DNA Science - Geneticist Ricki Lewis blogs from the cutting edge of genomics, including genetic testing, stem cells, gene therapy and more.

<!doctype html> <html lang="en-US"> <head> <meta charset="utf-8"> <meta http-equiv="x-ua-compatible" content="ie=edge"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <script> const tracking = null; </script> <meta name='robots' content='index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1' />  <title>DNA Science - Geneticist Ricki Lewis blogs from the cutting edge of genomics, including genetic testing, stem cells, gene therapy and more.</title> <meta name="description" content="Geneticist Ricki Lewis blogs from the cutting edge of genomics, including genetic testing, stem cells, gene therapy and more." /> <link rel="canonical" href="https://dnascience.plos.org/" /> <link rel="next" href="https://dnascience.plos.org/page/2/" /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="website" /> <meta property="og:title" content="DNA Science" /> <meta property="og:description" content="Geneticist Ricki Lewis blogs from the cutting edge of genomics, including genetic testing, stem cells, gene therapy and more." /> <meta property="og:url" content="https://dnascience.plos.org/" /> <meta property="og:site_name" content="DNA Science" /> <meta name="twitter:card" content="summary_large_image" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"CollectionPage","@id":"https://dnascience.plos.org/","url":"https://dnascience.plos.org/","name":"DNA Science - Geneticist Ricki Lewis blogs from the cutting edge of genomics, including genetic testing, stem cells, gene therapy and more.","isPartOf":{"@id":"https://dnascience.plos.org/#website"},"description":"Geneticist Ricki Lewis blogs from the cutting edge of genomics, including genetic testing, stem cells, gene therapy and more.","breadcrumb":{"@id":"https://dnascience.plos.org/#breadcrumb"},"inLanguage":"en-US"},{"@type":"BreadcrumbList","@id":"https://dnascience.plos.org/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home"}]},{"@type":"WebSite","@id":"https://dnascience.plos.org/#website","url":"https://dnascience.plos.org/","name":"DNA Science","description":"Geneticist Ricki Lewis blogs from the cutting edge of genomics, including genetic testing, stem cells, gene therapy and more.","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://dnascience.plos.org/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}</script>  <link rel='dns-prefetch' href='//dnascience.plos.org' /> <script type="text/javascript"> /* <![CDATA[ */ window._wpemojiSettings = {"baseUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/72x72\/","ext":".png","svgUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/svg\/","svgExt":".svg","source":{"concatemoji":"https:\/\/dnascience.plos.org\/wp-includes\/js\/wp-emoji-release.min.js?ver=6.6.2"}}; /*! This file is auto-generated */ !function(i,n){var o,s,e;function c(e){try{var t={supportTests:e,timestamp:(new Date).valueOf()};sessionStorage.setItem(o,JSON.stringify(t))}catch(e){}}function p(e,t,n){e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(t,0,0);var t=new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data),r=(e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(n,0,0),new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data));return t.every(function(e,t){return e===r[t]})}function u(e,t,n){switch(t){case"flag":return n(e,"\ud83c\udff3\ufe0f\u200d\u26a7\ufe0f","\ud83c\udff3\ufe0f\u200b\u26a7\ufe0f")?!1:!n(e,"\ud83c\uddfa\ud83c\uddf3","\ud83c\uddfa\u200b\ud83c\uddf3")&&!n(e,"\ud83c\udff4\udb40\udc67\udb40\udc62\udb40\udc65\udb40\udc6e\udb40\udc67\udb40\udc7f","\ud83c\udff4\u200b\udb40\udc67\u200b\udb40\udc62\u200b\udb40\udc65\u200b\udb40\udc6e\u200b\udb40\udc67\u200b\udb40\udc7f");case"emoji":return!n(e,"\ud83d\udc26\u200d\u2b1b","\ud83d\udc26\u200b\u2b1b")}return!1}function f(e,t,n){var r="undefined"!=typeof WorkerGlobalScope&&self instanceof WorkerGlobalScope?new OffscreenCanvas(300,150):i.createElement("canvas"),a=r.getContext("2d",{willReadFrequently:!0}),o=(a.textBaseline="top",a.font="600 32px Arial",{});return e.forEach(function(e){o[e]=t(a,e,n)}),o}function t(e){var t=i.createElement("script");t.src=e,t.defer=!0,i.head.appendChild(t)}"undefined"!=typeof Promise&&(o="wpEmojiSettingsSupports",s=["flag","emoji"],n.supports={everything:!0,everythingExceptFlag:!0},e=new Promise(function(e){i.addEventListener("DOMContentLoaded",e,{once:!0})}),new Promise(function(t){var n=function(){try{var e=JSON.parse(sessionStorage.getItem(o));if("object"==typeof e&&"number"==typeof e.timestamp&&(new Date).valueOf()<e.timestamp+604800&&"object"==typeof e.supportTests)return e.supportTests}catch(e){}return null}();if(!n){if("undefined"!=typeof Worker&&"undefined"!=typeof OffscreenCanvas&&"undefined"!=typeof URL&&URL.createObjectURL&&"undefined"!=typeof Blob)try{var e="postMessage("+f.toString()+"("+[JSON.stringify(s),u.toString(),p.toString()].join(",")+"));",r=new Blob([e],{type:"text/javascript"}),a=new Worker(URL.createObjectURL(r),{name:"wpTestEmojiSupports"});return void(a.onmessage=function(e){c(n=e.data),a.terminate(),t(n)})}catch(e){}c(n=f(s,u,p))}t(n)}).then(function(e){for(var t in e)n.supports[t]=e[t],n.supports.everything=n.supports.everything&&n.supports[t],"flag"!==t&&(n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&n.supports[t]);n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&!n.supports.flag,n.DOMReady=!1,n.readyCallback=function(){n.DOMReady=!0}}).then(function(){return e}).then(function(){var e;n.supports.everything||(n.readyCallback(),(e=n.source||{}).concatemoji?t(e.concatemoji):e.wpemoji&&e.twemoji&&(t(e.twemoji),t(e.wpemoji)))}))}((window,document),window._wpemojiSettings); /* ]]> */ </script> <style id='wp-emoji-styles-inline-css' type='text/css'> img.wp-smiley, img.emoji { display: inline !important; border: none !important; box-shadow: none !important; height: 1em !important; width: 1em !important; margin: 0 0.07em !important; vertical-align: -0.1em !important; background: none !important; padding: 0 !important; } </style> <link rel='stylesheet' id='wp-block-library-css' href='https://dnascience.plos.org/wp-includes/css/dist/block-library/style.min.css?ver=6.6.2' type='text/css' media='all' /> <style id='safe-svg-svg-icon-style-inline-css' type='text/css'> .safe-svg-cover{text-align:center}.safe-svg-cover .safe-svg-inside{display:inline-block;max-width:100%}.safe-svg-cover svg{height:100%;max-height:100%;max-width:100%;width:100%} </style> <style id='co-authors-plus-coauthors-style-inline-css' type='text/css'> .wp-block-co-authors-plus-coauthors.is-layout-flow [class*=wp-block-co-authors-plus]{display:inline} </style> <style id='co-authors-plus-avatar-style-inline-css' type='text/css'> .wp-block-co-authors-plus-avatar :where(img){height:auto;max-width:100%;vertical-align:bottom}.wp-block-co-authors-plus-coauthors.is-layout-flow .wp-block-co-authors-plus-avatar :where(img){vertical-align:middle}.wp-block-co-authors-plus-avatar:is(.alignleft,.alignright){display:table}.wp-block-co-authors-plus-avatar.aligncenter{display:table;margin-inline:auto} </style> <style id='co-authors-plus-image-style-inline-css' type='text/css'> .wp-block-co-authors-plus-image{margin-bottom:0}.wp-block-co-authors-plus-image :where(img){height:auto;max-width:100%;vertical-align:bottom}.wp-block-co-authors-plus-coauthors.is-layout-flow .wp-block-co-authors-plus-image :where(img){vertical-align:middle}.wp-block-co-authors-plus-image:is(.alignfull,.alignwide) :where(img){width:100%}.wp-block-co-authors-plus-image:is(.alignleft,.alignright){display:table}.wp-block-co-authors-plus-image.aligncenter{display:table;margin-inline:auto} </style> <style id='global-styles-inline-css' type='text/css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: 20px;--wp--preset--font-size--large: 36px;--wp--preset--font-size--x-large: 42px;--wp--preset--spacing--20: 0.44rem;--wp--preset--spacing--30: 0.67rem;--wp--preset--spacing--40: 1rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2.25rem;--wp--preset--spacing--70: 3.38rem;--wp--preset--spacing--80: 5.06rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);}:where(body) { margin: 0; }.wp-site-blocks > .alignleft { float: left; margin-right: 2em; }.wp-site-blocks > .alignright { float: right; margin-left: 2em; }.wp-site-blocks > .aligncenter { justify-content: center; margin-left: auto; margin-right: auto; }:where(.is-layout-flex){gap: 0.5em;}:where(.is-layout-grid){gap: 0.5em;}.is-layout-flow > .alignleft{float: left;margin-inline-start: 0;margin-inline-end: 2em;}.is-layout-flow > .alignright{float: right;margin-inline-start: 2em;margin-inline-end: 0;}.is-layout-flow > .aligncenter{margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > .alignleft{float: left;margin-inline-start: 0;margin-inline-end: 2em;}.is-layout-constrained > .alignright{float: right;margin-inline-start: 2em;margin-inline-end: 0;}.is-layout-constrained > .aligncenter{margin-left: auto !important;margin-right: auto !important;}.is-layout-constrained > :where(:not(.alignleft):not(.alignright):not(.alignfull)){margin-left: auto !important;margin-right: auto !important;}body .is-layout-flex{display: flex;}.is-layout-flex{flex-wrap: wrap;align-items: center;}.is-layout-flex > :is(*, div){margin: 0;}body .is-layout-grid{display: grid;}.is-layout-grid > :is(*, div){margin: 0;}body{padding-top: 0px;padding-right: 0px;padding-bottom: 0px;padding-left: 0px;}a:where(:not(.wp-element-button)){text-decoration: underline;}:root :where(.wp-element-button, .wp-block-button__link){background-color: #32373c;border-width: 0;color: #fff;font-family: inherit;font-size: inherit;line-height: inherit;padding: calc(0.667em + 2px) calc(1.333em + 2px);text-decoration: none;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;} :where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;} :where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;} :root :where(.wp-block-pullquote){font-size: 1.5em;line-height: 1.6;} </style> <link rel='stylesheet' id='prefix-style-css' href='https://dnascience.plos.org/wp-content/plugins/orcid-master/assets/orcid.css?ver=6.6.2' type='text/css' media='all' /> <link rel='stylesheet' id='sage/main.css-css' href='https://dnascience.plos.org/wp-content/themes/plos/dist/styles/main_2eafddd7.css?ver=6.6.2' type='text/css' media='all' /> <script type="text/javascript" src="https://dnascience.plos.org/wp-content/themes/plos/resources/lib/scripts/jquery-3.5.1.min.js?ver=3.5.1" id="jquery-core-js"></script> <script type="text/javascript" src="https://dnascience.plos.org/wp-includes/js/jquery/jquery-migrate.min.js?ver=3.4.1" id="jquery-migrate-js"></script> <script type="text/javascript" src="https://dnascience.plos.org/wp-content/plugins/orcid-master/assets/orcid.js?ver=6.6.2" id="orcid-javascript-js"></script> <link rel="https://api.w.org/" href="https://dnascience.plos.org/wp-json/" /><link rel="EditURI" type="application/rsd+xml" title="RSD" href="https://dnascience.plos.org/xmlrpc.php?rsd" /> <meta