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.ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0 > .ubermenu-target.ubermenu-content-align-center{ justify-content:center; } .ubermenu.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0 > .ubermenu-target.ubermenu-content-align-right{ justify-content:flex-end; } /* Force current submenu always open but below others */ .ubermenu-force-current-submenu .ubermenu-item-level-0.ubermenu-current-menu-item > .ubermenu-submenu-drop, .ubermenu-force-current-submenu .ubermenu-item-level-0.ubermenu-current-menu-ancestor > .ubermenu-submenu-drop { display: block!important; opacity: 1!important; visibility: visible!important; margin: 0!important; top: auto!important; height: auto; z-index:19; } /* Invert Horizontal menu to make subs go up */ .ubermenu-invert.ubermenu-horizontal .ubermenu-item-level-0 > .ubermenu-submenu-drop, .ubermenu-invert.ubermenu-horizontal.ubermenu-items-vstretch .ubermenu-item.ubermenu-item-level-0>.ubermenu-submenu-drop{ top:auto; bottom:100%; } .ubermenu-invert.ubermenu-horizontal.ubermenu-sub-indicators .ubermenu-item-level-0.ubermenu-has-submenu-drop > .ubermenu-target > .ubermenu-sub-indicator{ transform:rotate(180deg); } /* Make second level flyouts fly up */ .ubermenu-invert.ubermenu-horizontal .ubermenu-submenu .ubermenu-item.ubermenu-active > .ubermenu-submenu-type-flyout{ top:auto; bottom:0; } /* Clip the submenus properly when inverted */ .ubermenu-invert.ubermenu-horizontal .ubermenu-item-level-0 > .ubermenu-submenu-drop{ clip: rect(-5000px,5000px,auto,-5000px); } /* Invert Vertical menu to make subs go left */ .ubermenu-invert.ubermenu-vertical .ubermenu-item-level-0 > .ubermenu-submenu-drop{ right:100%; left:auto; } .ubermenu-invert.ubermenu-vertical.ubermenu-sub-indicators .ubermenu-item-level-0.ubermenu-item-has-children > .ubermenu-target > .ubermenu-sub-indicator{ right:auto; left:10px; transform:rotate(90deg); } .ubermenu-vertical.ubermenu-invert .ubermenu-item > .ubermenu-submenu-drop { clip: rect(-5000px,5000px,5000px,-5000px); } /* Vertical Flyout > Flyout */ .ubermenu-vertical.ubermenu-invert.ubermenu-sub-indicators .ubermenu-has-submenu-drop > .ubermenu-target{ padding-left:25px; } .ubermenu-vertical.ubermenu-invert .ubermenu-item > .ubermenu-target > .ubermenu-sub-indicator { right:auto; left:10px; transform:rotate(90deg); } .ubermenu-vertical.ubermenu-invert .ubermenu-item > .ubermenu-submenu-drop.ubermenu-submenu-type-flyout, .ubermenu-vertical.ubermenu-invert .ubermenu-submenu-type-flyout > .ubermenu-item > .ubermenu-submenu-drop { right: 100%; left: auto; } .ubermenu-responsive-toggle{ display:none; } } @media screen and (max-width: 1180px){ .ubermenu-responsive-toggle, .ubermenu-sticky-toggle-wrapper { display: block; } .ubermenu-responsive{ width:100%; max-height:600px; visibility:visible; overflow:visible; -webkit-transition:max-height 1s ease-in; transition:max-height .3s ease-in; } .ubermenu-responsive.ubermenu-mobile-accordion:not(.ubermenu-mobile-modal):not(.ubermenu-in-transition):not(.ubermenu-responsive-collapse){ max-height:none; } .ubermenu-responsive.ubermenu-items-align-center{ text-align:left; } .ubermenu-responsive.ubermenu{ margin:0; } .ubermenu-responsive.ubermenu .ubermenu-nav{ display:block; } .ubermenu-responsive.ubermenu-responsive-nocollapse, .ubermenu-repsonsive.ubermenu-no-transitions{ display:block; max-height:none; } .ubermenu-responsive.ubermenu-responsive-collapse{ max-height:none; visibility:visible; overflow:visible; } .ubermenu-responsive.ubermenu-responsive-collapse{ max-height:0; overflow:hidden !important; visibility:hidden; } .ubermenu-responsive.ubermenu-in-transition, .ubermenu-responsive.ubermenu-in-transition .ubermenu-nav{ overflow:hidden !important; visibility:visible; } .ubermenu-responsive.ubermenu-responsive-collapse:not(.ubermenu-in-transition){ border-top-width:0; border-bottom-width:0; } .ubermenu-responsive.ubermenu-responsive-collapse .ubermenu-item .ubermenu-submenu{ display:none; } .ubermenu-responsive .ubermenu-item-level-0{ width:50%; } .ubermenu-responsive.ubermenu-responsive-single-column .ubermenu-item-level-0{ float:none; clear:both; width:100%; } .ubermenu-responsive .ubermenu-item.ubermenu-item-level-0 > .ubermenu-target{ border:none; box-shadow:none; } .ubermenu-responsive .ubermenu-item.ubermenu-has-submenu-flyout{ position:static; } .ubermenu-responsive.ubermenu-sub-indicators .ubermenu-submenu-type-flyout .ubermenu-has-submenu-drop > .ubermenu-target > .ubermenu-sub-indicator{ transform:rotate(0); right:10px; left:auto; } .ubermenu-responsive .ubermenu-nav .ubermenu-item .ubermenu-submenu.ubermenu-submenu-drop{ width:100%; min-width:100%; max-width:100%; top:auto; left:0 !important; } .ubermenu-responsive.ubermenu-has-border .ubermenu-nav .ubermenu-item .ubermenu-submenu.ubermenu-submenu-drop{ left: -1px !important; /* For borders */ } .ubermenu-responsive .ubermenu-submenu.ubermenu-submenu-type-mega > .ubermenu-item.ubermenu-column{ min-height:0; border-left:none; float:left; /* override left/center/right content alignment */ display:block; } .ubermenu-responsive .ubermenu-item.ubermenu-active > .ubermenu-submenu.ubermenu-submenu-type-mega{ max-height:none; height:auto;/*prevent overflow scrolling since android is still finicky*/ overflow:visible; } .ubermenu-responsive.ubermenu-transition-slide .ubermenu-item.ubermenu-in-transition > .ubermenu-submenu-drop{ max-height:1000px; /* because of slide transition */ } .ubermenu .ubermenu-submenu-type-flyout .ubermenu-submenu-type-mega{ min-height:0; } .ubermenu.ubermenu-responsive .ubermenu-column, .ubermenu.ubermenu-responsive .ubermenu-column-auto{ min-width:50%; } .ubermenu.ubermenu-responsive .ubermenu-autoclear > .ubermenu-column{ clear:none; } .ubermenu.ubermenu-responsive .ubermenu-column:nth-of-type(2n+1){ clear:both; } .ubermenu.ubermenu-responsive .ubermenu-submenu-retractor-top:not(.ubermenu-submenu-retractor-top-2) .ubermenu-column:nth-of-type(2n+1){ clear:none; } .ubermenu.ubermenu-responsive .ubermenu-submenu-retractor-top:not(.ubermenu-submenu-retractor-top-2) .ubermenu-column:nth-of-type(2n+2){ clear:both; } .ubermenu-responsive-single-column-subs .ubermenu-submenu .ubermenu-item { float: none; clear: both; width: 100%; min-width: 100%; } .ubermenu.ubermenu-responsive .ubermenu-tabs, .ubermenu.ubermenu-responsive .ubermenu-tabs-group, .ubermenu.ubermenu-responsive .ubermenu-tab, .ubermenu.ubermenu-responsive .ubermenu-tab-content-panel{ /** TABS SHOULD BE 100% ACCORDION */ width:100%; min-width:100%; max-width:100%; left:0; } .ubermenu.ubermenu-responsive .ubermenu-tabs, .ubermenu.ubermenu-responsive .ubermenu-tab-content-panel{ min-height:0 !important;/* Override Inline Style from JS */ } .ubermenu.ubermenu-responsive .ubermenu-tabs{ z-index:15; } .ubermenu.ubermenu-responsive .ubermenu-tab-content-panel{ z-index:20; } /* Tab Layering */ .ubermenu-responsive .ubermenu-tab{ position:relative; } .ubermenu-responsive .ubermenu-tab.ubermenu-active{ position:relative; z-index:20; } .ubermenu-responsive .ubermenu-tab > .ubermenu-target{ border-width:0 0 1px 0; } .ubermenu-responsive.ubermenu-sub-indicators .ubermenu-tabs > .ubermenu-tabs-group > .ubermenu-tab.ubermenu-has-submenu-drop > .ubermenu-target > .ubermenu-sub-indicator{ transform:rotate(0); right:10px; left:auto; } .ubermenu-responsive .ubermenu-tabs > .ubermenu-tabs-group > .ubermenu-tab > .ubermenu-tab-content-panel{ top:auto; border-width:1px; } .ubermenu-responsive .ubermenu-tab-layout-bottom > .ubermenu-tabs-group{ /*position:relative;*/ } .ubermenu-reponsive .ubermenu-item-level-0 > .ubermenu-submenu-type-stack{ /* Top Level Stack Columns */ position:relative; } .ubermenu-responsive .ubermenu-submenu-type-stack .ubermenu-column, .ubermenu-responsive .ubermenu-submenu-type-stack .ubermenu-column-auto{ /* Stack Columns */ width:100%; max-width:100%; } .ubermenu-responsive .ubermenu-item-mini{ /* Mini items */ min-width:0; width:auto; float:left; clear:none !important; } .ubermenu-responsive .ubermenu-item.ubermenu-item-mini > a.ubermenu-target{ padding-left:20px; padding-right:20px; } .ubermenu-responsive .ubermenu-item.ubermenu-hide-mobile{ /* Hiding items */ display:none !important; } .ubermenu-responsive.ubermenu-hide-bkgs .ubermenu-submenu.ubermenu-submenu-bkg-img{ /** Hide Background Images in Submenu */ background-image:none; } .ubermenu.ubermenu-responsive .ubermenu-item-level-0.ubermenu-item-mini{ min-width:0; width:auto; } .ubermenu-vertical .ubermenu-item.ubermenu-item-level-0{ width:100%; } .ubermenu-vertical.ubermenu-sub-indicators .ubermenu-item-level-0.ubermenu-item-has-children > .ubermenu-target > .ubermenu-sub-indicator{ right:10px; left:auto; transform:rotate(0); } .ubermenu-vertical .ubermenu-item.ubermenu-item-level-0.ubermenu-relative.ubermenu-active > .ubermenu-submenu-drop.ubermenu-submenu-align-vertical_parent_item{ top:auto; } .ubermenu.ubermenu-responsive .ubermenu-tabs{ position:static; } /* Tabs on Mobile with mouse (but not click) - leave space to hover off */ .ubermenu:not(.ubermenu-is-mobile):not(.ubermenu-submenu-indicator-closes) .ubermenu-submenu .ubermenu-tab[data-ubermenu-trigger="mouseover"] .ubermenu-tab-content-panel, .ubermenu:not(.ubermenu-is-mobile):not(.ubermenu-submenu-indicator-closes) .ubermenu-submenu .ubermenu-tab[data-ubermenu-trigger="hover_intent"] .ubermenu-tab-content-panel{ margin-left:6%; width:94%; min-width:94%; } /* Sub indicator close visibility */ .ubermenu.ubermenu-submenu-indicator-closes .ubermenu-active > .ubermenu-target > .ubermenu-sub-indicator-close{ display:block; display: flex; align-items: center; justify-content: center; } .ubermenu.ubermenu-submenu-indicator-closes .ubermenu-active > .ubermenu-target > .ubermenu-sub-indicator{ display:none; } .ubermenu .ubermenu-tabs .ubermenu-tab-content-panel{ box-shadow: 0 5px 10px rgba(0,0,0,.075); } /* When submenus and items go full width, move items back to appropriate positioning */ .ubermenu .ubermenu-submenu-rtl { direction: ltr; } /* Fixed position mobile menu */ .ubermenu.ubermenu-mobile-modal{ position:fixed; z-index:9999999; opacity:1; top:0; left:0; width:100%; width:100vw; max-width:100%; max-width:100vw; height:100%; height:calc(100vh - calc(100vh - 100%)); height:-webkit-fill-available; max-height:calc(100vh - calc(100vh - 100%)); max-height:-webkit-fill-available; border:none; box-sizing:border-box; display:flex; flex-direction:column; justify-content:flex-start; overflow-y:auto !important; /* for non-accordion mode */ overflow-x:hidden !important; overscroll-behavior: contain; transform:scale(1); transition-duration:.1s; transition-property: all; } .ubermenu.ubermenu-mobile-modal.ubermenu-mobile-accordion.ubermenu-interaction-press{ overflow-y:hidden !important; } .ubermenu.ubermenu-mobile-modal.ubermenu-responsive-collapse{ overflow:hidden !important; opacity:0; transform:scale(.9); visibility:hidden; } .ubermenu.ubermenu-mobile-modal .ubermenu-nav{ flex:1; overflow-y:auto !important; overscroll-behavior: contain; } .ubermenu.ubermenu-mobile-modal .ubermenu-item-level-0{ margin:0; } .ubermenu.ubermenu-mobile-modal .ubermenu-mobile-close-button{ border:none; background:none; border-radius:0; padding:1em; color:inherit; display:inline-block; text-align:center; font-size:14px; } .ubermenu.ubermenu-mobile-modal .ubermenu-mobile-footer .ubermenu-mobile-close-button{ width: 100%; display: flex; align-items: center; justify-content: center; } .ubermenu.ubermenu-mobile-modal .ubermenu-mobile-footer .ubermenu-mobile-close-button .ubermenu-icon-essential, .ubermenu.ubermenu-mobile-modal .ubermenu-mobile-footer .ubermenu-mobile-close-button .fas.fa-times{ margin-right:.2em; } /* Header/Footer Mobile content */ .ubermenu .ubermenu-mobile-header, .ubermenu .ubermenu-mobile-footer{ display:block; text-align:center; color:inherit; } /* Accordion submenus mobile (single column tablet) */ .ubermenu.ubermenu-responsive-single-column.ubermenu-mobile-accordion.ubermenu-interaction-press .ubermenu-item > .ubermenu-submenu-drop, .ubermenu.ubermenu-responsive-single-column.ubermenu-mobile-accordion.ubermenu-interaction-press .ubermenu-tab > .ubermenu-tab-content-panel{ box-sizing:border-box; border-left:none; border-right:none; box-shadow:none; } .ubermenu.ubermenu-responsive-single-column.ubermenu-mobile-accordion.ubermenu-interaction-press .ubermenu-item.ubermenu-active > .ubermenu-submenu-drop, .ubermenu.ubermenu-responsive-single-column.ubermenu-mobile-accordion.ubermenu-interaction-press .ubermenu-tab.ubermenu-active > .ubermenu-tab-content-panel{ position:static; } /* Accordion indented - remove borders and extra spacing from headers */ .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu.ubermenu-submenu-drop, .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu .ubermenu-item-header.ubermenu-has-submenu-stack > .ubermenu-target{ border:none; } .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu .ubermenu-item-header.ubermenu-has-submenu-stack > .ubermenu-submenu-type-stack{ padding-top:0; } /* Accordion dropdown indentation padding */ .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-item > .ubermenu-target, .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-tab-content-panel .ubermenu-item > .ubermenu-target{ padding-left:calc( var(--ubermenu-accordion-indent) * 2 ); } .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-item > .ubermenu-target, .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-tab-content-panel .ubermenu-tab-content-panel .ubermenu-item > .ubermenu-target{ padding-left:calc( var(--ubermenu-accordion-indent) * 3 ); } .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-item > .ubermenu-target, .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-tab-content-panel .ubermenu-tab-content-panel .ubermenu-tab-content-panel .ubermenu-item > .ubermenu-target{ padding-left:calc( var(--ubermenu-accordion-indent) * 4 ); } /* Reverse Accordion dropdown indentation padding */ .rtl .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-item > .ubermenu-target, .rtl .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-tab-content-panel .ubermenu-item > .ubermenu-target{ padding-left:0; padding-right:calc( var(--ubermenu-accordion-indent) * 2 ); } .rtl .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-item > .ubermenu-target, .rtl .