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.clickable-row { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .clickable-row:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // -- PLA workshop at rudbeck row .workshop-rudbeck-row { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .workshop-rudbeck-row:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- AACR 2024 row .aacr-2024-row { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .aacr-2024-row:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- WEBINAR MARCH 26 row .webinar-march26 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .webinar-march26:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- ITOC-2024 row .itoc-2024 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .itoc-2024:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- EAI-2024 row .eai-2024 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .eai-2024:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- spatial biology east coast 2024 row .sbec-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .sbec-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- festival of genomics row .fgb-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .fgb-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- VIB Spatial Omics row .vib-so-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .vib-so-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- EACR row .eacr-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .eacr-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- milano row .milano-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .milano-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- milner row .milner-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .milner-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- mbc row .mbc-24 { box-shadow: rgba(0, 0, 0, 0) 0 0 0; } .mbc-24:hover { box-shadow: rgba(0, 0, 0, 0.16) 0 1px 5px; cursor: pointer; border-radius: 0px; box-shadow: rgba(0, 0, 0, 0.07) 0px 0px 0px 1px; } // ----- nsh row .nsh-24 { box-shadow: 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vc_row-has-fill"><div class="wpb_column vc_column_container vc_col-sm-1 vc_col-lg-1 vc_col-md-1 vc_col-xs-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-10 vc_col-lg-10 vc_col-xs-12"><div class="vc_column-inner vc_custom_1706696317780"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h1 style="text-align: center; color: #ffffff;">Discover the secret life of proteins with Naveni® TriFlex Technology</h1> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_empty_space" style="height: 20px"><span class="vc_empty_space_inner"></span></div></div></div></div></div><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-10 vc_col-lg-10 vc_col-md-10 vc_col-xs-12"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h2><span style="color: #000000;">Navigating the intricacies of cellular proteins</span></h2> <p><span lang="EN-US" xml:lang="EN-US" data-contrast="none">Ever wish there were a way to take a snapshot of two proteins as they interact or remain unbound? Now, the door is open to study protein interplay and functional states while keeping the structural integrity of cells. Our latest innovation, Naveni</span><span lang="EN-US" xml:lang="EN-US" data-contrast="none">® </span><span lang="EN-US" xml:lang="EN-US" data-contrast="none">TriFlex Technology, uncovers protein complex formation and disassembly in response to different stimuli </span><span lang="EN-US" xml:lang="EN-US" data-contrast="none"><em>in situ</em>. </span>This revolutionary proximity-based technology concurrently visualizes two proteins in a free and complex state, within any cell compartment, and enables you to shed light on the hidden lives of proteins. The technology, which is a development of our <a href="https://navinci.se/technology/">Naveni® <em>in situ</em> proximity ligation technology</a>, is built into the product <a href="https://navinci.se/product/naveni-triflex-cell-mr/">Naveni® TriFlex Cell</a> – a kit with the flexibility to be combined with your own primary antibodies.