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href="//files.rcsb.org/download/4XIW.pdb.gz">Legacy PDB Format (gz)</a></li><li class="filedivider"></li><li><a href="//files.rcsb.org/download/4XIW.xml.gz">PDBML/XML Format (gz)</a></li><li class="filedivider"></li><li><a href="//files.rcsb.org/download/4XIW-sf.cif">Structure Factors (CIF)</a></li><li><a href="//files.rcsb.org/download/4XIW-sf.cif.gz">Structure Factors (CIF - gz)</a></li><li class="filedivider"></li><li><a target="_blank" rel="noopener" href="//files.rcsb.org/pub/pdb/validation_reports/xi/4xiw/4xiw_full_validation.pdf">Validation Full PDF</a></li><li><a target="_blank" rel="noopener" href="//files.rcsb.org/pub/pdb/validation_reports/xi/4xiw/4xiw_validation.xml.gz">Validation (XML - gz)</a></li><li><a target="_blank" rel="noopener" href="//files.rcsb.org/pub/pdb/validation_reports/xi/4xiw/4xiw_validation.cif.gz">Validation (CIF - gz)</a></li><li><a target="_blank" rel="noopener" href="//files.rcsb.org/pub/pdb/validation_reports/xi/4xiw/4xiw_validation_2fo-fc_map_coef.cif.gz">Validation 2fo-fc coefficients (CIF - gz)</a></li><li><a target="_blank" rel="noopener" href="//files.rcsb.org/pub/pdb/validation_reports/xi/4xiw/4xiw_validation_fo-fc_map_coef.cif.gz">Validation fo-fc coefficients (CIF - gz)</a></li><li class="filedivider"></li><li><a href="//files.rcsb.org/download/4XIW-assembly1.cif.gz">Biological Assembly 1 (CIF - gz) <span class="fa fa-info-circle" aria-hidden="true" data-toggle="tooltip" data-placement="top" title="Biological assembly files in .cif format."></span></a></li><li><a href="//files.rcsb.org/download/4XIW-assembly2.cif.gz">Biological Assembly 2 (CIF - gz) </a></li><li><a href="//files.rcsb.org/download/4XIW-assembly3.cif.gz">Biological Assembly 3 (CIF - gz) </a></li><li><a href="//files.rcsb.org/download/4XIW-assembly4.cif.gz">Biological Assembly 4 (CIF - gz) </a></li><li><a href="//files.rcsb.org/download/4XIW.pdb1.gz">Biological Assembly 1 (PDB - gz)</a></li><li><a href="//files.rcsb.org/download/4XIW.pdb2.gz">Biological Assembly 2 (PDB - gz)</a></li><li><a href="//files.rcsb.org/download/4XIW.pdb3.gz">Biological Assembly 3 (PDB - gz)</a></li><li><a href="//files.rcsb.org/download/4XIW.pdb4.gz">Biological Assembly 4 (PDB - gz)</a></li></ul></div></div><div class="btn-group" role="group" style="margin-left: 2px;" target="_blank" data-toggle="tooltip" data-placement="top" data-original-title="Get the Data API query used to generate this page"> <a 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%0A%20%20%20%20%20%20rcsb_nonpolymer_entity%20%7B%0A%20%20%20%20%20%20%20%20pdbx_description%0A%20%20%20%20%20%20%7D%0A%20%20%20%20%20%20nonpolymer_comp%20%7B%0A%20%20%20%20%20%20%20%20chem_comp%20%7B%0A%20%20%20%20%20%20%20%20%20%20id%0A%20%20%20%20%20%20%20%20%20%20formula_weight%0A%20%20%20%20%20%20%20%20%20%20name%0A%20%20%20%20%20%20%20%20%20%20formula%0A%20%20%20%20%20%20%20%20%7D%0A%20%20%20%20%20%20%20%20pdbx_reference_molecule%20%7B%0A%20%20%20%20%20%20%20%20%20%20prd_id%0A%20%20%20%20%20%20%20%20%20%20chem_comp_id%0A%20%20%20%20%20%20%20%20%20%20type%0A%20%20%20%20%20%20%20%20%20%20name%0A%20%20%20%20%20%20%20%20%20%20class%0A%20%20%20%20%20%20%20%20%7D%0A%20%20%20%20%20%20%20%20rcsb_chem_comp_descriptor%20%7B%0A%20%20%20%20%20%20%20%20%20%20InChIKey%0A%20%20%20%20%20%20%20%20%7D%0A%20%20%20%20%20%20%7D%0A%20%20%20%20%7D%0A%20%20%20%20assemblies%20%7B%0A%20%20%20%20%20%20rcsb_assembly_container_identifiers%20%7B%0A%20%20%20%20%20%20%20%20assembly_id%0A%20%20%20%20%20%20%7D%0A%20%20%20%20%20%20pdbx_struct_assembly%20%7B%0A%20%20%20%20%20%20%20%20rcsb_details%0A%20%20%20%20%20%20%20%20method_details%0A%20%20%20%20%20%20%20%20rcsb_candidate_assembly%0A%20%20%20%20%20%20%7D%0A%20%20%20%20%20%20pdbx_struct_assembly_auth_evidence%20%7B%0A%20%20%20%20%20%20%20%20experimental_support%0A%20%20%20%20%20%20%7D%0A%20%20%20%20%20%20rcsb_struct_symmetry%20%7B%0A%20%20%20%20%20%20%20%20kind%0A%20%20%20%20%20%20%20%20type%0A%20%20%20%20%20%20%20%20symbol%0A%20%20%20%20%20%20%20%20oligomeric_state%0A%20%20%20%20%20%20%20%20stoichiometry%0A%20%20%20%20%20%20%7D%0A%20%20%20%20%20%20rcsb_assembly_info%20%7B%0A%20%20%20%20%20%20%20%20modeled_polymer_monomer_count%0A%20%20%20%20%20%20%7D%0A%20%20%20%20%7D%0A%20%20%7D%0A%7D&variables=%7B%22id%22%3A%20%224XIW%22%7D"><button class="btn btn-sm btn-default"><span class="glyphicon glyphicon-cog"></span> Data API  </button></a></div></div><h1><style>.id_divider{ color: #ccc; padding: 0 10px 0 10px; } .extended_id_info{ color: #ccc; font-size: 18px; position: relative; top: -10px; left:-5px; }</style><div class="results-content-type experimental"><span class="fa fa-flask" data-toggle="tooltip" data-placement="top" data-original-title="Experimental PDB Structure"></span></div><span id="structureID"> 4XIW </span><span class="id_divider">| </span><span>pdb_00004xiw </span><span class="extended_id_span"><a href="https://www.wwpdb.org/documentation/new-format-for-pdb-ids" target="_blank"><span class="glyphicon glyphicon-info-sign extended_id_info" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Extended PDB ID. Click to learn more"></span></a></span></h1><h4><span id="structureTitle">Carbonic anhydrase Cah3 from Chlamydomonas reinhardtii in complex with acetazolamide </span></h4><ul class="list-inline"><li id="header_doi"><strong>PDB DOI:&nbsp</strong><a href="https://doi.org/10.2210/pdb4XIW/pdb" target="_blank" rel="noopener">https://doi.org/10.2210/pdb4XIW/pdb</a></li></ul><ul class="list-unstyled"><li id="header_classification"><strong>Classification:&nbsp<a href="/search?q=struct_keywords.pdbx_keywords:LYASE" onClick="sendGtag("title_section", "ssp_search_link", "classification")">LYASE</a></strong></li><li id="header_organism"><strong>Organism(s):&nbsp</strong><a href="/search?q=rcsb_entity_source_organism.taxonomy_lineage.name:Chlamydomonas reinhardtii" onClick="sendGtag("title_section", "ssp_search_link", "organism")">Chlamydomonas reinhardtii</a></li><li id="header_expression-system"><strong>Expression System:&nbsp</strong><a href="/search?q=rcsb_entity_host_organism.ncbi_scientific_name:Escherichia coli" onClick="sendGtag("title_section", "ssp_search_link", "expression")">Escherichia coli</a></li><li id="header_mutation"><strong>Mutation(s):&nbsp</strong>No&nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="right" data-original-title="Indicates sequence mutations."></span></li><br><li id="header_deposited-released-dates"><strong>Deposited:&nbsp</strong>2015-01-07&nbsp<strong>Released:&nbsp</strong>2015-02-11&nbsp</li><li id="header_deposition-authors"><strong>Deposition Author(s):&nbsp</strong><a href="/search?q=audit_author.name:Hainzl, T." onClick="sendGtag("title_section", "ssp_search_link", "depAuthor")">Hainzl, T.</a>, <a href="/search?q=audit_author.name:Grundstrom, C." onClick="sendGtag("title_section", "ssp_search_link", "depAuthor")">Grundstrom, C.</a>, <a href="/search?q=audit_author.name:Benlloch, R." onClick="sendGtag("title_section", "ssp_search_link", "depAuthor")">Benlloch, R.</a>, <a href="/search?q=audit_author.name:Shevela, D." onClick="sendGtag("title_section", "ssp_search_link", "depAuthor")">Shevela, D.</a>, <a href="/search?q=audit_author.name:Shutova, T." onClick="sendGtag("title_section", "ssp_search_link", "depAuthor")">Shutova, T.</a>, <a href="/search?q=audit_author.name:Messinger, J." onClick="sendGtag("title_section", "ssp_search_link", "depAuthor")">Messinger, J.</a>, <a href="/search?q=audit_author.name:Samuelsson, G." onClick="sendGtag("title_section", "ssp_search_link", "depAuthor")">Samuelsson, G.</a>, <a href="/search?q=audit_author.name:Sauer-Eriksson, A.E." onClick="sendGtag("title_section", "ssp_search_link", "depAuthor")">Sauer-Eriksson, A.E.</a></li><li id="header_funding-organism"><strong>Funding Organization(s):&nbsp</strong>Swedish Research Council</li></ul><hr><div class="row"><div class="col-sm-5 col-xs-12" id="header_experimentalDataSnapshot"><p><strong>Experimental Data Snapshot</strong></p><ul class="list-unstyled" id="exp_header_0_snapshot"><li id="exp_header_0_method"><strong>Method:&nbsp</strong>X-RAY DIFFRACTION</li><li id="exp_header_0_diffraction_resolution"><strong>Resolution:&nbsp</strong>2.60 Å</li><li id="exp_header_0_diffraction_rvalueFree"><strong>R-Value Free:&nbsp</strong><div> 0.226 (Depositor), 0.230 (DCC)&nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Depositor: R factors reported by the deposition authors. DCC: R factors re-calculated by DCC software using depositor data"></span></div></li><li id="exp_header_0_diffraction_rvalueWork"><strong>R-Value Work:&nbsp</strong><div> 0.161 (Depositor), 0.160 (DCC)&nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Depositor: R factors reported by the deposition authors. DCC: R factors re-calculated by DCC software using depositor data"></span></div></li><li id="exp_header_0_diffraction_rvalueObserved"><strong>R-Value Observed:&nbsp</strong><div>0.164&nbsp(Depositor)&nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="The residual factor for reflections that satisfy the resolution limits and the criterion that classifies a reflection as "observed" (typically expressed in terms of a sigma(I) or sigma(F) threshold). Depositor: R factors reported by the deposition authors"></span></div></li></ul><p> <strong>Starting Model: </strong>experimental<br><a href="/experimental/4XIW#starting-model">View more details</a></p></div><div class="col-sm-7 col-xs-12"><style>div.validation-slider { border: 1px solid #ddd; padding: 5px; } div.validation-slider img { max-width: 100%; } </style><p><strong>wwPDB Validation</strong>&nbsp <span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="right" data-original-title="For each metric, two values are noted, one for the percentile rank of the entry compared to the entire PDB archive and one compared with entries determined with the same experimental method. The blue side of the scale is considered "better" than those on the "worse" red side."