSC-A. B, Included cells were gated by GFP-A as either T2GFP-neg (red) or T2GFP-pos (green). C, Representative histograms of cell surface markers in T2GFP-pos cells. D, Representative histograms of cell surface markers in T2GFP-neg cells. Histograms were gated for positive selection of CD44, CD105, and Sca-1 and negative selection of CD45 to match the known MSC immunophenotype of CD44+/CD105+/CD45-/Sca-1+. Flow cytometry was repeated two times with an n \u003d 2 per experiment. MSC, mesenchymal progenitor cells; TSP2, thrombospondin-2 [Color figure can be viewed at wileyonlinelibrary.com ]','shortDescription':'7 Figure Fracture callus TSP2 positive cells express a MSC immunophenotype. Transverse femoral fractures were induced in TSP2-GFP reporter mice. Calluses from six mice were harvested 7 days post-fracture, pooled, and digested in trypsin, collagenase A, and hyaluronidase. Cells were labeled with anti-mouse directly conjugated MSC antibodies (CD44, CD105, CD45, and Sca-1) and DAPI before flow cytometry. A, Ce... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jan 1, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of orthopaedic research : official publication of the Orthopaedic Research Society','journalText':'Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9896_urn-x-wiley-07360266-media-jor24749-jor24749-fig-0007.jpg','benchSciPubmedId':'32437051'},{'sku':'17-0441-82','imageId':'842698','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12759_fcell-08-00263-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12759_fcell-08-00263-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12759_fcell-08-00263-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12759_fcell-08-00263-g001.jpg?time\u003d20240507','sortOrder':'76','description':'FIGURE 1 Characterization of young and aged MSCs and exosomes. (A) Surface marker profiling of young-MSCs and aged-MSCs. (B) SA-beta-Gal staining showed that senescence increased significantly in aged MSCs. (C) Representative immunoblot images and quantitative analysis of p21, p53, and p16 protein level in young and aged-MSCs. ( n \u003d 3). (D) Quantitation of cell cycle phases by propidium iodide staining. ( n \u003d 3). (E) The CCK-8 assay showed that aged MSCs grew more slowly than young MSCs. ( n \u003d 6). (F) Young and aged exosomes were observed using TEM. (G) The exosome surface markers were analyzed by Western blot. (H) Nanoparticle tracking analysis was used to analyze the particle size and concentration of Young-Exo and Aged-Exo. * p \u003c 0.05; ** p \u003c 0.01; *** p \u003c 0.001; **** p \u003c 0.0001; NS, not significant.','shortDescription':'FIGURE 1 Characterization of young and aged MSCs and exosomes. (A) Surface marker profiling of young-MSCs and aged-MSCs. (B) SA-beta-Gal staining showed that senescence increased significantly in aged MSCs. (C) Representative immunoblot images and quantitative analysis of p21, p53, and p16 protein level in young and aged-MSCs. ( n \u003d 3). (D) Quantitation of cell cycle phases by propidium iodide staining. ( n... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Sep 28, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in cell and developmental biology','journalText':'Frontiers in cell and developmental biology 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12759_fcell-08-00263-g001.jpg','benchSciPubmedId':'32432109'},{'sku':'17-0441-82','imageId':'843231','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12843_fmicb-11-00821-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12843_fmicb-11-00821-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12843_fmicb-11-00821-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12843_fmicb-11-00821-g004.jpg?time\u003d20240507','sortOrder':'77','description':'FIGURE 4 Changes in cellular sub-populations in differentiating MPIEs. (A) CD326 (Epcam) versus CD44 expression in cells harvested at different time points. (B) Transcriptional changes of the major cell marker genes in 3 days of differentiation detected by RT-qPCR. The transcription levels were normalized to that of GAPDH and the relative fold changes were calculated using the 2 -DeltaDeltaCT . Each bar indicated means +- standard deviations for three independent trials. The abbreviations on the map are leucine-rich-repeat-containing G-protein-coupled receptor 5 ( Lgr5 ), B cell-specific moloney murine leukemia virus integration site 1 ( Bmi1 ), Ki-67 ( Ki67 ), chromogranin A ( ChgA ), trefoil factor 3 ( TFF3 ), lysozyme ( Lyz ) and fatty acid-binding protein 1 ( L-Fabp ).','shortDescription':'FIGURE 4 Changes in cellular sub-populations in differentiating MPIEs. (A) CD326 (Epcam) versus CD44 expression in cells harvested at different time points. (B) Transcriptional changes of the major cell marker genes in 3 days of differentiation detected by RT-qPCR. The transcription levels were normalized to that of GAPDH and the relative fold changes were calculated using the 2 -DeltaDeltaCT . Each bar ind... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Sep 28, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in microbiology','journalText':'Frontiers in microbiology 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12843_fmicb-11-00821-g004.jpg','benchSciPubmedId':'32390999'},{'sku':'17-0441-82','imageId':'841963','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12698_ijms-21-02722-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12698_ijms-21-02722-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12698_ijms-21-02722-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12698_ijms-21-02722-g004.jpg?time\u003d20240507','sortOrder':'78','description':'Figure 4 obASCs promote a cancer stem-like phenotype through leptin. ( A ) Transwell co-culture with shCtrl obASCs upregulates NOTCH1, NOTCH3, DELTA1, and JAGGED2 in ER + BCCs. ( B ) BCCs have increased ability to form mammospheres after co-culture with shCtrl obASCs followed by 2 Gy radiation compared to non-co-cultured cells or cells co-cultured with shLep obASCs. ( C ) Flow cytometric analysis of the breast cancer stem cell markers CD44 + CD24 - was evaluated for BCCs after transwell co-culture with shCtrl obASCs or shLep obASCs. Values reported are the mean of three independent experiments each performed in triplicate. Bars, +- SEM. * p \u003c 0.05, ** p \u003c 0.01, *** p \u003c 0.001.','shortDescription':'Figure 4 obASCs promote a cancer stem-like phenotype through leptin. ( A ) Transwell co-culture with shCtrl obASCs upregulates NOTCH1, NOTCH3, DELTA1, and JAGGED2 in ER + BCCs. ( B ) BCCs have increased ability to form mammospheres after co-culture with shCtrl obASCs followed by 2 Gy radiation compared to non-co-cultured cells or cells co-cultured with shLep obASCs. ( C ) Flow cytometric analysis of the bre... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Apr 15, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of molecular sciences','journalText':'International journal of molecular sciences 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12698_ijms-21-02722-g004.jpg','benchSciPubmedId':'32326381'},{'sku':'17-0441-82','imageId':'930801','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19114_MMR-21-06-2405-g00.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19114_MMR-21-06-2405-g00.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19114_MMR-21-06-2405-g00.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19114_MMR-21-06-2405-g00.jpg?time\u003d20240507','sortOrder':'79','description':'Figure 1. Immunophenotyping results of isolated and cultured bone marrow-derived mesenchymal stem cells. Surface markers by flow cytometry for (A) CD44, (B) CD71 and (C) CD34. CD, cluster of differentiation.','shortDescription':'Figure 1. Immunophenotyping results of isolated and cultured bone marrow-derived mesenchymal stem cells. Surface markers by flow cytometry for (A) CD44, (B) CD71 and (C) CD34. CD, cluster of differentiation.','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jun 1, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular medicine reports','journalText':'Molecular medicine reports 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19114_MMR-21-06-2405-g00.jpg','benchSciPubmedId':'32323777'},{'sku':'17-0441-82','imageId':'930871','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19116_MMR-22-01-0286-g02.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19116_MMR-22-01-0286-g02.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19116_MMR-22-01-0286-g02.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19116_MMR-22-01-0286-g02.jpg?time\u003d20240507','sortOrder':'80','description':'Figure 3. Expression of ALDH1, CD133 and CD44 prior to and following induction of differentiation in SP cells. SP or non-SP cells were incubated with anti-ALDH1, anti-CD133 and anti-CD44 antibodies together, and subjected to flow cytometry analysis. (A) Percentage of ALDH1 + , CD133 + or CD44 + cells in non-SP and SP cells prior to (day 0) and following differentiation (day 14). During flow cytometry analysis, Left, cells were analyzed for the expression of ALDH1 and CD133; Middle, cells were analyzed for the expression of ALDH1 and CD44; Right, cells were analyzed for the expression of CD133 and CD44. All these were conducted in the same population of SP or non-SP cells. (B) Percentage of only ALDH1 + cells in the same population of non-SP and SP cells in A prior to (day 0) and following differentiation (day 14). (C) Percentage of ALDH1 + cells in non-SP and SP cells prior to (day 0) and following differentiation (day 14) after three independent experiments. **P\u003c0.01. ALDH1, aldehyde dehydrogenase-1; CD44, CD44 antigen; CD133, CD133 antigen; PE, phycoerythrin; APC, allophycocyanin; SSC, side scatter; SP, side population.','shortDescription':'Figure 3. Expression of ALDH1, CD133 and CD44 prior to and following induction of differentiation in SP cells. SP or non-SP cells were incubated with anti-ALDH1, anti-CD133 and anti-CD44 antibodies together, and subjected to flow cytometry analysis. (A) Percentage of ALDH1 + , CD133 + or CD44 + cells in non-SP and SP cells prior to (day 0) and following differentiation (day 14). During flow cytometry analys... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jul 1, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular medicine reports','journalText':'Molecular medicine reports 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19116_MMR-22-01-0286-g02.jpg','benchSciPubmedId':'32319646'},{'sku':'17-0441-82','imageId':'843210','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12842_41419_2020_2435_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12842_41419_2020_2435_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12842_41419_2020_2435_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12842_41419_2020_2435_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'81','description':'Fig. 2 CCL5 promotes the invasion and the PCSCs subpopulation of prostate cancer cells in vitro. a , b CCL5 (2.5-40 ng/ml) had no obvious influences on the proliferation and colony formation capacities of the prostate cancer cell lines DU145 and PC3. c CCL5 addition (20-40 ng/ml) significantly promoted the migration and invasion of DU145 and PC3 cells. Scale bars represent 200 mum for wound healing assay images and 50 mum for transwell assay images. d Western blotting assay revealed that CCL5 (5-40 ng/ml) could promote EMT and metastasis of both DU145 and PC3 cells. e CCL5 treatment (20-40 ng/ml) significantly increased not only the number but also the size of mammospheres formed by prostate cancer cells. Scale bar, 100 mum. f , g CCL5 treatment (20-40 ng/ml) significantly elevated the CD44 + /CD133 + subpopulation and the ALDH + subpopulation in DU145 and PC3 cells, indicating that CCL5 could promote the self-renewal of PCSCs. All values are presented as the mean +- SD. n \u003d 3, * p \u003c 0.05, ** p \u003c 0.01.','shortDescription':'Fig. 2 CCL5 promotes the invasion and the PCSCs subpopulation of prostate cancer cells in vitro. a , b CCL5 (2.5-40 ng/ml) had no obvious influences on the proliferation and colony formation capacities of the prostate cancer cell lines DU145 and PC3. c CCL5 addition (20-40 ng/ml) significantly promoted the migration and invasion of DU145 and PC3 cells. Scale bars represent 200 mum for wound healing assay im... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Apr 16, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12842_41419_2020_2435_Fig2_HTML.jpg','benchSciPubmedId':'32300100'},{'sku':'17-0441-82','imageId':'930780','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19108_MMR-21-05-2085-g00.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19108_MMR-21-05-2085-g00.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19108_MMR-21-05-2085-g00.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19108_MMR-21-05-2085-g00.jpg?time\u003d20240507','sortOrder':'82','description':'Figure 1. Identification and characteristics of hPDLSCs. Morphological characterization of hPDLSCs in (A) primary culture and (B) culture at passage 3. A periodontal membrane fragment is present and shown in A. Flow cytometry analysis of surface markers expressed on hPDLSCs, showing that they were positive for (D) 0CD44, (F) CD90 and (G) CD105, and negative for (C) CD34 and (E) CD45. (H) Following 3 weeks of culture in osteogenic induction medium, the cells were stained with alizarin red. Mineralized nodules are shown. (I) Following 3 weeks of culture in adipogenic induction medium, the cells were stained with Oil Red O. Lipid globules are shown (black arrow). hPDLSCs, human periodontal ligament stem cells; PE, phycoerythrin.','shortDescription':'Figure 1. Identification and characteristics of hPDLSCs. Morphological characterization of hPDLSCs in (A) primary culture and (B) culture at passage 3. A periodontal membrane fragment is present and shown in A. Flow cytometry analysis of surface markers expressed on hPDLSCs, showing that they were positive for (D) 0CD44, (F) CD90 and (G) CD105, and negative for (C) CD34 and (E) CD45. (H) Following 3 weeks o... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'May 1, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular medicine reports','journalText':'Molecular medicine reports 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19108_MMR-21-05-2085-g00.jpg','benchSciPubmedId':'32186753'},{'sku':'17-0441-82','imageId':'736878','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_7826_ijms-21-00404-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_7826_ijms-21-00404-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_7826_ijms-21-00404-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_7826_ijms-21-00404-g001.jpg?time\u003d20240507','sortOrder':'83','description':'Figure 1 Characterization of BCSC5 in vitro and in vivo. ( A ) Representative pictures of BCSC5 cultured in 3D and 2D conditions, scale bar 100 mum. ( B ) Sphere-forming capacity of BCSC5 cells in an anchorage-independent growth assay ( n \u003d 3). Data represent means + SEM. ( C , D ) Expression patterns of CD24 and CD44 ( C ) as well as EpCAM and CD49f ( D ) in BCSC5 cells analyzed by flow cytometry. ( E ) Tumor formation in limiting dilution xenografts of BCSC5. ( F ) Representative growth curves for limiting dilution assay of BCSC5 xenografts in immunocompromised NOD/SCID mice. ( G ) Immunohistochemical (IHC) analysis of ER, PR, and HER2 on sections of the BCSC5 xenograft tumors, scale bar 100 mum.','shortDescription':'Figure 1 Characterization of BCSC5 in vitro and in vivo. ( A ) Representative pictures of BCSC5 cultured in 3D and 2D conditions, scale bar 100 mum. ( B ) Sphere-forming capacity of BCSC5 cells in an anchorage-independent growth assay ( n \u003d 3). Data represent means + SEM. ( C , D ) Expression patterns of CD24 and CD44 ( C ) as well as EpCAM and CD49f ( D ) in BCSC5 cells analyzed by flow cytometry. ( E ) T... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jan 8, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of molecular sciences','journalText':'International journal of molecular sciences 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_7826_ijms-21-00404-g001.jpg','benchSciPubmedId':'31936348'},{'sku':'17-0441-82','imageId':'736877','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_7523_SCI2019-8035076.001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_7523_SCI2019-8035076.001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_7523_SCI2019-8035076.001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_7523_SCI2019-8035076.001.jpg?time\u003d20240507','sortOrder':'84','description':'Figure 1 Growth characteristics of USCs. (a) The morphology of USCs by passage and differentiation. Single, small, compact rice grain-like cells were observed on the third day after initial seeding, and they formed a colony on the seventh day. The cells were considered to be at P0 when the confluence reached 70-80% and were passaged to the next generation. The USCs maintained the rice grain-like morphology after several passages, and USCs from the P3 generation were induced to differentiate into SMCs and UCs. The cells showed an elongated and spindle-shaped morphology after SMC differentiation and a cobblestone-shaped morphology after UC differentiation. Scale bar: 50 mu m, 100 mu m, and 200 mu m. (b) The growth curve of USCs from the P3 generation. (c) Detection of surface markers in USCs using flow cytometry. USCs did not express hematopoietic stem cell markers (CD31: 0.45%, CD34: 0.28%) but expressed MSC markers (CD44: 100%, CD73: 97.1%, and CD105: 96.3%) and pericyte markers (CD146: 95.7%). (d) Detection of surface markers in USCs using IF. USCs did not express hematopoietic stem cell markers (CD31, CD34, and CD45) but did express MSC markers (CD44 and CD133), the ESC marker SSEA4, and pericyte markers (CD146, PDGFRB, and NG2). NC: negative control; PDGFRB: platelet-derived growth factor beta-receptor; NG2: neural/glial antigen 2. Scale bar: 25 mu m.','shortDescription':'Figure 1 Growth characteristics of USCs. (a) The morphology of USCs by passage and differentiation. Single, small, compact rice grain-like cells were observed on the third day after initial seeding, and they formed a colony on the seventh day. The cells were considered to be at P0 when the confluence reached 70-80% and were passaged to the next generation. The USCs maintained the rice grain-like morpholog... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'May 13, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Stem cells international','journalText':'Stem cells international 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_7523_SCI2019-8035076.001.jpg','benchSciPubmedId':'31885626'},{'sku':'17-0441-82','imageId':'930738','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15108_cancers-12-00029-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15108_cancers-12-00029-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15108_cancers-12-00029-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15108_cancers-12-00029-g001.jpg?time\u003d20240507','sortOrder':'85','description':'Figure 1 Identification of ADSCs. ( A ) ADSCs were isolated from the adipose tissue of breast tumors. After two to three passages, the expressions of ADSCs markers (CD90FITC, CD105PE, and CD44FITC) and the lack of CD34PE and CD45FITC were confirmed by flow cytometry. ( B ) The differentiation ability of ADSCs was tested by adipogenesis, osteogenesis, and chondrogenesis.','shortDescription':'Figure 1 Identification of ADSCs. ( A ) ADSCs were isolated from the adipose tissue of breast tumors. After two to three passages, the expressions of ADSCs markers (CD90FITC, CD105PE, and CD44FITC) and the lack of CD34PE and CD45FITC were confirmed by flow cytometry. ( B ) The differentiation ability of ADSCs was tested by adipogenesis, osteogenesis, and chondrogenesis.','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 20, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cancers','journalText':'Cancers 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15108_cancers-12-00029-g001.jpg','benchSciPubmedId':'31861872'},{'sku':'17-0441-82','imageId':'850432','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0008.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0008.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8294_nihms-1545180-f0008.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8294_nihms-1545180-f0008.jpg?time\u003d20240507','sortOrder':'86','description':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','shortDescription':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 11, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell host \u0026 microbe','journalText':'Cell host \u0026 microbe 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8294_nihms-1545180-f0008.jpg','benchSciPubmedId':'31784259'},{'sku':'17-0441-82','imageId':'850428','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0007.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0007.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8294_nihms-1545180-f0007.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8294_nihms-1545180-f0007.jpg?time\u003d20240507','sortOrder':'87','description':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','shortDescription':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 11, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell host \u0026 microbe','journalText':'Cell host \u0026 microbe 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8294_nihms-1545180-f0007.jpg','benchSciPubmedId':'31784259'},{'sku':'17-0441-82','imageId':'850421','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8294_nihms-1545180-f0005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8294_nihms-1545180-f0005.jpg?time\u003d20240507','sortOrder':'88','description':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','shortDescription':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 11, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell host \u0026 microbe','journalText':'Cell host \u0026 microbe 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8294_nihms-1545180-f0005.jpg','benchSciPubmedId':'31784259'},{'sku':'17-0441-82','imageId':'850416','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8294_nihms-1545180-f0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8294_nihms-1545180-f0003.jpg?time\u003d20240507','sortOrder':'89','description':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','shortDescription':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 11, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell host \u0026 microbe','journalText':'Cell host \u0026 microbe 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8294_nihms-1545180-f0003.jpg','benchSciPubmedId':'31784259'},{'sku':'17-0441-82','imageId':'850413','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8294_nihms-1545180-f0002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8294_nihms-1545180-f0002.jpg?time\u003d20240507','sortOrder':'90','description':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','shortDescription':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 11, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell host \u0026 microbe','journalText':'Cell host \u0026 microbe 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8294_nihms-1545180-f0002.jpg','benchSciPubmedId':'31784259'},{'sku':'17-0441-82','imageId':'726567','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_6043_1951f01.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_6043_1951f01.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_6043_1951f01.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_6043_1951f01.jpg?time\u003d20240507','sortOrder':'91','description':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','shortDescription':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Genome research','journalText':'Genome research 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_6043_1951f01.jpg','benchSciPubmedId':'31694869'},{'sku':'17-0441-82','imageId':'930758','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19113_gr6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19113_gr6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19113_gr6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19113_gr6.jpg?time\u003d20240507','sortOrder':'92','description':'Fig. 6 PSMD14 depletion reduces BMP6-mediated colorectal cancer stemness. (a, b) FACS analysis of CD133 + /CD44 + cells in PSMD14 - or ALK2 -depleted HCT116 cells, which were treated with 100 ng/ml BMP6 for 48 h. The proportion of the CD133 + /CD44 + fraction was described with the density plots (a) and a bar graph (b) . shGFP-expressing HCT116 cells were used as a control. (c) Sphere forming assay of PSMD14 - or ALK2 - depleted HCT116 cells. Spheres with a diameter above 50 mum were counted and described in a bar graph. Scale bars, 50 mum. (d) PSMD14 - or ALK2 -depleted HCT116 cells were treated with BMP6. Expression of pluripotent transcription factors were analyzed by immunoblotting with the indicated antibodies. siCON-expressing HCT116 cells were used as a control. (e, h) 2 x 10 4 cells of PSMD14 -, ALK2 -, ABCA7 - or ABCC4 -depleted HCT116 were respectively treated with 20 muM oxaliplatin and 30 muM DAPT and their viabilities were measured at 6 h. shGFP-expressing HCT116 cells were used as a control. (f, g) PSMD14 - or ALK2 -depleted HCT116 cells were treated with BMP6 for 6 h. Expressions of ABCA7 and ABCC4 were measured by quantitative RT-PCR. The data were statistically analyzed by two-way ANOVA followed by Bonferroni\u0027s multiple comparison test ( n \u003d 3, *** P \u003c 0.001 compared to the indicated controls. ns; not significant). The bars represent the mean +- s .d. The images in this figure are representative of three independent experiments. In (b), (c), (e) and (h) were','shortDescription':'Fig. 6 PSMD14 depletion reduces BMP6-mediated colorectal cancer stemness. (a, b) FACS analysis of CD133 + /CD44 + cells in PSMD14 - or ALK2 -depleted HCT116 cells, which were treated with 100 ng/ml BMP6 for 48 h. The proportion of the CD133 + /CD44 + fraction was described with the density plots (a) and a bar graph (b) . shGFP-expressing HCT116 cells were used as a control. (c) Sphere forming assay of PSMD1... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Nov 1, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'EBioMedicine','journalText':'EBioMedicine 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19113_gr6.jpg','benchSciPubmedId':'31685442'},{'sku':'17-0441-82','imageId':'726484','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_5963_ppat.1007856.g009.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_5963_ppat.1007856.g009.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_5963_ppat.1007856.g009.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_5963_ppat.1007856.g009.jpg?time\u003d20240507','sortOrder':'93','description':'Fig 9 The infection with IIIDelta rop16 :: ROP16 III parasites restores type III-like CNS response with higher CNS macrophages/microglia and T cells. Mice were inoculated with type III, IIIDelta rop16 , or IIIDelta rop16 : ROP16 parasites. Brains were harvested at 21 dpi and analyzed as in Figs 1(A), 1(B) , 2(C), 2(D) or 3(E) and 3(F) . A. Quantification of the number of Iba-1 + cells (macrophages/microglia). B. Quantification of the number of CD3 + T cells. Bars, mean +- SEM. N \u003d 12 fields of view/section, 3 sections/mouse, 4-5 mice/infected group. For each mouse, the number of cells/section was averaged to create a single point. C. Quantification of CNS Toxoplasma burden by qPCR for the Toxoplasma -specific B1 gene. D. Quantification of Toxoplasma cyst burden in brain sections stained with DBA. E. CNS mononuclear cells evaluated for the presence of M2 macrophages. F. CNS mononuclear cells evaluated for the presence of M1-like macrophages. Bars, mean +- SEM. N \u003d 12 fields of view/section, 3 sections/mouse, 4-5 mice/infected group. *p\u003c0.05, **p\u003c0.01, two-way ANOVA with Fisher\u0027s protected LSD. Data representative of 2 independent experiments using a single IIIDelta rop16 clone and IIIDelta rop16 : ROP16 clone.','shortDescription':'Fig 9 The infection with IIIDelta rop16 :: ROP16 III parasites restores type III-like CNS response with higher CNS macrophages/microglia and T cells. Mice were inoculated with type III, IIIDelta rop16 , or IIIDelta rop16 : ROP16 parasites. Brains were harvested at 21 dpi and analyzed as in Figs 1(A), 1(B) , 2(C), 2(D) or 3(E) and 3(F) . A. Quantification of the number of Iba-1 + cells (macrophages/microglia... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 1, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PLoS pathogens','journalText':'PLoS pathogens 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_5963_ppat.1007856.g009.jpg','benchSciPubmedId':'31648279'},{'sku':'17-0441-82','imageId':'726524','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_6036_IJO-55-06-1296-g00.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_6036_IJO-55-06-1296-g00.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_6036_IJO-55-06-1296-g00.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_6036_IJO-55-06-1296-g00.jpg?time\u003d20240507','sortOrder':'94','description':'Figure 1 Proportion of CD44 + /CD133 + cancer stem cells in ovarian cancer tissues of each patient by flow cytometry.','shortDescription':'Figure 1 Proportion of CD44 + /CD133 + cancer stem cells in ovarian cancer tissues of each patient by flow cytometry.','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'International journal of oncology','journalText':'International journal of oncology 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_6036_IJO-55-06-1296-g00.jpg','benchSciPubmedId':'31638182'},{'sku':'17-0441-82','imageId':'855178','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9897_nihms-1549105-f0004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9897_nihms-1549105-f0004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9897_nihms-1549105-f0004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9897_nihms-1549105-f0004.jpg?time\u003d20240507','sortOrder':'95','description':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','shortDescription':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 6, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Circulation research','journalText':'Circulation research 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9897_nihms-1549105-f0004.jpg','benchSciPubmedId':'31630621'},{'sku':'17-0441-82','imageId':'855157','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9897_nihms-1549105-f0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9897_nihms-1549105-f0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9897_nihms-1549105-f0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9897_nihms-1549105-f0003.jpg?time\u003d20240507','sortOrder':'96','description':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','shortDescription':'Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Dec 6, 2019, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Circulation research','journalText':'Circulation research 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9897_nihms-1549105-f0003.jpg','benchSciPubmedId':'31630621'},{'sku':'17-0441-82','imageId':'843162','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12841_MOL2-14-139-g003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12841_MOL2-14-139-g003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12841_MOL2-14-139-g003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12841_MOL2-14-139-g003.jpg?time\u003d20240507','sortOrder':'97','description':'Figure 3 Knocking down of PIK3CA failed to reverse EMT and reduce CSC population. (A) Western blotting of p110alpha, E-cadherin and vimentin in CU110-2 cells stably transfected with lentiviral-mediated shRNA ( shPIK3CA ) or a scrambled control ( SCR ). GAPDH was used as a loading control. Quantitation of western blots is shown in right. (B) HNSCC Sphe-forming assay of CU110 cells stably transfected either shPIK3CA or SCR lentivirus. Sphes with diameter \u003e\u003d 30 mum were counted; quantification of Sphe is shown on the right, n \u003d 3; error bars indicate SD. * P \u003c 0.05 (two-tailed Student t- test). Scale bar: 100 u m . (C) FACS analysis of CD44 in CU110 cells stably transfected either shPIK3CA or SCR lentivirus. Quantification of CD44 population is shown on top. n \u003d 3; error bars indicate SD. (D) FACS analysis of CD24 in CU110 cells stably transfected either shPIK3CA or SCR lentivirus. Quantification of CD24 population is shown on top. n \u003d 3; error bars indicate SD. (E) SP fraction using Hoechst dye-effluxing analysis in CU110 cells stably transfected either shPIK3CA or SCR lentivirus. Quantification of SP fraction is shown on top. n \u003d 3; error bars indicate SD. * P \u003c 0.05 (two-tailed Student t- test). (F) HNSCC Sphe-forming assay of Fadu or UMSCC47 cell lines stably transfected with either shPIK3CA or SCR . The quantification is shown on the left. Error bars indicate SD. Scale bar: 100 u m.','shortDescription':'Figure 3 Knocking down of PIK3CA failed to reverse EMT and reduce CSC population. (A) Western blotting of p110alpha, E-cadherin and vimentin in CU110-2 cells stably transfected with lentiviral-mediated shRNA ( shPIK3CA ) or a scrambled control ( SCR ). GAPDH was used as a loading control. Quantitation of western blots is shown in right. (B) HNSCC Sphe-forming assay of CU110 cells stably transfected either s... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jan 1, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular oncology','journalText':'Molecular oncology 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12841_MOL2-14-139-g003.jpg','benchSciPubmedId':'31600013'},{'sku':'17-0441-82','imageId':'843183','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12841_MOL2-14-139-g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12841_MOL2-14-139-g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12841_MOL2-14-139-g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12841_MOL2-14-139-g006.jpg?time\u003d20240507','sortOrder':'98','description':'Figure 6 Targeting multiple RTK pathways effectively eliminates CSC populations with inhibiting Ephs, TRKs, and c-Kit the most prominent. (A) FACS analysis of CD44 (left) or ALDH (right) in CU110 cells treated with LDN211904. Error bars indicate SD. n \u003d 3. * P \u003c 0.05 (two-tailed Student t- test). (B) FACS analysis of ALDH in CU110 cells treated with GNF5837. Error bars indicate SD. n \u003d 3. * P \u003c 0.05 (two-tailed Student t- test). (C) FACS analysis of CD44 (left) or SP fraction (right) in CU110 cells treated with imatinib. Error bars indicate SD. n \u003d 3. * P \u003c 0.05 (two-tailed Student t- test). (D) Effect of pharmaceutical inhibitors (as indicated in the figure) on reducing CSC population in human HNSCC cell lines: Fadu and UMSCC47, using Sphe-forming assay. The quantification is shown on right. n \u003d 3; error bars indicate SD. * P \u003c 0.05 (two-tailed Student t- test). Scale bar: 100 u m.','shortDescription':'Figure 6 Targeting multiple RTK pathways effectively eliminates CSC populations with inhibiting Ephs, TRKs, and c-Kit the most prominent. (A) FACS analysis of CD44 (left) or ALDH (right) in CU110 cells treated with LDN211904. Error bars indicate SD. n \u003d 3. * P \u003c 0.05 (two-tailed Student t- test). (B) FACS analysis of ALDH in CU110 cells treated with GNF5837. Error bars indicate SD. n \u003d 3. * P \u003c 0.05 (two-ta... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Jan 1, 2020, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular oncology','journalText':'Molecular oncology 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12841_MOL2-14-139-g006.jpg','benchSciPubmedId':'31600013'},{'sku':'17-0441-82','imageId':'726457','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_5950_MMR-20-04-3123-g00.