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Pruthi</title> <meta name="description" content="Search results for: Nupur Pruthi"> <meta name="keywords" content="Nupur Pruthi"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Nupur Pruthi"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 7</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Nupur Pruthi</h1> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> The Relationship of the Dentate Nucleus with the Pyramid of Vermis: A Microneurosurgical Anatomical Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Santhosh%20K.%20S.%20Annayappa">Santhosh K. S. Annayappa</a>, <a href="https://publications.waset.org/search?q=Nupur%20Pruthi"> Nupur Pruthi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The region of dentate nucleus is a common site for various pathologies like hematomas, tumours, etc. We aimed to study in detail the relationship of this region with the vermis, especially the pyramid using microscopic fibre dissection technique. To achieve this aim, 20 cerebellar hemispheres were studied from the 11 cerebellums. Dissection was performed using wooden spatulas and micro dissectors under a microscope following Klingler’s preservation technique. The relationship between the pyramid of vermis and the dentate nucleus was studied in detail. A similar relationship was studied on the MRI of randomly selected trigeminal neuralgia patients and correlated with anatomical findings. Results show the mean distance of the lateral margin of the dentate nucleus from the midline on anatomic specimens was 21.4 ± 1.8 mm (19-25 mm) and 23.4 ± 3.4 mm (15-29 mm) on right and left side, respectively. Similar measurements made on the MRI were 22.97 ± 2.0 mm (20.03-26.15 mm) on the right side and 23.98 ± 2.1 mm (21.47-27.67 mm) on the left side. The amount of white matter dissection required to reach the dentate nucleus at the pyramidal attachment area was 7.3 ± 1.0 mm (6-9 mm) on the right side and 6.8 ± 1.4 mm (5-10 mm) on the left side. It was concluded that the pyramid of vermis has a constant relationship with the dentate nucleus and can be used as an excellent landmark during surgery to localise the dentate nucleus on the suboccipital surface. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Fiber%20dissection" title="Fiber dissection">Fiber dissection</a>, <a href="https://publications.waset.org/search?q=micro%20neurosurgery" title=" micro neurosurgery"> micro neurosurgery</a>, <a href="https://publications.waset.org/search?q=dentate%20nucleus%20of%20cerebellum" title=" dentate nucleus of cerebellum"> dentate nucleus of cerebellum</a>, <a href="https://publications.waset.org/search?q=pyramid%20of%20vermis." title=" pyramid of vermis."> pyramid of vermis.</a> </p> <a href="https://publications.waset.org/10009977/the-relationship-of-the-dentate-nucleus-with-the-pyramid-of-vermis-a-microneurosurgical-anatomical-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10009977/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10009977/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10009977/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10009977/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10009977/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10009977/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10009977/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10009977/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10009977/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10009977/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10009977.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1240</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> A Low Voltage High Performance Self Cascode Current Mirror</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Jasdeep%20Kaur">Jasdeep Kaur</a>, <a href="https://publications.waset.org/search?q=Nupur%20Prakash"> Nupur Prakash</a>, <a href="https://publications.waset.org/search?q=S.%20S.%20Rajput"> S. S. Rajput</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A current mirror (CM) based on self cascode MOSFETs low voltage analog and mixed mode structures has been proposed. The proposed CM has high output impedance and can operate at 0.5 V. P-Spice simulations confirm the high performance of this CM with a bandwidth of 6.0 GHz at input current of 100 渭A. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Current%20Mirrors" title="Current Mirrors">Current Mirrors</a>, <a href="https://publications.waset.org/search?q=Composite%20Cascode%20Structure" title=" Composite Cascode Structure"> Composite Cascode Structure</a>, <a href="https://publications.waset.org/search?q=Current%20Source%2FSink" title=" Current Source/Sink"> Current Source/Sink</a> </p> <a href="https://publications.waset.org/249/a-low-voltage-high-performance-self-cascode-current-mirror" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/249/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/249/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/249/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/249/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/249/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/249/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/249/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/249/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/249/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/249/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/249.