> </span><span class="pull-right"><a class="btn btn-default btn-xs" href="/3d-view/4XIW?preset=validationReport"><i class="fa fa-cube">&nbsp</i>3D Report</a>&nbsp<a class="btn btn-default btn-xs" target="_blank" rel="noopener" href="//files.rcsb.org/pub/pdb/validation_reports/xi/4xiw/4xiw_full_validation.pdf">Full Report</a></span></p><div class="validation-slider"><a target="_blank" rel="noopener" href="//files.rcsb.org/pub/pdb/validation_reports/xi/4xiw/4xiw_full_validation.pdf"><img src="//files.rcsb.org/pub/pdb/validation_reports/xi/4xiw/4xiw_multipercentile_validation.png" width="500"></a></div><script src="/js/raphael.min.js"></script><style>div#ligand-validation-container-1, div#ligand-validation-container-2 { border: 1px solid #ddd; } div#ligand-validation-container-2 { width: 500px; } svg { vertical-align: top; } /* see https://stackoverflow.com/questions/22337292/spurious-margin-on-svg-element */ .ligand-validation span.glyphicon { font-size: 14px; } </style><br><p class="ligand-validation"><strong>Ligand Structure Quality Assessment</strong>&nbsp<span class="glyphicon glyphicon-info-sign" data-toggle="tooltip" data-placement="left" data-original-title="Click on a bar to see detailed information about the ligand structure goodness of fit to experimental data for each ligand of interest in 4XIW"></span></p><div id="ligand-validation-container-1"></div><script>var LigandValidation = { draw: function(n) { var p = Raphael('ligand-validation-container-' + n) , data = [{"id":"AZM","fit":0.7816}] , entryId = '4XIW' , tooltips = [] , w = 600 // container w, h , h = 80 , gw = 400 // gradient bar w, h, x, y , gh = 16 , gx = (w - gw) / 2 , gy = (h - gh) / 2 - 8 , lbw = 8 // ligand bar w, h, y , lbh = 28 , lby = (h - lbh) / 2 - 8 , tw = 200 // tooltip w, h, y , th = 75 , ty = (h - th) / 2 , gradient = { fill: '0-#f00-#f9f0f9:50-#00f', 'stroke-width': 0 } // horizontal gradient , ligandRect = { fill: '#337ab7', 'stroke-width': 0, cursor: 'pointer' } // instance bar , tooltipPathAttr = { fill: '#fff', stroke: '#333', 'stroke-width': 1 } , fontsize = (n === 1) ? 18 : 16 , font = { 'font-size': fontsize, fill: '#333' } , caption = 'Ligand structure goodness of fit to experimental data' , tooltipMsg = 'Click on this vertical\nbar to view details' , sp = ' ' p.setViewBox(0, 0, w, h, true) p.setSize('100%', '100%') // horizontal gradient p.rect(gx, gy, gw, gh).attr(gradient) // labels p.text(gx - 40, gy + 8, 'Worse 0').attr(font) p.text(gx + gw + 35, gy + 8, '1 Better').attr(font) // caption p.text(w / 2, 65, caption).attr(font) for (let i = 0; i < data.length; i++) { var id = data[i].id , fit = data[i].fit , x = gx + fit * gw // ligand bar var el = p.rect(x - 4, lby, lbw, lbh).attr(ligandRect).hover( function() { tooltips[i].show() }, function() { tooltips[i].hide() }) el.node.onclick = function(e) { window.location.href = '/ligand-validation/' + entryId + '/' + data[i].id } /* tooltip path - see https://dmitrybaranovskiy.github.io/raphael/reference.html#Paper.path M moveto (x y)+ Z closepath (none) L lineto (x y)+ e.g. var c = paper.path("M10 10L90 90"); */ var path = '' if (fit >= 0.5) { var tx = x - tw - 16 // draw tooltip to the left of the ligand bar path += 'M' + tx + sp + ty path += 'L' + (tx + tw) + sp + ty // right arrow path += 'L' + (tx + tw) + sp + (ty + 22) path += 'L' + (tx + tw + 6) + sp + Math.round(ty + th / 2 - 8) path += 'L' + (tx + tw) + sp + (ty + th - 38) path += 'L' + (tx + tw) + sp + (ty + th) path += 'L' + tx + sp + (ty + th) path += 'Z' } else { var tx = x + 16 // draw tooltip to the right of the ligand bar path += 'M' + tx + sp + ty path += 'L' + (tx + tw) + sp + ty path += 'L' + (tx + tw) + sp + (ty + th) path += 'L' + tx + sp + (ty + th) // left arrow path += 'L' + tx + sp + (ty + th - 38) path += 'L' + (tx - 8) + sp + Math.round(ty + th / 2 - 8) path += 'L' + tx + sp + (ty + 22) path += 'Z' } var tooltipPath = p.path(path).attr(tooltipPathAttr).translate(0.5, 0.5) // see https://stackoverflow.com/questions/8036519/line-width-in-raphaeljs/8058324 var tooltipText = p.text(tx + tw / 2, ty + th / 2 + 2, 'Best fitted ' + id + '\n' + tooltipMsg).attr(font) tooltips[i] = p.set([ tooltipPath, tooltipText ]) tooltips[i].hide() } for (var i = 0; i < tooltips.length; i++) tooltips[i].toFront() // send tooltips to front } } LigandValidation.draw(1)</script></div></div><br><div class="row"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12" id="currentVersionSection"><div class="well well-sm well-nomar">This is version 1.3 of the entry. See complete&nbsp<a href="/versions/4XIW">history</a>.&nbsp</div><br></div></div><br><div class="row"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"><div class="panel panel-default" id="literaturepanel"><div class="panel-heading"><div class="panel-title">Literature<div class="btn-group pull-right"><button class="btn btn-default btn-xs hidden-print dropdown-toggle" type="button" data-toggle="dropdown" aria-expanded="false">Download Primary Citation&nbsp<span class="caret"></span></button><ul class="dropdown-menu DropdownChangeGallery" role="menu"><li><a href="javascript:document.getElementsByTagName('body')[0].appendChild(document.createElement('script')).setAttribute('src','https://www.mendeley.com/minified/bookmarklet.js');"><img src="//cdn.rcsb.org/rcsb-pdb/explorer/SSPv2/images/MendeleyIcon.png" width="16">&nbspDownload Mendeley</a></li></ul></div></div></div><div class="panel-body"><div id="primarycitation"><h4>Crystal Structure and Functional Characterization of Photosystem II-Associated Carbonic Anhydrase CAH3 in Chlamydomonas reinhardtii.</h4><a class="querySearchLink" href="/search?q=citation.rcsb_authors:Benlloch, R." onClick="sendGtag("literature_section", "ssp_search_link", "pubAuthor")">Benlloch, R.</a>,&nbsp<a class="querySearchLink" href="/search?q=citation.rcsb_authors:Shevela, D." onClick="sendGtag("literature_section", "ssp_search_link", "pubAuthor")">Shevela, D.</a>,&nbsp<a class="querySearchLink" href="/search?q=citation.rcsb_authors:Hainzl, T." onClick="sendGtag("literature_section", "ssp_search_link", "pubAuthor")">Hainzl, T.</a>,&nbsp<a class="querySearchLink" href="/search?q=citation.rcsb_authors:Grundstrom, C." onClick="sendGtag("literature_section", "ssp_search_link", "pubAuthor")">Grundstrom, C.</a>,&nbsp<a class="querySearchLink" href="/search?q=citation.rcsb_authors:Shutova, T." onClick="sendGtag("literature_section", "ssp_search_link", "pubAuthor")">Shutova, T.</a>,&nbsp<a class="querySearchLink" href="/search?q=citation.rcsb_authors:Messinger, J." onClick="sendGtag("literature_section", "ssp_search_link", "pubAuthor")">Messinger, J.</a>,&nbsp<a class="querySearchLink" href="/search?q=citation.rcsb_authors:Samuelsson, G." onClick="sendGtag("literature_section", "ssp_search_link", "pubAuthor")">Samuelsson, G.</a>,&nbsp<a class="querySearchLink" href="/search?q=citation.rcsb_authors:Sauer-Eriksson, A.E." onClick="sendGtag("literature_section", "ssp_search_link", "pubAuthor")">Sauer-Eriksson, A.E.</a><br><p>(2015) Plant Physiol&nbsp<strong>167</strong>: 950-962</p><ul class="list-unstyled"><li id="pubmedLinks"><strong>PubMed</strong>:&nbsp<a class="querySearchLink" href="/search?q=rcsb_pubmed_container_identifiers.pubmed_id:25617045" onClick="sendGtag("literature_section", "ssp_search_link", "pubmedId")">25617045</a>&nbsp<span class="label label-external hidden-print"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=25617045" target="_blank" rel="noopener">Search on PubMed</a></span><span class="label label-external hidden-print" style="margin-left: 5px"><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348767" target="_blank" rel="noopener">Search on PubMed Central</a></span></li><li id="pubmedDOI"><strong>DOI:&nbsp</strong><a href="https://doi.org/10.1104/pp.114.253591" target="_blank" rel="noopener">https://doi.org/10.1104/pp.114.253591</a></li><li id="citationPrimaryRelatedStructures" style="word-wrap:break-word;">Primary Citation of Related Structures: &nbsp<br><a href="/structure/4XIW">4XIW</a>, <a href="/structure/4XIX">4XIX</a></li><br><li id="pubmedAbstractText"><strong>PubMed Abstract:&nbsp</strong><br><div class="abstract" id="abstract"><p>In oxygenic photosynthesis, light energy is stored in the form of chemical energy by converting CO2 and water into carbohydrates. The light-driven oxidation of water that provides the electrons and protons for the subsequent CO2 fixation takes place in photosystem II (PSII). Recent studies show that in higher plants, HCO3 (-) increases PSII activity by acting as a mobile acceptor of the protons produced by PSII. In the green alga Chlamydomonas reinhardtii, a luminal carbonic anhydrase, CrCAH3, was suggested to improve proton removal from PSII, possibly by rapid reformation of HCO3 (-) from CO2. In this study, we investigated the interplay between PSII and CrCAH3 by membrane inlet mass spectrometry and x-ray crystallography. Membrane inlet mass spectrometry measurements showed that CrCAH3 was most active at the slightly acidic pH values prevalent in the thylakoid lumen under illumination. Two crystal structures of CrCAH3 in complex with either acetazolamide or phosphate ions were determined at 2.6- and 2.7-Å resolution, respectively. CrCAH3 is a dimer at pH 4.1 that is stabilized by swapping of the N-terminal arms, a feature not previously observed in α-type carbonic anhydrases. The structure contains a disulfide bond, and redox titration of CrCAH3 function with dithiothreitol suggested a possible redox regulation of the enzyme. The stimulating effect of CrCAH3 and CO2/HCO3 (-) on PSII activity was demonstrated by comparing the flash-induced oxygen evolution pattern of wild-type and CrCAH3-less PSII preparations. We showed that CrCAH3 has unique structural features that allow this enzyme to maximize PSII activity at low pH and CO2 concentration.</p></div><button class="btn btn-default btn-xs" onclick="toggleAbstract()" id="toggleBtn" style="margin-top: 3px"><span class="glyphicon glyphicon-plus-sign"></span>&nbspView More</button></li><hr><strong>Organizational Affiliation</strong>:&nbsp<p>Department of Forest Genetics and Plant Physiology (R.B) and Department of Plant Physiology (T.S., G.S.), Umeå Plant Science Centre, and Department of Chemistry, Chemistry Biology Centre (D.S., T.H., C.G., J.M., A.E.S.