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Petković</title> <meta name="description" content="Search results for: Marijana Petković"> <meta name="keywords" content="Marijana Petković"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Marijana Petković"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 9</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Marijana Petković</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> The Role of Female Population as a Consumer in Modern Marketing Strategy and Management</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jana%20Aleksi%C4%87">Jana Aleksić</a>, <a href="https://publications.waset.org/abstracts/search?q=Marijana%20Petkovi%C4%87"> Marijana Petković</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Female population has an increasing role when it comes to purchase. Consequently, the female population has a greater role in modern marketing. Although it is thought that women buy more than men, marketing strategy was not directed specifically towards women. The thing that has changed regarding women’s role in modern marketing is the fact that the female population has a leading position when it comes to decision making in various fields and various sectors, which was not the case in the past. Marketing should be directed towards women but it should be done in the right way. Compared to men, women buy in a different way, and they look for more various advantages in the product itself, than men do. This paper aims to show the importance of the female role in the modern marketing and management and to redirect marketing in some way towards female population through new marketing strategies and management systems. Hypothesis is that women have an important role in marketing, and marketing strategy of modern society could and should be based on and directed towards female population and their tastes when it comes to purchasing. It is necessary and desirable to apply marketing strategy with a special strategy that has an emphasis on women and their purchase or in a word to apply WS- woman strategy. This research was carried out as a random sample research, where were obtained 212 valid surveys whose results serve as a basis for drawing conclusions about the research as well as to verify the formulated hypotheses. The research was carried out during 2011 and 2012. The study has shown a significant role of the female population in the marketing process. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=marketing" title="marketing">marketing</a>, <a href="https://publications.waset.org/abstracts/search?q=management" title=" management"> management</a>, <a href="https://publications.waset.org/abstracts/search?q=female" title=" female"> female</a>, <a href="https://publications.waset.org/abstracts/search?q=purchase" title=" purchase"> purchase</a>, <a href="https://publications.waset.org/abstracts/search?q=strategy" title=" strategy"> strategy</a> </p> <a href="https://publications.waset.org/abstracts/47410/the-role-of-female-population-as-a-consumer-in-modern-marketing-strategy-and-management" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/47410.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">448</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> The Continuously Supported Infinity Rail Subjected to a Moving Complex Bogie System </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vladimir%20Stojanovi%C4%87">Vladimir Stojanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Marko%20D.%20Petkovi%C4%87"> Marko D. Petković</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The vibration of a complex bogie system that moves on along the high order shear deformable beam on a viscoelastic foundation is studied. The complex bogie system has been modeled by elastically connected rigid bars on an identical supports. Elastic coupling between bars is introduced to simulate rigidly or flexibly (transversal or/and rotational) connection. Identical supports are modeled as a system of attached spring and dashpot to the bar on one side and interact with the beam through the concentrated mass on the other side. It is assumed that the masses and the beam are always in contact. New analytically determined critical velocity of the system is presented. It is analyzed the case when the complex bogie system exceeds the minimum phase velocity of waves in the beam when the vibration of the system may become unstable. Effect of an elastic coupling between bars on the stability of the system has been analyzed. The instability regions are found for the complex bogie system by applying the principle of the argument and D-decomposition method. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Reddy-Bickford%20beam" title="Reddy-Bickford beam">Reddy-Bickford beam</a>, <a href="https://publications.waset.org/abstracts/search?q=D-decomposition%20method" title=" D-decomposition method"> D-decomposition method</a>, <a href="https://publications.waset.org/abstracts/search?q=principle%20of%20argument" title=" principle of argument"> principle of argument</a>, <a href="https://publications.waset.org/abstracts/search?q=critical%20velocity" title=" critical velocity"> critical velocity</a> </p> <a href="https://publications.waset.org/abstracts/60948/the-continuously-supported-infinity-rail-subjected-to-a-moving-complex-bogie-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/60948.