</p> </div> </div> <div class="vc_empty_space" style="height: 40px"><span class="vc_empty_space_inner"></span></div></div></div></div><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img fetchpriority="high" decoding="async" width="1024" height="1024" src="https://navinci.se/wp-content/uploads/2022/11/Naveni-TriFlex-final-version-svg-07.svg" class="vc_single_image-img attachment-large" alt="" title="Naveni TriFlex-final-version-svg-07" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/naveni-triflex-final-version-svg-07/" /></div> </figure> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p><a href="https://navinci.se/product/navenitriflex-cell-mr/" target="_blank" rel="noopener">Naveni® TriFlex Cell</a> <span lang="EN-US" xml:lang="EN-US" data-contrast="auto">relies on two user-determined primary antibodies against the targets of interest, and on proprietary TriFlex Navenibodies (in orange), which are antibody-based proximity reagents. Only proteins located at <40 nm distance are recorded as interacting. Naveni® TriFlex</span><span lang="EN-US" xml:lang="EN-US" data-contrast="auto"> detects total protein A (i.e., both free and in complex with B, yellow), total protein B (maroon), and the AB interaction (blue). The detected A, B and AB signals are amplified and generate fluorescent readout in three channels corresponding to each protein pool.</span></p> </div> </div> </div></div></div></div><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_empty_space" style="height: 40px"><span class="vc_empty_space_inner"></span></div></div></div></div></div><div data-vc-full-width="true" data-vc-full-width-init="false" class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-7 vc_col-lg-7 vc_col-xs-12"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h2><span style="color: #000000;"><strong>From the cradle to the grave</strong></span></h2> <p><strong>Naveni® TriFlex Cell</strong> was used to simultaneously detect free and interacting Lamin B1 and Histone H3</p> <p><strong>Birth:</strong> In mitotic cells, Lamin B signals (yellow) are diffuse due to nuclear envelope breakdown, whereas Histone H3 (magenta) remains around the metaphase plate. Lamin B/Histone H3 complexes (cyan) have disassembled.</p> <p><strong>Life:</strong> In non-dividing cells, free Lamin B is localized in the nuclear envelope, and multiple Lamin/Histone H3 interactions are observed in the nucleoplasm together with chromatin-bound Histone H3.</p> <p><strong>Death:</strong> During the initial stages of oncosis, the dying cell’s nucleus swells and the nucleoplasm contains less densely packed complexes along with unbound Lamin B and Histone H3.</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-4"><div class="vc_column-inner"><div class="wpb_wrapper"><style type="text/css" data-type="the7_shortcodes-inline-css">.gallery-carousel-shortcode.gallery-carousel-shortcode-id-7aa693a4ea41fefb7a9c01a6d89483c9 .owl-nav a { width: 36px; height: 36px; border-radius: 500px; } .dt-arrow-border-on.gallery-carousel-shortcode.gallery-carousel-shortcode-id-7aa693a4ea41fefb7a9c01a6d89483c9 .owl-nav a:not(:hover):before { border-width: 0px; 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} </style><div class="owl-carousel gallery-carousel-shortcode gallery-shortcode dt-gallery-container dt-owl-carousel-call gallery-carousel-shortcode-id-7aa693a4ea41fefb7a9c01a6d89483c9 quick-scale-img enable-bg-rollover meta-info-off dt-arrow-hover-border-on bullets-small-dot-stroke reposition-arrows dt-icon-bg-off arrows-bg-off disable-arrows-hover-bg arrows-hover-bg-on hover-fade " data-scroll-mode="1" data-col-num="61" data-wide-col-num="1" data-laptop-col="1" data-h-tablet-columns-num="1" data-v-tablet-columns-num="1" data-phone-columns-num="1" data-col-gap="10" data-stage-padding="0" data-speed="600" data-autoplay="true" data-autoplay_speed="2000" data-arrows="true" data-bullet="false" data-next-icon="icon-ar-023-r" data-prev-icon="icon-ar-023-l" data-img-shadow-size="12px" data-img-shadow-spread="3px"><div data-post-id="6016" data-date="2022-11-28T15:16:11+01:00" data-name="In mitotic cells, Lamin B signals (yellow) are diffuse due to nuclear envelope breakdown, whereas Histone H3 (magenta) remains around the metaphase plate. Lamin B/Histone H3 complexes (cyan) have been disassembled."><figure class="post"><a href="https://navinci.se/wp-content/uploads/2022/11/Birth.jpg" class="rollover dt-pswp-item" data-large_image_width="1667" data-large_image_height="1342" data-dt-img-description="" title="In mitotic cells, Lamin B signals (yellow) are diffuse due to nuclear envelope breakdown, whereas Histone H3 (magenta) remains around the metaphase plate. Lamin B/Histone H3 complexes (cyan) have been disassembled."