-E.), Umeå University, SE-90187 Umea, Sweden.</p></ul></div></div></div></div></div></div><div class="col-md-4 col-sm-12 col-xs-12"><script>// Used for Transmembrane Image Carousel var structureFirstLigand = "AZM"; var finalImageCount = 4; var isNMR = false; var modelCount = 1 var assemblies = ["1","2","3","4"]</script><div class="panel panel-default" id="galleryimagepanel"><div class="panel-body" id="structureimagesection"><div class="carousel slide" id="carousel-structuregallery" data-ride="carousel" data-interval="false"><div class="carousel-inner" role="listbox"><div class="item imageCarouselItem" id="Carousel-BiologicalUnit0"><div class="carousel-header">Asymmetric Unit</div><div class="clearfix"></div><img class="img-responsive center-block mainImage" src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" style="image-rendering: -webkit-optimize-contrast;"><a class="btn btn-default btn-xs btn-enlargeImage" type="button" data-toggle="lightbox" data-gallery="multiimages0" href="#" data-title=""><span class="glyphicon glyphicon-resize-full" aria-hidden="true"></span></a><div class="galleryNewImages" id="AssemblyNewImage0"></div><div class="clearfix"></div><div class="carousel-footer"><p><assemblyid class="fa fa-cube">&nbsp</assemblyid><strong>Explore in 3D</strong>:&nbsp<a href="/3d-view/4XIW/0">Structure</a> | <a href="/3d-sequence/4XIW?assemblyId=0">Sequence Annotations</a> | <span class="propernoun"><a href="/3d-view/4XIW?preset=electronDensityMaps">Electron Density</a></span> | <span class="propernoun"><a href="/3d-view/4XIW?preset=validationReport">Validation Report</a></span> | <span class="propernoun"><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=AA">Ligand Interaction</a> (AZM)</span></p></div></div><div class="item imageCarouselItem" id="Carousel-BiologicalUnit1"><div class="carousel-header">Biological Assembly 1 &nbsp<a class="hidden-xs hidden-sm hidden-md icon-link" href="/docs/general-help/computed-structure-models-and-rcsborg#models-and-assembly"><span class="glyphicon glyphicon-question-sign" aria-hidden="true"></span></a></div><div class="clearfix"></div><img class="img-responsive center-block mainImage" src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" style="image-rendering: -webkit-optimize-contrast;"><a class="btn btn-default btn-xs btn-enlargeImage" type="button" data-toggle="lightbox" data-gallery="multiimages1" href="#" data-title=""><span class="glyphicon glyphicon-resize-full" aria-hidden="true"></span></a><div class="galleryNewImages" id="AssemblyNewImage1"></div><div class="clearfix"></div><div class="carousel-footer"><p><assemblyid class="fa fa-cube">&nbsp</assemblyid><strong>Explore in 3D</strong>:&nbsp<a href="/3d-view/4XIW/1">Structure</a> | <a href="/3d-sequence/4XIW?assemblyId=1">Sequence Annotations</a> | <span class="propernoun"><a href="/3d-view/4XIW?preset=electronDensityMaps">Electron Density</a></span> | <span class="propernoun"><a href="/3d-view/4XIW?preset=validationReport">Validation Report</a></span> | <span class="propernoun"><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=AA">Ligand Interaction</a> (AZM)</span></p><hr><strong>Global Symmetry</strong>: Cyclic - C2 <span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Point group symmetry for the biological assembly. Chains are considered equivalent when their sequence identities are above 95%."></span> (<a href="/3d-view/4XIW/1?preset=symmetry&symindex=0">Explore in 3D</a>)<br><strong>Global Stoichiometry</strong>: Homo 2-mer - <span style="word-wrap:break-word;">A2 </span><span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Chains with length below 5 residues or relatively short with respect to other chains are excluded from the stoichiometry and symmetry calculation."></span><div class="hidden-print" id="symmetryPart"></div><div class="hidden-print hide" id="symmetryFull"><br><button class="btn btn-default btn-xs hidden-print" id="full_symmetry_hide"><span class="glyphicon glyphicon-minus-sign"></span> Less</button></div><hr><a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22structure%22%2C%22parameters%22%3A%7B%22value%22%3A%7B%22entry_id%22%3A%224XIW%22%2C%22assembly_id%22%3A%221%22%7D%7D%7D&return_type=assembly" onClick="sendGtag("imageGallery_section", "ssp_search_link", "findSimilarAssemblies")">Find Similar Assemblies</a><hr><p>Biological assembly 1 assigned by authors and generated by PISA (software)</p></div></div><div class="item imageCarouselItem" id="Carousel-BiologicalUnit2"><div class="carousel-header">Biological Assembly 2 &nbsp<a class="hidden-xs hidden-sm hidden-md icon-link" href="/docs/general-help/computed-structure-models-and-rcsborg#models-and-assembly"><span class="glyphicon glyphicon-question-sign" aria-hidden="true"></span></a></div><div class="clearfix"></div><img class="img-responsive center-block mainImage" src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" style="image-rendering: -webkit-optimize-contrast;"><a class="btn btn-default btn-xs btn-enlargeImage" type="button" data-toggle="lightbox" data-gallery="multiimages2" href="#" data-title=""><span class="glyphicon glyphicon-resize-full" aria-hidden="true"></span></a><div class="galleryNewImages" id="AssemblyNewImage2"></div><div class="clearfix"></div><div class="carousel-footer"><p><assemblyid class="fa fa-cube">&nbsp</assemblyid><strong>Explore in 3D</strong>:&nbsp<a href="/3d-view/4XIW/2">Structure</a> | <a href="/3d-sequence/4XIW?assemblyId=2">Sequence Annotations</a> | <span class="propernoun"><a href="/3d-view/4XIW?preset=electronDensityMaps">Electron Density</a></span> | <span class="propernoun"><a href="/3d-view/4XIW?preset=validationReport">Validation Report</a></span> | <span class="propernoun"><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=AA">Ligand Interaction</a> (AZM)</span></p><hr><strong>Global Symmetry</strong>: Cyclic - C2 <span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Point group symmetry for the biological assembly. Chains are considered equivalent when their sequence identities are above 95%."></span> (<a href="/3d-view/4XIW/2?preset=symmetry&symindex=0">Explore in 3D</a>)<br><strong>Global Stoichiometry</strong>: Homo 2-mer - <span style="word-wrap:break-word;">A2 </span><span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Chains with length below 5 residues or relatively short with respect to other chains are excluded from the stoichiometry and symmetry calculation."></span><div class="hidden-print" id="symmetryPart"></div><div class="hidden-print hide" id="symmetryFull"><br><button class="btn btn-default btn-xs hidden-print" id="full_symmetry_hide"><span class="glyphicon glyphicon-minus-sign"></span> Less</button></div><hr><a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22structure%22%2C%22parameters%22%3A%7B%22value%22%3A%7B%22entry_id%22%3A%224XIW%22%2C%22assembly_id%22%3A%222%22%7D%7D%7D&return_type=assembly" onClick="sendGtag("imageGallery_section", "ssp_search_link", "findSimilarAssemblies")">Find Similar Assemblies</a><hr><p>Biological assembly 2 assigned by authors and generated by PISA (software)</p></div></div><div class="item imageCarouselItem" id="Carousel-BiologicalUnit3"><div class="carousel-header">Biological Assembly 3 &nbsp<a class="hidden-xs hidden-sm hidden-md icon-link" href="/docs/general-help/computed-structure-models-and-rcsborg#models-and-assembly"><span class="glyphicon glyphicon-question-sign" aria-hidden="true"></span></a></div><div class="clearfix"></div><img class="img-responsive center-block mainImage" src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" style="image-rendering: -webkit-optimize-contrast;"><a class="btn btn-default btn-xs btn-enlargeImage" type="button" data-toggle="lightbox" data-gallery="multiimages3" href="#" data-title=""><span class="glyphicon glyphicon-resize-full" aria-hidden="true"></span></a><div class="galleryNewImages" id="AssemblyNewImage3"></div><div class="clearfix"></div><div class="carousel-footer"><p><assemblyid class="fa fa-cube">&nbsp</assemblyid><strong>Explore in 3D</strong>:&nbsp<a href="/3d-view/4XIW/3">Structure</a> | <a href="/3d-sequence/4XIW?assemblyId=3">Sequence Annotations</a> | <span class="propernoun"><a href="/3d-view/4XIW?preset=electronDensityMaps">Electron Density</a></span> | <span class="propernoun"><a href="/3d-view/4XIW?preset=validationReport">Validation Report</a></span> | <span class="propernoun"><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=AA">Ligand Interaction</a> (AZM)</span></p><hr><strong>Global Symmetry</strong>: Cyclic - C2 <span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Point group symmetry for the biological assembly. Chains are considered equivalent when their sequence identities are above 95%."></span> (<a href="/3d-view/4XIW/3?preset=symmetry&symindex=0">Explore in 3D</a>)<br><strong>Global Stoichiometry</strong>: Homo 2-mer - <span style="word-wrap:break-word;">A2 </span><span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Chains with length below 5 residues or relatively short with respect to other chains are excluded from the stoichiometry and symmetry calculation."