name="generator" content="WordPress 6.6.2" /> <style type="text/css">.recentcomments a{display:inline !important;padding:0 !important;margin:0 !important;}</style> <link href="https://fonts.googleapis.com/css?family=Merriweather:400,400i,900,900i|Roboto:400,400i,600,600i&display=swap" rel="stylesheet"> <link rel="apple-touch-icon" sizes="180x180" href="https://plos.org/wp-content/themes/plos/favicon/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="https://plos.org/wp-content/themes/plos/favicon/favicon-32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="https://plos.org/wp-content/themes/plos/favicon/favicon-16x16.png"> <link rel="manifest" href="https://plos.org/wp-content/themes/plos/favicon/site.webmanifest"> <link rel="mask-icon" href="https://plos.org/wp-content/themes/plos/favicon/safari-pinned-tab.svg" color="#5bbad5"> <link rel="shortcut icon" href="https://plos.org/wp-content/themes/plos/favicon/favicon.ico"> <meta name="msapplication-TileColor" content="#00aba9"> <meta name="msapplication-config" content="https://plos.org/wp-content/themes/plos/favicon/browserconfig.xml"> <meta name="theme-color" content="#ffffff"> <style type="text/css"> header.app-header, .archive__header, .search__header { background-color: #ffffff; color: #00156b; } header.app-header a, .app-header__search-container input[type=search].search-form__field, .archive__header li.pagination__item--page a, .archive__header li.pagination__item--prev a, .archive__header li.pagination__item--next a, .archive__header a.pagination__mobile-link, .search__header li.pagination__item--page a, .search__header li.pagination__item--prev a, .search__header li.pagination__item--next a, .search__header a.pagination__mobile-link { color: #00156b; } .app-header__drawer-small-title, .app-header__container:after, .app-header__drawer:after, .app-header__nav-toggle span, .app-header__nav-toggle span:before, .app-header__nav-toggle span:after, a.app-header__nav-toggle span, a.app-header__nav-toggle span:before, a.app-header__nav-toggle span:after, ul.app-header__primary-nav > li.menu-item-has-children > a:after, ul.app-header__primary-nav > li.menu-item-has-children:hover > a:after, .app-header__search-container .search-form__label:before, .app-header__search-container .search-form__label:after, .app-header__search-container input[type=search].search-form__field, ul.app-header__primary-nav > li.current-menu-item > a, ul.app-header__primary-nav > li.current-page-ancestor > a, ul.app-header__primary-nav > li.menu-item-has-children > ul.sub-menu, .archive__header li.pagination__item--page a, .archive__header li.pagination__item--page a:hover, .archive__header li.pagination__item--page a:focus, .search__header li.pagination__item--page a, .search__header li.pagination__item--page a:hover, .search__header li.pagination__item--page a:focus { border-color: #00156b; } ul.app-header__primary-nav > li.current-menu-item > a:before, ul.app-header__primary-nav > li.current-page-ancestor > a:before { border-color: #ffffff; } .app-header .button.button--shortcode.button--s, .search__header input[type=submit] { border-color: #00156b; background: #00156b; color: #ffffff; } .app-header .button.button--shortcode.button--s:hover, .app-header .button.button--shortcode.button--s:focus, .search__header input[type=submit]:hover, .search__header input[type=submit]:focus { background: #00156b; color: #ffffff; opacity: 0.85; } ul.app-header__primary-nav > li.menu-item-has-children > ul.sub-menu, .app-header__search-container input[type=search].search-form__field, ul.app-header__primary-nav > li.current-menu-item > a, ul.app-header__primary-nav > li.current-page-ancestor > a { background-color: #ffffff; } .app-header__drawer a:not(.post-list__post-image), .archive__header li.pagination__item a, .archive__header a.pagination__mobile-link, .search__header li.pagination__item a, .search__header a.pagination__mobile-link { background-image: linear-gradient(#00156b, #00156b); } .app-header__drawer a:not(.post-list__post-image):hover, .app-header__drawer a:not(.post-list__post-image):focus, .archive__header li.pagination__item a:hover, .archive__header li.pagination__item a:focus, .archive__header a.pagination__mobile-link:hover, .archive__header a.pagination__mobile-link:focus, .search__header li.pagination__item a:hover, .search__header li.pagination__item a:focus, .search__header a.pagination__mobile-link:hover, .search__header a.pagination__mobile-link:focus { color: #ffffff; background-size: 100% 100%; background-position: 0% 100%; } .archive__header li.pagination__item--page.pagination__item--current a, .search__header li.pagination__item--page.pagination__item--current a { background-color: #00156b; border-color: #00156b; color: #ffffff; } .search__header form.search-form input[type=search] { background-color: #ffffff; border-color: #00156b; color: #00156b; } </style>  <script> /*! For license information please see head.js.LICENSE.txt */ (()=>{var e={773:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.VALID_PURPOSES=t.RECONSENT_INTERVAL=t.COOKIE_KEY=void 0,t.COOKIE_KEY="plosCookieConsentStatus",t.RECONSENT_INTERVAL=180,t.VALID_PURPOSES=["advertising","analytics","functionality"]},502:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var o,r=(o=n(808))&&o.__esModule?o:{default:o},i=n(773);function u(e){return Object.assign({},...i.VALID_PURPOSES.map((t=>({[t]:e}))))}var a={get:function(){try{const e=JSON.parse(r.default.get(i.COOKIE_KEY));return e?!0===e?u(!0):e:u(!1)}catch(e){return u(!1)}},isSet:function(){return void 0!==r.default.get(i.COOKIE_KEY)},remove:function(){r.default.remove(i.COOKIE_KEY)},set:function(e){const t=window.location.hostname;r.default.set(i.COOKIE_KEY,e,{domain:("localhost"===t?"":".")+t.split(".").slice(-2).join("."),expires:i.RECONSENT_INTERVAL})}};t.default=a},177:(e,t,n)=>{"use strict";t.default=void 0;var o,r=(o=n(502))&&o.__esModule?o:{default:o},i=n(773);function u(){var e,t;null===(e=(t=window).gtmOnConsent)||void 0===e||e.call(t,r.default.get())}var a={accept:function(){r.default.set(!0),u()},customize:function(e,t){r.default.set(Object.assign(r.default.get(),{[e]:t})),u()},hasConsented:function(e){if(!i.VALID_PURPOSES.includes(e))throw new Error("Invalid cookie purpose: "+e+" - Not in "+i.VALID_PURPOSES.toString());return r.default.get()[e]},hasInteracted:function(){return r.default.isSet()},reject:function(){r.default.set(!1),u()},reset:function(){r.default.remove()},VALID_PURPOSES:i.VALID_PURPOSES};t.default=a},808:(e,t,n)=>{var o,r,i;void 0===(r="function"==typeof(o=i=function(){function e(){for(var e=0,t={};e<arguments.length;e++){var n=arguments[e];for(var o in n)t[o]=n[o]}return t}function t(e){return e.replace(/(%[0-9A-Z]{2})+/g,decodeURIComponent)}return function n(o){function r(){}function i(t,n,i){if("undefined"!=typeof document){"number"==typeof(i=e({path:"/"},r.defaults,i)).expires&&(i.expires=new Date(1*new Date+864e5*i.expires)),i.expires=i.expires?i.expires.toUTCString():"";try{var u=JSON.stringify(n);/^[\{\[]/.test(u)&&(n=u)}catch(e){}n=o.write?o.write(n,t):encodeURIComponent(String(n)).replace(/%(23|24|26|2B|3A|3C|3E|3D|2F|3F|40|5B|5D|5E|60|7B|7D|7C)/g,decodeURIComponent),t=encodeURIComponent(String(t)).replace(/%(23|24|26|2B|5E|60|7C)/g,decodeURIComponent).replace(/[]/g,escape);var a="";for(var c in i)i[c]&&(a+="; "+c,!0!==i[c]&&(a+="="+i[c].split(";")[0]));return document.cookie=t+"="+n+a}}function u(e,n){if("undefined"!=typeof document){for(var r={},i=document.cookie?document.cookie.split("; "):[],u=0;u<i.length;u++){var a=i[u].split("="),c=a.slice(1).join("=");n||'"'!==c.charAt(0)||(c=c.slice(1,-1));try{var s=t(a[0]);if(c=(o.read||o)(c,s)||t(c),n)try{c=JSON.parse(c)}catch(e){}if(r[s]=c,e===s)break}catch(e){}}return e?r[e]:r}}return r.set=i,r.get=function(e){return u(e,!1)},r.getJSON=function(e){return u(e,!0)},r.remove=function(t,n){i(t,"",e(n,{expires:-1}))},r.defaults={},r.withConverter=n,r}((function(){}))})?o.call(t,n,t,e):o)||(e.exports=r),e.exports=i()}},t={};function n(o){var r=t[o];if(void 0!==r)return r.exports;var i=t[o]={exports:{}};return e[o](i,i.exports,n),i.exports}(()=>{"use strict";var e=n(177);window.plosCookieConsent=e.default})()})(); </script>  </head> <body class="home blog app-data index-data home-data front-page-data elementor-default elementor-kit-6575"> <a class="skip-to-content" href="#content">Skip to content</a> <div id="top"></div> <header class="app-header"> <div class="app-header__container container"> <a class="app-header__brand" href=//plos.org> <img class="app-header__logo" src="https://dnascience.plos.org/wp-content/uploads/2020/01/logo-sea.svg" alt="DNA Science logo" /> </a> <nav class="app-header__nav"> <div class="app-header__nav-row"> <div class="app-header__primary-nav-container"> <div class="menu-header-navigation-container"><ul id="menu-header-navigation" class="app-header__primary-nav"><li id="menu-item-411" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-411"><a href="https://plos.org/publish/">Publish with PLOS</a> <ul class="sub-menu"> <li id="menu-item-9363" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-9363"><a href="https://plos.org/your-journal-options/">Which Journal?</a></li> <li id="menu-item-1409" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1409"><a href="https://plos.org/publish/submit/">Submit</a></li> <li id="menu-item-2355" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2355"><a href="https://plos.org/publish/publishing-faqs/">Publishing FAQs</a></li> <li id="menu-item-2356" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2356"><a href="https://plos.org/publish/fees/">Fees</a></li> <li id="menu-item-2357" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2357"><a href="https://plos.org/pay-invoice/">Pay Invoice</a></li> <li id="menu-item-2358" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2358"><a href="https://plos.org/publish/metrics/">Metrics</a></li> <li id="menu-item-2359" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2359"><a href="https://plos.org/publish/funder-compliance/">Funder Compliance</a></li> <li id="menu-item-34242" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-34242"><a href="https://plos.org/research-integrity-and-ethics/">Research Integrity and Publication Ethics</a></li> </ul> </li> <li id="menu-item-307" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-307"><a href="https://plos.org/research-communities/">Research Communities</a></li> <li id="menu-item-384" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-384"><a href="https://plos.org/open-science/">Open Science</a> <ul class="sub-menu"> <li id="menu-item-18582" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-18582"><a href="https://plos.org/open-science/open-access/">Open Access</a></li> <li id="menu-item-16399" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-16399"><a href="https://plos.org/open-science/preprints/">Preprints</a></li> <li id="menu-item-17362" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-17362"><a href="https://plos.org/open-science/open-data/">Open