><img decoding="async" class="preload-me aspect" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201667%201342'%3E%3C/svg%3E" data-lazy-srcset="https://navinci.se/wp-content/uploads/2022/11/Birth.jpg 1667w" style="--ratio: 1667 / 1342" data-lazy-sizes="(max-width: 1667px) 100vw, 1667px" alt="" width="1667" height="1342" data-lazy-src="https://navinci.se/wp-content/uploads/2022/11/Birth.jpg" /><noscript><img decoding="async" class="preload-me aspect" src="https://navinci.se/wp-content/uploads/2022/11/Birth.jpg" srcset="https://navinci.se/wp-content/uploads/2022/11/Birth.jpg 1667w" style="--ratio: 1667 / 1342" sizes="(max-width: 1667px) 100vw, 1667px" alt="" width="1667" height="1342" /></noscript><span class="gallery-rollover"><span class="gallery-zoom-ico icomoon-the7-font-the7-zoom-01"><span></span></span></span></a></figure></div><div data-post-id="6018" data-date="2022-11-28T15:16:16+01:00" data-name="In non-dividing cells, free Lamin B is localized in the nuclear envelope, and multiple Lamin/Histone H3 interactions are observed in the nucleoplasm together with chromatin-bound Histone H3"><figure class="post"><a href="https://navinci.se/wp-content/uploads/2022/11/Life.jpg" class="rollover dt-pswp-item" data-large_image_width="1667" data-large_image_height="1342" data-dt-img-description="" title="In non-dividing cells, free Lamin B is localized in the nuclear envelope, and multiple Lamin/Histone H3 interactions are observed in the nucleoplasm together with chromatin-bound Histone H3"><img decoding="async" class="preload-me aspect" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201667%201342'%3E%3C/svg%3E" data-lazy-srcset="https://navinci.se/wp-content/uploads/2022/11/Life.jpg 1667w" style="--ratio: 1667 / 1342" data-lazy-sizes="(max-width: 1667px) 100vw, 1667px" alt="" width="1667" height="1342" data-lazy-src="https://navinci.se/wp-content/uploads/2022/11/Life.jpg" /><noscript><img decoding="async" class="preload-me aspect" src="https://navinci.se/wp-content/uploads/2022/11/Life.jpg" srcset="https://navinci.se/wp-content/uploads/2022/11/Life.jpg 1667w" style="--ratio: 1667 / 1342" sizes="(max-width: 1667px) 100vw, 1667px" alt="" width="1667" height="1342" /></noscript><span class="gallery-rollover"><span class="gallery-zoom-ico icomoon-the7-font-the7-zoom-01"><span></span></span></span></a></figure></div><div data-post-id="6017" data-date="2022-11-28T15:16:14+01:00" data-name="During the initial stages of oncosis, the dying cell’s nucleus swells and the nucleoplasm contains less densely packed complexes along with unbound Lamin B and Histone H3."><figure class="post"><a href="https://navinci.se/wp-content/uploads/2022/11/Death.jpg" class="rollover dt-pswp-item" data-large_image_width="1671" data-large_image_height="1342" data-dt-img-description="" title="During the initial stages of oncosis, the dying cell’s nucleus swells and the nucleoplasm contains less densely packed complexes along with unbound Lamin B and Histone H3."><img decoding="async" class="preload-me aspect" src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%201671%201342'%3E%3C/svg%3E" data-lazy-srcset="https://navinci.se/wp-content/uploads/2022/11/Death.jpg 1671w" style="--ratio: 1671 / 1342" data-lazy-sizes="(max-width: 1671px) 100vw, 1671px" alt="" width="1671" height="1342" data-lazy-src="https://navinci.se/wp-content/uploads/2022/11/Death.jpg" /><noscript><img decoding="async" class="preload-me aspect" src="https://navinci.se/wp-content/uploads/2022/11/Death.jpg" srcset="https://navinci.se/wp-content/uploads/2022/11/Death.jpg 1671w" style="--ratio: 1671 / 1342" sizes="(max-width: 1671px) 100vw, 1671px" alt="" width="1671" height="1342" /></noscript><span class="gallery-rollover"><span class="gallery-zoom-ico icomoon-the7-font-the7-zoom-01"><span></span></span></span></a></figure></div></div><div class="vc_empty_space" style="height: 50px"><span class="vc_empty_space_inner"></span></div></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><div data-vc-full-width="true" data-vc-full-width-init="false" class="vc_row wpb_row vc_row-fluid vc_custom_1669640479253 vc_row-has-fill"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_empty_space" style="height: 64px"><span class="vc_empty_space_inner"></span></div></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><div data-vc-full-width="true" data-vc-full-width-init="false" data-vc-stretch-content="true" class="vc_row wpb_row vc_row-fluid vc_custom_1679658213353 vc_row-has-fill"><div class="wpb_column vc_column_container vc_col-sm-2 vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-8"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h2><span style="color: #000000;">Highly abundant proteins visualize cell-cell adhesion</span></h2> <p>Naveni® TriFlex Cell was used to detect the interaction of β-catenin/ E-cadherin, as well as total β-catenin and E-cadherin. Images depict what is seen in each of the three different channels, as well as a merged image. β -catenin and E-cadherin are highly expressed proteins and the interaction between the two proteins is important for cell-cell adhesion.