CINXE.COM

<!DOCTYPE html> <html> <head><link rel="stylesheet" type="text/css" href="/DXR.axd?r=0_2312,1_50,1_53,1_51,0_2317-HCSds&p=3566a23a" /><link rel="stylesheet" type="text/css" href="/DXR.axd?r=0_2214,1_16,0_2219,1_17-HCSds&p=3566a23a" /><meta charset="utf-8" /><meta name="viewport" content="width=device-width, initial-scale=0.3" /><link rel="shortcut icon" href="/favicon.ico" /><title> Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar </title><script src="/bundles/jquery?v=uFgEwkmfdwWoDMz6vEeIoql0PDF7uHxE-GEoIW9UY9M1"></script> <script src="/bundles/json2?v=d1Efh1-9UFdw-Pnj4VVUxViXmZK9H1kqbY_kx2U79DM1"></script> <script src="/bundles/site?v=Uby6LDuaSQ1_He97UGZvnGv_wln5mTgGNE3q1RwRMEQ1"></script> <link href="/Style/css?v=moasmn2BWK6Px64tnr4mMXZfX9KqyGOs6yBj9kZctxQ1" rel="stylesheet"/> <script src="/bundles/search?v=oKWBTbQ1Eyu3c78HTcS6WrXwgMWPpz68IXv5mSC3oqQ1"></script>  <script async src="https://www.googletagmanager.com/gtag/js?id=UA-221132522-1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag() { dataLayer.push(arguments); } gtag('js', new Date()); gtag('config', 'UA-221132522-1'); </script> <script type="text/javascript"> $(function () { InitCategoryIcon(); AddArticleSearchRecord(); }); </script> <meta name="application-name" content="ReferenceCitationAnalysis" /> <meta name="msapplication-TileColor" content="#bd4100" /> <meta name="description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> <meta property="og:site" content="ReferenceCitationAnalysis" /> <meta property="og:site_name" content="ReferenceCitationAnalysis" /> <meta property="og:type" content="website" /> <meta property="og:url" content="https://referencecitationanalysis.com/" /> <meta property="og:title" content="Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar" /> <meta property="og:description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> <meta name="twitter:title" content="Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://referencecitationanalysis.com/" /> <meta name="twitter:description" content="Reference Citation Analysis (RCA) is a unique artificial intelligence system for citation evaluation of biomedical literature. RCA is committed to providing a platform for discovery of high-quality articles, journals, scholars, and academic assistants by biomedical researchers, universities, hospitals, research institutions, funding agencies, librarians, publishers, and journal editors worldwide." /> </head> <body> <form method="post" action="./search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" id="form1"> <div class="aspNetHidden"> <input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="" /> <input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="" /> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" value="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" /> </div> <script type="text/javascript"> //<![CDATA[ var theForm = document.forms['form1']; if (!theForm) { theForm = document.form1; } function __doPostBack(eventTarget, eventArgument) { if (!theForm.onsubmit || (theForm.onsubmit() != false)) { theForm.__EVENTTARGET.value = eventTarget; theForm.__EVENTARGUMENT.value = eventArgument; theForm.submit(); } } //]]> </script> <script src="/WebResource.axd?d=pynGkmcFUV13He1Qd6_TZDkCPVD1CEgIJIwX-djYyD12MdD7MbGguneDtbgL0T4_DTGNirF3uaaW3m5irAIXOA2&t=638628207619783110" type="text/javascript"></script> <script id="dxis_725862373" src="/DXR.axd?r=1_304-HCSds" type="text/javascript"></script><script id="dxis_117419880" src="/DXR.axd?r=1_185-HCSds" type="text/javascript"></script><script id="dxis_2117664241" src="/DXR.axd?r=1_188-HCSds" type="text/javascript"></script> <div class="aspNetHidden"> <input type="hidden" name="__VIEWSTATEGENERATOR" id="__VIEWSTATEGENERATOR" value="54D499A9" /> <input type="hidden" name="__EVENTVALIDATION" id="__EVENTVALIDATION" value="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" /> </div> <input type="hidden"/><script id="dxis_1899801520" src="/DXR.axd?r=1_298,1_211,1_221,1_182,1_277,1_198,1_209,1_217,1_190,1_223,1_208,1_290,1_206,1_288,1_212,1_286,1_296,1_299,1_224,1_201,1_216-HCSds" type="text/javascript"></script><table class="dxlpLoadingPanel_MetropolisBlue dxlpControl_MetropolisBlue" id="ASPxLoadingPanel" style="position:absolute;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="width:0px;vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="ASPxLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="ASPxLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1948350305" type="text/javascript">  </script> <div class="top-part cl"> <div class="top-content" id="top"> <ul class="ul"> <li class="logo fl"> <a href="https://www.wjgnet.com" target="_blank"> <img src="/Contents/Images/Bpg-logo-new.svg" /> </a> </li> <li class="rca-title fl"> <a href="/" class="clearlink"> <img src="../Contents/Images/RCA-Logo.svg" alt="Reference Citation Analysis" /> </a> </li> <li id="PageTopControl_loginContainer" class="logined fr"> <table> <tr> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_Login" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_Login_I" class="dxb-hb" value="Login" type="submit" name="ctl00$PageTopControl$Login" /><span class="dx-vam">Login</span> </div> </div><script id="dxss_309739120" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_AuthorRegist" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_AuthorRegist_I" class="dxb-hb" value="Scholar Register" type="submit" name="ctl00$PageTopControl$AuthorRegist" /><span class="dx-vam">Scholar Register</span> </div> </div><script id="dxss_216236472" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_BusinessRegist" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_BusinessRegist_I" class="dxb-hb" value="Business Register" type="submit" name="ctl00$PageTopControl$BusinessRegist" /><span class="dx-vam">Business Register</span> </div> </div><script id="dxss_1760396766" type="text/javascript">  </script> </td> <td> <div class="dxbButton_MetropolisBlue MenuButton DefaultButton-Shadow dxbButtonSys dxbTSys" id="PageTopControl_Subscribe" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="PageTopControl_Subscribe_I" class="dxb-hb" value="Subscribe" type="submit" name="ctl00$PageTopControl$Subscribe" /><span class="dx-vam">Subscribe</span> </div> </div><script id="dxss_1089838522" type="text/javascript">  </script> </td> </tr> </table> </li> </ul> </div> </div> <div class="main-part cl"> <div class="main-search-container"> <div class="search-form search-centered"> <div class="search-component-container"> <ul class="ul cl"> <li class="fl"> <table id="FieldItems_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="FieldItems_TL">Loading…</span></td> </tr> </table><div id="FieldItems_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue devex-combobox FieldItems" id="FieldItems"> <tr> <td style="display:none;"><input id="FieldItems_VI" name="FieldItems_VI" type="hidden" value="kw" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('FieldItems', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="FieldItems_I" name="ctl00$FieldItems" onfocus="ASPx.EGotFocus('FieldItems')" onblur="ASPx.ELostFocus('FieldItems')" onchange="ASPx.ETextChanged('FieldItems')" value="Keyword" type="text" /></td><td id="FieldItems_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('FieldItems', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="FieldItems_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="FieldItems_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="FieldItems_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="FieldItems_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="FieldItems_DDD_L_VI" type="hidden" name="ctl00$FieldItems$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="FieldItems_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="FieldItems_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="FieldItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Article Title</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Abstract</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Keyword</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Category</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">MESH Heading</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Grant Agency</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">RCAID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">DOI</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PMCID</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Author</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Affiliation</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Email</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Journal Title</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">ISSN</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Publisher</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1279325514" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1280586772" type="text/javascript">  </script><script id="dxss_723598773" type="text/javascript">  </script> </li> <li class="fl"> <table id="OpeartorItems_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="OpeartorItems_TL">Loading…</span></td> </tr> </table><div id="OpeartorItems_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue devex-combobox OpeartorItems" id="OpeartorItems"> <tr> <td style="display:none;"><input id="OpeartorItems_VI" name="OpeartorItems_VI" type="hidden" value="Equals" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('OpeartorItems', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="OpeartorItems_I" name="ctl00$OpeartorItems" onfocus="ASPx.EGotFocus('OpeartorItems')" onblur="ASPx.ELostFocus('OpeartorItems')" onchange="ASPx.ETextChanged('OpeartorItems')" value="Equals" type="text" /></td><td id="OpeartorItems_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('OpeartorItems', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="OpeartorItems_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="OpeartorItems_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="OpeartorItems_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="OpeartorItems_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="OpeartorItems_DDD_L_VI" type="hidden" name="ctl00$OpeartorItems$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="OpeartorItems_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="OpeartorItems_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="OpeartorItems_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Contains</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Equals</td> </tr> </table> </div></td> </tr> </table><script id="dxss_597138281" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_24426426" type="text/javascript">  </script><script id="dxss_1793334323" type="text/javascript">  </script> </li> <li id="TermInputContainer" class="fl TermInputContainer"> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue input-text SearchTermText dxeTextBoxDefaultWidthSys" id="SearchTerm"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="SearchTerm_I" name="ctl00$SearchTerm" onfocus="ASPx.EGotFocus('SearchTerm')" onblur="ASPx.ELostFocus('SearchTerm')" onchange="ASPx.EValueChanged('SearchTerm')" value="sequencing" type="text" /></td> </tr> </table><script id="dxss_543298418" type="text/javascript">  </script> <span class="search-icon-container"> <a class="search-icon" href="javascript:openCategorySelector(1);"><img src="/Contents/Images/search.png" /></a> </span> </li> <li class="fl"> <div class="dxbButton_MetropolisBlue SearchButton dxbButtonSys dxbTSys" id="SearchArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="SearchArticle_I" class="dxb-hb" value="Find an Article" type="submit" name="ctl00$SearchArticle" /><span class="dx-vam">Find an Article</span> </div> </div><script id="dxss_842240986" type="text/javascript">  </script> </li> </ul> <div class="cl"></div> <div class="search-menu"> <span>Find an Article (55823063)</span>   <a href="/Categories" target="_blank">Find a Category (125)</a>   <a href="/SearchJournal" target="_blank">Find a Journal (6158)</a>   <a href="/searchscholar" target="_blank">Find a Scholar (3749)</a>   <a href="/searchacademicassistant" target="_blank">Find an Academic Assistant (18)</a> </div> <div class="search-menu" style="text-align:center;"> <span>Find an Article PDF (4649768)</span>   <a href="/TodayArticles" target="_self">Today's Articles (604)</a>   <span>Subscriber (50864)</span> </div> </div> </div> </div> <script src="/bundles/UserAcademicAchievement?v=QYKvd9c2mOpOgKt90go7osO6NdxcNzivChzWAq_gw3g1"></script> <script type="text/javascript"> $(function () { try { var sort = getQueryString2('sort'); if (sort != null && sort != '') { if ($("[field='st" + sort + "']").length) { $("[field='st" + sort + "']").addClass("sort-highlight"); } if ($("#" + sort + "sortedCheck").length) { $("#" + sort + "sortedCheck").prop("checked", true); } } $("a.readmore").click(function () { $(this).parent().toggle().next().toggle(); }); $("a.readless").click(function () { $(this).parent().toggle().prev().toggle(); }); var action = getQueryString2('action'); if (action != null && action != '') { if ($("a[name='" + action + "']").length) { $("a[name='" + action + "']").first().click(); } } InitializeResultAnalysisBtn(); } catch (e) { } try { $(".file-container-btn").each(function () { var itemCount = parseInt($(this).attr("item-count")); if (itemCount > 0) { $(this).click(function () { var controlId = $(this).attr("aria-controls"); $("#" + controlId).toggle(); var fa = $(this).children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } }); } }); InitAchievementContents(true); InitYearFacets(); setTimeout(() => setUserContainerBorder(), 1000); setTimeout(() => setUserContainerBorder(), 2000); setTimeout(() => setUserContainerBorder(), 5000); } catch (e) { } AddVisitRecord(2); }); function DeleteArticle(doi) { if (confirm("Confirm Delete the Artilce?")) { LoadingPanel.Show(); try { if (doi != '') { var uri = "/api/BpgUser/DeleteArticle?doi=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, async: false, success: function () { window.location.href = window.location.href; } }); } } catch (e) { } finally { LoadingPanel.Hide(); } } } function Refresh() { CloseEdit(); window.location.href = window.location.href; } function CloseEdit() { pcEditArticleControl.Hide(); } function EditArticle(doi) { pcEditArticleControl.SetContentUrl("/EditUserArticle?Id=" + encodeURIComponent(doi)); pcEditArticleControl.Show(); } function setUserContainerBorder() { try { var leftContainerHeight = $('.user-info-center-container .left-part').outerHeight(); var rightContainerHeight = $('.user-info-center-container .right-part').outerHeight(); if (leftContainerHeight > rightContainerHeight) { $('.user-info-center-container .left-part').css('border-right', '1px solid #C0C0C0'); $('.user-info-center-container .right-part').css('border-left', ''); } else { $('.user-info-center-container .right-part').css('border-left', '1px solid #C0C0C0'); $('.user-info-center-container .left-part').css('border-right', ''); } } catch (e) { } } function ShowUserFriendList() { var expandContainer = $(".expandUserFriend"); $(".user-friend-list").toggle(); var fa = expandContainer.children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } } function ShowUserContainerList(className, listClassName) { var expandContainer = $("." + className); $("." + listClassName).toggle(); var fa = expandContainer.children("i"); if (fa.hasClass("fa-plus")) { fa.removeClass("fa-plus"); fa.addClass("fa-minus"); } else { fa.removeClass("fa-minus"); fa.addClass("fa-plus"); } } function OpenMessage(id, friendId) { OpenFriendMessage(friendId); $("div[name='countcontainer" + id + "']").hide(); } function DeleteFriend(id) { if (confirm("Confirm Delete the Friend?")) { LoadingPanel.Show(); var uri = "/api/BpgUser/DeleteFriend?id=" + id; $.ajax({ type: "get", url: uri, async: false }).done(function () { window.location.href = window.location.href; }); } } function SelectAllFriend() { $("input[name='checkfriend']").each(function () { $(this).attr("checked", $('#selectAllFriend').prop("checked")); }); onCheckFriendClick(); } function onCheckFriendClick() { var itemArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); }); if (itemArray.length > 0) { $("#BatchMessageContainer").show(); } else { $("#BatchMessageContainer").hide(); } } function SendBatchMessages() { var itemArray = new Array(); var idArray = new Array(); $("input[name='checkfriend']:checked").each(function () { itemArray.push($(this).val()); idArray.push($(this).attr("data-id")); }); if (itemArray.length > 0) { if (itemArray.length == 1) { OpenMessage(idArray[0], itemArray[0]); } else { var friendIds = JSON.stringify(itemArray); OpenBatchFriendMessage(friendIds); } } } function ImportSingleArticle(doi, controlId) { if (doi != '') { LoadingPanel.Show(); var uri = "/api/BpgUser/ImportArticle?doiPmid=" + encodeURIComponent(doi); $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function (data) { LoadingPanel.Hide(); if (data) { alert("Import Successfully!"); var currentControl = $("#" + controlId); currentControl.parent().hide(); } }).always(function () { LoadingPanel.Hide(); }); } } function ImportAllArticles() { LoadingPanel.Show(); var term = getQueryString2('term'); var uri = "/api/BpgUser/ImportArticlesFromSearch?term=" + term; $.ajax({ type: "get", url: uri, beforeSend: function (xhr) { LoadingPanel.Show(); } }).done(function () { LoadingPanel.Hide(); alert("Imorting is executing!"); }).always(function () { LoadingPanel.Hide(); }); } </script> <input type="hidden" name="ctl00$RootHolder$RCAId" id="RCAId" /> <input type="hidden" name="ctl00$RootHolder$RCAUserType" id="RCAUserType" /> <input type="hidden" name="ctl00$RootHolder$UserId" id="UserId" /> <input type="hidden" name="ctl00$RootHolder$IsCurrentUser" id="IsCurrentUser" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div id="RootHolder_ExportContainer" class="export-container"> <div class="dxbButton_MetropolisBlue DefaultButton-Oral dxbButtonSys dxbTSys" id="RootHolder_DownloadArticle" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_DownloadArticle_I" class="dxb-hb" value="Download" type="button" name="ctl00$RootHolder$DownloadArticle" /><span class="dx-vam">Download</span> </div> </div><script id="dxss_1963926087" type="text/javascript">  </script> </div> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">2316</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (934)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (1308)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label id="RootHolder_SearchTermText" class="search-term-text">sequencing</label> </div> <div id="yearFacetContainer"> <div class="mnavbar"> <div> Year Published </div> </div> <div class="mnavbox"> <div id="yearFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('year');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refineyearcheck" target="_self">Refine</a> </div> </div> </div> <div id="jsFacetContainer"> <div class="mnavbar"> <div> Article Statistics </div> </div> <div class="mnavbox"> <div id="jsFacetItemContainer"> </div> <div class="refine-btn-container cl" name="refinejscheck"> <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejscheck" target="_self">Refine</a> </div> </div> </div> <div class="mnavbar"> <div> Ranked By </div> </div> <div class="mnavbox"> <ul class="ul sortedby-list"> <li> <input type="radio" id="aisortedCheck" onclick="SetSorted('ai')" name="sortedbycheck" value="aisorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('ai')" id="aisorted">Impact Index Per Article</a> </li> <li> <input type="radio" id="citedf6sortedCheck" onclick="SetSorted('citedf6')" name="sortedbycheck" value="citedf6sorted" /> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('citedf6')" id="citedf6sorted"> Citation(s) in <i>RCA</i> </a> </li> </ul> </div> <div id="RootHolder_ResultsAnalysisContainer"> <div class="mnavbar"> <div> Results Analysis </div> </div> <div class="mnavbox"> <ul class="ul analysis-list"> <li> <input type="checkbox" id="YearAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="year" />  <label for="YearAnalysis">Year Published Analysis</label> </li> <li> <input type="checkbox" id="ArticleTypeAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="at" />  <label for="ArticleTypeAnalysis">Article Type Analysis</label> </li> <li> <input type="checkbox" id="JournalTitleAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="journal" />  <label for="JournalTitleAnalysis">Publication Title Analysis</label> </li> <li> <input type="checkbox" id="CategoriesAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="subject" />  <label for="CategoriesAnalysis">Category Analysis</label> </li> </ul> <div class="refine-btn-container cl" name="analysis-check-btn-container"> <a href="javascript:ResultAnalysis();" class="refine-link-btn refine-link-btn-right" target="_self">Results Analysis</a> </div> </div> </div> <div class="refine-btn-container-n cl" id="showFacetsContainer"> <a href="javascript:InitAllFacets();" class="refine-link-btn-right" target="_self">Show more</a> </div> <div id="facetsContainer" class="cl" style="display: none;"> <div class="mnavbar" id="PubDateFacetTitle"> <div> Indexed Articles </div> </div> <div class="mnavbox" id="PubDateFacetContainer"> <ul class="ul sortedby-list"> <li> <a href="javascript:SubmitSingleFacetSearch('create','6');">Today (<span id="indexCount6"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','5');">Yesterday (<span id="indexCount5"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','4');">This Week (<span id="indexCount4"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','3');">Last Week (<span id="indexCount3"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','2');">Current Month (<span id="indexCount2"></span>)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('create','1');">Last Month (<span id="indexCount1"></span>)</a> </li> </ul> </div> <div id="journalFacetContainer"> <div class="mnavbar"> <div> Publication Titles </div> </div> <div class="mnavbox"> <div id="journalFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('journal');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinejournalcheck" target="_self">Refine</a> </div> </div> </div> <div id="fundFacetContainer"> <div class="mnavbar"> <div> Grant Agencies </div> </div> <div class="mnavbox"> <div id="fundFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('fund');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinefundcheck" target="_self">Refine</a> </div> </div> </div> <div id="subjectFacetContainer"> <div class="mnavbar"> <div> Category </div> </div> <div class="mnavbox"> <div id="subjectFacetItemContainer"> </div> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('subject');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refinesubjectcheck" target="_self">Refine</a> </div> </div> </div> </div> </div> <div class="right-part"> <div class="mnavbar" style="margin-bottom: 0.625rem;"> <div> Journal Articles </div> </div> <table class="article-result-list cl"> <thead> <tr> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span> </td> <td> <span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Citation Analysis</span> </td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width: 40px; text-align: center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Padmaswari MH</b>, Bulliard G, Agrawal S, Jia MS, Khadgi S, Murach KA, Nelson CE. Precision and efficacy of RNA-guided DNA integration in high-expressing muscle loci. <em>MOLECULAR THERAPY. NUCLEIC ACIDS</em> 2024;<b>35</b>:102320. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39398225' target='_blank'>39398225</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466678' target='_blank'>PMC11466678</a> DOI: <a href='https://dx.doi.org/10.1016/j.omtn.2024.102320' target='_blank'>10.1016/j.omtn.2024.102320</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.omtn.2024.102320','39398225', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.omtn.2024.102320' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/bff218cd254883a7d85c7583f120a06c/main.PMC11466678.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1016/j.omtn.2024.102320');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/15/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1016/j.omtn.2024.102320" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Gene replacement therapies primarily rely on adeno-associated virus (AAV) vectors for transgene expression. However, episomal expression can decline over time due to vector loss or epigenetic silencing. CRISPR-based integration methods offer promise for long-term transgene insertion. While the development of transgene integration methods has made substantial progress, identifying optimal insertion loci remains challenging. Skeletal muscle is a promising tissue for gene replacement owing to low invasiveness of intramuscular injections, relative proportion of body mass, the multinucleated nature of muscle, and the potential for reduced adverse effects. Leveraging endogenous promoters in skeletal muscle, we evaluated two highly expressing loci using homology-independent targeted integration (HITI) to integrate reporter or therapeutic genes in mouse myoblasts and skeletal muscle tissue. We hijacked the muscle creatine kinase (Ckm) and myoglobin (Mb) promoters by co-delivering CRISPR-Cas9 and a donor plasmid with promoterless constructs encoding green fluorescent protein (GFP) or human Factor IX (hFIX). Additionally, we deeply profiled our genome and transcriptome outcomes from targeted integration and evaluated the safety of the proposed sites. This study introduces a proof-of-concept technology for achieving high-level therapeutic gene expression in skeletal muscle, with potential applications in targeted integration-based medicine and synthetic biology. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CRISPR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CRISPR</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MT%3a+RNA%2fDNA+Editing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MT: RNA/DNA Editing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22endogenous-promoter%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">endogenous-promoter</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gene+editing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gene editing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22homology-independent+targeted+integration+(HITI)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">homology-independent targeted integration (HITI)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22integration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">integration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22muscle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">muscle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22muscle-specific+promoters%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">muscle-specific promoters</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22overexpression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">overexpression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width: 40px; text-align: center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Feng J</b>, Ren Q, Xie A, Jiang Z, Liu Y. High-resolution melting analysis to authenticate deer-derived materials in processed products in China using a cytochrome oxidase I mini-barcode. <em>JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE</em> 2024;<b>104</b>:9390-9398. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39051761' target='_blank'>39051761</a> DOI: <a href='https://dx.doi.org/10.1002/jsfa.13761' target='_blank'>10.1002/jsfa.13761</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/jsfa.13761','39051761', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(2);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/jsfa.13761' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1002/jsfa.13761" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Deer-derived materials (antler, venison, fetus, penis, bone, tail, and others) are some of the most valuable traditional animal-based medicinal and food materials in China. In production, processing, and trade, the quality of deer products varies. The market is confusing, and counterfeit and shoddy products are common. There is an urgent need to establish an accurate identification method. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Two pairs of primers suitable for identifying deer-derived medicinal materials were obtained by screening the cytochrome oxidase I (COI) sequences of 18 species from nine genera of the deer family. The two primers were used to identify the species and adulteration of 22 batches of commercially available deer-derived products with a mini-barcode combining high-resolution melting (HRM) technology and methodical investigation. Deer-derived materials (sika and red deer) were correctly identified by species using varying DNA amounts (1 to 500 ng). The two pairs of primers COI-1FR and COI-2FR yielded melting temperatures (Tm) of 80.55 to 81.00 °C and 82.00 to 82.50 °C for sika deer, and 81.00 to 82.00 °C and 81.40 to 82.00 °C for red deer. Twenty-two batches of commercially available samples were analyzed by HRM analysis and conventional amplification sequencing, and it was found that the species samples had an error rate of species labeling of 31.8%. Four batches of samples were identified as mixed (adulterated) in the HRM analysis. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">The combination of DNA mini-barcode with HRM analysis facilitated the accurate identification of species of deer-derived materials, especially the identification of samples in an adulterated mixed state. © 2024 Society of Chemical Industry. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA+mini%e2%80%90barcode%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA mini‐barcode</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cytochrome+oxidase+I%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cytochrome oxidase I</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22deer%e2%80%90derived+materials%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">deer‐derived materials</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22high+resolution+melting%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">high resolution melting</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Deer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Deer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Electron+Transport+Complex+IV%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Electron Transport Complex IV/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA+Barcoding%2c+Taxonomic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA Barcoding, Taxonomic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antlers%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antlers/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transition+Temperature%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transition Temperature</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Food+Contamination%2fanalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Food Contamination/analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA%2fanalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA/analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bone+and+Bones%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bone and Bones/chemistry</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hainan+Province+Science+and+Technology+Special+Fund+Program%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ZDKJ2021034 Hainan Province Science and Technology Special Fund Program</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wanning+City+Scientific+Research+Program%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2022wnkj10 Wanning City Scientific Research Program</a></li></ul> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Campey A</b>, Łapińska U, Chait R, Tsaneva-Atanasova K, Pagliara S. Antibiotic resistant bacteria survive treatment by doubling while shrinking. <em class='incite-journal-name' onclick='ShowInCiteJournal(16510);'>mBio</em> 2024:e0237524. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39565111' target='_blank'>39565111</a> DOI: <a href='https://dx.doi.org/10.1128/mbio.02375-24' target='_blank'>10.1128/mbio.02375-24</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1128/mbio.02375-24','39565111', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1128/mbio.02375-24' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(16510);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/21/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1128/mbio.02375-24" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Many antibiotics that are used in healthcare, farming, and aquaculture end up in environments with different spatial structures that might promote heterogeneity in the emergence of antibiotic resistance. However, the experimental evolution of microbes at sub-inhibitory concentrations of antibiotics has been mainly carried out at the population level which does not allow capturing single-cell responses to antibiotics. Here, we investigate and compare the emergence of resistance to ciprofloxacin in Escherichia coli in well-mixed and structured environments using experimental evolution, genomics, and microfluidics-based time-lapse microscopy. We discover that resistance to ciprofloxacin and cross-resistance to other antibiotics is stronger in the well-mixed environment due to the emergence of target mutations, whereas efflux regulator mutations emerge in the structured environment. The latter mutants also harbor sub-populations of persisters that survive high concentrations of ciprofloxacin that inhibit bacterial growth at the population level. In contrast, genetically resistant bacteria that display target mutations also survive high concentrations of ciprofloxacin that inhibit their growth via population-level antibiotic tolerance. These resistant and tolerant bacteria keep doubling while shrinking in size in the presence of ciprofloxacin and regain their original size after antibiotic removal, which constitutes a newly discovered phenotypic response. This new knowledge sheds light on the diversity of strategies employed by bacteria to survive antibiotics and poses a stepping stone for understanding the link between mutations at the population level and phenotypic single-cell responses. </div><div class="abstract-label">IMPORTANCE</div><div class="abstract-content">The evolution of antimicrobial resistance poses a pressing challenge to global health with an estimated 5 million deaths associated with antimicrobial resistance every year globally. Here, we investigate the diversity of strategies employed by bacteria to survive antibiotics. We discovered that bacteria evolve genetic resistance to antibiotics while simultaneously displaying tolerance to very high doses of antibiotics by doubling while shrinking in size. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22antibiotic+tolerance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">antibiotic tolerance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22antimicrobial+resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">antimicrobial resistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22efflux%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">efflux</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22environmental+structure%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">environmental structure</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22evolution%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">evolution</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microfluidics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microfluidics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mutations%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mutations</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22persisters%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">persisters</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22single-cell+analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">single-cell analysis</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Chen Y</b>, Tang Y, Zhu T, Li F, Luo J, Chen J, Tan Y, Wang T, Peng J, Jiang G, Li J. Dynamic PAH-Related Changes: A Dataset of tRNA-Derived Small RNA Transcriptome Across Multiple Organs. <em class='incite-journal-name' onclick='ShowInCiteJournal(21040);'>Sci Data</em> 2024;<b>11</b>:1257. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39567524' target='_blank'>39567524</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579324' target='_blank'>PMC11579324</a> DOI: <a href='https://dx.doi.org/10.1038/s41597-024-04115-0' target='_blank'>10.1038/s41597-024-04115-0</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41597-024-04115-0','39567524', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(4);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41597-024-04115-0' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(21040);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/22/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1038/s41597-024-04115-0" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary disease characterized by elevated pulmonary artery pressure and cardiac dysfunction, often leading to heart failure and even death. Despite the complexity of its mechanisms, the molecular basis of PAH remains unclear. tRNA-derived small RNAs (tsRNAs) are noncoding RNAs that play regulatory roles in various diseases. We collected plasma samples from PAH patients and healthy controls for small RNA microarray, and we established a monocrotaline-induced PAH rat model to collect right ventricular and lung tissues for tsRNA sequencing. Our analysis revealed 2,716 unique tsRNAs in human plasma and 4,733 in rat tissues, with a 7.84% overlap. Additionally, 204 tsRNAs were highly conserved across plasma, lung tissue, and right ventricle samples. The reproducibility of the expression profiles was confirmed through Pearson correlation and principal component analysis. KEGG pathway enrichment analysis indicated that tsRNAs are involved in key pathways, such as the MAPK and cancer signalling pathways. These datasets offer valuable insights for researching the epigenetic mechanisms underlying PAH and potential therapeutic targets. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cardiovascular+diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cardiovascular diseases</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Transfer%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Transfer/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rats%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rats</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcriptome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcriptome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pulmonary+Arterial+Hypertension%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pulmonary Arterial Hypertension/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Small+Untranslated%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Small Untranslated/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Natural+Science+Foundation+of+Hunan+Province+(2022JJ30067)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Natural Science Foundation of Hunan Province (2022JJ30067)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Clinical+Key+Specialty+Construction+Project+Cardiovascular+Department+(Cardiopulmonary+Function+Rehabilitation+Direction)+(Z2023123)+Renshu+Fund+Project+of+Hunan+Provincial+People%e2%80%99s+Hospital+(RS2022A12)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Clinical Key Specialty Construction Project Cardiovascular Department (Cardiopulmonary Function Rehabilitation Direction) (Z2023123) Renshu Fund Project of Hunan Provincial People’s Hospital (RS2022A12)</a></li></ul> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Calewaert A</b>, Palarea-Albaladejo J, Coultous R, Capewell P, Hanks E, Decloedt A, van Loon G. Comparison of serum microRNA in healthy horses and horses with moderate to severe mitral valve regurgitation using a commercially available canine cardiac panel. <em class='incite-journal-name' onclick='ShowInCiteJournal(8663);'>Equine Vet J</em> 2024. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39567225' target='_blank'>39567225</a> DOI: <a href='https://dx.doi.org/10.1111/evj.14434' target='_blank'>10.1111/evj.14434</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/evj.14434','39567225', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/evj.14434' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8663);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1111/evj.14434" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">MicroRNA (miRNA) has previously been used as a biomarker for cardiac disease in humans and dogs, however, studies in horses are not yet available. </div><div class="abstract-label">OBJECTIVES</div><div class="abstract-content">To determine if adult horses with moderate or severe mitral valve regurgitation have a different serum miRNA expression profile compared to healthy controls. </div><div class="abstract-label">STUDY DESIGN</div><div class="abstract-content">Retrospective cross-sectional. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Serum samples from 77 adult horses with moderate or severe mitral valve regurgitation and 77 healthy control horses were analysed using a commercial cardiac disease-specific miRNA panel previously used in dogs. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The commercial canine cardiac miRNA panel had low discriminatory power as a biomarker for mitral valve regurgitation in adult horses. Sensitivity was 0.58 (95% Cl: 0.47-0.69) and specificity 0.57 (95% Cl: 0.46-0.68). </div><div class="abstract-label">MAIN LIMITATIONS</div><div class="abstract-content">Clinical data were extracted retrospectively and currently there is no well-established criteria for grading mitral regurgitation in horses; there were few severe mitral regurgitation cases and the pathogenesis of mitral regurgitation was not considered. Controls were not matched by age, breed or sex. An assay developed for use in dogs was used. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Despite strong miRNA conservation across species, the commercially available canine cardiac miRNA panel failed as biomarker for mitral valve regurgitation in adult horses. Further research is needed to determine if an equine specific panel can be developed that performs better as biomarker for cardiac disease in horses. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">biomarker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22echocardiography%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">echocardiography</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22equine+cardiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">equine cardiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22horse%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">horse</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22valvular+regurgitation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">valvular regurgitation</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Hu H</b>, Quon G. scPair: Boosting single cell multimodal analysis by leveraging implicit feature selection and single cell atlases. <em class='incite-journal-name' onclick='ShowInCiteJournal(17180);'>Nat Commun</em> 2024;<b>15</b>:9932. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39548084' target='_blank'>39548084</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568318' target='_blank'>PMC11568318</a> DOI: <a href='https://dx.doi.org/10.1038/s41467-024-53971-2' target='_blank'>10.1038/s41467-024-53971-2</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41467-024-53971-2','39548084', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(6);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41467-024-53971-2' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17180);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/17/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1038/s41467-024-53971-2" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Multimodal single-cell assays profile multiple sets of features in the same cells and are widely used for identifying and mapping cell states between chromatin and mRNA and linking regulatory elements to target genes. However, the high dimensionality of input features and shallow sequencing depth compared to unimodal assays pose challenges in data analysis. Here we present scPair, a multimodal single-cell data framework that overcomes these challenges by employing an implicit feature selection approach. scPair uses dual encoder-decoder structures trained on paired data to align cell states across modalities and predict features from one modality to another. We demonstrate that scPair outperforms existing methods in accuracy and execution time, and facilitates downstream tasks such as trajectory inference. We further show scPair can augment smaller multimodal datasets with larger unimodal atlases to increase statistical power to identify groups of transcription factors active during different stages of neural differentiation. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22machine+learning%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">machine learning</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22data+integration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">data integration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22computational+models%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">computational models</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bioinformatics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bioinformatics</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Single-Cell+Analysis%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Single-Cell Analysis/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chromatin%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chromatin/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chromatin%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chromatin/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+Factors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription Factors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Messenger%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Messenger/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Messenger%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Messenger/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Algorithms%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Algorithms</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Differentiation</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIMH+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DP2 MH129987 NIMH NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NICHD+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P50 HD103526 NICHD NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NSF+%7c+BIO+%7c+Division+of+Biological+Infrastructure+(DBI)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">1846559 NSF | BIO | Division of Biological Infrastructure (DBI)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22U.S.+Department+of+Health+%26amp%3b+Human+Services+%7c+NIH+%7c+National+Institute+of+Mental+Health+(NIMH)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22U.S.+Department+of+Health+%26amp%3b+Human+Services+%7c+NIH+%7c+Eunice+Kennedy+Shriver+National+Institute+of+Child+Health+and+Human+Development+(NICHD)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)</a></li></ul> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Beaudry MS</b>, Bhuiyan MIU, Glenn TC. Enriching the future of public health microbiology with hybridization bait capture. <em class='incite-journal-name' onclick='ShowInCiteJournal(6499);'>Clin Microbiol Rev</em> 2024:e0006822. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39545729' target='_blank'>39545729</a> DOI: <a href='https://dx.doi.org/10.1128/cmr.00068-22' target='_blank'>10.1128/cmr.00068-22</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1128/cmr.00068-22','39545729', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1128/cmr.00068-22' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(6499);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/17/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1128/cmr.00068-22" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">SUMMARYPublic health microbiology focuses on microorganisms and infectious agents that impact human health. For years, this field has relied on culture or molecular methods to investigate complex samples of public health importance. However, with the increase in accuracy and decrease in sequencing cost over the last decade, there has been a transition to the use of next-generation sequencing in public health microbiology. Nevertheless, many available sequencing methods (e.g., shotgun metagenomics and amplicon sequencing) do not work well in complex sample types, require deep sequencing, or have inherent biases associated with them. Hybridization bait capture, also known as target enrichment, brings in solutions for such limitations. It is an increasingly popular technique to simultaneously characterize many thousands of genetic elements while reducing the amount of sequencing needed (thereby reducing the sequencing costs). Here, we summarize the concept of hybridization bait capture for public health, reviewing a total of 35 bait sets designed in six key topic areas for public health microbiology [i.e., antimicrobial resistance (AMR), bacteria, fungi, parasites, vectors, and viruses], and compare hybridization bait capture to previously relied upon methods. Furthermore, we provide an in-depth comparison of the three most popular bait sets designed for AMR by evaluating each of them against three major AMR databases: Comprehensive Antibiotic Resistance Database, Microbial Ecology Group Antimicrobial Resistance Database, and Pathogenicity Island Database. Thus, this article provides a review of hybridization bait capture for public health microbiologists. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Illumina+sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Illumina sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SARS-CoV-2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SARS-CoV-2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22antimicrobial+resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">antimicrobial resistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bacteria%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bacteria</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22capture%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">capture</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22enrichment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">enrichment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22fungi%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">fungi</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hybridization+bait+capture%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hybridization bait capture</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22long-read+sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">long-read sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22metagenomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">metagenomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22parasites%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">parasites</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22public+health%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">public health</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22vectors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">vectors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22viruses%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">viruses</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Fang S</b>, Luo S, Jin S, Liu J, Li J, Zhang Y, Liu Z, Yuan M, Yan D, Dong X, Yang R. Transcriptomic profiling of backfat and muscle in Lijiang pigs with divergent body size across growth stages. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2024;<b>14</b>:27677. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39532937' target='_blank'>39532937</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557953' target='_blank'>PMC11557953</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-024-78054-6' target='_blank'>10.1038/s41598-024-78054-6</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-024-78054-6','39532937', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(8);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-024-78054-6' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1038/s41598-024-78054-6" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Backfat thickness is an important economic trait that affects pork quality and flavor. The Lijiang pig (LJP), a local breed in Yunnan province, China, exhibits variations in growth and body composition. However, the molecular basis for these variations is unclear. This study aimed to analyze transcriptome profiles of backfat at different growth stages in LJP with discrepant body size: two months (M2), four months, and six months. Firstly, we analyzed the gene expression differences and discovered a significantly highest number of differentially expressed genes (DEGs) at the M2 stage. Secondly, we identified four gene profiles with reverse expression trends in LJP populations with different body sizes, and the related genes mainly associated with immune response functionality. Thirdly, we observed a lower correlation in LJP with large body size at the M2 stage, with a specific enrichment of DEGs with high genetic differentiation related to neural activity. Finally, we correlated transcriptome profiles of muscle and backfat and discovered the lowest correlation at the M2 stage. Highly correlated genes exhibited more significant differences and were prominently enriched for immune response processes. This study unveils candidate genes linked to backfat growth in LJP, emphasizing the specificity of the early growth stage of backfat. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22animal+breeding%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">animal breeding</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22functional+genomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">functional genomics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gene+expression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gene expression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gene+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gene regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Swine%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Swine/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Swine%2fgrowth+%26amp%3b+development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Swine/growth & development</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Profiling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Profiling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Body+Size%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Body Size/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcriptome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcriptome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adipose+Tissue%2fgrowth+%26amp%3b+development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adipose Tissue/growth & development</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscle%2c+Skeletal%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscle, Skeletal/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Muscle%2c+Skeletal%2fgrowth+%26amp%3b+development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Muscle, Skeletal/growth & development</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Body+Composition%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Body Composition/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">32060736 National Natural Science Foundation of China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yunnan+Academician+(Expert)+Workstation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">202105AF150068 Yunnan Academician (Expert) Workstation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yunnan+Fundamental+Research+Project%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">202101AT070209 Yunnan Fundamental Research Project</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yunnan+Agricultural+Fundamental+Research+Joint+Project%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">202301BD070001-177 Yunnan Agricultural Fundamental Research Joint Project</a></li></ul> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width: 40px; text-align: center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>McAfee JL</b>, Alban TJ, Makarov V, Rupani A, Parthasarathy PB, Tu Z, Ronen S, Billings SD, Diaz CM, Chan TA, Ko JS. Genomic landscape of superficial malignant peripheral nerve sheath tumor. <em class='incite-journal-name' onclick='ShowInCiteJournal(15781);'>J Transl Med</em> 2024:102183. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39532239' target='_blank'>39532239</a> DOI: <a href='https://dx.doi.org/10.1016/j.labinv.2024.102183' target='_blank'>10.1016/j.labinv.2024.102183</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.labinv.2024.102183','39532239', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.labinv.2024.102183' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(15781);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1016/j.labinv.2024.102183" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Superficial malignant peripheral nerve sheath tumors (SF-MPNSTs) are rare cancers and can be difficult to distinguish from spindle cell (SCM) or desmoplastic (DM) melanomas. Their biology is poorly understood. We performed whole-exome sequencing (WES) and RNA sequencing (RNA-seq) on SF-MPNST (n=8) and compared these to cases of SCM (n=7), DM (n=8), and deep MPNST (D-MPNST, n=8). Immunohistochemical staining for H3K27me3 and PRAME was also performed. SF-MPNST demonstrated intermediate features between D-MPNST and melanoma. Patients were younger than those with melanoma, and older than those with D-MPNST; outcome was worse and better respectively. SF-MPNST tumor mutational burden (TMB) was higher than D-MPNST and lower than melanoma; differences were significant only between SF-MPNST and SCM (p = 0.0454) and between D-MPNST and SCM (p = 0.001, Dunn's Kruskal-Wallis post-hoc test). Despite having an overlapping mutational profile in some common cancer-associated genes, the COSMIC mutational signatures clustered DM and SCM together with ultraviolet light exposure signatures (SBS7a, 7b), and SF- and D-MPNST together with defective DNA base excision repair (SBS30, 36). RNA-seq revealed differentially expressed genes between SF-MPNST and SCM (1670 genes), DM (831 genes), and D-MPNST (614 genes), some of which hold promise for development as immunohistochemical markers (SOX8, PLCH1) or aids (MLPH, CALB2, SOX11, TBX4). H3K27me3 immunoreactivity was diffusely lost in most D-MPNSTs (7/8, 88%), but showed variable and patchy loss in SF-MPNSTs (2/8, 25%). PRAME was entirely negative in the majority (0+ in 20/31, 65%), including 11/15 melanomas, and showed no significant difference between groups (p=0.105, Kruskal-Wallis test). Expression of immune cell transcripts was upregulated in melanomas relative to MPNSTs. Next-generation sequencing revealed multiple differential features between SF- MPNST, D-MPNST, SCM, and DM, including tumor mutation burden, mutational signatures, and differentially expressed genes. These findings help advance our understanding of disease pathogenesis and improve diagnostic modalities. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22desmoplastic+melanoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">desmoplastic melanoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22molecular%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">molecular</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22spindle+cell+melanoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">spindle cell melanoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22superficial+malignant+peripheral+nerve+sheath+tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">superficial malignant peripheral nerve sheath tumor</a></li></ul> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Roesel T</b>, Cao C, Bada Juarez JF, Dal Peraro M, Roke S. Dissecting the Membrane Association Mechanism of Aerolysin Pores at Femtomolar Concentrations Using Water as a Probe. <em>NANO LETTERS</em> 2024;<b>24</b>:13888-13894. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39469905' target='_blank'>39469905</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544699' target='_blank'>PMC11544699</a> DOI: <a href='https://dx.doi.org/10.1021/acs.nanolett.4c00035' target='_blank'>10.1021/acs.nanolett.4c00035</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1021/acs.nanolett.4c00035','39469905', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(10);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1021/acs.nanolett.4c00035' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/30/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1021/acs.nanolett.4c00035" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Aerolysin is a bacterial toxin that forms transmembrane pores at the host plasma membrane and has a narrow internal diameter and great stability. These assets make it a highly promising nanopore for detecting biopolymers such as nucleic acids and peptides. Although much is known about aerolysin from a microbiological and structural perspective, its membrane association and pore-formation mechanism are not yet fully understood. Here, we used angle-resolved second harmonic scattering (AR-SHS) and single-channel current measurements to investigate how wild-type (wt) aerolysin and its mutants interact with liposomes in aqueous solutions at femtomolar concentrations. Our AR-SHS experiments were sensitive enough to detect changes in the electrostatic properties of membrane-bound aerolysin, which were induced by variations in pH levels. We reported for the first time the membrane binding affinity of aerolysin at different stages of the pore formation mechanism: while wt aerolysin has a binding affinity as high as 20 fM, the quasi-pore and the prepore states show gradually decreasing membrane affinities, incomplete insertion, and a pore opening signature. Moreover, we quantitatively characterized the membrane affinity of mutants relevant for applications to nanopore sensing. Our study provides a label-free method for efficiently screening biological pores suitable for conducting molecular sensing and sequencing measurements as well as for probing pore-forming processes. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22aerolysin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">aerolysin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22angle-resolved+second+harmonic+scattering%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">angle-resolved second harmonic scattering</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22molecular+sensing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">molecular sensing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nanopores%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nanopores</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pore+Forming+Cytotoxic+Proteins%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pore Forming Cytotoxic Proteins/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacterial+Toxins%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacterial Toxins/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacterial+Toxins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacterial Toxins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanopores%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanopores</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Water%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Water/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Membrane%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Membrane/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Membrane%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Membrane/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liposomes%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liposomes/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hydrogen-Ion+Concentration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hydrogen-Ion Concentration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Static+Electricity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Static Electricity</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22H2020+European+Research+Council%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">H2020 European Research Council</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Julia+Jacobi+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Julia Jacobi Foundation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Novartis+Stiftung%c3%82%c2%a0f%c3%83%c2%bcr%c3%82%c2%a0Medizinisch-Biologische+Forschung%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Novartis StiftungÂ fÃ¼rÂ Medizinisch-Biologische Forschung</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Schweizerischer+Nationalfonds+zur+F%c3%83%c2%b6rderung+der+Wissenschaftlichen+Forschung%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Schweizerischer Nationalfonds zur FÃ¶rderung der Wissenschaftlichen Forschung</a></li></ul> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Shojaeisaadi H</b>, Schoenrock A, Meier MJ, Williams A, Norris JM, Palmer ND, Yauk CL, Marchetti F. Mutational signature analyses in multi-child families reveal sources of age-related increases in human germline mutations. <em class='incite-journal-name' onclick='ShowInCiteJournal(6800);'>Commun Biol</em> 2024;<b>7</b>:1451. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39506086' target='_blank'>39506086</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541588' target='_blank'>PMC11541588</a> DOI: <a href='https://dx.doi.org/10.1038/s42003-024-07140-2' target='_blank'>10.1038/s42003-024-07140-2</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s42003-024-07140-2','39506086', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(11);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s42003-024-07140-2' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(6800);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/08/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1038/s42003-024-07140-2" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Whole-genome sequencing studies of parent-offspring trios have provided valuable insights into the potential impact of de novo mutations (DNMs) on human health and disease. However, the molecular mechanisms that drive DNMs are unclear. Studies with multi-child families can provide important insight into the causes of inter-family variability in DNM rates but they are highly limited. We characterized 2479 de novo single nucleotide variants (SNVs) in 13 multi-child families of Mexican-American ethnicity. We observed a strong paternal age effect on validated de novo SNVs with extensive inter-family variability in the yearly rate of increase. Children of older fathers showed more C > T transitions at CpG sites than children from younger fathers. Validated SNVs were examined against one cancer (COSMIC) and two non-cancer (human germline and CRISPR-Cas 9 knockout of human DNA repair genes) mutational signature databases. These analyses suggest that inaccurate DNA mismatch repair during repair initiation and excision processes, along with DNA damage and replication errors, are major sources of human germline de novo SNVs. Our findings provide important information for understanding the potential sources of human germline de novo SNVs and the critical role of DNA mismatch repair in their genesis. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Germ-Line+Mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Germ-Line Mutation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymorphism%2c+Single+Nucleotide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymorphism, Single Nucleotide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Paternal+Age%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Paternal Age</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mexican+Americans%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mexican Americans/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Whole+Genome+Sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Whole Genome Sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Age+Factors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Age Factors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA+Mutational+Analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA Mutational Analysis</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22U.S.+Department+of+Health+%26+Human+Services+%7c+NIH+%7c+National+Heart%2c+Lung%2c+and+Blood+Institute+(NHLBI)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HL060944, HL061019 and HL060919 U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDDK+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 DK085175 NIDDK NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gouvernement+du+Canada+%7c+Health+Canada+(Sant%c3%a9+Canada)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genomics Research and Development Initiative Gouvernement du Canada | Health Canada (Santé Canada)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NHLBI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 HL060944 NHLBI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22U.S.+Department+of+Health+%26+Human+Services+%7c+NIH+%7c+National+Institute+of+Diabetes+and+Digestive+and+Kidney+Diseases+(National+Institute+of+Diabetes+%26+Digestive+%26+Kidney+Diseases)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DK085175 and DK118062 U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NHLBI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 HL061019 NHLBI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Canada+Research+Chairs+(Chaires+de+recherche+du+Canada)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CRC-2020-00060 Canada Research Chairs (Chaires de recherche du Canada)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDDK+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 DK118062 NIDDK NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NHLBI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 HL060919 NHLBI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wellcome+Trust%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wellcome Trust</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NHGRI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 HG007112 NHGRI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22U.S.+Department+of+Health+%26+Human+Services+%7c+NIH+%7c+National+Heart%2c+Lung%2c+and+Blood+Institute+(NHLBI)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HG007112 U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22U.S.+Department+of+Health+%26amp%3b+Human+Services+%7c+NIH+%7c+National+Heart%2c+Lung%2c+and+Blood+Institute+(NHLBI)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22U.S.+Department+of+Health+%26amp%3b+Human+Services+%7c+NIH+%7c+National+Institute+of+Diabetes+and+Digestive+and+Kidney+Diseases+(National+Institute+of+Diabetes+%26amp%3b+Digestive+%26amp%3b+Kidney+Diseases)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)</a></li></ul> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Hackman J</b>, Hibberd ML, Swarthout TD, Hinds J, Ashall J, Sheppard C, Tonkin-Hill G, Gould K, Brown C, Msefula J, Mataya AA, Toizumi M, Yoshida LM, French N, Heyderman RS, Flasche S, Kwambana B, Hué S. Evaluating methods for identifying and quantifying <i>Streptococcus pneumoniae</i> co-colonization using next-generation <span class="highlight-field">sequencing</span> data. <em class='incite-journal-name' onclick='ShowInCiteJournal(16915);'>Microbiol Spectr</em> 2024:e0364323. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39499074' target='_blank'>39499074</a> DOI: <a href='https://dx.doi.org/10.1128/spectrum.03643-23' target='_blank'>10.1128/spectrum.03643-23</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1128/spectrum.03643-23','39499074', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1128/spectrum.03643-23' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(16915);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/02/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/07/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1128/spectrum.03643-23" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Detection of multiple pneumococcal serotype carriage can enhance monitoring of pneumococcal vaccine impact, particularly among high-burden childhood populations. We assessed methods for identifying co-carriage of pneumococcal serotypes from whole-genome sequences. Twenty-four nasopharyngeal samples were collected during community carriage surveillance from healthy children in Blantyre, Malawi, which were then serotyped by microarray. Pneumococcal DNA from culture plate sweeps were sequenced using Illumina MiSeq, and genomic serotyping was carried out using SeroCall and PneumoKITy. Their sensitivity was calculated in reference to the microarray data. Local maxima in the single-nucleotide polymorphism (SNP) density distributions were assessed for their correspondence to the relative abundance of serotypes. Across the 24 individuals, the microarray detected 77 non-unique serotypes, of which 42 occurred at high relative abundance (>10%) (per individual, median, 3; range, 1-6 serotypes). The average sequencing depth was 57X (range: 21X-88X). The sensitivity of SeroCall for identifying high-abundance serotypes was 98% (95% CI, 0.87-1.00), 20% (0.08-0.36) for low abundance (<10%), and 62% (0.50-0.72) overall. PneumoKITy's sensitivity was 86% (0.72-0.95), 20% (0.06-0.32), and 56% (0.42-0.65), respectively. Local maxima in the SNP frequency distribution were highly correlated with the relative abundance of high-abundance serotypes. Six samples were resequenced, and the pooled runs had an average fourfold increase in sequencing depth. This allowed genomic serotyping of two of the previously undetectable seven low-abundance serotypes. Genomic serotyping is highly sensitive for the detection of high-abundance serotypes in samples with co-carriage. Serotype-associated reads may be identified through SNP frequency, and increased read depth can increase sensitivity for low-abundance serotype detection.IMPORTANCEPneumococcal carriage is a prerequisite for invasive pneumococcal disease, which is a leading cause of childhood pneumonia. Multiple carriage of unique pneumococcal serotypes at a single time point is prevalent among high-burden childhood populations. This study assessed the sensitivity of different genomic serotyping methods for identifying pneumococcal serotypes during co-carriage. These methods were evaluated against the current gold standard for co-carriage detection. The results showed that genomic serotyping methods have high sensitivity for detecting high-abundance serotypes in samples with co-carriage, and increasing sequencing depth can increase sensitivity for low-abundance serotypes. These results are important for monitoring vaccine impact, which aims to reduce the prevalence of specific pneumococcal serotypes. By accurately detecting and identifying multiple pneumococcal serotypes in carrier populations, we can better evaluate the effectiveness of vaccination programs. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Africa%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Africa</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Streptococcus+pneumoniae%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Streptococcus pneumoniae</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22co-carriage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">co-carriage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microarray%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microarray</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pneumococcus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pneumococcus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22serotyping%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">serotyping</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Bardill JR</b>, Karimpour-Fard A, Breckenfelder CC, Sucharov CC, Eason CR, Gallagher LT, Khailova L, Wright CJ, Gien J, Galan HL, Derderian SC. microRNAs in congenital diaphragmatic hernia: insights into prenatal and perinatal biomarkers and altered molecular pathways. <em class='incite-journal-name' onclick='ShowInCiteJournal(162940);'>Am J Obstet Gynecol MFM</em> 2024;<b>6</b>:101535. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39505208' target='_blank'>39505208</a> DOI: <a href='https://dx.doi.org/10.1016/j.ajogmf.2024.101535' target='_blank'>10.1016/j.ajogmf.2024.101535</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ajogmf.2024.101535','39505208', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ajogmf.2024.101535' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(162940);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/08/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1016/j.ajogmf.2024.101535" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Congenital diaphragmatic hernia (CDH) is characterized by a diaphragmatic defect, leading to herniation of abdominal organs into the chest, lung compression, and impaired lung development, often resulting in pulmonary hypertension and lung hypoplasia. Prenatal imaging techniques like ultrasound and MRI provide anatomical predictors of outcomes, but their limitations necessitate novel biomarkers for better prognostic accuracy. </div><div class="abstract-label">OBJECTIVE</div><div class="abstract-content">This study aims to identify unique circulating maternal, fetal, and neonatal microRNAs (miRNAs) that can distinguish CDH pregnancies from healthy controls and assess their potential as markers of disease severity. </div><div class="abstract-label">STUDY DESIGN</div><div class="abstract-content">We conducted a prospective study involving third-trimester maternal blood, amniotic fluid, cord blood, and neonatal blood samples from pregnancies complicated by CDH and healthy controls. miRNA expression was analyzed using RNA-sequencing, and random forest analysis identified miRNAs distinguishing CDH survivors from nonsurvivors. Pathway enrichment analyses were performed to explore the biological relevance of differentially expressed miRNAs. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Significant miRNA expression differences were observed between CDH and control samples across all sample types. In infant blood, 148 miRNAs were up-regulated, and 36 were down-regulated in CDH cases. Pathway analysis revealed that dysregulated miRNAs in CDH targeted pathways related to protein binding, transcription regulation, and signaling pathways implicated in pulmonary hypertension and lung hypoplasia. Random forest analysis identified miRNAs in maternal blood (miR-7850-5p_L-1R+2, miR-942-3p, and miR-197-3p) that distinguished CDH survivors from nonsurvivors, with an receiver operating characteristic area under the curve of 1.0. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Circulating miRNAs in maternal blood offer promising biomarkers for predicting CDH outcomes. miRNAs from infant blood provide mechanistic insights and potential targets for therapeutic intervention in critical pathways of pulmonary hypertension and lung hypoplasia. Further studies with larger cohorts are needed to validate these findings and explore the clinical application of miRNA biomarkers in CDH management. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">biomarker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22congenital+diaphragmatic+hernia+(CDH)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">congenital diaphragmatic hernia (CDH)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microRNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pathways%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pathways</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pulmonary+hypertension%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pulmonary hypertension</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22random+forest%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">random forest</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Dong L</b>, He Y, Yang L, He Y, Zhu F. The Novel HLA-E Allele, HLA-E*01:151, Identified in a Chinese Individual. <em class='incite-journal-name' onclick='ShowInCiteJournal(10422);'>HLA</em> 2024;<b>104</b>:e15773. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39564865' target='_blank'>39564865</a> DOI: <a href='https://dx.doi.org/10.1111/tan.15773' target='_blank'>10.1111/tan.15773</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/tan.15773','39564865', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(14);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/tan.15773' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10422);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/21/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1111/tan.15773" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">HLA-E*01:151 differs from HLA-E*01:03:01:01 by a single nucleotide substitution at position 890 C>T in exon 5. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HLA%e2%80%90E*01%3a151%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HLA‐E*01:151</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22novel+allele%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">novel allele</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alleles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alleles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exons%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exons</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Asian+People%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Asian People/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HLA-E+Antigens%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HLA-E Antigens</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Histocompatibility+Antigens+Class+I%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Histocompatibility Antigens Class I/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Histocompatibility+Antigens+Class+I%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Histocompatibility Antigens Class I/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Base+Sequence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Base Sequence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Histocompatibility+Testing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Histocompatibility Testing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sequence+Analysis%2c+DNA%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sequence Analysis, DNA/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymorphism%2c+Single+Nucleotide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymorphism, Single Nucleotide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sequence+Alignment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sequence Alignment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Codon%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Codon</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">China</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22East+Asian+People%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">East Asian People</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+Research+Foundation+of+Zhejiang+Healthy+Bureau%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2022KY733 Science Research Foundation of Zhejiang Healthy Bureau</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+Research+Foundation+of+Zhejiang+Healthy+Bureau%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2024KY940 Science Research Foundation of Zhejiang Healthy Bureau</a></li></ul> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Schacksen PS</b>, Østergaard SK, Eskildsen MH, Nielsen JL. Complete pipeline for Oxford Nanopore Technology amplicon <span class="highlight-field">sequencing</span> (ONT-AmpSeq): from pre-processing to creating an operational taxonomic unit table. <em class='incite-journal-name' onclick='ShowInCiteJournal(9121);'>FEBS Open Bio</em> 2024;<b>14</b>:1779-1787. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39109544' target='_blank'>39109544</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532972' target='_blank'>PMC11532972</a> DOI: <a href='https://dx.doi.org/10.1002/2211-5463.13868' target='_blank'>10.1002/2211-5463.13868</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1002/2211-5463.13868','39109544', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(15);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1002/2211-5463.13868' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9121);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/02/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1002/2211-5463.13868" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Amplicon sequencing has long served as a robust method for characterising microbial communities, and despite inherent resolution limitations, it remains a preferred technique, offering cost- and time-effective insights into bacterial compositions. Here, we introduce ONT-AmpSeq, a user-friendly pipeline designed for processing amplicon sequencing data generated from Oxford Nanopore Technology (ONT) devices. Our pipeline enables efficient creation of taxonomically annotated operational taxonomic unit (OTU) tables from ONT sequencing data, with the flexibility to multiplex amplicons on the same barcode. The pipeline encompasses six main steps-statistics, quality filtering, alignment, clustering, polishing, and taxonomic classification-integrating various state-of-the-art software tools. We provide a detailed description of each step, along with performance tests and robustness evaluations using both test data and a ZymoBIOMICS® Microbial Community Standard mock community dataset. Our results demonstrate the ability of ONT-AmpSeq to effectively process ONT amplicon data, offering valuable insights into microbial community composition. Additionally, we discuss the influence of polishing tools on taxonomic insight and the impact of taxonomic annotation methods on the derived microbial composition. Overall, ONT-AmpSeq represents a comprehensive solution for analysing ONT amplicon sequencing data, facilitating streamlined and reliable microbial community analysis. The pipeline, along with test data, is freely available for public use. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AmpSeq%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AmpSeq</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amplicon%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amplicon</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanopore%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanopore</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22OTU+table%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">OTU table</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pipeline%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pipeline</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Software%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Software</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanopore+Sequencing%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanopore Sequencing/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microbiota%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microbiota/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22High-Throughput+Nucleotide+Sequencing%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">High-Throughput Nucleotide Sequencing/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sequence+Analysis%2c+DNA%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sequence Analysis, DNA/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteria%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteria/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bacteria%2fclassification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bacteria/classification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nanopores%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nanopores</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Computational+Biology%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Computational Biology/methods</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Teknologi+og+Produktion%2c+Det+Frie+Forskningsr%c3%a5d%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">9041-00367B Teknologi og Produktion, Det Frie Forskningsråd</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22European+Maritime+and+Fisheries+Fund%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">33113-B-23-190 European Maritime and Fisheries Fund</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Novo+Nordisk+Fonden%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NNFSA210073688 Novo Nordisk Fonden</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Teknologi+og+Produktion%2c+Det+Frie+Forskningsr%c3%a5d%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Teknologi og Produktion, Det Frie Forskningsråd </a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22European+Maritime+and+Fisheries+Fund%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">European Maritime and Fisheries Fund </a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Novo+Nordisk+Fonden%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Novo Nordisk Fonden </a></li></ul> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Chow A</b>, Lareau CA. Concepts and new developments in droplet-based single cell multi-omics. <em class='incite-journal-name' onclick='ShowInCiteJournal(22914);'>Trends Biotechnol</em> 2024;<b>42</b>:1379-1395. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39095258' target='_blank'>39095258</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568944' target='_blank'>PMC11568944</a> DOI: <a href='https://dx.doi.org/10.1016/j.tibtech.2024.07.006' target='_blank'>10.1016/j.tibtech.2024.07.006</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.tibtech.2024.07.006','39095258', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(16);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.tibtech.2024.07.006' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(22914);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/04/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1016/j.tibtech.2024.07.006" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Single cell sequencing technologies have become a fixture in the molecular profiling of cells due to their ease, flexibility, and commercial availability. In particular, partitioning individual cells inside oil droplets via microfluidic reactions enables transcriptomic or multi-omic measurements for thousands of cells in parallel. Complementing the multitude of biological discoveries from genomics analyses, the past decade has brought new capabilities from assay baselines to enable a deeper understanding of the complex data from single cell multi-omics. Here, we highlight four innovations that have improved the reliability and understanding of droplet microfluidic assays. We emphasize new developments that further orient principles of technology development and guidelines for the design, benchmarking, and implementation of new droplet-based methodologies. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bioinformatics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bioinformatics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microfluidics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microfluidics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22multi-omics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">multi-omics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22single+cell%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">single cell</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Single-Cell+Analysis%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Single-Cell Analysis/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genomics%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genomics/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microfluidic+Analytical+Techniques%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microfluidic Analytical Techniques/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microfluidics%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microfluidics/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multiomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multiomics</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P30 CA008748 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NHGRI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R00 HG012579 NHGRI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Ren Y</b>, Ciwang R, Mehmood K, Li K. Effects of forages on the microbiota of crossed sheep on cold Plateau. <em class='incite-journal-name' onclick='ShowInCiteJournal(1887);'>Anim Biotechnol</em> 2024;<b>35</b>:2362639. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38856695' target='_blank'>38856695</a> DOI: <a href='https://dx.doi.org/10.1080/10495398.2024.2362639' target='_blank'>10.1080/10495398.2024.2362639</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/10495398.2024.2362639','38856695', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/10495398.2024.2362639' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(1887);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/11/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.1080/10495398.2024.2362639" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Diet is an important component to influence microbiota, there are less data available about the microbiome of Suffolk cross with Tibetan (SCT) animals with different fodders. The current study was conducted for comparing the fungi microbiota in SCT sheep fed with different forages. Sequencing of ileum samples from sheep groups of AH (alfalfa and oat grass), BH (mixture of grass and concentrated feeds), CH (concentrated feed I), DH (concentrated feed II) and EH (concentrated feed III) achieved 3,171,271 raw and 2,719,649 filtered sequences. Concentrated feeds changed fungi microbiota in SCT sheep with three phyla and 47 genera significantly different among the groups. Genera include positive genus of Scytalidium and negative fungi of Sarocladium, Kazachstania, Gibberella, Scytalidium, Candida, Wickerhamomyces. The findings of our study will contribute to efficient feeding of SCT sheep at cold plateau areas. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Provender%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Provender</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22flora%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">flora</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ileum%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ileum</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tibetan+sheep%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tibetan sheep</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sheep%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sheep/microbiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animal+Feed%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animal Feed</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diet%2fveterinary%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diet/veterinary</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Microbiome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Microbiome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fungi%2fclassification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fungi/classification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fungi%2fisolation+%26amp%3b+purification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fungi/isolation & purification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Microbiota%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Microbiota</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tibet%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tibet</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ileum%2fmicrobiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ileum/microbiology</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Zhang C</b>, Lu YJ, Wang M, Chen B, Xiong F, Mitsopoulos C, Rossanese O, Li X, Clarke PA. Characterisation of APOBEC3B-Mediated RNA editing in breast cancer cells reveals regulatory roles of NEAT1 and MALAT1 lncRNAs. <em class='incite-journal-name' onclick='ShowInCiteJournal(18284);'>Oncogene</em> 2024;<b>43</b>:3366-3377. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39322638' target='_blank'>39322638</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554567' target='_blank'>PMC11554567</a> DOI: <a href='https://dx.doi.org/10.1038/s41388-024-03171-5' target='_blank'>10.1038/s41388-024-03171-5</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41388-024-03171-5','39322638', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(18);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41388-024-03171-5' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18284);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/16/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/13/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/27/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1038/s41388-024-03171-5" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">RNA editing is a crucial post-transcriptional process that influences gene expression and increases the diversity of the proteome as a result of amino acid substitution. Recently, the APOBEC3 family has emerged as a significant player in this mechanism, with APOBEC3A (A3A) having prominent roles in base editing during immune and stress responses. APOBEC3B (A3B), another family member, has gained attention for its potential role in generating genomic DNA mutations in breast cancer. In this study, we coupled an inducible expression cell model with a novel methodology for identifying differential variants in RNA (DVRs) to map A3B-mediated RNA editing sites in a breast cancer cell model. Our findings indicate that A3B engages in selective RNA editing including targeting NEAT1 and MALAT1 long non-coding RNAs that are often highly expressed in tumour cells. Notably, the binding of these RNAs sequesters A3B and suppresses global A3B activity against RNA and DNA. Release of A3B from NEAT1/MALAT1 resulted in increased A3B activity at the expense of A3A activity suggesting a regulatory feedback loop between the two family members. This research substantially advances our understanding of A3B's role in RNA editing, its mechanistic underpinnings, and its potential relevance in the pathogenesis of breast cancer. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22breast+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">breast cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mechanisms+of+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mechanisms of disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22oncogenes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">oncogenes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mutation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mutation</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Breast+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Breast Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Minor+Histocompatibility+Antigens%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Minor Histocompatibility Antigens/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Minor+Histocompatibility+Antigens%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Minor Histocompatibility Antigens/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA+Editing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA Editing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytidine+Deaminase%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytidine Deaminase/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cytidine+Deaminase%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cytidine Deaminase/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Science+and+Technology+Commission+of+Shanghai+Municipality+(Shanghai+Municipal+Science+and+Technology+Commission)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">23S11901100 Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22The+Shanghai+Pujiang+Programme+is+hosted+by+Shanghai+Municipal+Government%2c+with+details+found+at%3a+https%3a%2f%2fwww.shanghai.gov.cn%2fnw49548%2f20201013%2f0001-49548_130060.html%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">The Shanghai Pujiang Programme is hosted by Shanghai Municipal Government, with details found at: https://www.shanghai.gov.cn/nw49548/20201013/0001-49548_130060.html</a></li></ul> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Turner JH</b>. Theranostics: Timing is Everything. <em class='incite-journal-name' onclick='ShowInCiteJournal(4446);'>Cancer Biother Radiopharm</em> 2024;<b>39</b>:611-618. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38757676' target='_blank'>38757676</a> DOI: <a href='https://dx.doi.org/10.1089/cbr.2024.0088' target='_blank'>10.1089/cbr.2024.0088</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1089/cbr.2024.0088','38757676', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1089/cbr.2024.0088' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4446);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/18/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1089/cbr.2024.0088" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">On stage, and in real life, timing is critical for success. Theranostic cancer care epitomizes the central role of timing in the evolution of efficacious molecular targeted radioligand therapy and its incorporation into routine clinical practice of oncology. Nuclear medicine has returned to its therapeutic roots, having been founded as a medical specialty, over three-quarters of a century ago, with radioiodine therapy of thyroid cancer. The very recent oncologist acceptance of 68Ga/177Lu/225Ac-PSMA effectiveness in treating prostate cancer has re-established the role of the physician in nuclear medicine. This article addresses various important issues in respect of timing related to this resurgence. Training of the required new workforce in technical -omics expertise and physicianly virtues is an urgent priority. Precision in radioligand therapy requires definition of individual radiation absorbed dose (Gy) to tumor and to critical normal organs, preferably prospectively. It is time to abandon one-size-fits-all administration of fixed activities (GBq) in arbitrary cycle intervals and duration. The time has also come to design combination sequenced theranostic-immuno-chemotherapeutic approaches to metastatic cancer to address unmet needs, particularly in pancreatic carcinoma; exploiting the potential of new fibroblast activation protein inhibitor radioligands targeting the tumor microenvironment. Public perception of all things "nuclear," including nuclear medicine, has recently recovered from the general opprobrium and radiophobia of the last half-century. Nuclear is the new green. At last, there have arisen propitious circumstances for the future development of theranostics: The timing is right, now. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22dosimetry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">dosimetry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22phronesis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">phronesis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22radioligand+FAPI+pancreas+cancer+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">radioligand FAPI pancreas cancer therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22theranostic+nuclear+medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">theranostic nuclear medicine</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2ftherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fradiotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/radiotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nuclear+Medicine%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nuclear Medicine/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Precision+Medicine%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Precision Medicine/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Radiopharmaceuticals%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Radiopharmaceuticals/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Theranostic+Nanomedicine%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Theranostic Nanomedicine/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Time+Factors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Time Factors</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Walden KKO</b>, Cao Y, Fields CJ, Hernandez AG, Rendon GA, Robinson GE, Skinner RK, Stein JA, Dietrich CH. High-quality genome assemblies for nine non-model North American insect species representing six orders (Insecta: Coleoptera, Diptera, Hemiptera, Hymenoptera, Lepidoptera, Neuroptera). <em class='incite-journal-name' onclick='ShowInCiteJournal(17410);'>Mol Ecol Resour</em> 2024;<b>24</b>:e14010. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39155537' target='_blank'>39155537</a> DOI: <a href='https://dx.doi.org/10.1111/1755-0998.14010' target='_blank'>10.1111/1755-0998.14010</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/1755-0998.14010','39155537', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(20);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/1755-0998.14010' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17410);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/11/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/20/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1111/1755-0998.14010" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Field-collected specimens were used to obtain nine high-quality genome assemblies from a total of 10 insect species native to prairies and savannas of central Illinois (USA): Mellilla xanthometata (Lepidoptera: Geometridae), Stenolophus ochropezus (Coleoptera: Carabidae), Forcipata loca (Hemiptera: Cicadellidae), Coelinius sp. (Hymenoptera: Braconidae), Thaumatomyia glabra (Diptera: Chloropidae), Brachynemurus abdominalus (Neuroptera: Myrmeleontidae), Catonia carolina (Hemiptera: Achilidae), Oncometopia orbona (Hemiptera: Cicadellidae), Flexamia atlantica (Hemiptera: Cicadellidae) and Stictocephala bisonia (Hemiptera: Membracidae). Sequencing library preparation from single specimens was successful despite extremely small DNA yields (<0.1 μg) for some samples. Additional sequencing and assembly workflows were adapted to each sample depending on the initial DNA yield. PacBio circular consensus (CCS/HiFi) or continuous long reads (CLR) libraries were used to sequence DNA fragments up to 50 kb in length, with Illumina sequenced linked-reads (TellSeq libraries) and Omni-C libraries used for scaffolding and gap-filling. Assembled genome sizes ranged from 135 MB to 3.2 GB. The number of assembled scaffolds ranged from 47 to >13,000, with the longest scaffold per assembly ranging from ~23 to 439 Mb. Genome completeness was high, with BUSCO scores ranging from 85.5% completeness for the largest genome (Stictocephala bisonia) to 98.8% completeness for the smallest genome (Coelinius sp.). The unique content was estimated using RepeatMasker and GenomeScope2, which ranged from 50.7% to 75.8% and roughly decreased with increasing genome size. Structural annotation predicted a range of 19,281-72,469 protein models for sequenced species. Sequencing costs per genome at the time ranged from US$3-5k, averaged ~1600 CPU-hours on a high-performance cluster and required approximately 14 h of bioinformatics analyses with samples using PacBio HiFi data. Most assemblies would benefit from further manual curation to correct possible scaffold misjoins and translocations suggested by off-diagonal or depleted signals in Omni-C contact maps. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Earth+BioGenome+project%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Earth BioGenome project</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Insecta%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Insecta</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22annotation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">annotation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genome+assembly%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genome assembly</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22non%e2%80%90model+species%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">non‐model species</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Genome%2c+Insect%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Genome, Insect/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sequence+Analysis%2c+DNA%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sequence Analysis, DNA/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Insecta%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Insecta/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Insecta%2fclassification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Insecta/classification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Illinois%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Illinois</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Directorate+for+Biological+Sciences%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DEB 1639601 Directorate for Biological Sciences</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Illinois+Innovation+Network%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Illinois Innovation Network</a></li></ul> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Usuga J</b>, Limonta D, Perez-Restrepo LS, Ciuoderis KA, Moreno I, Arevalo A, Vargas V, Berg MG, Cloherty GA, Hernandez-Ortiz JP, Osorio JE. Co-Circulation of 2 Oropouche Virus Lineages, Amazon Basin, Colombia, 2024. <em class='incite-journal-name' onclick='ShowInCiteJournal(8179);'>Emerg Infect Dis</em> 2024;<b>30</b>:2375-2380. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39356574' target='_blank'>39356574</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521167' target='_blank'>PMC11521167</a> DOI: <a href='https://dx.doi.org/10.3201/eid3011.240405' target='_blank'>10.3201/eid3011.240405</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3201/eid3011.240405','39356574', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3201/eid3011.240405' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8179);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/04/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.3201/eid3011.240405" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">In early 2024, explosive outbreaks of Oropouche virus (OROV) linked to a novel lineage were documented in the Amazon Region of Brazil. We report the introduction of this lineage into Colombia and its co-circulation with another OROV lineage. Continued surveillance is needed to prevent further spread of OROV in the Americas. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amazon+Basin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amazon Basin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colombia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colombia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leticia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leticia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oropouche+virus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oropouche virus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22fever%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">fever</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lineages%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lineages</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22outbreak%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">outbreak</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22reassortant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">reassortant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22reassortment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">reassortment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22vector-borne+infections%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">vector-borne infections</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22viruses%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">viruses</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22zoonoses%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">zoonoses</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colombia%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colombia/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Orthobunyavirus%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Orthobunyavirus/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Orthobunyavirus%2fclassification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Orthobunyavirus/classification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phylogeny%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phylogeny</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bunyaviridae+Infections%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bunyaviridae Infections/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bunyaviridae+Infections%2fvirology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bunyaviridae Infections/virology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Outbreaks%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Outbreaks</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brazil%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brazil/epidemiology</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Grubaugh ND</b>, Torres-Hernández D, Murillo-Ortiz MA, Dávalos DM, Lopez P, Hurtado IC, Breban MI, Bourgikos E, Hill V, López-Medina E. Dengue Outbreak Caused by Multiple Virus Serotypes and Lineages, Colombia, 2023-2024. <em class='incite-journal-name' onclick='ShowInCiteJournal(8179);'>Emerg Infect Dis</em> 2024;<b>30</b>:2391-2395. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39378873' target='_blank'>39378873</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521178' target='_blank'>PMC11521178</a> DOI: <a href='https://dx.doi.org/10.3201/eid3011.241031' target='_blank'>10.3201/eid3011.241031</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3201/eid3011.241031','39378873', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(22);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3201/eid3011.241031' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8179);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/10/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.3201/eid3011.241031" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Dengue cases rose to record levels during 2023-2024. We investigated dengue in Valle del Cauca, Colombia, to determine if specific virus serotypes or lineages caused its large outbreak. We detected all 4 serotypes and multiple lineages, suggesting that factors such as climatic conditions were likely responsible for increased dengue in Colombia. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colombia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colombia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dengue%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dengue</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lineages%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lineages</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mosquitoborne+diseases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mosquitoborne diseases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22outbreak%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">outbreak</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22phylogenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">phylogenetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22serotypes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">serotypes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22vector-borne+infections%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">vector-borne infections</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22viruses%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">viruses</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colombia%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colombia/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Outbreaks%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Outbreaks</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dengue%2fepidemiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dengue/epidemiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dengue%2fvirology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dengue/virology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dengue+Virus%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dengue Virus/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dengue+Virus%2fclassification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dengue Virus/classification</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Serogroup%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Serogroup</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phylogeny%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phylogeny</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22History%2c+21st+Century%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">History, 21st Century</a></li></ul> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAID+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DP2 AI176740 NIAID NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">S10 OD028669 NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width: 40px; text-align: center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Naumov DE</b>, Kotova OO, Gassan DA, Sugaylo IY, Sheludko EG, Gorchakova YG. Transriptome Analysis of Peripheral Blood Monocytes in Chronic Obstructive Pulmonary Disease Patients. <em class='incite-journal-name' onclick='ShowInCiteJournal(8079);'>DOKL BIOCHEM BIOPHYS</em> 2024:10.1134/S1607672924701199. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39480635' target='_blank'>39480635</a> DOI: <a href='https://dx.doi.org/10.1134/s1607672924701199' target='_blank'>10.1134/s1607672924701199</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1134/s1607672924701199','39480635', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1134/s1607672924701199' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8079);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/02/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1134/s1607672924701199" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">It is known that monocytes can make a significant contribution to the development of chronic obstructive pulmonary disease (COPD); however, the features of the transcriptome of these cells associated with the disease remain poorly understood. </div><div class="abstract-label">AIM</div><div class="abstract-content">: The aim of the study was to perform monocyte transcriptome analysis for identification of differentially expressed genes and key disturbances in biological processes in these cells in COPD. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">. The study included three COPD patients and three smokers without bronchial obstruction. Monocytes were obtained from peripheral blood mononuclear cells using the plastic adhesion method. The cell purity achieved as a result of enrichment was approximately 90% according to flow cytometry data. The isolated RNA samples were purified from genomic DNA and ribosomal RNA. The samples were sequenced on a MGISEQ-200 sequencer in SE50 mode. Read mapping and transcript counting were performed in Salmon v1.10.1 software; further data processing was carried out in R software environment. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">: As a result of the analysis, 21 upregulated and 29 downregulated genes were found in monocytes from COPD patients. Among the genes with increased expression, the most significant were the noncoding RNAs PKD1P5-LOC105376752 and PKD1P4-NPIPA8, the role of which remains unclear, as well as SETDB2, RNASE6, SERPINE1, and MRC1. Downregulated genes, of which F8A2, ZDHHC19, CXCL9, CXCL10, HBA1, HBB, C2, CFB, CFD, MT1B, MT1G, and TIMP3 were of most interest, showed enrichment in seven gene ontology (GO) terms, including those related to response to lipopolysaccharides, hydrogen peroxide, copper ions, and complement activation. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">. The data obtained indicate inhibition of monocyte functional activity in COPD patients with a decrease in the ability to provide effective protection against microbial pathogens while weakening self-protection against reactive oxygen species. Upregulation of SERPINE1 and downregulation of TIMP3 may significantly contribute to airway remodeling and emphysema development in COPD. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22COPD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">COPD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NGS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NGS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22differential+gene+expression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">differential gene expression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22monocytes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">monocytes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22smoking%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">smoking</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Sleiman K</b>, Allam S, Akiki D, Megarbane A, Bleik J. Neurofibromatosis type-2-related schwannomatosis presenting as peripapillary hamartoma: report on a novel <i>NF2</i> mutation. <em class='incite-journal-name' onclick='ShowInCiteJournal(18330);'>Ophthalmic Genet</em> 2024:1-4. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39468426' target='_blank'>39468426</a> DOI: <a href='https://dx.doi.org/10.1080/13816810.2024.2422087' target='_blank'>10.1080/13816810.2024.2422087</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/13816810.2024.2422087','39468426', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(24);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/13816810.2024.2422087' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18330);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/30/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1080/13816810.2024.2422087" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Neurofibromatosis type-2-related schwannomatosis (NF2-SWN, formerly neurofibromatosis type 2) is a rare genetic disorder marked by the development of multiple nervous system tumors. </div><div class="abstract-label">CASE PRESENTATION</div><div class="abstract-content">We report a 21-month-old female patient who presented for left eye deviation. Upon examination, intermittent exotropia and a fundus mass were detected. Wide field fundus examination revealed the presence of a combined hamartoma involving the optic nerve and retina. This finding was supported by MRI highlighting the lesion's characteristics. The patient's father and other relatives on the paternal side displayed symptoms of NF2-SWN, evident through the presence of acoustic neuroma, although they did not exhibit any ocular symptoms. DNA analysis revealed a novel loss-of-function mutation in exon 15 of the NF2 gene (NM_000268.3: c.1627_1628del, p.Lys543Aspfs *21) in both the patient and her father at a heterozygous state. By the age of three, her vision worsened, and optical coherence tomography showed vitreomacular traction and intraretinal fluid surrounding the lesion. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">This case underscores the need to consider NF2- SWN in peripapillary hamartoma diagnoses and highlights the importance of genetic testing for early detection and management. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lebanon%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lebanon</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hamartoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hamartoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22neurofibromatosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">neurofibromatosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22retina%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">retina</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Pearman WS</b>, Arranz V, Carvajal JI, Whibley A, Liau Y, Johnson K, Gray R, Treece JM, Gemmell NJ, Liggins L, Fraser CI, Jensen EL, Green NJ. A cry for kelp: Evidence for polyphenolic inhibition of Oxford Nanopore <span class="highlight-field">sequencing</span> of brown algae. <em>JOURNAL OF PHYCOLOGY</em> 2024. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39435595' target='_blank'>39435595</a> DOI: <a href='https://dx.doi.org/10.1111/jpy.13513' target='_blank'>10.1111/jpy.13513</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/jpy.13513','39435595', 'sequencing')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/jpy.13513' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/23/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1111/jpy.13513" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Genomic resources have yielded unprecedented insights into ecological and evolutionary processes, not to mention their importance in economic and conservation management of specific organisms. However, the field of macroalgal genomics is hampered by difficulties in the isolation of suitable DNA. Even when DNA that appears high quality by standard metrics has been isolated, such samples may not perform well during the sequencing process. We here have compared Oxford Nanopore long-read sequencing results for three species of macroalgae to those of nonmacroalgal species and determined that when using macroalgal samples, sequencing activity declined rapidly, resulting in reduced sequencing yield. Chemical analysis of macroalgal DNA that would be considered suitable for sequencing revealed that DNA derived from dried macroalgae was enriched for polyphenol-DNA adducts (DNA with large polyphenols chemically attached to it), which may have led to sequencing inhibition. Of note, we observed the strongest evidence of sequencing inhibition and reduced sequence output when using samples dried using silica gel-suggesting that such storage approaches may not be appropriate for samples destined for Oxford Nanopore sequencing. Our findings have wide-ranging implications for the generation of genomic resources from macroalgae and suggest a need to develop new storage methods that are more amenable to Oxford Nanopore sequencing or to use fresh flash-frozen tissue wherever possible for genome sequencing. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA+extraction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA extraction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22genome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">genome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22macroalgae%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">macroalgae</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nanopore%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nanopore</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22polyphenols%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">polyphenols</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">sequencing</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(25);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> </tbody></table> <div class="search-pager-container"> <div class="dxpLite_MetropolisBlue" id="RootHolder_SearchResultPager" style="margin-top: 20px; margin-bottom: 20px;"> <b class="dxp-lead dxp-button dxp-bi dxp-disabledButton"><img class="dxWeb_pPrevDisabled_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Prev" /></b><b class="dxp-summary" style="margin-left:0px;">Page 1 of 93 </b><b class="dxp-num dxp-current page-number" style="margin-left:0px;">1</b><a class="dxp-num page-number" href="/Search?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">2</a><a class="dxp-num page-number" href="/Search?page=3&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">3</a><a class="dxp-num page-number" href="/Search?page=4&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">4</a><a class="dxp-num page-number" href="/Search?page=5&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">5</a><b class="dxp-ellip" style="margin-left:0px;">…</b><a class="dxp-num page-number" href="/Search?page=92&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">92</a><a class="dxp-num page-number" href="/Search?page=93&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">93</a><a class="dxp-button dxp-bi" onclick="ASPx.PGNav(event);" href="/Search?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;"><img class="dxWeb_pNext_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Next" /></a> </div><b class="dx-clear"></b><script id="dxss_1145490977" type="text/javascript">  </script> </div> </div> <div class="cl"></div> </div> </div> </div> <table class="dxlpLoadingPanel_MetropolisBlue dxlpControl_MetropolisBlue" id="RootHolder_LeftLoadingPanel" style="position:absolute;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="text-align:Center;vertical-align:Top;"><span id="RootHolder_LeftLoadingPanel_TL">Loading…</span></td> </tr> </table><div id="RootHolder_LeftLoadingPanel_LD" class="dxlpLoadingDiv_MetropolisBlue dxlpControl_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1950550554" type="text/javascript">  </script> <div id="RootHolder_articleCitationPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:450px;width:600px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content">    </div> </div> </div> </div><div id="RootHolder_articleCitationPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleCitationPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleCitationPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleCitationPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1115091042" type="text/javascript">  </script> <div id="RootHolder_chartPopupControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:1000px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_chartPopupControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_pcImportArticlesControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:50px;width:50px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcImportArticlesControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Import Articles</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="RootHolder_pcImportArticlesControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcImportArticlesControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcImportArticlesControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcImportArticlesControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_365297802" type="text/javascript">  </script> <div id="RootHolder_pcEditArticleControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_pcEditArticleControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Edit My Journal Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_pcEditArticleControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_pcEditArticleControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1286575841" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:280px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">sequencing (2316 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">sequencing (2316 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="600" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_424125632" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_2124675053" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_578446409" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>