Data</a></li> <li id="menu-item-9918" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-9918"><a href="https://plos.org/open-science/open-methods/">Open Methods</a></li> <li id="menu-item-7116" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-7116"><a href="https://plos.org/protocols/">Protocols</a></li> <li id="menu-item-17916" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-17916"><a href="https://plos.org/open-science/preregistration/">Preregistration</a></li> <li id="menu-item-17327" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-17327"><a href="https://plos.org/open-science/open-code/">Open Code</a></li> <li id="menu-item-2361" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2361"><a href="https://plos.org/published-peer-review-history/">Published Peer Review History</a></li> <li id="menu-item-16833" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-16833"><a href="https://plos.org/open-science/credit/">Credit</a></li> </ul> </li> <li id="menu-item-260" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-260"><a href="https://plos.org/resources/">Resources</a> <ul class="sub-menu"> <li id="menu-item-692" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-692"><a href="https://plos.org/resources/for-institutions/">For Institutions</a></li> <li id="menu-item-5291" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-5291"><a href="https://plos.org/media/">Press and Media</a></li> <li id="menu-item-8642" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-8642"><a href="https://plos.org/resources/editor-center/">Editor Center</a></li> <li id="menu-item-425" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-425"><a href="https://plos.org/resources/for-reviewers/">Peer Review Center</a></li> <li id="menu-item-16410" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-16410"><a href="https://plos.org/research-by-plos/">Research by PLOS</a></li> <li id="menu-item-5004" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-5004"><a href="https://plos.org/resources/writing-center/">Writing Center</a></li> </ul> </li> <li id="menu-item-420" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-420"><a href="https://plos.org/about/">About PLOS</a></li> </ul></div> </div> <div class="app-header__nav-controls"> <div class="app-header__search-container"> <form role="search" method="get" class="search-form" action="//plos.org"> <label class="search-form__label" for="s"><span class="screen-reader-text">Search:</span></label> <input type="search" class="search-form__field" value="" name="s" id="s" /> <input type="submit" class="search-form__submit" value="Search" /> </form> </div> <a class="app-header__nav-toggle" href="#"><span>Menu</span></a> </div> </div> </nav> </div> <div class="app-header__drawer"> <div class="app-header__drawer-container"> <div class="app-header__drawer-col app-header__drawer-content"> <div class="app-header__drawer-rich-text"> <p><span style="font-weight: 400;">When you choose to publish with PLOS, your research makes an impact. Make your work accessible to all, without restrictions, and accelerate scientific discovery with options like preprints and published peer review that make your work more Open.</span></p> <div class="acf-label"> <p class="description"></p> </div> </div> </div> <div class="app-header__drawer-col app-header__drawer-nav"> <span class="app-header__drawer-small-title">Journals</span> <div class="menu-journals-container"><ul id="menu-journals" class="app-header__drawer-menu app-header__drawer-menu--1"><li id="menu-item-275" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-275"><a href="https://journals.plos.org/plosbiology/">PLOS Biology</a></li> <li id="menu-item-8531" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8531"><a href="https://journals.plos.org/climate">PLOS Climate</a></li> <li id="menu-item-31915" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-31915"><a href="https://journals.plos.org/complexsystems/">PLOS Complex Systems</a></li> <li id="menu-item-276" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-276"><a href="https://journals.plos.org/ploscompbiol/">PLOS Computational Biology</a></li> <li id="menu-item-8535" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8535"><a href="https://journals.plos.org/digitalhealth">PLOS Digital Health</a></li> <li id="menu-item-277" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-277"><a href="https://journals.plos.org/plosgenetics/">PLOS Genetics</a></li> <li id="menu-item-8534" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8534"><a href="https://journals.plos.org/globalpublichealth">PLOS Global Public Health</a></li> <li id="menu-item-278" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-278"><a href="https://journals.plos.org/plosmedicine/">PLOS Medicine</a></li> <li id="menu-item-31916" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-31916"><a href="https://journals.plos.org/mentalhealth/">PLOS Mental Health</a></li> <li id="menu-item-279" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-279"><a href="https://journals.plos.org/plosntds/">PLOS Neglected Tropical Diseases</a></li> <li id="menu-item-280" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-280"><a href="https://journals.plos.org/plosone/">PLOS ONE</a></li> <li id="menu-item-281" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-281"><a href="https://journals.plos.org/plospathogens/">PLOS Pathogens</a></li> <li id="menu-item-8533" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8533"><a href="https://journals.plos.org/sustainabilitytransformation">PLOS Sustainability and Transformation</a></li> <li id="menu-item-8532" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8532"><a href="https://journals.plos.org/water">PLOS Water</a></li> </ul></div> </div> <div class="app-header__drawer-col app-header__drawer-nav"> <span class="app-header__drawer-small-title">More Content</span> <div class="menu-more-content-container"><ul id="menu-more-content" class="app-header__drawer-menu app-header__drawer-menu--2"><li id="menu-item-282" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-282"><a href="https://plos.org/blogs/">PLOS Blogs</a></li> <li id="menu-item-283" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-283"><a href="https://collections.plos.org/">PLOS Collections</a></li> </ul></div> </div> </div> </div> </header> <style>.blog-header__background { background-image: url(https://dnascience.plos.org/wp-content/uploads/sites/12/2020/05/DNA-blog-header.jpg); }.blog-header__text { color: #ffffff }.blog-header__author-orcid { color: #ffffff }.blog-header__orcid-icon { background-color: #ffffff }</style><div class="blog-header"> <div class="blog-header__text"> <span class="blog-header__label">PLOS BLOGS</span> <a class="blog-header__blog-name" href="https://dnascience.plos.org">DNA Science</a> <p class="blog-header__blog-description">Geneticist Ricki Lewis blogs from the cutting edge of genomics, including genetic testing, stem cells, gene therapy and more.</p> <div class="blog-header__background"></div> </div> <div class="blog-header__blogs-navigation blogs-navigation"> <div class="blogs-navigation__container"> <a class="blogs-navigation__mobile-toggle"><span></span>Browse all PLOS Blogs</a> <div class="blogs-navigation__mobile-container"> <div class="blogs-navigation__main-menu-container"> <div class="menu-blog-navigation-container"><ul id="menu-blog-navigation" class="blogs-navigation__main-menu"><li id="menu-item-4099" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-4099"><a href="https://dnascience.plos.org/about-this-blog/">About This Blog</a></li> </ul></div> </div> <div class="blogs-navigation__drawer"> <a class="blogs-navigation__drawer-toggle"><span></span>Browse all PLOS Blogs</a> <div class="blogs-navigation__drawer-menu-container"> <div class="menu-blogs-menu-container"><ul id="menu-blogs-menu" class="blogs-navigation__drawer-menu"><li id="menu-item-3654" class="mega-parent menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3654"><a href="#">Staff Blogs</a> <ul class="sub-menu"> <li id="menu-item-3655" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3655"><a href="https://theplosblog.plos.org">Official PLOS Blog</a></li> <li id="menu-item-3656" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3656"><a href="http://everyone.plos.org">EveryONE Blog</a></li> <li id="menu-item-9185" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-9185"><a href="https://latitude.plos.org/">Latitude</a></li> <li id="menu-item-3657" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3657"><a href="https://speakingofmedicine.plos.org">Speaking of Medicine</a></li> <li id="menu-item-3658" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3658"><a href="https://biologue.plos.org">PLOS Biologue</a></li> <li id="menu-item-3659" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3659"><a href="https://collectionsblog.plos.org/">PLOS Collections</a></li> </ul> </li> <li id="menu-item-3660" class="mega-parent menu-item menu-item-type-custom menu-item-object-custom current-menu-ancestor current-menu-parent menu-item-has-children menu-item-3660"><a href="#">Independent Blogs</a> <ul class="sub-menu"> <li id="menu-item-3661" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3661"><a href="https://absolutelymaybe.plos.org">Absolutely Maybe</a></li> <li id="menu-item-3662" class="menu-item menu-item-type-custom menu-item-object-custom current-menu-item menu-item-3662"><a href="https://dnascience.plos.org" aria-current="page">DNA Science</a></li> <li id="menu-item-3663" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3663"><a href="https://ecrcommunity.plos.org">PLOS ECR Community</a></li> <li id="menu-item-3664" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3664"><a href="https://scicomm.plos.org">SciComm</a></li> <li id="menu-item-3665" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3665"><a href="https://allmodels.plos.org">All Models Are Wrong</a></li> <li id="menu-item-3896" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3896"><a href="https://yoursay.plos.org">Your Say</a></li> </ul> </li> <li id="menu-item-3666" class="mega-parent menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3666"><a href="#">About</a> <ul class="sub-menu"> <li id="menu-item-3821" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-3821"><a href="https://plos.org/blogs/about/">About PLOS Blogs</a></li> <li id="menu-item-3820" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-3820"><a href="https://plos.org/blogs/contact/">Contact</a></li> </ul> </li> </ul></div> </div> </div> </div> </div> </div> </div> <div class="wrap" role="document"> <div class="content" id="content"> <main class="main"> <div class="archive"> <div class="archive__posts"> <form class="archive-filters archive__filters" data-permalink-base="https://dnascience.plos.org"> <fieldset> <legend>Filter Posts</legend> <div class="archive-filters__container"> <div class="archive-filters__control-container"> <label