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_5950_MMR-20-04-3123-g00.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_5950_MMR-20-04-3123-g00.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_5950_MMR-20-04-3123-g00.jpg?time\u003d20240507','sortOrder':'99','description':'Figure 1. Characterization of PDLSCs. (A) PDL cell clusters exhibited radiating or whirlpool-like morphology. The central structure in this image is a fragment of PDL tissue. Scale bar, 200 mum (B) CD146 + PDLSCs were small, round, fusiform and triangular. Scale bar, 100 mum. (C) PDLSCs were positive for the stem cell markers CD44, CD90 and CD105, but negative for CD34 and CD45, as detected by flow cytometry. PDL, periodontal ligament; PDLSCs, PDL stem cells.','shortDescription':'Figure 1. Characterization of PDLSCs. (A) PDL cell clusters exhibited radiating or whirlpool-like morphology. The central structure in this image is a fragment of PDL tissue. Scale bar, 200 mum (B) CD146 + PDLSCs were small, round, fusiform and triangular. Scale bar, 100 mum. (C) PDLSCs were positive for the stem cell markers CD44, CD90 and CD105, but negative for CD34 and CD45, as detected by flow cytometr... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD44 Antibody in Flow Cytometry (Flow)','title':'CD44 Antibody (17-0441-82) in Flow','appAbv':'Flow','dateTime':'Oct 1, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular medicine reports','journalText':'Molecular medicine reports 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_5950_MMR-20-04-3123-g00.jpg','benchSciPubmedId':'31432132'}],'Advanced Verification':[]}" image-displayed-id="'121365'" product-sub-type="'antibody_primary'" prod-type="'antibody'" page-type="PDP" product-id="'17-0441-82'"> <div class="tabs"> <ul class="nav nav-pills"> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Antibody Testing Data"> <a class="tab-text"> Antibody Testing 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y="0px" viewBox="0 0 22 22" style="enable-background:new 0 0 22 22;" xml:space="preserve"> <style type="text/css"> .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#222222;} </style> <title>Group 53</title> <desc>Created with Sketch.</desc> <g id="Symbols"> <g id="rollover-expand-icon" transform="translate(-8.000000, -8.000000)"> <g id="Group-48"> <g id="Group-53" transform="translate(8.000000, 8.000000)"> <g id="Group-49" transform="translate(0.000000, 0.000000)"> <g id="Group-54"> <g id="Group-55" transform="translate(0.000000, -0.000000)"> <path id="Fill-1" class="st0" d="M21.9,14.6h-2.2c0,1,0,1.9,0,2.9c0,0.2,0,0.4,0,0.6c-0.1-0.1-0.2-0.2-0.3-0.2 c-1.3-1.3-2.7-2.7-4-4l-1.6,1.5c1.3,1.4,2.7,2.7,4,4.1c0.1,0.1,0.1,0.2,0.3,0.3c-0.2,0-0.3,0-0.4,0c-1,0-2.1,0-3.1,0V22 c2.3,0,4.8,0,7.1,0.1c0.1,0,0.2,0,0.3,0c0-0.5-0.1-0.9-0.1-1.3C21.9,18.7,21.9,16.6,21.9,14.6z"/> <path id="Fill-4" class="st0" d="M1.3,21.9c1.9,0,4,0,6,0v-2.2c-1,0-1.9,0-2.9,0c-0.2,0-0.4,0-0.6,0C3.9,19.6,4,19.5,4,19.4 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<div class = "verification-certificate hide" > <span class="icon-certification"></span> <span class="adv-cert-text">{{ $ctrl.currentElement.advancedVerification.fullName }}</span> <div class="cert-provider">{{ $ctrl.currentElement.advancedVerification.text }}</div> </div> <h2 class="product-name" ng-show="!$ctrl.isVideo"> CD44 Antibody (17-0441-82) in Flow </h2> <div ng-show="!$ctrl.isVideo"> <div class="image-desc"> <div class="product-desc-text viewing-more-long-description"> <span class="image-journal-text" > </span> <span class="short-desc"> Staining of C57BL/6 splenocytes with staining buffer (autofluorescence) (open histogram) or 0.03 µg of Anti-Human/Mouse CD44 APC (filled histogram). Total viable cells were used for analysis. </span> <span class="verification-info hide" ng-if="$ctrl.hasVerificationMethod"> <a rel="nofollow" ng-href="{{$ctrl.currentElement.advancedVerification.uri}}" >{{ $ctrl.currentElement.advancedVerification.fullName }} validation info.</a> </span> <a href="#" class="images-view-more-text hide" ng-if="$ctrl.showViewMore" onclick="window.THERMO_FISHER.inp.openImageGalleryModal(event, this)"> View more </a> </div> </div> <div class="img-desc-footer"> <div class="benchsci-pubmed-footer"> <div ng-cloak ng-if="$ctrl.currentElement.benchsci || $ctrl.sourceType === '3'" class="images-benchsci-footer"> <div class="images-benchsci-link" tabindex="0"> <span>Published figure supplied by</span> <span class="icon-benchsci-logo"> <svg id="Layer_1" data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 89.75 23.21"><defs><style>.cls-1{fill:#222222;}</style></defs><title>benchsci-logo</title><g id="logo-blue-copy-3"><g id="logo-blue-copy-2"><path id="path14" class="cls-1" d="M34.54,11.49a2.45,2.45,0,0,0,1.59-2.34c0-1.69-1.21-2.94-3.32-2.94H28.88v10.9h4.21a3.06,3.06,0,0,0,3.37-3A2.57,2.57,0,0,0,34.54,11.49ZM31,8h1.49c1,0,1.57.53,1.57,1.36a1.36,1.36,0,0,1-1.55,1.37H31Zm1.72,7.35H31V12.47h1.75a1.42,1.42,0,0,1,1.62,1.46C34.34,14.79,33.72,15.34,32.69,15.34Z"/><path id="path16" class="cls-1" d="M41.34,9.32a3.8,3.8,0,0,0-3.72,4,3.83,3.83,0,0,0,3.91,4.05A3.39,3.39,0,0,0,45,15l-1.71-.51a1.67,1.67,0,0,1-1.72,1.15,1.85,1.85,0,0,1-1.91-1.73H45s0-.34,0-.63C45.09,10.81,43.69,9.32,41.34,9.32Zm-1.66,3.15A1.63,1.63,0,0,1,41.37,11a1.52,1.52,0,0,1,1.69,1.49Z"/><path id="path18" class="cls-1" d="M50.58,9.35a2.48,2.48,0,0,0-2.18,1.14v-1h-2v7.57h2.05V12.75a1.42,1.42,0,0,1,1.41-1.57,1.34,1.34,0,0,1,1.4,1.52v4.42h2V12.35C53.32,10.68,52.46,9.35,50.58,9.35Z"/><path id="path20" class="cls-1" d="M58.2,15.47a1.94,1.94,0,0,1-1.94-2.14,1.92,1.92,0,0,1,1.91-2.12,1.64,1.64,0,0,1,1.67,1.27l1.83-.61a3.45,3.45,0,0,0-3.55-2.55,3.83,3.83,0,0,0-2.82,1.16,3.88,3.88,0,0,0-1.1,2.85,3.9,3.9,0,0,0,4,4,3.5,3.5,0,0,0,3.53-2.55l-1.8-.6A1.72,1.72,0,0,1,58.2,15.47Z"/><path id="path22" class="cls-1" d="M67,9.35a2.72,2.72,0,0,0-2.07.83V6h-2V17.12h2V12.67a1.43,1.43,0,0,1,1.42-1.48,1.34,1.34,0,0,1,1.4,1.53v4.41h2V12.35A2.67,2.67,0,0,0,67,9.35Z"/><path id="path24" class="cls-1" d="M75.82,11.05l-1.63-.35a1.58,1.58,0,0,1-1.4-1.59A1.93,1.93,0,0,1,74.9,7.3a2.21,2.21,0,0,1,2.3,1.86l1.36-.48a3.73,3.73,0,0,0-7.29.54,3,3,0,0,0,2.67,3l1.55.33c1.09.24,1.63.91,1.63,1.7,0,.95-.74,1.74-2.25,1.74a2.51,2.51,0,0,1-1.79-.63,2.45,2.45,0,0,1-.82-1.71l-1.45.46a3.79,3.79,0,0,0,4.08,3.24c2.32,0,3.76-1.52,3.76-3.22C78.65,12.59,77.63,11.45,75.82,11.05Z"/><path id="path26" class="cls-1" d="M83.25,16A2.33,2.33,0,0,1,81,13.41a2.31,2.31,0,0,1,2.24-2.59,1.93,1.93,0,0,1,2,1.57l1.31-.55a3.22,3.22,0,0,0-3.29-2.35,3.7,3.7,0,0,0-3.72,3.92,3.75,3.75,0,0,0,3.74,3.94A3.41,3.41,0,0,0,86.59,15l-1.28-.55A2,2,0,0,1,83.25,16Z"/><path id="path28" class="cls-1" d="M88.69,5.89a1,1,0,1,0,.75.29A1,1,0,0,0,88.69,5.89Z"/><polygon id="rect30" class="cls-1" points="87.99 9.72 89.42 9.72 89.42 17.11 87.99 17.11 87.99 9.72"/><path id="path32" class="cls-1" d="M14.58,8.87A4.1,4.1,0,0,0,15.8,6H14.31a2.62,2.62,0,0,1-.76,1.87L11.66,9.7l-2-2A2.61,2.61,0,0,1,9,6H7.53A4.09,4.09,0,0,0,8.74,8.87l1.87,1.87L8.74,12.61a4.08,4.08,0,0,0-1.21,2.92v2.29H9.18V16.73h1.66v1.09h1.64V16.73h1.65v1.09H15.8V15.53a4.11,4.11,0,0,0-1.21-2.92l-1.38-1.36-1,1.05,1.37,1.36a2.63,2.63,0,0,1,.77,1.58H9a2.68,2.68,0,0,1,.76-1.58Z"/><path id="path34" class="cls-1" d="M11.61,23.21a11.61,11.61,0,1,1,11.6-11.6A11.6,11.6,0,0,1,11.61,23.21Zm0-21.89A10.29,10.29,0,1,0,21.9,11.61,10.28,10.28,0,0,0,11.61,1.32Z"/></g></g></svg> </span> <span id="bechsci-tooltip-{{$ctrl.productId}}" class="bechsci-tooltip-icon" data-toggle="tooltip" ng-click="$ctrl.showBechSciTooltip()" close-tooltip="$ctrl.closeBechSciTooltip()" data-html="true" title="Clicking this link will redirect you to the <a href='https://www.benchsci.com/' target='_blank'> BenchSci</a> website that provides third-party scientific content. 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src="https://www.thermofisher.com/antibody/images/150/tfs_5963_ppat.1007856.g009.jpg?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="726524" data-index="93"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_6036_IJO-55-06-1296-g00.jpg?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="855178" data-index="94"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9897_nihms-1549105-f0004.jpg?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="855157" data-index="95"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_9897_nihms-1549105-f0003.jpg?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="843162" data-index="96"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_12841_MOL2-14-139-g003.jpg?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="843183" data-index="97"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_12841_MOL2-14-139-g006.jpg?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="726457" data-index="98"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_5950_MMR-20-04-3123-g00.jpg?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)"/> </div> </div> </div> </div> </div> <noscript> <div itemscope itemtype="http://schema.org/ImageGallery"> <h2>Product Image Gallery</h2> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/17-0441-82-CD44-Flow-20170216130641.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Staining of C57BL/6 splenocytes with staining buffer (autofluorescence) (open histogram) or 0.03 µg of Anti-Human/Mouse CD44 APC (filled histogram). Total viable cells were used for analysis.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15033_13058_2018_944_Fig5_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">The cancer stem cell (CSC)-like characteristics of tumor cells isolated from the secondary enhanced green fluorescent protein (EGFP) + MCF7/HRE-EGFP xenografts. a Generation of secondary MCF7/HRE-EGFP xenografts by re-implantation of sorted EGFP + and EGFP - cells isolated from the primary MCF7/HRE-EGFP xenografts. Tumor cells freshly isolated from the secondary xenografts were sorted into EGFP + and EGFP - populations for ( b ) fluorescence-activated cell sorting (FACS) analysis of the CD44 + /CD24 + and CD44 + populations ( n = 5 for EGFP + cells, n = 4 for EGFP - cells; *** p < 0.001, Student's t test). c Side population (SP) of the secondary xenograft-derived tumor cells. MCF7 tumor cells were isolated from the secondary xenografts derived from EGFP + and EGFP - tumor cells, respectively, and expanded in vitro for three passages. Cells were stained with Hoechst 33342 for side population analysis by FACS. Verapamil (50 muM) was used to block nuclear export of Hoechst 33342. These results were validated in two independent experiments. d Clonogenic potential of the freshly sorted EGFP + and EGFP - populations from the secondary xenografts ( n = 6; **** p < 0.0001, *** p < 0.001, Student's t test)</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29140_13287_2023_3411_MOESM2_ESM.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Additional file 2: Figure S1. Characterization of ACSCs. a After 7 days of culturing, fibroblast-like cells migrate out from cartilage chips. b The result of ACSCs morphology at passage 4 and passage 8. c Flow cytometry staining demonstrated that negative express the hematopoietic and endothelial markers (CD45, CD31 and CD235A), and were positive for MSC markers (such as CD29, CD44, CD90, CD105 and PDPN) (Fig. S1c). The Scale bars represent 200mum (Fig. S1a, S1b), respectively. Experiments were repeated independently for more than three times. All data are shown as the mean +- S.D.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29067_41586_2023_6436_Fig10_ESM.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Extended Data Fig. 5 Validation of PF4-mediated changes to spleen-derived immune cells in aged mice. (a-c) Flow cytometry gating strategy for the identification of CD45+ myeloid (lin-) and lymphoid (lin+) cells, neutrophils (CD45+, lin-, Ly6G+), and macrophages (CD45+, lin-, F4/80+, CD11b+) in the aged spleen. (b) Comparison of the ratio of myeloid cells to lymphoid cells in the spleen of saline and PF4 treated aged mice (n = 8 saline; 9 PF4 mice). (c) Comparison of the relative populations of neutrophils and macrophages in the spleen (n = 8 saline; 9 PF4 mice). (d) qPCR of inflammation-related genes relative to Gapdh in the aged spleen (n = 12 saline; 11 PF4 mice). (e-f) Flow cytometry gating strategy for the identification of CD4+ T cells, CD8+ T cells, and CD8+ T effector memory cells (CD45+, CD3+, CD8+, CD44 HI , CD62L LO) in the aged spleen. (f) Comparison of the relative populations of T cells in the spleen (n = 8 mice/group). (g) Schematic of aged T cell isolation, activation, and treatment with vehicle or PF4 (1 mug mL -1). (h,i) Flow cytometry gating strategy for the identification of the exhaustion marker PD1 in CD4+ and CD8+ T cells following in vitro activation of aged T cells. (i) Quantification of PD-1 expression in CD4+ and CD8+ T cells by flow cytometry (n = 6 biologically independent samples/group). Data shown as mean +- s.e.m. ; two-tailed unpaired t -test (b,c,d,f), two-way ANOVA with a Sidak post hoc test (i). Source data</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29159_nihms-1898012-f0005.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 4. QFL T cells upregulate effector markers CD44 and KLRG1 in MCMV-infected mice (A and B) WT mice were uninfected, ERAAP KO immunized, or MCMV infected (1e6 PFU). QFL T cells were enriched from the spleen of each mouse, and CD44 and KLRG1 expression was analyzed. (A) Representative flow cytometry plots for CD44 expression in QFL T cells. (B) Compiled data of percentage of CD44 + QFL T cells for each group. Data are shown as mean +- SEM. (C) Representative flow cytometry plots for KLRG1 expression in QFL T cells. (D) Compiled data of percentage of KLRG1 + QFL T cells for each group. Data from (B) and (C) were pooled over two independent experiments, with 1-3 samples for each condition per experiment, and are shown as mean +- SEM. Comparisons between groups were made using an ordinary one-way ANOVA multiple comparisons test, *p < 0.0332, **p < 0.0021, ***p < 0.0002, ****p < 0.0001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29154_NRR-18-1841-g004.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Identification of ADSCs. (A) ADSCs exhibited characteristic spindle-like morphology, as indicated by red arrows. The mesenchymal markers CD34 (B), CD44 (C), CD90 (D), CD105 (E) and the negative control marker HLA-DR (F) were used to analyze the cells by flow cytometry. The indicated markers are presented as solid red peaks, and the isotype controls are presented as solid blue peaks. The experiment was independently repeated three times. ADSCs: Adipose-derived stem cells.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24774_cancers-14-06218-g003a.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Knockdown of circ_RNF13 inhibits stemness and increases chemosensitivity in CRC cells. ( A ) The circ_RNF13 level in CRC cells was detected by qRT-PCR. ( B ) The protein level of DDX27 was detected by Western blot analysis. ( C ) The sphere-forming abilities of CRC cells were monitored by sphere formation assay. ( D ) The cell population of CD44 + CD133 + cells was detected by flow cytometry. ( E ) The CD44 or CD133 level in CRC cells was detected by IF staining. Red, CD44; green, CD133; blue, DAPI. Scale bar, 25 um. ( F ) The protein levels of stemness markers (CD44, CD133, SOX2, OCT4, and NANOG) were detected by Western blot analysis. ( G ) Cell viability was monitored by CCK-8 assay. ( H ) The colony-forming abilities of CRC cells were assessed by colony formation assay. ( I ) Cell apoptosis was measured by Annexin V-FITC/PI staining. Each experiment was performed at least three times independently. *, p < 0.05, **, p < 0.01, ***, p < 0.001. Full pictures of the Western blots are presented in Figure S2 .</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24774_cancers-14-06218-g004a.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Knockdown of DDX27 inhibits stemness and increases chemosensitivity in CRC cells. ( A ) The protein level of DDX27 was detected by Western blot analysis. ( B ) The sphere-forming abilities of CRC cells were monitored by sphere formation assay. ( C ) The cell population of CD44 + CD133 + cells was detected by flow cytometry. ( D ) The CD44 or CD133 level in CRC cells was detected by IF staining. Red, CD44; green, CD133; blue, DAPI. Scale bar, 25 um. ( E ) The protein levels of stemness markers (CD44, CD133, SOX2, OCT4, NANOG) were detected by Western blot analysis. ( F ) Cell viability was monitored by CCK-8 assay. ( G ) The colony-forming abilities of CRC cells were assessed by colony formation assay. ( H ) Cell apoptosis was measured by Annexin V-FITC/PI staining. Each experiment was performed at least three times independently. *, p < 0.05, **, p < 0.01, ***, p < 0.001. Full pictures of the Western blots are presented in Figure S2 .</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24773_sciadv.abp8674-f3.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 3. SCLC ex vivo tumors have distinct phenotypic states regulated by the epigenome. ( A ) Whole transcriptome associations in matched CCX1 primary tumor, PDX, and ex vivo cells. ( B ) Scatter star plot of gene expression [transcript per million (TPM)] for program defining genes in five matched PDX and ex vivo cells: CCX1, CCX280, CBX41, CBX163, and CBX140. Hubs = means; spokes = individual sample values. ( C ) Phase contrast images (x20) of CCX1 ex vivo cells. Arrows mark representative populations of cells in each stratum. ( D ) Strata profiled by immunoblot. ( E ) Flow cytometry data show CD44- and EpCAM-expressing cells in each stratum. APC, allophycocyanin; PE, phycoerythrin. ( F ) Invasion assay of strata or cells sorted via fluorescence-activated cell sorting (FACS) for CD44 or EpCAM. Values are an average of the number of stained cells from four high-power fields. Error bars represent SEM of at least three different experiments. The student t test with Welch's correction was used for statistical analysis. * P < 0.05. ( G ) CCX1 ex vivo cells (5 x 10 6 ) were treated with chemotherapy (EP; etoposide (1.5 mug/ml) and cisplatin (0.5 mug/ml)] for 5 days, followed by drug washout or irradiated to a total dose of 10 Gy (2 Gy per fraction daily). CD44- and EpCAM-expressing cells were quantified by flow cytometry at the indicated times, and the change in the percentage of CD44 and EpCAM (%Delta) calculated relative to t = 0. ( H and I ) Cells with differential express</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24772_41541_2022_560_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 2 AMP-CpG immunization generates long-lived memory T cell responses that rapidly expand upon antigen re-exposure in mice. C57Bl/6 J mice ( n = 5) were immunized twice with 10 ug WH-01 RBD protein and 1 nmol soluble or AMP-CpG. a , b 17 weeks post dose 2, blood was collected for a pre-recall time point, followed by subcutaneous challenge with 10 ug WH-01 RBD protein on the next day, and a second blood collection 7 days later. a Pre-challenge peripheral blood leukocytes were stained for CD44 and CD62L. Shown are percentages of tetramer + CD44 + CD62L + cells among CD8 + T cells. b Peripheral blood CD8 + T cells collected before and after challenge were stained with tetramer specific for Spike RBD and analyzed by flow cytometry. c - g 30 weeks post dose 2, mice were challenged subcutaneously with 10 ug WH-01 RBD protein and assayed 7 days later. CD8 + T cells collected from blood ( c ) and perfused lung ( e ), and CD4 + T cells collected from blood ( d ) and perfused lung ( f ) were stimulated with WH-01 RBD OLPs and assayed for intracellular cytokines by flow cytometry. g Splenocytes were restimulated with WH-01 RBD OLPs and assayed for IFNgamma production by ELISpot. Mock vaccines contained AMP-CpG without the addition of antigen. Values depicted are means+-standard deviation. * p < 0.05, ** p < 0.01 , *** p < 0.001, **** p < 0.0001 by one-way ANOVA followed by Tukey's post-hoc analysis applied to tetramer + or cytokine + T cell frequencies, or SFC numbers ( a - g ).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24714_41598_2022_22955_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 2 ANRIL/miR-181b-5p/S1PR1 expression and T cell activation in myocardial tissues of UC mice ( A ) qRT-PCR of ANRIL expression; ( B ) qRT-PCR of miR-181b-5p expression; ( C ) qRT-PCR of S1PR1 mRNA expression; ( D ) Western blot of S1PR1 protein expression; ( E ) immunofluorescence of S1PR1 expression, scale bar = 50 mum; ( F ) flow cytometry of T cell markers (CD3, CD44, and Th17A); ( G ) quantifying of cells positive for CD3, CD44, and Th17A. *P < 0.05, **P < 0.01, ***P < 0.001 vs. control. Data was analyzed using one-way analysis of variance (ANOVA) followed by Tukey's test.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24714_41598_2022_22955_Fig6_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">The effects of ANRIL silencing or miR-181b-5p overexpression on pathological changes and T cell activation in UC mice ( A ) HE and Masson staining of myocardial and nephridial tissues, scale bar = 20 mum; ( B ) flow cytometry of T cell markers (CD3, CD44, and Th17A); ( C ) quantifying of cells positive for CD3, CD44, and Th17A. ***P < 0.001 vs. control; ## P < 0.01, ### P < 0.001 vs. model. Data was analyzed using t test or one-way analysis of variance (ANOVA) followed by Tukey's test.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24771_biomedicines-10-02488-g001a.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1 CD44 expression was higher in metastatic lymph nodes, and CD44 knockdown reduced the migration and invasion abilities of breast cancer cells: ( a ) Flow cytometric analysis of CD44 expression in primary breast tumors (T) and paired metastatic lymph nodes (LN) in 14 breast cancer patients' samples. ( b ) The expression of CD44 in breast cancer tissues, as determined by immunohistochemistry, was assessed by the H-score. The discriminatory threshold was set at H-score = 200, and existing samples were reread and classed as low (H-score < 200) or high (>=200) CD44 expression. (left) Bar figure showing the quantification results for CD44 expression in primary tumors (T) and lymph node metastases (LN) was assessed by immunohistochemistry in 35 breast cancer patients' samples. Scale bar = 100um. ( c ) Cell migration and invasion abilities in control and CD44 knockdown MDA-MB-231 and ZR75 cells (Luc: luciferase, KD: knockdown). ( d ) Cell migration and invasion abilities in control and CD44-overexpressing ZR75 and MCF7 cells (EV: empty vector, OE: overexpression). ( e ) Mammosphere formation ability of control, CD44 knockdown ZR75, and CD44 overexpressed ZR75 and MCF7 cells. The data are presented as mean +- SD. * Indicates p < 0.05, and ** indicates p < 0.01.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24769_gr7.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Immunological effect provoked by APTP NPs plus X-ray irradiation. '+' represents with X-ray irradiation, '-' represents without X-ray irradiation. a Schematic illustration of tumor therapeutic procedure in vivo. b,c Representative flow cytometry plots ( b ) and quantitative analysis c results of lymphatic derived DCs maturation (CD11c + CD80 + CD86 + , gated on CD11c + DCs) under different treatments. d,e Quantitative analysis of Ki67 + ( d ) and GzmB + ( e ) CD8 + T cells in lymph nodes after gating on CD3 + CD8 + T cells under different treatments. f-i CD8 + and CD4 + T cells after gating on CD45 + CD3 + T cells in primary and distant tumors. j,k Representative flow cytometry plots ( j ) and quantitative analysis ( k ) of effector memory T cells (CD3 + CD8 + CD44 + CD62L - , gated on CD3 + CD8 + T cells) in spleens under different treatments. l-o IFN-gamma, IL-6, IL-12p70, and TNF-alpha secretion in serum under different treatments. Data are presented as mean +- SD (n = 4). One-way ANOVA analysis with Tukey's multiple comparison test was used. Significance is presented as *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. Fig. 7</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24768_41419_2022_5262_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 1 RNF4 is essential for OD of hBMSCs. A Western blot analysis of endogenous RNF4 and beta-catenin levels in protein extracts derived from untreated hBMSCs (Un) or cells in which OD was induced (OI) for fourteen days; B Western blot analysis of endogenous RNF4 protein levels in protein extract derived from wild-type hBMSC or hBMSCs in which RNF4 was knocked down using shRNA (sh-RNF4#1) or control scrambled shRNA (sh-Scr) with or without OI for 14 days. Actin (A) and tubulin (B) serve as a loading control. C Accumulation of calcium precipitates during OD at day zero and 21 days of OI, as evident by Alizarin Red staining (AR, red) in control (sh-Scr) or hBMSCs in which RNF4 was knocked down using sh-RNA (sh-RNF4). Brilliant-Violate staining (BV, purple) marks viable cells. D Alkaline phosphate activity upon 7, 14 days of OI of control scrambled treated hBMSCs, or hBMSCs in which RNF4 was knocked down using shRNA ( n = 2 ** p < 0.01; ns non-significance). E qPCR analysis of RNF4 and RUNX2 mRNA levels in control (sh-SCR) or RNF4-targeted hBMSCs (sh-RNF4). F , G FACS-assisted analysis of OD of the indicated cell surface markers at day zero and 14 days of OD. In both F and G a representative FACS analysis is shown, and Bar-graph represents three independent biological experiments. CD44 and CD90 are markers of undifferentiated hBMSCs, n = 3 *** p < 0.001; ** p < 0.01.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24767_JEM_20211688_Fig6.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 6. Identifying lncEry -interacting proteins. (A) Experimental design for identifying lncEry -interacting proteins. In vitro-transcribed lncEry -3 was used as the bait, and anti- lncEry -3 was used as the control. (B and C) RNA pulldown and mass spectrometry analyses of lncEry -interacting proteins. Whole-cell extracts from MEP (B) or MEL (C) were prepared and subjected to RNA pulldown using in vitro-transcribed lncEry -3 or anti- lncEry -3 as the bait. After extensive washing, the bound proteins were eluted and visualized by silver staining on SDS-PAGE. The protein bands on the gel were recovered by trypsinization and analyzed by mass spectrometry. Detailed results from the mass spectrometric analysis are provided in Tables S4 and S5 . (D) Overlapping lncEry interaction partners from MEP and MEL cells, as analyzed by mass spectrometry. (E) RNA-pulldown-purified proteins retrieved using the indicated baits were analyzed by Western blotting with antibodies against the indicated proteins. (F and G) CFU colony assays of 2,000 cKit + cells transfected with control, Wdr82, or Ddx5 shRNAs cultured for 10-14 d in complete methylcellulose-based medium. The colony numbers are provided in G ( n = 3-4 wells). Representative images from triplicate experiments are shown in F. (H) Cellular extracts of cKit + cells transfected with control, Wdr82, or Ddx5 shRNAs were prepared and analyzed by Western blotting with indicated antibodies. (I) BFU-E colony assays of 2,000 cKit + cells tran</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20580_urn-x-wiley-20457634-media-cam44533-cam44533-fig-0005.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">5 FIGURE (A) FACS analysis for CD44 or Sca-1-positive subpopulations in primary #1 cells after Wnt small-molecule inhibitors for 24 h. CWP291, 1 uM CWP232291; BC21, 10 uM BC21; CCT, 20 uM CCT031374; PKF, 2 uM PKF 118-774; Cisplatin, 1 uM cisplatin. Right, representative FACS images showing reduced CD44 or Sca-1-positive cells in primary #1 cells after CWP232291 treatment. (B) Sphere-forming assay showing reduced tumorsphere formation from primary #1 cells after the treatment for 7 days with Wnt inhibitors. The spheres greater than 100 mm of diameter were enumerated. Right, representative images of tumor spheres after the treatment with Wnt inhibitors. (C) CWP232291 inhibited primary (with CWP232291) and second sphere formation (without CWP232291) in primary #1 and SW620. (D) Representative images of tumorspheres from primary #1 cells of (C). (E) Representative IF images for CD133, Lgr-5, and Sca-1, putative mouse intestinal cancer stem cell markers, in vehicle- or CWP232291-treated allografts of SCID mice. SCID mice injected with primary #1 cell were treated with 100 mg/kg CWP232291 twice a week for 8 weeks. Bottom, IF scoring for CD133, Lgr-5, and Sca-1-positive tumor cells in vehicle- ( n = 3) or CWP232291-treated ( n = 3) allografts. Bar = 100 um. (F) FACS analysis for CD133 in CWP232291- or vehicle-treated allografts. Single cell suspensions were obtained from allografts after dispase digestion. FACS, fluorescence-activated cell sorting; IF, immunofluorescence. * p < 0.05</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24766_coac004f2.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Characterization of red panda eMSCs. ( A ) RT-PCR analysis of pluripotency genes in eMSCs. beta-actin was used as a control for RNA sample quality. ( B ) The expression of SOX2 was detected in red panda eMSCs and skin FCs by western blot. GAPDH was used as the loading control. ( C ) Red panda eMSCs were stained with phycoerythrin (PE)-conjugated CD44, CD49f, CD105, CD34 or PE-Cyanine7 conjugated CD31 antibodies. Blue areas, signal from isotype controls; red areas, signal from the specific cell surface marker; grey areas, unstained black control.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19129_fonc-12-816894-g005.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 5 CD44 protein expression analyzed by flow cytometry. (A) CD44 regulation by ruxolitinib treatment. The CD44 expression profiles of ruxolitinib-treated myxoid liposarcoma (MLS) 402-91 cells compared with control cells treated with DMSO are shown as an example (left panel). Mean CD44 expressions in ruxolitinib-treated MLS (402-91, 2645-94, and 1765-92) and fibrosarcoma [HT1080 wild-type (WT), HT1080 EGFP, and HT1080 FUS-DDIT3-EGFP] cells are shown (right panel). **** p < 0.0001, paired Student's t -test. (B) CD44 regulation by anoikis resistance. The CD44 expression profiles of anoikis-resistant MLS 402-91 cells in comparison to control cell cultures in monolayer are shown as example (left panel). Mean CD44 expressions in anoikis-resistant cells compared with control cells for MLS (402-91, 2645-94, and 1765-92) cells are shown (right panel). * p < 0.05, paired Student's t -test.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20582_41467_2022_28438_Fig4_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 4 N2-converted neutrophils inhibit T cell proliferation, activation and Th1 differentiation. a Representative flow cytometry plots and percentage of the indicated T cell subsets in the pre-metastatic lung ( n = 6 mice in each group). b CFSE-labeled CD4 + or CD8 + splenocytes were stimulated with anti-CD3/CD28 antibodies and mixed without (BLANK) or with neutrophils purified from lungs of tumor-bearing mice. The percentage of proliferating T cells is shown ( n = 6 culturing experiments). c CFSE-labeled OT-1 splenocytes (CD8 + ) were mixed with OVA 257-264 -pulsed bone marrow-derived DCs and neutrophils as in panel b. The percentage of proliferating T cells is shown ( n = 6 culturing experiments). d CD4 + and CD8 + T cells in the pre-metastatic lung were subjected to CD44 and CD62L staining. Representative contour plots and summary data were shown ( n = 6 mice in each group). e The expression of IFN-gamma and TNF-alpha were analyzed in CD4 + and CD8 + T cells in the pre-metastatic lung ( n = 6 mice in each group). f CD4 + and CD8 + T cells were purified from naive mice's spleen stimulated with anti-CD3/CD28 antibodies and mixed with the indicated neutrophils. Twenty-four hours later, the cell fraction adopting a CD44 + CD62L - phenotype was determined by flow cytometry ( n = 6 culturing experiments). g Naive CD4 + T cells were stimulated under Th1-stimulating conditions in the presence of the indicated lung neutrophils. Four days later, the cells were re-stimulated with PM</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19128_fonc-11-780410-g007.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 7 SLC27A6 expression positively correlates with CD24 and CD44 expression level in NPC cells. (A) Positive correlation between the mRNA expression of SLC27A6 and CD24 in NPC cells (HONE1, R=0.95; 5-8F, R=0.99) by qRT-PCR. (B) No significant difference was shown between the SLC27A6 and CD34 mRNA expression in HONE1 (left panel), while a negative correlation was seen in 5-8F (right panel). (C) Positive correlation between the mRNA expression of SLC27A6 and CD44 in NPC cells (HONE1, R=0.98; 5-8F, R=0.97) by qRT-PCR. (D) The CD44 expression levels in HONE1 (left panel) and 5-8F (right panel) stably transfected cells were measured by flow cytometry. NS, no significance > 0.05; * P < 0.05; ** P < 0.01; *** P < 0.001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19126_41419_2021_4394_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 2 GPR120 reduced CD4 + T cell responses in mice with liver injury. Wild-type (WT) and GPR120 -/- (GPR120 KO) mice were injected with P. acnes (P.ac). Vehicle or TUG891 (10 mg/kg) was administered i.p. to WT mice on days 0, 2, 4, and 6 after P. acnes injection. Livers and spleens were isolated on day 7 ( n = 7 mice per group). a Absolute numbers of total MNCs in livers and spleens were analyzed by flow cytometry. b Percentages of CD4 + T cells in total MNCs in livers and spleens were analyzed by flow cytometry. c The expression levels of CD44 and CD62L in CD4 + T cells in the livers and spleens were analyzed by flow cytometry. d On day 6 after priming, BrdU was injected i.p. into the mice. MNCs were isolated from livers and spleens the next day. Cells were stained for CD4 and BrdU. The frequencies of CD4 + BrdU + T cells in the livers and spleens were determined by flow cytometry. e The percentages of TNF-alpha + , IFN-gamma + , and Foxp3 + cells in CD4 + T cells were assessed by intracellular staining and flow cytometry. f The levels of serum TNF-alpha, IFN-gamma, IL-4 and IL-10 were measured by enzyme-linked immunosorbent assay. The results are representative of three to six independent experiments and presented as the mean +- SEM. Significant differences were analyzed by One-way ANOVA. * p < 0.05, ** p < 0.01, *** p < 0.001, ns no significance.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19126_41419_2021_4394_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 3 GPR120 had no effects on the activation, proliferation, and differentiation of CD4 + T cells in vitro. T cells were isolated from the spleens of wild-type (WT) mice and GPR120 -/- (GPR120 KO) mice. T cells were cultured (2 x 10 5 cells/well) in the presence of anti-CD3 and anti-CD28 antibodies. T cells from WT mice were treated with DMSO, TUG891 (20 muM) with or without AH7614 (20 muM). a , b The expression levels of CD25, CD44, CD62L, and CD69 on CD4 + T cells were analyzed by flow cytometry. c , d Frequencies of the proliferating (CFSE low ) CD4 + T cell proliferation in response to the indicated treatments were measured by flow cytometry. e , f CD4 + T cells were stained for the surface marker CD4 and intracellular expression of TNF-alpha and IFN-gamma on day 5 and analyzed by flow cytometry. g , h CD4 + T cells were stained for the surface marker CD4 and intracellular expression of Foxp3 on day 5 and analyzed by flow cytometry. The results are representative of three independent experiments and presented as the mean +- SEM. Significant differences were analyzed by One-way ANOVA. ns no significance.