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">4381</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> A Study of Agile-Based Approaches to Improve Software Quality</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Gurmeet%20Kaur">Gurmeet Kaur</a>, <a href="https://publications.waset.org/search?q=Jyoti%20Pruthi"> Jyoti Pruthi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Agile Software development approaches and techniques are being considered as efficient, effective, and popular methods to the development of software. Agile software developments are useful for developing high-quality software that completes client requirements with zero defects, and in short delivery period. In agile software development methodology, quality is related to coding, which means quality, is managed through the use of approaches like refactoring, pair programming, test-driven development, behavior-driven development, acceptance test-driven development, and demand-driven development. The quality of software is measured using metrics like the number of defects during the development and improvement of the software. Usage of the above-mentioned methods or approaches reduces the possibilities of defects in developed software, and hence improves quality. This paper focuses on the study of agile-based quality methods or approaches for software development that ensures improved quality of software as well as reduced cost, and customer satisfaction.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Agile%20software%20development" title="Agile software development">Agile software development</a>, <a href="https://publications.waset.org/search?q=ASD" title=" ASD"> ASD</a>, <a href="https://publications.waset.org/search?q=Acceptance%20test-driven%20development" title=" Acceptance test-driven development"> Acceptance test-driven development</a>, <a href="https://publications.waset.org/search?q=ATDD" title=" ATDD"> ATDD</a>, <a href="https://publications.waset.org/search?q=Behavior-driven%20development" title=" Behavior-driven development"> Behavior-driven development</a>, <a href="https://publications.waset.org/search?q=BDD" title=" BDD"> BDD</a>, <a href="https://publications.waset.org/search?q=Demand-driven%20development.%20DDD" title=" Demand-driven development. DDD"> Demand-driven development. DDD</a>, <a href="https://publications.waset.org/search?q=Test-driven%20development" title=" Test-driven development"> Test-driven development</a>, <a href="https://publications.waset.org/search?q=TDD." title=" TDD."> TDD.</a> </p> <a href="https://publications.waset.org/10012548/a-study-of-agile-based-approaches-to-improve-software-quality" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10012548/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10012548/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10012548/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10012548/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10012548/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10012548/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10012548/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10012548/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10012548/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10012548/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10012548.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">691</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> A Socio-Ecological Study of Sacred Groves and Memorial Parks: Cases from USA and India</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Ishani%20Pruthi">Ishani Pruthi</a>, <a href="https://publications.waset.org/search?q=William%20Burch%20Jr"> William Burch Jr</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The concept of sacred and nature have long been interlinked. Various cultural aspects such as religion, faith, traditions bring people closer to nature and the natural environment. Memorial Parks and Sacred Groves are examples of two such cultural landscapes that exist today. The project mainly deals with the significance of such sites to the environment and the deep rooted significance it has to the people. These parks and groves play an important role in biodiversity conservation and environmental protection. There are many differences between the establishment of memorial parks and sacred groves, but the underlying significance is the same. Sentiments, emotions play an important role in landscape planning and management. Hence the people and communities living at these sites need to be involved in any planning activity or decisions. The conservation of the environment should appeal to the sentiments of the people; the need to be 'with nature' should be used in the setting up of memorial forests and in the preservation of sacred groves. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Sacred%20groves" title="Sacred groves">Sacred groves</a>, <a href="https://publications.waset.org/search?q=memorial%20forests" title=" memorial forests"> memorial forests</a>, <a href="https://publications.waset.org/search?q=community%0Abased%20natural%20resource%20management." title=" community based natural resource management."> community based natural resource management.