for="archive-filters__control--search">Search</label> <input type="text" id="archive-filters__control--search" data-name="search" class="archive-filters__control" /> </div> <div class="archive-filters__control-container"> <label for="archive-filters__control--date">Year</label> <select id="archive-filters__control--date" data-name="date" class="archive-filters__control"> <option value="" >All years</option> <option value="2024" >2024</option> <option value="2023" >2023</option> <option value="2022" >2022</option> <option value="2021" >2021</option> <option value="2020" >2020</option> <option value="2019" >2019</option> <option value="2018" >2018</option> <option value="2017" >2017</option> <option value="2016" >2016</option> <option value="2015" >2015</option> <option value="2014" >2014</option> <option value="2013" >2013</option> <option value="2012" >2012</option> </select> </div> <div class="archive-filters__control-container"> <label for="archive-filters__control--category">Category</label> <select id="archive-filters__control--category" data-name="category" class="archive-filters__control"> <option value="" >Show all</option> <option value="genedx" >genedx</option> <option value="uncategorized" >Uncategorized</option> </select> </div> <div class="archive-filters__control-container"> <label for="archive-filters__control--post_tag">Tag</label> <select id="archive-filters__control--post_tag" data-name="post_tag" class="archive-filters__control"> <option value="" >Show all</option> <option value="metoo" >#MeToo</option> <option value="101-b-h" >10:1 B/H</option> <option value="10x-genomics" >10x Genomics</option> <option value="17-timepoints" >17 Timepoints</option> <option value="1918-flu" >1918 flu</option> <option value="21rst-century-cures-act" >21rst Century Cures Act</option> <option value="21st-century-cures-initiative" >21st Century Cures Initiative</option> <option value="22q-deletion-syndrome" >22q deletion syndrome</option> <option value="23andme" >23andMe</option> <option value="3-parent-baby" >3-parent baby</option> <option value="3-parent-ivf" >3-parent IVF</option> <option value="44-chromosome-human-karyotype" >44 chromosome human karyotype</option> <option value="99-lives-project" >99 Lives Project</option> <option value="a-cure-for-ellie" >A Cure for Ellie</option> <option value="a1c" >A1C</option> <option value="aacr" >AACR</option> <option value="aav" >AAV</option> <option value="abbies" >Abbies</option> <option value="abo" >ABO</option> <option value="abortion" >abortion</option> <option value="abortion-rights" >abortion rights</option> <option value="abraham-verghese" >Abraham Verghese</option> <option value="achondroplasia" >achondroplasia</option> <option value="achromatopsia" >achromatopsia</option> <option value="acmg" >ACMG</option> <option value="ada-deficiency" >ADA deficiency</option> <option value="adam-lanza" >Adam Lanza</option> <option value="adrenoleukodystrophy" >adrenoleukodystrophy</option> <option value="aducanumab" >Aducanumab</option> <option value="adult-polyglucosan-body-disease" >adult polyglucosan body disease</option> <option value="agbiotech" >agbiotech</option> <option value="age-related-macular-degeneration" >age-related macular degeneration</option> <option value="aging" >aging</option> <option value="ahca" >AHCA</option> <option value="ai" >AI</option> <option value="aicardi-syndrome" >Aicardi syndrome</option> <option value="aids" >AIDS</option> <option value="ailey-garfield" >Ailey Garfield</option> <option value="aku" >AKU</option> <option value="albert-sabin" >Albert Sabin</option> <option value="ald" >ALD</option> <option value="alfred-henry-sturtevant" >Alfred Henry Sturtevant</option> <option value="alina-chan" >Alina Chan</option> <option value="aliria" >Aliria</option> <option value="alkaptonuria" >alkaptonuria</option> <option value="allergen-free-cat" >allergen-free cat</option> <option value="almond" >almond</option> <option value="alpha-synuclein" >alpha synuclein</option> <option value="als" >ALS</option> <option value="alstrom-syndrome" >Alstrom syndrome</option> <option value="alternative-facts" >alternative facts</option> <option value="alzheimer" >Alzheimer</option> <option value="alzheimers-disease" >Alzheimer's disease</option> <option value="amber-olsen" >Amber Olsen</option> <option value="ambras-syndrome" >Ambras syndrome</option> <option value="ambry-genetics" >Ambry Genetics</option> <option value="amd" >AMD</option> <option value="american-health-care-act" >American Health Care Act</option> <option value="american-society-of-gene-cell-therapy" >American Society of Gene & Cell Therapy</option> <option value="american-society-of-gene-and-cell-therapy" >American Society of Gene and Cell Therapy</option> <option value="american-society-of-human-genetics" >American Society of Human Genetics</option> <option value="amish" >Amish</option> <option value="amniocentesis" >amniocentesis</option> <option value="amyloid-beta" >amyloid beta</option> <option value="amyotrophic-lateral-sclerosis" >amyotrophic lateral sclerosis</option> <option value="ancestry-testing" >ancestry testing</option> <option value="ancestry-com" >ancestry.com</option> <option value="ancestrydna" >AncestryDNA</option> <option value="ancient-dna" >ancient DNA</option> <option value="ancient-flowers" >ancient flowers</option> <option value="ancient-fragrance" >ancient fragrance</option> <option value="ancient-perfume" >ancient perfume</option> <option value="andrew-wakefield" >Andrew Wakefield</option> <option value="anencephaly" >anencephaly</option> <option value="angelina-jolie-effect" >Angelina Jolie effect</option> <option value="angelman-syndrome" >Angelman Syndrome</option> <option value="animal-models" >animal models</option> <option value="animal-testing" >animal testing</option> <option value="ann-wilson" >Ann Wilson</option> <option value="anosmia" >anosmia</option> <option value="anthony-allison" >Anthony Allison</option> <option value="anthony-fauci" >Anthony Fauci</option> <option value="anthony-weiner" >Anthony Weiner</option> <option value="anti-aging" >anti-aging</option> <option value="anti-oxidant" >anti-oxidant</option> <option value="anti-science" >anti-science</option> <option value="anti-vaxxer" >anti-vaxxer</option> <option value="antibodies" >antibodies</option> <option value="antibody-cocktail" >antibody cocktail</option> <option value="antibody-dependent-enhancement" >antibody dependent enhancement</option> <option value="antibody-medicine" >antibody medicine</option> <option value="antisemitism" >antisemitism</option> <option value="antisense" >antisense</option> <option value="apocalypse" >apocalypse</option> <option value="apoe" >APOE</option> <option value="apolipoproteina" >apolipoprotein(a)</option> <option value="apollo" >Apollo</option> <option value="appendix-cancer" >appendix cancer</option> <option value="apple" >Apple</option> <option value="apple-tv" >Apple TV+</option> <option value="applied-genetic-technologies-corp" >Applied Genetic Technologies Corp</option> <option value="arabica" >Arabica</option> <option value="archibald-garrod" >Archibald Garrod</option> <option value="arlo-guthrie" >Arlo Guthrie</option> <option value="array-cgh" >array CGH</option> <option value="art-caplan" >Art Caplan</option> <option value="arthritis" >arthritis</option> <option value="artificial-intelligence" >artificial intelligence</option> <option value="aryan" >Aryan</option> <option value="asco" >ASCO</option> <option value="asgct" >ASGCT</option> <option value="ashg" >ASHG</option> <option value="asian-genetics" >Asian genetics</option> <option value="atherosclerosis" >atherosclerosis</option> <option value="atp12a" >ATP12A</option> <option value="auctioning-nobel-prize" >auctioning Nobel Prize</option> <option value="audentes-therapeutics" >Audentes Therapeutics</option> <option value="auschwitz" >Auschwitz</option> <option value="aussiedoodle" >aussiedoodle</option> <option value="australian-rabbits" >Australian rabbits</option> <option value="authors-guild" >Author's Guild</option> <option value="autism" >autism</option> <option value="autism-speaks" >Autism Speaks</option> <option value="autoimmune" >autoimmune</option> <option value="avastin" >Avastin</option> <option value="avellino-laboratory" >Avellino Laboratory</option> <option value="avian-influenza" >Avian influenza</option> <option value="avidity-biosciences" >Avidity Biosciences</option> <option value="ba-1" >BA.1</option> <option value="ba-2" >BA.2</option> <option value="baboon" >baboon</option> <option value="babys-first-test" >Baby's First Test</option> <option value="babyseq" >BabySeq</option> <option value="bainbridge-ropers" >Bainbridge-Ropers</option> <option value="balanced-polymorphism" >balanced polymorphism</option> <option value="bandersnatch" >Bandersnatch</option> <option value="base-editing" >base editing</option> <option value="batten-disease" >Batten disease</option> <option value="baylor-college-of-medicine" >Baylor College of Medicine</option> <option value="bc" >BC</option> <option value="bcg" >BCG</option> <option value="beef" >beef</option> <option value="behavioral-genetics" >behavioral genetics</option> <option value="believe-in-science" >believe in science</option> <option value="benita-zahn" >Benita Zahn</option> <option value="bernardo-lemos" >Bernardo Lemos</option> <option value="beta-thalassemia" >beta thalassemia</option> <option value="between" >Between</option> <option value="bidil" >BiDil</option> <option value="binaxnow" >BinaxNOW</option> <option value="bioethics" >bioethics</option> <option value="bioinformatics" >bioinformatics</option> <option value="biological-aging" >biological aging</option> <option value="biology-textbook" >biology textbook</option> <option value="biomarin" >BioMarin</option> <option value="bionano" >Bionano</option> <option value="bioprospecting" >bioprospecting</option> <option value="biorxiv" >bioRxiv</option> <option value="bioterror" >bioterror</option> <option value="bioweapon" >bioweapon</option> <option value="bird-flu" >bird flu</option> <option value="birth-defects" >birth defects</option> <option value="black-mirror" >Black Mirror</option> <option value="bladder-cancer" >bladder cancer</option> <option value="blindness" >blindness</option> <option value="blindness-awareness-month" >blindness awareness month</option> <option value="blue-people-of-troublesome-creek" >blue people of Troublesome creek</option> <option value="bluebird-bio" >bluebird bio</option> <option value="bonnie-garmus" >Bonnie Garmus</option> <option value="booger" >booger</option> <option value="botticelli" >Botticelli</option> <option value="brain-disease" >brain disease</option> <option value="brainex" >BrainEx</option> <option value="brca" >BRCA</option> <option value="brca1" >BRCA1</option> <option value="brca2" >BRCA2</option> <option value="breakthrough-of-the-year" >Breakthrough of the Year</option> <option value="breast-cancer" >breast cancer</option> <option value="breast-cancer-james-madison-high-school" >breast