></span><div class="hidden-print" id="symmetryPart"></div><div class="hidden-print hide" id="symmetryFull"><br><button class="btn btn-default btn-xs hidden-print" id="full_symmetry_hide"><span class="glyphicon glyphicon-minus-sign"></span> Less</button></div><hr><a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22structure%22%2C%22parameters%22%3A%7B%22value%22%3A%7B%22entry_id%22%3A%224XIW%22%2C%22assembly_id%22%3A%223%22%7D%7D%7D&return_type=assembly" onClick="sendGtag("imageGallery_section", "ssp_search_link", "findSimilarAssemblies")">Find Similar Assemblies</a><hr><p>Biological assembly 3 assigned by authors and generated by PISA (software)</p></div></div><div class="item imageCarouselItem" id="Carousel-BiologicalUnit4"><div class="carousel-header">Biological Assembly 4 &nbsp<a class="hidden-xs hidden-sm hidden-md icon-link" href="/docs/general-help/computed-structure-models-and-rcsborg#models-and-assembly"><span class="glyphicon glyphicon-question-sign" aria-hidden="true"></span></a></div><div class="clearfix"></div><img class="img-responsive center-block mainImage" src="data:image/gif;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" style="image-rendering: -webkit-optimize-contrast;"><a class="btn btn-default btn-xs btn-enlargeImage" type="button" data-toggle="lightbox" data-gallery="multiimages4" href="#" data-title=""><span class="glyphicon glyphicon-resize-full" aria-hidden="true"></span></a><div class="galleryNewImages" id="AssemblyNewImage4"></div><div class="clearfix"></div><div class="carousel-footer"><p><assemblyid class="fa fa-cube">&nbsp</assemblyid><strong>Explore in 3D</strong>:&nbsp<a href="/3d-view/4XIW/4">Structure</a> | <a href="/3d-sequence/4XIW?assemblyId=4">Sequence Annotations</a> | <span class="propernoun"><a href="/3d-view/4XIW?preset=electronDensityMaps">Electron Density</a></span> | <span class="propernoun"><a href="/3d-view/4XIW?preset=validationReport">Validation Report</a></span> | <span class="propernoun"><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=AA">Ligand Interaction</a> (AZM)</span></p><hr><strong>Global Symmetry</strong>: Cyclic - C2 <span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Point group symmetry for the biological assembly. Chains are considered equivalent when their sequence identities are above 95%."></span> (<a href="/3d-view/4XIW/4?preset=symmetry&symindex=0">Explore in 3D</a>)<br><strong>Global Stoichiometry</strong>: Homo 2-mer - <span style="word-wrap:break-word;">A2 </span><span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Chains with length below 5 residues or relatively short with respect to other chains are excluded from the stoichiometry and symmetry calculation."></span><div class="hidden-print" id="symmetryPart"></div><div class="hidden-print hide" id="symmetryFull"><br><button class="btn btn-default btn-xs hidden-print" id="full_symmetry_hide"><span class="glyphicon glyphicon-minus-sign"></span> Less</button></div><hr><a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22structure%22%2C%22parameters%22%3A%7B%22value%22%3A%7B%22entry_id%22%3A%224XIW%22%2C%22assembly_id%22%3A%224%22%7D%7D%7D&return_type=assembly" onClick="sendGtag("imageGallery_section", "ssp_search_link", "findSimilarAssemblies")">Find Similar Assemblies</a><hr><p>Biological assembly 4 assigned by authors and generated by PISA (software)</p></div></div><a class="left carousel-control" href="#carousel-structuregallery" role="button" data-slide="prev"><span class="glyphicon glyphicon-chevron-left" aria-hidden="true"></span><span class="sr-only">Previous</span></a><a class="right carousel-control" href="#carousel-structuregallery" role="button" data-slide="next"><span class="glyphicon glyphicon-chevron-right" aria-hidden="true"></span><span class="sr-only">Next</span></a></div></div></div></div><div class="well well-sm hidden-sm hidden-xs well-nomar" id="macromoleculeContent"><p><strong>Macromolecule Content</strong></p><ul><li id="contentStructureWeight">Total Structure Weight: 213.41 kDa&nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Molecular weight (in kDa) of all non-water atoms in the deposited model, based on the full deposited sample sequence. Hydrogen atoms are included for the charged state in ARG, HIS & LYS residues."></span></li><li id="contentAtomSiteCount">Atom Count: 15,159&nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Number of modeled non-hydrogen atoms in the deposited model."></span></li><li id="contentResidueCount">Modelled Residue Count: 1,903&nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Number of modeled polymer monomers in the deposited model."></span></li><li id="contentResidueCount">Deposited Residue Count: 1,912&nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Number of all (modeled or unmodeled) polymer monomers in the deposited model."></span></li><li id="contentProteinChainCount">Unique protein chains: 1</li></ul></div></div></div><br></div><div class="panel panel-default" id="macromoleculespanel"><div class="panel-heading"><div class="panel-title">Macromolecules</div></div><div class="panel-body"><div class="row"><div class="col-md-12 col-sm-12 col-xs-12"><div id="MacromoleculeTable"><div style="display: flow-root; margin-bottom: 5px;">Find similar proteins by: <div class="btn-group" role="group"><button class="btn-group btn btn-sm btn-default dropdown-toggle" id="dropdownCutOff" type="button" data-toggle="dropdown" aria-expanded="false" role="group" style="color: #337ab7; text-decoration: none;">Sequence <span class="caret"></span></button><ul class="dropdown-menu" role="menu" aria-labelledby="dropdownCutOff"><li><a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22sequence%22%2C%22parameters%22%3A%7B%22target%22%3A%22pdb_protein_sequence%22%2C%22value%22%3A%22MAAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL%22%2C%22identity_cutoff%22%3A1%7D%7D&return_type=polymer_entity" onClick="sendGtag("macromolecule_section", "ssp_search_link", "proteinBySequenceCutoff")">100%</a></li><li><a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22sequence%22%2C%22parameters%22%3A%7B%22target%22%3A%22pdb_protein_sequence%22%2C%22value%22%3A%22MAAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL%22%2C%22identity_cutoff%22%3A0.95%7D%7D&return_type=polymer_entity" onClick="sendGtag("macromolecule_section", "ssp_search_link", "proteinBySequenceCutoff")">95%</a></li><li><a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22sequence%22%2C%22parameters%22%3A%7B%22target%22%3A%22pdb_protein_sequence%22%2C%22value%22%3A%22MAAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL%22%2C%22identity_cutoff%22%3A0.9%7D%7D&return_type=polymer_entity" onClick="sendGtag("macromolecule_section", "ssp_search_link", "proteinBySequenceCutoff")">90%</a></li><li><a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22sequence%22%2C%22parameters%22%3A%7B%22target%22%3A%22pdb_protein_sequence%22%2C%22value%22%3A%22MAAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL%22%2C%22identity_cutoff%22%3A0.8%7D%7D&return_type=polymer_entity" onClick="sendGtag("macromolecule_section", "ssp_search_link", "proteinBySequenceCutoff")">80%</a></li><li><a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22sequence%22%2C%22parameters%22%3A%7B%22target%22%3A%22pdb_protein_sequence%22%2C%22value%22%3A%22MAAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL%22%2C%22identity_cutoff%22%3A0.7%7D%7D&return_type=polymer_entity" onClick="sendGtag("macromolecule_section", "ssp_search_link", "proteinBySequenceCutoff")">70%</a></li><li><a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22sequence%22%2C%22parameters%22%3A%7B%22target%22%3A%22pdb_protein_sequence%22%2C%22value%22%3A%22MAAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL%22%2C%22identity_cutoff%22%3A0.6%7D%7D&return_type=polymer_entity" onClick="sendGtag("macromolecule_section", "ssp_search_link", "proteinBySequenceCutoff")">60%</a></li><li><a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22sequence%22%2C%22parameters%22%3A%7B%22target%22%3A%22pdb_protein_sequence%22%2C%22value%22%3A%22MAAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL%22%2C%22identity_cutoff%22%3A0.5%7D%7D&return_type=polymer_entity" onClick="sendGtag("macromolecule_section", "ssp_search_link", "proteinBySequenceCutoff")">50%</a></li><li><a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22sequence%22%2C%22parameters%22%3A%7B%22target%22%3A%22pdb_protein_sequence%22%2C%22value%22%3A%22MAAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL%22%2C%22identity_cutoff%22%3A0.4%7D%7D&return_type=polymer_entity" onClick="sendGtag("macromolecule_section", "ssp_search_link", "proteinBySequenceCutoff")">40%</a></li><li><a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22sequence%22%2C%22parameters%22%3A%7B%22target%22%3A%22pdb_protein_sequence%22%2C%22value%22%3A%22MAAWNYGEVAGPPTWKGVCATGKRQSPINIPLNTSAPKVDAEMGEFDFAYGSFEKCDVLNTGHGTMQVNFPAGNLAFIGNMELELLQFHFHAPSEHAMDGRRYAMEAHLVHKNKSTGNLAVLGIMLEPGGLIKNPALSTALEVAPEVPLAKKPSPKGINPVMLLPKKSKAGTRPFVHYPGSLTTPPCSEGVDWFVFMQPIKVPDSQILDFMRFVGDNKTYATNTRPLQLLNSRLVEYEL%22%2C%22identity_cutoff%22%3A0.3%7D%7D&return_type=polymer_entity" onClick="sendGtag("macromolecule_section", "ssp_search_link", "proteinBySequenceCutoff")">30%</a></li></ul></div> (by identity cutoff)  |  <a href="/search?query=%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22structure%22%2C%22parameters%22%3A%7B%22value%22%3A%7B%22entry_id%22%3A%224XIW%22%2C%22asym_id%22%3A%22A%22%7D%7D%7D&return_type=polymer_entity" onClick="sendGtag("macromolecule_section", "ssp_search_link", "proteinBy3Dstructure")">3D Structure</a></div><div class="table-responsive"><a class="entity-anchor" name="entity-1"></a><table class="table table-bordered table-condensed tableEntity" id="table_macromolecule-protein-entityId-1"><tbody><tr class="info" style="color: #315880"><th colspan="6" style="padding-bottom: 0px; padding-top: 0px"><h5 style="font-weight: bold; font-size: 15px">Entity ID: 1</h5></th></tr><tr><th class="col-sm-2 col-lg-2 pad-by-five">Molecule</th><th class="col-sm-2 col-lg-2 pad-by-five">Chains <span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="If the two PDB chain IDs (label_asym_id; assigned by the PDB) and auth_asym_id (selected by the author) do not coincide, the chain ID is displayed as “label_asym_id [auth auth_asym_id]”"></span></th><th class="col-sm-2 col-lg-2 pad-by-five">Sequence Length</th><th class="col-sm-2 col-lg-2 pad-by-five">Organism</th><th class="col-sm-2 col-lg-2 pad-by-five">Details</th><th class="col-sm-2 col-lg-2 pad-by-five">Image</th></tr><tr id="macromolecule-entityId-1-rowDescription"><td>Carbonic anhydrase, alpha type</td><td style="width:200px;"><div id="asymPart_1"><div><a href="/sequence/4XIW#A">A</a>, <a href="/sequence/4XIW#B">B</a>, <a href="/sequence/4XIW#C">C</a>, <a href="/sequence/4XIW#D">D</a>, <a href="/sequence/4XIW#E">E</a></div><span class="glyphicon glyphicon-plus-sign" id="full_asym_show_1"></span></div><div class="hide" id="asymFull_1"><div><a href="/sequence/4XIW#A">A</a>, <a href="/sequence/4XIW#B">B</a>, <a href="/sequence/4XIW#C">C</a>, <a href="/sequence/4XIW#D">D</a>, <a href="/sequence/4XIW#E">E</a>, <a href="/sequence/4XIW#F">F</a>, <a href="/sequence/4XIW#G">G</a>, <a href="/sequence/4XIW#H">H</a></div><button class="btn btn-default btn-xs hidden-print" id="full_asym_hide_1"><span class="glyphicon glyphicon-minus-sign"></span> Less</button></div></td><td>239</td><td><a class="querySearchLink" href="/search?q=rcsb_entity_source_organism.taxonomy_lineage.name:Chlamydomonas reinhardtii" onClick="sendGtag("macromolecule_section", "ssp_search_link", "organism")">Chlamydomonas reinhardtii</a></td><td style="word-break: break-all;"><strong>Mutation(s)</strong>: 0&nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="The number of mutations in this polymer sequence that are engineered from the reference sequence."