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-tab-content-panel .ubermenu-tab-content-panel .ubermenu-item > .ubermenu-target{ padding-left:0; padding-right:calc( var(--ubermenu-accordion-indent) * 3 ); } .rtl .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-submenu-drop .ubermenu-item > .ubermenu-target, .rtl .ubermenu.ubermenu-mobile-accordion-indent .ubermenu-submenu-drop .ubermenu-tab-content-panel .ubermenu-tab-content-panel .ubermenu-tab-content-panel .ubermenu-item > .ubermenu-target{ padding-left:0; padding-right:calc( var(--ubermenu-accordion-indent) * 4 ); } .ubermenu-responsive-toggle{ display:block; } } @media screen and (max-width: 480px){ .ubermenu.ubermenu-responsive .ubermenu-item-level-0{ width:100%; } .ubermenu.ubermenu-responsive .ubermenu-column, .ubermenu.ubermenu-responsive .ubermenu-column-auto{ min-width:100%; } .ubermenu 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3 November 2022 | <a href="https://www.drugtargetreview.com/content_author/izzy-wood-drug-target-review/" rel="tag">Izzy Wood (Drug Target Review)</a> | <a href="https://www.drugtargetreview.com/news/106183/pre-clinical-model-of-appendiceal-cancer-developed/#respond" class="comments-link" >No comments yet</a></p> </div> <div class="excerpt"><p>Researchers from the University of California have developed the first pre-clinical model of appendiceal cancer, containing all elements of the tumour. </p> </div> <div class="articleImage"> <img data-lazyloaded="1" src="data:image/gif;base64,R0lGODdhAQABAPAAAMPDwwAAACwAAAAAAQABAAACAkQBADs=" width="750" height="450" data-src="https://www.drugtargetreview.com/wp-content/uploads/appendiceal-cancer.jpg" class="attachment-large-rectangle size-large-rectangle wp-post-image" alt="appendiceal cancer" decoding="async" fetchpriority="high" data-srcset="https://www.drugtargetreview.com/wp-content/uploads/appendiceal-cancer.jpg 750w, https://www.drugtargetreview.com/wp-content/uploads/appendiceal-cancer-375x225.jpg 375w" data-sizes="(max-width: 750px) 100vw, 750px" /><noscript><img width="750" height="450" src="https://www.drugtargetreview.com/wp-content/uploads/appendiceal-cancer.jpg" class="attachment-large-rectangle size-large-rectangle wp-post-image" alt="appendiceal cancer" decoding="async" fetchpriority="high" srcset="https://www.drugtargetreview.com/wp-content/uploads/appendiceal-cancer.jpg 750w, https://www.drugtargetreview.com/wp-content/uploads/appendiceal-cancer-375x225.jpg 375w" sizes="(max-width: 750px) 100vw, 750px" /></noscript></div>   <p>In a paper published in <a href="https://aacrjournals.org/clincancerres" target="_blank" rel="noopener"><em>Clinical Cancer Research</em></a>, researchers at University of California, San Diego School of Medicine and Moores Cancer Centre at UC San Diego Health, both US, described the first <a href="https://www.drugtargetreview.com/news/105864/ground-breaking-3d-bioprinted-tumours-aid-immunotherapy-research/" target="_blank" rel="noopener">pre-clinical model</a> of appendiceal cancer that contains all elements of the tumour.</p> <p>According to the researchers, a primary challenge when attempting to study <a href="https://www.drugtargetreview.com/news/94967/personalised-organoid-models-may-improve-immunotherapy-treatment/" target="_blank" rel="noopener">appendiceal cancer</a> and find remedies has been the lack of an effective pre-clinical model to probe its pathology and test new drugs or therapeutic approaches. The new research has therefore allowed all previously stymied investigations to proceed.</p> <p>Appendiceal cancer is very rare, occurring in perhaps one or two people per million, per year. Prognoses is mixed, with a five-year survival rate of 67 to 97 percent for low-grade tumours detected early, but much lower for advanced cases that may have spread to other parts of the body.