cancer. James Madison High School</option> <option value="bree-walker" >Bree Walker</option> <option value="brett-cavanaugh" >Brett Cavanaugh</option> <option value="brian-j-druker" >Brian J Druker</option> <option value="brisdelta" >BriSdelta</option> <option value="brit-bennett" >Brit Bennett</option> <option value="brittle-bone-disease" >brittle bone disease</option> <option value="bruce-springsteen" >Bruce Springsteen</option> <option value="bryon-petersen" >Bryon Petersen</option> <option value="bubble-boy" >bubble boy</option> <option value="burger" >burger</option> <option value="burning-man-syndrome" >burning man syndrome</option> <option value="butt-sniffing" >butt sniffing</option> <option value="butternut-squash" >butternut squash</option> <option value="calico-cats" >calico cats</option> <option value="call-the-midwife" >Call the Midwife</option> <option value="cambodian-bats" >Cambodian bats</option> <option value="canavan-disease" >Canavan disease</option> <option value="canavan-research-illinois" >Canavan Research Illinois</option> <option value="cancer" >cancer</option> <option value="candida-auris" >Candida auris</option> <option value="car-t" >CAR-T</option> <option value="carbs" >carbs</option> <option value="cardiovascular-disease" >cardiovascular disease</option> <option value="carrier-screen" >carrier screen</option> <option value="cat-allergy" >cat allergy</option> <option value="cat-dna" >cat DNA</option> <option value="cat-genome" >cat genome</option> <option value="cataract" >cataract</option> <option value="cataracts" >cataracts</option> <option value="cats" >cats</option> <option value="catskill-game-farm" >Catskill Game Farm</option> <option value="cd33" >CD33</option> <option value="cdc" >CDC</option> <option value="cell-cycle" >cell cycle</option> <option value="cell-therapy" >cell therapy</option> <option value="cell-free-fetal-dna" >cell-free fetal DNA</option> <option value="center-for-genetics-and-society" >Center for Genetics and Society</option> <option value="centimorgan" >centiMorgan</option> <option value="central-dogma" >central dogma</option> <option value="centre-for-palaeogenetics" >Centre for Palaeogenetics</option> <option value="cephalopod" >cephalopod</option> <option value="cerebral-cortex" >cerebral cortex</option> <option value="cerezyme" >Cerezyme</option> <option value="cfdna" >cfDNA</option> <option value="cftr" >CFTR</option> <option value="cgd" >CGD</option> <option value="charcot-marie-tooth-disease" >Charcot-Marie-Tooth disease</option> <option value="charlie-gard" >Charlie Gard</option> <option value="charlotte-and-gwenyth-gray-foundation" >Charlotte and Gwenyth Gray Foundation</option> <option value="chatgtp" >ChatGTP</option> <option value="chdi" >CHDI</option> <option value="chernobyl" >Chernobyl</option> <option value="chernobyl-dog-research-initiative" >Chernobyl Dog Research Initiative</option> <option value="chewing-gum" >chewing gum</option> <option value="chicken" >chicken</option> <option value="chickenpox" >chickenpox</option> <option value="chief" >CHIEF</option> <option value="childrens-mercy-kansas-city" >Children's Mercy: Kansas City</option> <option value="chloes-law" >Chloe's Law</option> <option value="cholesterol" >cholesterol</option> <option value="choosing-passwords" >choosing passwords</option> <option value="chorionic-villus-sampling" >chorionic villus sampling</option> <option value="choroideremia" >choroideremia</option> <option value="christchurch-mutation" >Christchurch mutation</option> <option value="christian-guardino" >Christian Guardino</option> <option value="christina-crise" >Christina Crise</option> <option value="christine-blasey-ford" >Christine Blasey Ford</option> <option value="chromosomal-microarray" >chromosomal microarray</option> <option value="chromosome-mosaic" >chromosome mosaic</option> <option value="chromosomes" >chromosomes</option> <option value="chromothripsis" >chromothripsis</option> <option value="chronic-myeloid-leukemia" >chronic myeloid leukemia</option> <option value="cleft-hand" >cleft hand</option> <option value="clemizole" >clemizole</option> <option value="climate-denier" >climate denier</option> <option value="clinic-for-special-children" >Clinic for Special Children</option> <option value="clinical-trial" >clinical trial</option> <option value="clinical-trials" >clinical trials</option> <option value="clinicaltrials-gov" >clinicaltrials.gov</option> <option value="clinseq" >ClinSeq</option> <option value="clinvar" >ClinVar</option> <option value="cln1" >CLN1</option> <option value="cloning" >cloning</option> <option value="clostridium-difficile" >Clostridium difficile</option> <option value="cmt" >CMT</option> <option value="cmt4j" >CMT4J</option> <option value="coeoid" >coeoid</option> <option value="coffea-arabica" >Coffea arabica</option> <option value="coffee" >coffee</option> <option value="col7a1" >COL7A1</option> <option value="coleys-toxins" >Coley's toxins</option> <option value="colon-cancer" >colon cancer</option> <option value="complete-genomics" >Complete Genomics</option> <option value="congenital-generalized-lipodystrophy" >congenital generalized lipodystrophy</option> <option value="conjoined-twins" >conjoined twins</option> <option value="connectome" >connectome</option> <option value="copper" >copper</option> <option value="copy-number-variant" >copy number variant</option> <option value="coronavirus" >coronavirus</option> <option value="costa-rica" >Costa Rica</option> <option value="counsyl" >Counsyl</option> <option value="covid" >COVID</option> <option value="covid-anosmia" >COVID anosmia</option> <option value="covid-thanksgiving" >COVID Thanksgiving</option> <option value="covid-vaccine" >COVID vaccine</option> <option value="covid-vaccines" >COVID vaccines</option> <option value="covid-19" >COVID-19</option> <option value="covid-19-vaccine" >COVID-19 vaccine</option> <option value="coyote" >coyote</option> <option value="craig-venter" >Craig Venter</option> <option value="crb1" >CRB1</option> <option value="creating-life" >creating life</option> <option value="creation" >creation</option> <option value="crime-gene" >crime gene</option> <option value="crispr" >CRISPR</option> <option value="crispr-cas9" >CRISPR-Cas9</option> <option value="crispr-cas-9" >CRISPR/Cas-9</option> <option value="crossing-over" >crossing over</option> <option value="cttnnd2" >CTTNND2</option> <option value="cucurbitaceae" >Cucurbitaceae</option> <option value="curcumin" >curcumin</option> <option value="curcumrx" >CurcumRx</option> <option value="cure-sanfilippo-foundation" >Cure Sanfilippo Foundation</option> <option value="cure-sma" >Cure SMA</option> <option value="curing-retinal-blindness-foundation" >Curing Retinal Blindness Foundation</option> <option value="cutaneous-melanoma" >cutaneous melanoma</option> <option value="cuttlefish" >cuttlefish</option> <option value="cutx-101" >CUTX-101</option> <option value="cyprium" >Cyprium</option> <option value="cystic-fibrosis" >cystic fibrosis</option> <option value="cytogenetics" >cytogenetics</option> <option value="cytoskeleton" >cytoskeleton</option> <option value="d614" >D614</option> <option value="dan-brown" >Dan Brown</option> <option value="dantes-inferno" >Dante's Inferno</option> <option value="david-reich" >David Reich</option> <option value="dcis" >DCIS</option> <option value="de-extinction" >de-extinction</option> <option value="deaf" >deaf</option> <option value="dean-hamer" >Dean Hamer</option> <option value="decode-genetics" >deCODE Genetics</option> <option value="deep-vein-thrombosis" >deep vein thrombosis</option> <option value="deextinction" >deextinction</option> <option value="dei" >DEI</option> <option value="delta-variant" >delta variant</option> <option value="dementia" >dementia</option> <option value="demogorgon" >demogorgon</option> <option value="denisovans" >Denisovans</option> <option value="depression" >depression</option> <option value="designer-babies" >designer babies</option> <option value="designer-baby" >designer baby</option> <option value="developmental-biology" >developmental biology</option> <option value="developmental-delay" >developmental delay</option> <option value="devil-facial-tumor-1" >devil facial tumor 1</option> <option value="dft1" >DFT1</option> <option value="diabetes" >diabetes</option> <option value="diana-bianchi" >Diana Bianchi</option> <option value="dickkopf-4" >dickkopf 4</option> <option value="diet" >diet</option> <option value="dinosaurs" >dinosaurs</option> <option value="direct-to-consumer-genetic-testing" >direct-to-consumer genetic testing</option> <option value="direct-to-consumer-testing" >direct-to-consumer testing</option> <option value="diversity-equity-inclusion" >diversity equity inclusion</option> <option value="dmd" >DMD</option> <option value="dna" >DNA</option> <option value="dna-ancestry-testing" >DNA ancestry testing</option> <option value="dna-and-dating" >DNA and dating</option> <option value="dna-and-god" >DNA and God</option> <option value="dna-and-religion" >DNA and religion</option> <option value="dna-databases" >DNA databases</option> <option value="dna-day" >DNA Day</option> <option value="dna-discovery" >DNA discovery</option> <option value="dna-profiling" >DNA profiling</option> <option value="dna-science" >DNA Science</option> <option value="do-your-own-research" >do your own research</option> <option value="dobbs-v-jackson" >Dobbs v Jackson</option> <option value="donald-cline" >Donald Cline</option> <option value="donald-trump" >Donald Trump</option> <option value="donanemab" >Donanemab</option> <option value="donor-sibling" >donor sibling</option> <option value="doodle" >doodle</option> <option value="dopamine-receptor" >dopamine receptor</option> <option value="dor-yeshorim" >Dor Yeshorim</option> <option value="douglas-preston" >Douglas Preston</option> <option value="down-syndrome" >Down syndrome</option> <option value="drosophila" >Drosophila</option> <option value="drug-addiction" >drug addiction</option> <option value="drug-prices" >drug prices</option> <option value="drug-drug-interactions" >drug-drug interactions</option> <option value="duchenne-muscular-dystrophy" >Duchenne muscular dystrophy</option> <option value="dusan-bogunovic" >Dusan Bogunovic</option> <option value="duvyzat" >Duvyzat</option> <option value="dyor" >DYOR</option> <option value="dystopia" >dystopia</option> <option value="dystrophic-epidermolysis-bullosa" >dystrophic epidermolysis bullosa</option> <option value="dystrophin" >dystrophin</option> <option value="early-pregnancy-loss" >early pregnancy loss</option> <option value="eating-insects" >eating insects</option> <option value="ebola" >Ebola</option> <option value="ebola-virus-disease" >Ebola virus disease</option> <option value="ectrodactyly" >ectrodactyly</option> <option value="edna" >eDNA</option> <option value="edon" >EDoN</option> <option value="edward-jenner" >Edward Jenner</option> <option value="egfr" >eGFR</option> <option