></span><br><strong>Gene Names:&nbsp</strong><a class="querySearchLink" href="/search?q=rcsb_entity_source_organism.rcsb_gene_name.value:CAH3" onClick="sendGtag("macromolecule_section", "ssp_search_link", "geneName")">CAH3</a><br><strong>EC:&nbsp</strong><a class="querySearchLink" href="/search?q=rcsb_polymer_entity.rcsb_ec_lineage.id:4.2.1.1" onClick="sendGtag("macromolecule_section", "ssp_search_link", "ec")">4.2.1.1</a><br></td><td style="text-align: center; vertical-align: middle"><a data-toggle="lightbox" data-title="4XIW_1: Represented by Chain A" href="https://cdn.rcsb.org/images/structures/4xiw_chain-A.jpeg"><img src="https://cdn.rcsb.org/images/structures/4xiw_chain-A.jpeg" style="width:100px;"></a></td></tr><tr><td colspan="6" style="padding-bottom: 0px; padding-top: 0px; background-color: #f5f5f5;"><h5 style="font-weight: bold; font-size: 15px">UniProt</h5></td></tr><tr><td colspan="6"><div class="col-lg-6 col-md-6 text-left" style="padding-left: 0">Find proteins for&nbsp<a class="querySearchLink" href="/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q39588 AND rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt" onClick="sendGtag("macromolecule_section", "ssp_search_link", "uniprotId")">Q39588</a>&nbsp<i>(Chlamydomonas reinhardtii)</i></div><div class="col-lg-3 col-md-3">Explore&nbsp<span class="label label-rcsb"><a href="/groups/sequence/polymer_entity/Q39588">Q39588</a></span>&nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Explore entries with the same UniProt reference sequence."></span></div><div class="col-lg-3 col-md-3 text-right" style="padding-right: 0">Go to UniProtKB: &nbsp<span class="label label-external"><a href="https://www.uniprot.org/uniprot/Q39588" target="_blank" rel="noopener">Q39588</a></span></div></td></tr><tr><td colspan="6" style="padding-bottom: 0px; padding-top: 0px; background-color: #f5f5f5;"><h5 style="font-weight: bold; font-size: 15px">Entity Groups &nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="This entity has been grouped together with similar entities from other structures. Use the links below to navigate to the corresponding group pages and explore the characteristics of similar entities." style="vertical-align: bottom;"></span></h5></td></tr><tr><td class="col-lg-2 col-md-2">Sequence Clusters</td><td class="col-lg-10 col-md-10 group-membership" colspan="5"><span class="label label-rcsb"><a href="/groups/summary/polymer_entity/63_30">30% Identity<span class="fa fa-clone"></span></a></span><span class="label label-rcsb"><a href="/groups/summary/polymer_entity/107681_50">50% Identity<span class="fa fa-clone"></span></a></span><span class="label label-rcsb"><a href="/groups/summary/polymer_entity/114950_70">70% Identity<span class="fa fa-clone"></span></a></span><span class="label label-rcsb"><a href="/groups/summary/polymer_entity/122939_90">90% Identity<span class="fa fa-clone"></span></a></span><span class="label label-rcsb"><a href="/groups/summary/polymer_entity/110782_95">95% Identity<span class="fa fa-clone"></span></a></span><span class="label label-rcsb"><a href="/groups/summary/polymer_entity/87681_100">100% Identity<span class="fa fa-clone"></span></a></span></td></tr><tr><td class="col-lg-2 col-md-2">UniProt Group</td><td class="col-lg-10 col-md-10 group-membership" colspan="5"><span class="label label-rcsb"><a href="/groups/summary/polymer_entity/Q39588">Q39588<span class="fa fa-clone"></span></a></span></td></tr><tr><td colspan="6" style="padding-bottom: 0px; padding-top: 0px; background-color: #f5f5f5;"><h5 style="font-weight: bold; font-size: 15px; display:inline-block;float:left">Sequence Annotations</h5><h5 style="font-weight: bold; font-size: 15px; display:inline-block;float:right;"><a href="/sequence/4XIW#A">Expand</a></h5></td></tr><tr style="border-bottom: 5px solid #ddd" id="RcsbFv"><td class="ProteinFeatureView" colspan="6"><div id="entity" style="margin-top:20px"><div class="col-xs-12 col-sm-12 col-md-4 col-lg-4 form-group" style="margin-bottom: 0; padding-left: 0"><ul class="list-group" style="margin-bottom:0;display:inline-block;width:50%;"><li class="list-group-item" style="border-color:#fff;"><strong>Reference Sequence</strong></li></ul><div id="rcsbWebAppSelect_1" style="display:inline-block;"></div><div class="material-switch pull-right"></div></div></div><div class="clearfix"></div><div id="rcsbWebApp_1" style="margin-bottom: 50px;"></div><script>var headers = { "Rcsb-Analytics-Traffic-Origin": "internal", "Rcsb-Analytics-Traffic-Stage": "saguaro" }; [window.RcsbFvWebApp, window.RcsbChartWebApp, window.RcsbFv3D].forEach(webApp=>{ if (webApp) { webApp.RcsbRequestContextManager.initializeBorregoClient({ api: RC.sequenceCoordinatesUrl + 'graphql', requestConfig: { headers } }); webApp.RcsbRequestContextManager.initializeYosemiteClient({ api: RC.dataUrl + 'graphql', requestConfig: { headers } }); webApp.RcsbRequestContextManager.initializeArchesClient({ uri: RC.searchUrl + 'query', requestConfig: { headers } }); } });</script><script>setTimeout(function(){ RcsbFvWebApp.buildEntitySummaryFv( "rcsbWebApp_1", "rcsbWebAppSelect_1", "4XIW_1" ); },100) </script></td></tr></tbody></table></div></div></div></div></div></div><div class="panel panel-default" id="smallMoleculespanel"><div class="panel-heading"><div class="panel-title">Small Molecules</div></div><div class="panel-body"><div class="row"><div class="col-md-12 col-sm-12 col-xs-12"><div class="table-responsive" id="LigandsTable"><table class="table table-bordered table-condensed" id="LigandsMainTable"><tr class="active"><th colspan="6">Ligands&nbsp<span class="badge">3 Unique</span></th></tr><tr><th class="col-sm-2 col-lg-2 pad-by-five">ID</th><th class="col-sm-1 col-lg-1 pad-by-five">Chains <span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="If the two PDB chain IDs (label_asym_id; assigned by the PDB) and auth_asym_id (selected by the author) do not coincide, the chain ID is displayed as “label_asym_id [auth auth_asym_id]”"></span></th><th class="col-sm-3 col-lg-4 pad-by-five">Name / Formula / InChI Key</th><th class="col-sm-3 col-lg-3 pad-by-five">2D Diagram</th><th class="col-sm-2 col-lg-2 pad-by-five">3D Interactions</th></tr><tbody><a name="chem-comp-AZM"></a><tr id="ligand_row_AZM"><td><a href="/ligand/AZM">AZM</a><br><a class="hidden-print querySearchLink" href="/search?q=rcsb_chem_comp_container_identifiers.comp_id:AZM" onClick="sendGtag("smallmoleculeLigand_section", "ssp_search_link", "ligandId")">Query on AZM</a><br><hr><a class="btn btn-default btn-xs hidden-print" href="https://files.rcsb.org/ligands/download/AZM.cif">Download Ideal Coordinates CCD File&nbsp<span class="glyphicon glyphicon-download"></span></a><br><div style="display: list-item; margin-bottom: 5px;"><div class="btn-group" role="group" style="position: absolute"><button class="btn btn-xs btn-default dropdown-toggle" id="dropdownMenuDisplayCordinateFiles" type="button" data-toggle="dropdown" aria-expanded="false" role="group">Download Instance Coordinates <span class="caret"></span></button><ul class="dropdown-menu" role="menu" aria-labelledby="dropdownMenuDisplayCordinateFiles"><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=J&encoding=sdf&filename=4xiw_J_AZM.sdf">SDF format, chain J [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=O&encoding=sdf&filename=4xiw_O_AZM.sdf">SDF format, chain O [auth B]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=S&encoding=sdf&filename=4xiw_S_AZM.sdf">SDF format, chain S [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=X&encoding=sdf&filename=4xiw_X_AZM.sdf">SDF format, chain X [auth D]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=AA&encoding=sdf&filename=4xiw_AA_AZM.sdf">SDF format, chain AA [auth E]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=EA&encoding=sdf&filename=4xiw_EA_AZM.sdf">SDF format, chain EA [auth F]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=HA&encoding=sdf&filename=4xiw_HA_AZM.sdf">SDF format, chain HA [auth G]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=KA&encoding=sdf&filename=4xiw_KA_AZM.sdf">SDF format, chain KA [auth H]</a></li><li class="divider"></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=J&encoding=mol2&filename=4xiw_J_AZM.mol2">MOL2 format, chain J [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=O&encoding=mol2&filename=4xiw_O_AZM.mol2">MOL2 format, chain O [auth B]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=S&encoding=mol2&filename=4xiw_S_AZM.mol2">MOL2 format, chain S [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=X&encoding=mol2&filename=4xiw_X_AZM.mol2">MOL2 format, chain X [auth D]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=AA&encoding=mol2&filename=4xiw_AA_AZM.mol2">MOL2 format, chain AA [auth E]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=EA&encoding=mol2&filename=4xiw_EA_AZM.mol2">MOL2 