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19027_41467_2021_27485_Fig5_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 5 QD-Cat-RGD-based RT for promoting DC maturation and antigen presentation in TDLNs and consequently inducing T cell-driven antitumor immunity. a Representative flow cytometric analysis images and relative quantification of co-stimulatory molecules CD80 + CD86 + gating on CD45 + CD11c + cells in TDLNs. b Representative flow cytometric analysis images and relative quantification of MHC-II expression on CD11c + CD45 + cells in the TDLNs. c Representative flow cytometric analysis images and relative quantification of CD3 + T cells gating on CD45 + in tumors. d Representative immunofluorescence images of tumors showing CD8 + T cells and relative quantification of CD8 + CD3 + T cells gating on CD45 + cells in tumors by flow cytometry. Scale bars = 50 mum. The immunofluorescent images were representative of those generated from three mice each group. e Representative flow cytometric analysis images and relative quantification of CD44 + CD62L + Tcm cells gating on CD8 + CD3 + CD45 + cells in the TDLNs. All data are presented as the mean +- s.e.m. ( n = 5 per group) and n represents the number of independent animals. Statistical significance was calculated via one-way ANOVA with Tukey's multiple comparisons test. FMO fluorescence-minus-one. TDLN tumor-draining lymph node. Source data are provided as a Source Data file.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19124_gr1.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1 Deletion of CD95 in 4T1 cells inhibits tumor growth and cancer stemness in BALB/c mice but not in NSG mice (A) Wild-type (vCas9) or CD95 k.o. 4T1 (mixture of clones #54 and #69) cells (10 5 ) were injected into the fat pad of NSG mice. Bioluminescence of tumors was quantified at the indicated times after injection of cells. (B and C) Equal numbers of WT (Parental or vCas9) or CD95 k.o. (#54 or #69) 4T1 cells were transplanted into the mammary fat pad of NSG mice, and tumor weight (B) and tumor volume (C) were measured after two weeks. (D) Wild-type (mixture of clones #3 and #4) or CD95 k.o. 4T1 (mixture of clones #10 and #12) cells (10 5 ) were injected into the mammary fat pad of NSG mice, and tumor volume was measured using a caliper. (E) ALDH1 activity and CD44 surface staining of single-cell suspensions of tumors isolated from NSG mice. n = 3 for each group. (F) IHC quantification of Ly6G positive cells in the WT and CD95 k.o. tumors monitored in (B). n = 3 biological replicates. (G) Equal numbers of WT (Parental or vCas9) or CD95 k.o. (1:1 mixture of #54 or #69) 4T1 cells were transplanted into the mammary fat pad of NSG mice, and tumor nodules of the primary tumor on the surface of the lungs were counted two weeks after transplantation. (H) The appearance of representative lungs analyzed in (G). Scale bar, 5 mm. (I) Luciferase expressing wild-type (cCas9) or CD95 k.o. 4T1 (mixture of two k.o. clones) cells (10 5 ) were injected into the mammary fat pad of BALB/</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19127_jci-132-146071-g051.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 5 TNF superfamily members CD153 and CD30 are specifically expressed in SAT cells and ABCs, respectively, inside of TLTs in aged injured kidneys. ( A ) Dot plot of ligand-receptor interactions related to TNF superfamily members between 6 CD4 + T cell subpopulations and 3 B cell subpopulations identified by scRNA-Seq (see Figure 3 ). ( B ) Violin plots showing the expression of Tnfsf8 and Tnfrsf8 in all CD45 + cells. The putative identities of each cluster are specified in the box. DN, double-negative. ( C ) UMAP plot of Tnfsf8 and Tnfrsf8 in CD45 + cells in Figure 2B and enlargement of those of Cd4 , Tnfsf8 , Spp1 , Sostdc1 , Il21 , and Il10 , and those of Cd19 , Cr2 , Tbx21 , and Tnfrsf8 . ( D ) Representative FACS plots of CD153 expression on T cells, B cells, macrophages, dendritic cells, CD4 + T cells, CD8 + T cells, CD44 hi CD4 + T cells, and PD-1 + CD4 + T cells ( n = 3/group). ( E ) Representative FACS plots of CD30 expression on T cells, B cells, macrophages, and dendritic cells ( n = 2/group). ( F ) Plasma soluble CD30 (sCD30) levels of young and aged mice with or without (not treated, NT) ischemic reperfusion injury (IRI) induction ( n = 3/group, samples were collected 45 days after IRI). Data are presented as mean +- SD. Statistical significance was determined by 1-way ANOVA with Bonferroni's post hoc analysis. *** P < 0.001. ( G ) Violin plots showing the expression of Adam10 and Adam17 among 3 B cell subsets identified by scRNA-Seq. ( H ) Representative ISH</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19123_fimmu-12-726393-g001.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1 Homozygous RhoA deletion in Treg cells leads to early, fatal spontaneous inflammatory disorders. (A) Survival outcome of RhoA +/+ Foxp3 YFP-Cre and RhoA Flox/Flox Foxp3 YFP-Cre mice. Results were analyzed with a log-rank (Mantel-Cox) test and expressed as Kaplan-Meier survival curves. (B) Image of lymphadenopathy in RhoA Flox/Flox Foxp3 YFP-Cre mice. Inguinal lymph nodes are shown. (C) Images of H&E staining of the indicated organs from RhoA +/+ Foxp3 YFP-Cre and RhoA Flox/Flox Foxp3 YFP-Cre mice (original magnification X 400). (D) Left, representative flow cytogram of CD44 and CD62L staining in CD4 + and CD8 + cells from the spleen of RhoA +/+ Foxp3 YFP-Cre and RhoA Flox/Flox Foxp3 YFP-Cre mice. The numbers indicate percentages of CD44 + , CD44 + CD62L + , and CD62L + cells. Right, average percentages of CD44 + , CD44 + CD62L + , and CD62L + cells. (E) Left, representative flow cytogram of IL-17, IFN-gamma, and IL-4 staining in CD4 + Foxp3 - cells from the spleen of RhoA +/+ Foxp3 YFP-Cre and RhoA Flox/Flox Foxp3 YFP-Cre mice. The numbers indicate percentages of IL-17 + , IFN-gamma + , and IL-4 + cells. Right, average percentages of IL-17 + , IFN-gamma + , and IL-4 + cells. (F) Left, representative flow cytogram of RORgammaT, T-bet and GATA3 staining in CD4 + Foxp3 - cells from the spleen of RhoA +/+ Foxp3 YFP-Cre and RhoA Flox/Flox Foxp3 YFP-Cre mice. The numbers indicate percentages of RORgammaT + , T-bet + , and GATA3 + cells. Right, average percentages of RORgam</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24759_gr2.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Experimental strategy and data example (Left) Experimental strategy for FACS analysis (A), co-culture analysis (B) and hematopoietic potential analysis (C). (Right) Representative experimental data. Scale bars, 50 mum.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19088_nihms-1747909-f0004.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 3. Pik3cd E1020K/+ mice fail to develop a robust T CM population (A-F) Viable CD8 + splenocytes from mice infected with LCMV Armstrong (n = 2, 4-5/group/time point). (A-C) NP396-specific CD8 + cells day 15 p.i. (A) CD127 and KLRG1 expression (left: representative staining; right: %KLRG1 + CD127 - ). (B) Representative histogram of CD27 (top) and CD127 (bottom). (C) GzmB and TCF1 staining. Middle: TCF1 MFI; right: GzmB MFI. (D-F) NP396-specific CD8 + cells day 58 p.i. (D) CD44 and CD62L staining. Representative flow (left), % CD44 hi CD62L lo cells (right). (E) CD127 histograms: CD44 hi CD62L lo (top) and CD44 hi CD62L + (bottom). (F) TCF1 MFI. (G) TCF1 staining of allo-reactive CD8 + cells from healthy controls and patients with APDS (n = 2, representative histogram). (H-L) Mice were infected with X31 and challenged with PR8 (n = 2, 3-5 mice/genotype/time point). (H) Infection outline. (I) PA224-specific CD8 + cell numbers. (J) IFN-gamma and TNF-alpha from day 8 cells stimulated with either PA 224-233 (left) or anti-CD3 plus anti-CD28 (right). (K) NP366-specific CD8 + T cell numbers. (L) IFN-gamma and TNF-alpha from day 35 cells stimulated with either NP 366-374 (left) or anti-CD3 plus anti-CD28 (right). (M-O) OT-1 cells were transferred into congenic hosts, infected with influenza X31-OVA and challenged with PR8-OVA (n = 2, 3 mice/genotype/time point). (M) Outline. (N) Viable OT-1 cell numbers. (O) TCF1 and GzmB expression in OT-1 cells on day 35. Representative exper</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19122_cancers-13-04917-g005.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 5 Forced expression of miR-125b-5p or knockdown of ATXN1 gene increases migration, invasion capability, and cancer stemness of HCC cell lines. ( a ) Representative image of the wound-healing assay in PLC/PRF5-miNC, PLC/PRF5-miR125b, and PLC/PRF5-R2-miNC cells (upper panel). The average migration distance was calculated from the wound healing area, and the time-dependent distance of migration is depicted in the lower panel (mean +- SD; n = 3). ( b ) Similarly, representative images of the wound-healing assay and time-dependent distance of migration in PLC/PRF5-siNC, PLC/PRF5-siATXN1, and PLC/PRF5-R2-siNC cells are shown in the lower panel (mean +- SD; n = 3). ( c ) Representative images of the invasion assay in PLC/PRF5-miNC, PLC/PRF5-miR125b, and PLC/PRF5-R2-miNC cells (left panel). The number of invading cells was counted, and the average numbers of invading cells are shown (right panel). ( d ) Similarly, representative invasion assay images and quantified invading cells in PLC/PRF5-siNC, PLC/PRF5-siATXN1, and PLC/PRF5-R2-siNC cells are shown. ( e ) Expression of CD44 and CD133 in PLC/PRF5-miNC and PLC/PRF5-miR125b cells was evaluated by two-color flow cytometry using mouse anti-human CD44 monoclonal antibody (APC) and mouse anti-human CD133 monoclonal antibody (PE). The percentage of CD44 + CD133 + cells based on the analysis of 10,000 cells is indicated. ( f ) Expression of CD44 and CD133 in PLC/PRF5-siNC and PLC/PRF5-siATXN1 cells was analyzed by flow cytometry and</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19125_nihms-1746308-f0006.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 5. Rac1 inhibition enhances thymus regeneration and peripheral CD4 + naive T cell recovery after acute damage 6- to 8-week C57BL/6 WT or Nod2 -/- mice were treated with the Rac1 inhibitor EHT1864 (40 mg/kg i.p. injection) at days 3, 5, and 7 following a sublethal dose of TBI (550 cGy), and the thymus was analyzed on day 14. (A) Total thymic cellularity at day 14 after SL-TBI (WT, n = 20/treatment across 4 independent experiments; KO, n = 9-12 across three independent experiments). (B) Flow plots showing CD4 and CD8 expression at day 14 after SL-TBI (gated on CD45 + cells; plots were concatenated of all samples in each treatment group from one experiment). (C) Total number of DP, SP4, or SP8 thymocytes (n = 20/treatment across 4 independent experiments). (D) Expression of miR29c analyzed by qPCR on whole thymic tissue (n = 5/group). (E) Total thymic amounts of BMP4 and IL-23 assessed by ELISA at day 7 (n = 4-5/group, representative of two independent experiments). (F) Total number of cTECs and mTECs (n = 15/group across three independent experiments). (G) Flow plots showing CD4 and CD8 expression in the spleen at day 56 after SL-TBI (gated on CD45 + CD3 + cells). (H) Total number of CD4 + and CD8 + T cells in the spleen at d56 (n = 5/group). (I) Plots of CD62L and CD44 on CD4 + and CD8 + T cells (gated on either CD45 + CD3 + CD4 + CD8 - or CD45 + CD3 + CD4 - CD8 + ) cells; plots concatenated of all samples in a given experiment). (J) Ratio of number of naive (CD62L hi C</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14839_41467_2021_25990_Fig5_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 5 HGF induced an effective therapeutic effect against B16F10 tumor. a Schematic illustration of the experiment design to assess the tumor inhibition and the immune responses as triggered by PBS, HACA-Fe, HACA-GW, or HGF NPs on subcutaneous B16F10 tumor model. G1, PBS; G2, HACA-Fe; G3, HACA-GW; G4, HGF. b and c Tumor growth curves during treatment. d Survival rates of different groups over time. e and f Representative flow cytometry plots and quantification of e CD8 + f and CD4 + T cells after gating on CD45 + CD3 + T cells in tumor tissue. g and h Representative flow cytometric analysis of memory T cells (CD3 + CD8 + CD44 + CD62L - , gated on CD3 + CD8 + T cells) in the spleen. Data were presented as mean +- SD. n = 5 biologically independent animals per group. Statistically significant differences between groups were identified by one-way ANOVA with Tukey's post hoc test. * P < 0.05, ** P < 0.01, *** P < 0.001 and **** P < 0.0001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14887_gr6.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 6 Assessments of organ damage and mouse metabolites during HLSA or recovery from HLSA. A , upper left panel , MMP-1, IL-1beta, and CRP levels in plasma had no significant change between the control group, HLSA group, and R-HLSA group. Upper right panel , CK-MB as a marker of heart injury in the plasma had no significant change between the control group, HLSA group, and R-HLSA group. Lower left panel , creatinine and BUN as markers of kidney injury in the plasma slightly increased in the HLSA group and returned to normal level after recovery from HLSA. Lower right panel , AST and ALT as markers of liver injury in the plasma showed no change between the control group, HLSA group, and R-HLSA group. Data were presented as mean +- SD (N = 6; ANOVA: ** p < 0.01). B , upper panel , food consumption and water consumption 3 days before and 3 days after a single ATP-induced HLSA depicted no change. Data were presented as mean +- SD (N = 6; ANOVA: p > 0.05). Lower panel , metabolomics analysis of scores plot from PCA analysis based on 1 H NMR data from the plasma, brain, liver, and kidney of the control group, HLSA group, and R-HLSA group. The PCA score showcased clusters correspond to metabolic patterns in different groups, with each point representing one sample. Circles represent 95% confidence interval for each score in each group (see also Figs. S5-S8 ). C , draining lymph nodes of mice that underwent HLSA once a day for 10 consecutive days were analyzed with FACS. CD44 and</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15151_JEM_20201631_FigS2.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure S2. Mechanism of action of IRS661. (A) Schematic representation of the experimental setup. Mice were infected intranasally with 1,000 TCID 50 of influenza virus X31 and treated with IRS661 or PBS intranasally (15 nmol in 30 ul) on day 4 after infection. Usually, BALF was isolated on day 6 after infection. Colored dots mark days when mice were treated with alphaPDCA-1 (200-500 ug), 1A8 (150-300 ug), alphaSiglec-H (200-500 ug), or alphaCCR2 (20 ug) depletion antibody i.p. (B) WT 129S7 mice were infected with X31 and treated with IRS661 or PBS intranasally (15 nmol in 30 ul), i.p. (50 nmol in 100 ul), or intravenously (50 nmol in 100 ul) 4 d later. IFN-alpha concentrations were quantified by ELISA in BALF taken on day 5 after infection. n = 3-11 mice per group. (C) Flow cytometry plots representing the gating strategy for cell analysis in Fig. 2 B . Lineage channel includes CD3, CD19, and NKp46. FSC, forward scatter; SSC, side scatter. (D) WT 129S7 mice were infected with 1,000 TCID 50 X31 and treated with IRS661, control ODN 2, or PBS intranasally. Survival was monitored for 14 d. n = 17-18 mice per group. (E and F) Viral loads in lungs of X31-infected mice treated with IRS661 or PBS (E; n = 3-7 mice per group) and/or aPDCA-1 antibody (F; n = 6-7 mice per group) were determined by RT-qPCR or TCID 50 assay at days 2, 3, 5, and 7 (E) or day 6 (F) after infection. (G) WT C57BL/6 mice were infected with 10,000 TCID 50 X31 and treated with IRS661 or PBS intranasally. Survival</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14941_ADVS-8-2101848-g005.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 2 CD10 in CAFs sustains cancer stemness and chemoresistance. A-E) Indicated tumor cell lines were cultured alone (-) or cocultured with CD10 + GPR77 + -depleted CAFs (CD10 + GPR77 + -d) or paired CD10 + GPR77 + CAFs transduced without (-) or with shGFP or shCD10. A) Representative images of mammosphere formation in MCF-7 cells. Scale bar, 100 um. B) Representative images of PKH26 and Numb immunofluorescence staining of MCF-7 cells. Scale bar, 50 um. C,D) Percentage of ALDH1 + cells in C) MCF-7 and D) BT-549 cells detected by flow cytometry. Numerical values are presented as percentage (mean +- SEM, n = 3). E) Percentage of CD44 high CD24 low cells in MCF-7 cells cocultured with indicated CAFs was detected by flow cytometry. Numerical values are presented as percentage (mean +- SEM, n = 3). F,G) Representative flow cytometry plots for F) MCF-7 and G) BT-549 cells treated with docetaxel after being cultured alone (-) or cocultured with the indicated CAFs. The proportion of Annexin V + /Propidium iodide - (early apoptosis) and Annexin V + /Propidium iodide + (late apoptosis) cells is shown. The numerical values indicate Annexin V + percentage. Data are represented as the mean +- SEM of F) n = 4 or G) n = 3 independent experiments. H) Representative immunoblots for cleaved/total caspase-3 and PARP in SK-BR3 cells treated with docetaxel after being cultured alone (-) or cocultured with indicated CAFs ( n = 3). I-L) MCF-7 cells were cocultured with CD10 + GPR77 + CAFs or CD1</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15143_fcell-09-695015-g007.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">FIGURE 7 r Ts Pmy maintains majority of Tregs in an effective suppressor status (CD62L lo CD44 hi eTregs) with greater expression of functional phenotypes of TIGIT and CTLA4 in cLP with DSS-induced colitis. Flow cytometry results showed the frequencies of CD44 hi CD62L lo cells (A) and TIGIT + cells (B) in CD4 + Foxp3 + T cells of cLP from r Ts Pmy or PBS-treated mice with or without DSS colitis. The blank control of antibodies of CD62L and CD44 (A) was shown, and the antibody of TIGIT (B) were cut in FMO control samples. The corresponding percentages are shown on the right ( n = 5). (C) The frequency of Foxp3 + CTLA4 + cells in CD3 + CD4 + T cells. The antibody of CTLA4 was cut in FMO control samples. The corresponding percentage is shown on the right ( n = 3-5). The bars represent the mean +- SEM. * p < 0.05. cLP, colonic lamina propria.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15142_41420_2021_561_Fig5_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 5 The 3-HAA increases the sensitivity of HCC cells to sorafenib by suppressing stemness. A The cell viability of 3-HAA-treated SMMC-7721 and PLC8024 cells was analyzed by CCK8 assay. Cells were treated with sorafenib at the indicated dose with or without 100 muM 3-HAA for 4 days. * P < 0.05. B The combination of 3-HAA and sorafenib dramatically inhibited ALDH, SOX2, and OCT4 expression in SMMC-7721 and PLC8024 cells. Cells were treated with 100 muM of 3-HAA and sorafenib at the indicated dose for 24 h. C The combination of sorafenib and 3-HAA significantly reduced the proportion of CD133 + CD44 + tumor cells than either 3-HAA alone or sorafenib alone in SMMC-7721 and PLC8024 cells. Cells were treated with 100 muM 3-HAA and 5 muM sorafenib for 24 h. * P < 0.05, ** P < 0.01. D CHIR99021 recovered the AKT/GSK3beta/beta-catenin signaling and the expression of stemness markers, inhibited by the combination treatment. Cells were treated with 100 muM 3-HAA, 5 muM sorafenib, and/or 5 muM CHIR99021 for 24 h. E CHIR99021 recovered the combination-suppressed tumor growth of SMMC-7721 xenografts. 3-HAA and sorafenib were separately administrated by intraperitoneal injection for 16 days at the dose of 100 and 10 mg/kg day, respectively. CHIR99021 was administered orally at 40 mg/kg day, five mice were recruited in each group. The tumor volumes are presented as mean +- SD. ** P < 0.01. F CHIR99021 increased the ratio of CD44 + CD133 + subpopulation in SMMC-7721 xenografts. Tumor cells</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15142_41420_2021_561_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 3 3-hydroxyanthranic acid inhibits tumor stemness of sorafenib-resistant HCC cells. A 3-HAA inhibited cell growth of sorafenib-resistant HCC cells. Cell numbers of HCC cells were counted by cytometry. Data were presented as mean +- SD ( n = 3). * P < 0.05, ** P < 0.01. B 3-HAA reduced colony formation in sorafenib-resistant SMMC-7721 and PLC8024 cells. Cells were treated with 3-HAA at the indicated dose. * P < 0.05, ** P < 0.01. C The ratio of CD44 + CD133 + subpopulation was decreased in 3-HAA-treated SMMC-7721 and PLC8024 cells. Cells were treated with 3-HAA at the dose of 100 muM for 48 h. * P < 0.05. D 3-HAA inhibited the expression of stem cell markers in HCC cells. The treating time was 48 h for the dose-response experiment and the dose of 3-HAA was 100 muM for the time-course analysis. E 3-HAA suppressed tumor growth of SMMC-7721 xenografts. The 3-HAA was administrated 100 mg/kg day by intraperitoneal injection for 16 days, five mice were recruited in the control and 3-HAA-treated group. The tumor volumes were presented as mean +- SD. * P < 0.05. F 3-HAA decreased the proportion of CD44 + CD133 + subpopulation in SMMC-7721 xenografts. Tumor cells were analyzed by flow cytometry using anti-CD133-PE and anti-CD44-APC. * P < 0.05. G 3-HAA inhibited the expression of stem cell markers in SMMC-7721 xenografts. Bar = 100 mum.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15142_41420_2021_561_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Tumor stemness is increased in sorafenib-resistant hepatocellular carcinoma cells. A SMMC-7721 and PLC8024 cells were more resistant to sorafenib than HepG2 and Hep3B cells. HCC cells were treated with 0-40 muM sorafenib and the cell viability was analyzed by the CCK8 assay. Data were presented as mean +- SD ( n = 3). B The KEGG analysis on the upregulated/downregulated genes. The genes expression changed more than 2 folds were analyzed between sorafenib-resistant vs. sorafenib-sensitive HCC cells. C Heatmap of gene expression participated in cell cycle pathway, Wnt signaling, and PI3K-AKT pathway. The levels of the gene expression were reflected by different colors, colors from blue to red stood for expression levels from low expression to high expression. D The expression of stem cell markers was enhanced in sorafenib-resistant HCC cells. The expression of ALDH, SOX2, and OCT4 was analyzed. E The CD44 + CD133 + subpopulations were increased in sorafenib-resistant HCC cells. The CD44 + CD133 + subpopulation was analyzed by flow cytometry using anti-CD44 and anti-CD133 antibodies. * P < 0.05, ** P < 0.01. F Stemness was increased in sorafenib-resistant HCC tumors. OCT4 and NANOG expression were detected by IHC. Bar = 100 mum.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15141_41419_2021_3936_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Mesodermal progenitors can be derived trough a chemically defined monolayer approach. A Schematic overview of the protocol to differentiate induced pluripotent stem cells towards mesodermal progenitors. B - D Gene expression of markers for pluripotency, early and late mesoderm, ectoderm, and endoderm during mesoderm differentiation. E FACS analysis of Mesogenin1 (MSGN1) during differentiation using a MSGN1-2A-Venus reporter line. F Percentage of MSGN1, CD44, and CD140A/B positive cells during differentiation, based on FACS analysis. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. n = 3-4.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15140_gr5.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 5 Impact of Mito-MGN on T cell activation and effector functions (A) Schematic for analyzing Mito-MGN effects on splenic T cells. (B-D) Changes in T cell activation. Representative flow cytometry plots of CD44 hi CD62L lo levels in T cells (B). Enumeration of activated T cells of CD4 + (C) and CD8 + (D) T cell subsets in Mito-MGN treated and vehicle control cells. Values are mean +- SD, n = 6 independent experiments. Statistical significance determined using a Student's t-test (**, p< 0.01; ***, p< 0.001). Effects of Mito-MGN on T cell proliferation and early activation markers are shown in Figure S8 . (E) Realtime measurement of extracellular acidification rate (ECAR) (left panel) and oxygen consumption rate (OCR) in treated T cells Values are mean +- SD of n = 3 biological replicates completed in technical quadruplicate. Statistical differences at individual time points were analyzed using Student's t-test (****, p< 0.0001). (F and G) IsoPlexis IsoLight assay measured Polyfunctionality Strength Index (PSI) scores (F) and effector or inflammatory cytokine levels (G) in Mito-MGN treated compared to vehicle control T cells. Values are mean +- SD from 2 biological replicates.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12510_gr2.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 2 CD25 expression on tumor-infiltrating lymphocytes. (a) Tumor-infiltrating lymphocytes were analyzed with flow cytometry. Tregs accounted for 49.8% of CD4 + T cells. (b) 71.5% of CD25 positive cells were CD3 + CD4 + Foxp3 + Tregs (c) Upper: Surface expression of CD25 was evaluated for NK cells, CD8 + T cells, CD4 + Foxp3 - T cells, and CD4 + Foxp3 + Tregs. Lower: CD4 + Foxp3 + Tregs showed significantly higher mean fluorescence intensity (MFI) of CD25 (left) and CD25 positive percentage (right) ( n = 4; one-way ANOVA followed by Tukey''s test; ****, p < 0.0001). Fig 2</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15116_fimmu-12-642420-g003.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 3 Paclitaxel dysregulates CD4 + and CD8 + T-cell subpopulations in an eIF4E-dependent manner. (A) Gating strategy used for flow cytometry of lymphocytes from popliteal and inguinal lymph nodes. T-cells were separated from the whole lymphoid cells population using CD3. CD3 + cells were then gated for CD4 + T-cell and CD8 + T-cells. For each of these subsets, cells were further gated for CCR7 or CD25 and CD44. (B) Quantification of CD4 + T-cells from the CD3 population from male mice. (C) CCR7 + T-cells from isolated CD4 + population in males, ** p 0.0063. (D) CD4 + cells gated for CD25 and/or CD44 in males. (E) Quantification of CD4 + T-cells from the CD3 + population from female mice, * p 0.0101. (F) CCR7 + T-cells from isolated CD4 + population in female mice, * p 0.0250. (G) CD4 + cells gated for CD25 and/or CD44 in female mice, ** p 0.0011. (H) Quantification of CD8 + T-cells from the CD3 + population from male mice. (I) CCR7 + T-cells from isolated CD8 + population in males, * p 0.0433. (J) CD8 + cells gated for CD25 and/or CD44 in males, * p 0.0396. (K) Quantification of CD8 + T-cells from the CD3 population from female mice, * p 0.041. (L) CCR7 + T-cells from isolated CD8 + population in female mice, ** p 0.0097. (M) CD8 + cells gated for CD25 and/or CD44 in female mice. All data are presented as mean +- standard error of the mean, n = 3 mice each for male/female WT vehicle-treated and WT paclitaxel groups, n = 4 mice each for male/female eIF4E S209A vehicle-trea</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15139_apb-11-361-g001.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1 AD-MSCs characterization; (A) Flow cytometry assay to assess the CD markers in the surface of extracted AD-MSCs. Target cells were positive for CD73 (95.1%), and CD90 (90.6%) surface markers and were negative for CD44 and CD34 markers. (B) Morphology of AD-MSCs at passage 3. (C) Oil red staining to prove the adipogenic potential differentiation of AD-MSCs. (D) Alizarin-red staining to confirm the osteogenic potential differentiation of AD-MSCs. Scale bar = 100 mum. Abbreviations: AD-MSCs: adipose-derived mesenchymal stem cells.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15145_EMS117746-f006.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 6 Enhanced chromosomal instability induced by MSL disruption exhausts cancer cell proliferative capacity. a . Clonogenic assays comparing MSL LOF ( MSL3 -KO) and control TDF cells visualized by crystal violet staining. Scale bar: 1 mm. b . DNA FISH detecting the pericentromeric region of chromosome 12 in clonal populations grown for 14 d. Cells from distinct locations within the clones are juxtaposed. Scale bar: 10 mum. c-d . Quantification of CIN score ( c ) and relationship with clone size ( d ). N = 105, 96, 121 biologically independent clones collected from two experiments. Horizontal lines: median values. P-value from one-way ANOVA followed by Tukey's test ( c ) and two-sided Spearman correlation test (MSL LOF cells in d ). N.s. : non-significant (p-value > 0.99). R s : correlation coefficient for MSL LOF cells. e-h. Immunodetection of Ki67 ( e , g ) and quantification of non-proliferative Ki67-negative cells ( f , h ). N = 100, 102, 130, 1375, 1300 independent cells for DMSO, 4d and 6d reversine, cntr-KO and MSL LOF ( MSL3 -KO) cells collected from two experiments. MEXF-2090 cells are shown in g - h ; TDF and other PDX-derived cells showed similar results. P-value from two-tailed Fisher's exact test. Scale bar: 10 mum. i-j . Limiting dilution clonogenic assays. Phase contrast images of DMSO- and reversine-treated TDF cells 12 d after plating ( i ) and quantification of populated wells ( j ). The percentage of wells containing at least one clone larger than 20 cel</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15147_biol-13-129-g002.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 2 The proportion of CD8 + effector memory T (Tem) cells and levels of IFN-gamma, mTOR and S6K in CD8 + Tem cells were significantly increased by IL-12 stimulation but significantly decreased by rapamycin treatment. The peripheral blood mononuclear cells obtained from the cyclophosphamide plus invasive pulmonary aspergillosis (CTX + IPA) mice, CTX + IPA mice treated with IL-12 (CTX + IPA+IL-12) or rapamycin (CTX + IPA+RAPA), and control animals were assessed using flow cytometry seven days after A . fumigatus infection. The side scatter (SSC) and CD8a were applied to gate on CD8 + T lymphocytes, CD44 + CD45 + CD62 +/- were considered to represent the Tem cells. Representative dot plots are shown, and the percentages of Tem cells and of Tem cells expressing IFNgamma, mTOR, and S6K are expressed as the mean +- S.D. * p < 0.05; ** p < 0.01; *** p < 0.001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15147_biol-13-129-g003.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 3 IL-12 significantly increased the expression of T-bet but significantly decreased the expression of Eomesodermin in CD8 + effector memory T (Tem) cells, which was blocked by rapamycin treatment. The peripheral blood mononuclear cells obtained from the cyclophosphamide plus invasive pulmonary aspergillosis (CTX + IPA) mice, CTX + IPA mice treated with IL-12(CTX + IPA+IL-12) or rapamycin (CTX + IPA+RAPA), and control animals were assessed using flow cytometry seven days after A . fumigatus infection. The side scatter (SSC) and CD8a were applied to gate on CD8 + T lymphocytes, CD44 + CD45 + CD62 +/- were considered to represent the Tem cells. Representative dot plots are shown, and the percentages of Tem cells and of Tem cells expressing T-bet and Eomesodermin are expressed as the mean +- S.D. * p < 0.05; ** p < 0.01; *** p < 0.001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15050_fcell-09-637424-g002.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">FIGURE 2 T cell senescence in various adipose tissues of old mice. (A,B) Flow cytometric analysis of CD45 + CD3 + T cells in AT of young and old mice and their quantitation. (C,D) Representative flow cytometric analysis of CD44 subsets in T cells isolated from adipose tissue and their quantification. (E,F) Representative flow cytometry of CD28 + T cells in adipose tissue from young or old mice and their quantification. * P < 0.05; ** P < 0.01; *** P < 0.001 vs. young mice, n = 3~6 per group.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15137_12935_2021_1872_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 3 Expression levels of CD44 and EpCAM on KatoIII cells surface and the effect of transient transfection of miR-34a-5p mimic on these markers expression. a The flow cytometry analysis indicated that EpCAM and CD44 are expressed in almost all and ~ 97% of KatoIII cells, respectively. The expression of CD44 on KatoIII cells showed lower intensity than EpCAM expression. In addition, two sub-populations of EpCAM positive cells with different fluorescence intensity were observed in KatoIII cell line. b The frequency and MFI of EpCAM marker were compared between adhesive KatoIII cells dissociated from the flask using trypsin enzyme and non-adhesive KatoIII cells. Data showed that the use of trypsin enzyme for detachment of the adherent cells from the flask reduced the fluorescence intensity of EpCAM (116.5 +- 0.7), in comparison to the suspended cells (180 +- 5.65). But, the use of trypsin enzyme for detachment of the adherent cells had no effect on the frequency of EpCAM positive cells. c According to the flow cytometry analysis, transient transfection of the miR-34a-5p mimic at 25 nM had no effect on percentage of CD44 and EpCAM positive cells in KatoIII cells. MFI: Median Fluorescence Intensity</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15137_12935_2021_1872_Fig5_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 5 The effect of stable transfection of pre-mir-34a on the expression levels of CD44 and EpCAM markers. The flow cytometric detection illustrated that the percentage of CD44 + cells and the MFI of CD44 marker were significantly decreased in the KatoIII-pGFPC1-34a cells compared to the KatoIII-pGFPC1- empty cells. No difference was found in percentage of EpCAM + cells between these two stable cells. *p < 0.05; **p < 0.01. MFI: Median Fluorescence Intensity</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15138_EMMM-13-e13390-g003.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure EV3 Sporozoite surface antigen induces a greater effector CD8 + T-cell phenotype than EEF vacuolar membrane antigen C57BL/6 mice received 2 x 10 6 OT-I cells alone ( n = 2) or were additionally immunised with 10,000 gamma-radiation attenuated WT ( n = 3), CSP SIINFEKL ( n = 4) or UIS4 SIINFEKL ( n = 4) sporozoites intravenously. Spleens and livers were harvested either 14 or 42 days later, and proportions of CD8 + T cells expressing effector surface markers were quantified. Flow cytometry plots show representative percentages of CD8 + T cells co-staining K b -SIINFEKL and markers of effector phenotype (CD11a hi , CD49d hi , CD62L lo , CD44 hi ).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15123_urn-x-wiley-17574676-media-emmm202013390-emmm202013390-fig-0003ev.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">EV3 Figure Sporozoite surface antigen induces a greater effector CD8 + T-cell phenotype than EEF vacuolar membrane antigen C57BL/6 mice received 2 x 10 6 OT-I cells alone ( n = 2) or were additionally immunised with 10,000 gamma-radiation attenuated WT ( n = 3), CSP SIINFEKL ( n = 4) or UIS4 SIINFEKL ( n = 4) sporozoites intravenously. Spleens and livers were harvested either 14 or 42 days later, and proportions of CD8 + T cells expressing effector surface markers were quantified. Flow cytometry plots show representative percentages of CD8 + T cells co-staining K b -SIINFEKL and markers of effector phenotype (CD11a hi , CD49d hi , CD62L lo , CD44 hi ).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15148_pone.0247990.g004.