value="egg-freezing" >egg freezing</option> <option value="ehlers-danlos-syndrome" >Ehlers-Danlos syndrome</option> <option value="eid" >EID</option> <option value="eimear-kenny" >Eimear Kenny</option> <option value="eliza-oneill" >Eliza O'Neill</option> <option value="elizabeth-warren" >Elizabeth Warren</option> <option value="elizabeth-zott" >Elizabeth Zott</option> <option value="embryo" >embryo</option> <option value="embryo-selection" >embryo selection</option> <option value="embryoid-body" >embryoid body</option> <option value="embryonic-engineering" >embryonic engineering</option> <option value="emergency-use-authorization" >emergency use authorization</option> <option value="emerging-infectious-diseases" >Emerging Infectious Diseases</option> <option value="emily-st-john-mandel" >Emily St. John Mandel</option> <option value="emmanuel-gokpolu" >Emmanuel Gokpolu</option> <option value="emmanuelle-charpentier" >Emmanuelle Charpentier</option> <option value="emory" >Emory</option> <option value="end-of-the-world" >end-of-the-world</option> <option value="environmental-dna" >environmental DNA</option> <option value="enzyme-replacement-therapy" >enzyme replacement therapy</option> <option value="enzyme-substitution-therapy" >enzyme substitution therapy</option> <option value="epidemiology" >epidemiology</option> <option value="epidermolysis-bullosa" >epidermolysis bullosa</option> <option value="epigenetics" >epigenetics</option> <option value="eran-elinav" >Eran Elinav</option> <option value="eric-green" >Eric Green</option> <option value="eruption" >Eruption</option> <option value="eteplirsen" >eteplirsen</option> <option value="eugenics" >eugenics</option> <option value="eurekalert" >Eurekalert</option> <option value="european-medicine-agency" >European Medicine Agency</option> <option value="euthanasia" >euthanasia</option> <option value="evo-devo" >evo-devo</option> <option value="evolution" >evolution</option> <option value="exaptation" >exaptation</option> <option value="exome" >exome</option> <option value="exome-sequencing" >exome sequencing</option> <option value="exon" >exon</option> <option value="exon-skipping" >exon skipping</option> <option value="exondys-51" >Exondys 51</option> <option value="exosomes" >exosomes</option> <option value="expanding-repeat" >expanding repeat</option> <option value="experimental-pop-concert" >experimental pop concert</option> <option value="extant" >Extant</option> <option value="extinction" >extinction</option> <option value="eye-color" >eye color</option> <option value="facebook" >Facebook</option> <option value="false-positive" >False Positive</option> <option value="familial-dysautonomia" >familial dysautonomia</option> <option value="family-history" >family history</option> <option value="farnesyl" >farnesyl</option> <option value="fauci" >Fauci</option> <option value="fbi-codis" >FBI CODIS</option> <option value="fda" >FDA</option> <option value="fecal-microbiota-transplantation" >fecal microbiota transplantation</option> <option value="fecal-transplant" >fecal transplant</option> <option value="feces" >feces</option> <option value="federal-budget" >federal budget</option> <option value="fel-d-1" >Fel d 1</option> <option value="feline-immunodeficiency-virus" >feline immunodeficiency virus</option> <option value="felv" >FeLV</option> <option value="feminism" >feminism</option> <option value="fertility-fraud" >fertility fraud</option> <option value="fetal-genome" >fetal genome</option> <option value="fetus-in-fetu" >fetus-in-fetu</option> <option value="fibrodysplasia-ossificans-progressiva" >fibrodysplasia ossificans progressiva</option> <option value="fight-sma" >Fight SMA</option> <option value="fiv" >FIV</option> <option value="flu" >flu</option> <option value="flu-vaccine" >flu vaccine</option> <option value="forensic-entomology" >forensic entomology</option> <option value="foundation-fighting-blindness" >Foundation Fighting Blindness</option> <option value="foundation-for-retinal-research" >Foundation for Retinal Research</option> <option value="frameshift-mutation" >frameshift mutation</option> <option value="francis-collins" >Francis Collins</option> <option value="francis-crick" >Francis Crick</option> <option value="francis-galton" >Francis Galton</option> <option value="frank-underwood" >Frank Underwood</option> <option value="front-line-genomics" >Front Line Genomics</option> <option value="fructose" >fructose</option> <option value="functional-genomics" >functional genomics</option> <option value="fundraising" >fundraising</option> <option value="funginet" >FungiNet</option> <option value="furin-cleavage-site" >furin cleavage site</option> <option value="future-society" >Future Society</option> <option value="gan" >GAN</option> <option value="gastruloids" >gastruloids</option> <option value="gaten" >Gaten</option> <option value="gattaca" >GATTACA</option> <option value="gaucher-disease" >Gaucher disease</option> <option value="gavins-groupies" >Gavin's Groupies</option> <option value="gay-pride" >gay pride</option> <option value="genderqueer" >genderqueer</option> <option value="gene-editing" >gene editing</option> <option value="gene-expression" >gene expression</option> <option value="gene-therapy" >gene therapy</option> <option value="genedx" >GeneDx</option> <option value="genepeeks" >GenePeeks</option> <option value="genes-in-space" >Genes in Space</option> <option value="genetic-code" >genetic code</option> <option value="genetic-counseling" >genetic counseling</option> <option value="genetic-counselor" >genetic counselor</option> <option value="genetic-determinism" >genetic determinism</option> <option value="genetic-disease" >genetic disease</option> <option value="genetic-enhancement" >genetic enhancement</option> <option value="genetic-heterogeneity" >genetic heterogeneity</option> <option value="genetic-modification" >genetic modification</option> <option value="genetic-modifiers" >genetic modifiers</option> <option value="genetic-privacy" >genetic privacy</option> <option value="genetic-screening" >genetic screening</option> <option value="genetic-superheroes" >genetic superheroes</option> <option value="genetic-testing" >genetic testing</option> <option value="genetically-modified-organisms" >genetically modified organisms</option> <option value="genetics" >genetics</option> <option value="genetics-education" >genetics education</option> <option value="genetics-textbook" >genetics textbook</option> <option value="genome" >genome</option> <option value="genome-cloaking" >genome cloaking</option> <option value="genome-editing" >genome editing</option> <option value="genome-graph" >genome graph</option> <option value="genome-sequence" >genome sequence</option> <option value="genome-sequencing" >genome sequencing</option> <option value="genomic-epidemiology" >genomic epidemiology</option> <option value="genomic-postportem-research-project" >Genomic Postportem Research Project</option> <option value="genomically-recoded-organisms" >genomically recoded organisms</option> <option value="genomics" >genomics</option> <option value="genotype-tissue-expression-project" >Genotype-Tissue Expression Project</option> <option value="genzyme" >Genzyme</option> <option value="george-church" >George Church</option> <option value="george-floyd" >George Floyd</option> <option value="georgia-tech" >Georgia Tech</option> <option value="gerstmann-straussler-scheinker-syndrome" >Gerstmann-Straussler-Scheinker syndrome</option> <option value="giant-axonal-neuropathy" >giant axonal neuropathy</option> <option value="giant-squid" >giant squid</option> <option value="gillian-belbin" >Gillian Belbin</option> <option value="gina" >GINA</option> <option value="ginkgo-biosciences" >Ginkgo Biosciences</option> <option value="gisaid" >GISAID</option> <option value="gleevec" >Gleevec</option> <option value="glenn-oneill" >Glenn O'Neill</option> <option value="glioma" >glioma</option> <option value="global-genes" >Global Genes</option> <option value="globalgenes" >GlobalGenes</option> <option value="glucagon" >glucagon</option> <option value="glutaric-aciduria" >glutaric aciduria</option> <option value="glybera" >Glybera</option> <option value="glyphosate" >glyphosate</option> <option value="gm-crops" >GM crops</option> <option value="gm-milk" >GM milk</option> <option value="gmo" >GMO</option> <option value="god-gene" >God gene</option> <option value="gorilla-genome" >gorilla genome</option> <option value="gosh" >GOSH</option> <option value="grace-science-foundation" >Grace Science Foundation</option> <option value="grail" >GRAIL</option> <option value="granular-corneal-dystrophy" >granular corneal dystrophy</option> <option value="gray-wolf" >gray wolf</option> <option value="greenland-dna" >Greenland DNA</option> <option value="gro" >GRO</option> <option value="guardian" >GUARDIAN</option> <option value="gum" >gum</option> <option value="gypsies" >gypsies</option> <option value="h1n1" >H1N1</option> <option value="h5n8" >H5N8</option> <option value="hair-follicle" >hair follicle</option> <option value="halo-therapeutics" >Halo Therapeutics</option> <option value="handmaids-tale" >Handmaid's Tale</option> <option value="hannah-sames" >Hannah Sames</option> <option value="hannahs-hope-fund" >Hannah's Hope Fund</option> <option value="haplarithmisis" >haplarithmisis</option> <option value="harnessinggrief" >Harnessinggrief</option> <option value="harvard-stem-cell-institute" >Harvard Stem Cell Institute</option> <option value="harvey-weinstein" >Harvey Weinstein</option> <option value="hawkins" >Hawkins</option> <option value="hayflick-limit" >Hayflick limit</option> <option value="hd" >HD</option> <option value="heart-attack" >heart attack</option> <option value="hemophilia" >hemophilia</option> <option value="hemophilia-a" >hemophilia A</option> <option value="hemophilia-b" >hemophilia B</option> <option value="henry-daniell" >Henry Daniell</option> <option value="hensel-twins" >Hensel twins</option> <option value="hepatitis-c" >hepatitis C</option> <option value="herceptin" >Herceptin</option> <option value="herd-immunity" >herd immunity</option> <option value="herd-immunity-threshold" >herd immunity threshold</option> <option value="hereditary-cancer" >hereditary cancer</option> <option value="hes-cells" >hES cells</option> <option value="heterogoneisis" >heterogoneisis</option> <option value="heterozygote-advantage" >heterozygote advantage</option> <option value="high-school-science" >high school science</option> <option value="hippo-dna" >hippo DNA</option> <option value="hirudin" >hirudin</option> <option value="history-of-genetics" >history of genetics</option> <option value="hiv" >HIV</option> <option value="homogentisic-acid" >homogentisic acid</option> <option value="honoree-fanonne-jeffers" >Honoree Fanonne Jeffers</option> <option value="horseracing" >horseracing</option> <option value="horsetalk-co-nz" >Horsetalk.co.nz</option> <option value="house-md" >House MD</option> <option value="howard-bauchner" >Howard