</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-2 vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><div data-vc-full-width="true" data-vc-full-width-init="false" data-vc-stretch-content="true" class="vc_row wpb_row vc_row-fluid vc_custom_1679658190384 vc_row-has-fill vc_column-gap-30 vc_row-o-equal-height vc_row-flex"><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2022/11/BcatEcad_Beta-catenin.png" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20640%20640'%3E%3C/svg%3E" width="640" height="640" alt="Beta-catenin in MCF7 cells" title="Total Beta-catenin" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/bcatecad_beta-catenin/" data-lazy-src="https://navinci.se/wp-content/uploads/2022/11/BcatEcad_Beta-catenin.png" /><noscript><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2022/11/BcatEcad_Beta-catenin.png" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2022/11/BcatEcad_Beta-catenin.png" width="640" height="640" alt="Beta-catenin in MCF7 cells" title="Total Beta-catenin" loading="lazy" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/bcatecad_beta-catenin/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p><strong>Total protein signal of Beta-catenin in MCF7 cells, </strong>signals visualized in FITC filter set (yellow)</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2022/11/BcatEcad_E-cadherin.png" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20640%20640'%3E%3C/svg%3E" width="640" height="640" alt="E-Cadherin in MCF7 cells" title="Total E-Cadherin" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/bcatecad_e-cadherin/" data-lazy-src="https://navinci.se/wp-content/uploads/2022/11/BcatEcad_E-cadherin.png" /><noscript><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2022/11/BcatEcad_E-cadherin.png" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2022/11/BcatEcad_E-cadherin.png" width="640" height="640" alt="E-Cadherin in MCF7 cells" title="Total E-Cadherin" loading="lazy" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/bcatecad_e-cadherin/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr"><strong>Total protein signal of E-Cadherin </strong></span><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr"><strong>in the same MCF7 cells, </strong></span><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr">signals visualized in Cy3 filter set (magenta)</span></p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2022/11/BcatEcad_interaction.png" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20640%20640'%3E%3C/svg%3E" width="640" height="640" alt="Beta-catenin/E-cadherin complex in MCF7 cells" title="Beta-catenin/E-cadherin complex" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/bcatecad_interaction/" data-lazy-src="https://navinci.se/wp-content/uploads/2022/11/BcatEcad_interaction.png" /><noscript><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2022/11/BcatEcad_interaction.png" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2022/11/BcatEcad_interaction.png" width="640" height="640" alt="Beta-catenin/E-cadherin complex in MCF7 cells" title="Beta-catenin/E-cadherin complex" loading="lazy" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/bcatecad_interaction/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr"><strong>Beta-catenin/E-Cadherin interaction </strong></span><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr"><strong>in the same MCF7 cells, </strong></span><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr">signals visualized in Cy5 filter set (cyan)</span></p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20640%20640'%3E%3C/svg%3E" width="640" height="640" alt="B-catening, E-cadherin and their interaction in MCF7 cells" title="B-catening, E-cadherin and their interaction in MCF7 cells" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/b-catening-e-cadherin-and-their-interaction-in-mcf7-cells/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/02/B-catening-E-cadherin-and-their-interaction-in-MCF7-cells.png" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/02/B-catening-E-cadherin-and-their-interaction-in-MCF7-cells.png" width="640" height="640" alt="B-catening, E-cadherin and their interaction in MCF7 cells" title="B-catening, E-cadherin and their interaction in MCF7 cells" loading="lazy" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/b-catening-e-cadherin-and-their-interaction-in-mcf7-cells/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr"><strong>Merge of the three filter sets, </strong></span><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr">Beta-catenin signals in yellow and E-Cadherin signals in magenta. Beta-catenin/E-Cadherin interaction in cyan. Overlapping signal is white.