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">306</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Generating Insights from Data Using a Hybrid Approach</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Allmin%20Susaiyah">Allmin Susaiyah</a>, <a href="https://publications.waset.org/abstracts/search?q=Aki%20H%C3%A4rm%C3%A4"> Aki Härmä</a>, <a href="https://publications.waset.org/abstracts/search?q=Milan%20Petkovi%C4%87"> Milan Petković</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Automatic generation of insights from data using insight mining systems (IMS) is useful in many applications, such as personal health tracking, patient monitoring, and business process management. Existing IMS face challenges in controlling insight extraction, scaling to large databases, and generalising to unseen domains. In this work, we propose a hybrid approach consisting of rule-based and neural components for generating insights from data while overcoming the aforementioned challenges. Firstly, a rule-based data 2CNL component is used to extract statistically significant insights from data and represent them in a controlled natural language (CNL). Secondly, a BERTSum-based CNL2NL component is used to convert these CNLs into natural language texts. We improve the model using task-specific and domain-specific fine-tuning. Our approach has been evaluated using statistical techniques and standard evaluation metrics. We overcame the aforementioned challenges and observed significant improvement with domain-specific fine-tuning. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=data%20mining" title="data mining">data mining</a>, <a href="https://publications.waset.org/abstracts/search?q=insight%20mining" title=" insight mining"> insight mining</a>, <a href="https://publications.waset.org/abstracts/search?q=natural%20language%20generation" title=" natural language generation"> natural language generation</a>, <a href="https://publications.waset.org/abstracts/search?q=pre-trained%20language%20models" title=" pre-trained language models"> pre-trained language models</a> </p> <a href="https://publications.waset.org/abstracts/159536/generating-insights-from-data-using-a-hybrid-approach" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/159536.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">119</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Tourism Competitiveness Survey Analysis of Serbian Ski Resorts</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marijana%20Panti%C4%87">Marijana Pantić</a>, <a href="https://publications.waset.org/abstracts/search?q=Sa%C5%A1a%20Miliji%C4%87"> Saša Milijić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In Serbia as a continental country, the tourism industry relies on city-break, spa and mountain tourism, where ski resorts have primacy during the winter season. Even though the number of tourists has recently increased, the share of domestic tourists remained predominant. It is also noticed that tourists from Serbia eagerly travel abroad, which was so far researched in the context of summer holidays but not in the framework of ski resorts. Therefore, this paper examines the competitiveness of ski resorts in Serbia from the perspective of domestic tourists. A survey was used as a data collection method, covering various competitiveness dimensions. The aim is to recognize the main motives of consumers when choosing a ski resort in Serbia or abroad. The results showed that the choices of Serbian tourists are predominantly shaped by the cost of an offer – of accommodation above all others. They are attentive by estimating the value for money, which is the most common reason to choose a ski resort abroad over a domestic one. The crowd at ski resorts and ski runs appears to be a result of unbalanced accommodation capacities on the one hand and ski infrastructure on the other, which is currently the most notable competitiveness drawback of ski resorts in Serbia. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mountain%20tourism" title="mountain tourism">mountain tourism</a>, <a href="https://publications.waset.org/abstracts/search?q=Serbia" title=" Serbia"> Serbia</a>, <a href="https://publications.waset.org/abstracts/search?q=ski%20resorts" title=" ski resorts"> ski resorts</a>, <a href="https://publications.waset.org/abstracts/search?q=tourism%20competitiveness" title=" tourism competitiveness"> tourism competitiveness</a> </p> <a href="https://publications.waset.org/abstracts/128885/tourism-competitiveness-survey-analysis-of-serbian-ski-resorts" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/128885.