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">10.1371/journal.pone.0247990.g004 Fig 4 Immunogenicity of C57BL/6 mice four weeks after the final immunization with ID93+GLA-LSQ. Mice were immunized with ID93 combined with GLA-LS containing different QS-21 doses (10, 2 or 0.4 mug). (A) The percent frequency of single-cytokine producing ID93-specific CD4+ T cells. Bars represent the mean of the group, with vertical lines indicating SD. Groups were compared for each cytokine using one-way ANOVA with Bonferroni's multiple comparison test, with * p <0.05, ** p <0.01, **** p <0.0001 versus ID93 alone, an exact p value is shown for values near significance; (B) percent of polyfunctional ID93-specific CD4+CD44+CD154+ T cells producing one or more cytokines. The data are represented as the percentage of CD4+CD44+CD154+ T cells producing one or more cytokines following ex-vivo stimulation with ID93; cytokine producing subsets are shown as stacked bars, with mean + SD of each subset. Comparisons of total cytokine producing cells between groups were performed using one-way ANOVA with Bonferroni's multiple comparison test, * p <0.05, ** p <0.01, **** p <0.0001; (C) percent CD4+ T cell cytotoxicity. Mean and SD, with individual mice, are shown. Comparisons between the groups were performed using one-way ANOVA with Bonferroni's multiple comparison test; ** p <0.01, *** p <0.001, **** p <0.0001 versus ID93 alone.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15148_pone.0247990.g006.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">10.1371/journal.pone.0247990.g006 Fig 6 Prophylactic protection with ID93+GLA-SE and ID93+GLA-LSQ in C57BL/6 mice. Mice were immunized with ID93 combined with different adjuvant formulations including SE, LS (liposomes), LSQ (liposomes+QS21), GLA-LS, GLA-LSQ, or GLA-SE. (A) The percent frequency of single-cytokine producing ID93-specific CD4+CD44+ T cells. Bars represent the mean of the group, with vertical line indicating SD. Groups were compared for each cytokine using one-way ANOVA with Bonferroni's multiple comparison test, with * p <0.05, **** p <0.0001 versus ID93 alone; (B) percent of polyfunctional ID93-specific CD4+CD44+CD154+ T cells producing one or more cytokines; cytokine producing subsets are shown as stacked bars, with mean + SD of each subset. Comparisons between groups were performed using one-way ANOVA with Bonferroni's multiple comparison test, * p <0.05, **** p <0.0001; (C) bacterial burden in the lung is represented as Log 10 colony forming units (CFU) 3 weeks after challenge with Mtb H37Rv, with individual mice and mean +/- SD shown. Comparisons between groups were performed using one-way ANOVA with Bonferroni's multiple comparison test, * p <0.05, ** p <0.01, **** p <0.0001 versus Saline; ^ p <0.05, ^^ p <0.01, ^^^^ p <0.0001 versus ID93.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15148_pone.0247990.g007.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">10.1371/journal.pone.0247990.g007 Fig 7 Enhanced TH1 immune responses following infection with Mtb H37Rv within the lungs of C57BL/6 mice immunized with ID93+GLA-SE and ID93+GLA-LSQ. Mice were immunized with ID93 combined with different adjuvant formulations including SE, LS (liposomes), LSQ (liposomes+QS21), GLA-LS, GLA-LSQ, or GLA-SE. Four weeks after the last immunization mice were challenged with a low dose aerosol of Mtb H37Rv. Three weeks after challenge mice were euthanized and lungs collected to assess the immune response. (A) The percent frequency of single-cytokine producing ID93-specific CD4+CD44+ T cells within the lung. Bars represent the mean of the group, with vertical line indicating SD. Groups were compared using one-way ANOVA with Bonferroni's multiple comparison test, * p <0.05, ** p <0.01, *** p <0.001, **** p <0.0001 versus ID93 alone; (B) percent of polyfunctional ID93-specific CD4+CD44+CD154+ T cells within the lung producing one or more cytokines; cytokine producing subsets are shown as stacked bars, with mean + SD of each subset. Comparisons between groups were performed using one-way ANOVA with Bonferroni's multiple comparison test, *** p <0.001, **** p <0.0001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15148_pone.0247990.g003.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">10.1371/journal.pone.0247990.g003 Fig 3 Enhanced protection against Mtb HN878 in CB6F1 mice with liposomal formulations. (A) Increased polyfunctional ID93-specific CD4+CD44+ T cells from the spleens of immunized CB6F1 mice four weeks after the final immunization. The data are represented as the percentage of CD4+CD44+CD154+ T cells producing one or more cytokines following ex-vivo stimulation with ID93; cytokine producing subsets are shown as stacked bars, with mean + SD of each subset. Comparisons of total cytokine producing cells between groups were performed using one-way ANOVA with Bonferroni's multiple comparison test. Down-inflected lines indicate * p <0.05 versus ID93+GLA-LSQ2 or ID93+GLA-LSQ3. (B) Four weeks after LDA infection with Mtb HN878, lungs were taken, and bacterial burden was determined. Bacterial load within the lung is represented as Log 10 colony forming units (CFU), with individual mice and mean +/- SD shown. Comparisons among groups were performed using one-way ANOVA with Bonferroni's multiple comparison test, * p <0.05, ** p <0.01, *** p <0.001, **** p <0.0001 versus Saline; ^ p <0.05, ^^ p <0.01, ^^^ p <0.001 versus BCG.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9883_ijms-22-01546-g001.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1 Characterization of bone marrow-derived mesenchymal stem cells (MSC) isolated from mTmG mice. ( A ) Plastic adherent cells were ex vivo expanded until passage 10, maintaining red fluorescent (RFP) expression throughout. ( B ) MSCs differentiated into osteogenic (alizarin red staining), adipogenic (oil red staining), and chondrogenic (alcian blue staining) lineages. Scale bars represent 200 um. ( C ) Flow cytometry analysis for immunophenotyping showed that MSCs, in passages 7-8, were positive for CD 29 (98.8%), SCA-1 (98.2%), CD 44 (6.02%), CD 90 (4.18%), and CD 105 (4.97%), and negative for CD34 (0.49%), CD 45 (1.37%), and CD 31 (0.05%).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0002.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 2. Ectopic expression of NIK prevents T cell exhaustion and promotes antitumor immunity. a-c , Tumor growth curve ( a ), image of day 32 tumors ( b ), and survival curve ( c ) of the MC38-bearing NIK iTg and wildtype control mice. d , e , Tumor growth ( d ) and survival ( e ) curves of NIK iTg and wildtype control mice injected s.c. with 5 x 10 5 B16F10 melanoma cells. f , g , Flow cytometric analysis of the frequency and absolute cell number of CD4 + and CD8 + T cells ( f ) and IFN-gamma-producing CD8 + effector T cells ( g ) in day-32 tumor of MC38-bearing NIK iTg and wildtype control mice ( f , g , n=6 per genotype). h-j , Flow cytometric analysis of the frequency and absolute cell number of CD4 + and CD8 + T cells in the draining lymph node ( h ) and CD44 + CXCR3 + CD8 + effector T cells in the draining lymph node ( i ) or tumor ( j ) of day-32 MC38-implanted NIK iTg and wildtype control mice ( h , n=6 per group; i , n=4 per group; j , n=3 per group). k , l , Flow cytometric analysis of the frequency and absolute cell number of PD1 + Tim3 + and PD1 + Tim3 - CD8 + T cells ( k ) and IFN-gamma-producing gated PD1 + Tim3 + CD8 + T cells ( l ) in day-32 tumor of the MC38-bearing wildtype or iTg mice ( k , l , n=6 per genotype). m , n , Flow cytometry ( m ) and qRT-PCR ( n ) analyses of PD1 and Tim3 expression level in tumor-infiltrating PD1 + Tim3 + CD8 + T cells of MC38-bearing (day 32) wildtype or iTg mice ( n , WT: n=2; NIK iTg : n=3) . o , Schematic of experimental</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0009.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Extended Data Fig. 1 NIK regulates T cell exhaustion and antitumor immunity a, genotyping PCR of R26Stop FL Map3k14 (Map3k14 Tg ), Map3k14 +/+ CreER, and R26Stop FL Map3k14 -CreER ( Map3k14 Tg CreER) mice, showing the PCR products of NIK-GFP in Map3k14 Tg allele and CreER. b, Immunoblot analysis of NIK expression in tamoxifen-treated Map3k14 +/+ CreER (WT) and Map3k14 Tg CreER (iTg) mice. c, Schematic of experimental design for producing B16F10 tumor-bearing NIK iTg and WT control mice. Each mouse was injected s.c. with 5 x 10 5 B16F10 cells (WT=9, iTg=7). d,e, Flow cytometric analysis of the frequency and absolute cell number of CD4 and CD8 T cells in the tumor (d) or draining lymph node (e) of day 18 B16F10 tumor-implanted NIK-iTg and WT mice ( d , WT: n=4; iTg: n=5; e , n=6 per genotype). f,g, Flow cytometric analysis of the frequency and absolute number of CD44 + CXCR3 + CD8 effector T cells in the draining lymph node ( f ) or tumor ( g ) of day 18 B16F10 tumor-implanted NIK-iTg and wildtype mice ( f , n=6 per genotype; g, n=4 per genotype). h,i, Flow cytometric analysis of the frequency and absolute number of PD1 + Tim3 + CD8 + T cells ( h ) or IFNgamma-producing PD1 + Tim3 + CD8 T cells ( i ) in the tumor of day 18 B16F10-implanted NIK iTg and wildtype control mice (h,i, n=4 per genotype). Data are representative of three independent experiments. Summary data are shown as mean +- s.e.m. with P values determined by two-tailed Student's t test.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14873_nihms-1642142-f0006.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 6. HK2 deletion blocks the autoimmune phenotype of NIK tTg mice. a, Body weight of 36-day old wildtype (WT), NIK tTg (tTg), and NIK tTg Hk tKO (tTg-tKO) littermate mice (WT: n=5, tTg: n=8, tTg-tKO: n=7) . b , Image of inguinal lymph nodes and thymi of four pairs of mice with the indicated genotypes. c , H&E staining of colon and lung sections from moribund NIK tTg , NIK tTg Hk tKO and age-matched littermate wildtype control mice were assessed for leukocyte infiltrates by hematoxylin-eosin stain. Scale bars: 100 mum. (n=3 in each group). d-g , Flow cytometric analysis of the frequency and absolute cell number of double-negative (DN), double-positive (DP), CD8 + single-positive (SP), and CD4 + SP thymocytes ( d ), thymic CD25 + foxp3 + T reg cells ( e ), lymph node CD25 + foxp3 + T reg cells ( f ), and lymph node CD44 - foxp3 + T reg cells ( g ) in NIK tTg , NIK tTg Hk tKO or wildtype mice ( e-f , NIK iTg : n=6, NIK tTg Hk tKO : n=4, wildtype: n=5). Data are representative of two ( a-c , e-g ) or three ( d ) independent experiments. Summary data are shown as mean +- s.e.m. with P values determined by two-tailed Student's t test ( a , d-g ) .</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15146_cells-09-02669-g002.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 2 Stemness markers of monolayers and spheroids from RT112 and 5637 cells. ( a - c ) Median fluorescence intensity of Aldefluor TM ( a ), CD44 ( b ) and CD133 ( c ) by flow cytometry analysis on RT112 and 5637 cells grown as monolayers. Results are the mean of two ( a ) and three ( b , c ) experimental replicates. Statistical test: t -test, * for p < 0.05. ( d ) Representative images from confocal immunofluorescence (IF) microscopy of RT112 and 5637 cells using SOX2 Antibody (red) and Hoechst 33342 (blue) for nuclei. Cells were grown as monolayer or spheroids on different (Tissue culture-treated, Not-treated or Cell repellent) supports, before being seeded in adherent condition on chamber slides for IF.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15136_13287_2020_2047_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Cell type-dependent levels of 5-methylcytosine and 5-hydroxymethylcytosine. a Representative fluorescent micrographs for canine fetal fibroblasts (cFFs) stained with phycoerythin (PE)-conjugated antibodies against CD44 and CD90/THY1. Scale bar unit length is 50 mum. b Overlay histograms showing cFFs stained with PE-conjugated antibodies (red) or isotype control antibodies (black). Fold difference in c 5-methylcytosine and d 5-hydroxymethylcyctosine levels in canine adult fibroblast (cAF), canine fetal fibroblast (cFF), canine partially reprogrammed (cPR), and canine embryonic stem cells (cESCs). Data are presented as mean +- standard error, n = 4. Relative transcript abundance for e TET1, f TET2, and g TET3 in steady-state cultures of cAF and cFF. Data are presented as mean +- standard error, n = 3. Means annotated with different letters are considered significantly different by one-way analysis of variance and Tukey's honestly squared difference test, P < 0.05</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19120_41419_2020_3219_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 3 EZH2 deficiency in DCs inhibited the CD4 + T-cell response during bacteria-induced liver injury. Ezh2 D-/- mice and WT mice were injected intravenously with P.ac suspended in PBS. The peripheral blood, liver, or spleen were isolated from naive, Ezh2 D-/- mice and WT mice on day 7. Statistical analyses of the numbers of A MNCs isolated from livers and spleens and B the CD4 + T-cell percentage of MNCs are shown. C The levels of CXCR3 and CCR7 expressed on CD4 + T cells were analyzed by flow cytometry. D The levels of CD44 and CD62L on CD4 + T cells were analyzed by flow cytometry. E The levels of serum IFN-gamma, IL-5, and IL-17 were measured by enzyme-linked immunosorbent assay ( n = 8 mice per group). F The production of the inflammatory cytokine IFN-gamma by CD4 + T cells was assessed by intracellular staining and analyzed by flow cytometry. Representative dot plots are shown. G MNCs isolated from livers and spleens were stained for CD4 and Foxp3 and analyzed by flow cytometry. Data are shown as the mean +- SEM of three independent experiments. * P < 0.05.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14883_gr2.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 2 NK Cells Contribute to Both Innate and Adaptive Immune Control of Ptgs -/- Tumors (A) Growth profile of Ptgs +/+ and Ptgs -/- melanoma cells implanted into Rag1 -/- or wild-type mice untreated or depleted of NK, CD4 + , and/or CD8 + cells. (B and C) Frequency of CD8 + T cells (B); representative plots and frequency of CD8 + CD44 + , CD8 + IFNgamma + , and CD4 + IFNgamma + T cells (C) gated on live, CD45 + , CD3epsilon + cells in Ptgs +/+ and Ptgs -/- untreated or NK cell-depleted wild-type mice analyzed 7 days post-implantation. (D) Individual growth profiles of Ptgs -/- melanoma cells in wild-type mice depleted of NK cells from the day before or a week after cancer cell implantation. (E) Growth profile of Ptgs +/+ and Ptgs -/- cells in wild-type mice or Ptgs +/+ cells in GPP mice. (F) Tumor weight, NK cell frequency, and number per g of tumor analyzed 4 days after implantation of Ptgs +/+ and Ptgs -/- cells in wild-type or Ptgs +/+ cells in GPP mice. (G) Growth profile of Ptgs +/+ and Ptgs -/- melanoma cells in wild-type or Ptgs +/+ melanoma cells in Ptger2 -/- or Gzmb-Cre Ptger4 floxed/floxed mice. Data are expressed as mean +- SEM, one-way (B-C and F) or two-way ANOVA (A).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15134_elife-56934-fig3.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 3. RNAseq of WNK1-deficient thymocytes reveals significant changes in five distinct processes. ( A ) Thymi were harvested from Wnk1 fl/+ Rag1 -/- CD2-Cre and Wnk1 fl/fl Rag1 -/- CD2-Cre mice that were either untreated (0 hr) or had been injected with anti-CD3epsilon antibody 3, 24 or 48 hr earlier. DN3+DN4 thymocytes were sorted, RNA purified and analyzed by RNAseq, results of which are shown in C-E. ( B ) Flow cytometric analysis of DN thymocytes from the experiment described in A. Gates indicate cells (Thy1.2 + , CD44 - ) that were sorted for further RNAseq analysis. ( C ) Principal component analysis using expression of all normalized genes for all samples from the experiment described in A. ( D ) Log 2 fold changes and total number of statistically significant differentially expressed genes (DEGs) in samples from Wnk1 fl/fl Rag1 -/- CD2-Cre (KO) mice compared to Wnk1 fl/+ Rag1 -/- CD2-Cre (HET) mice at each time point ( Supplementary files 2 , 3 ). ( E ) Metacore process analysis of DEGs. Selected processes and their P -values are shown at each time point; graph on left shows the lowest P -value for each process from any of the four time points. Red bars indicate time point with the lowest P -values for each process (Minimal). Ratios indicate the number of DEGs at each time point over the number of all genes in the indicated processes. Significance calculated by Wald's test ( D ) and Hypergeometric test ( E ). Sample sizes: three Wnk1 fl/+ Rag1 -/- CD2-Cre and four</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15134_elife-56934-fig2.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 2. WNK1 is required for thymocytes to develop past the pre-TCR checkpoint. ( A ) Left: flow cytometric analysis of Thy1.2 + Lineage - thymocytes separated by expression of CD44 and CD25, and then DN3 (CD44 - CD25 + ) cells separated into DN3a (small, FSC low CD28 - ) and DN3b (large, FSC high CD28 + ) cells. Right: Mean +- SEM cell numbers in DN subsets. ( B ) Left: Flow cytometric analysis of thymocytes from Wnk1 fl/+ CD2-Cre and Wnk1 fl/fl CD2-Cre mice showing intracellular TCRbeta levels in DN2+DN3 and DN4 subsets. Numbers indicate the percentage of TCRbeta + cells. Right: Mean +- SEM percentage of DN2+DN3 and DN4 cells that are intracellular TCRbeta + . ( C ) Mean +- SEM of CD3epsilon or pre-Talpha surface levels measured as mean fluorescence intensity (MFI) in flow cytometry of DN2+DN3 and DN4 thymocytes from Wnk1 fl/+ CD2-Cre and Wnk1 fl/fl CD2-Cre mice. ( D ) Left: flow cytometric analysis of CD4 and CD8 levels on thymocytes from Wnk1 fl/+ Rag1 -/- CD2-Cre and Wnk1 fl/fl Rag1 -/- CD2-Cre mice harvested 4 d after intraperitoneal injection with PBS or anti-CD3epsilon antibody. Gate indicates DP thymocytes and number shows percentage of cells in the gate. Right: mean +- SEM number of DP thymocytes defined using the gates on the left. *0.01<p<0.05, and **p<0.01. Significance calculated by Mann-Whitney test. Sample sizes: six of each genotype ( A, B ), eight Wnk1 fl/+ CD2-Cre and ten Wnk1 fl/fl CD2-Cre mice ( C ), four Wnk1 fl/+ Rag1 -/- CD2-Cre and Wnk1 fl/fl Rag1 -</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15134_elife-56934-fig1.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1. Essential role for WNK1 in thymocyte development. ( A ) Flow cytometric analysis of thymocytes from Wnk1 fl/+ CD2-Cre and Wnk1 fl/fl CD2-Cre mice showing double negative (DN, Thy1.2 + Lineage - ) thymocytes subdivided into DN1 (CD44 + CD25 - ), DN2+DN3 (CD25 + ), and DN4 (CD44 - CD25 - ) subsets, immature single positive (ISP, CD4 - CD8 + TCRbeta - ), double positive (DP, CD4 + CD8 + ), CD4 + single positive (4SP, CD4 + CD8 - ), and CD8 + single positive (8SP, CD4 - CD8 + TCRbeta + ) thymocytes. Numbers show % of cells falling into each gate. ( B ) Mean +- SEM number of total thymocytes and of thymocytes at each developmental stage defined using the gates in A, as well as gammadelta thymocytes (CD4 - TCRgamma + ). ( C ) Mean +- SEM number of cells in each thymocyte population in Wnk1 fl/fl CD2-Cre animals normalized to Wnk1 fl/+ CD2-Cre controls (set to 100%). ( D ) Mean +- SEM Wnk1 mRNA levels in thymic subsets from Wnk1 fl/+ CD2-Cre and Wnk1 fl/fl CD2-Cre mice, normalized to Wnk1 fl/+ CD2-Cre controls (set to 100%) measured by Q-PCR from exon 1 to exon 2. CD44 levels were used to separate DN2 (CD44 + ) and DN3 (CD44 - ) thymocytes. ( E ) Flow cytometric analysis of Rag1 -/- radiation chimeras reconstituted with bone marrow from Wnk1 fl/+ RCE and Wnk1 fl/D368A RCE mice, treated with tamoxifen and analyzed 7 d later showing gating for thymocyte subsets as in A, with DN (Thy1.2 + Lineage - ) thymocytes pre-gated on CD4 - CD8 - cells. ( F ) Mean +- SEM number of cells</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15133_CTM2-10-e139-g001.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">FIGURE 1 Characterization of colorectal CSCs isolated from LoVo and HT29 cells. A, Flow cytometric sorting of CSCs using CD44 and EpCAM as markers. The percentage of parental LoVo and HT29 cells expressing both CD44 and EpCAM was approximately 15%, representing the proportion of CSCs. CSCs isolated from parental LoVo and HT29 cells (denoted as LoVo-CSCs and HT29-CSCs, respectively) exhibited high expression of both markers (>90%). Relative proliferation of (B) LoVo-CSCs and (C) HT29-CSCs was inhibited by ATL-1 at 200 muM for up to 72 h, compared to that of control (+PBS) CSCs. The protein expression of stemness markers OCT-4, SOX-9, and Nanog, relative to GAPDH, in (D) LoVo-CSCs and (E) HT29-CSCs was downregulated by ATL-1 at 200 muM after 48 h of culture, compared to that of control (+PBS) CSCs. Transwell assay of the (F) migration and (G) invasion of LoVo-CSCs demonstrated decreased cell counts in both cases when ATL-1 was administered at 200 muM, compared to those of control (+PBS) CSCs. H, The percentage of apoptotic LoVo-CSCs and HT29-CSCs was elevated in the presence of ATL-1 at 200 muM, compared to that of control (+PBS) CSCs. The data represent the mean +- SD of three independent technical replicates ( t -test); * P < .05; % P < .05 at 72 h</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15121_urn-x-wiley-20011326-media-ctm2139-ctm2139-fig-0001.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">1 FIGURE Characterization of colorectal CSCs isolated from LoVo and HT29 cells. A, Flow cytometric sorting of CSCs using CD44 and EpCAM as markers. The percentage of parental LoVo and HT29 cells expressing both CD44 and EpCAM was approximately 15%, representing the proportion of CSCs. CSCs isolated from parental LoVo and HT29 cells (denoted as LoVo-CSCs and HT29-CSCs, respectively) exhibited high expression of both markers (>90%). Relative proliferation of (B) LoVo-CSCs and (C) HT29-CSCs was inhibited by ATL-1 at 200 muM for up to 72 h, compared to that of control (+PBS) CSCs. The protein expression of stemness markers OCT-4, SOX-9, and Nanog, relative to GAPDH, in (D) LoVo-CSCs and (E) HT29-CSCs was downregulated by ATL-1 at 200 muM after 48 h of culture, compared to that of control (+PBS) CSCs. Transwell assay of the (F) migration and (G) invasion of LoVo-CSCs demonstrated decreased cell counts in both cases when ATL-1 was administered at 200 muM, compared to those of control (+PBS) CSCs. H, The percentage of apoptotic LoVo-CSCs and HT29-CSCs was elevated in the presence of ATL-1 at 200 muM, compared to that of control (+PBS) CSCs. The data represent the mean +- SD of three independent technical replicates ( t -test); * P < .05; % P < .05 at 72 h</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19118_cells-09-01707-g005.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 5 Comparative analysis of SCESM spheroids and multi-cellular tumor spheroids (MCTSs). ( a ) Graph representing SCESM spheroid and MCTS mean diameter increase. Spheroids were photographed on days 2, 4, and 7 and representative phase-contrast microscope images of SCESM spheroids and MCTSs on days 2, 4, and 7 are displayed under the graph. Mean values +- SE ( n >= 8) are presented. Scale bars correspond to 400 um; ( b - e ) Protein expression of four different stem markers was assessed in SCESM spheroids and MCTSs by flow cytometry. Normalized fluorescence intensities of selected proteins are presented and corresponding flow cytometry visible light and fluorescent photos are attached ( n >= 5, N >= 2000); (b) CD44 protein expression; ( c ) CD73 protein expression; ( d ) CD90 protein expression; ( e ) CD133 protein expression; ( f ) OCT4 and tubulin protein expressions were assessed in SCESM spheroids and MCTSs by Western blot analysis. Western blot membrane photo showing OCT4 and tubulin and graph depicting normalized OCT4 protein expression analysis from Western blots (using Image Lab software) are presented ( n >= 3); ( g - i ) Relative gene expression of three additional stem markers assessed in 7-day-old MCTSs and SCESM spheroids; Normalized mean values +- SE ( n >= 5) are presented; ( g ) Relative gene expression of ALDH1A1 ; ( h ) Relative gene expression of NANOG ; ( i ) Relative gene expression of SOX2 . (* p < 0.05, **** p < 0.0001 vs. control (MCTS)). B: blank;</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19118_cells-09-01707-g004.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 4 Protein expression of stem markers. The protein expression of five different stem markers was assessed in the FaDu adherent cell line and 7-day-old SCESM spheroids by Western blot and flow cytometry. ( a - d ) Protein expression analyzed by flow cytometry. Normalized fluorescence intensities of selected proteins are presented, and corresponding flow cytometry visible light and fluorescent photos are attached. Normalized mean values +- SE ( n >= 5, N >= 2000) are presented (**** p < 0.0001 vs. control (adh)); ( a ) CD44 protein expression; ( b ) CD73 protein expression; ( c ) CD90 protein expression; ( d ) CD133 protein expression; ( e ) OCT4 and tubulin protein expression analyzed by Western blot. Western blot membrane photos showing OCT4 and tubulin and a graph depicting normalized OCT4 protein expression analysis from Western blots are presented. Bars represent normalized mean values +- SE ( n >= 3). B: blank; adh: adherent cell line; S: SCESM.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15132_13578_2020_428_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 1 SHP1 deficiency had no effect on the cell morphology, proliferation rate or surface markers. a Phase-contrast images of MSCs derived from bone marrow of WT and me v /me v mice. Scale bar: 50 mum. b The same number of WT and me v /me v MSCs were coated into the 6 well plates, the number were calculated every day until the sixth day and the proliferation rate was monitored. c After isolation from bone marrow and culture for an equal number of passages, me v /me v and WT MSCs were harvested and analyzed for the indicated markers by immunofluorescence staining and flow cytometry. The experiments were repeated at least three times. Error bars represent +- SEM (n = 3), ns, not significant</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15063_ijms-21-03675-g001.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1 Fluorescence-activated cell sorting (FACS) analyses of mesenchymal stem cell MSC)-conjugated control isotype IgG or antibodies against indicated cell-surface proteins. MSCs were negative for CD11b, CD34, and CD45 ( A ) and positive for CD29 and CD44 ( B ).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15144_cancers-12-01325-g003.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 3 CD44 deletion in breast cancer cell lines decreases expression of genes involved in cellular adhesion and cytokine activity. ( A ) CD44 KO was confirmed via Western blot and compared to the loading control beta-tubulin via densitometry. CD44 KO indicates that cells received gRNA targeting exons 1 and 5 of CD44. CD44 WT (CD29+/CD44+) and CD44 KO (CD29+/CD44-) cells were sorted and expanded in culture. ( B ) Venn diagram illustrating RNA sequencing results (submitted in triplicate). A total of 1530 and 320 genes were impacted by CD44 KO in the Hs578T cells and MDA-MB-231 cells, respectively. When comparing each of these data sets, 40 genes were differentially expressed in both Hs578T and MDA-MB-231 cells upon deletion of CD44. ( C ) Heat map demonstrating log fold change of differential gene expression in CD44 WT relative to CD44 KO Hs578T and MDA-MB-231 cells. ( D ) Gene ontology analysis identifying gene sets enriched in CD44 WT relative to CD44 KO Hs578T and MDA-MB-231 cells. Dot size represents the number of genes enriched within that pathway, while color represents an adjusted p -value.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9896_urn-x-wiley-07360266-media-jor24749-jor24749-fig-0007.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">7 Figure Fracture callus TSP2 positive cells express a MSC immunophenotype. Transverse femoral fractures were induced in TSP2-GFP reporter mice. Calluses from six mice were harvested 7 days post-fracture, pooled, and digested in trypsin, collagenase A, and hyaluronidase. Cells were labeled with anti-mouse directly conjugated MSC antibodies (CD44, CD105, CD45, and Sca-1) and DAPI before flow cytometry. A, Cells were gated by size and granularity using an SSC-A/FSC-A color density plot. Single cells were sub-gated by FSC-W/FSC-A and dead (DAPI+) cells were discriminated by sub-gating on a DAPI-A/SSC-A. B, Included cells were gated by GFP-A as either T2GFP-neg (red) or T2GFP-pos (green). C, Representative histograms of cell surface markers in T2GFP-pos cells. D, Representative histograms of cell surface markers in T2GFP-neg cells. Histograms were gated for positive selection of CD44, CD105, and Sca-1 and negative selection of CD45 to match the known MSC immunophenotype of CD44+/CD105+/CD45-/Sca-1+. Flow cytometry was repeated two times with an n = 2 per experiment. MSC, mesenchymal progenitor cells; TSP2, thrombospondin-2 [Color figure can be viewed at wileyonlinelibrary.com ]</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12759_fcell-08-00263-g001.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">FIGURE 1 Characterization of young and aged MSCs and exosomes. (A) Surface marker profiling of young-MSCs and aged-MSCs. (B) SA-beta-Gal staining showed that senescence increased significantly in aged MSCs. (C) Representative immunoblot images and quantitative analysis of p21, p53, and p16 protein level in young and aged-MSCs. ( n = 3). (D) Quantitation of cell cycle phases by propidium iodide staining. ( n = 3). (E) The CCK-8 assay showed that aged MSCs grew more slowly than young MSCs. ( n = 6). (F) Young and aged exosomes were observed using TEM. (G) The exosome surface markers were analyzed by Western blot. (H) Nanoparticle tracking analysis was used to analyze the particle size and concentration of Young-Exo and Aged-Exo. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; NS, not significant.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12843_fmicb-11-00821-g004.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">FIGURE 4 Changes in cellular sub-populations in differentiating MPIEs. (A) CD326 (Epcam) versus CD44 expression in cells harvested at different time points. (B) Transcriptional changes of the major cell marker genes in 3 days of differentiation detected by RT-qPCR. The transcription levels were normalized to that of GAPDH and the relative fold changes were calculated using the 2 -DeltaDeltaCT . Each bar indicated means +- standard deviations for three independent trials. The abbreviations on the map are leucine-rich-repeat-containing G-protein-coupled receptor 5 ( Lgr5 ), B cell-specific moloney murine leukemia virus integration site 1 ( Bmi1 ), Ki-67 ( Ki67 ), chromogranin A ( ChgA ), trefoil factor 3 ( TFF3 ), lysozyme ( Lyz ) and fatty acid-binding protein 1 ( L-Fabp ).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12698_ijms-21-02722-g004.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 4 obASCs promote a cancer stem-like phenotype through leptin. ( A ) Transwell co-culture with shCtrl obASCs upregulates NOTCH1, NOTCH3, DELTA1, and JAGGED2 in ER + BCCs. ( B ) BCCs have increased ability to form mammospheres after co-culture with shCtrl obASCs followed by 2 Gy radiation compared to non-co-cultured cells or cells co-cultured with shLep obASCs. ( C ) Flow cytometric analysis of the breast cancer stem cell markers CD44 + CD24 - was evaluated for BCCs after transwell co-culture with shCtrl obASCs or shLep obASCs. Values reported are the mean of three independent experiments each performed in triplicate. Bars, +- SEM. * p < 0.05, ** p < 0.01, *** p < 0.001.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19114_MMR-21-06-2405-g00.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1. Immunophenotyping results of isolated and cultured bone marrow-derived mesenchymal stem cells. Surface markers by flow cytometry for (A) CD44, (B) CD71 and (C) CD34. CD, cluster of differentiation.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19116_MMR-22-01-0286-g02.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 3. Expression of ALDH1, CD133 and CD44 prior to and following induction of differentiation in SP cells. SP or non-SP cells were incubated with anti-ALDH1, anti-CD133 and anti-CD44 antibodies together, and subjected to flow cytometry analysis. (A) Percentage of ALDH1 + , CD133 + or CD44 + cells in non-SP and SP cells prior to (day 0) and following differentiation (day 14). During flow cytometry analysis, Left, cells were analyzed for the expression of ALDH1 and CD133; Middle, cells were analyzed for the expression of ALDH1 and CD44; Right, cells were analyzed for the expression of CD133 and CD44. All these were conducted in the same population of SP or non-SP cells. (B) Percentage of only ALDH1 + cells in the same population of non-SP and SP cells in A prior to (day 0) and following differentiation (day 14). (C) Percentage of ALDH1 + cells in non-SP and SP cells prior to (day 0) and following differentiation (day 14) after three independent experiments. **P<0.01. ALDH1, aldehyde dehydrogenase-1; CD44, CD44 antigen; CD133, CD133 antigen; PE, phycoerythrin; APC, allophycocyanin; SSC, side scatter; SP, side population.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12842_41419_2020_2435_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 2 CCL5 promotes the invasion and the PCSCs subpopulation of prostate cancer cells in vitro. a , b CCL5 (2.5-40 ng/ml) had no obvious influences on the proliferation and colony formation capacities of the prostate cancer cell lines DU145 and PC3. c CCL5 addition (20-40 ng/ml) significantly promoted the migration and invasion of DU145 and PC3 cells. Scale bars represent 200 mum for wound healing assay images and 50 mum for transwell assay images. d Western blotting assay revealed that CCL5 (5-40 ng/ml) could promote EMT and metastasis of both DU145 and PC3 cells. e CCL5 treatment (20-40 ng/ml) significantly increased not only the number but also the size of mammospheres formed by prostate cancer cells. Scale bar, 100 mum. f , g CCL5 treatment (20-40 ng/ml) significantly elevated the CD44 + /CD133 + subpopulation and the ALDH + subpopulation in DU145 and PC3 cells, indicating that CCL5 could promote the self-renewal of PCSCs. All values are presented as the mean +- SD. n = 3, * p < 0.05, ** p < 0.01.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19108_MMR-21-05-2085-g00.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1. Identification and characteristics of hPDLSCs. Morphological characterization of hPDLSCs in (A) primary culture and (B) culture at passage 3. A periodontal membrane fragment is present and shown in A. Flow cytometry analysis of surface markers expressed on hPDLSCs, showing that they were positive for (D) 0CD44, (F) CD90 and (G) CD105, and negative for (C) CD34 and (E) CD45. (H) Following 3 weeks of culture in osteogenic induction medium, the cells were stained with alizarin red. Mineralized nodules are shown. (I) Following 3 weeks of culture in adipogenic induction medium, the cells were stained with Oil Red O. Lipid globules are shown (black arrow). hPDLSCs, human periodontal ligament stem cells; PE, phycoerythrin.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_7826_ijms-21-00404-g001.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1 Characterization of BCSC5 in vitro and in vivo. ( A ) Representative pictures of BCSC5 cultured in 3D and 2D conditions, scale bar 100 mum. ( B ) Sphere-forming capacity of BCSC5 cells in an anchorage-independent growth assay ( n = 3). Data represent means + SEM. ( C , D ) Expression patterns of CD24 and CD44 ( C ) as well as EpCAM and CD49f ( D ) in BCSC5 cells analyzed by flow cytometry. ( E ) Tumor formation in limiting dilution xenografts of BCSC5. ( F ) Representative growth curves for limiting dilution assay of BCSC5 xenografts in immunocompromised NOD/SCID mice. ( G ) Immunohistochemical (IHC) analysis of ER, PR, and HER2 on sections of the BCSC5 xenograft tumors, scale bar 100 mum.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_7523_SCI2019-8035076.001.