</p><div class="drugt-41ac5e842bd9775063f871fdbccce446 drugt-content" id="drugt-41ac5e842bd9775063f871fdbccce446"></div> <p>The obstacles to creating a pre-clinical model of appendiceal cancer are numerous:</p> <ul> <li>Access to clinical tissues is rare because the disease is rare</li> <li>The majority of neoplasms have mucinous histology, a characteristic that makes them difficult to assess under a microscope and to culture</li> <li>Mice do not have the equivalent of a human appendix, rendering them unsuitable as a genetically modified model. </li> </ul> <p>Dr Andrew Lowy, senior author and chief of the Division of Surgical Oncology at Moores Cancer Centre, and colleagues, developed an organotypic slice culture of living appendiceal <a href="https://www.drugtargetreview.com/news/104755/combining-immunotherapy-and-virotherapy-shows-promise-for-treatment-resistant-cancers/" target="_blank" rel="noopener">cancer cells</a>.</p> <p>Organotypic slices are three-dimensional cultures of an organ. In this case, the slices are made from appendiceal cancer tissue removed from patients at surgery, then cultured <em>ex vivo</em> of the patient. Organotypic slices have been created to model other cancers, such as pancreatic, lung and colon, but not appendiceal, until now. </p> <p>“We have learned that appendiceal cancer has a distinctive genomic landscape and is surprisingly full of immune cells,” said Lowy. ”Relying on other models, such as colorectal, does not apply, which makes this an unmet need. Epithelial neoplasms of the appendix are rare, but without an effective way to study them, the opportunities to develop new treatments have also been rare.”</p> <p>The authors explained that the organotypic model accurately recapitulates appendiceal tumours in terms of cell mix and behaviour, which makes it a promising new research tool in addition to other approaches, such as organoids and patient-derived xenografts (transplanted tissue grown in another species, such as a mouse or rat).</p> <p>“We have learned that utilising tissue slices made from patient tumour resections is great way to study the pathobiology of this disease and we are hopeful they will help predict therapy responses in patients,” added Lowy. “Using this new model, we can now test new treatments that might lead to better outcomes for patients with advanced disease.”</p> <div id="taxos2"> <div class="terms"><p>Related topics<br /><a href="https://www.drugtargetreview.com/topic/cell-culture/" rel="tag">Cell Cultures</a>, <a href="https://www.drugtargetreview.com/topic/genomics/" rel="tag">Genomics</a>, <a href="https://www.drugtargetreview.com/topic/organoids/" rel="tag">Organoids</a>, <a href="https://www.drugtargetreview.com/topic/targets/" rel="tag">Targets</a></p></div> <div class="terms"><p>Related conditions<br /><a href="https://www.drugtargetreview.com/condition/appendiceal-cancer/" rel="tag">appendiceal cancer</a></p></div> <div class="terms"><p>Related organisations<br /><a href="https://www.drugtargetreview.com/organisations/university-of-california/" rel="tag">California University</a></p></div> <div class="terms"><p>Related people<br /><a href="https://www.drugtargetreview.com/people/dr-andrew-lowy/" rel="tag">Dr Andrew Lowy</a></p></div></div> </article>    <div id="sidebarFallback1" class="bodyMpu"> <div id="group3"> <div class="randomordercontent group3">  <div id="ad20"></div> <script data-cfasync="false" 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