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dysfunction.</title> <meta name="description" content="Search results for: dysfunction."> <meta name="keywords" content="dysfunction."> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="dysfunction."> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 36</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: dysfunction.</h1> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">36</span> Comparison of Different Neural Network Approaches for the Prediction of Kidney Dysfunction</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Ali%20Hussian%20Ali%20AlTimemy">Ali Hussian Ali AlTimemy</a>, <a href="https://publications.waset.org/search?q=Fawzi%20M.%20Al%20Naima"> Fawzi M. Al Naima</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper presents the prediction of kidney dysfunction using different neural network (NN) approaches. Self organization Maps (SOM), Probabilistic Neural Network (PNN) and Multi Layer Perceptron Neural Network (MLPNN) trained with Back Propagation Algorithm (BPA) are used in this study. Six hundred and sixty three sets of analytical laboratory tests have been collected from one of the private clinical laboratories in Baghdad. For each subject, Serum urea and Serum creatinin levels have been analyzed and tested by using clinical laboratory measurements. The collected urea and cretinine levels are then used as inputs to the three NN models in which the training process is done by different neural approaches. SOM which is a class of unsupervised network whereas PNN and BPNN are considered as class of supervised networks. These networks are used as a classifier to predict whether kidney is normal or it will have a dysfunction. The accuracy of prediction, sensitivity and specificity were found for each type of the proposed networks .We conclude that PNN gives faster and more accurate prediction of kidney dysfunction and it works as promising tool for predicting of routine kidney dysfunction from the clinical laboratory data. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Kidney%20Dysfunction" title="Kidney Dysfunction">Kidney Dysfunction</a>, <a href="https://publications.waset.org/search?q=Prediction" title=" Prediction"> Prediction</a>, <a href="https://publications.waset.org/search?q=SOM" title=" SOM"> SOM</a>, <a href="https://publications.waset.org/search?q=PNN" title=" PNN"> PNN</a>, <a href="https://publications.waset.org/search?q=BPNN" title="BPNN">BPNN</a>, <a href="https://publications.waset.org/search?q=Urea%20and%20Creatinine%20levels." title=" Urea and Creatinine levels."> Urea and Creatinine levels.</a> </p> <a href="https://publications.waset.org/12166/comparison-of-different-neural-network-approaches-for-the-prediction-of-kidney-dysfunction" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/12166/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/12166/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/12166/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/12166/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/12166/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/12166/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/12166/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/12166/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/12166/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/12166/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/12166.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1932</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">35</span> Human Immunodeficiency Virus Infection and Cardiac Autonomic Neuropathy </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Sharan%20Badiger">Sharan Badiger</a>, <a href="https://publications.waset.org/search?q=Prema%20T.%20Akkasaligar"> Prema T. Akkasaligar</a>, <a href="https://publications.waset.org/search?q=Deepak%20Kadeli"> Deepak Kadeli</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Human Immunodeficiency Virus is known to affect almost all organ systems in the body. In addition to central nervous system it also affects the autonomic nervous system. Autonomic nervous dysfunction has been known to severely affect the quality of life in human immunodeficiency virus positive patients. It is known to have caused fatal consequences in late stages of the disease in patients who go in for invasive diagnostic or therapeutic procedures. The aim of this review is to determine the incidence, clinical significance and frequency of cardiac autonomic neuropathy in patients human immunodeficiency virus infection. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Autonomic%20nervous%20system" title="Autonomic nervous system">Autonomic nervous system</a>, <a href="https://publications.waset.org/search?q=autonomic%20nervous%20dysfunction" title=" autonomic nervous dysfunction"> autonomic nervous dysfunction</a>, <a href="https://publications.waset.org/search?q=cardiac%20autonomic%20dysfunction" title=" cardiac autonomic dysfunction"> cardiac autonomic dysfunction</a>, <a href="https://publications.waset.org/search?q=human%20immunodeficiency%20virus." title=" human immunodeficiency virus."> human immunodeficiency virus.</a> </p> <a href="https://publications.waset.org/10007141/human-immunodeficiency-virus-infection-and-cardiac-autonomic-neuropathy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10007141/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10007141/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10007141/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10007141/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10007141/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10007141/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10007141/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10007141/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10007141/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10007141/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10007141.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1081</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">34</span> An Acerbate Psychotics Symptoms, Social Support, Stressful Life Events, Medication Use Self-Efficacy Impact on Social Dysfunction: A Cross Sectional Self-Rated Study of Persons with Schizophrenia Patient and Misusing Methamphetamines</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Ek-Uma%20Imkome">Ek-Uma Imkome</a>, <a href="https://publications.waset.org/search?q=Jintana%20Yunibhand"> Jintana Yunibhand</a>, <a href="https://publications.waset.org/search?q=Waraporn%20Chaiyawat"> Waraporn Chaiyawat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Background: Persons with schizophrenia patient and misusing methamphetamines suffering from social dysfunction that impact on their quality of life. Knowledge of factors related to social dysfunction will guide the effective intervention. Objectives: To determine the direct effect, indirect effect and total effect of an acerbate Psychotics’ Symptoms, Social Support, Stressful life events, Medication use self-efficacy impact on social dysfunction in Thai schizophrenic patient and methamphetamine misuse. Methods: Data were collected from schizophrenic and methamphetamine misuse patient by self report. A linear structural relationship was used to test the hypothesized path model. Results: The hypothesized model was found to fit the empirical data and explained 54% of the variance of the psychotic symptoms (X<sup>2</sup> = 114.35, df = 92, p-value = 0.05, X<sup>2</sup> /df = 1.24, GFI = 0.96, AGFI = 0.92, CFI = 1.00, NFI = 0.99, NNFI = 0.99, RMSEA = 0.02). The highest total effect on social dysfunction was psychotic symptoms (0.67, p<0.05). Medication use self-efficacy had a direct effect on psychotic symptoms (-0.25, p<0.01), and social support had direct effect on medication use self efficacy (0.36, p <0.01). Conclusions: Psychotic symptoms and stressful life events were the significance factors that influenced direct on social dysfunctioning. Therefore, interventions that are designed to manage these factors are crucial in order to enhance social functioning in this population.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Psychotic%20symptoms" title="Psychotic symptoms">Psychotic symptoms</a>, <a href="https://publications.waset.org/search?q=methamphetamine" title=" methamphetamine"> methamphetamine</a>, <a href="https://publications.waset.org/search?q=schizophrenia" title=" schizophrenia"> schizophrenia</a>, <a href="https://publications.waset.org/search?q=stressful%20life%20events" title=" stressful life events"> stressful life events</a>, <a href="https://publications.waset.org/search?q=social%20dysfunction" title=" social dysfunction"> social dysfunction</a>, <a href="https://publications.waset.org/search?q=social%20support" title=" social support"> social support</a>, <a href="https://publications.waset.org/search?q=medication%20use%20self-efficacy." title=" medication use self-efficacy."> medication use self-efficacy.</a> </p> <a href="https://publications.waset.org/10008670/an-acerbate-psychotics-symptoms-social-support-stressful-life-events-medication-use-self-efficacy-impact-on-social-dysfunction-a-cross-sectional-self-rated-study-of-persons-with-schizophrenia-patient-and-misusing-methamphetamines" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10008670/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10008670/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10008670/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10008670/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10008670/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10008670/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10008670/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10008670/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10008670/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10008670/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10008670.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1027</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">33</span> Analysis of Formyl Peptide Receptor 1 Protein Value as an Indicator of Neutrophil Chemotaxis Dysfunction in Aggressive Periodontitis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Prajna%20Metta">Prajna Metta</a>, <a href="https://publications.waset.org/search?q=Yanti%20Rusyanti"> Yanti Rusyanti</a>, <a href="https://publications.waset.org/search?q=Nunung%20Rusminah"> Nunung Rusminah</a>, <a href="https://publications.waset.org/search?q=Bremmy%20Laksono"> Bremmy Laksono</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>The decrease of neutrophil chemotaxis function may cause increased susceptibility to aggressive periodontitis (AP). Neutrophil chemotaxis is affected by formyl peptide receptor 1 (FPR1), which when activated will respond to bacterial chemotactic peptide formyl methionyl leusyl phenylalanine (FMLP). FPR1 protein value is decreased in response to a wide number of inflammatory stimuli in AP patients. This study was aimed to assess the alteration of FPR1 protein value in AP patients and if FPR1 protein value could be used as an indicator of neutrophil chemotaxis dysfunction in AP. This is a case control study with 20 AP patients and 20 control subjects. Three milliliters of peripheral blood were drawn and analyzed for FPR1 protein value with ELISA. The data were statistically analyzed with Mann-Whitney test (p>0,05<u>)</u>. Results showed that the mean value of FPR1 protein value in AP group is 0,353 pg/mL (0,11 to 1,18 pg/mL) and the mean value of FPR1 protein value in control group is 0,296 pg/mL (0,05 to 0,88 pg/mL). P value 0,787 > 0,05 suggested that there is no significant difference of FPR1 protein value in both groups. The present study suggests that FPR1 protein value has no significance alteration in AP patients and could not be used as an indicator of neutrophil chemotaxis dysfunction.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Aggressive%20periodontitis" title="Aggressive periodontitis">Aggressive periodontitis</a>, <a href="https://publications.waset.org/search?q=chemotaxis%20dysfunction" title=" chemotaxis dysfunction"> chemotaxis dysfunction</a>, <a href="https://publications.waset.org/search?q=FPR1%20protein%20value" title=" FPR1 protein value"> FPR1 protein value</a>, <a href="https://publications.waset.org/search?q=neutrophil." title=" neutrophil."> neutrophil.</a> </p> <a href="https://publications.waset.org/10007332/analysis-of-formyl-peptide-receptor-1-protein-value-as-an-indicator-of-neutrophil-chemotaxis-dysfunction-in-aggressive-periodontitis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10007332/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10007332/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10007332/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10007332/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10007332/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10007332/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10007332/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10007332/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10007332/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10007332/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10007332.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">841</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">32</span> High Glucose Increases Acetylcholine-Induced Ca2+ Entry and Protein Expression of STIM1</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Hong%20Ding">Hong Ding</a>, <a href="https://publications.waset.org/search?q=Fatiha%20Benslimane"> Fatiha Benslimane</a>, <a href="https://publications.waset.org/search?q=Isra%20Marei"> Isra Marei</a>, <a href="https://publications.waset.org/search?q=Chris%20R.