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1 Growth characteristics of USCs. (a) The morphology of USCs by passage and differentiation. Single, small, compact rice grain-like cells were observed on the third day after initial seeding, and they formed a colony on the seventh day. The cells were considered to be at P0 when the confluence reached 70-80% and were passaged to the next generation. The USCs maintained the rice grain-like morphology after several passages, and USCs from the P3 generation were induced to differentiate into SMCs and UCs. The cells showed an elongated and spindle-shaped morphology after SMC differentiation and a cobblestone-shaped morphology after UC differentiation. Scale bar: 50 mu m, 100 mu m, and 200 mu m. (b) The growth curve of USCs from the P3 generation. (c) Detection of surface markers in USCs using flow cytometry. USCs did not express hematopoietic stem cell markers (CD31: 0.45%, CD34: 0.28%) but expressed MSC markers (CD44: 100%, CD73: 97.1%, and CD105: 96.3%) and pericyte markers (CD146: 95.7%). (d) Detection of surface markers in USCs using IF. USCs did not express hematopoietic stem cell markers (CD31, CD34, and CD45) but did express MSC markers (CD44 and CD133), the ESC marker SSEA4, and pericyte markers (CD146, PDGFRB, and NG2). NC: negative control; PDGFRB: platelet-derived growth factor beta-receptor; NG2: neural/glial antigen 2. Scale bar: 25 mu m.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15108_cancers-12-00029-g001.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1 Identification of ADSCs. ( A ) ADSCs were isolated from the adipose tissue of breast tumors. After two to three passages, the expressions of ADSCs markers (CD90FITC, CD105PE, and CD44FITC) and the lack of CD34PE and CD45FITC were confirmed by flow cytometry. ( B ) The differentiation ability of ADSCs was tested by adipogenesis, osteogenesis, and chondrogenesis.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0008.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0007.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0005.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0003.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8294_nihms-1545180-f0002.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_6043_1951f01.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19113_gr6.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig. 6 PSMD14 depletion reduces BMP6-mediated colorectal cancer stemness. (a, b) FACS analysis of CD133 + /CD44 + cells in PSMD14 - or ALK2 -depleted HCT116 cells, which were treated with 100 ng/ml BMP6 for 48 h. The proportion of the CD133 + /CD44 + fraction was described with the density plots (a) and a bar graph (b) . shGFP-expressing HCT116 cells were used as a control. (c) Sphere forming assay of PSMD14 - or ALK2 - depleted HCT116 cells. Spheres with a diameter above 50 mum were counted and described in a bar graph. Scale bars, 50 mum. (d) PSMD14 - or ALK2 -depleted HCT116 cells were treated with BMP6. Expression of pluripotent transcription factors were analyzed by immunoblotting with the indicated antibodies. siCON-expressing HCT116 cells were used as a control. (e, h) 2 x 10 4 cells of PSMD14 -, ALK2 -, ABCA7 - or ABCC4 -depleted HCT116 were respectively treated with 20 muM oxaliplatin and 30 muM DAPT and their viabilities were measured at 6 h. shGFP-expressing HCT116 cells were used as a control. (f, g) PSMD14 - or ALK2 -depleted HCT116 cells were treated with BMP6 for 6 h. Expressions of ABCA7 and ABCC4 were measured by quantitative RT-PCR. The data were statistically analyzed by two-way ANOVA followed by Bonferroni's multiple comparison test ( n = 3, *** P < 0.001 compared to the indicated controls. ns; not significant). The bars represent the mean +- s .d. The images in this figure are representative of three independent experiments. In (b), (c), (e) and (h) were</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_5963_ppat.1007856.g009.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Fig 9 The infection with IIIDelta rop16 :: ROP16 III parasites restores type III-like CNS response with higher CNS macrophages/microglia and T cells. Mice were inoculated with type III, IIIDelta rop16 , or IIIDelta rop16 : ROP16 parasites. Brains were harvested at 21 dpi and analyzed as in Figs 1(A), 1(B) , 2(C), 2(D) or 3(E) and 3(F) . A. Quantification of the number of Iba-1 + cells (macrophages/microglia). B. Quantification of the number of CD3 + T cells. Bars, mean +- SEM. N = 12 fields of view/section, 3 sections/mouse, 4-5 mice/infected group. For each mouse, the number of cells/section was averaged to create a single point. C. Quantification of CNS Toxoplasma burden by qPCR for the Toxoplasma -specific B1 gene. D. Quantification of Toxoplasma cyst burden in brain sections stained with DBA. E. CNS mononuclear cells evaluated for the presence of M2 macrophages. F. CNS mononuclear cells evaluated for the presence of M1-like macrophages. Bars, mean +- SEM. N = 12 fields of view/section, 3 sections/mouse, 4-5 mice/infected group. *p<0.05, **p<0.01, two-way ANOVA with Fisher's protected LSD. Data representative of 2 independent experiments using a single IIIDelta rop16 clone and IIIDelta rop16 : ROP16 clone.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_6036_IJO-55-06-1296-g00.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1 Proportion of CD44 + /CD133 + cancer stem cells in ovarian cancer tissues of each patient by flow cytometry.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9897_nihms-1549105-f0004.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9897_nihms-1549105-f0003.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12841_MOL2-14-139-g003.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 3 Knocking down of PIK3CA failed to reverse EMT and reduce CSC population. (A) Western blotting of p110alpha, E-cadherin and vimentin in CU110-2 cells stably transfected with lentiviral-mediated shRNA ( shPIK3CA ) or a scrambled control ( SCR ). GAPDH was used as a loading control. Quantitation of western blots is shown in right. (B) HNSCC Sphe-forming assay of CU110 cells stably transfected either shPIK3CA or SCR lentivirus. Sphes with diameter >= 30 mum were counted; quantification of Sphe is shown on the right, n = 3; error bars indicate SD. * P < 0.05 (two-tailed Student t- test). Scale bar: 100 u m . (C) FACS analysis of CD44 in CU110 cells stably transfected either shPIK3CA or SCR lentivirus. Quantification of CD44 population is shown on top. n = 3; error bars indicate SD. (D) FACS analysis of CD24 in CU110 cells stably transfected either shPIK3CA or SCR lentivirus. Quantification of CD24 population is shown on top. n = 3; error bars indicate SD. (E) SP fraction using Hoechst dye-effluxing analysis in CU110 cells stably transfected either shPIK3CA or SCR lentivirus. Quantification of SP fraction is shown on top. n = 3; error bars indicate SD. * P < 0.05 (two-tailed Student t- test). (F) HNSCC Sphe-forming assay of Fadu or UMSCC47 cell lines stably transfected with either shPIK3CA or SCR . The quantification is shown on the left. Error bars indicate SD. Scale bar: 100 u m.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12841_MOL2-14-139-g006.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 6 Targeting multiple RTK pathways effectively eliminates CSC populations with inhibiting Ephs, TRKs, and c-Kit the most prominent. (A) FACS analysis of CD44 (left) or ALDH (right) in CU110 cells treated with LDN211904. Error bars indicate SD. n = 3. * P < 0.05 (two-tailed Student t- test). (B) FACS analysis of ALDH in CU110 cells treated with GNF5837. Error bars indicate SD. n = 3. * P < 0.05 (two-tailed Student t- test). (C) FACS analysis of CD44 (left) or SP fraction (right) in CU110 cells treated with imatinib. Error bars indicate SD. n = 3. * P < 0.05 (two-tailed Student t- test). (D) Effect of pharmaceutical inhibitors (as indicated in the figure) on reducing CSC population in human HNSCC cell lines: Fadu and UMSCC47, using Sphe-forming assay. The quantification is shown on right. n = 3; error bars indicate SD. * P < 0.05 (two-tailed Student t- test). Scale bar: 100 u m.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_5950_MMR-20-04-3123-g00.jpg?time=20240507?time=20240507" alt="CD44 Antibody in Flow Cytometry (Flow)" title="CD44 Antibody (17-0441-82) in Flow"> <figcaption itemprop="caption">Figure 1. Characterization of PDLSCs. (A) PDL cell clusters exhibited radiating or whirlpool-like morphology. The central structure in this image is a fragment of PDL tissue. Scale bar, 200 mum (B) CD146 + PDLSCs were small, round, fusiform and triangular. Scale bar, 100 mum. (C) PDLSCs were positive for the stem cell markers CD44, CD90 and CD105, but negative for CD34 and CD45, as detected by flow cytometry. PDL, periodontal ligament; PDLSCs, PDL stem cells.</figcaption> </figure> </div> </div> </noscript> <div id="tf-related-products-container-new"></div> <div class="product-details"> <div class="container"> <div class="row"> <div class="large-span-12 medium-span-12 small-span-12"> <h2 class="pdp-sub-heading product_details_heading">Product Details</h2></div> <div class="hidden-sku"> <h2>17-0441-82</h2> </div> <div class="product-detail-section tested-app-section new-tbl-design product-detail-section table-spec"> <div class="product-container-head"> <div class="product-item"> Applications </div> <div class="product-item dilution-lbl-head "> Tested Dilution </div> <div class="product-item published-applications"> Publications </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (Frozen) (IHC (F))</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHCF-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunocytochemistry (ICC/IF)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#ICCIF-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 4 publications</span> <span class="mobile-view">4 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Flow Cytometry (Flow)</h2></div> <div class="product-item "> <span class="dilution-lbl">0.06 µg/test</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Flow-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 293 publications</span> <span class="mobile-view">293 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Miscellaneous PubMed (Misc)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Misc-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> </div> <div class="product-detail-section tested-app-section new-tbl-design product-specific-section table-spec"> <div class="product-container-head"> <div class="product-item">Product Specifications</div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Species Reactivity</h2> </div> <div class="product-item left-flex-cls"> <span title="Homo sapiens">Human,</span> <span title="Mus musculus">Mouse</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Published species</h2> </div> <div class="product-item left-flex-cls"> <span>Bacteria,</span> <span>Dog,</span> <span>Fruit fly,</span> <span>Human,</span> <span>Mouse,</span> <span>Non-human primate</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2> Host/Isotype</h2> </div> <div class="product-item left-flex-cls"> <span title="Rattus">Rat / IgG2b, kappa</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Recommended Isotype Control</h2> </div> <div class="product-item left-flex-cls"> <a href="//www.thermofisher.com/antibody/product/17-4031-82"> Rat IgG2b kappa Isotype Control (eB149/10H5), APC, eBioscience™</a> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Class</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Monoclonal </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Type</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Antibody </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Clone</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> IM7 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Conjugate</h2> </div> <div class="product-item left-flex-cls"> <a ng-if="$ctrl.checkConjugate('APC ') && '/us/en/home/life-science/cell-analysis/fluorophores/allophycocyanin.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye'.trim() != ''" href="/us/en/home/life-science/cell-analysis/fluorophores/allophycocyanin.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye" ng-attr-target="{{$ctrl.getRequestCustomLinkTarget()}}" class="conjugate-value">APC </a> <span ng-if="($ctrl.checkConjugate('APC ') && '/us/en/home/life-science/cell-analysis/fluorophores/allophycocyanin.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye'.trim() == '')" class="conjugate-value">APC </span> <span ng-if="!$ctrl.checkConjugate('APC ')" class="conjugate-value">APC </span> <div class="dropdown conjugate-dropdown"> <button class="btn-link conjugate-btn" type="button" data-toggle="dropdown"> View additional formats <span class="caret"></span> </button> <ul class="dropdown-menu dropdown-menu-fixed"> <li><a class="conjugate-color-padding" href="/antibody/product/14-0441-82"> Unconjugated <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/58-0441-82"> Alexa Fluor 532 <span class="conjugate-indicator" style="background-color:#B3FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/56-0441-82"> Alexa Fluor 700 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/47-0441-82"> APC-eFluor 780 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/13-0441-82"> Biotin <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/363-0441-82"> Brilliant UV 395 <span class="conjugate-indicator" style="background-color:#8000A1"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/364-0441-82"> Brilliant UV 496 <span class="conjugate-indicator" style="background-color:#00FFFF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/365-0441-82"> Brilliant UV 563 <span class="conjugate-indicator" style="background-color:#C3FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/366-0441-82"> Brilliant UV 615 <span class="conjugate-indicator" style="background-color:#FF8900"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/367-0441-82"> Brilliant UV 737 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/404-0441-82"> Brilliant Violet 421 <span class="conjugate-indicator" style="background-color:#5400FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/406-0441-82"> Brilliant Violet 605 <span class="conjugate-indicator" style="background-color:#FFAD00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/416-0441-82"> Brilliant Violet 650 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/407-0441-82"> Brilliant Violet 711 <span class="conjugate-indicator" style="background-color:#820000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/48-0441-82"> eFluor 450 <span class="conjugate-indicator" style="background-color:#0028FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/69-0441-82"> eFluor 506 <span class="conjugate-indicator" style="background-color:#00FF54"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/11-0441-82"> FITC <span class="conjugate-indicator" style="background-color:#1FFF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/16-0441-82"> Functional Grade <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M010T02B01-A"> NovaFluor Blue 510 <span class="conjugate-indicator" style="background-color:#00FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M010T02B06-A"> NovaFluor Blue 610-70S <span class="conjugate-indicator" style="background-color:#FF8900"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M010T02B08-A"> NovaFluor Blue 660-120S <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M010T03B09-A"> NovaFluor Blue 690 <span class="conjugate-indicator" style="background-color:#970000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M010T02R03-A"> NovaFluor Red 700 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M010T02R04-A"> NovaFluor Red 710 <span class="conjugate-indicator" style="background-color:#820000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M010T03R05-A"> NovaFluor Red 725 <span class="conjugate-indicator" style="background-color:#610000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M010T03R06-A"> NovaFluor Red 755 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M010T02Y01-A"> NovaFluor Yellow 570 <span class="conjugate-indicator" style="background-color:#E1FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M010T02Y03-A"> NovaFluor Yellow 610 <span class="conjugate-indicator" style="background-color:#FF8900"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M010T02Y04-A"> NovaFluor Yellow 660 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M010T03Y08-A"> NovaFluor Yellow 755 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/12-0441-82"> PE <span class="conjugate-indicator" style="background-color:#F0FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/15-0441-82"> PE-Cyanine5 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/25-0441-82"> PE-Cyanine7 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/61-0441-82"> PE-eFluor 610 <span class="conjugate-indicator" style="background-color:#FF9B00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/45-0441-82"> PerCP-Cyanine5.5 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/62-0441-82"> Super Bright 436 <span class="conjugate-indicator" style="background-color:#3D00FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/63-0441-82"> Super Bright 600 <span class="conjugate-indicator" style="background-color:#FFBE00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/64-0441-82"> Super Bright 645 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/67-0441-82"> Super Bright 702 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/78-0441-80"> Super Bright 780 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li class="drop-down-link-ctnr"> <a class="conjugate-dropdown-link" href="/us/en/home/global/forms/antibody-conjugates-custom-form.html" ng-attr-target="$ctrl.getRequestCustomLinkTarget()">Request custom conjugation <svg class="svg-icon external-link-icon" ng-if="$ctrl.showExternalLinkIcon()"> <use href="#external-link"></use> </svg> </a> </li> </ul> </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Excitation/Emission Max</h2> </div> <div class="product-item left-flex-cls"> <span>651/660 nm</span> <a target="_blank" class="spectra-view" href="/order/fluorescence-spectraviewer?SID=srch-svtool&UID=803ph75"> <span class="view-spectra"> View spectra</span> <span class="spectra-view-icon "><img src="/order/genome-database/assets/img/spectra.png" alt="spectra"/></span> </a> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Form</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Liquid </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Concentration</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.2 mg/mL </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Purification</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Affinity chromatography </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage buffer</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> PBS, pH 7.2 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Contains</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.09% sodium azide </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 4° C, store in dark, DO NOT FREEZE! </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Shipping conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Ambient (domestic); Wet ice (international) </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"><h2>RRID <span id="rrid-tooltip" class="rrid-tooltip-icon" ng-include="'/order/genome-database/webapp/assets/core/img/svg/mono_tooltip.svg'" data-toggle="tooltip" ng-click="$ctrl.showRridTooltip()" close-tooltip="$ctrl.closeRridTooltip()" title="Research Resource Identifiers (#RRID) are ID numbers assigned to help researchers cite key resources in the biomedical literature to improve transparency of research methods."> </span></h2> </div> <div class="product-item left-flex-cls">AB_469390</div> </div> </div> <div class="product-specific-details"> <div class="product-specific-details-tbl product-specific-add-border" > <div class="product-info-para"> <h4 class="product-info-para-heading"> Product Specific Information </h4> <p>Description: The IM7 monoclonal antibody reacts with all isoforms of mouse CD44 (Pgp-1). CD44 is expressed by hematopoietic and non-hematopoietic cells. Bone marrow myeloid cells and memory T cells highly express this antigen and peripheral B and T cells can upregulate the expression of CD44. CD44 functions as an adhesion molecule through its binding to hyaluronate, an extracellular matrix component.<br /><br />Applications Reported: The IM7 antibody has been reported for use in flow cytometric analysis.<br /><br />Applications Tested: The IM7 antibody has been tested by flow cytometric analysis of mouse bone marrow cells and splenocytes. This can be used at less than or equal to 0.06 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.<br /><br />Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.<br /><br />Filtration: 0.2 µm post-manufacturing filtered.</p> </div> <div class="product-info-para"> <h4 class="product-info-para-heading"> Target Information </h4> <p class="product-specific-target-info">CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.</p> </div> <p class="product-details-regulatoryStmt">For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.</p> </div> <div class="product-detail-panel-builder"> <tf-promo-ad ng-if="$ctrl.showPromoAd" show-promo-ad="$ctrl.showPromoAd"></tf-promo-ad> <div class="product-detail-video"> <div tf-video-player-new video-id="6206990159001" player-width="368" player-height="210"></div> <div class="panel-builder"> <h4 class="product-info-para-heading"> How to use the Panel Builder </h4> <p>Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.</p> </div> </div> </div> </div> </div> </div> </div> <div id="rootPdpDocLoader"></div> <div id="tf-related-products-container" ng-show="emptyRelatedProductsWidget === false" > <related-products-container ng-if="showRelatedProductsWidget === true" base-url="'/api/magellan/related-products-ui/widget/v2/'" product-type="'antibody'" product-sub-type="'primary'" product-id="'17-0441-82'" country-code="'sg'" iso-language="'en'" > </related-products-container> </div> <div class="tf-pdp-divider" ng-if="emptyRelatedProductsWidget === false" ></div> <div class="references reference-section-1" id="references-component-id"> <div id="references-section-id"> <reference-section ng-if="loadReferences" default-display-card-limit="3" reference-count="299" sub-type="'Antibody'" application-data='{"citationApplications":[{"applicationAbbreviation":"IHC (F)","citations":[{"title":"A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates.","summary":"17-0441-82 was used in Immunohistochemistry (Frozen) to identify developmental-specific secretory progenitors and a subtype of neuroendocrine cell related to human small cell lung cancer.","authors":"He P,Lim K,Sun D,Pett JP,Jeng Q,Polanski K,Dong Z,Bolt L,Richardson L,Mamanova L,Dabrowska M,Wilbrey-Clark A,Madissoon E,Tuong ZK,Dann E,Suo C,Goh I,Yoshida M,Nikolić MZ,Janes SM,He X,Barker RA,Teichmann SA,Marioni 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itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36493756"> <div itemprop="name">A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">He P,Lim K,Sun D,Pett JP,Jeng Q,Polanski K,Dong Z,Bolt L,Richardson L,Mamanova L,Dabrowska M,Wilbrey-Clark A,Madissoon E,Tuong ZK,Dann E,Suo C,Goh I,Yoshida M,Nikolić MZ,Janes SM,He X,Barker RA,Teichmann SA,Marioni JC,Meyer KB,Rawlins EL</div> <div itemprop="description">17-0441-82 was used in Immunohistochemistry (Frozen) to identify developmental-specific secretory progenitors and a subtype of neuroendocrine cell related to human small cell lung cancer.</div> <div itemprodp="datePublished">Thu Dec 08 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35417043"> <div itemprop="name">Epidermal growth factor 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KW,Scherl EJ,Longman RS</div> <div itemprop="description">17-0441-82 was used in Flow cytometry/Cell sorting to identify MNPs as metabolic sensors linking AIEC metabolism with intestinal inflammation and identify microbial metabolism as a potential therapeutic target in Crohn's disease treatment.</div> <div itemprodp="datePublished">Wed Apr 14 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33398181"> <div itemprop="name">NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33837287"> <div itemprop="name">Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Monserrat J,Morales Torres C,Richardson L,Wilson TS,Patel H,Domart MC,Horswell S,Song OR,Jiang M,Crawford M,Bui M,Dalal Y,Scaffidi P</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34403373"> <div itemprop="name">Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Chen Z,Lu T,Huang L,Wang Z,Yan Z,Guan Y,Hu W,Fan Z,Zhu P</div> <div itemprop="description">17-0441-82 was used in Flow Cytometry to identify a functional circular RNA, termed circRNA activating MAFF (cia-MAF), that is robustly expressed in liver cancer and liver Liver tumor-initiating cells.</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34473195"> <div itemprop="name">A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Rappe JCF,Finsterbusch K,Crotta S,Mack M,Priestnall SL,Wack A</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Nov 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34037669"> <div itemprop="name">Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 02 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34180951"> <div itemprop="name">Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Hosokawa H,Koizumi M,Masuhara K,Romero-Wolf M,Tanaka T,Nakayama T,Rothenberg EV</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 02 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33709544"> <div itemprop="name">Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination.</div> </a> <div itemprop="about">EMBO molecular medicine</div> <div itemprop="author">Müller K,Gibbins MP,Roberts M,Reyes-Sandoval A,Hill AVS,Draper SJ,Matuschewski K,Silvie O,Hafalla JCR</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 09 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33748126"> <div itemprop="name">Senescent T Cell Induces Brown Adipose Tissue "Whitening" <i>Via</i> Secreting IFN-γ.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Pan XX,Yao KL,Yang YF,Ge Q,Zhang R,Gao PJ,Ruan CC,Wu F</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Mar 23 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34336843"> <div itemprop="name"><i>Trichinella spiralis</i> Paramyosin Induces Colonic Regulatory T Cells to Mitigate Inflammatory Bowel Disease.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Hao C,Wang W,Zhan B,Wang Z,Huang J,Sun X,Zhu X</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Aug 03 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35047398"> <div itemprop="name">Downregulation of SLC27A6 by DNA Hypermethylation Promotes Proliferation but Suppresses Metastasis of Nasopharyngeal Carcinoma Through Modulating Lipid Metabolism.</div> </a> <div itemprop="about">Frontiers in oncology</div> <div itemprop="author">Zhong X,Yang Y,Li B,Liang P,Huang Y,Zheng Q,Wang Y,Xiao X,Mo Y,Zhang Z,Zhou X,Huang G,Zhao W</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 21 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32437051"> <div itemprop="name">Thrombospondin-2 spatiotemporal expression in skeletal fractures.</div> </a> <div itemprop="about">Journal of orthopaedic research : official publication of the Orthopaedic Research Society</div> <div itemprop="author">Zondervan RL,Jenkins DC,Reicha JD,Hankenson KD</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33912169"> <div itemprop="name">Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 20 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33705411"> <div itemprop="name">Prophylactic efficacy against Mycobacterium tuberculosis using ID93 and lipid-based adjuvant formulations in the mouse model.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Baldwin SL,Reese VA,Larsen SE,Beebe E,Guderian J,Orr MT,Fox CB,Reed SG,Coler RN</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Oct 13 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33880359"> <div itemprop="name"><i>In Vitro</i> Anti-cancer Activity of Adipose-Derived Mesenchymal Stem Cells Increased after Infection with Oncolytic Reovirus.</div> </a> <div itemprop="about">Advanced pharmaceutical bulletin</div> <div itemprop="author">Babaei A,Bannazadeh Baghi H,Nezhadi A,Jamalpoor Z</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34226515"> <div itemprop="name">Valproic acid stimulates myogenesis in pluripotent stem cell-derived mesodermal progenitors in a NOTCH-dependent manner.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Breuls N,Giarratana N,Yedigaryan L,Garrido GM,Carai P,Heymans S,Ranga A,Deroose C,Sampaolesi M</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 05 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33740991"> <div itemprop="name">miR-34a mimic or pre-mir-34a, which is the better option for cancer therapy? KatoIII as a model to study miRNA action in human gastric cancer cells.</div> </a> <div itemprop="about">Cancer cell international</div> <div itemprop="author">Jafari N,Abediankenari S,Hossein-Nataj H</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Mar 19 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34644563"> <div itemprop="name">PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8<sup>+</sup> T cells at the expense of central memory.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 12 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34638401"> <div itemprop="name">MiR-125b-5p Is Involved in Sorafenib Resistance through Ataxin-1-Mediated Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Hirao A,Sato Y,Tanaka H,Nishida K,Tomonari T,Hirata M,Bando M,Kida Y,Tanaka T,Kawaguchi T,Wada H,Taniguchi T,Okamoto K,Miyamoto H,Muguruma N,Tanahashi T,Takayama T</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 30 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34189432"> <div itemprop="name">Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">AbuEid M,McAllister DM,McOlash L,Harwig MC,Cheng G,Drouillard D,Boyle KA,Hardy M,Zielonka J,Johnson BD,Hill RB,Kalyanaraman B,Dwinell MB</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 25 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34887404"> <div itemprop="name">Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Dec 09 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33557007"> <div itemprop="name">Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Sávio-Silva C,Soinski-Sousa PE,Simplício-Filho A,Bastos RMC,Beyerstedt S,Rangel ÉB</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Feb 04 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34610317"> <div itemprop="name">Attenuation of apoptotic cell detection triggers thymic regeneration after damage.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Kinsella S,Evandy CA,Cooper K,Iovino L,deRoos PC,Hopwo KS,Granadier DW,Smith CW,Rafii S,Dudakov JA</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 05 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34693362"> <div itemprop="name">Protocols for isolation and characterization of mouse placental hemogenic endothelial cells.</div> </a> <div itemprop="about">STAR protocols</div> <div itemprop="author">Liang G,Huang B,Wang F,Liu F</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 17 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33933782"> <div itemprop="name">Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.</div> </a> <div itemprop="about">EBioMedicine</div> <div itemprop="author">Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat May 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34816102"> <div itemprop="name">CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Qadir AS,Guégan JP,Ginestier C,Chaibi A,Bessede A,Charafe-Jauffret E,Macario M,Lavoué V,Rouge TM,Law C,Vilker J,Wang H,Stroup E,Schipma MJ,Bridgeman B,Murmann AE,Ji Z,Legembre P,Peter ME</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Fri Nov 19 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34230478"> <div itemprop="name">3-hydroxyanthranic acid increases the sensitivity of hepatocellular carcinoma to sorafenib by decreasing tumor cell stemness.</div> </a> <div itemprop="about">Cell death discovery</div> <div itemprop="author">Gan G,Shi Z,Liu D,Zhang S,Zhu H,Wang Y,Mi J</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jul 06 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34230478"> <div itemprop="name">3-hydroxyanthranic acid increases the sensitivity of hepatocellular carcinoma to sorafenib by decreasing tumor cell stemness.</div> </a> <div itemprop="about">Cell death discovery</div> <div itemprop="author">Gan G,Shi Z,Liu D,Zhang S,Zhu H,Wang Y,Mi J</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jul 06 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34363355"> <div itemprop="name">A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.</div> </a> <div itemprop="about">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</div> <div itemprop="author">Yu S,Lu Y,Su A,Chen J,Li J,Zhou B,Liu X,Xia Q,Li Y,Li J,Huang M,Ye Y,Zhao Q,Jiang S,Yan X,Wang X,Di C,Pan J,Su S</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34487763"> <div itemprop="name">Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34593794"> <div itemprop="name">A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 30 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34911928"> <div itemprop="name">GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Yu H,Yang W,Huang J,Miao X,Wang B,Ren X,Gu Y,Wang Q,Ding X,Guo X,Qian F,Zhang Y,Xu H,Zheng L,Jin M</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Dec 16 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34721389"> <div itemprop="name">Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 11 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34721389"> <div itemprop="name">Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 11 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34850744"> <div itemprop="name">MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Tilstam PV,Schulte W,Holowka T,Kim BS,Nouws J,Sauler M,Piecychna M,Pantouris G,Lolis E,Leng L,Bernhagen J,Fingerle-Rowson G,Bucala R</div> <div itemprop="description">17-0441-82 was used in flow cytometry to study Mif-/- and Mif-2-/- mice to polymicrobial sepsis and observed a survival benefit with Mif but not Mif-2 deficiency.</div> <div itemprodp="datePublished">Wed Dec 01 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34910919"> <div itemprop="name">Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Li J,Xu B,He M,Zong X,Cunningham T,Sha C,Fan Y,Cross R,Hanna JH,Feng Y</div> <div itemprop="description">17-0441-82 was used in Flow cytometry/Cell sorting to investigate how Treg cells are mechanistically induced in vitro (iTreg) and stabilized via transcriptional regulation of Treg lineage-specifying factor Foxp3.</div> <div itemprodp="datePublished">Tue Dec 14 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34294718"> <div itemprop="name">Mitochondrial transcription factor A in RORγt<sup>+</sup> lymphocytes regulate small intestine homeostasis and metabolism.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Fu Z,Dean JW,Xiong L,Dougherty MW,Oliff KN,Chen ZE,Jobin C,Garrett TJ,Zhou L</div> <div itemprop="description">17-0441-82 was used in Flow Cytometry to show that IL-22, a cytokine produced by RORγt+ lymphocytes inhibits IL-13-induced tuft cell differentiation in vitro, and suppresses the tuft cell-type 2 immune circuit and small intestine lengthening in vivo, highlighting its key role in gut tissue remodeling.