</span></p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><div data-vc-full-width="true" data-vc-full-width-init="false" data-vc-stretch-content="true" class="vc_row wpb_row vc_row-fluid vc_custom_1669641307125 vc_row-has-fill"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_separator wpb_content_element vc_separator_align_center vc_sep_width_90 vc_sep_pos_align_center vc_separator_no_text vc_sep_color_black wpb_content_element wpb_content_element" ><span class="vc_sep_holder vc_sep_holder_l"><span class="vc_sep_line"></span></span><span class="vc_sep_holder vc_sep_holder_r"><span class="vc_sep_line"></span></span> </div></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><div data-vc-full-width="true" data-vc-full-width-init="false" data-vc-stretch-content="true" class="vc_row wpb_row vc_row-fluid vc_custom_1679658213353 vc_row-has-fill"><div class="wpb_column vc_column_container vc_col-sm-2 vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-8"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h2><span style="color: #000000;"><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr">Overlap of fluorescent</span><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr"> s</span><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr">ignals</span><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr"> is not a synonym for protein interaction</span></span></h2> <p><strong>What appears to be an overlap of two fluorescent signals needs to be distinguished from protein-protein interaction. Learn how and why below.</strong></p> <p>Naveni® TriFlex Cell is used to simultaneously detect two target proteins and their interaction. <span class="NormalTextRun SCXW116478109 BCX8" data-ccp-parastyle="Normal (Web)">In the example below, t</span><span class="NormalTextRun SCXW116478109 BCX8" data-ccp-parastyle="Normal (Web)">he protein targets</span> reside in separate cellular compartments and are not expected to interact. In line with this, the mitochondrial protein COX1 (FITC, in yellow) and the Golgi apparatus protein GM130 (Cy3, in magenta) are clearly detected in their respective compartments but no proximity signal is generated (Cy5, in cyan). Notably, the proteins appear to be present in the same physical structure in the cell – there is an overlap of fluorescence when channels are merged. In traditional immunofluorescence, this could falsely be interpreted as co-localization and interacting proteins.</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-2 vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><div data-vc-full-width="true" data-vc-full-width-init="false" data-vc-stretch-content="true" class="vc_row wpb_row vc_row-fluid vc_custom_1679658190384 vc_row-has-fill vc_column-gap-30 vc_row-o-equal-height vc_row-flex"><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2023/02/COX1-in-MCF7-cells-1024x855.png" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20640%20640'%3E%3C/svg%3E" width="640" height="640" alt="COX1 in MCF7 cells" title="COX1 in MCF7 cells" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/cox1-in-mcf7-cells/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/02/COX1-in-MCF7-cells-640x640.png" /><noscript><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2023/02/COX1-in-MCF7-cells-1024x855.png" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/02/COX1-in-MCF7-cells-640x640.png" width="640" height="640" alt="COX1 in MCF7 cells" title="COX1 in MCF7 cells" loading="lazy" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/cox1-in-mcf7-cells/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr"><strong>Total protein signal of COX1 in MCF7 cells</strong>, </span><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr">signals visualized in FITC filter set (yellow), nuclei shown in blue.</span></p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2023/02/GM130-in-MCF7-cells-1024x855.png" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20640%20640'%3E%3C/svg%3E" width="640" height="640" alt="GM130 in MCF7 cells" title="GM130 in MCF7 cells" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/gm130-in-mcf7-cells/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/02/GM130-in-MCF7-cells-640x640.png" /><noscript><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2023/02/GM130-in-MCF7-cells-1024x855.png" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/02/GM130-in-MCF7-cells-640x640.png" width="640" height="640" alt="GM130 in MCF7 cells" title="GM130 in MCF7 cells" loading="lazy" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/gm130-in-mcf7-cells/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr"><strong>Total protein signal of GM130 in the same MCF7 cells, </strong></span><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr">signals visualized in Cy3 filter set (magenta), nuclei shown in blue.