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">135</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Quantification of the Variables of the Information Model for the Use of School Terminology from 1884 to 2014 in Dalmatia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vinko%20Vidu%C4%8Di%C4%87">Vinko Vidučić</a>, <a href="https://publications.waset.org/abstracts/search?q=Tanja%20Bre%C5%A1an%20An%C4%8Di%C4%87"> Tanja Brešan Ančić</a>, <a href="https://publications.waset.org/abstracts/search?q=Marijana%20Tomeli%C4%87%20%C4%86urlin"> Marijana Tomelić Ćurlin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Prior to quantifying the variables of the information model for using school terminology in Croatia's region of Dalmatia from 1884 to 2014, the most relevant model variables had to be determined: historical circumstances, standard of living, education system, linguistic situation, and media. The research findings show that there was no significant transfer of the 1884 school terms into 1949 usage; likewise, the 1949 school terms were not widely used in 2014. On the other hand, the research revealed that the meaning of school terms changed over the decades. The quantification of the variables will serve as the groundwork for creating an information model for using school terminology in Dalmatia from 1884 to 2014 and for defining direct growth rates in further research. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=education%20system" title="education system">education system</a>, <a href="https://publications.waset.org/abstracts/search?q=historical%20circumstances" title=" historical circumstances"> historical circumstances</a>, <a href="https://publications.waset.org/abstracts/search?q=linguistic%20situation" title=" linguistic situation"> linguistic situation</a>, <a href="https://publications.waset.org/abstracts/search?q=media" title=" media"> media</a>, <a href="https://publications.waset.org/abstracts/search?q=school%20terminology" title=" school terminology"> school terminology</a>, <a href="https://publications.waset.org/abstracts/search?q=standard%20of%20living" title=" standard of living"> standard of living</a> </p> <a href="https://publications.waset.org/abstracts/23020/quantification-of-the-variables-of-the-information-model-for-the-use-of-school-terminology-from-1884-to-2014-in-dalmatia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23020.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">215</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> The Photocatalytic Degradation of Acid Blue 25 Dye by Polypyrrole/Titanium Dioxide and Polypyrrole/Zinc Oxide Composites</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ljerka%20Kratofil%20Krehula">Ljerka Kratofil Krehula</a>, <a href="https://publications.waset.org/abstracts/search?q=Martina%20Perlog"> Martina Perlog</a>, <a href="https://publications.waset.org/abstracts/search?q=Jasmina%20Stjepanovi%C4%87"> Jasmina Stjepanović</a>, <a href="https://publications.waset.org/abstracts/search?q=Vanja%20Gilja"> Vanja Gilja</a>, <a href="https://publications.waset.org/abstracts/search?q=Marijana%20Kralji%C4%87%20Rokovi%C4%87"> Marijana Kraljić Roković</a>, <a href="https://publications.waset.org/abstracts/search?q=Zlata%20Hrnjak-Murgi%C4%87"> Zlata Hrnjak-Murgić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The composite preparation of titanium dioxide and zinc oxide photocatalysts with the conductive polymers gives the opportunity to carry out the catalysis reactions not only under UV light but also under visible light. Such processes may efficiently use sunlight in degradation of different organic pollutants and present new design for wastewater treatment. The paper presents the preparation procedure, material characteristics and photocatalytic efficiency of polypyrrole/titanium dioxide and polypyrrole/zinc oxide composites (PPy/TiO2 and PPy/ZnO). The obtained composite samples were characterized by Fourier transform infrared spectroscopy (FTIR), UV-Vis spectroscopy and thermogravimetric analysis (TGA). The photocatalytic efficiency of the samples was determined following the decomposition of Acid Blue 25 dye (AB 25) under UV and visible light by UV/Vis spectroscopy. The efficiency of degradation is determined by total organic carbon content (TOC) after photocatalysis processes. The results show enhanced photocatalytic efficiency of the samples under visible light, so the prepared composite samples are recognized as efficient catalysts in degradation process of AB 25 dye. It can be concluded that the preparation of TiO2 or ZnO composites with PPy can serve as a very efficient method for the improvement of TiO2 and ZnO photocatalytic performance under visible light. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=composite" title="composite">composite</a>, <a href="https://publications.waset.org/abstracts/search?q=photocatalysis" title=" photocatalysis"> photocatalysis</a>, <a href="https://publications.waset.org/abstracts/search?q=polypyrrole" title=" polypyrrole"> polypyrrole</a>, <a href="https://publications.waset.org/abstracts/search?q=titanium%20dioxide" title=" titanium dioxide"> titanium dioxide</a>, <a href="https://publications.waset.org/abstracts/search?q=zinc%20oxide" title=" zinc oxide"> zinc oxide</a> </p> <a href="https://publications.waset.org/abstracts/79349/the-photocatalytic-degradation-of-acid-blue-25-dye-by-polypyrroletitanium-dioxide-and-polypyrrolezinc-oxide-composites" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/79349.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">486</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Authenticity of Lipid and Soluble Sugar Profiles of Various Oat Cultivars (Avena sativa)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marijana%20M.%20A%C4%8Danski">Marijana M. Ačanski</a>, <a href="https://publications.waset.org/abstracts/search?q=Kristian%20A.%20Pastor"> Kristian A. Pastor</a>, <a href="https://publications.waset.org/abstracts/search?q=Djura%20N.