</div> <div itemprodp="datePublished">Thu Jul 22 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35008877"> <div itemprop="name">Depletion of Retinal Dopaminergic Activity in a Mouse Model of Rod Dysfunction Exacerbates Experimental Autoimmune Uveoretinitis: A Role for the Gateway Reflex.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Stofkova A,Zloh M,Andreanska D,Fiserova I,Kubovciak J,Hejda J,Kutilek P,Murakami M</div> <div itemprop="description">17-0441-82 was used in Flow cytometry/Cell sorting to hypothesize that rod photoreceptor dysfunction causes remodeling of retinal neural activity, which influences the blood-retinal barrier and the development of retinal inflammation.</div> <div itemprodp="datePublished">Fri Dec 31 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34504547"> <div itemprop="name">Knockdown of ALDH1A3 reduces breast cancer stem cell marker CD44 via the miR-7-TGFBR2-Smad3-CD44 regulatory axis.</div> </a> <div itemprop="about">Experimental and therapeutic medicine</div> <div itemprop="author">Pan M,Li M,Guo M,Zhou H,Xu H,Zhao F,Mei F,Xue R,Dou J</div> <div itemprop="description">17-0441-82 was used in Flow cytometry/Cell sorting to demonstrate that the ALDH1A3-miR-7-TGFBR2-Smad3-CD44 regulatory axis was highly efficient in the inhibition of CD44 expression in BCSCs, and that the regulatory expression of ALDH1A3 and miR-7 may provide a strategy in the therapy of breast cancer.</div> <div itemprodp="datePublished">Fri Oct 01 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33665631"> <div itemprop="name">Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.</div> </a> <div itemprop="about">STAR protocols</div> <div itemprop="author">Skordos I,Demeyer A,Beyaert R</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Mar 19 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33220234"> <div itemprop="name">Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 15 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32454024"> <div itemprop="name">Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Soni C,Perez OA,Voss WN,Pucella JN,Serpas L,Mehl J,Ching KL,Goike J,Georgiou G,Ippolito GC,Sisirak V,Reizis B</div> <div itemprop="description">17-0441-82 was used in Flow Cytometry to establish extrafollicular B cell differentiation into short-lived AFCs as a key mechanism of anti-DNA autoreactivity and reveal a major contribution of pDCs, endosomal Toll-like receptors (TLRs), and IFN-I to this pathway.</div> <div itemprodp="datePublished">Tue Jun 16 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31761564"> <div itemprop="name">Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4<sup>+</sup> T Cell Pathogenicity and Suppresses Autoimmunity.</div> </a> <div itemprop="about">Cell metabolism</div> <div itemprop="author">Angiari S,Runtsch MC,Sutton CE,Palsson-McDermott EM,Kelly B,Rana N,Kane H,Papadopoulou G,Pearce EL,Mills KHG,O'Neill LAJ</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Feb 04 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31932810"> <div itemprop="name">Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Aegerter H,Kulikauskaite J,Crotta S,Patel H,Kelly G,Hessel EM,Mack M,Beinke S,Wack A</div> <div itemprop="description">17-0441-83 was used in Flow Cytometry to understand how transient respiratory infections, a common occurrence in human life, can constantly alter lung immunity by contributing monocyte-derived, recruited cells to the AM population.</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32231298"> <div itemprop="name">Beta cell-specific CD8<sup>+</sup> T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Abdelsamed HA,Zebley CC,Nguyen H,Rutishauser RL,Fan Y,Ghoneim HE,Crawford JC,Alfei F,Alli S,Ribeiro SP,Castellaw AH,McGargill MA,Jin H,Boi SK,Speake C,Serti E,Turka LA,Busch ME,Stone M,Deeks SG,Sekaly RP,Zehn D,James EA,Nepom GT,Youngblood B</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the long-lived nature of these cells, we established a DNA methylation-based T cell 'multipotency index' and found that beta cell-specific CD8+ T cells retained a stem-like epigenetic multipotency score.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32898324"> <div itemprop="name">Transfer of metastatic traits via miR-200c in extracellular vesicles derived from colorectal cancer stem cells is inhibited by atractylenolide I.</div> </a> <div itemprop="about">Clinical and translational medicine</div> <div itemprop="author">Tang D,Xu X,Ying J,Xie T,Cao G</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32437509"> <div itemprop="name">PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.</div> </a> <div itemprop="about">The Journal of cell biology</div> <div itemprop="author">Xu X,Hou B,Fulzele A,Masubuchi T,Zhao Y,Wu Z,Hu Y,Jiang Y,Ma Y,Wang H,Bennett EJ,Fu G,Hui E</div> <div itemprop="description">17-0441-83 was used in Flow Cytometry to compare the abilities of BTLA and PD-1 to recruit effector molecules and to regulate T cell signalling.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31600013"> <div itemprop="name">Distinct roles of PIK3CA in the enrichment and maintenance of cancer stem cells in head and neck squamous cell carcinoma.</div> </a> <div itemprop="about">Molecular oncology</div> <div itemprop="author">Chen X,Cao Y,Sedhom W,Lu L,Liu Y,Wang H,Oka M,Bornstein S,Said S,Song J,Lu SL</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jan 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32432109"> <div itemprop="name">Down-Regulated Exosomal MicroRNA-221 - 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Sun L,Zhu W,Zhao P,Zhang J,Lu Y,Zhu Y,Zhao W,Liu Y,Chen Q,Zhang F</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32432109"> <div itemprop="name">Down-Regulated Exosomal MicroRNA-221 - 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair.</div> </a> <div itemprop="about">Frontiers in cell and developmental biology</div> <div itemprop="author">Sun L,Zhu W,Zhao P,Zhang J,Lu Y,Zhu Y,Zhao W,Liu Y,Chen Q,Zhang F</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32705164"> <div itemprop="name">Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4.</div> </a> <div itemprop="about">International journal of oncology</div> <div itemprop="author">Jiang Z,Zhang C,Liu X,Ma X,Bian X,Xiao X,Gao R,Sun Y,Wu W,Zhao P</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32963751"> <div itemprop="name">Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues.</div> </a> <div itemprop="about">Therapeutic advances in chronic disease</div> <div itemprop="author">Zhang C,Gu X,Zhao G,Wang W,Shao J,Zhu J,Yuan T,Sun J,Nie D,Zhou Y</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Apr 17 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32323777"> <div itemprop="name">miR‑210 enhances mesenchymal stem cell‑modulated neural precursor cell migration.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Wang F,Zhu J,Zheng J,Duan W,Zhou Z</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32319646"> <div itemprop="name">Identification, characterization and microRNA expression profiling of side population cells in human oral squamous cell carcinoma Tca8113 cell lines.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Luo W,Liu RS,E LL,Bai Y,Kong XP,Liu HW,Wu H,Liu HC</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32319646"> <div itemprop="name">Identification, characterization and microRNA expression profiling of side population cells in human oral squamous cell carcinoma Tca8113 cell lines.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Luo W,Liu RS,E LL,Bai Y,Kong XP,Liu HW,Wu H,Liu HC</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32186753"> <div itemprop="name">Resveratrol rescues TNF‑α‑induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Yuan J,Wang X,Ma D,Gao H,Zheng D,Zhang J</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33051000"> <div itemprop="name">Critical role of WNK1 in MYC-dependent early mouse thymocyte development.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Oct 14 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33051000"> <div itemprop="name">Critical role of WNK1 in MYC-dependent early mouse thymocyte development.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Oct 14 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32456187"> <div itemprop="name">Effect of Combining Low Temperature Plasma, Negative Pressure Wound Therapy, and Bone Marrow Mesenchymal Stem Cells on an Acute Skin Wound Healing Mouse Model.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Cui HS,Joo SY,Cho YS,Park JH,Kim JB,Seo CH</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat May 23 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33298190"> <div itemprop="name">Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases.</div> </a> <div itemprop="about">Stem cell research & therapy</div> <div itemprop="author">Tobias IC,Kao MC,Parmentier T,Hunter H,LaMarre J,Betts DH</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Dec 09 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31936348"> <div itemprop="name">Chemotherapeutic Stress Influences Epithelial-Mesenchymal Transition and Stemness in Cancer Stem Cells of Triple-Negative Breast Cancer.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Li X,Strietz J,Bleilevens A,Stickeler E,Maurer J</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jan 08 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33262329"> <div itemprop="name">Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Wang Y,Wang Q,Wang B,Gu Y,Yu H,Yang W,Ren X,Qian F,Zhao X,Xiao Y,Zhang Y,Jin M,Zhu M</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32455980"> <div itemprop="name">Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Witschen PM,Chaffee TS,Brady NJ,Huggins DN,Knutson TP,LaRue RS,Munro SA,Tiegs L,McCarthy JB,Nelson AC,Schwertfeger KL</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri May 22 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32455980"> <div itemprop="name">Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Witschen PM,Chaffee TS,Brady NJ,Huggins DN,Knutson TP,LaRue RS,Munro SA,Tiegs L,McCarthy JB,Nelson AC,Schwertfeger KL</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri May 22 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32390999"> <div itemprop="name">Utility Evaluation of Porcine Enteroids as PDCoV Infection Model <i>in vitro</i>.</div> </a> <div itemprop="about">Frontiers in microbiology</div> <div itemprop="author">Luo H,Zheng J,Chen Y,Wang T,Zhang Z,Shan Y,Xu J,Yue M,Fang W,Li X</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32708734"> <div itemprop="name">Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Goričan L,Gole B,Potočnik U</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jul 16 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32326381"> <div itemprop="name">Obesity-Altered Adipose Stem Cells Promote Radiation Resistance of Estrogen Receptor Positive Breast Cancer through Paracrine Signaling.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Sabol RA,Villela VA,Denys A,Freeman BT,Hartono AB,Wise RM,Harrison MAA,Sandler MB,Hossain F,Miele L,Bunnell BA</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Apr 15 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32300100"> <div itemprop="name">CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Huang R,Wang S,Wang N,Zheng Y,Zhou J,Yang B,Wang X,Zhang J,Guo L,Wang S,Chen Z,Wang Z,Xiang S</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 16 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33322565"> <div itemprop="name">Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Pasquale V,Ducci G,Campioni G,Ventrici A,Assalini C,Busti S,Vanoni M,Vago R,Sacco E</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 11 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33322565"> <div itemprop="name">Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties.</div> </a> <div itemprop="about">Cells</div> <div itemprop="author">Pasquale V,Ducci G,Campioni G,Ventrici A,Assalini C,Busti S,Vanoni M,Vago R,Sacco E</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 11 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32467752"> <div itemprop="name">Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.</div> </a> <div itemprop="about">Cell & bioscience</div> <div itemprop="author">Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Apr 14 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31995749"> <div itemprop="name">Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Piao W,Xiong Y,Li L,Saxena V,Smith KD,Hippen KL,Paluskievicz C,Willsonshirkey M,Blazar BR,Abdi R,Bromberg JS</div> <div itemprop="description">17-0441-82 was used in Flow Cytometry to demonstrate the role of regulatory T cells in enhancing leukocyte migration through endothelial barriers.</div> <div itemprodp="datePublished">Tue Jan 28 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32632165"> <div itemprop="name">Requirements for the differentiation of innate T-bet<sup>high</sup> memory-phenotype CD4<sup>+</sup> T lymphocytes under steady state.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 06 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33584640"> <div itemprop="name">Developmental Dysfunction of the Central Nervous System Lymphatics Modulates the Adaptive Neuro-Immune Response in the Perilesional Cortex in a Mouse Model of Traumatic Brain Injury.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Wojciechowski S,Virenque A,Vihma M,Galbardi B,Rooney EJ,Keuters MH,Antila S,Koistinaho J,Noe FM</div> <div itemprop="description">17-0441-82 was used in Flow Cytometry to explore the role of meningeal lymphatic vessels in modulating the neuro-immune response following a traumatic brain injury.</div> <div itemprodp="datePublished">Wed May 19 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32421748"> <div itemprop="name">Graphene-based 2D constructs for enhanced fibroblast support.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Safina I,Bourdo SE,Algazali KM,Kannarpady G,Watanabe F,Vang KB,Biris AS</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Tue Aug 04 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32421748"> <div itemprop="name">Graphene-based 2D constructs for enhanced fibroblast support.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Safina I,Bourdo SE,Algazali KM,Kannarpady G,Watanabe F,Vang KB,Biris AS</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Immunocytochemistry</div> <div itemprodp="datePublished">Tue Aug 04 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32553171"> <div itemprop="name">Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Siamishi I,Iwanami N,Clapes T,Trompouki E,O'Meara CP,Boehm T</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to serve as a paradigm to understand the molecular basis of cell-type-specific non-replicative functions of the ubiquitous POLE complex.</div> <div itemprodp="datePublished">Tue Jun 16 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32709874"> <div itemprop="name">Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jul 24 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32181368"> <div itemprop="name">Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Chao Y,Liang C,Tao H,Du Y,Wu D,Dong Z,Jin Q,Chen G,Xu J,Xiao Z,Chen Q,Wang C,Chen J,Liu Z</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33033262"> <div itemprop="name">JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Huang Y,Zhang H,Wang L,Tang C,Qin X,Wu X,Pan M,Tang Y,Yang Z,Babarinde IA,Lin R,Ji G,Lai Y,Xu X,Su J,Wen X,Satoh T,Ahmed T,Malik V,Ward C,Volpe G,Guo L,Chen J,Sun L,Li Y,Huang X,Bao X,Gao F,Liu B,Zheng H,Jauch R,Lai L,Pan G,Chen J,Testa G,Akira S,Hu J,Pei D,Hutchins AP,Esteban MA,Qin B</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to establish a multifaceted role for JMJD3, placing it as a key partner of KLF4 and a scaffold that assists chromatin interactions and activates gene transcription.</div> <div itemprodp="datePublished">Thu Oct 08 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32585597"> <div itemprop="name">Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Iwanami N,Takeshita K,Lawir DF,Suetake I,Tajima S,Sikora K,Trancoso I,ÓMeara C,Siamishi I,Takahama Y,Furutani-Seiki M,Kondoh H,Yonezawa Y,Schorpp M,Boehm T</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to identify new recessive dnmt1 alleles in medaka and zebrafish and, guided by the structures of mutant proteins, generated a recessive variant of mouse Dnmt1.</div> <div itemprodp="datePublished">Fri Jul 24 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31128961"> <div itemprop="name">Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Walker JA,Clark PA,Crisp A,Barlow JL,Szeto A,Ferreira ACF,Rana BMJ,Jolin HE,Rodriguez-Rodriguez N,Sivasubramaniam M,Pannell R,Cruickshank J,Daly M,Haim-Vilmovsky L,Teichmann SA,McKenzie ANJ</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to identify a discrete ILC2-committed population and delineated transition states between early progenitors and a highly heterogeneous ILC1, ILC3, and NK precursor cell cluster.</div> <div itemprodp="datePublished">Tue Jul 16 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31784259"> <div itemprop="name">Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.</div> </a> <div itemprop="about">Cell host & microbe</div> <div itemprop="author">Leech JM,Dhariwala MO,Lowe MM,Chu K,Merana GR,Cornuot C,Weckel A,Ma JM,Leitner EG,Gonzalez JR,Vasquez KS,Diep BA,Scharschmidt TC</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Dec 11 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31784259"> <div itemprop="name">Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.</div> </a> <div itemprop="about">Cell host & microbe</div> <div itemprop="author">Leech JM,Dhariwala MO,Lowe MM,Chu K,Merana GR,Cornuot C,Weckel A,Ma JM,Leitner EG,Gonzalez JR,Vasquez KS,Diep BA,Scharschmidt TC</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Dec 11 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31630621"> <div itemprop="name">A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation.</div> </a> <div itemprop="about">Circulation research</div> <div itemprop="author">Lu X,Rudemiller NP,Wen Y,Ren J,Hammer GE,Griffiths R,Privratsky JR,Yang B,Sparks MA,Crowley SD</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 06 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31630621"> <div itemprop="name">A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation.</div> </a> <div itemprop="about">Circulation research</div> <div itemprop="author">Lu X,Rudemiller NP,Wen Y,Ren J,Hammer GE,Griffiths R,Privratsky JR,Yang B,Sparks MA,Crowley SD</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 06 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30770367"> <div itemprop="name">A Novel Form of 4-1BBL Prevents Cancer Development via Nonspecific Activation of CD4<sup>+</sup> T and Natural Killer Cells.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Barsoumian HB,Batra L,Shrestha P,Bowen WS,Zhao H,Egilmez NK,Gomez-Gutierrez JG,Yolcu ES,Shirwan H</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Feb 15 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31694869"> <div itemprop="name">Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.</div> </a> <div itemprop="about">Genome research</div> <div itemprop="author">Alriyami M,Marchand L,Li Q,Du X,Olivier M,Polychronakos C</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31648279"> <div itemprop="name">The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Tuladhar S,Kochanowsky JA,Bhaskara A,Ghotmi Y,Chandrasekaran S,Koshy AA</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31638182"> <div itemprop="name">Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNA‑Meg3/miR‑421/PDGFRA axis.</div> </a> <div itemprop="about">International journal of oncology</div> <div itemprop="author">Ye W,Ni Z,Yicheng S,Pan H,Huang Y,Xiong Y,Liu T</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31381839"> <div itemprop="name">Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Menon V,Thomas R,Elgueta C,Horl M,Osborn T,Hallett PJ,Bartos M,Isacson O,Pruszak J</div> <div itemprop="description"></div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30628201"> <div itemprop="name">Hypoxia changes chemotaxis behaviour of mesenchymal stem cells via HIF-1α signalling.</div> </a> <div itemprop="about">Journal of cellular and molecular medicine</div> <div itemprop="author">Xu W,Xu R,Li Z,Wang Y,Hu R</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31885626"> <div itemprop="name">Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.</div> </a> <div itemprop="about">Stem cells international</div> <div itemprop="author">Sun B,Luo X,Yang C,Liu P,Yang Y,Dong X,Yang Z,Xu J,Zhang Y,Li L</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu May 13 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31213919"> <div itemprop="name">HMGB3 silence inhibits breast cancer cell proliferation and tumor growth by interacting with hypoxia-inducible factor 1α.</div> </a> <div itemprop="about">Cancer management and research</div> <div itemprop="author">Gu J,Xu T,Huang QH,Zhang CM,Chen HY</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 29 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31432132"> <div itemprop="name">TGF‑β induces periodontal ligament stem cell senescence through increase of ROS production.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Fan C,Ji Q,Zhang C,Xu S,Sun H,Li Z</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31059010"> <div itemprop="name">Effects of leukemia inhibitory factor receptor on the adipogenic differentiation of human bone marrow mesenchymal stem cells.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Wang T,Yan R,Xu X,Yu H,Wu J,Yang Y,Li W</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to show that Leukemia inhibitory factor receptor promoted adipogenic differentiation, whereas LIF may negatively regulate this process.</div> <div itemprodp="datePublished">Sat Jun 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30988736"> <div itemprop="name">Effects of demographic factors on adipogenic and chondrogenic differentiation in bone marrow-derived stem cells.</div> </a> <div itemprop="about">Experimental and therapeutic medicine</div> <div itemprop="author">Lee H,Min SK,Park JB</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31685442"> <div itemprop="name">The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway.</div> </a> <div itemprop="about">EBioMedicine</div> <div itemprop="author">Seo D,Jung SM,Park JS,Lee J,Ha J,Kim M,Park SH</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31861872"> <div itemprop="name">Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Huang JY,Wang YY,Lo S,Tseng LM,Chen DR,Wu YC,Hou MF,Yuan SF</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 20 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30994416"> <div itemprop="name">Better therapeutic potential of bone marrow-derived mesenchymal stem cells compared with chorionic villi-derived mesenchymal stem cells in airway injury model.</div> </a> <div itemprop="about">Regenerative medicine</div> <div itemprop="author">Ji S,Wu C,Tong L,Wang L,Zhou J,Chen C,Song Y</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30816208"> <div itemprop="name">Overexpression of Aiolos promotes epithelial-mesenchymal transition and cancer stem cell-like properties in lung cancer cells.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Hung JJ,Kao YS,Huang CH,Hsu WH</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Feb 28 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31130822"> <div itemprop="name">BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway.</div> </a> <div itemprop="about">Cancer cell international</div> <div itemprop="author">Xu XF,Gao F,Wang JJ,Long C,Chen X,Tao L,Yang L,Ding L,Ji Y</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 08 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30700819"> <div itemprop="name">Sex Differences in Mouse Popliteal Lymph Nodes.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Dill-Garlow R,Chen KE,Walker AM</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jan 30 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30894532"> <div itemprop="name">ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 20 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30894532"> <div itemprop="name">ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 20 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30894532"> <div itemprop="name">ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 20 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31018134"> <div itemprop="name">Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Zhu X,Zhang W,Guo J,Zhang X,Li L,Wang T,Yan J,Zhang F,Hou B,Gao N,Gao GF,Zhou X</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to identify the control of Treg activation and immune tolerance maintenance is due to Noc4L mediated ribosome biogenesis.</div> <div itemprodp="datePublished">Tue Apr 23 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30840882"> <div itemprop="name">Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Colunga T,Hayworth M,Kreß S,Reynolds DM,Chen L,Nazor KL,Baur J,Singh AM,Loring JF,Metzger M,Dalton S</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Mar 05 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31273285"> <div itemprop="name">BRCA1 regulates the cancer stem cell fate of breast cancer cells in the context of hypoxia and histone deacetylase inhibitors.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Kim H,Lin Q,Yun Z</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jul 04 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30699352"> <div itemprop="name">Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8<sup>+</sup> T Cell Responses.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Cousin C,Oberkampf M,Felix T,Rosenbaum P,Weil R,Fabrega S,Morante V,Negri D,Cara A,Dadaglio G,Leclerc C</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to demonstrate that integrase-deficient lentiviral vectors can trigger persistent adaptive response by the mediation of a weak and transient innate response alongside the persistence of the vector in tissues.</div> <div itemprodp="datePublished">Tue Jan 29 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30841538"> <div itemprop="name">Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Camps J,Grosemans H,Gijsbers R,Maes C,Sampaolesi M</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Mar 05 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30841538"> <div itemprop="name">Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells.</div> </a> <div itemprop="about">International journal of molecular sciences</div> <div itemprop="author">Camps J,Grosemans H,Gijsbers R,Maes C,Sampaolesi M</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Mar 05 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30704403"> <div itemprop="name">Conserved regulation of RNA processing in somatic cell reprogramming.</div> </a> <div itemprop="about">BMC genomics</div> <div itemprop="author">Kanitz A,Syed AP,Kaji K,Zavolan M</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jan 31 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29440425"> <div itemprop="name">Bryostatin-1 alleviates experimental multiple sclerosis.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Feb 27 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29937544"> <div itemprop="name">Interaction of WBP2 with ERα increases doxorubicin resistance of breast cancer cells by modulating MDR1 transcription.</div> </a> <div itemprop="about">British journal of cancer</div> <div itemprop="author">Chen S,Wang H,Li Z,You J,Wu QW,Zhao C,Tzeng CM,Zhang ZM</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study ERα-mediated drug-resistant mechanisms in breast cancer.</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29946322"> <div itemprop="name">The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Baur J,Otto C,Steger U,Klein-Hessling S,Muhammad K,Pusch T,Murti K,Wismer R,Germer CT,Klein I,Müller N,Serfling E,Avots A</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to show that the activity of nuclear factors of activated T cells-c1 supports the acute rejection of heterotopic heart allografts.</div> <div itemprodp="datePublished">Wed Nov 20 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29670624"> <div itemprop="name">Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Haug M,Brede G,Håkerud M,Nedberg AG,Gederaas OA,Flo TH,Edwards VT,Selbo PK,Høgset A,Halaas Ø</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study the ability of photochemical internalisation as a vaccination technology to induce priming of cancer-specific CD8+ cytotoxic T lymphocytes.</div> <div itemprodp="datePublished">Mon Jun 24 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29892289"> <div itemprop="name">Varying Immunizations With <i>Plasmodium</i> Radiation-Attenuated Sporozoites Alter Tissue-Specific CD8<sup>+</sup> T Cell Dynamics.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Frank R,Gabel M,Heiss K,Mueller AK,Graw F</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to determine how the generation of immunity is affected by vaccination dosage and frequency.</div> <div itemprodp="datePublished">Tue Jul 30 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29343849"> <div itemprop="name">Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.</div> </a> <div itemprop="about">Oncogene</div> <div itemprop="author">Solomon H,Dinowitz N,Pateras IS,Cooks T,Shetzer Y,Molchadsky A,Charni M,Rabani S,Koifman G,Tarcic O,Porat Z,Kogan-Sakin I,Goldfinger N,Oren M,Harris CC,Gorgoulis VG,Rotter V</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Mar 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29510720"> <div itemprop="name">The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells.</div> </a> <div itemprop="about">Breast cancer research : BCR</div> <div itemprop="author">Kim H,Lin Q,Glazer PM,Yun Z</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Mar 06 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29229751"> <div itemprop="name">SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.</div> </a> <div itemprop="about">The Journal of cell biology</div> <div itemprop="author">Viotti M,Wilson C,McCleland M,Koeppen H,Haley B,Jhunjhunwala S,Klijn C,Modrusan Z,Arnott D,Classon M,Stephan JP,Mellman I</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 05 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29229751"> <div itemprop="name">SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.</div> </a> <div itemprop="about">The Journal of cell biology</div> <div itemprop="author">Viotti M,Wilson C,McCleland M,Koeppen H,Haley B,Jhunjhunwala S,Klijn C,Modrusan Z,Arnott D,Classon M,Stephan JP,Mellman I</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Feb 05 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30402111"> <div itemprop="name"><i>In Vitro</i> Expansion and Characterization of Mesenchymal Stromal Cells from Peritoneal Dialysis Effluent in a Human Protein Medium.</div> </a> <div itemprop="about">Stem cells international</div> <div itemprop="author">Han B,Zhou L,Guan Q,da Roza G,Wang H,Du C</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to show that upon expansion in a human protein medium, pMSCs shows a differential MSC marker expression profile from those of bone marrow or adipose tissue-derived MSCs and could maintain the multipotency.</div> <div itemprodp="datePublished">Wed Sep 30 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29434774"> <div itemprop="name">Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of <i>Cx37</i>, <i>Cx40</i> and <i>Cx43</i>.</div> </a> <div itemprop="about">Experimental and therapeutic medicine</div> <div itemprop="author">Li Z,Zhang S,Cao L,Li W,Ye YC,Shi ZX,Wang ZR,Sun LX,Wang JW,Jia LT,Wang W</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Feb 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33817078"> <div itemprop="name">mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis.</div> </a> <div itemprop="about">Open life sciences</div> <div itemprop="author">Wang H,Xiao Y,Su L,Cui N,Liu D</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jan 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30208924"> <div itemprop="name">LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients.</div> </a> <div itemprop="about">Journal of experimental & clinical cancer research : CR</div> <div itemprop="author">Zhang J,Cai H,Sun L,Zhan P,Chen M,Zhang F,Ran Y,Wan J</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to determine whether leucine-rich repeat-containing G protein-coupled receptor 5 can serve as a novel glioma stem cell marker involved in epithelial-mesenchymal transition and a therapeutic target in glioma.</div> <div itemprodp="datePublished">Wed Sep 12 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29593314"> <div itemprop="name">Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 28 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30540939"> <div itemprop="name">Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Simula L,Pacella I,Colamatteo A,Procaccini C,Cancila V,Bordi M,Tregnago C,Corrado M,Pigazzi M,Barnaba V,Tripodo C,Matarese G,Piconese S,Campello S</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to describe the crucial role of the mitochondrial protein Drp1 in T cell development and regulation of lymphocyte immune-surveillance.</div> <div itemprodp="datePublished">Tue Dec 11 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29925006"> <div itemprop="name">Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Kirkling ME,Cytlak U,Lau CM,Lewis KL,Resteu A,Khodadadi-Jamayran A,Siebel CW,Salmon H,Merad M,Tsirigos A,Collin M,Bigley V,Reizis B</div> <div itemprop="description"></div> <div itemprodp="datePublished">Tue Jun 19 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29899829"> <div itemprop="name">Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Huang W,Bei L,Eklund EA</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri May 25 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30059005"> <div itemprop="name">An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Li J,Choi PS,Chaffer CL,Labella K,Hwang JH,Giacomelli AO,Kim JW,Ilic N,Doench JG,Ly SH,Dai C,Hagel K,Hong AL,Gjoerup O,Goel S,Ge JY,Root DE,Zhao JJ,Brooks AN,Weinberg RA,Hahn WC</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 30 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30410056"> <div itemprop="name">Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Nov 08 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29515165"> <div itemprop="name">Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Ding Y,Liang X,Zhang Y,Yi L,Shum HC,Chen Q,Chan BP,Fan H,Liu Z,Tergaonkar V,Qi Z,Tse HF,Lian Q</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to indicate that Rap1 is essential to maintain the immunomodulatory function of MSCs.</div> <div itemprodp="datePublished">Wed Mar 07 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29700112"> <div itemprop="name">RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 15 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29700112"> <div itemprop="name">RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 15 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29708496"> <div itemprop="name">Reduced expression of C/EBPβ-LIP extends health and lifespan in mice.</div> </a> <div itemprop="about">eLife</div> <div itemprop="author">Müller C,Zidek LM,Ackermann T,de Jong T,Liu P,Kliche V,Zaini MA,Kortman G,Harkema L,Verbeek DS,Tuckermann JP,von Maltzahn J,de Bruin A,Guryev V,Wang ZQ,Calkhoven CF</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to reveal a role for C/EBPβ in the aging process and suggest that restriction of LIP expression sustains health and fitness.