format, chain EA [auth F]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=HA&encoding=mol2&filename=4xiw_HA_AZM.mol2">MOL2 format, chain HA [auth G]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=KA&encoding=mol2&filename=4xiw_KA_AZM.mol2">MOL2 format, chain KA [auth H]</a></li><li class="divider"><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=J&filename=4xiw_J_AZM.cif">mmCIF format, chain J [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=O&filename=4xiw_O_AZM.cif">mmCIF format, chain O [auth B]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=S&filename=4xiw_S_AZM.cif">mmCIF format, chain S [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=X&filename=4xiw_X_AZM.cif">mmCIF format, chain X [auth D]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=AA&filename=4xiw_AA_AZM.cif">mmCIF format, chain AA [auth E]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=EA&filename=4xiw_EA_AZM.cif">mmCIF format, chain EA [auth F]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=HA&filename=4xiw_HA_AZM.cif">mmCIF format, chain HA [auth G]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=402&label_asym_id=KA&filename=4xiw_KA_AZM.cif">mmCIF format, chain KA [auth H]</a></li></li></ul></div></div></td><td><div class="hidden-print" id="asymPart_3">AA [auth E]<br>EA [auth F]<br>HA [auth G]<br>J [auth A]<br>KA [auth H]<br><span class="glyphicon glyphicon-plus-sign" id="full_asym_show_3"></span></div><div class="hidden-print hide" id="asymFull_3">AA [auth E],<br>EA [auth F],<br>HA [auth G],<br>J [auth A],<br>KA [auth H],<br>O [auth B],<br>S [auth C],<br>X [auth D]<button class="btn btn-default btn-xs hidden-print" id="full_asym_hide_3"><span class="glyphicon glyphicon-minus-sign"></span> Less</button></div></td><td><strong>5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE</strong><br>C<sub>4</sub> H<sub>6</sub> N<sub>4</sub> O<sub>3</sub> S<sub>2</sub><br>BZKPWHYZMXOIDC-UHFFFAOYSA-N</td><td><a data-toggle="lightbox" data-title="4XIW: Ligand AZM" href="https://cdn.rcsb.org/images/ccd/labeled/A/AZM.svg"><img src="https://cdn.rcsb.org/images/ccd/unlabeled/A/AZM.svg" style="width:116px; margin: 0 auto; display: block;"></a></td><td><div class="btn-group view-button-3d" role="group" style="position: absolute;"><a class="btn btn-default btn-xs dropdown-toggle" id="dropdownMenuLigandFocus_AZM" type="button" data-toggle="dropdown" aria-expanded="false" role="group" title="Focus on a ligand and show non-covalent interactions with its surroundings."><i class="fa fa-cube"> </i>Interactions  <span class="caret"></span></a><ul class="dropdown-menu" role="menu" aria-labelledby="dropdownMenuLigandFocus_AZM"><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=AA">Focus chain AA [auth E]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=EA">Focus chain EA [auth F]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=HA">Focus chain HA [auth G]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=J">Focus chain J [auth A]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=KA">Focus chain KA [auth H]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=O">Focus chain O [auth B]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=S">Focus chain S [auth C]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=X">Focus chain X [auth D]</a></li></ul></div><div class="btn-group view-button-3d" role="group" style="position: absolute; margin-top: 1.85em;"><a class="btn btn-default btn-xs dropdown-toggle" id="dropdownMenuLigandFocusDensity_AZM" type="button" data-toggle="dropdown" aria-expanded="false" role="group" title="Focus on a ligand and show non-covalent interactions with its surroundings as well as density data."><i class="fa fa-cube"> </i>Interactions & Density  <span class="caret"></span></a><ul class="dropdown-menu" role="menu" aria-labelledby="dropdownMenuLigandFocusDensity_AZM"><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=AA&density=true">Focus chain AA [auth E]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=EA&density=true">Focus chain EA [auth F]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=HA&density=true">Focus chain HA [auth G]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=J&density=true">Focus chain J [auth A]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=KA&density=true">Focus chain KA [auth H]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=O&density=true">Focus chain O [auth B]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=S&density=true">Focus chain S [auth C]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=X&density=true">Focus chain X [auth D]</a></li></ul></div></td></tr><a name="chem-comp-2HP"></a><tr id="ligand_row_2HP"><td><a href="/ligand/2HP">2HP</a><br><a class="hidden-print querySearchLink" href="/search?q=rcsb_chem_comp_container_identifiers.comp_id:2HP" onClick="sendGtag("smallmoleculeLigand_section", "ssp_search_link", "ligandId")">Query on 2HP</a><br><hr><a class="btn btn-default btn-xs hidden-print" href="https://files.rcsb.org/ligands/download/2HP.cif">Download Ideal Coordinates CCD File&nbsp<span class="glyphicon glyphicon-download"></span></a><br><div style="display: list-item; margin-bottom: 5px;"><div class="btn-group" role="group" style="position: absolute"><button class="btn btn-xs btn-default dropdown-toggle" id="dropdownMenuDisplayCordinateFiles" type="button" data-toggle="dropdown" aria-expanded="false" role="group">Download Instance Coordinates <span class="caret"></span></button><ul class="dropdown-menu" role="menu" aria-labelledby="dropdownMenuDisplayCordinateFiles"><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=CA&encoding=sdf&filename=4xiw_CA_2HP.sdf">SDF format, chain CA [auth E]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=IA&encoding=sdf&filename=4xiw_IA_2HP.sdf">SDF format, chain IA [auth G]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=LA&encoding=sdf&filename=4xiw_LA_2HP.sdf">SDF format, chain LA [auth H]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=405&label_asym_id=M&encoding=sdf&filename=4xiw_M_2HP.sdf">SDF format, chain M [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=405&label_asym_id=NA&encoding=sdf&filename=4xiw_NA_2HP.sdf">SDF format, chain NA [auth H]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=Q&encoding=sdf&filename=4xiw_Q_2HP.sdf">SDF format, chain Q [auth B]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=BA&encoding=sdf&filename=4xiw_BA_2HP.sdf">SDF format, chain BA [auth E]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=FA&encoding=sdf&filename=4xiw_FA_2HP.sdf">SDF format, chain FA [auth F]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=K&encoding=sdf&filename=4xiw_K_2HP.sdf">SDF format, chain K [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=L&encoding=sdf&filename=4xiw_L_2HP.sdf">SDF format, chain L [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=MA&encoding=sdf&filename=4xiw_MA_2HP.sdf">SDF format, chain MA [auth H]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=P&encoding=sdf&filename=4xiw_P_2HP.sdf">SDF format, chain P [auth B]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=T&encoding=sdf&filename=4xiw_T_2HP.sdf">SDF format, chain T [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=U&encoding=sdf&filename=4xiw_U_2HP.sdf">SDF format, chain U [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=405&label_asym_id=V&encoding=sdf&filename=4xiw_V_2HP.sdf">SDF format, chain V [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=Y&encoding=sdf&filename=4xiw_Y_2HP.sdf">SDF format, chain Y [auth D]</a></li><li class="divider"></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=CA&encoding=mol2&filename=4xiw_CA_2HP.mol2">MOL2 format, chain CA [auth E]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=IA&encoding=mol2&filename=4xiw_IA_2HP.mol2">MOL2 format, chain IA [auth G]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=LA&encoding=mol2&filename=4xiw_LA_2HP.mol2">MOL2 format, chain LA [auth H]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=405&label_asym_id=M&encoding=mol2&filename=4xiw_M_2HP.mol2">MOL2 format, chain M [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=405&label_asym_id=NA&encoding=mol2&filename=4xiw_NA_2HP.mol2">MOL2 format, chain NA [auth H]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=Q&encoding=mol2&filename=4xiw_Q_2HP.mol2">MOL2 format, chain Q [auth B]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=BA&encoding=mol2&filename=4xiw_BA_2HP.mol2">MOL2 format, chain BA [auth E]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=FA&encoding=mol2&filename=4xiw_FA_2HP.mol2">MOL2 format, chain FA [auth F]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=K&encoding=mol2&filename=4xiw_K_2HP.mol2">MOL2 format, chain K [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=L&encoding=mol2&filename=4xiw_L_2HP.mol2">MOL2 format, chain L [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=MA&encoding=mol2&filename=4xiw_MA_2HP.mol2">MOL2 format, chain MA [auth H]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=P&encoding=mol2&filename=4xiw_P_2HP.mol2">MOL2 format, chain P [auth B]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=T&encoding=mol2&filename=4xiw_T_2HP.mol2">MOL2 format, chain T [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=U&encoding=mol2&filename=4xiw_U_2HP.mol2">MOL2 format, chain U [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=405&label_asym_id=V&encoding=mol2&filename=4xiw_V_2HP.mol2">MOL2 format, chain V [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=Y&encoding=mol2&filename=4xiw_Y_2HP.mol2">MOL2 format, chain Y [auth D]</a></li><li class="divider"><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=CA&filename=4xiw_CA_2HP.cif">mmCIF format, chain CA [auth E]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=IA&filename=4xiw_IA_2HP.cif">mmCIF format, chain IA [auth G]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=LA&filename=4xiw_LA_2HP.cif">mmCIF format, chain LA [auth