Bauchner</option> <option value="htt" >HTT</option> <option value="htt-gene" >Htt gene</option> <option value="human-embryo" >human embryo</option> <option value="human-embryonic-stem-cells" >human embryonic stem cells</option> <option value="human-es-cells" >human ES cells</option> <option value="human-evolution" >human evolution</option> <option value="human-genetics-textbook" >human genetics textbook</option> <option value="human-genome" >human genome</option> <option value="human-genome-sequencing" >human genome sequencing</option> <option value="human-immunodeficiency-virus" >human immunodeficiency virus</option> <option value="human-longevity-inc" >Human Longevity Inc</option> <option value="human-pig-chimera" >human pig chimera</option> <option value="huntingtin" >huntingtin</option> <option value="huntington-disease" >Huntington disease</option> <option value="huntingtons-disease" >Huntington's disease</option> <option value="hutchinson-gilford-progeria-syndrome" >Hutchinson-Gilford progeria syndrome</option> <option value="hydractinia" >Hydractinia</option> <option value="hypertrichosis" >hypertrichosis</option> <option value="hypothetical-minimal-genome" >hypothetical minimal genome</option> <option value="iatrogenic" >iatrogenic</option> <option value="icahn-school-of-medicine" >Icahn School of Medicine</option> <option value="ice-bucket-challenge" >ice bucket challenge</option> <option value="il-17" >IL-17</option> <option value="ilana-glaser" >Ilana Glaser</option> <option value="immunitybio" >ImmunityBio</option> <option value="immunovative-therapies" >Immunovative Therapies</option> <option value="in-vitro-fertilization" >in vitro fertilization</option> <option value="inborn-error-of-metabolism" >inborn error of metabolism</option> <option value="induced-pluripotent-stem-cell" >induced pluripotent stem cell</option> <option value="induced-pluripotent-stem-cells" >induced pluripotent stem cells</option> <option value="inferno" >Inferno</option> <option value="infertility" >infertility</option> <option value="inflammation" >inflammation</option> <option value="influenza" >influenza</option> <option value="informed-consent" >informed consent</option> <option value="innate-immunity" >innate immunity</option> <option value="insect-farms" >insect farms</option> <option value="inside-the-obriens" >Inside the O'Briens</option> <option value="insulin" >insulin</option> <option value="intelligent-design" >intelligent design</option> <option value="intermediate-filaments" >intermediate filaments</option> <option value="international-summit-on-human-gene-editing" >International Summit on Human Gene Editing</option> <option value="intron" >intron</option> <option value="invasion" >Invasion</option> <option value="inversion" >inversion</option> <option value="invitae" >Invitae</option> <option value="ionis-pharmaceuticals" >Ionis Pharmaceuticals</option> <option value="ips-cells" >iPS cells</option> <option value="isis-pharmaceuticals" >Isis Pharmaceuticals</option> <option value="islet-homeostasis-protein" >islet homeostasis protein</option> <option value="j-craig-venter" >J. Craig Venter</option> <option value="jackson-lab" >Jackson lab</option> <option value="jacobs-syndrome" >Jacobs syndrome</option> <option value="jak1" >JAK1</option> <option value="jama" >JAMA</option> <option value="james-patterson" >James Patterson</option> <option value="james-watson" >James Watson</option> <option value="jcvi-syn3-0" >JCVI-syn3.0</option> <option value="jean-bennett" >Jean Bennett</option> <option value="jean-laurent-casanova" >Jean-Laurent Casanova</option> <option value="jennifer-doudna" >Jennifer Doudna</option> <option value="jerry-seinfeld" >Jerry Seinfeld</option> <option value="jesse-gelsinger" >Jesse Gelsinger</option> <option value="jhd" >JHD</option> <option value="john-belushi" >John Belushi</option> <option value="john-collinge" >John Collinge</option> <option value="john-zhang" >John Zhang</option> <option value="jonas-salk" >Jonas Salk</option> <option value="jono-lancaster" >Jono Lancaster</option> <option value="joshua-frase-foundation" >Joshua Frase Foundation</option> <option value="jurassic-park" >Jurassic Park</option> <option value="jurassic-parkdominion" >Jurassic Park:Dominion</option> <option value="jurassic-world" >Jurassic World</option> <option value="just-so-story" >just-so story</option> <option value="juvenile-huntington-disease" >juvenile Huntington disease</option> <option value="juvenile-huntingtons-disease" >juvenile Huntington's disease</option> <option value="kale" >kale</option> <option value="kalydeco" >Kalydeco</option> <option value="kary-mullis" >Kary Mullis</option> <option value="karyotype" >karyotype</option> <option value="katherine-high" >Katherine High</option> <option value="katla" >Katla</option> <option value="kellyanne-conway" >Kellyanne Conway</option> <option value="kevin-eggan" >Kevin Eggan</option> <option value="kevin-spacey" >Kevin Spacey</option> <option value="kin-selection" >kin selection</option> <option value="krestovka" >Krestovka</option> <option value="kristallnacht" >Kristallnacht</option> <option value="kristin-smedley" >Kristin Smedley</option> <option value="krystal-biotech" >Krystal Biotech</option> <option value="kuru" >kuru</option> <option value="lab-leak-theory" >lab leak theory</option> <option value="labradoodle" >labradoodle</option> <option value="lactose-intolerance" >lactose intolerance</option> <option value="lambda-variant" >lambda variant</option> <option value="lasik" >LASIK</option> <option value="laura-king-edwards" >Laura King Edwards</option> <option value="layla-richards" >Layla Richards</option> <option value="lca10" >LCA10</option> <option value="lca2" >LCA2</option> <option value="ldl" >LDL</option> <option value="leber-congenital-amaurosis" >Leber congenital amaurosis</option> <option value="leber-congenital-amaurosis-2" >Leber congenital amaurosis 2</option> <option value="leigh-syndrome" >Leigh syndrome</option> <option value="leigh-turner" >Leigh Turner</option> <option value="leonary-hayflick" >Leonary Hayflick</option> <option value="leptin" >leptin</option> <option value="leroy-stevens" >Leroy Stevens</option> <option value="leslie-gordon" >Leslie Gordon</option> <option value="leslie-lyons" >Leslie Lyons</option> <option value="lessons-in-chemistry" >Lessons in Chemistry</option> <option value="leukemia" >leukemia</option> <option value="lgbtq" >LGBTQ</option> <option value="lgbtqia" >LGBTQIA</option> <option value="lgpca" >LgPCA</option> <option value="liberia" >Liberia</option> <option value="linc-rna" >LINC RNA</option> <option value="lipofuscin" >lipofuscin</option> <option value="lipoprotein-lipase-deficiency" >lipoprotein lipase deficiency</option> <option value="liquid-biopsy" >liquid biopsy</option> <option value="lisa-genova" >Lisa Genova</option> <option value="little-bush-moa" >little bush moa</option> <option value="living-fossil" >living fossil</option> <option value="lobster-boy" >Lobster boy</option> <option value="lobster-claw-deformity" >lobster claw deformity</option> <option value="lonafarnib" >Lonafarnib</option> <option value="lonesome-george" >Lonesome George</option> <option value="longevity" >longevity</option> <option value="lorenzos-oil" >Lorenzo's Oil</option> <option value="lori-sames" >Lori Sames</option> <option value="lost-in-space" >Lost in Space</option> <option value="lou-gehrigs-disease" >Lou Gehrig's disease</option> <option value="lume" >Lume</option> <option value="lung-transplant" >lung transplant</option> <option value="luxturna" >Luxturna</option> <option value="luxurna" >Luxurna</option> <option value="lysogene" >Lysogene</option> <option value="lysosomal-storage-disease" >lysosomal storage disease</option> <option value="mab" >MAb</option> <option value="mad-cow-disease" >mad cow disease</option> <option value="mad-scientist" >mad scientist</option> <option value="mammalian-radiation" >mammalian radiation</option> <option value="mammals" >mammals</option> <option value="mammogram" >mammogram</option> <option value="mammography" >mammography</option> <option value="mammoth" >mammoth</option> <option value="mammoth-dna" >mammoth DNA</option> <option value="mandelic-acid" >mandelic acid</option> <option value="maoa" >MAOA</option> <option value="marfan-syndrome" >Marfan syndrome</option> <option value="margaret-atwood" >Margaret Atwood</option> <option value="maria-kefalas" >Maria Kefalas</option> <option value="mark-kieran" >Mark Kieran</option> <option value="marshfield-clinic-research-foundation" >Marshfield Clinic Research Foundation</option> <option value="marthas-vineyard" >Martha's Vineyard</option> <option value="mary-claire-king" >Mary-Claire King</option> <option value="mass-murderer" >mass murderer</option> <option value="masscpr" >MassCPR</option> <option value="match" >MATCH</option> <option value="maternal-age-effects" >maternal age effects</option> <option value="maui-fire" >Maui fire</option> <option value="max-randell" >Max Randell</option> <option value="mayer-rokitansky-kuster-hauser-syndrome" >Mayer-Rokitansky-Kuster-Hauser syndrome</option> <option value="mayra-martinez-lopez" >Mayra Martinez-Lopez</option> <option value="mc1r" >MC1R</option> <option value="mced" >MCED</option> <option value="md" >MD</option> <option value="mda" >MDA</option> <option value="measles" >measles</option> <option value="medical-chart" >medical chart</option> <option value="medrxiv" >medRxiv</option> <option value="melanocortin-1-receptor" >melanocortin-1 receptor</option> <option value="melanoma" >melanoma</option> <option value="mellow-yellow" >mellow yellow</option> <option value="meng-wang" >Meng Wang</option> <option value="menkes-disease" >Menkes disease</option> <option value="menopause-toolkit" >menopause toolkit</option> <option value="mers" >MERS</option> <option value="mesenchymal-stem-cell" >mesenchymal stem cell</option> <option value="mesolithic-chewing-gum" >Mesolithic chewing gum</option> <option value="metachromatic-leukodystrophy" >metachromatic leukodystrophy</option> <option value="metagenomics" >metagenomics</option> <option value="methemoglobinemia" >methemoglobinemia</option> <option value="michael-crichton" >Michael Crichton</option> <option value="michael-j-fox-foundation" >Michael J. Fox Foundation</option> <option value="michael-mina" >Michael Mina</option> <option value="michael-ransom" >Michael Ransom</option> <option value="michael-smedley" >Michael Smedley</option> <option value="microbiome" >microbiome</option> <option value="microcephaly" >microcephaly</option> <option value="microchimerism" >microchimerism</option> <option value="microevolution" >microevolution</option> <option value="microglia" >microglia</option> <option value="miscarriage" >miscarriage</option> <option value="mismatch-repair" >mismatch repair</option> <option value="misogyny" >misogyny</option> <option value="mitochondria" >mitochondria</option> <option value="mitochondrial-disease" >mitochondrial disease</option> <option