</a> </p> <a href="https://publications.waset.org/15216/a-socio-ecological-study-of-sacred-groves-and-memorial-parks-cases-from-usa-and-india" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/15216/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/15216/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/15216/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/15216/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/15216/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/15216/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/15216/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/15216/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/15216/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/15216/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/15216.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2422</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Detecting Subsurface Circular Objects from Low Contrast Noisy Images: Applications in Microscope Image Enhancement</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Soham%20De">Soham De</a>, <a href="https://publications.waset.org/search?q=Nupur%20Biswas"> Nupur Biswas</a>, <a href="https://publications.waset.org/search?q=Abhijit%20Sanyal"> Abhijit Sanyal</a>, <a href="https://publications.waset.org/search?q=Pulak%20Ray"> Pulak Ray</a>, <a href="https://publications.waset.org/search?q=Alokmay%20Datta"> Alokmay Datta</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Particle detection in very noisy and low contrast images is an active field of research in image processing. In this article, a method is proposed for the efficient detection and sizing of subsurface spherical particles, which is used for the processing of softly fused Au nanoparticles. Transmission Electron Microscopy is used for imaging the nanoparticles, and the proposed algorithm has been tested with the two-dimensional projected TEM images obtained. Results are compared with the data obtained by transmission optical spectroscopy, as well as with conventional circular object detection algorithms. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Transmission%20Electron%20Microscopy" title="Transmission Electron Microscopy">Transmission Electron Microscopy</a>, <a href="https://publications.waset.org/search?q=Circular%20Hough%0ATransform" title=" Circular Hough Transform"> Circular Hough Transform</a>, <a href="https://publications.waset.org/search?q=Au%20Nanoparticles" title=" Au Nanoparticles"> Au Nanoparticles</a>, <a href="https://publications.waset.org/search?q=Median%20Filter" title=" Median Filter"> Median Filter</a>, <a href="https://publications.waset.org/search?q=Laplacian%20Sharpening%0AFilter" title=" Laplacian Sharpening Filter"> Laplacian Sharpening Filter</a>, <a href="https://publications.waset.org/search?q=Canny%20Edge%20Detection" title=" Canny Edge Detection"> Canny Edge Detection</a> </p> <a href="https://publications.waset.org/956/detecting-subsurface-circular-objects-from-low-contrast-noisy-images-applications-in-microscope-image-enhancement" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/956/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/956/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/956/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/956/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/956/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/956/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/956/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/956/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/956/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/956/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/956.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2583</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Comparison of Deep Convolutional Neural Networks Models for Plant Disease Identification</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Megha%20Gupta">Megha Gupta</a>, <a href="https://publications.waset.org/search?q=Nupur%20Prakash"> Nupur Prakash</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Identification of plant diseases has been performed using machine learning and deep learning models on the datasets containing images of healthy and diseased plant leaves. The current study carries out an evaluation of some of the deep learning models based on convolutional neural network architectures for identification of plant diseases. For this purpose, the publicly available New Plant Diseases Dataset, an augmented version of PlantVillage dataset, available on Kaggle platform, containing 87,900 images has been used. The dataset contained images of 26 diseases of 14 different plants and images of 12 healthy plants. The CNN models selected for the study presented in this paper are AlexNet, ZFNet, VGGNet (four models), GoogLeNet, and ResNet (three models). The selected models are trained using PyTorch, an open-source machine learning library, on Google Colaboratory. A comparative study has been carried out to analyze the high degree of accuracy achieved using these models. The highest test accuracy and F1-score of 99.59% and 0.996, respectively, were achieved by using GoogLeNet with Mini-batch momentum based gradient descent learning algorithm.