%20Triggle"> Chris R. Triggle</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hyperglycaemia is a key factor that contributes to the development of diabetes-related microvascular disease and a major risk factor for endothelial dysfunction. In the current study, we have explored glucose-induced abnormal intracellular calcium (Ca2+ i) homeostasis in mouse microvessel endothelial cells (MMECs) in high glucose (HG) (40mmol/L) versus control (low glucose, LG) (11 mmol/L). We demonstrated that the exposure of MMECs to HG for 3 days did not change basal Ca2+ i, however, there was a significant increase of acetylcholine-induced Ca2+ entry. Western blots illustrated that exposure to HG also increased STIM1 (Stromal Interaction Molecule 1), but not Orai1 (the pore forming subunit), protein expression levels. Although the link between HG-induced changes in STIM1 expression, enhanced Ca2+ entry and endothelial dysfunction requires further study, the current data are suggestive that targeting these pathways may reduce the impact of HG on endothelial function. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=store-operated%20calcium%20entry" title="store-operated calcium entry">store-operated calcium entry</a>, <a href="https://publications.waset.org/search?q=hyperglycaemia" title=" hyperglycaemia"> hyperglycaemia</a>, <a href="https://publications.waset.org/search?q=STIM1" title=" STIM1"> STIM1</a>, <a href="https://publications.waset.org/search?q=endothelial%20dysfunction" title=" endothelial dysfunction"> endothelial dysfunction</a> </p> <a href="https://publications.waset.org/8247/high-glucose-increases-acetylcholine-induced-ca2-entry-and-protein-expression-of-stim1" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/8247/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/8247/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/8247/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/8247/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/8247/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/8247/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/8247/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/8247/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/8247/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/8247/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/8247.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1709</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">31</span> Cereals' Products with Red Grape and Walnut Extracts as Functional Foods for Prevention of Kidney Dysfunction</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Sahar%20Y.%20Al-Okbi">Sahar Y. Al-Okbi</a>, <a href="https://publications.waset.org/search?q=Doha%20A.%20Mohamed"> Doha A. Mohamed</a>, <a href="https://publications.waset.org/search?q=Thanaa%20E.%20Hamed"> Thanaa E. Hamed</a>, <a href="https://publications.waset.org/search?q=Ahmed%20Ms%20Hussein"> Ahmed Ms Hussein</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>In the present research, two nutraceuticals made from red grape and walnut that showed previously to improve kidney dysfunction were incorporated separately into functional foods' bread made from barley and rice bran. The functional foods were evaluated in rats in which chronic renal failure was induced through feeding diet rich in adenine and phosphate (APD). The evaluation based on assessing kidney function, oxidative stress, inflammatory biomarkers and body weight gain. Results showed induction of chronic kidney failure reflected in significant increase in plasma urea, creatinine, malondialdehyde, tumor necrosis factor- α and low density lipoprotein cholesterol along with significant reduction of plasma albumin, and total antioxidant and creatinine clearance and body weight gain on feeding APD compared to control healthy group. Feeding the functional foods produced amelioration in the different biochemical parameters and body weight gain indicating improvement in kidney function.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Functional%20food" title="Functional food">Functional food</a>, <a href="https://publications.waset.org/search?q=kidney%20dysfunction" title=" kidney dysfunction"> kidney dysfunction</a>, <a href="https://publications.waset.org/search?q=rats." title=" rats."> rats.</a> </p> <a href="https://publications.waset.org/16335/cereals-products-with-red-grape-and-walnut-extracts-as-functional-foods-for-prevention-of-kidney-dysfunction" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/16335/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/16335/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/16335/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/16335/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/16335/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/16335/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/16335/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/16335/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/16335/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/16335/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/16335.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2311</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">30</span> The Physiological Impacts of Genital Weightlifting Conditioning: Exploring Iron Crotch Practice for Enhanced Sexual Function, Premature Ejaculation, Penile Dysfunction, Impotence, Hormonal Balance, and Prostate Health</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=C.%20Ardil">C. Ardil</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>This study explores "Iron Crotch Kung Fu," a unique practice involving genital weightlifting. While the practice has historical significance, its potential health benefits, particularly in sexual function and overall well-being, remain largely anecdotal. To bridge the gap between tradition and modern science, this study proposes a modified Iron Crotch training program integrating principles from Pelvic Floor Muscle Training (PFMT). This integrated approach offers a safer and more effective pathway to harness the potential benefits of Iron Crotch, including enhanced sexual function, improved pelvic floor health, and increased core strength. The study delves into the historical context, technical methodologies, and potential physiological impacts of Iron Crotch, while highlighting the importance of careful practice under expert guidance. By integrating historical context, practical techniques, and scientific insights, this study aims to provide a balanced perspective on Iron Crotch and its potential role in modern health and wellness practices.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Iron%20Crotch" title="Iron Crotch">Iron Crotch</a>, <a href="https://publications.waset.org/search?q=iron%20crotch%20kung%20fu" title=" iron crotch kung fu"> iron crotch kung fu</a>, <a href="https://publications.waset.org/search?q=Diao%20Gung" title=" Diao Gung"> Diao Gung</a>, <a href="https://publications.waset.org/search?q=genital%20weightlifting" title=" genital weightlifting"> genital weightlifting</a>, <a href="https://publications.waset.org/search?q=back%20pain" title=" back pain"> back pain</a>, <a href="https://publications.waset.org/search?q=erectile%20dysfunction" title=" erectile dysfunction"> erectile dysfunction</a>, <a href="https://publications.waset.org/search?q=exercise" title=" exercise"> exercise</a>, <a href="https://publications.waset.org/search?q=exercise%20therapy" title=" exercise therapy"> exercise therapy</a>, <a href="https://publications.waset.org/search?q=female%20athletes" title=" female athletes"> female athletes</a>, <a href="https://publications.waset.org/search?q=hormonal%20balance" title=" hormonal balance"> hormonal balance</a>, <a href="https://publications.waset.org/search?q=hypertonicity" title=" hypertonicity"> hypertonicity</a>, <a href="https://publications.waset.org/search?q=martial%20arts" title=" martial arts"> martial arts</a>, <a href="https://publications.waset.org/search?q=meta-analysis" title=" meta-analysis"> meta-analysis</a>, <a href="https://publications.waset.org/search?q=overactivity" title=" overactivity"> overactivity</a>, <a href="https://publications.waset.org/search?q=pelvic%20floor" title=" pelvic floor"> pelvic floor</a>, <a href="https://publications.waset.org/search?q=pelvic%20floor%20disorders" title=" pelvic floor disorders"> pelvic floor disorders</a>, <a href="https://publications.waset.org/search?q=pelvic%20floor%20muscle%20dysfunction" title=" pelvic floor muscle dysfunction"> pelvic floor muscle dysfunction</a>, <a href="https://publications.waset.org/search?q=pelvic%20floor%20muscle%20training" title=" pelvic floor muscle training"> pelvic floor muscle training</a>, <a href="https://publications.waset.org/search?q=pelvic%20floor%20physical%20therapy" title=" pelvic floor physical therapy"> pelvic floor physical therapy</a>, <a href="https://publications.waset.org/search?q=penile%20dysfunction" title=" penile dysfunction"> penile dysfunction</a>, <a href="https://publications.waset.org/search?q=physical%20health" title=" physical health"> physical health</a>, <a href="https://publications.waset.org/search?q=physical%20medicine" title=" physical medicine"> physical medicine</a>, <a href="https://publications.waset.org/search?q=physiotherapy" title=" physiotherapy"> physiotherapy</a>, <a href="https://publications.waset.org/search?q=premature%20ejaculation" title=" premature ejaculation"> premature ejaculation</a>, <a href="https://publications.waset.org/search?q=prostate%20health" title=" prostate health"> prostate health</a>, <a href="https://publications.waset.org/search?q=provoked%20vestibulodynia" title=" provoked vestibulodynia"> provoked vestibulodynia</a>, <a href="https://publications.waset.org/search?q=resistance%20training" title=" resistance training"> resistance training</a>, <a href="https://publications.waset.org/search?q=sexual%20dysfunction" title=" sexual dysfunction"> sexual dysfunction</a>, <a href="https://publications.waset.org/search?q=sexual%20health" title=" sexual health"> sexual health</a>, <a href="https://publications.waset.org/search?q=sexual%20medicine" title=" sexual medicine"> sexual medicine</a>, <a href="https://publications.waset.org/search?q=sexual%20orientation" title=" sexual orientation"> sexual orientation</a>, <a href="https://publications.waset.org/search?q=systematic%20review" title=" systematic review"> systematic review</a>, <a href="https://publications.waset.org/search?q=traditional%20health%20practices" title=" traditional health practices"> traditional health practices</a>, <a href="https://publications.waset.org/search?q=urinary%20incontinence" title=" urinary incontinence"> urinary incontinence</a>, <a href="https://publications.waset.org/search?q=urodynamics" title=" urodynamics"> urodynamics</a>, <a href="https://publications.waset.org/search?q=vaginismus" title=" vaginismus"> vaginismus</a>, <a href="https://publications.waset.org/search?q=vestibulodynia" title=" vestibulodynia"> vestibulodynia</a>, <a href="https://publications.waset.org/search?q=women%E2%80%99s%20health" title=" women’s health"> women’s health</a>, <a href="https://publications.waset.org/search?q=PFMT" title=" PFMT"> PFMT</a> </p> <a href="https://publications.waset.org/10013879/the-physiological-impacts-of-genital-weightlifting-conditioning-exploring-iron-crotch-practice-for-enhanced-sexual-function-premature-ejaculation-penile-dysfunction-impotence-hormonal-balance-and-prostate-health" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10013879/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10013879/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10013879/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10013879/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10013879/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10013879/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10013879/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10013879/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10013879/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10013879/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10013879.