</div> <div itemprodp="datePublished">Mon Jun 04 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29314730"> <div itemprop="name">Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.</div> </a> <div itemprop="about">Immunity, inflammation and disease</div> <div itemprop="author">Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to show that despite impaired proliferation and IL2 production, tolerant T cells can display inflammatory responses in response to antigen stimulation and this is controlled at least partly by Egr2 and 3.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30566862"> <div itemprop="name">Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Chiou NT,Kageyama R,Ansel KM</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 18 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28902840"> <div itemprop="name">Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Kim S,Kim H,Yim YS,Ha S,Atarashi K,Tan TG,Longman RS,Honda K,Littman DR,Choi GB,Huh JR</div> <div itemprop="description"></div> <div itemprodp="datePublished">Thu Sep 28 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29198913"> <div itemprop="name">Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.</div> </a> <div itemprop="about">Cancer cell</div> <div itemprop="author">Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Dec 11 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29174331"> <div itemprop="name">Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">Ruetz T,Pfisterer U,Di Stefano B,Ashmore J,Beniazza M,Tian TV,Kaemena DF,Tosti L,Tan W,Manning JR,Chantzoura E,Ottosson DR,Collombet S,Johnsson A,Cohen E,Yusa K,Linnarsson S,Graf T,Parmar M,Kaji K</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Dec 07 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28067667"> <div itemprop="name">Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28487311"> <div itemprop="name">Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jun 05 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28389502"> <div itemprop="name">DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Lehmann CHK,Baranska A,Heidkamp GF,Heger L,Neubert K,Lühr JJ,Hoffmann A,Reimer KC,Brückner C,Beck S,Seeling M,Kießling M,Soulat D,Krug AB,Ravetch JV,Leusen JHW,Nimmerjahn F,Dudziak D</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to suggest that targeting antigens to FcγRs on DCs may be a promising approach to raise immunogenic or tolerogenic T cell responses to antigens of choice.</div> <div itemprodp="datePublished">Mon May 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28202520"> <div itemprop="name">Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Sansone P,Berishaj M,Rajasekhar VK,Ceccarelli C,Chang Q,Strillacci A,Savini C,Shapiro L,Bowman RL,Mastroleo C,De Carolis S,Daly L,Benito-Martin A,Perna F,Fabbri N,Healey JH,Spisni E,Cricca M,Lyden D,Bonafé M,Bromberg J</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study the importance of microvesicle-mediated horizontal transfer of genetic material from stromal cells to cancer cells in the evolution of therapy-resistant metastases.</div> <div itemprodp="datePublished">Sat Apr 15 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28270621"> <div itemprop="name">Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Bierie B,Pierce SE,Kroeger C,Stover DG,Pattabiraman DR,Thiru P,Liu Donaher J,Reinhardt F,Chaffer CL,Keckesova Z,Weinberg RA</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Mar 21 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27166557"> <div itemprop="name">CD4<sup>+</sup> Th2 cells are directly regulated by IL-10 during allergic airway inflammation.</div> </a> <div itemprop="about">Mucosal immunology</div> <div itemprop="author">Coomes SM,Kannan Y,Pelly VS,Entwistle LJ,Guidi R,Perez-Lloret J,Nikolov N,Müller W,Wilson MS</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to identify that pathogenic Th2 cells are an important direct target of IL-10 and an insight into IL-10 mediated regualation of allergic airway inflammation.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28066899"> <div itemprop="name">A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8<sup>+</sup> T cells.</div> </a> <div itemprop="about">Immunology</div> <div itemprop="author">Förster M,Boora RK,Petrov JC,Fodil N,Albanese I,Kim J,Gros P,Nijnik A</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the role of MYSM1 in T-cell development.</div> <div itemprodp="datePublished">Mon May 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28485322"> <div itemprop="name">Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8<sup>+</sup> T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.</div> </a> <div itemprop="about">Chinese medical journal</div> <div itemprop="author">Cui N,Wang H,Su LX,Zhang JH,Long Y,Liu DW</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat May 20 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28696253"> <div itemprop="name">The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Sitrin J,Suto E,Wuster A,Eastham-Anderson J,Kim JM,Austin CD,Lee WP,Behrens TW</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Aug 15 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28680570"> <div itemprop="name">A high-yield isolation and enrichment strategy for human lung microvascular endothelial cells.</div> </a> <div itemprop="about">Pulmonary circulation</div> <div itemprop="author">Gaskill C,Majka SM</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27987073"> <div itemprop="name">Comparison of Four Protocols to Generate Chondrocyte-Like Cells from Human Induced Pluripotent Stem Cells (hiPSCs).</div> </a> <div itemprop="about">Stem cell reviews and reports</div> <div itemprop="author">Suchorska WM,Augustyniak E,Richter M,Trzeciak T</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Apr 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28148288"> <div itemprop="name">Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer.</div> </a> <div itemprop="about">Molecular cancer</div> <div itemprop="author">Duhachek-Muggy S,Qi Y,Wise R,Alyahya L,Li H,Hodge J,Zolkiewska A</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate whether ADAM12 plays an active role in promoting the cancer stem cell phenotype in breast cancer cells.</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28963568"> <div itemprop="name">Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Sep 29 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29021521"> <div itemprop="name">Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Oct 11 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28839461"> <div itemprop="name">Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling.</div> </a> <div itemprop="about">Theranostics</div> <div itemprop="author">Cao Y,Lin SH,Wang Y,Chin YE,Kang L,Mi J</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Apr 30 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29202461"> <div itemprop="name">IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Nov 16 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28542307"> <div itemprop="name">The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Laroque A,Min-Oo G,Tam M,Ponka P,Stevenson MM,Gros P</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study the mechanistic basis of the Char10 effect.</div> <div itemprodp="datePublished">Tue Sep 12 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28418931"> <div itemprop="name">SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destruction.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Gao Z,Jin YQ,Wu W</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 16 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28515365"> <div itemprop="name">Ceramide synthesis regulates T cell activity and GVHD development.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Sofi MH,Heinrichs J,Dany M,Nguyen H,Dai M,Bastian D,Schutt S,Wu Y,Daenthanasanmak A,Gencer S,Zivkovic A,Szulc Z,Stark H,Liu C,Chang YJ,Ogretmen B,Yu XZ</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to define the involvement of ceramides in the T-cell response to alloantigens present after allogeneic haematopoietic cell transplantation.</div> <div itemprodp="datePublished">Thu May 18 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28894104"> <div itemprop="name">NFATc1 controls the cytotoxicity of CD8<sup>+</sup> T cells.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Klein-Hessling S,Muhammad K,Klein M,Pusch T,Rudolf R,Flöter J,Qureischi M,Beilhack A,Vaeth M,Kummerow C,Backes C,Schoppmeyer R,Hahn U,Hoth M,Bopp T,Berberich-Siebelt F,Patra A,Avots A,Müller N,Schulze A,Serfling E</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to indicate that NFATc1 is an important regulator of cytotoxic T lymphocyte effector functions.</div> <div itemprodp="datePublished">Mon Sep 11 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29216265"> <div itemprop="name">OCT4 expression mediates partial cardiomyocyte reprogramming of mesenchymal stromal cells.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Yannarelli G,Pacienza N,Montanari S,Santa-Cruz D,Viswanathan S,Keating A</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to infer that OCT4 expression may have a direct effect on partial cardiomyocyte reprogramming of mesenchymal stromal cells.</div> <div itemprodp="datePublished">Tue Dec 26 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29042531"> <div itemprop="name">Extrafollicular CD4<sup>+</sup> T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 17 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29042531"> <div itemprop="name">Extrafollicular CD4<sup>+</sup> T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 17 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28202042"> <div itemprop="name">HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.</div> </a> <div itemprop="about">Molecular cancer</div> <div itemprop="author">Shah M,Cardenas R,Wang B,Persson J,Mongan NP,Grabowska A,Allegrucci C</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Feb 16 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28594896"> <div itemprop="name">Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Sep 18 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27064903"> <div itemprop="name">Metabolic maintenance of cell asymmetry following division in activated T lymphocytes.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Verbist KC,Guy CS,Milasta S,Liedmann S,Kamiński MM,Wang R,Green DR</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the mechanisms that sustain differential cell fates in daughter T cells after activation by an antigen-presenting cell.</div> <div itemprodp="datePublished">Thu Apr 21 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26656646"> <div itemprop="name">Oligodendrocyte death results in immune-mediated CNS demyelination.</div> </a> <div itemprop="about">Nature neuroscience</div> <div itemprop="author">Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27551157"> <div itemprop="name">NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Drennan MB,Govindarajan S,Verheugen E,Coquet JM,Staal J,McGuire C,Taghon T,Leclercq G,Beyaert R,van Loo G,Lambrecht BN,Elewaut D</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to show that negative regulation of TCR signalling during NKT development controls the differentiation and survival of NKT1 and NKT2 cells.</div> <div itemprodp="datePublished">Mon Sep 19 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26677875"> <div itemprop="name">Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Cheung SK,Chuang PK,Huang HW,Hwang-Verslues WW,Cho CH,Yang WB,Shen CN,Hsiao M,Hsu TL,Chang CF,Wong CH</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate significant markers for breast cancer stem cells, such as (SSEA-3) and β3GalT5.</div> <div itemprodp="datePublished">Tue Jan 26 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27880766"> <div itemprop="name">SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.</div> </a> <div itemprop="about">PLoS biology</div> <div itemprop="author">Kim BR,Van de Laar E,Cabanero M,Tarumi S,Hasenoeder S,Wang D,Virtanen C,Suzuki T,Bandarchi B,Sakashita S,Pham NA,Lee S,Keshavjee S,Waddell TK,Tsao MS,Moghal N</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27014269"> <div itemprop="name">Generation of the First TCR Transgenic Mouse with CD4(+) T Cells Recognizing an Anti-inflammatory Regulatory T Cell-Inducing Hsp70 Peptide.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Jansen MA,van Herwijnen MJ,van Kooten PJ,Hoek A,van der Zee R,van Eden W,Broere F</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to generate a novel mouse model to allow the study of primary antigen-specific T cells.</div> <div itemprodp="datePublished">Fri Mar 25 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26869189"> <div itemprop="name">Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Park JW,Park JM,Park DM,Kim DY,Kim HK</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26822477"> <div itemprop="name">Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade.</div> </a> <div itemprop="about">Disease models & mechanisms</div> <div itemprop="author">Atkinson SM,Hoffmann U,Hamann A,Bach E,Danneskiold-Samsøe NB,Kristiansen K,Serikawa K,Fox B,Kruse K,Haase C,Skov S,Nansen A</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the role of regulatory T cells in delayed-type hypersensitivity arthritis through depletion, and the rescuing effect of IL-7 in connection to regulatory T cell depletion.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27357149"> <div itemprop="name">Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Menendez CM,Jinkins JK,Carr DJ</div> <div itemprop="description"></div> <div itemprodp="datePublished">Mon Aug 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27385780"> <div itemprop="name">Protein Translation Activity: A New Measure of Host Immune Cell Activation.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Seedhom MO,Hickman HD,Wei J,David A,Yewdell JW</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to describe the in vivo ribopuromycylation method.</div> <div itemprodp="datePublished">Mon Aug 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26572749"> <div itemprop="name">Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Hu Y,Zhang Y,Tian K,Xun C,Wang S,Lv D</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27698884"> <div itemprop="name">Comparable roles of CD44v8-10 and CD44s in the development of bone metastases in a mouse model.</div> </a> <div itemprop="about">Oncology letters</div> <div itemprop="author">Hiraga T,Nakamura H</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27313698"> <div itemprop="name">Cryptotanshinone targets tumor-initiating cells through down-regulation of stemness genes expression.</div> </a> <div itemprop="about">Oncology letters</div> <div itemprop="author">Zhang Y,Cabarcas SM,Zheng JI,Sun L,Mathews LA,Zhang X,Lin H,Farrar WL</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27106930"> <div itemprop="name">PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.</div> </a> <div itemprop="about">Biology open</div> <div itemprop="author">Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun May 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27917274"> <div itemprop="name">Sertoli cell condition medium can induce germ like cells from bone marrow derived mesenchymal stem cells.</div> </a> <div itemprop="about">Iranian journal of basic medical sciences</div> <div itemprop="author">Monfared MH,Minaee B,Rastegar T,Khrazinejad E,Barbarestani M</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26751211"> <div itemprop="name">Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Singh S,Vedi S,Samrat SK,Li W,Kumar R,Agrawal B</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the potential of a previously uncharacterized property of natural human adenovirus infection to dictate, modulate and/or alter the course of HCV infection upon exposure.</div> <div itemprodp="datePublished">Tue Jul 19 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28000790"> <div itemprop="name">A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Jeric I,Maurer G,Cavallo AL,Raguz J,Desideri E,Tarkowski B,Parrini M,Fischer I,Zatloukal K,Baccarini M</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Dec 21 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27323847"> <div itemprop="name">Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jun 21 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25410291"> <div itemprop="name">piggyBac Transposon Mediated Reprogramming and Flow Cytometry Analysis of CD44 and ICAM1 Cell-Surface Marker Changes.</div> </a> <div itemprop="about">Methods in molecular biology (Clifton, N.J.)</div> <div itemprop="author">Brightwell S,Kaji K</div> <div itemprop="description">17-0441-82 was used in Flow Cytometry to observe clear cell population changes undergoing reprogramming using two novel cell surface markers, ICAM1 and CD44 with piggyBac transposon.</div> <div itemprodp="datePublished">Fri Oct 14 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27792998"> <div itemprop="name">The long noncoding RNA HOXA11 antisense induces tumor progression and stemness maintenance in cervical cancer.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Kim HJ,Eoh KJ,Kim LK,Nam EJ,Yoon SO,Kim KH,Lee JK,Kim SW,Kim YT</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to demonstrate that HOXA11 antisense overexpression correlates with poor survival in patients with cervical cancer.</div> <div itemprodp="datePublished">Tue Dec 13 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26936133"> <div itemprop="name">Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Gomez-Rodriguez J,Meylan F,Handon R,Hayes ET,Anderson SM,Kirby MR,Siegel RM,Schwartzberg PL</div> <div itemprop="description">17-0441 was used in Magnetic cell separation to investigate the role of IL-9 in allergic asthma and autoimmunity, showing that Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.</div> <div itemprodp="datePublished">Thu Mar 03 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27317311"> <div itemprop="name">The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states.</div> </a> <div itemprop="about">BMC biology</div> <div itemprop="author">Toneff MJ,Sreekumar A,Tinnirello A,Hollander PD,Habib S,Li S,Ellis MJ,Xin L,Mani SA,Rosen JM</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 17 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27515308"> <div itemprop="name">Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production.</div> </a> <div itemprop="about">Stem cell research & therapy</div> <div itemprop="author">Camilleri ET,Gustafson MP,Dudakovic A,Riester SM,Garces CG,Paradise CR,Takai H,Karperien M,Cool S,Sampen HJ,Larson AN,Qu W,Smith J,Dietz AB,van Wijnen AJ</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 11 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26858125"> <div itemprop="name">Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Sansone P,Ceccarelli C,Berishaj M,Chang Q,Rajasekhar VK,Perna F,Bowman RL,Vidone M,Daly L,Nnoli J,Santini D,Taffurelli M,Shih NN,Feldman M,Mao JJ,Colameco C,Chen J,DeMichele A,Fabbri N,Healey JH,Cricca M,Gasparre G,Lyden D,Bonafé M,Bromberg J</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to demonstrate that hormonal therapy induces an OXPHOS metabolic editing of luminal breast cancers, establishing HT-driven self-renewal of dormant CD133(hi)/ER(lo) cells.</div> <div itemprodp="datePublished">Tue Feb 09 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26831747"> <div itemprop="name">C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Bulla R,Tripodo C,Rami D,Ling GS,Agostinis C,Guarnotta C,Zorzet S,Durigutto P,Botto M,Tedesco F</div> <div itemprop="description">17044182 was used in flow cytometry to suggest that locally synthesized C1q promotes tumor growth</div> <div itemprodp="datePublished">Mon Feb 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26789196"> <div itemprop="name">Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells.</div> </a> <div itemprop="about">PLoS genetics</div> <div itemprop="author">Lomada D,Jain M,Bolner M,Reeh KA,Kang R,Reddy MC,DiGiovanni J,Richie ER</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to demonstrate that in addition to the NFkB pathway, Stat3-mediated signals play an essential role in regulating mTEC cellularity and medullary region homeostasis.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26771353"> <div itemprop="name">Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Quattrocelli M,Giacomazzi G,Broeckx SY,Ceelen L,Bolca S,Spaas JH,Sampaolesi M</div> <div itemprop="description">17-0441 was used in Immunofluorescence to suggest that equine induced pluripotent stem cells (iPSCs) can differentiate toward muscle and cartilage, and differentiation is skewed towards the source cell lineage.</div> <div itemprodp="datePublished">Tue Jan 12 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27542214"> <div itemprop="name">Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Greenwood E,Maisel S,Ebertz D,Russ A,Pandey R,Schroeder J</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 20 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27542214"> <div itemprop="name">Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Greenwood E,Maisel S,Ebertz D,Russ A,Pandey R,Schroeder J</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 20 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25642823"> <div itemprop="name">IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Basu R,Whitley SK,Bhaumik S,Zindl CL,Schoeb TR,Benveniste EN,Pear WS,Hatton RD,Weaver CT</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to assess the ability of IL-1 to override retinoic acid-mediated expression of the transcription factor Foxp3 and induce protective TH17 cell responses.</div> <div itemprodp="datePublished">Sun Mar 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26571398"> <div itemprop="name">Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Quattrocelli M,Swinnen M,Giacomazzi G,Camps J,Barthélemy I,Ceccarelli G,Caluwé E,Grosemans H,Thorrez L,Pelizzo G,Muijtjens M,Verfaillie CM,Blot S,Janssens S,Sampaolesi M</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26571398"> <div itemprop="name">Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Quattrocelli M,Swinnen M,Giacomazzi G,Camps J,Barthélemy I,Ceccarelli G,Caluwé E,Grosemans H,Thorrez L,Pelizzo G,Muijtjens M,Verfaillie CM,Blot S,Janssens S,Sampaolesi M</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25847946"> <div itemprop="name">An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Hao B,Naik AK,Watanabe A,Tanaka H,Chen L,Richards HW,Kondo M,Taniuchi I,Kohwi Y,Kohwi-Shigematsu T,Krangel MS</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to provide a novel framework for understanding ASE function for gene expression in double-positive thymocytes.</div> <div itemprodp="datePublished">Mon May 04 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26438363"> <div itemprop="name">Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Sawada Y,Honda T,Hanakawa S,Nakamizo S,Murata T,Ueharaguchi-Tanada Y,Ono S,Amano W,Nakajima S,Egawa G,Tanizaki H,Otsuka A,Kitoh A,Dainichi T,Ogawa N,Kobayashi Y,Yokomizo T,Arita M,Nakamura M,Miyachi Y,Kabashima K</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study the inhibition of dendritic cell migration in the skin and the attenuation of contact hypersensitivity responses via Resolvin E1.</div> <div itemprodp="datePublished">Mon Oct 19 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25808869"> <div itemprop="name">Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Zhang S,Chung WC,Wu G,Egan SE,Miele L,Xu K</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri May 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26147567"> <div itemprop="name">IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Coomes SM,Pelly VS,Kannan Y,Okoye IS,Czieso S,Entwistle LJ,Perez-Lloret J,Nikolov N,Potocnik AJ,Biró J,Langhorne J,Wilson MS</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to show that co-infection with Plasmodium spp. may contribute to the chronicity of helminth infection by reducing the frequency of anti-helminth Th2 cells.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26222157"> <div itemprop="name">IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Liu G,Xu J,Wu H,Sun D,Zhang X,Zhu X,Magez S,Shi M</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the role of IL-27 in African trypanosomes infection, showing that IL-27 signalling is crucial by preventing lethal effects of CD4+ T cells and IFN-γ.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25567531"> <div itemprop="name">Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19.</div> </a> <div itemprop="about">Stem cells and development</div> <div itemprop="author">Bauderlique-Le Roy H,Vennin C,Brocqueville G,Spruyt N,Adriaenssens E,Bourette RP</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri May 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25567291"> <div itemprop="name">Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation.</div> </a> <div itemprop="about">Stem cells and development</div> <div itemprop="author">Samant MD,Jackson CM,Felix CL,Jones AJ,Goodrich DW,Foster BA,Huss WJ</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri May 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25586771"> <div itemprop="name">Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Sun Z,Zhang C,Zou X,Jiang G,Xu Z,Li W,Xie H</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26278041"> <div itemprop="name">Reprogramming Roadblocks Are System Dependent.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Chantzoura E,Skylaki S,Menendez S,Kim SI,Johnsson A,Linnarsson S,Woltjen K,Chambers I,Kaji K</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 08 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25848763"> <div itemprop="name">Multi-lineage differentiation of human umbilical cord Wharton's Jelly Mesenchymal Stromal Cells mediates changes in the expression profile of stemness markers.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Ali H,Al-Yatama MK,Abu-Farha M,Behbehani K,Al Madhoun A</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Mar 25 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24380384"> <div itemprop="name">Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.</div> </a> <div itemprop="about">Cell transplantation</div> <div itemprop="author">Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Nov 16 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26030404"> <div itemprop="name">A Novel Transgenic Mouse Line for Tracing MicroRNA-155-5p Activity In Vivo.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Phiwpan K,Guo J,Zhang W,Hu T,Boruah BM,Zhang J,Zhou X</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to demonstrate a novel approach for detecting miR expression in specific cell types of interest.</div> <div itemprodp="datePublished">Tue Apr 12 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25956259"> <div itemprop="name">Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model.</div> </a> <div itemprop="about">Stem cell research & therapy</div> <div itemprop="author">Zhou F,Gao S,Wang L,Sun C,Chen L,Yuan P,Zhao H,Yi Y,Qin Y,Dong Z,Cao L,Ren H,Zhu L,Li Q,Lu B,Liang A,Xu GT,Zhu H,Gao Z,Ma J,Xu J,Chen X</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat May 09 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25813085"> <div itemprop="name">Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Lu G,Zhang R,Geng S,Peng L,Jayaraman P,Chen C,Xu F,Yang J,Li Q,Zheng H,Shen K,Wang J,Liu X,Wang W,Zheng Z,Qi CF,Si C,He JC,Liu K,Lira SA,Sikora AG,Li L,Xiong H</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2 macrophages.</div> <div itemprodp="datePublished">Fri Mar 27 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26399548"> <div itemprop="name">Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Lee CL,Castle KD,Moding EJ,Blum JM,Williams N,Luo L,Ma Y,Borst LB,Kim Y,Kirsch DG</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to show that total-body irradiation promotes the expansion of a rare population of thymocytes that express oncogenic Kras(G12D).</div> <div itemprodp="datePublished">Thu Sep 24 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25919570"> <div itemprop="name">MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Lin Y,Liu AY,Fan C,Zheng H,Li Y,Zhang C,Wu S,Yu D,Huang Z,Liu F,Luo Q,Yang CJ,Ouyang G</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate how miR-33b acts as an onco-suppressive microRNA in breast cancer progression by inhibiting the stemness and metastasis of breast cancer cells.</div> <div itemprodp="datePublished">Tue Apr 28 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25101081"> <div itemprop="name">Large T Antigen-Specific Cytotoxic T Cells Protect Against Dendritic Cell Tumors through Perforin-Mediated Mechanisms Independent of CD4 T Cell Help.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Duval A,Fuertes Marraco SA,Schwitter D,Leuenberger L,Acha-Orbea H</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to observe that after transfer into syngeneic C57BL/6 mice, MuTuDC lines were quickly rejected.</div> <div itemprodp="datePublished">Thu Aug 07 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25053428"> <div itemprop="name">Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis.</div> </a> <div itemprop="about">Development (Cambridge, England)</div> <div itemprop="author">Reeh KA,Cardenas KT,Bain VE,Liu Z,Laurent M,Manley NR,Richie ER</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to test the hypothesis that Tbx1 negatively regulates thymic epithelial cell growth and differentiation.</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24677089"> <div itemprop="name">High-frequency vaccine-induced CD8⁺ T cells specific for an epitope naturally processed during infection with Mycobacterium tuberculosis do not confer protection.</div> </a> <div itemprop="about">European journal of immunology</div> <div itemprop="author">Lindenstrøm T,Aagaard C,Christensen D,Agger EM,Andersen P</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study the role of CD8 T cells in resistance to mycobacterial infections.</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24082012"> <div itemprop="name">Differential role of all-trans retinoic acid in promoting the development of CD4+ and CD8+ regulatory T cells.</div> </a> <div itemprop="about">Journal of leukocyte biology</div> <div itemprop="author">Ma J,Liu Y,Li Y,Gu J,Liu J,Tang J,Wang J,Ryffel B,Shen Y,Brand D,Liu Z,Zheng SG</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to determine a protocol for developing different regulatory T cell populations and gain novel insights into clinical cell therapy for patients with autoimmune diseases and those needing organ transplantation.</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24470501"> <div itemprop="name">E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">D'Cruz LM,Stradner MH,Yang CY,Goldrath AW</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the mechanism by which E and Id proteins control the development of invariant NKT sublineages after positive selection.</div> <div itemprodp="datePublished">Sat Mar 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24606204"> <div itemprop="name">Serum- and growth-factor-free three-dimensional culture system supports cartilage tissue formation by promoting collagen synthesis via Sox9-Col2a1 interaction.</div> </a> <div itemprop="about">Tissue engineering. Part A</div> <div itemprop="author">Ahmed N,Iu J,Brown CE,Taylor DW,Kandel RA</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24308870"> <div itemprop="name">Immune selection of tumor cells in TCR β-chain transgenic mice.</div> </a> <div itemprop="about">Journal of immunotoxicology</div> <div itemprop="author">Silaeva YY,Grinenko TS,Vagida MS,Kalinina AA,Khromykh LM,Kazansky DB</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to compare the ability of WT and transgenic, immune-compromised mice to reject EL4 thymoma cells.</div> <div itemprodp="datePublished">Wed Oct 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25691946"> <div itemprop="name">Comparison of human adipose-derived stem cells and chondroitinase ABC transplantation on locomotor recovery in the contusion model of spinal cord injury in rats.</div> </a> <div itemprop="about">Iranian journal of basic medical sciences</div> <div itemprop="author">Sarveazad A,Bakhtiari M,Babahajian A,Janzade A,Fallah A,Moradi F,Soleimani M,Younesi M,Goudarzi F</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to compare the effectiveness of two distinct approaches to treating spinal cord injuries.</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25415267"> <div itemprop="name">Establishment of a murine graft-versus-myeloma model using allogeneic stem cell transplantation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Binsfeld M,Beguin Y,Belle L,Otjacques E,Hannon M,Briquet A,Heusschen R,Drion P,Zilberberg J,Bogen B,Baron F,Caers J</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the anti-myeloma effects of allo-SCT from B10.D2 mice into MHC-matched myeloma-bearing Balb/cJ mice.</div> <div itemprodp="datePublished">Tue Dec 15 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25471937"> <div itemprop="name">SMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma.</div> </a> <div itemprop="about">Molecular cancer</div> <div itemprop="author">Khammanivong A,Gopalakrishnan R,Dickerson EB</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to suggest that SMAD specific E3 ubiquitin protein ligase 1 mediated inhibition of bone morphogenetic protein signalling potentiates the long-term survival of head and neck squamous cell carcinoma cancer stem cells.</div> <div itemprodp="datePublished">Wed Dec 03 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24709423"> <div itemprop="name">Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation.</div> </a> <div itemprop="about">Neoplasia (New York, N.Y.)</div> <div itemprop="author">Zhang S,Chung WC,Wu G,Egan SE,Xu K</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Feb 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25237908"> <div itemprop="name">FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Wei HJ,Nickoloff JA,Chen WH,Liu HY,Lo WC,Chang YT,Yang PC,Wu CW,Williams DF,Gelovani JG,Deng WP</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Oct 15 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25198549"> <div itemprop="name">Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu May 28 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25025233"> <div itemprop="name">Efficacy of imiquimod-based transcutaneous immunization using a nano-dispersed emulsion gel formulation.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Stein P,Gogoll K,Tenzer S,Schild H,Stevanovic S,Langguth P,Radsak MP</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to develop a novel imiquimod formulation with feasible pharmaceutical properties and immunological efficacy.</div> <div itemprodp="datePublished">Wed Oct 14 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24581230"> <div itemprop="name">Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties.</div> </a> <div itemprop="about">Cancer cell international</div> <div itemprop="author">Wu TH,Chou YW,Chiu PH,Tang MJ,Hu CW,Yeh ML</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Mar 03 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25232948"> <div itemprop="name">Sortase A induces Th17-mediated and antibody-independent immunity to heterologous serotypes of group A streptococci.