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=comparative%20analysis" title="comparative analysis">comparative analysis</a>, <a href="https://publications.waset.org/search?q=convolutional%20neural%20networks" title=" convolutional neural networks"> convolutional neural networks</a>, <a href="https://publications.waset.org/search?q=deep%20learning" title=" deep learning"> deep learning</a>, <a href="https://publications.waset.org/search?q=plant%20disease%20identification" title=" plant disease identification"> plant disease identification</a> </p> <a href="https://publications.waset.org/10012290/comparison-of-deep-convolutional-neural-networks-models-for-plant-disease-identification" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10012290/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10012290/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10012290/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10012290/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10012290/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10012290/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10012290/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10012290/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10012290/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10012290/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10012290.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">638</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Outcomes of Pregnancy in Women with TPO Positive Status after Appropriate Dose Adjustments of Thyroxin: A Prospective Cohort Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Revathi%20S.%20Rajan">Revathi S. Rajan</a>, <a href="https://publications.waset.org/search?q=Pratibha%20Malik"> Pratibha Malik</a>, <a href="https://publications.waset.org/search?q=Nupur%20Garg"> Nupur Garg</a>, <a href="https://publications.waset.org/search?q=Smitha%20Avula"> Smitha Avula</a>, <a href="https://publications.waset.org/search?q=Kamini%20A.%20Rao"> Kamini A. Rao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>This study aimed to analyse the pregnancy outcomes in patients with TPO positivity after appropriate L-Thyroxin supplementation with close surveillance. All pregnant women attending the antenatal clinic at Milann-The Fertility Center, Bangalore, India- from Aug 2013 to Oct 2014 whose booking TSH was more than 2.5 mIU/L were included along with those pregnant women with prior hypothyroidism who were TPO positive. Those with TPO positive status were vigorously managed with appropriate thyroxin supplementation and the doses were readjusted every 3 to 4 weeks until delivery. Women with recurrent pregnancy loss were also tested for TPO positivity and if tested positive, were monitored serially with TSH and fT4 levels every 3 to 4 weeks and appropriately supplemented with thyroxin when the levels fluctuated. The testing was done after an informed consent in all these women. The statistical software namely SAS 9.2, SPSS 15.0, Stata 10.1, MedCalc 9.0.1, Systat 12.0 and R environment ver.2.11.1 were used for the analysis of the data. 460 pregnant women were screened for thyroid dysfunction at booking of which 52% were hypothyroid. Majority of them (31.08%) were subclinically hypothyroid and the remaining were overt. 25% of the total no. of patients screened were TPO positive. The various pregnancy complications that were observed in the TPO positive women were gestational glucose intolerance [60%], threatened abortion [21%], midtrimester abortion [4.3%], premature rupture of membranes [4.3%], cervical funneling [4.3%] and fetal growth restriction [3.5%]. 95.6% of the patients who followed up till the end delivered beyond 30 weeks. 42.6% of these patients had previous history of recurrent abortions or adverse obstetric outcome and 21.7% of the delivered babies required NICU admission. Obstetric outcomes in our study in terms of midtrimester abortions, placental abruption, and preterm delivery improved for the better after close monitoring of the thyroid hormone [TSH and fT4] levels every 3 to 4 weeks with appropriate dose adjustment throughout pregnancy. Euthyroid women with TPO positive status enrolled in the study incidentally were those with recurrent abortions/infertility and required thyroxin supplements due to elevated Thyroid hormone (TSH, fT4) levels during the course of their pregnancy. Significant associations were found with age>30 years and Hyperhomocysteinemia [p=0.017], recurrent pregnancy loss or previous adverse obstetric outcomes [p=0.067] and APLA [p=0.029]. TPO antibody levels >600 I U/ml were significantly associated with development of gestational hypertension [p=0.041] and fetal growth restriction [p=0.082]. Euthyroid women with TPO positivity were also screened periodically to counter fluctuations of the thyroid hormone levels with appropriate thyroxin supplementation. Thus, early identification along with aggressive management of thyroid dysfunction and stratification of these patients based on their TPO status with appropriate thyroxin supplementation beginning in the first trimester will aid risk modulation and also help avert complications.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Antinuclear%20antibody" title="Antinuclear antibody">Antinuclear antibody</a>, <a href="https://publications.waset.org/search?q=Subclinical%20hypothyroidism" title=" Subclinical hypothyroidism"> Subclinical hypothyroidism</a>, <a href="https://publications.waset.org/search?q=Thyroxin" title=" Thyroxin"> Thyroxin</a>, <a href="https://publications.waset.org/search?q=TPO%20antibody." title=" TPO antibody."> TPO antibody.</a> </p> <a href="https://publications.waset.org/10003856/outcomes-of-pregnancy-in-women-with-tpo-positive-status-after-appropriate-dose-adjustments-of-thyroxin-a-prospective-cohort-study" 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