H]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=405&label_asym_id=M&filename=4xiw_M_2HP.cif">mmCIF format, chain M [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=405&label_asym_id=NA&filename=4xiw_NA_2HP.cif">mmCIF format, chain NA [auth H]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=Q&filename=4xiw_Q_2HP.cif">mmCIF format, chain Q [auth B]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=BA&filename=4xiw_BA_2HP.cif">mmCIF format, chain BA [auth E]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=FA&filename=4xiw_FA_2HP.cif">mmCIF format, chain FA [auth F]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=K&filename=4xiw_K_2HP.cif">mmCIF format, chain K [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=L&filename=4xiw_L_2HP.cif">mmCIF format, chain L [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=MA&filename=4xiw_MA_2HP.cif">mmCIF format, chain MA [auth H]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=P&filename=4xiw_P_2HP.cif">mmCIF format, chain P [auth B]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=T&filename=4xiw_T_2HP.cif">mmCIF format, chain T [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=404&label_asym_id=U&filename=4xiw_U_2HP.cif">mmCIF format, chain U [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=405&label_asym_id=V&filename=4xiw_V_2HP.cif">mmCIF format, chain V [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=403&label_asym_id=Y&filename=4xiw_Y_2HP.cif">mmCIF format, chain Y [auth D]</a></li></li></ul></div></div></td><td><div class="hidden-print" id="asymPart_4">BA [auth E]<br>CA [auth E]<br>FA [auth F]<br>IA [auth G]<br>K [auth A]<br><span class="glyphicon glyphicon-plus-sign" id="full_asym_show_4"></span></div><div class="hidden-print hide" id="asymFull_4">BA [auth E],<br>CA [auth E],<br>FA [auth F],<br>IA [auth G],<br>K [auth A],<br>L [auth A],<br>LA [auth H],<br>M [auth A],<br>MA [auth H],<br>NA [auth H],<br>P [auth B],<br>Q [auth B],<br>T [auth C],<br>U [auth C],<br>V [auth C],<br>Y [auth D]<button class="btn btn-default btn-xs hidden-print" id="full_asym_hide_4"><span class="glyphicon glyphicon-minus-sign"></span> Less</button></div></td><td><strong>DIHYDROGENPHOSPHATE ION</strong><br>H<sub>2</sub> O<sub>4</sub> P<br>NBIIXXVUZAFLBC-UHFFFAOYSA-M</td><td><a data-toggle="lightbox" data-title="4XIW: Ligand 2HP" href="https://cdn.rcsb.org/images/ccd/labeled/2/2HP.svg"><img src="https://cdn.rcsb.org/images/ccd/unlabeled/2/2HP.svg" style="width:116px; margin: 0 auto; display: block;"></a></td><td><div class="btn-group view-button-3d" role="group" style="position: absolute;"><a class="btn btn-default btn-xs dropdown-toggle" id="dropdownMenuLigandFocus_2HP" type="button" data-toggle="dropdown" aria-expanded="false" role="group" title="Focus on a ligand and show non-covalent interactions with its surroundings."><i class="fa fa-cube"> </i>Interactions  <span class="caret"></span></a><ul class="dropdown-menu" role="menu" aria-labelledby="dropdownMenuLigandFocus_2HP"><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=BA">Focus chain BA [auth E]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=CA">Focus chain CA [auth E]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=FA">Focus chain FA [auth F]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=IA">Focus chain IA [auth G]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=K">Focus chain K [auth A]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=L">Focus chain L [auth A]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=LA">Focus chain LA [auth H]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=M">Focus chain M [auth A]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=MA">Focus chain MA [auth H]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=NA">Focus chain NA [auth H]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=P">Focus chain P [auth B]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=Q">Focus chain Q [auth B]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=T">Focus chain T [auth C]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=U">Focus chain U [auth C]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=V">Focus chain V [auth C]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=Y">Focus chain Y [auth D]</a></li></ul></div><div class="btn-group view-button-3d" role="group" style="position: absolute; margin-top: 1.85em;"><a class="btn btn-default btn-xs dropdown-toggle" id="dropdownMenuLigandFocusDensity_2HP" type="button" data-toggle="dropdown" aria-expanded="false" role="group" title="Focus on a ligand and show non-covalent interactions with its surroundings as well as density data."><i class="fa fa-cube"> </i>Interactions & Density  <span class="caret"></span></a><ul class="dropdown-menu" role="menu" aria-labelledby="dropdownMenuLigandFocusDensity_2HP"><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=BA&density=true">Focus chain BA [auth E]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=CA&density=true">Focus chain CA [auth E]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=FA&density=true">Focus chain FA [auth F]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=IA&density=true">Focus chain IA [auth G]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=K&density=true">Focus chain K [auth A]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=L&density=true">Focus chain L [auth A]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=LA&density=true">Focus chain LA [auth H]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=M&density=true">Focus chain M [auth A]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=MA&density=true">Focus chain MA [auth H]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=NA&density=true">Focus chain NA [auth H]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=P&density=true">Focus chain P [auth B]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=Q&density=true">Focus chain Q [auth B]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=T&density=true">Focus chain T [auth C]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=U&density=true">Focus chain U [auth C]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=V&density=true">Focus chain V [auth C]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=Y&density=true">Focus chain Y [auth D]</a></li></ul></div></td></tr><a name="chem-comp-ZN"></a><tr id="ligand_row_ZN"><td><a href="/ligand/ZN">ZN</a><br><a class="hidden-print querySearchLink" href="/search?q=rcsb_chem_comp_container_identifiers.comp_id:ZN" onClick="sendGtag("smallmoleculeLigand_section", "ssp_search_link", "ligandId")">Query on ZN</a><br><hr><a class="btn btn-default btn-xs hidden-print" href="https://files.rcsb.org/ligands/download/ZN.cif">Download Ideal Coordinates CCD File&nbsp<span class="glyphicon glyphicon-download"></span></a><br><div style="display: list-item; margin-bottom: 5px;"><div class="btn-group" role="group" style="position: absolute"><button class="btn btn-xs btn-default dropdown-toggle" id="dropdownMenuDisplayCordinateFiles" type="button" data-toggle="dropdown" aria-expanded="false" role="group">Download Instance Coordinates <span class="caret"></span></button><ul class="dropdown-menu" role="menu" aria-labelledby="dropdownMenuDisplayCordinateFiles"><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=DA&encoding=sdf&filename=4xiw_DA_ZN.sdf">SDF format, chain DA [auth F]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=GA&encoding=sdf&filename=4xiw_GA_ZN.sdf">SDF format, chain GA [auth G]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=I&encoding=sdf&filename=4xiw_I_ZN.sdf">SDF format, chain I [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=JA&encoding=sdf&filename=4xiw_JA_ZN.sdf">SDF format, chain JA [auth H]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=N&encoding=sdf&filename=4xiw_N_ZN.sdf">SDF format, chain N [auth B]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=R&encoding=sdf&filename=4xiw_R_ZN.sdf">SDF format, chain R [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=W&encoding=sdf&filename=4xiw_W_ZN.sdf">SDF format, chain W [auth D]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=Z&encoding=sdf&filename=4xiw_Z_ZN.sdf">SDF format, chain Z [auth E]</a></li><li class="divider"></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=DA&encoding=mol2&filename=4xiw_DA_ZN.mol2">MOL2 format, chain DA [auth F]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=GA&encoding=mol2&filename=4xiw_GA_ZN.mol2">MOL2 format, chain GA [auth G]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=I&encoding=mol2&filename=4xiw_I_ZN.mol2">MOL2 format, chain I [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=JA&encoding=mol2&filename=4xiw_JA_ZN.mol2">MOL2 format, chain JA [auth H]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=N&encoding=mol2&filename=4xiw_N_ZN.mol2">MOL2 format, chain N [auth B]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=R&encoding=mol2&filename=4xiw_R_ZN.mol2">MOL2 format, chain R [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=W&encoding=mol2&filename=4xiw_W_ZN.mol2">MOL2 format, chain W [auth D]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=Z&encoding=mol2&filename=4xiw_Z_ZN.mol2">MOL2 format, chain Z [auth E]</a></li><li class="divider"><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=DA&filename=4xiw_DA_ZN.cif">mmCIF format, chain DA [auth F]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=GA&filename=4xiw_GA_ZN.cif">mmCIF format, chain GA [auth G]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=I&filename=4xiw_I_ZN.cif">mmCIF format, chain I [auth A]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=JA&filename=4xiw_JA_ZN.cif">mmCIF format, chain JA [auth H]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=N&filename=4xiw_N_ZN.cif">mmCIF format, chain N [auth B]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=R&filename=4xiw_R_ZN.cif">mmCIF format, chain R [auth C]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=W&filename=4xiw_W_ZN.cif">mmCIF format, chain W [auth D]</a></li><li><a href="https://models.rcsb.org/v1/4xiw/ligand?auth_seq_id=401&label_asym_id=Z&filename=4xiw_Z_ZN.cif">mmCIF format, chain Z [auth E]</a></li></li></ul></div></div></td><td><div class="hidden-print" id="asymPart_2">DA [auth F]<br>GA [auth G]<br>I [auth A]<br>JA [auth H]<br>N [auth B]<br><span class="glyphicon glyphicon-plus-sign" id="full_asym_show_2"></span></div><div class="hidden-print hide" id="asymFull_2">DA [auth F],<br>GA [auth G],<br>I [auth A],<br>JA [auth H],<br>N [auth B],<br>R [auth C],<br>W [auth D],<br>Z [auth E]<button class="btn btn-default btn-xs hidden-print" id="full_asym_hide_2"><span class="glyphicon glyphicon-minus-sign"></span> Less</button></div></td><td><strong>ZINC ION</strong><br>Zn<br>PTFCDOFLOPIGGS-UHFFFAOYSA-N</td><td><a data-toggle="lightbox" data-title="4XIW: Ligand ZN" href="https://cdn.rcsb.org/images/ccd/labeled/Z/ZN.svg"><img src="https://cdn.rcsb.org/images/ccd/unlabeled/Z/ZN.svg" style="width:116px; margin: 0 auto; display: block;"></a></td><td><div class="btn-group view-button-3d" role="group" style="position: absolute;"><a class="btn btn-default btn-xs dropdown-toggle" id="dropdownMenuLigandFocus_ZN" type="button" data-toggle="dropdown" aria-expanded="false" role="group" title="Focus on a ligand and show non-covalent interactions with its surroundings."