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">47</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">29</span> Status of Thyroid Function and Iron Overload in Adolescents and Young Adults with Beta- Thalassemia Major Treated with Deferoxamine in Jordan</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Fawzi%20Irshaid">Fawzi Irshaid</a>, <a href="https://publications.waset.org/search?q=Kamal%20Mansi"> Kamal Mansi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Thyroid dysfunction is one of the most frequently reported complications of chronic blood transfusion therapy in patients with beta-thalassemia major (BTM). However, the occurrence of thyroid dysfunction and its possible association with iron overload in BTM patients is still under debate. Therefore, this study aimed to investigate the status of thyroid functions and iron overload in adolescent and young adult patients with BTM in Jordan population. Thirty six BTM patients aged 12-28 years and matched controls were included in this study. All patients have been receiving frequent blood transfusion to maintain pretransfusion hemoglobin concentration above 10 g dl-1 and deferoxamine at a dose of 45 mg kg-1 day-1 (8 h, 5-7 days/week) by subcutaneous infusion. Blood samples were drawn from patients and controls. The status of thyroid functions and iron overload was evaluated by measurements of serum free thyroxine (FT4), triiodothyronine (FT3), thyrotropin (TSH) and serum ferritin level. A number of some hematological and biochemical parameters were also measured. It was found that hematocrit, serum ferritin, hemoglobin, FT3 and zinc, copper mean values were significantly higher in the patients than in the controls (P< 0.05). On other hand, leukocyte, FT4 and TSH mean values were similar to that of the controls. In addition, our data also indicated that all of the above examined parameters were not significantly affected by the patient-s age and gender. Deferoxamine approach for removing excess iron from our BTM patient did not normalize the values of serum ferritin, copper and zinc, suggesting poor compliance with deferoxamine chelation therapy. Thus, we recommend the use of a combination of deferoxamine and deferiprone to reduce the risk of excess of iron in our patients. Furthermore, thyroid dysfunction appears to be a rare complication, because our patients showed normal mean levels for serum TSH and FT4. However, high mean levels of serum ferritin, zinc, copper might be seen as potential risk factors for initiation and development of thyroid dysfunctions and other diseases. Therefore, further studies must be carried out at yearly intervals with large sample number, to detect subclinical thyroid dysfunction cases. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=beta-thalassemia%20major" title="beta-thalassemia major">beta-thalassemia major</a>, <a href="https://publications.waset.org/search?q=deferoxamine" title=" deferoxamine"> deferoxamine</a>, <a href="https://publications.waset.org/search?q=iron%20overload" title=" iron overload"> iron overload</a>, <a href="https://publications.waset.org/search?q=triiodothyronine" title=" triiodothyronine"> triiodothyronine</a>, <a href="https://publications.waset.org/search?q=zinc." title=" zinc."> zinc.</a> </p> <a href="https://publications.waset.org/13007/status-of-thyroid-function-and-iron-overload-in-adolescents-and-young-adults-with-beta-thalassemia-major-treated-with-deferoxamine-in-jordan" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/13007/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/13007/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/13007/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/13007/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/13007/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/13007/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/13007/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/13007/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/13007/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/13007/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/13007.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1826</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">28</span> Evaluation of Antiglycation Effects of Extracts Obtained from Canarium album Raeusch Fruit and Beneficial Activity on Advanced Glycation Endproduct-Mediated Oxidative Stress and Inflammation in Monocytes and Vascular Endothelial Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Chiung-Tsun%20Kuoa">Chiung-Tsun Kuoa</a>, <a href="https://publications.waset.org/search?q=Tzu-Hao%20Liu"> Tzu-Hao Liu</a>, <a href="https://publications.waset.org/search?q=Fang-Yi%20Lin"> Fang-Yi Lin</a>, <a href="https://publications.waset.org/search?q=Tai-Hao%20Hsu"> Tai-Hao Hsu</a>, <a href="https://publications.waset.org/search?q=Hui-Yin%20Chen"> Hui-Yin Chen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Hyperglycemia-mediated accumulation of advanced glycation end-products (AGEs) play a pivotal role in the development of diabetic complications by inducing inflammation. In the present study, we evaluated the possible effects of water/ethanol (1/1, v/v) extracts (WEE) and its fractions from Canarium album Raeusch. (Chinese olive) which is a fruit used on AGEs-stimulated oxidative stress and inflammation in monocytes and vascular endothelial cells. Co-incubation of EA.hy926 endothelial cells with WEE and its fractions for 24h resulted in a significant decrease of monocyte–endothelial cell adhesion, the expression of ICAM-1, generation of intracellular ROS and depletion of GSH induced by AGEs. Chinese olive fruit extracts also reduced the expression of pro-inflammatory mediates, such as TNF-α, IL-1β and IL-6 in THP-1 cells. These findings suggested that Chinese olive fruit was able to protect vascular endothelium from dysfunction induced by AGEs. </p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Advanced%20glycation%20end-products%20%28AGEs%29" title="Advanced glycation end-products (AGEs)">Advanced glycation end-products (AGEs)</a>, <a href="https://publications.waset.org/search?q=Canarium%0D%0Aalbum%20Raeusch" title=" Canarium album Raeusch"> Canarium album Raeusch</a>, <a href="https://publications.waset.org/search?q=endothelial%20dysfunction" title=" endothelial dysfunction"> endothelial dysfunction</a>, <a href="https://publications.waset.org/search?q=inflammation." title=" inflammation."> inflammation.</a> </p> <a href="https://publications.waset.org/16287/evaluation-of-antiglycation-effects-of-extracts-obtained-from-canarium-album-raeusch-fruit-and-beneficial-activity-on-advanced-glycation-endproduct-mediated-oxidative-stress-and-inflammation-in-monocytes-and-vascular-endothelial-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/16287/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/16287/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/16287/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/16287/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/16287/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/16287/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/16287/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/16287/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/16287/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/16287/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/16287.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1674</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">27</span> Neurological Manifestations in Patients with HIV Infection in the Era of Combined Antiretroviral Therapy </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Sharan%20Badiger">Sharan Badiger</a>, <a href="https://publications.waset.org/search?q=Prema%20T.%20Akkasaligar"> Prema T. Akkasaligar</a>, <a href="https://publications.waset.org/search?q=Deepak%20Kadeli"> Deepak Kadeli</a>, <a href="https://publications.waset.org/search?q=M.%20Vishok"> M. Vishok </a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Neurological disorders are the most debilitating of manifestations seen in patients infected with HIV. The clinical profile of neurological manifestations in HIV patients has undergone a shift in recent years with opportunistic infections being controlled with combination anti-retroviral therapy and the advent of drugs which have higher central nervous system penetrability. The aim of this paper is to study the clinical, investigation profile and various neurological disorders in HIV patients on anti‐retroviral therapy. Fifty HIV patients with neurological manifestations were studied. A complete neurological examination including neurocognitive functioning using Montreal Cognitive Assessment and HIV Dementia scale were assessed. Apart from relevant investigations, CD4 count, cerebrovascular fluid analysis, computed tomography (CT) and magnetic resonance imaging (MRI) of brain were done whenever required. Neurocognitive disorders formed the largest group with 42% suffering from HIV associated Neurocognitive Disorders. Among them, asymptomatic neurocognitive impairment was seen in 28%; mild neurocognitive disorder in 12%, and 2% had HIV‐associated dementia. Opportunistic infections of the nervous system accounted for 32%, with meningitis being the most common. Four patients had space occupying lesions of central nervous system; four tuberculomas, and one toxoplasmosis. With the advent of highly active retroviral therapy, HIV patients have longer life spans with suppression of viral load leading to decrease in opportunistic infections of the nervous system. Neurocognitive disorders are now the most common neurological dysfunction seen and thus neurocognitive assessment must be done in all patients with HIV.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Anti%20retroviral%20therapy" title="Anti retroviral therapy">Anti retroviral therapy</a>, <a href="https://publications.waset.org/search?q=cognitive%20dysfunction" title=" cognitive dysfunction"> cognitive dysfunction</a>, <a href="https://publications.waset.org/search?q=dementia" title=" dementia"> dementia</a>, <a href="https://publications.waset.org/search?q=neurological%20manifestations" title=" neurological manifestations"> neurological manifestations</a>, <a href="https://publications.waset.org/search?q=opportunistic%20infections." title=" opportunistic infections."> opportunistic infections.</a> </p> <a href="https://publications.waset.org/10004102/neurological-manifestations-in-patients-with-hiv-infection-in-the-era-of-combined-antiretroviral-therapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10004102/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10004102/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10004102/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10004102/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10004102/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10004102/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10004102/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10004102/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10004102/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10004102/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10004102.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1668</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">26</span> New Echocardiographic Morphofunctional Diastolic Index (MFDI) in Differentiation of Normal Left Ventricular Filling from Pseudonormal and Restrictive</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=N.%20Nelasov">N. Nelasov</a>, <a href="https://publications.waset.org/search?q=D.%20Safonov"> D. Safonov</a>, <a href="https://publications.waset.org/search?q=M.%20Babaev"> M. Babaev</a>, <a href="https://publications.waset.org/search?q=E.%20Mirzojan"> E. Mirzojan</a>, <a href="https://publications.waset.org/search?q=O.%20Eroshenko"> O. Eroshenko</a>, <a href="https://publications.waset.org/search?q=M.%20Morgunov"> M. Morgunov</a>, <a href="https://publications.waset.org/search?q=A.%20Erofeeva"> A. Erofeeva </a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>We have shown previously that reflected high intensity motion signals (RIMS) can be used for detection of left ventricular (LV) diastolic dysfunction (DD). It is also well known, that left atrial (LA) dimension can be used as a marker of DD. In this study we decided to analyze the diagnostic role of new echocardiographic morphofunctional diastolic index (MFDI) in differentiation of normal filling of LV from pseudonormal and restrictive. MFDI includes LA dimension and velocity of early diastolic component ea of RIMS (MFDI = LA/ea).  </p> <p>343 healthy subjects and patients with various cardiac pathology underwent dopplerechocardiographic exam. According to the criteria of "Don" classification scheme 155 subjects had signs of normal LV filling (N) and 55 - of pseudonormal and restrictive filling (PN + R). LA dimension was performed in standard manner. RIMS were registered by conventional pulsed wave Doppler from apical 4-chamber view, when the sample volume was positioned between the tips of mitral leaflets. The velocity of early diastolic component of RIMS was measured. After calculation of MFDI mean values of this index in two groups (N and PN + R) were compared. The cutoff value of MFDI for differentiation of patients with N and PN + R was determined.</p> <p>Mean value of MFDI in subjects with normal filling was 1.38<u>+</u>0.33 and in patients with pseudonormal and restrictive filling 2.43<u>+</u>0.43; p<0.0001. The cutoff value of MFDI > 2.0 separated subjects with normal LV filling from subjects with pseudonormal and restrictive filling with sensitivity 89.1% and specificity 97.4%.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Dopplerechocardiography" title="Dopplerechocardiography">Dopplerechocardiography</a>, <a href="https://publications.waset.org/search?q=diastolic%20dysfunction" title=" diastolic dysfunction"> diastolic dysfunction</a>, <a href="https://publications.waset.org/search?q=left%20atrium" title=" left atrium"> left atrium</a>, <a href="https://publications.waset.org/search?q=reflected%20high%20intensity%20motion%20signals." title=" reflected high intensity motion signals. "> reflected high intensity motion signals. </a> </p> <a href="https://publications.waset.org/9996803/new-echocardiographic-morphofunctional-diastolic-index-mfdi-in-differentiation-of-normal-left-ventricular-filling-from-pseudonormal-and-restrictive" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/9996803/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/9996803/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/9996803/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/9996803/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/9996803/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/9996803/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/9996803/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/9996803/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/9996803/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/9996803/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/9996803.