%20Vuji%C4%87"> Djura N. Vujić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The identification of lipid and soluble sugar components in flour samples of different cultivars belonging to common oat species (Avena sativa L.) was performed: spring oat, winter oat and hulless oat. Fatty acids were extracted from flour samples with n-hexane, and derivatized into volatile methyl esters, using TMSH (trimethylsulfonium hydroxide in methanol). Soluble sugars were then extracted from defatted and dried samples of oat flour with 96% ethanol, and further derivatized into corresponding TMS-oximes, using hydroxylamine hydrochloride solution and BSTFA (N,O-bis-(trimethylsilyl)-trifluoroacetamide). The hexane and ethanol extracts of each oat cultivar were analyzed using GC-MS system. Lipid and simple sugar compositions are very similar in all samples of investigated cultivars. Chemometric tool was applied to numeric values of automatically integrated surface areas of detected lipid and simple sugar components in their corresponding derivatized forms. Hierarchical cluster analysis shows a very high similarity between the investigated flour samples of oat cultivars, according to the fatty acid content (0.9955). Moderate similarity was observed according to the content of soluble sugars (0.50). These preliminary results support the idea of establishing methods for oat flour authentication, and provide the means for distinguishing oat flour samples, regardless of the variety, from flour samples made of other cereal species, just by lipid and simple sugar profile analysis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=oat%20cultivars" title="oat cultivars">oat cultivars</a>, <a href="https://publications.waset.org/abstracts/search?q=lipid%20composition" title=" lipid composition"> lipid composition</a>, <a href="https://publications.waset.org/abstracts/search?q=soluble%20sugar%20composition" title=" soluble sugar composition"> soluble sugar composition</a>, <a href="https://publications.waset.org/abstracts/search?q=GC-MS" title=" GC-MS"> GC-MS</a>, <a href="https://publications.waset.org/abstracts/search?q=chemometrics" title=" chemometrics"> chemometrics</a>, <a href="https://publications.waset.org/abstracts/search?q=authentication" title=" authentication"> authentication</a> </p> <a href="https://publications.waset.org/abstracts/41530/authenticity-of-lipid-and-soluble-sugar-profiles-of-various-oat-cultivars-avena-sativa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41530.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">295</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Banking Union: A New Step towards Completing the Economic and Monetary Union</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marijana%20Ivanov">Marijana Ivanov</a>, <a href="https://publications.waset.org/abstracts/search?q=Roman%20%C5%A0ubi%C4%87"> Roman Šubić</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The single rulebook together with the Single Supervisory Mechanism and the Single Resolution Mechanism - as two main pillars of the banking union, represent important steps towards completing the Economic and Monetary Union. It should provide a consistent application of common rules and administrative standards for supervision, recovery and resolution of banks – with the final aim that a former practice of the bail-out is replaced with the bail-in system through which bank failures will be resolved by their own funds, i.e. with minimal costs for taxpayers and real economy. It has to reduce the financial fragmentation recorded in the years of crisis as the result of divergent behaviors in risk premium, lending activities, and interest rates between the core and the periphery. In addition, it should strengthen the effectiveness of monetary transmission channels, in particular the credit channels and overflows of liquidity on the single interbank money market. However, contrary to all the positive expectations related to the future functioning of the banking union, low and unbalanced economic growth rates remain a challenge for the maintenance of financial stability in the euro area, and this problem cannot be resolved just by a single supervision. In many countries bank assets exceed their GDP by several times, and large banks are still a matter of concern because of their systemic importance for individual countries and the euro zone as a whole. The creation of the SSM and the SRM should increase transparency of the banking system in the euro area and restore confidence that have been disturbed during the depression. It would provide a new opportunity to strengthen economic and financial systems in the peripheral countries. On the other hand, there is a potential threat that future focus of the ECB, resolution mechanism and other relevant institutions will be extremely oriented to the large and significant banks (whereby one half of them operate in the core and most important euro area countries), while it is questionable to what extent the common resolution funds will be used for rescue of less important institutions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=banking%20union" title="banking union">banking union</a>, <a href="https://publications.waset.org/abstracts/search?q=financial%20integration" title=" financial integration"> financial integration</a>, <a href="https://publications.waset.org/abstracts/search?q=single%20supervision%20mechanism%20%28SSM%29" title=" single supervision mechanism (SSM)"> single supervision mechanism (SSM)</a> </p> <a href="https://publications.waset.org/abstracts/22823/banking-union-a-new-step-towards-completing-the-economic-and-monetary-union" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22823.