</span></p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2023/02/COX1-and-GM130-interaction-in-MCF7-cells-1024x855.png" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20640%20640'%3E%3C/svg%3E" width="640" height="640" alt="COX1 and GM130 interaction in MCF7 cells" title="COX1 and GM130 interaction in MCF7 cells" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/cox1-and-gm130-interaction-in-mcf7-cells/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/02/COX1-and-GM130-interaction-in-MCF7-cells-640x640.png" /><noscript><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2023/02/COX1-and-GM130-interaction-in-MCF7-cells-1024x855.png" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/02/COX1-and-GM130-interaction-in-MCF7-cells-640x640.png" width="640" height="640" alt="COX1 and GM130 interaction in MCF7 cells" title="COX1 and GM130 interaction in MCF7 cells" loading="lazy" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/cox1-and-gm130-interaction-in-mcf7-cells/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr"><strong>Undetectable signals for COX1/GM130 interaction in the same MCF7 cells</strong>, </span><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr">signals visualized in Cy5 filter set (cyan), nuclei shown in blue. </span></p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2023/02/COX1-GM130-and-their-interaction-in-MCF7-cells-1024x855.png" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20640%20640'%3E%3C/svg%3E" width="640" height="640" alt="COX1, GM130 and their interaction in MCF7 cells" title="COX1, GM130 and their interaction in MCF7 cells" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/cox1-gm130-and-their-interaction-in-mcf7-cells/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/02/COX1-GM130-and-their-interaction-in-MCF7-cells-640x640.png" /><noscript><img decoding="async" data-vc-zoom="https://navinci.se/wp-content/uploads/2023/02/COX1-GM130-and-their-interaction-in-MCF7-cells-1024x855.png" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/02/COX1-GM130-and-their-interaction-in-MCF7-cells-640x640.png" width="640" height="640" alt="COX1, GM130 and their interaction in MCF7 cells" title="COX1, GM130 and their interaction in MCF7 cells" loading="lazy" data-dt-location="https://navinci.se/technology/naveni-triflex-technology/cox1-gm130-and-their-interaction-in-mcf7-cells/" /></noscript></div> </figure> </div> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr"><strong>Merge of the three filter sets, </strong></span><span class="ui-provider vw b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr">COX1 signals in yellow and GM130 signals in magenta. Where COX1 and GM130 signals overlap, the signal is white and could falsely be interpreted as interaction.</span></p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><section class="vc_section vc_custom_1706701370761"><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 vc_hidden-md vc_hidden-sm vc_col-xs-12"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h2 style="color: #000000; font-size: 24px; line-height: 28px;">How to detect free and interacting proteins</h2> <p style="font-size: 16px; line-height: 28px;">Use or flexible product Naveni®TriFlex Cell. If you are only interested in one protein-protein interaction, we recommend NaveniFlex Cell.</p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-5"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-10 vc_hidden-lg vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <h2 style="color: #000000; font-size: 24px; line-height: 28px;">How to detect free and interacting proteins</h2> <p style="font-size: 16px; line-height: 28px;">Use or flexible product Naveni®TriFlex Cell. If you are only interested in one protein-protein interaction, we recommend NaveniFlex Cell.</p> </div> </div> </div></div></div></div><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-1"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-4 vc_col-lg-4 vc_hidden-md vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_row wpb_row vc_inner vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-5"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_center"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20200%20300'%3E%3C/svg%3E" width="200" height="300" alt="Naveni TriFlex Histone H3 Lamin B protein detection and interaction" title="Naveni TriFlex Histone H3 Lamin B protein detection and interaction" data-dt-location="https://navinci.se/?attachment_id=6063" data-lazy-src="https://navinci.se/wp-content/uploads/2022/11/Header-Image-Histone-H3-Lamin-B-200x300.jpg" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2022/11/Header-Image-Histone-H3-Lamin-B-200x300.jpg" width="200" height="300" alt="Naveni TriFlex Histone H3 Lamin B protein detection and interaction" title="Naveni TriFlex Histone H3 Lamin B protein detection and interaction" loading="lazy" data-dt-location="https://navinci.se/?attachment_id=6063" /></noscript></div> </figure> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p style="font-size: 16px; line-height: 28px;"><strong>Naveni TriFlex Cell</strong></p> <p style="font-size: 14px; line-height: 25px;">The kit enables fluorescent staining of protein-protein interactions, concurrently visualizing the two proteins in their free state.