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1590</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25</span> Protection Plan of Medium Voltage Distribution Network in Tunisia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=S.%20Chebbi">S. Chebbi</a>, <a href="https://publications.waset.org/search?q=A.%20Meddeb"> A. Meddeb</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>The distribution networks are often exposed to harmful incidents which can halt the electricity supply of the customer. In this context, we studied a real case of a critical zone of the Tunisian network which is currently characterized by the dysfunction of its plan of protection. In this paper, we were interested in the harmonization of the protection plan settings in order to ensure a perfect selectivity and a better continuity of service on the whole of the network.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Distribution%20network%20Gabes-Tunisia" title="Distribution network Gabes-Tunisia">Distribution network Gabes-Tunisia</a>, <a href="https://publications.waset.org/search?q=NEPLAN%C2%A9DACH" title=" NEPLAN©DACH"> NEPLAN©DACH</a>, <a href="https://publications.waset.org/search?q=protection%20plan%20settings" title=" protection plan settings"> protection plan settings</a>, <a href="https://publications.waset.org/search?q=selectivity." title=" selectivity."> selectivity.</a> </p> <a href="https://publications.waset.org/10000628/protection-plan-of-medium-voltage-distribution-network-in-tunisia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10000628/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10000628/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10000628/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10000628/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10000628/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10000628/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10000628/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10000628/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10000628/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10000628/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10000628.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2958</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">24</span> Physicochemical Activities of Blood Biomarkers Due to Ingestible Radon-222 in Drinking Water and Its Associated Health Consequences</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=I.%20M.%20Yusuff">I. M. Yusuff</a>, <a href="https://publications.waset.org/search?q=A.%20M.%20Arogunjo"> A. M. Arogunjo</a>, <a href="https://publications.waset.org/search?q=S.%20B.%20Ibikunle"> S. B. Ibikunle</a>, <a href="https://publications.waset.org/search?q=O.%20M.%20Oni"> O. M. Oni</a>, <a href="https://publications.waset.org/search?q=P.%20O.%20Osho"> P. O. Osho</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Generally, water contamination is a serious health concern, affecting millions of people worldwide every year. Among the water contaminants, radon is a radioactive contaminant understudied and under-regulated. It produces many adverse health effects, including cancer. It is a natural gas that cannot be seen, tasted, or smelled. It develops from the radioactive decay of radium found in the rock of soil and has been considered a health hazard due to its radioactivity in nature. To examine its effects and physicochemical characteristics on the blood biomarkers due to its ingestion in drinking water, its concentrations were monitored and measured in treated and untreated water using Electronic Radon Active Detector (RAD7), while human blood samples were collected using the required laboratory tools. The blood samples were collected and examined physicochemically using semi-automated chemistry analyzer to evaluate the chemistry parameters of the blood. Statistically, results obtained were analyzed using T-test of variables at 95% confidence interval. The outcome of results revealed 112.03 Bq/m3, 561.67 Bq/m3 and 2,753.00 Bq/m3 of radon-222 concentrations in the three water samples used respectively. Demographically, chemistry parameters biomarkers of the blood determined displayed some levels of variations due to radon-222 contaminants ingested from untreated water. Also, analyzed results of blood revealed the associations between the physicochemical parameters of the blood biomarkers and volunteers’ health consequences. The consequences observed were more severed with group B volunteers than group A, due to high level of radon contaminants in borehole water consumed by group B than in well water consumed by group A. The percentages of elevated and depressed biomarkers observed differ from initial reference values and, were the dysfunction indicators. They are directly or indirectly associated to human’s state of health. Most significant biomarkers affected were; HCO3, Cl, K, Cr and Na, they are relevant biomarkers in medicine to determine human’s state of health at any point in time.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Radioactive" title="Radioactive">Radioactive</a>, <a href="https://publications.waset.org/search?q=radon" title=" radon"> radon</a>, <a href="https://publications.waset.org/search?q=biomarker" title=" biomarker"> biomarker</a>, <a href="https://publications.waset.org/search?q=ingestion" title=" ingestion"> ingestion</a>, <a href="https://publications.waset.org/search?q=dysfunction." title=" dysfunction."> dysfunction.</a> </p> <a href="https://publications.waset.org/10013424/physicochemical-activities-of-blood-biomarkers-due-to-ingestible-radon-222-in-drinking-water-and-its-associated-health-consequences" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10013424/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10013424/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10013424/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10013424/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10013424/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10013424/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10013424/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10013424/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10013424/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10013424/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10013424.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">212</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">23</span> A Review of Pharmacological Prevention of Peri-and Post-Procedural Myocardial Injury after Percutaneous Coronary Intervention</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Syed%20Dawood%20Md.%20Taimur">Syed Dawood Md. Taimur</a>, <a href="https://publications.waset.org/search?q=Md.%20Hasanur%20Rahman"> Md. Hasanur Rahman</a>, <a href="https://publications.waset.org/search?q=Syeda%20Fahmida%20Afrin"> Syeda Fahmida Afrin</a>, <a href="https://publications.waset.org/search?q=Farzana%20Islam"> Farzana Islam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>The concept of myocardial injury, although first recognized from animal studies, is now recognized as a clinical phenomenon that may result in microvascular damage, no-reflow phenomenon, myocardial stunning, myocardial hibernation and ischemic preconditioning. The final consequence of this event is left ventricular (LV) systolic dysfunction leading to increased morbidity and mortality. The typical clinical case of reperfusion injury occurs in acute myocardial infarction (MI) with ST segment elevation in which an occlusion of a major epicardial coronary artery is followed by recanalization of the artery. This may occur spontaneously or by means of thrombolysis and/or by primary percutaneous coronary intervention (PCI) with efficient platelet inhibition by aspirin (acetylsalicylic acid), clopidogrel and glycoprotein IIb/IIIa inhibitors. In recent years, percutaneous coronary intervention (PCI) has become a well-established technique for the treatment of coronary artery disease. PCI improves symptoms in patients with coronary artery disease and it has been increasing safety of procedures. However, peri- and post-procedural myocardial injury, including angiographical slow coronary flow, microvascular embolization, and elevated levels of cardiac enzyme, such as creatine kinase and troponin-T and -I, has also been reported even in elective cases. Furthermore, myocardial reperfusion injury at the beginning of myocardial reperfusion, which causes tissue damage and cardiac dysfunction, may occur in cases of acute coronary syndrome. Because patients with myocardial injury is related to larger myocardial infarction and have a worse long-term prognosis than those without myocardial injury, it is important to prevent myocardial injury during and/or after PCI in patients with coronary artery disease. To date, many studies have demonstrated that adjunctive pharmacological treatment suppresses myocardial injury and increases coronary blood flow during PCI procedures. In this review, we highlight the usefulness of pharmacological treatment in combination with PCI in attenuating myocardial injury in patients with coronary artery disease.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Coronary%20artery%20disease" title="Coronary artery disease">Coronary artery disease</a>, <a href="https://publications.waset.org/search?q=Percutaneous%20coronary%20intervention" title=" Percutaneous coronary intervention"> Percutaneous coronary intervention</a>, <a href="https://publications.waset.org/search?q=Myocardial%20injury" title=" Myocardial injury"> Myocardial injury</a>, <a href="https://publications.waset.org/search?q=Pharmacology." title=" Pharmacology."> Pharmacology.</a> </p> <a href="https://publications.waset.org/9996941/a-review-of-pharmacological-prevention-of-peri-and-post-procedural-myocardial-injury-after-percutaneous-coronary-intervention" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/9996941/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/9996941/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/9996941/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/9996941/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/9996941/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/9996941/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/9996941/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/9996941/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/9996941/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/9996941/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/9996941.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2329</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">22</span> Microalbuminuria in Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Sharan%20Badiger">Sharan Badiger</a>, <a href="https://publications.waset.org/search?q=Prema%20T.%20Akkasaligar"> Prema T. Akkasaligar</a>, <a href="https://publications.waset.org/search?q=Patil%20LS"> Patil LS</a>, <a href="https://publications.waset.org/search?q=Manish%20Patel"> Manish Patel</a>, <a href="https://publications.waset.org/search?q=Biradar%20MS"> Biradar MS</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Human immunodeficiency virus infection and acquired immunodeficiency syndrome is a global pandemic with cases reporting from virtually every country and continues to be a common infection in developing country like India. Microalbuminuria is a manifestation of human immunodeficiency virus associated nephropathy. Therefore, microalbuminuria may be an early marker of human immunodeficiency virus associated nephropathy, and screening for its presence may be beneficial. A strikingly high prevalence of microalbuminuria among human immunodeficiency virus infected patients has been described in various studies. Risk factors for clinically significant proteinuria include African - American race, higher human immunodeficiency virus ribonucleic acid level and lower CD4 lymphocyte count. The cardiovascular risk factors of increased systolic blood pressure and increase fasting blood sugar level are strongly associated with microalbuminuria in human immunodeficiency virus patient. These results suggest that microalbuminuria may be a sign of current endothelial dysfunction and micro-vascular disease and there is substantial risk of future cardiovascular disease events. Positive contributing factors include early kidney disease such as human immunodeficiency virus associated nephropathy, a marker of end organ damage related to co morbidities of diabetes or hypertension, or more diffuse endothelial cells dysfunction. Nevertheless after adjustment for non human immunodeficiency virus factors, human immunodeficiency virus itself is a major risk factor. The presence of human immunodeficiency virus infection is independent risk to develop microalbuminuria in human immunodeficiency virus patient. Cardiovascular risk factors appeared to be stronger predictors of microalbuminuria than markers of human immunodeficiency virus severity person with human immunodeficiency virus infection and microalbuminuria therefore appear to potentially bear the burden of two separate damage related to known vascular end organ damage related to know vascular risk factors, and human immunodeficiency virus specific processes such as the direct viral infection of kidney cells.The higher prevalence of microalbuminuria among the human immunodeficiency virus infected could be harbinger of future increased risks of both kidney and cardiovascular disease. Further study defining the prognostic significance of microalbuminuria among human immunodeficiency virus infected persons will be essential. Microalbuminuria seems to be a predictor of cardiovascular disease in diabetic and non diabetic subjects, hence it can also be used for early detection of micro vascular disease in human immunodeficiency virus positive patients, thus can help to diagnose the disease at the earliest. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Acquired%20immunodeficiency%20syndrome" title="Acquired immunodeficiency syndrome">Acquired immunodeficiency syndrome</a>, <a href="https://publications.waset.org/search?q=Human%0Aimmunodeficiency%20virus" title=" Human immunodeficiency virus"> Human immunodeficiency virus</a>, <a href="https://publications.waset.org/search?q=Microalbuminuria." title=" Microalbuminuria."> Microalbuminuria.</a> </p> <a href="https://publications.waset.org/6688/microalbuminuria-in-human-immunodeficiency-virus-infection-and-acquired-immunodeficiency-syndrome" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/6688/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/6688/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/6688/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/6688/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/6688/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/6688/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/6688/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/6688/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/6688/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/6688/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/6688.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1920</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">21</span> Outcomes of Pregnancy in Women with TPO Positive Status after Appropriate Dose Adjustments of Thyroxin: A Prospective Cohort Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Revathi%20S.%20Rajan">Revathi S. Rajan</a>, <a href="https://publications.waset.org/search?q=Pratibha%20Malik"> Pratibha Malik</a>, <a href="https://publications.waset.org/search?q=Nupur%20Garg"> Nupur Garg</a>, <a href="https://publications.waset.org/search?q=Smitha%20Avula"> Smitha Avula</a>, <a href="https://publications.waset.org/search?q=Kamini%20A.%20Rao"> Kamini A. Rao</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>This study aimed to analyse the pregnancy outcomes in patients with TPO positivity after appropriate L-Thyroxin supplementation with close surveillance. All pregnant women attending the antenatal clinic at Milann-The Fertility Center, Bangalore, India- from Aug 2013 to Oct 2014 whose booking TSH was more than 2.5 mIU/L were included along with those pregnant women with prior hypothyroidism who were TPO positive. Those with TPO positive status were vigorously managed with appropriate thyroxin supplementation and the doses were readjusted every 3 to 4 weeks until delivery. Women with recurrent pregnancy loss were also tested for TPO positivity and if tested positive, were monitored serially with TSH and fT4 levels every 3 to 4 weeks and appropriately supplemented with thyroxin when the levels fluctuated. The testing was done after an informed consent in all these women. The statistical software namely SAS 9.2, SPSS 15.0, Stata 10.1, MedCalc 9.0.1, Systat 12.0 and R environment ver.2.11.1 were used for the analysis of the data. 460 pregnant women were screened for thyroid dysfunction at booking of which 52% were hypothyroid. Majority of them (31.08%) were subclinically hypothyroid and the remaining were overt. 25% of the total no. of patients screened were TPO positive. The various pregnancy complications that were observed in the TPO positive women were gestational glucose intolerance [60%], threatened abortion [21%], midtrimester abortion [4.3%], premature rupture of membranes [4.3%], cervical funneling [4.3%] and fetal growth restriction [3.5%]. 95.6% of the patients who followed up till the end delivered beyond 30 weeks. 42.6% of these patients had previous history of recurrent abortions or adverse obstetric outcome and 21.7% of the delivered babies required NICU admission. Obstetric outcomes in our study in terms of midtrimester abortions, placental abruption, and preterm delivery improved for the better after close monitoring of the thyroid hormone [TSH and fT4] levels every 3 to 4 weeks with appropriate dose adjustment throughout pregnancy. Euthyroid women with TPO positive status enrolled in the study incidentally were those with recurrent abortions/infertility and required thyroxin supplements due to elevated Thyroid hormone (TSH, fT4) levels during the course of their pregnancy. Significant associations were found with age>30 years and Hyperhomocysteinemia [p=0.017], recurrent pregnancy loss or previous adverse obstetric outcomes [p=0.067] and APLA [p=0.029]. TPO antibody levels >600 I U/ml were significantly associated with development of gestational hypertension [p=0.041] and fetal growth restriction [p=0.082]. Euthyroid women with TPO positivity were also screened periodically to counter fluctuations of the thyroid hormone levels with appropriate thyroxin supplementation. Thus, early identification along with aggressive management of thyroid dysfunction and stratification of these patients based on their TPO status with appropriate thyroxin supplementation beginning in the first trimester will aid risk modulation and also help avert complications.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Antinuclear%20antibody" title="Antinuclear antibody">Antinuclear antibody</a>, <a href="https://publications.waset.org/search?q=Subclinical%20hypothyroidism" title=" Subclinical hypothyroidism"> Subclinical hypothyroidism</a>, <a href="https://publications.waset.org/search?q=Thyroxin" title=" Thyroxin"> Thyroxin</a>, <a href="https://publications.waset.org/search?q=TPO%20antibody." title=" TPO antibody."> TPO antibody.</a> </p> <a href="https://publications.waset.org/10003856/outcomes-of-pregnancy-in-women-with-tpo-positive-status-after-appropriate-dose-adjustments-of-thyroxin-a-prospective-cohort-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10003856/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10003856/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10003856/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10003856/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10003856/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10003856/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10003856/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10003856/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10003856/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10003856/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10003856.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1706</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">20</span> Acute Myocardial Infarction Associated with Ingestion of Herbal Mixtures Containing Acetylcholinesterase Inhibitors: A Case Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=M.%20Hakami">M. Hakami</a>, <a href="https://publications.waset.org/search?q=A.%20Jammaly"> A. Jammaly</a>, <a href="https://publications.waset.org/search?q=I.%20Attafi"> I. Attafi</a>, <a href="https://publications.waset.org/search?q=M.%20Oraiby"> M. Oraiby</a>, <a href="https://publications.waset.org/search?q=M.%20Jeraiby"> M. Jeraiby</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We reviewed an unusual case of a 65-year-old male taking an herbal mixture containing compounds with anticholinesterase activity for a long period of time, presented with acute my myocardial infarction and multiple organ dysfunction syndrome followed by death. Clinically, there are findings correlated with anticholinesterase activity, such as bilateral miosis, diaphoresis, vomiting and fasciculation without a history of any toxic ingestion or exposure. Gas chromatography–mass spectrometry screening studies identified the presence of thymol, anethole in the herbal extract and butylated hydroxytoluene in the blood sample. Hence, with this case report, we intend to highlight the necessity of evaluating the long-term use of the herbal mixture. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Cholinesterase%20inhibitors" title="Cholinesterase inhibitors">Cholinesterase inhibitors</a>, <a href="https://publications.waset.org/search?q=thymol" title=" thymol"> thymol</a>, <a href="https://publications.waset.org/search?q=anethole" title=" anethole"> anethole</a>, <a href="https://publications.waset.org/search?q=butylated%20hydroxytoluene" title=" butylated hydroxytoluene"> butylated hydroxytoluene</a>, <a href="https://publications.waset.org/search?q=cardiac%20toxicity%20and%20myocardial%20infarction." title=" cardiac toxicity and myocardial infarction."> cardiac toxicity and myocardial infarction.</a> </p> <a href="https://publications.waset.org/10006815/acute-myocardial-infarction-associated-with-ingestion-of-herbal-mixtures-containing-acetylcholinesterase-inhibitors-a-case-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10006815/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10006815/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10006815/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10006815/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10006815/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10006815/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10006815/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10006815/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10006815/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10006815/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10006815.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1033</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">19</span> Quantification of Heart Rate Variability: A Measure based on Unique Heart Rates</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=V.%20I.%20Thajudin%20Ahamed">V. I. Thajudin Ahamed</a>, <a href="https://publications.waset.org/search?q=P.%20Dhanasekaran"> P. Dhanasekaran</a>, <a href="https://publications.waset.org/search?q=A.%20Naseem"> A. Naseem</a>, <a href="https://publications.waset.org/search?q=N.%20G.%20Karthick"> N. G. Karthick</a>, <a href="https://publications.waset.org/search?q=T.%20K.%20Abdul%20Jaleel"> T. K. Abdul Jaleel</a>, <a href="https://publications.waset.org/search?q=Paul%20K.Joseph"> Paul K.Joseph</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>It is established that the instantaneous heart rate (HR) of healthy humans keeps on changing. Analysis of heart rate variability (HRV) has become a popular non invasive tool for assessing the activities of autonomic nervous system. Depressed HRV has been found in several disorders, like diabetes mellitus (DM) and coronary artery disease, characterised by autonomic nervous dysfunction. A new technique, which searches for pattern repeatability in a time series, is proposed specifically for the analysis of heart rate data. These set of indices, which are termed as pattern repeatability measure and pattern repeatability ratio are compared with approximate entropy and sample entropy. In our analysis, based on the method developed, it is observed that heart rate variability is significantly different for DM patients, particularly for patients with diabetic foot ulcer.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Autonomic%20nervous%20system" title="Autonomic nervous system">Autonomic nervous system</a>, <a href="https://publications.waset.org/search?q=diabetes%20mellitus" title=" diabetes mellitus"> diabetes mellitus</a>, <a href="https://publications.waset.org/search?q=heart%0D%0Arate%20variability" title=" heart rate variability"> heart rate variability</a>, <a href="https://publications.waset.org/search?q=pattern%20identification" title=" pattern identification"> pattern identification</a>, <a href="https://publications.waset.org/search?q=sample%20entropy" title=" sample entropy"> sample entropy</a> </p> <a href="https://publications.waset.org/10585/quantification-of-heart-rate-variability-a-measure-based-on-unique-heart-rates" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10585/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10585/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10585/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10585/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10585/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10585/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10585/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10585/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10585/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10585/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10585.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1910</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">18</span> Pulse Oximeter Concept for Vascular Occlusion Test </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Fatanah%20M.%20Suhaimi">Fatanah M. Suhaimi</a>, <a href="https://publications.waset.org/search?q=J.