><i class="fa fa-cube"> </i>Interactions  <span class="caret"></span></a><ul class="dropdown-menu" role="menu" aria-labelledby="dropdownMenuLigandFocus_ZN"><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=DA">Focus chain DA [auth F]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=GA">Focus chain GA [auth G]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=I">Focus chain I [auth A]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=JA">Focus chain JA [auth H]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=N">Focus chain N [auth B]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=R">Focus chain R [auth C]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=W">Focus chain W [auth D]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=Z">Focus chain Z [auth E]</a></li></ul></div><div class="btn-group view-button-3d" role="group" style="position: absolute; margin-top: 1.85em;"><a class="btn btn-default btn-xs dropdown-toggle" id="dropdownMenuLigandFocusDensity_ZN" type="button" data-toggle="dropdown" aria-expanded="false" role="group" title="Focus on a ligand and show non-covalent interactions with its surroundings as well as density data."><i class="fa fa-cube"> </i>Interactions & Density  <span class="caret"></span></a><ul class="dropdown-menu" role="menu" aria-labelledby="dropdownMenuLigandFocusDensity_ZN"><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=DA&density=true">Focus chain DA [auth F]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=GA&density=true">Focus chain GA [auth G]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=I&density=true">Focus chain I [auth A]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=JA&density=true">Focus chain JA [auth H]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=N&density=true">Focus chain N [auth B]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=R&density=true">Focus chain R [auth C]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=W&density=true">Focus chain W [auth D]</a></li><li><a href="/3d-view/4XIW?preset=ligandInteraction&label_asym_id=Z&density=true">Focus chain Z [auth E]</a></li></ul></div></td></tr></tbody></table></div></div></div></div></div><div class="panel panel-default" id="experimentaldata-validation"><div class="panel-heading"><div class="panel-title">Experimental Data & Validation</div></div><div class="panel-body"><div class="row"><div class="col-md-6 col-sm-12 col-xs-12"><h4>Experimental Data</h4><div class="row"><ul class="list-unstyled col-sm-12 col-lg-12 col-md-12" id="experimentaldatabottom"><li id="exp_details_0_method"><strong>Method:&nbsp</strong>X-RAY DIFFRACTION</li><li id="exp_details_0_diffraction_resolution"><strong>Resolution:&nbsp</strong>2.60 Å</li><li id="exp_details_0_diffraction_rvalueFree"><strong>R-Value Free:&nbsp </strong>0.226 (Depositor), 0.230 (DCC)&nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Depositor: R factors reported by the deposition authors. DCC: R factors re-calculated by DCC software using depositor data"></span></li><li id="exp_details_0_diffraction_rvalueWork"><strong>R-Value Work:&nbsp </strong>0.161 (Depositor), 0.160 (DCC)&nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="Depositor: R factors reported by the deposition authors. DCC: R factors re-calculated by DCC software using depositor data"></span></li><li id="exp_details_0_diffraction_rvalueObserved"><strong>R-Value Observed:&nbsp</strong>0.164&nbsp(Depositor)&nbsp<span class="glyphicon glyphicon-info-sign hidden-xs hidden-sm hidden-md" aria-hidden="true" data-toggle="tooltip" data-placement="top" data-original-title="The residual factor for reflections that satisfy the resolution limits and the criterion that classifies a reflection as "observed" (typically expressed in terms of a sigma(I) or sigma(F) threshold). Depositor: R factors reported by the deposition authors"></span></li></ul><div class="col-lg-12 col-md-12 col-sm-12"><div style="margin-bottom:10px;"><strong>Space Group:&nbsp<a class="querySearchLink" href="/search?q=symmetry.space_group_name_H_M:P 32 2 1" onClick="sendGtag("experimental_section", "ssp_search_link", "spaceGroup")">P 3<sub>2</sub> 2 1</a></strong></div></div><div class="col-lg-12 col-md-12 col-sm-12"><strong>Unit Cell</strong>:<table class="table table-bordered table-condensed" id="unitCellTable"><thead><tr class="active"><th>Length ( Å )</th><th>Angle ( ˚ )</th></tr></thead><tbody><tr><td>a = 139.356</td><td>α = 90</td></tr><tr><td>b = 139.356</td><td>β = 90</td></tr><tr><td>c = 203.209</td><td>γ = 120</td></tr></tbody></table></div></div><strong>Software Package:</strong><table class="table table-bordered table-condensed" id="xraysoftwarePackages"><thead><tr class="active"><th>Software Name</th><th>Purpose</th></tr></thead><tbody><tr><td>PHENIX</td><td>refinement</td></tr><tr><td>XDS</td><td>data reduction</td></tr><tr><td>SCALA</td><td>data scaling</td></tr><tr><td>PHASER</td><td>phasing</td></tr></tbody></table></div><div class="col-md-6 col-sm-12 col-xs-12"><h4>Structure Validation</h4><p id="validationSection">View&nbsp<a target="_blank" rel="noopener" href="//files.rcsb.org/pub/pdb/validation_reports/xi/4xiw/4xiw_full_validation.pdf">Full Validation Report</a></p><a target="_blank" rel="noopener" href="//files.rcsb.org/pub/pdb/validation_reports/xi/4xiw/4xiw_full_validation.pdf"><img class="img-thumbnail" src="//files.rcsb.org/pub/pdb/validation_reports/xi/4xiw/4xiw_multipercentile_validation.png" width="500"></a><br><br><h4 class="ligand-validation">Ligand Structure Quality Assessment&nbsp<span class="glyphicon glyphicon-info-sign" data-toggle="tooltip" data-placement="left" data-original-title="Click on a bar to see detailed information about the ligand structure goodness of fit to experimental data for each ligand of interest in 4XIW"></span></h4><div id="ligand-validation-container-2"></div><script>LigandValidation.draw(2)</script></div></div><br><div class="row"><div class="col-md-6 col-sm-12 col-xs-12"><a class="btn btn-sm btn-default hidden-print" href="/experimental/4XIW">View more in-depth experimental data</a></div></div></div></div><div class="panel panel-default" id="entry-history"><div class="panel-heading"><div class="panel-title">Entry History&nbsp& Funding Information</div></div><div class="panel-body"><div class="row"><div class="col-md-6 col-sm-6 col-xs-12 col-xs-12"><h4>Deposition Data</h4><ul class="list-unstyled" id="DepositionDataList"><li><strong>Released Date:&nbsp</strong>2015-02-11&nbsp</li><strong>Deposition Author(s):&nbsp</strong><a href="/search?q=audit_author.name:Hainzl, T." onClick="sendGtag("entryHistory_section", "ssp_search_link", "depAuthor")">Hainzl, T.</a>, <a href="/search?q=audit_author.name:Grundstrom, C." onClick="sendGtag("entryHistory_section", "ssp_search_link", "depAuthor")">Grundstrom, C.</a>, <a href="/search?q=audit_author.name:Benlloch, R." onClick="sendGtag("entryHistory_section", "ssp_search_link", "depAuthor")">Benlloch, R.</a>, <a href="/search?q=audit_author.name:Shevela, D." onClick="sendGtag("entryHistory_section", "ssp_search_link", "depAuthor")">Shevela, D.</a>, <a href="/search?q=audit_author.name:Shutova, T." onClick="sendGtag("entryHistory_section", "ssp_search_link", "depAuthor")">Shutova, T.</a>, <a href="/search?q=audit_author.name:Messinger, J." onClick="sendGtag("entryHistory_section", "ssp_search_link", "depAuthor")">Messinger, J.</a>, <a href="/search?q=audit_author.name:Samuelsson, G." onClick="sendGtag("entryHistory_section", "ssp_search_link", "depAuthor")">Samuelsson, G.</a>, <a href="/search?q=audit_author.name:Sauer-Eriksson, A.E." onClick="sendGtag("entryHistory_section", "ssp_search_link", "depAuthor")">Sauer-Eriksson, A.E.</a></ul><hr><div class="table-responsive" id="FundingsTable"><table class="table table-bordered table-condensed"><tr class="active"><th class="col-sm-8 col-lg-8 pad-by-five">Funding Organization</th><th class="col-sm-2 col-lg-2 pad-by-five">Location</th><th class="col-sm-2 col-lg-2 pad-by-five">Grant Number</th></tr><tbody><tr><td>Swedish Research Council</td><td>Sweden</td><td>--</td></tr></tbody></table></div></div><div class="col-md-6 col-sm-6 col-xs-12 col-xs-12"><h4>Revision History  <small><a href="/versions/4XIW">(Full details and data files)</a></small></h4><ul id="revisionHistorySection"><li><strong>Version 1.0: 2015-02-11</strong><br>Type: Initial release<br></li><li><strong>Version 1.1: 2015-03-11</strong><br>Changes: Database references </li><li><strong>Version 1.2: 2024-01-10</strong><br>Changes: Data collection, Database references, Derived calculations, Refinement description </li><li><strong>Version 1.3: 2024-11-13</strong><br>Changes: 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