</p> </div> </div> <div class="vc_btn3-container vc_btn3-inline" ><a class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-square vc_btn3-style-flat vc_btn3-color-warning" href="https://navinci.se/product/naveni-triflex-cell-mr/" title="Naveni TriFlex Cell MR">View product</a></div></div></div></div></div></div></div></div><div class="wpb_column vc_column_container vc_col-sm-4 vc_hidden-md vc_hidden-sm vc_hidden-xs"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_row wpb_row vc_inner vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-5"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20200%20300'%3E%3C/svg%3E" width="200" height="300" alt="Histone H3 Lamin B1 interaction in MCF7 cells 2" title="Histone H3 Lamin B1 interaction in MCF7 cells 2" data-dt-location="https://navinci.se/applications/assay-database/histone-h3-and-lamin-b1/histon-h3-lamin-b1-interaction-in-mcf7-cells-2/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/12/Histon-H3-Lamin-B1-interaction-in-MCF7-cells-2-200x300.jpg" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/12/Histon-H3-Lamin-B1-interaction-in-MCF7-cells-2-200x300.jpg" width="200" height="300" alt="Histone H3 Lamin B1 interaction in MCF7 cells 2" title="Histone H3 Lamin B1 interaction in MCF7 cells 2" loading="lazy" data-dt-location="https://navinci.se/applications/assay-database/histone-h3-and-lamin-b1/histon-h3-lamin-b1-interaction-in-mcf7-cells-2/" /></noscript></div> </figure> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p style="font-size: 16px; line-height: 28px;"><strong>NaveniFlex Cell</strong></p> <p style="font-size: 14px; line-height: 25px;">The assay is designed to be used with a mouse and rabbit primary antibody pair. Detection with TEX615 fluorophore is included.</p> </div> </div> <div class="vc_btn3-container vc_btn3-inline" ><a class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-square vc_btn3-style-flat vc_btn3-color-warning" href="https://navinci.se/product/naveniflex-cell-mr-atto647n/" title="NaveniFlex Cell MR Atto647N">View product</a></div></div></div></div></div></div></div></div><div class="wpb_column vc_column_container vc_col-sm-3"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div><div class="vc_row wpb_row vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-6 vc_hidden-lg"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_row wpb_row vc_inner vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20280%20175'%3E%3C/svg%3E" width="280" height="175" alt="Naveni TriFlex Histone H3 Lamin B protein detection and interaction" title="Naveni TriFlex Histone H3 Lamin B protein detection and interaction" data-dt-location="https://navinci.se/?attachment_id=6063" data-lazy-src="https://navinci.se/wp-content/uploads/2022/11/Header-Image-Histone-H3-Lamin-B-280x175.jpg" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2022/11/Header-Image-Histone-H3-Lamin-B-280x175.jpg" width="280" height="175" alt="Naveni TriFlex Histone H3 Lamin B protein detection and interaction" title="Naveni TriFlex Histone H3 Lamin B protein detection and interaction" loading="lazy" data-dt-location="https://navinci.se/?attachment_id=6063" /></noscript></div> </figure> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p style="font-size: 16px; line-height: 28px;"><strong>Naveni TriFlex Cell</strong></p> <p style="font-size: 14px; line-height: 25px;">The kit enables fluorescent staining of protein-protein interactions, concurrently visualizing the two proteins in their free state.</p> </div> </div> <div class="vc_btn3-container vc_btn3-inline" ><a class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-square vc_btn3-style-flat vc_btn3-color-warning" href="https://navinci.se/product/naveni-triflex-cell-mr/" title="Naveni TriFlex Cell MR">View product</a></div></div></div></div></div></div></div></div><div class="wpb_column vc_column_container vc_col-sm-6 vc_col-lg-6 vc_hidden-lg"><div class="vc_column-inner"><div class="wpb_wrapper"><div class="vc_row wpb_row vc_inner vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_single_image wpb_content_element vc_align_left"> <figure class="wpb_wrapper vc_figure"> <div class="vc_single_image-wrapper vc_box_border_grey"><img decoding="async" class="vc_single_image-img " src="data:image/svg+xml,%3Csvg%20xmlns='http://www.w3.org/2000/svg'%20viewBox='0%200%20280%20175'%3E%3C/svg%3E" width="280" height="175" alt="Histone H3 Lamin B1 interaction in MCF7 cells 2" title="Histone H3 Lamin B1 interaction in MCF7 cells 