%20Geoffrey%20Chase"> J. Geoffrey Chase</a>, <a href="https://publications.waset.org/search?q=Christopher%20G.%20Pretty"> Christopher G. Pretty</a>, <a href="https://publications.waset.org/search?q=Rodney%20Elliott"> Rodney Elliott</a>, <a href="https://publications.waset.org/search?q=Geoffrey%20M.%20Shaw"> Geoffrey M. Shaw</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Microcirculatory dysfunction is very common in sepsis and may results in organ failure and increased risk of death. Analyzing oxygen utilization can potentially assess microcirculation function of an individual. In this study, a modified pulse oximeter is used to extract information signals due to absorption of red (R) and infrared (IR) light. IR and R signal are related to the overall blood volume and reduced hemoglobin, respectively. Differences between these two signals thus represent the amount of oxygenated hemoglobin. Avascular occlusion test has been conducted on healthy individuals to validate the pulse oximeter concept. In this test, both R and IR signals rapidly changed according to the occlusion process. The pulse oximeter concept presented is capable of extracting valuable information to assess microcirculation condition. Implementing this concept on ICU patients has the potential to aid sepsis diagnosis and provide more accurate tracking of patient state and sepsis status.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Microcirculation" title="Microcirculation">Microcirculation</a>, <a href="https://publications.waset.org/search?q=sepsis" title=" sepsis"> sepsis</a>, <a href="https://publications.waset.org/search?q=sepsis%20diagnosis" title=" sepsis diagnosis"> sepsis diagnosis</a>, <a href="https://publications.waset.org/search?q=oxygen%20extraction." title=" oxygen extraction. "> oxygen extraction. </a> </p> <a href="https://publications.waset.org/17254/pulse-oximeter-concept-for-vascular-occlusion-test" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/17254/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/17254/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/17254/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/17254/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/17254/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/17254/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/17254/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/17254/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/17254/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/17254/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/17254.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2032</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">17</span> Sexual Health and Reproductive Ageing among Rural Women of Marrakech (Morocco)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=R.%20Lotfi">R. Lotfi</a>, <a href="https://publications.waset.org/search?q=M.%20Loukid"> M. Loukid</a>, <a href="https://publications.waset.org/search?q=M.K.%20Hilali"> M.K. Hilali</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>The reproductive aging of women is a biological process which is expressed by the loss of ovarian function and therefore the loss of the possibility of procreation. The present work aims to evaluate the effect of menopause on sexual health of rural women and to examine the determinants of female sexuality after menopause. A survey was conducted among 527 women in the rural area of Marrakech. The average age of women was 51.92 ± 7.24 years. It appears from this study that sexual activity in menopausal women decreases with age, 20% of women had no sexual activity after menopause. 72% of respondents reported having sex by obligation, 71% of women say they are not satisfied with their sexuality, while 29 % are very satisfied. The most common sexual complaints are represented by the decreased libido (81%), vaginal dryness (54%), and pain (22,7%). Of the 511 women with sexual dysfunction, only 34 (6, 4%) consulted for this disorder. Many factors may influence sex include menopause and all the biological changes but also the roles of culture, social constructions and perception of sexuality after menopause are complicated.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Keywords%E2%80%94Reproductive%20aging" title="Keywords—Reproductive aging">Keywords—Reproductive aging</a>, <a href="https://publications.waset.org/search?q=menopause" title=" menopause"> menopause</a>, <a href="https://publications.waset.org/search?q=sexuality" title=" sexuality"> sexuality</a>, <a href="https://publications.waset.org/search?q=rural%0D%0Awomen." title=" rural women."> rural women.</a> </p> <a href="https://publications.waset.org/16704/sexual-health-and-reproductive-ageing-among-rural-women-of-marrakech-morocco" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/16704/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/16704/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/16704/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/16704/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/16704/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/16704/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/16704/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/16704/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/16704/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/16704/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/16704.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1757</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> Comparison of Proportional Control and Fuzzy Logic Control to Develop an Ideal Thermoelectric Renal Hypothermia System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Hakan%20I%C5%9F%C4%B1k">Hakan Işık</a>, <a href="https://publications.waset.org/search?q=Esra%20Sara%C3%A7o%C4%9Flu"> Esra Saraçoğlu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, a comparison of two control methods, Proportional Control (PC) and Fuzzy Logic Control (FLC), which have been used to develop an ideal thermoelectric renal hypothermia system in order to use in renal surgery, has been carried out. Since the most important issues in long-lasting parenchymatous renal surgery are to provide an operation medium free of blood and to prevent renal dysfunction in the postoperative period, control of the temperature has become very important in renal surgery. The final product is seriously affected from the changes in temperature, therefore, it is necessary to reach some desired temperature points quickly and avoid large overshoot. PIC16F877 microcontroller has been used as controller for both of these two methods. Each control method can simply ensure extra renal hypothermia in the targeted way. But investigation of advantages and disadvantages of every control method to each other is aimed and carried out by the experimental implementations. Shortly, investigation of the most appropriate method to use for development of system and that can be applied to people safely in the future, has been performed. In this sense, experimental results show that fuzzy logic control gives out more reliable responses and efficient performance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=renal%20hypothermia" title="renal hypothermia">renal hypothermia</a>, <a href="https://publications.waset.org/search?q=renal%20cooling" title=" renal cooling"> renal cooling</a>, <a href="https://publications.waset.org/search?q=temperature%20control" title=" temperature control"> temperature control</a>, <a href="https://publications.waset.org/search?q=proportional%20control%20fuzzy%20logic%20control" title="proportional control fuzzy logic control">proportional control fuzzy logic control</a> </p> <a href="https://publications.waset.org/15459/comparison-of-proportional-control-and-fuzzy-logic-control-to-develop-an-ideal-thermoelectric-renal-hypothermia-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/15459/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/15459/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/15459/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/15459/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/15459/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/15459/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/15459/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/15459/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/15459/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/15459/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/15459.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1462</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> In vitro and in vivo Assessment of Cholinesterase Inhibitory Activity of the Bark Extracts of Pterocarpus santalinus L. for the Treatment of Alzheimer’s Disease</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=K.%20Biswas">K. Biswas</a>, <a href="https://publications.waset.org/search?q=U.%20H.%20Armin"> U. H. Armin</a>, <a href="https://publications.waset.org/search?q=S.%20M.%20J.%20Prodhan"> S. M. J. Prodhan</a>, <a href="https://publications.waset.org/search?q=J.%20A.%20Prithul"> J. A. Prithul</a>, <a href="https://publications.waset.org/search?q=S.%20Sarker"> S. Sarker</a>, <a href="https://publications.waset.org/search?q=F.%20Afrin"> F. Afrin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Alzheimer’s disease (AD) (a progressive neurodegenerative disorder) is mostly predominant cause of dementia in the elderly. Prolonging the function of acetylcholine by inhibiting both acetylcholinesterase and butyrylcholinesterase is most effective treatment therapy of AD. Traditionally <em>Pterocarpus santalinus</em> L. is widely known for its medicinal use. In this study, <em>in vitro</em> acetylcholinesterase inhibitory activity was investigated and methanolic extract of the plant showed significant activity. To confirm this activity (<em>in vivo</em>), learning and memory enhancing effects were tested in mice. For the test, memory impairment was induced by scopolamine (cholinergic muscarinic receptor antagonist). Anti-amnesic effect of the extract was investigated by the passive avoidance task in mice. The study also includes brain acetylcholinesterase activity. Results proved that scopolamine induced cognitive dysfunction was significantly decreased by administration of the extract solution, in the passive avoidance task and inhibited brain acetylcholinesterase activity. These results suggest that bark extract of <em>Pterocarpus santalinus</em> can be better option for further studies on AD via their acetylcholinesterase inhibitory actions.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Pterocarpus%20santalinus" title="Pterocarpus santalinus">Pterocarpus santalinus</a>, <a href="https://publications.waset.org/search?q=cholinesterase%20inhibitor" title=" cholinesterase inhibitor"> cholinesterase inhibitor</a>, <a href="https://publications.waset.org/search?q=passive%20avoidance" title=" passive avoidance"> passive avoidance</a>, <a href="https://publications.waset.org/search?q=Alzheimer%E2%80%99s%20disease." title=" Alzheimer’s disease."> Alzheimer’s disease.</a> </p> <a href="https://publications.waset.org/10009808/in-vitro-and-in-vivo-assessment-of-cholinesterase-inhibitory-activity-of-the-bark-extracts-of-pterocarpus-santalinus-l-for-the-treatment-of-alzheimers-disease" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10009808/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10009808/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10009808/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10009808/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10009808/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10009808/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10009808/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10009808/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10009808/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10009808/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10009808.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">827</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Time and Frequency Domain Analysis of Heart Rate Variability and their Correlations in Diabetes Mellitus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=P.%20T.%20Ahamed%20Seyd">P. T. Ahamed Seyd</a>, <a href="https://publications.waset.org/search?q=V.%20I.%20Thajudin%20Ahamed"> V. I. Thajudin Ahamed</a>, <a href="https://publications.waset.org/search?q=Jeevamma%20Jacob"> Jeevamma Jacob</a>, <a href="https://publications.waset.org/search?q=Paul%20Joseph%20K"> Paul Joseph K</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetes mellitus (DM) is frequently characterized by autonomic nervous dysfunction. Analysis of heart rate variability (HRV) has become a popular noninvasive tool for assessing the activities of autonomic nervous system (ANS). In this paper, changes in ANS activity are quantified by means of frequency and time domain analysis of R-R interval variability. Electrocardiograms (ECG) of 16 patients suffering from DM and of 16 healthy volunteers were recorded. Frequency domain analysis of extracted normal to normal interval (NN interval) data indicates significant difference in very low frequency (VLF) power, low frequency (LF) power and high frequency (HF) power, between the DM patients and control group. Time domain measures, standard deviation of NN interval (SDNN), root mean square of successive NN interval differences (RMSSD), successive NN intervals differing more than 50 ms (NN50 Count), percentage value of NN50 count (pNN50), HRV triangular index and triangular interpolation of NN intervals (TINN) also show significant difference between the DM patients and control group. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Autonomic%20nervous%20system" title="Autonomic nervous system">Autonomic nervous system</a>, <a href="https://publications.waset.org/search?q=diabetes%20mellitus" title=" diabetes mellitus"> diabetes mellitus</a>, <a href="https://publications.waset.org/search?q=frequency%20domain%20and%20time%20domain%20analysis" title=" frequency domain and time domain analysis"> frequency domain and time domain analysis</a>, <a href="https://publications.waset.org/search?q=heart%20rate%20variability." title=" heart rate variability."> heart rate variability.</a> </p> <a href="https://publications.waset.org/3827/time-and-frequency-domain-analysis-of-heart-rate-variability-and-their-correlations-in-diabetes-mellitus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/3827/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/3827/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/3827/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/3827/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/3827/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/3827/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/3827/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/3827/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/3827/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/3827/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/3827.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">3112</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> ZBTB17 Gene rs10927875 Polymorphism in Slovak Patients with Dilated Cardiomyopathy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=I.%20Boro%C5%88ov%C3%A1">I. Boroňová</a>, <a href="https://publications.waset.org/search?q=J.%20Bernasovsk%C3%A1"> J. Bernasovská</a>, <a href="https://publications.waset.org/search?q=J.%20Kmec"> J. Kmec</a>, <a href="https://publications.waset.org/search?q=E.%20Petrej%C4%8D%C3%ADkov%C3%A1"> E. Petrejčíková</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Dilated cardiomyopathy (DCM) is a severe cardiovascular disorder characterized by progressive systolic dysfunction due to cardiac chamber dilatation and inefficient myocardial contractility often leading to chronic heart failure. Recently, a genome-wide association studies (GWASs) on DCM indicate that the ZBTB17 gene rs10927875 single nucleotide polymorphism is associated with DCM. The aim of the study was to identify the distribution of ZBTB17 gene rs10927875 polymorphism in 50 Slovak patients with DCM and 80 healthy control subjects using the Custom Taqman®SNP Genotyping assays. Risk factors detected at baseline in each group included age, sex, body mass index, smoking status, diabetes and blood pressure. The mean age of patients with DCM was 52.9±6.3 years; the mean age of individuals in control group was 50.3±8.9 years. The distribution of investigated genotypes of rs10927875 polymorphism within ZBTB17 gene in the cohort of Slovak patients with DCM was as follows: CC (38.8%), CT (55.1%), TT (6.1%), in controls: CC (43.8%), CT (51.2%), TT (5.0%). The risk allele T was more common among the patients with dilated cardiomyopathy than in normal controls (33.7% versus 30.6%). The differences in genotype or allele frequencies of ZBTB17 gene rs10927875 polymorphism were not statistically significant (p=0.6908; p=0.6098). The results of this study suggest that ZBTB17 gene rs10927875 polymorphism may be a risk factor for susceptibility to DCM in Slovak patients with DCM. Studies of numerous files and additional functional investigations are needed to fully understand the roles of genetic associations.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Dilated%20cardiomyopathy" title="Dilated cardiomyopathy">Dilated cardiomyopathy</a>, <a href="https://publications.waset.org/search?q=SNP%20polymorphism" title=" SNP polymorphism"> SNP polymorphism</a>, <a href="https://publications.waset.org/search?q=ZBTB17%20gene." title=" ZBTB17 gene."> ZBTB17 gene.</a> </p> <a href="https://publications.waset.org/9999352/zbtb17-gene-rs10927875-polymorphism-in-slovak-patients-with-dilated-cardiomyopathy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/9999352/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/9999352/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/9999352/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/9999352/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/9999352/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/9999352/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/9999352/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/9999352/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/9999352/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/9999352/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/9999352.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2141</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> Iterative Estimator-Based Nonlinear Backstepping Control of a Robotic Exoskeleton</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Brahmi%20Brahim">Brahmi Brahim</a>, <a href="https://publications.waset.org/search?q=Mohammad%20Habibur%20Rahman"> Mohammad Habibur Rahman</a>, <a href="https://publications.waset.org/search?q=Maarouf%20Saad"> Maarouf Saad</a>, <a href="https://publications.waset.org/search?q=Crist%C3%B3bal%20Ochoa%20Luna"> Cristóbal Ochoa Luna</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A repetitive training movement is an efficient method to improve the ability and movement performance of stroke survivors and help them to recover their lost motor function and acquire new skills. The ETS-MARSE is seven degrees of freedom (DOF) exoskeleton robot developed to be worn on the lateral side of the right upper-extremity to assist and rehabilitate the patients with upper-extremity dysfunction resulting from stroke. Practically, rehabilitation activities are repetitive tasks, which make the assistive/robotic systems to suffer from repetitive/periodic uncertainties and external perturbations induced by the high-order dynamic model (seven DOF) and interaction with human muscle which impact on the tracking performance and even on the stability of the exoskeleton. To ensure the robustness and the stability of the robot, a new nonlinear backstepping control was implemented with designed tests performed by healthy subjects. In order to limit and to reject the periodic/repetitive disturbances, an iterative estimator was integrated into the control of the system. The estimator does not need the precise dynamic model of the exoskeleton. Experimental results confirm the robustness and accuracy of the controller performance to deal with the external perturbation, and the effectiveness of the iterative estimator to reject the repetitive/periodic disturbances. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Backstepping%20control" title="Backstepping control">Backstepping control</a>, <a href="https://publications.waset.org/search?q=iterative%20control" title=" iterative control"> iterative control</a>, <a href="https://publications.waset.org/search?q=rehabilitation" title=" rehabilitation"> rehabilitation</a>, <a href="https://publications.waset.org/search?q=ETS-MARSE." title=" ETS-MARSE."> ETS-MARSE.</a> </p> <a href="https://publications.waset.org/10004974/iterative-estimator-based-nonlinear-backstepping-control-of-a-robotic-exoskeleton" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10004974/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10004974/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10004974/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10004974/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10004974/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10004974/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10004974/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10004974/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10004974/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10004974/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10004974.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1369</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Comparisons of Fine Motor Functions in Subjects with Parkinson’s Disease and Essential Tremor</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Nan-Ying%20Yu">Nan-Ying Yu</a>, <a href="https://publications.waset.org/search?q=Shao-Hsia%20Chang"> Shao-Hsia Chang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>This study explores the clinical features of neurodegenerative disease patients with tremor. We study the motor impairments in patients with Parkinson’s disease (PD) and essential tremor (ET). Since uncertainty exists on whether Parkinson's disease (PD) and essential tremor (ET) patients have similar degree of impairment during motor tasks, this study based on the self-developed computerized handwriting movement analysis to characterize motor functions of these two impairments. The recruited subjects were diagnosed and confirmed one of neurodegenerative diseases. They were undergone general clinical evaluations by physicians in the first year. We recruited 8 participants with PD and 10 with ET. Additional 12 participants without any neuromuscular dysfunction were recruited as control group. This study used fine motor control of penmanship on digital tablet for sensorimotor function tests. The movement speed in PD/ET group is found significant slower than subjects in normal control group. In movement intensity and speed, the result found subject with ET has similar clinical feature with PD subjects. The ET group shows smaller and slower movements than control group but not to the same extent as PD group. The results of this study contribute to the early screening and detection of diseases and the evaluation of disease progression.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Parkinson%E2%80%99s%20disease" title="Parkinson’s disease">Parkinson’s disease</a>, <a href="https://publications.waset.org/search?q=essential%20tremor" title=" essential tremor"> essential tremor</a>, <a href="https://publications.waset.org/search?q=motor%20function" title=" motor function"> motor function</a>, <a href="https://publications.waset.org/search?q=fine%20motor%20movement" title=" fine motor movement"> fine motor movement</a>, <a href="https://publications.waset.org/search?q=computerized%20handwriting%20evaluation." title=" computerized handwriting evaluation. "> computerized handwriting evaluation. </a> </p> <a href="https://publications.waset.org/17146/comparisons-of-fine-motor-functions-in-subjects-with-parkinsons-disease-and-essential-tremor" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/17146/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/17146/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/17146/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/17146/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/17146/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/17146/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/17146/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/17146/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/17146/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/17146/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/17146.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2278</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Efficacy of Biofeedback-Assisted Pelvic Floor Muscle Training on Postoperative Stress Urinary Incontinence</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Asmaa%20M.%20El-Bandrawy">Asmaa M. El-Bandrawy</a>, <a href="https://publications.waset.org/search?q=Afaf%20M.%20Botla"> Afaf M. Botla</a>, <a href="https://publications.waset.org/search?q=Ghada%20E.%20El-Refaye"> Ghada E. El-Refaye</a>, <a href="https://publications.waset.org/search?q=Hassan%20O.%20Ghareeb"> Hassan O. Ghareeb</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Background: Urinary incontinence is a common problem among adults. Its incidence increases with age and it is more frequent in women. Pelvic floor muscle training (PFMT) is the first-line therapy in the treatment of pelvic floor dysfunction (PFD) either alone or combined with biofeedback-assisted PFMT. The aim of the work: The purpose of this study is to evaluate the efficacy of biofeedback-assisted PFMT in postoperative stress urinary incontinence. Settings and Design: A single blind controlled trial design was. Methods and Material: This study was carried out in 30 volunteer patients diagnosed as severe degree of stress urinary incontinence and they were admitted to surgical treatment. They were divided randomly into two equal groups: (Group A) consisted of 15 patients who had been treated with post-operative biofeedback-assisted PFMT and home exercise program (Group B) consisted of 15 patients who had been treated with home exercise program only. Assessment of all patients in both groups (A) and (B) was carried out before and after the treatment program by measuring intra-vaginal pressure in addition to the visual analog scale. Results: At the end of the treatment program, there was a highly statistically significant difference between group (A) and group (B) in the intra-vaginal pressure and the visual analog scale favoring the group (A). Conclusion: biofeedback-assisted PFMT is an effective method for the symptomatic relief of post-operative female stress urinary incontinence.