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">470</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Genome-Wide Analysis Identifies Locus Associated with Parathyroid Hormone Levels</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Antonela%20Matana">Antonela Matana</a>, <a href="https://publications.waset.org/abstracts/search?q=Dubravka%20Brdar"> Dubravka Brdar</a>, <a href="https://publications.waset.org/abstracts/search?q=Vesela%20Torlak"> Vesela Torlak</a>, <a href="https://publications.waset.org/abstracts/search?q=Marijana%20Popovic"> Marijana Popovic</a>, <a href="https://publications.waset.org/abstracts/search?q=Ivana%20%20Gunjaca"> Ivana Gunjaca</a>, <a href="https://publications.waset.org/abstracts/search?q=Ozren%20Polasek"> Ozren Polasek</a>, <a href="https://publications.waset.org/abstracts/search?q=Vesna%20Boraska%20Perica"> Vesna Boraska Perica</a>, <a href="https://publications.waset.org/abstracts/search?q=Maja%20Barbalic"> Maja Barbalic</a>, <a href="https://publications.waset.org/abstracts/search?q=Ante%20Punda"> Ante Punda</a>, <a href="https://publications.waset.org/abstracts/search?q=Caroline%20Hayward"> Caroline Hayward</a>, <a href="https://publications.waset.org/abstracts/search?q=Tatijana%20Zemunik"> Tatijana Zemunik</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Parathyroid hormone (PTH) plays a critical role in the regulation of bone mineral metabolism and calcium homeostasis. Higher PTH levels are associated with heart failure, hypertension, coronary artery disease, cardiovascular mortality and poorer bone health. A twin study estimated that 60% of the variation in PTH concentrations is genetically determined. Only one GWAS of PTH concentration has been reported to date. Identified loci explained 4.5% of the variance in circulating PTH, suggesting that additional genetic variants remain undiscovered. Therefore, the aim of this study was to identify novel genetic variants associated with PTH levels in a general population. We have performed a GWAS meta-analysis on 2596 individuals originating from three Croatian cohorts: City of Split and the Islands of Korčula and Vis, within a large-scale project of “10,001 Dalmatians”. A total of 7 411 206 variants, imputed using the 1000 Genomes reference panel, with minor allele frequency ≥ 1% and Rsq ≥ 0.5 were analyzed for the association. GWAS within each data set was performed under an additive model, controlling for age, gender and relatedness. Meta-analysis was conducted using the inverse-variance fixed-effects method. Furthermore, to identify sex-specific effects, we have conducted GWAS meta-analyses analyzing males and females separately. In addition, we have performed biological pathway analysis. Four SNPs, representing one locus, reached genome-wide significance. The most significant SNP was rs11099476 on chromosome 4 (P=1.15x10-8), which explained 1.14 % of the variance in PTH. The SNP is located near the protein-coding gene RASGEF1B. Additionally, we detected suggestive association with SNPs, rs77178854 located on chromosome 2 in the DPP10 gene (P=2.46x10-7) and rs481121 located on chromosome 1 (P=3.58x10-7) near the GRIK1 gene. One of the top hits detected in the main meta-analysis, intron variant rs77178854 located within DPP10 gene, reached genome-wide significance in females (P=2.21x10-9). No single locus was identified in the meta-analysis in males. Fifteen biological pathways were functionally enriched at a P<0.01, including muscle contraction, ion homeostasis and cardiac conduction as the most significant pathways. RASGEF1B is the guanine nucleotide exchange factor, known to be associated with height, bone density, and hip. DPP10 encodes a membrane protein that is a member of the serine proteases family, which binds specific voltage-gated potassium channels and alters their expression and biophysical properties. In conclusion, we identified 2 novel loci associated with PTH levels in a general population, providing us with further insights into the genetics of this complex trait. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=general%20population" title="general population">general population</a>, <a href="https://publications.waset.org/abstracts/search?q=genome-wide%20association%20analysis" title=" genome-wide association analysis"> genome-wide association analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=parathyroid%20hormone" title=" parathyroid hormone"> parathyroid hormone</a>, <a href="https://publications.waset.org/abstracts/search?q=single%20nucleotide%20polymorphisms." title=" single nucleotide polymorphisms."> single nucleotide polymorphisms.</a> </p> <a href="https://publications.waset.org/abstracts/75782/genome-wide-analysis-identifies-locus-associated-with-parathyroid-hormone-levels" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75782.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">225</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> 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