2" data-dt-location="https://navinci.se/applications/assay-database/histone-h3-and-lamin-b1/histon-h3-lamin-b1-interaction-in-mcf7-cells-2/" data-lazy-src="https://navinci.se/wp-content/uploads/2023/12/Histon-H3-Lamin-B1-interaction-in-MCF7-cells-2-280x175.jpg" /><noscript><img decoding="async" class="vc_single_image-img " src="https://navinci.se/wp-content/uploads/2023/12/Histon-H3-Lamin-B1-interaction-in-MCF7-cells-2-280x175.jpg" width="280" height="175" alt="Histone H3 Lamin B1 interaction in MCF7 cells 2" title="Histone H3 Lamin B1 interaction in MCF7 cells 2" loading="lazy" data-dt-location="https://navinci.se/applications/assay-database/histone-h3-and-lamin-b1/histon-h3-lamin-b1-interaction-in-mcf7-cells-2/" /></noscript></div> </figure> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-6"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p style="font-size: 16px; line-height: 28px;"><strong>NaveniFlex Cell</strong></p> <p style="font-size: 14px; line-height: 25px;">The assay is designed to be used with a mouse and rabbit primary antibody pair. Detection with TEX615 fluorophore is included.</p> </div> </div> <div class="vc_btn3-container vc_btn3-inline" ><a class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-square vc_btn3-style-flat vc_btn3-color-warning" href="https://navinci.se/product/naveniflex-cell-mr-atto647n/" title="NaveniFlex Cell MR Atto647N">View product</a></div></div></div></div></div></div></div></div></div></section><section class="vc_section"><div data-vc-full-width="true" data-vc-full-width-init="false" class="vc_row wpb_row vc_row-fluid vc_custom_1669640486983 vc_row-has-fill"><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-8"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element " > <div class="wpb_wrapper"> <p><strong>Expert opinion: </strong></p> <p><em>’The TriFlex product makes it possible to measure protein co-location with high precision, independent of microscope resolution.’ </em></p> <p><span data-contrast="auto">This is what <a href="https://user.it.uu.se/~cli05194/index.html" target="_blank" rel="noopener">imaging expert Carolina Wählby</a>, professor in quantitative microscopy at the Dept. of Information Technology and SciLifeLab, and main contributor to the development of image analysis software CellProfiler, had to say about our newest technology.</span></p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-2"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div></section> </div> </div> </div> </div> </div>  <footer data-wpr-lazyrender="1" id="footer" class="footer solid-bg"> <div class="wf-wrap"> <div class="wf-container-footer"> <div class="wf-container"> <section id="custom_html-2" class="widget_text widget widget_custom_html wf-cell wf-1-2"><div class="widget-title">Contact us</div><div class="textwidget custom-html-widget"><p>Email: <a href="mailto:contact@navinci.se">contact@navinci.se</a></p></div></section><section id="nav_menu-2" class="widget widget_nav_menu wf-cell wf-1-2"><div class="widget-title">Menu</div><div class="menu-footern-container"><ul id="menu-footern" class="menu"><li id="menu-item-9270" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-9270"><a href="https://navinci.se/products/">Products</a></li> <li id="menu-item-9282" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-9282"><a href="https://navinci.se/technology/">Technology</a></li> <li id="menu-item-9283" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-9283"><a href="https://navinci.se/applications/">Applications</a></li> <li id="menu-item-9284" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-9284"><a href="https://navinci.se/support/">Support</a></li> <li id="menu-item-9285" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-9285"><a href="https://navinci.se/about/">About</a></li> </ul></div></section> </div> </div> </div>  <div id="bottom-bar" class="logo-left" role="contentinfo"> <div class="wf-wrap"> <div class="wf-container-bottom"> <div class="wf-float-right"> <div class="bottom-text-block"><p><a class="elementor-icon" href="https://www.linkedin.com/company/navinci-diagnostics/"><i class="fa fa-linkedin-square" aria-hidden="true"></i></a></p> </div> </div> </div> </div> </div> </footer> <a href="#" class="scroll-top"><svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 16 16" style="enable-background:new 0 0 16 16;" xml:space="preserve"> <path d="M11.7,6.3l-3-3C8.5,3.1,8.3,3,8,3c0,0,0,0,0,0C7.7,3,7.5,3.1,7.3,3.3l-3,3c-0.4,0.4-0.4,1,0,1.4c0.4,0.4,1,0.4,1.4,0L7,6.4 V12c0,0.6,0.4,1,1,1s1-0.4,1-1V6.4l1.3,1.3c0.4,0.4,1,0.4,1.4,0C11.9,7.5,12,7.3,12,7S11.9,6.5,11.7,6.3z"/> </svg><span class="screen-reader-text">Go to Top</span></a> </div> <script> window.RS_MODULES = window.RS_MODULES || {}; 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