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Stress%20urinary%20incontinence" title="Stress urinary incontinence">Stress urinary incontinence</a>, <a href="https://publications.waset.org/search?q=pelvic%20floor%20muscles" title=" pelvic floor muscles"> pelvic floor muscles</a>, <a href="https://publications.waset.org/search?q=pelvic%20floor%20exercises" title=" pelvic floor exercises"> pelvic floor exercises</a>, <a href="https://publications.waset.org/search?q=biofeedback." title=" biofeedback."> biofeedback.</a> </p> <a href="https://publications.waset.org/10004668/efficacy-of-biofeedback-assisted-pelvic-floor-muscle-training-on-postoperative-stress-urinary-incontinence" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10004668/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10004668/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10004668/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10004668/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10004668/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10004668/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10004668/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10004668/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10004668/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10004668/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10004668.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1419</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Comparative in silico and in vitro Study of N-(1- Methyl-2-Oxo-2-N-Methyl Anilino-Ethyl) Benzene Sulfonamide and Its Analogues as an Anticancer Agent</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Pamita%20Awasthi">Pamita Awasthi</a>, <a href="https://publications.waset.org/search?q=Kirna"> Kirna</a>, <a href="https://publications.waset.org/search?q=Shilpa%20Dogra"> Shilpa Dogra</a>, <a href="https://publications.waset.org/search?q=Manu%20Vatsal"> Manu Vatsal</a>, <a href="https://publications.waset.org/search?q=Ritu%20Barthwal"> Ritu Barthwal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Doxorubicin, also known as Adriamycin, is an anthracycline class of drug used in cancer chemotherapy. It is used in the treatment of non-Hodgkin’s lymphoma, multiple myeloma, acute leukemia, breast cancer, lung cancer, endometrium cancer and ovary cancers. It functions via intercalating DNA and ultimately killing cancer cells. The major side effects of doxorubicin are hair loss, myelosuppression, nausea & vomiting, oesophagitis, diarrhea, heart damage and liver dysfunction. The minor modifications in the structure of compound exhibit large variation in the biological activity, has prompted us to carry out the synthesis of sulfonamide derivatives. Sulfonamide is an important feature with broad spectrum of biological activity such as antiviral, antifungal, diuretics, antiinflammatory, antibacterial and anticancer activities. Structure of the synthesized compound N-(1-methyl-2-oxo-2-N-methyl anilinoethyl) benzene sulfonamide confirmed by proton nuclear magnetic resonance (1H NMR),13C NMR, Mass and FTIR spectroscopic tools to assure the position of all protons and hence stereochemistry of the molecule. Further we have reported the binding potential of synthesized sulfonamide analogues in comparison to doxorubicin drug using Auto Dock 4.2 software. Computational binding energy (B.E.) and inhibitory constant (Ki) has been evaluated for the synthesized compound in comparison of doxorubicin against Poly (dA-dT).Poly (dA-dT) and Poly (dG-dC).Poly (dG-dC) sequences. The in vitro cytotoxic study against human breast cancer cell lines confirms the better anticancer activity of the synthesized compound over currently in use anticancer drug doxorubicin. The IC50 value of the synthesized compound is 7.12 μM whereas for doxorubicin is 7.2 μM.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Anticancer" title="Anticancer">Anticancer</a>, <a href="https://publications.waset.org/search?q=Auto%20Dock" title=" Auto Dock"> Auto Dock</a>, <a href="https://publications.waset.org/search?q=Doxorubicin" title=" Doxorubicin"> Doxorubicin</a>, <a href="https://publications.waset.org/search?q=Sulfonamide." title=" Sulfonamide."> Sulfonamide.</a> </p> <a href="https://publications.waset.org/10000776/comparative-in-silico-and-in-vitro-study-of-n-1-methyl-2-oxo-2-n-methyl-anilino-ethyl-benzene-sulfonamide-and-its-analogues-as-an-anticancer-agent" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10000776/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10000776/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10000776/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10000776/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10000776/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10000776/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10000776/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10000776/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10000776/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10000776/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10000776.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2342</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Microalbuminuria in Essential Hypertension</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Sharan%20Badiger">Sharan Badiger</a>, <a href="https://publications.waset.org/search?q=Prema%20T.%20Akkasaligar"> Prema T. Akkasaligar</a>, <a href="https://publications.waset.org/search?q=Sandeep%20HM"> Sandeep HM</a>, <a href="https://publications.waset.org/search?q=Biradar%20MS"> Biradar MS</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Essential hypertension (HTN) usually clusters with other cardiovascular risk factors such as age, overweight, diabetes, insulin resistance and dyslipidemia. The target organ damage (TOD) such as left ventricular hypertrophy, microalbuminuria (MA), acute coronary syndrome (ACS), stroke and cognitive dysfunction takes place early in course of hypertension. Though the prevalence of hypertension is high in India, the relationship between microalbuminuria and target organ damage in hypertension is not well studied. This study aim at detecting MA in essential hypertension and its relation to severity of HTN, duration of HTN, body mass index (BMI), age and TOD such as HTN retinopathy and acute coronary syndrome The present study was done in 100 patients of essential hypertension non diabetics admitted to B.L.D.E.University-s Sri B.M.Patil Medical College, Bijapur, from October 2008 to April 2011. The patients underwent detailed history and clinical examination. Early morning 5 ml of urine sample was collected & MA was estimated by immunoturbidometry method. The relationship of MA with the duration & severity of HTN, BMI, age, sex and TOD's like hypertensive retinopathy, ACS was assessed by univariate analysis. The prevalence of MA in this study was found to be 63 %. In that 42% were male & 21% were female. In this study a significant association between MA and the duration of hypertension (p = 0.036) & (OR =0.438). Longer the duration of hypertension, more possibility of microalbumin in urine. Also there was a significant association between severity of hypertension and MA (p=0.045) and (OR=0.093). MA was positive in 50 (79.4%) patients out of 63, whose blood pressure was >160/100 mm Hg. In this study a significant association between MA and the grades of hypertensive retinopathy (p =0.011) and acute coronary syndrome (p = 0.041) (OR =2.805). Gender and BMI did not pose high risk for MA in this study.The prevalence of MA in essential hypertension is high in this part of the community and MA will increase the risk of developing target organ damage.Early screening of patients with essential hypertension for MA and aggressive management of positive cases might reduce the burden of chronic kidney diseases and cardiovascular diseases in the community.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Acute%20coronary%20syndrome" title="Acute coronary syndrome">Acute coronary syndrome</a>, <a href="https://publications.waset.org/search?q=Essential%20hypertension" title=" Essential hypertension"> Essential hypertension</a>, <a href="https://publications.waset.org/search?q=Microalbuminuria" title=" Microalbuminuria"> Microalbuminuria</a>, <a href="https://publications.waset.org/search?q=Target%20organ%20damage" title=" Target organ damage"> Target organ damage</a> </p> <a href="https://publications.waset.org/15154/microalbuminuria-in-essential-hypertension" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/15154/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/15154/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/15154/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/15154/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/15154/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/15154/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/15154/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/15154/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/15154/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/15154/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/15154.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2390</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> In vitro and in vivo Anticholinesterase Activity of the Volatile Oil of the Aerial Parts of Ocimum basilicum L. and O. africanum Lour. Growing in Egypt</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=M.%20G.%20Tadros">M. G. Tadros</a>, <a href="https://publications.waset.org/search?q=S.%20M.%20Ezzat"> S. M. Ezzat</a>, <a href="https://publications.waset.org/search?q=M.%20M.%20Salama"> M. M. Salama</a>, <a href="https://publications.waset.org/search?q=M.%20A.%20Farag"> M. A. Farag</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p><span style="line-height: 20.8px;">In this study, the in vitro anticholinesterase activity of</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">the volatile oils of both O. basilicum and O. africanum was</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">investigated and both samples showed significant activity. The major</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">constituents of the two oils were isolated using several column</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">chromatographies. Linalool, 1,8-cineol and eugenol were isolated</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">from the volatile oil of O. basilicum and camphor was isolated from</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">the volatile oil of O. africanum. The anticholinesterase activities of</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">the isolated compounds were also evaluated where 1,8-cineol showed</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">the highest inhibitory activity followed by camphor. To confirm these</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">activities, learning and memory enhancing effects were tested in</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">mice. Memory impairment was induced by scopolamine, a</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">cholinergic muscarinic receptor antagonist. Anti-amnesic effects of</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">both volatile oils and their terpenoids were investigated by the</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">passive avoidance task in mice. We also examined their effects on</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">brain acetylcholinesterase activity. Results showed that scopolamineinduced</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">cognitive dysfunction was significantly attenuated by</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">administration of the volatile oils and their terpenoids, eugenol and</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">camphor, in the passive avoidance task and inhibited brain</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">acetylcholinesterase activity. These results suggest that O. basilicum</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">and O. africanum volatile oils can be good candidates for further</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">studies on Alzheimer’s disease via their acetylcholinesterase</span><br style="line-height: 20.8px;" /> <span style="line-height: 20.8px;">inhibitory actions.</span></p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Acetylcholinesterase" title="Acetylcholinesterase">Acetylcholinesterase</a>, <a href="https://publications.waset.org/search?q=Ocimum%20africanum" title=" Ocimum africanum"> Ocimum africanum</a>, <a href="https://publications.waset.org/search?q=Ocimum%20basilicum" title=" Ocimum basilicum"> Ocimum basilicum</a>, <a href="https://publications.waset.org/search?q=passive%20avoidance." title=" passive avoidance."> passive avoidance.</a> </p> <a href="https://publications.waset.org/9997670/in-vitro-and-in-vivo-anticholinesterase-activity-of-the-volatile-oil-of-the-aerial-parts-of-ocimum-basilicum-l-and-o-africanum-lour-growing-in-egypt" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/9997670/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/9997670/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/9997670/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/9997670/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/9997670/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/9997670/json" target="_blank" rel="nofollow" class="btn btn-primary 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