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Fan X,Wang X,Li N,Cui H,Hou B,Gao B,Cleary PP,Wang B</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study the Th17 biased antibody-independent immunity to group A streptococci cross-serotype protection.</div> <div itemprodp="datePublished">Mon Jun 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26344747"> <div itemprop="name">Gene Expression Driven by a Strong Viral Promoter in MVA Increases Vaccination Efficiency by Enhancing Antibody Responses and Unmasking CD8⁺ T Cell Epitopes.</div> </a> <div itemprop="about">Vaccines</div> <div itemprop="author">Becker PD,Nörder M,Weissmann S,Ljapoci R,Erfle V,Drexler I,Guzmán CA</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to evaluate the effect of overexpressing recombinant Ag using modified vaccinia virus early/late promoter H5 (mPH5), showing that overexpression enhances antibody responses and increases vaccination efficiency.</div> <div itemprodp="datePublished">Tue Jul 22 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25202011"> <div itemprop="name">Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Tousif S,Singh DK,Ahmad S,Moodley P,Bhattacharyya M,Van Kaer L,Das G</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to show that Isoniazid treatment of Mycobacterium tuberculosis treatment is associated with immune impairment.</div> <div itemprodp="datePublished">Fri Oct 31 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23728301"> <div itemprop="name">High-resolution analysis with novel cell-surface markers identifies routes to iPS cells.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">O'Malley J,Skylaki S,Iwabuchi KA,Chantzoura E,Ruetz T,Johnsson A,Tomlinson SR,Linnarsson S,Kaji K</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jul 04 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23954132"> <div itemprop="name">Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">McHedlidze T,Waldner M,Zopf S,Walker J,Rankin AL,Schuchmann M,Voehringer D,McKenzie AN,Neurath MF,Pflanz S,Wirtz S</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the role of inflammatory networks in liver fibrosis, showing that it is mediated by interleukin-33-dependent innate lymphoid cells.</div> <div itemprodp="datePublished">Thu Aug 22 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23396050"> <div itemprop="name">miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23354167"> <div itemprop="name">GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Chou J,Lin JH,Brenot A,Kim JW,Provot S,Werb Z</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Feb 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23054398"> <div itemprop="name">Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Ferrari-Amorotti G,Fragliasso V,Esteki R,Prudente Z,Soliera AR,Cattelani S,Manzotti G,Grisendi G,Dominici M,Pieraccioli M,Raschellà G,Chiodoni C,Colombo MP,Calabretta B</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23121557"> <div itemprop="name">Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR.</div> </a> <div itemprop="about">British journal of pharmacology</div> <div itemprop="author">Vinet J,van Zwam M,Dijkstra IM,Brouwer N,van Weering HR,Watts A,Meijer M,Fokkens MR,Kannan V,Verzijl D,Vischer HF,Smit MJ,Leurs R,Biber K,Boddeke HW</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study the role of hCCX-CKR in hCXCR3-induced chemotaxis.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23947835"> <div itemprop="name">Evidence for a multipotent mammary progenitor with pregnancy-specific activity.</div> </a> <div itemprop="about">Breast cancer research : BCR</div> <div itemprop="author">Kaanta AS,Virtanen C,Selfors LM,Brugge JS,Neel BG</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Dec 08 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24068938"> <div itemprop="name">Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Caignard G,Leiva-Torres GA,Leney-Greene M,Charbonneau B,Dumaine A,Fodil-Cornu N,Pyzik M,Cingolani P,Schwartzentruber J,Dupaul-Chicoine J,Guo H,Saleh M,Veillette A,Lathrop M,Blanchette M,Majewski J,Pearson A,Vidal SM</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to identify host factors involved in HSV-1 and herpes simplex encephalitis susceptibility in an in vivo HSV-1 infectious model.</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23255789"> <div itemprop="name">Antioxidant treatment regulates the humoral immune response during acute viral infection.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Crump KE,Langston PK,Rajkarnikar S,Grayson JM</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to show that antioxidant treatment regulates the humoral immune response during acute viral infection.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24025407"> <div itemprop="name">Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells.</div> </a> <div itemprop="about">Endocrine-related cancer</div> <div itemprop="author">Zheng Q,Banaszak L,Fracci S,Basali D,Dunlap SM,Hursting SD,Rich JN,Hjlemeland AB,Vasanji A,Berger NA,Lathia JD,Reizes O</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to explore the role of the leptin receptor in the maintenance of cancer stem cells.</div> <div itemprodp="datePublished">Sun Dec 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23335266"> <div itemprop="name">The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Szabo AZ,Fong S,Yue L,Zhang K,Strachan LR,Scalapino K,Mancianti ML,Ghadially R</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23341289"> <div itemprop="name">Estrogen and progesterone together expand murine endometrial epithelial progenitor cells.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Janzen DM,Cheng D,Schafenacker AM,Paik DY,Goldstein AS,Witte ON,Jaroszewicz A,Pellegrini M,Memarzadeh S</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23620528"> <div itemprop="name">Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signaling.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Moh MC,Lorenzini PA,Gullo C,Schwarz H</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to determine the mechanisms behind the activation of monocytes by reverse signalling through the CD137 ligand.</div> <div itemprodp="datePublished">Thu Aug 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23401595"> <div itemprop="name">Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Mc Guire C,Wieghofer P,Elton L,Muylaert D,Prinz M,Beyaert R,van Loo G</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study the role of MALT1 in the development of experimental autoimmune encephalomyelitis.</div> <div itemprodp="datePublished">Fri Mar 15 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24123687"> <div itemprop="name">Small molecule inhibitor of antigen binding and presentation by HLA-DR2b as a therapeutic strategy for the treatment of multiple sclerosis.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Ji N,Somanaboeina A,Dixit A,Kawamura K,Hayward NJ,Self C,Olson GL,Forsthuber TG</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate how blocking the HLA-DR2b allele with small molecule inhibitors may offer a promising therapeutic strategy for the treatment of multiple sclerosis.</div> <div itemprodp="datePublished">Fri Nov 15 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23319738"> <div itemprop="name">Prolonged apoptotic cell accumulation in germinal centers of Mer-deficient mice causes elevated B cell and CD4+ Th cell responses leading to autoantibody production.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Khan TN,Wong EB,Soni C,Rahman ZS</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study the effect of Mer receptor tyrosine kinase deficiency on the clearance of apoptotic cells.</div> <div itemprodp="datePublished">Fri Feb 15 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23727003"> <div itemprop="name">Deciphering the protective role of adaptive immunity to CHIKV/IRES a novel candidate vaccine against Chikungunya in the A129 mouse model.</div> </a> <div itemprop="about">Vaccine</div> <div itemprop="author">Chu H,Das SC,Fuchs JF,Suresh M,Weaver SC,Stinchcomb DT,Partidos CD,Osorio JE</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to demonstrate the immunogenic potential of the CHIKV/IRES vaccine, and to highlight the importance of the role that neutralizing antibodies play in protection against acute Chikungunya viral infection.</div> <div itemprodp="datePublished">Thu Jul 18 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23484127"> <div itemprop="name">Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity.</div> </a> <div itemprop="about">BioMed research international</div> <div itemprop="author">Roehrich ME,Spicher A,Milano G,Vassalli G</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the presence of cardiac-resident progenitor cells with high aldehyde dehydrogenase activity isolated from mouse hearts.</div> <div itemprodp="datePublished">Tue Sep 03 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23288320"> <div itemprop="name">Directed differentiation of human pluripotent cells to neural crest stem cells.</div> </a> <div itemprop="about">Nature protocols</div> <div itemprop="author">Menendez L,Kulik MJ,Page AT,Park SS,Lauderdale JD,Cunningham ML,Dalton S</div> <div itemprop="description">17-0441-82 was used in Flow cytometry/Cell sorting to describes how to perform a highly efficient, lineage-specific differentiation of human pluripotent cells to a NCSC fate.</div> <div itemprodp="datePublished">Tue Jan 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23799994"> <div itemprop="name">Increased invasion and tumorigenicity capacity of CD44+/CD24- breast cancer MCF7 cells in vitro and in nude mice.</div> </a> <div itemprop="about">Cancer cell international</div> <div itemprop="author">Yan W,Chen Y,Yao Y,Zhang H,Wang T</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jun 24 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23593475"> <div itemprop="name">Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Wu S,Ju GQ,Du T,Zhu YJ,Liu GH</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Oct 22 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24279871"> <div itemprop="name">G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses.</div> </a> <div itemprop="about">Journal of hematology & oncology</div> <div itemprop="author">Rubinstein MP,Salem ML,Doedens AL,Moore CJ,Chiuzan C,Rivell GL,Cole DJ,Goldrath AW</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to evaluate whether the biological activity of G-CSF can be improved by pre-association with anti-G-CSF monoclonal antibodies prior to injection.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23555767"> <div itemprop="name">Surveillance on the status of immune cells after Echinnococcus granulosus protoscoleces infection in Balb/c mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Pan W,Zhou HJ,Shen YJ,Wang Y,Xu YX,Hu Y,Jiang YY,Yuan ZY,Ugwu CE,Cao JP</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the systemic immune status of innate and adaptive immunity at 30, 180, 360 days post-infection in mice infected with E. granulousus.</div> <div itemprodp="datePublished">Tue Jan 07 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22464170"> <div itemprop="name">Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Valdez PA,Vithayathil PJ,Janelsins BM,Shaffer AL,Williamson PR,Datta SK</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study the effect of prostaglandin E2 on the function of Th17 cells during differentiation.</div> <div itemprodp="datePublished">Fri Apr 20 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22108823"> <div itemprop="name">Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy.</div> </a> <div itemprop="about">Cancer research</div> <div itemprop="author">Waitz R,Solomon SB,Petre EN,Trumble AE,Fassò M,Norton L,Allison JP</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to demonstrate a novel combination therapy for the augmentation of antitumour immunity and metastatic rejection.</div> <div itemprodp="datePublished">Sun Jan 15 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22553324"> <div itemprop="name">Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Garidou L,Heydari S,Gossa S,McGavern DB</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to assess transforming growth factor beta inhibition as a viable approach to control a persistent viral infection.</div> <div itemprodp="datePublished">Sun Jul 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22438562"> <div itemprop="name">Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Seedhom MO,Mathurin KS,Kim SK,Welsh RM</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22911892"> <div itemprop="name">Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Paik DY,Janzen DM,Schafenacker AM,Velasco VS,Shung MS,Cheng D,Huang J,Witte ON,Memarzadeh S</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Nov 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23144494"> <div itemprop="name">The lupus-prone NZM2410/NZW strain-derived Sle1b sublocus alters the germinal center checkpoint in female mice in a B cell-intrinsic manner.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Wong EB,Khan TN,Mohan C,Rahman ZS</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to show that the effect of Sle1b on Spt-GC, follicular Th cell, and autoantibody responses in B6.Sle1b mice was B cell autonomous.</div> <div itemprodp="datePublished">Sat Dec 15 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23118219"> <div itemprop="name">The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Yang C,Cao M,Liu H,He Y,Xu J,Du Y,Liu Y,Wang W,Cui L,Hu J,Gao F</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 14 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23118219"> <div itemprop="name">The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.</div> </a> <div itemprop="about">The Journal of biological chemistry</div> <div itemprop="author">Yang C,Cao M,Liu H,He Y,Xu J,Du Y,Liu Y,Wang W,Cui L,Hu J,Gao F</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 14 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23166734"> <div itemprop="name">CD95 is part of a let-7/p53/miR-34 regulatory network.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Hau A,Ceppi P,Peter ME</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to identify a novel regulatory network comprising p53, CD95, let-7, and miR-34a that affects cancer cell survival, differentiation, and sensitivity to apoptotic signals.</div> <div itemprodp="datePublished">Thu Jun 20 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21419662"> <div itemprop="name">RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the contribution of NF-κB to IL-17 production by T cells, showing that RelA and RelB in distinct thymocyte populations control lymphotoxin-dependent IL-17 production.</div> <div itemprodp="datePublished">Fri Mar 25 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21946417"> <div itemprop="name">Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Monticelli LA,Sonnenberg GF,Abt MC,Alenghat T,Ziegler CG,Doering TA,Angelosanto JM,Laidlaw BJ,Yang CY,Sathaliyawala T,Kubota M,Turner D,Diamond JM,Goldrath AW,Farber DL,Collman RG,Wherry EJ,Artis D</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after viral replication.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22057289"> <div itemprop="name">The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Yang CY,Best JA,Knell J,Yang E,Sheridan AD,Jesionek AK,Li HS,Rivera RR,Lind KC,D'Cruz LM,Watowich SS,Murre C,Goldrath AW</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to elucidate the mechanisms of regulation of terminal differentiation of CD8(+) T cells.</div> <div itemprodp="datePublished">Sun Nov 06 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21677778"> <div itemprop="name">Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Serre K,Bénézech C,Desanti G,Bobat S,Toellner KM,Bird R,Chan S,Kastner P,Cunningham AF,Maclennan IC,Mohr E</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to reveal the selective upregulation of Helios during Th2 and TFh responses to alum-protein vaccines.</div> <div itemprodp="datePublished">Mon Oct 17 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21788404"> <div itemprop="name">Online nanoflow multidimensional fractionation for high efficiency phosphopeptide analysis.</div> </a> <div itemprop="about">Molecular & cellular proteomics : MCP</div> <div itemprop="author">Ficarro SB,Zhang Y,Carrasco-Alfonso MJ,Garg B,Adelmant G,Webber JT,Luckey CJ,Marto JA</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to explore two novel multidimensional fractionation strategies for the gathering of phosphoproteomics data.</div> <div itemprodp="datePublished">Tue Nov 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21633508"> <div itemprop="name">GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Nadendla SK,Hazan A,Ward M,Harper LJ,Moutasim K,Bianchi LS,Naase M,Ghali L,Thomas GJ,Prowse DM,Philpott MP,Neill GW</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Sep 30 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20978352"> <div itemprop="name">Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Flutter B,Edwards N,Fallah-Arani F,Henderson S,Chai JG,Sivakumaran S,Ghorashian S,Bennett CL,Freeman GJ,Sykes M,Chakraverty R</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to explore the role of recipient antigen expression by nonhaematopoietic cells in the failure to sustain effective cytotoxic T lymphocyte immunity following blood transplantation.</div> <div itemprodp="datePublished">Mon Nov 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20335267"> <div itemprop="name">Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Nakamura R,Maeda N,Shibata K,Yamada H,Kase T,Yoshikai Y</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to determine why interleukin-15 knockout mice exhibit reduced mortality after infection with influenza virus A.</div> <div itemprodp="datePublished">Tue Jun 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20354143"> <div itemprop="name">The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Pastorino S,Renganathan H,Caliva MJ,Filbert EL,Opoku-Ansah J,Sulzmaier FJ,Gawecka JE,Werlen G,Shaw AS,Ramos JW</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the physiological function of PEA-15, showing that it negatively regulates T-cell receptor signalling.</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20083667"> <div itemprop="name">Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Jones GW,McLoughlin RM,Hammond VJ,Parker CR,Williams JD,Malhotra R,Scheller J,Williams AS,Rose-John S,Topley N,Jones SA</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to report that local control of IL-6 trans signalling regulates the effector characteristics of the T cell infiltrate and promotes the maintenance of IL-17A-secreting CD4(+) T cells.</div> <div itemprodp="datePublished">Mon Feb 15 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20483720"> <div itemprop="name">Increased hematopoietic cells in the mertk-/- mouse peritoneal cavity: a result of augmented migration.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Williams JC,Wagner NJ,Earp HS,Vilen BJ,Matsushima GK</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study increased hematopoietic cells in the mertk-/- mouse peritoneal cavity as a result of augmented migration.</div> <div itemprodp="datePublished">Tue Jun 15 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19139167"> <div itemprop="name">Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Gräbner R,Lötzer K,Döpping S,Hildner M,Radke D,Beer M,Spanbroek R,Lippert B,Reardon CA,Getz GS,Fu YX,Hehlgans T,Mebius RE,van der Wall M,Kruspe D,Englert C,Lovas A,Hu D,Randolph GJ,Weih F,Habenicht AJ</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate how the LTbetaR pathway has a major role in shaping the immunological characteristics and overall integrity of the arterial wall.</div> <div itemprodp="datePublished">Fri Jan 16 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19834548"> <div itemprop="name">Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Kemball CC,Harkins S,Whitmire JK,Flynn CT,Feuer R,Whitton JL</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to evaluate in vitro and in vivo antigen presentation by coxsackievirus B3, showing that it inhibits antigen presentation in vivo.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19342665"> <div itemprop="name">A protective role for dengue virus-specific CD8+ T cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Yauch LE,Zellweger RM,Kotturi MF,Qutubuddin A,Sidney J,Peters B,Prestwood TR,Sette A,Shresta S</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the role of CD8+ T-cells in the immune response to primary dengue virus infection.</div> <div itemprodp="datePublished">Wed Apr 15 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19917700"> <div itemprop="name">Dendritic cells matured by inflammation induce CD86-dependent priming of naive CD8+ T cells in the absence of their cognate peptide antigen.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Maroof A,Beattie L,Kirby A,Coles M,Kaye PM</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study how inflammation-matured DCs can induce Ag-independent T cell proliferation.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19179413"> <div itemprop="name">Multiple mechanisms contribute to the robust rapid gamma interferon response by CD8+ T cells during Listeria monocytogenes infection.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Bou Ghanem EN,McElroy DS,D'Orazio SE</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to demonstrate the numerous pathways leading to the secretion of IFN-gamma by CD8+ T cells during infection.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19127288"> <div itemprop="name">Two host factors regulate persistence of H7-specific T cells injected in tumor-bearing mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Meunier MC,Baron C,Perreault C</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Feb 13 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19946473"> <div itemprop="name">Effects of Culturing on the Stability of the Putative Murine Adipose Derived Stem Cells Markers.</div> </a> <div itemprop="about">The open stem cell journal</div> <div itemprop="author">Maddox JR,Liao X,Li F,Niyibizi C</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jan 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18689546"> <div itemprop="name">IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18941202"> <div itemprop="name">Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Sahu N,Venegas AM,Jankovic D,Mitzner W,Gomez-Rodriguez J,Cannons JL,Sommers C,Love P,Sher A,Schwartzberg PL,August A</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to determine that Itk and Txk exert their effects on Th cell differentiation/function at the level of expression.</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17698590"> <div itemprop="name">Presenilins regulate alphabeta T cell development by modulating TCR signaling.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Laky K,Fowlkes BJ</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to suggest a model in which PS-dependent Notch signalling influences positive selection and the development of alphabeta T cells by modifying TCR signal transduction.</div> <div itemprodp="datePublished">Mon Sep 03 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17296758"> <div itemprop="name">Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Anis MM,Fulton SA,Reba SM,Harding CV,Boom WH</div> <div itemprop="description">Published figure using CD44 monoclonal antibody (Product # 17-0441-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 01 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16357323"> <div itemprop="name">T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Matsuda JL,Zhang Q,Ndonye R,Richardson SK,Howell AR,Gapin L</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to identify some of the genetic targets of T-bet during V14i NKT-cell lineage development.</div> <div itemprodp="datePublished">Sat Apr 01 00:00:00 EST 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16801398"> <div itemprop="name">Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Witsch EJ,Cao H,Fukuyama H,Weigert M</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to investigate the structure, specificity, and origin of the induced autoantibodies in chronic graft-versus-host disease, showing that light chain editing generates polyreactive antibodies.</div> <div itemprodp="datePublished">Mon Jul 10 00:00:00 EDT 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16818671"> <div itemprop="name">A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Boyman O,Cho JH,Tan JT,Surh CD,Sprent J</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study MHC class 1 control of memory phenotype CD8+ cells.</div> <div itemprodp="datePublished">Mon Jul 10 00:00:00 EDT 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16717190"> <div itemprop="name">Thymic output in aged mice.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Hale JS,Boursalian TE,Turk GL,Fink PJ</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to analyse the function and population dynamics of newly emigrated T-cells in aged mice.</div> <div itemprodp="datePublished">Tue May 30 00:00:00 EDT 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16855047"> <div itemprop="name">Direct stimulation of T cells by membrane vesicles from antigen-presenting cells.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Kovar M,Boyman O,Shen X,Hwang I,Kohler R,Sprent J</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study how dissociated cell membrane fragments from a DC line can be used as an effective substitute for viable DC.</div> <div itemprodp="datePublished">Tue Aug 01 00:00:00 EDT 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17157170"> <div itemprop="name">Distinct roles of IL-7 and stem cell factor in the OP9-DL1 T-cell differentiation culture system.</div> </a> <div itemprop="about">Experimental hematology</div> <div itemprop="author">Wang H,Pierce LJ,Spangrude GJ</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to demonstrate specific roles of SCF, IL-7, and Flt3L in promoting efficient T-lineage differentiation.</div> <div itemprodp="datePublished">Fri Dec 01 00:00:00 EST 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/15833919"> <div itemprop="name">Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.</div> </a> <div itemprop="about">Genes & development</div> <div itemprop="author">Taghon TN,David ES,Zúñiga-Pflücker JC,Rothenberg EV</div> <div itemprop="description">17-0441 was used in Flow cytometry/Cell sorting to study how Notch/Delta signaling is not sufficient for T-lineage specification and commitment, but can be permissive for the maintenance and proliferation of uncommitted progenitors.</div> <div itemprodp="datePublished">Fri Apr 15 00:00:00 EDT 2005</div> </div> </noscript> </div> <div class="border-bottom"></div> <div class="product-bioinformatics-details"> <div class="container"> <h2 class="pdp-sub-heading">Bioinformatics</h2> <div class="row"> <div class="large-span-6 medium-span-12 small-span-12"> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="proteinContent"> <strong>Protein Aliases:</strong> CD44; CD44 antigen; CD44 molecule; CDw44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; Ly-24; Lymphocyte antigen 24; PGP I; PGP-1; PGP-I; PGPI; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; sCD 44; sCD44; soluble CD 44; soluble CD44 </p> <p class="view-buttons" id="ptnViewBtn" ng-class="$ctrl.bioContentLines('proteinContent', 'ptnViewBtn')"> <a id="proteinViewMoreBtn" ng-click="$ctrl.bioContentViewMore('proteinViewMoreBtn', 'proteinViewLessBtn', 'proteinContent')"> View more </a> <a id="proteinViewLessBtn" ng-click="$ctrl.bioContentViewLess('proteinViewLessBtn', 'proteinViewMoreBtn', 'proteinContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="geneContent"> <strong>Gene Aliases:</strong> AU023126; AW121933; AW146109; CD44; CDW44; CSPG8; ECMR-III; HCELL; HERMES; HUTCH-I; IN; LHR; Ly-24; MC56; MDU2; MDU3; MIC4; Pgp-1; Pgp1 </p> <p class="view-buttons" id="geneViewBtn" ng-class="$ctrl.bioContentLines('geneContent', 'geneViewBtn')"> <a id="geneViewMoreBtn" ng-click="$ctrl.bioContentViewMore('geneViewMoreBtn', 'geneViewLessBtn', 'geneContent')"> View more </a> <a id="geneViewLessBtn" ng-click="$ctrl.bioContentViewLess('geneViewLessBtn', 'geneViewMoreBtn', 'geneContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="unitProContent"> <strong>UniProt ID:</strong> <a href="http://www.uniprot.org/uniprot/Q16064" target="_blank">(Human) Q16064</a>, <a href="http://www.uniprot.org/uniprot/P15379" target="_blank">(Mouse) P15379</a> </p> <p class="view-buttons" id="unitViewBtn" ng-class="$ctrl.bioContentLines('unitProContent', 'unitViewBtn')"> <a id="unitProViewMoreBtn" ng-click="$ctrl.bioContentViewMore('unitProViewMoreBtn', 'unitProViewLessBtn', 'unitProContent')"> View more </a> <a id="unitProViewLessBtn" ng-click="$ctrl.bioContentViewLess('unitProViewLessBtn', 'unitProViewMoreBtn', 'unitProContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="entrezContent"> <strong>Entrez Gene ID:</strong> <a href="http://www.ncbi.nlm.nih.gov/gene?term=960" target="_blank">(Human) 960</a>, <a href="http://www.ncbi.nlm.nih.gov/gene?term=12505" target="_blank">(Mouse) 12505</a> </p> <p class="view-buttons" id="etzViewBtn" ng-class="$ctrl.bioContentLines('entrezContent', 'etzViewBtn')"> <a id="entrezViewMoreBtn" ng-click="$ctrl.bioContentViewMore('entrezViewMoreBtn', 'entrezViewLessBtn', 'entrezContent')"> View more </a> <a id="entrezViewLessBtn" ng-click="$ctrl.bioContentViewLess('entrezViewLessBtn', 'entrezViewMoreBtn', 'entrezContent')"> View less </a> </p> </div> </div> <div class="large-span-6 medium-span-12 small-span-12"> <div class="accordion" id="accordion-bioinformatics"> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseOne"> Function(s) </a> </div> <div id="collapseOne" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/cytokine receptor activity"> cytokine receptor activity </a> <a class="icon" href="/antibody/primary/panther/protein binding"> protein binding </a> <a class="icon" href="/antibody/primary/panther/collagen binding"> collagen binding </a> <a class="icon" href="/antibody/primary/panther/hyaluronic acid binding"> hyaluronic acid binding </a> <a class="icon" href="/antibody/primary/panther/hyalurononglucosaminidase activity"> hyalurononglucosaminidase activity </a> <a class="icon" href="/antibody/primary/panther/epidermal growth factor receptor binding"> epidermal growth factor receptor binding </a> <a class="icon" href="/antibody/primary/panther/protein kinase binding"> protein kinase binding </a> <a class="icon" href="/antibody/primary/panther/cytokine binding"> cytokine binding </a> <a class="icon" href="/antibody/primary/panther/phosphoprotein binding"> phosphoprotein binding </a> <a class="icon" href="/antibody/primary/panther/transmembrane signal receptor"> transmembrane signal receptor </a> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseTwo"> Process(es) </a> </div> <div id="collapseTwo" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/cell-matrix adhesion"> cell-matrix adhesion </a> <a class="icon" href="/antibody/primary/panther/single organismal cell-cell adhesion"> single organismal cell-cell adhesion </a> <a class="icon" href="/antibody/primary/panther/extracellular matrix disassembly"> extracellular matrix disassembly </a> <a class="icon" href="/antibody/primary/panther/extracellular matrix organization"> extracellular matrix organization </a> <a class="icon" href="/antibody/primary/panther/hyaluronan catabolic process"> hyaluronan catabolic process </a> <a class="icon" href="/antibody/primary/panther/positive regulation of peptidyl-serine phosphorylation"> positive regulation of peptidyl-serine phosphorylation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of heterotypic cell-cell adhesion"> positive regulation of heterotypic cell-cell adhesion </a> <a class="icon" href="/antibody/primary/panther/negative regulation of apoptotic process"> negative regulation of apoptotic process </a> <a class="icon" href="/antibody/primary/panther/negative regulation of cysteine-type endopeptidase activity involved in apoptotic process"> negative regulation of cysteine-type endopeptidase activity involved in apoptotic process </a> <a class="icon" href="/antibody/primary/panther/negative regulation of DNA damage response, signal transduction by p53 class mediator"> negative regulation of DNA damage response, signal transduction by p53 class mediator </a> <a class="icon" href="/antibody/primary/panther/cellular response to fibroblast growth factor stimulus"> cellular response to fibroblast growth factor stimulus </a> <a class="icon" href="/antibody/primary/panther/positive regulation of peptidyl-tyrosine phosphorylation"> positive regulation of peptidyl-tyrosine phosphorylation </a> <a class="icon" href="/antibody/primary/panther/leukocyte migration"> leukocyte migration </a> <a class="icon" href="/antibody/primary/panther/cartilage development"> cartilage development </a> <a class="icon" href="/antibody/primary/panther/interferon-gamma-mediated signaling pathway"> interferon-gamma-mediated signaling pathway </a> <a class="icon" href="/antibody/primary/panther/positive regulation of ERK1 and ERK2 cascade"> positive regulation of ERK1 and ERK2 cascade </a> <a class="icon" href="/antibody/primary/panther/monocyte aggregation"> monocyte aggregation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of monocyte aggregation"> positive regulation of monocyte aggregation </a> <a class="icon" href="/antibody/primary/panther/negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"> negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator </a> <a class="icon" href="/antibody/primary/panther/regulation of cell growth"> regulation of cell growth </a> <a class="icon" href="/antibody/primary/panther/branching involved in ureteric bud morphogenesis"> branching involved in ureteric bud morphogenesis </a> <a class="icon" href="/antibody/primary/panther/wound healing involved in inflammatory response"> wound healing involved in inflammatory response </a> <a class="icon" href="/antibody/primary/panther/positive regulation of adaptive immune response"> positive regulation of adaptive immune response </a> <a class="icon" href="/antibody/primary/panther/negative regulation of mature B cell apoptotic process"> negative regulation of mature B cell apoptotic process </a> <a class="icon" href="/antibody/primary/panther/cell adhesion"> cell adhesion </a> <a class="icon" href="/antibody/primary/panther/positive regulation of gene expression"> positive regulation of gene expression </a> <a class="icon" href="/antibody/primary/panther/Wnt signaling pathway"> Wnt signaling pathway </a> <a class="icon" href="/antibody/primary/panther/cell migration"> cell migration </a> <a class="icon" href="/antibody/primary/panther/neuron projection development"> neuron projection development </a> <a class="icon" href="/antibody/primary/panther/positive regulation of neutrophil apoptotic process"> positive regulation of neutrophil apoptotic process </a> <a class="icon" href="/antibody/primary/panther/macrophage fusion"> macrophage fusion </a> <a class="icon" href="/antibody/primary/panther/branching involved in prostate gland morphogenesis"> branching involved in prostate gland morphogenesis </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="recommended-products border-bottom hidden">  It has to be done as per old AB suggested Products section. </div> <script type="text/javascript" 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