value="mitochondrial-dna" >mitochondrial DNA</option> <option value="mitochondrial-dna-depletion-syndrome" >mitochondrial DNA depletion syndrome</option> <option value="mitochondrial-manipulation" >mitochondrial manipulation</option> <option value="mitochondrial-replacement-therapy" >mitochondrial replacement therapy</option> <option value="mld" >MLD</option> <option value="mmr" >MMR</option> <option value="moderna" >Moderna</option> <option value="monkeypox" >monkeypox</option> <option value="monoclonal-antibody" >monoclonal antibody</option> <option value="motor-neuron-disease" >motor neuron disease</option> <option value="mourning-gecko" >mourning gecko</option> <option value="mouse-studies" >mouse studies</option> <option value="mps" >MPS</option> <option value="mrkh" >MRKH</option> <option value="mrna" >mRNA</option> <option value="mrna-vaccine" >mRNA vaccine</option> <option value="msc" >MSC</option> <option value="msk-impact-tumor-profiling" >MSK-IMPACT Tumor Profiling</option> <option value="mskcc" >MSKCC</option> <option value="mtdna" >mtDNA</option> <option value="mtm" >MTM</option> <option value="mucopolysaccharidosis" >mucopolysaccharidosis</option> <option value="multi-cancer-early-detection-blood-test" >multi-cancer early detection blood test</option> <option value="multi-omic-data-repositories" >multi-omic data repositories</option> <option value="multiple-sulfatase-deficiency" >multiple sulfatase deficiency</option> <option value="mumps" >mumps</option> <option value="mutation" >mutation</option> <option value="mutation-significance-cutoff" >mutation significance cutoff</option> <option value="myalept" >Myalept</option> <option value="myotonic-dystrophy" >myotonic dystrophy</option> <option value="myotubular-myopathy" >myotubular myopathy</option> <option value="myriad-genetics" >Myriad Genetics</option> <option value="mz-twins" >MZ twins</option> <option value="n501y" >N501Y</option> <option value="nail-stem-cells" >nail stem cells</option> <option value="naomi-alderman" >Naomi Alderman</option> <option value="nasopharyngeal-swab" >nasopharyngeal swab</option> <option value="natera" >Natera</option> <option value="national-academy-of-sciences" >National Academy of Sciences</option> <option value="national-society-of-genetic-counselors" >National Society of Genetic Counselors</option> <option value="nationwide-childrens" >Nationwide Children's</option> <option value="nationwide-childrens-hospital" >Nationwide Children's Hospital</option> <option value="native-whole-body-deodorant" >Native whole body deodorant</option> <option value="natural-selection" >natural selection</option> <option value="nature" >Nature</option> <option value="nature-communications" >Nature Communications</option> <option value="nature-food" >Nature Food</option> <option value="navigenics" >Navigenics</option> <option value="nazi" >Nazi</option> <option value="neanderthal" >Neanderthal</option> <option value="neanderthal-tartar" >Neanderthal tartar</option> <option value="neanderthals" >Neanderthals</option> <option value="neovagina" >neovagina</option> <option value="netflix" >Netflix</option> <option value="neu5gc" >Neu5Gc</option> <option value="neural-stem-cells" >neural stem cells</option> <option value="neural-tube-defect" >neural tube defect</option> <option value="neurofibromatosis" >neurofibromatosis</option> <option value="neuronal-ceroid-lipofuscinosis" >neuronal ceroid lipofuscinosis</option> <option value="neuropathy" >neuropathy</option> <option value="new-antibiotics" >new antibiotics</option> <option value="new-blog" >new blog</option> <option value="new-fungus" >new fungus</option> <option value="new-human-species" >new human species</option> <option value="newborn-genome-sequencing" >newborn genome sequencing</option> <option value="newborn-screening" >newborn screening</option> <option value="newtown-connecticut" >Newtown Connecticut</option> <option value="nextcode-health" >NextCODE Health</option> <option value="ngly1-deficiency" >NGLY1 deficiency</option> <option value="nhgri" >NHGRI</option> <option value="nida" >NIDA</option> <option value="niemann-pick" >Niemann-Pick</option> <option value="nih" >NIH</option> <option value="nips" >NIPS</option> <option value="nipt" >NIPT</option> <option value="nitisinone" >nitisinone</option> <option value="nobel-prize" >Nobel Prize</option> <option value="non-a-e-hepatitis" >non-A-E hepatitis</option> <option value="non-invasive-prenatal-testing" >non-invasive prenatal testing</option> <option value="nord" >NORD</option> <option value="norovirus" >norovirus</option> <option value="nose-picking" >nose-picking</option> <option value="novelna" >Novelna</option> <option value="npe" >NPE</option> <option value="nsgc" >NSGC</option> <option value="nucleic-acid-therapeutics" >Nucleic Acid Therapeutics</option> <option value="nucleolus" >nucleolus</option> <option value="nutragenetics" >nutragenetics</option> <option value="obese-mice" >obese mice</option> <option value="occupational-therapy" >occupational therapy</option> <option value="ochratoxin" >ochratoxin</option> <option value="octopus" >octopus</option> <option value="oi" >OI</option> <option value="oif" >OIF</option> <option value="omicron" >Omicron</option> <option value="omicron-variant" >omicron variant</option> <option value="on-call" >On Call</option> <option value="oncology" >oncology</option> <option value="one-health" >One Health</option> <option value="opdivo" >Opdivo</option> <option value="ophthalmology" >ophthalmology</option> <option value="opiates" >opiates</option> <option value="orchard-therapeutics" >Orchard Therapeutics</option> <option value="ordinary-soil" >Ordinary Soil</option> <option value="orfadin" >Orfadin</option> <option value="organex" >OrganEx</option> <option value="organogenesis" >organogenesis</option> <option value="organoid" >organoid</option> <option value="organoids" >organoids</option> <option value="osteogenesis-imperfecta" >osteogenesis imperfecta</option> <option value="otzi" >Otzi</option> <option value="our-father" >Our Father</option> <option value="ovary" >ovary</option> <option value="pain" >pain</option> <option value="paleogenomics" >paleogenomics</option> <option value="palynziq" >Palynziq</option> <option value="pancov" >panCoV</option> <option value="pandemic" >pandemic</option> <option value="pandemic-of-2020" >pandemic of 2020</option> <option value="pangenome" >pangenome</option> <option value="pangenomics" >pangenomics</option> <option value="pangolin" >pangolin</option> <option value="paola-leone" >Paola Leone</option> <option value="pap-smear" >Pap smear</option> <option value="papau-new-guinea" >Papau New Guinea</option> <option value="parkinsons-disease" >Parkinson's disease</option> <option value="paul-offit" >Paul Offit</option> <option value="paul-offitt" >Paul Offitt</option> <option value="paulas-choice" >Paula's Choice</option> <option value="pawan-sinha" >Pawan Sinha</option> <option value="pcr" >PCR</option> <option value="penn" >Penn</option> <option value="personalized-medicine" >personalized medicine</option> <option value="pfizer-vaccine" >Pfizer vaccine</option> <option value="phacilitate" >Phacilitate</option> <option value="pharmacogenetics" >pharmacogenetics</option> <option value="phd" >PhD</option> <option value="phenylketonuris" >phenylketonuris</option> <option value="pheromone" >pheromone</option> <option value="photoreceptors" >photoreceptors</option> <option value="physical-therapy" >physical therapy</option> <option value="pigman" >pigman</option> <option value="pku" >PKU</option> <option value="placenta" >placenta</option> <option value="placental-mammal" >placental mammal</option> <option value="plague" >plague</option> <option value="planned-parenthood" >Planned Parenthood</option> <option value="plos-biology" >PLOS Biology</option> <option value="plos-blogs-network" >PLOS Blogs Network</option> <option value="plos-one" >PLoS One</option> <option value="pocahontas" >Pocahontas</option> <option value="polar-body-biopsy" >polar body biopsy</option> <option value="polar-body-testing" >polar body testing</option> <option value="polio" >polio</option> <option value="polygenic-risk-score" >polygenic risk score</option> <option value="polymerase-chain-reaction" >polymerase chain reaction</option> <option value="porphyria" >porphyria</option> <option value="post-election-health-effects" >post-election health effects</option> <option value="prader-willi-syndrome" >Prader-Willi Syndrome</option> <option value="precision-medicine" >precision medicine</option> <option value="precision-medicine-initiative" >Precision Medicine Initiative</option> <option value="precision-medicine-initiative-cohort-program" >Precision Medicine Initiative Cohort Program</option> <option value="pregnancy-loss" >pregnancy loss</option> <option value="preimplantation-genetic-diagnosis" >preimplantation genetic diagnosis</option> <option value="prenatal-diagnosis" >prenatal diagnosis</option> <option value="prenatal-genetic-testing" >prenatal genetic testing</option> <option value="prenatal-testing" >prenatal testing</option> <option value="president-obama" >President Obama</option> <option value="pretty-lake" >Pretty Lake</option> <option value="prevagen" >Prevagen</option> <option value="prion" >prion</option> <option value="prions" >prions</option> <option value="production-line-hypothesis" >production line hypothesis</option> <option value="progeria" >progeria</option> <option value="progeria-research-foundation" >Progeria Research Foundation</option> <option value="project-prakash" >Project Prakash</option> <option value="pronuclear-transfer" >pronuclear transfer</option> <option value="proteasome" >proteasome</option> <option value="protein-folding" >protein folding</option> <option value="proteomics" >proteomics</option> <option value="prs" >PRS</option> <option value="psen1-e280a" >PSEN1 E280A</option> <option value="pulmonary-embolism" >pulmonary embolism</option> <option value="pumpkin" >pumpkin</option> <option value="pyloric-stenosis" >pyloric stenosis</option> <option value="q-fever" >Q Fever</option> <option value="rabbit" >rabbit</option> <option value="race-based-medicine" >race-based medicine</option> <option value="race-based-prescribing" >race-based prescribing</option> <option value="rainbow" >rainbow</option> <option value="rapid-antigen-test" >rapid antigen test</option> <option value="rare" >rare</option> <option value="rare-disease" >rare disease</option> <option value="rare-disease-day" >Rare Disease Day</option> <option value="rare-disease-day-2015" >Rare Disease Day 2015</option> <option value="rare-disease-day-2020" >Rare Disease Day 2020</option> <option value="rare-disease-day-2022" >Rare Disease Day 2022</option> <option value="rare-disease-day-2023" >Rare Disease Day 2023</option> <option value="rare-diseases" >rare diseases</option> <option value="raredisease" >raredisease</option> <option value="rarediseaseday" >RareDiseaseDay</option> <option value="ratg13" >RaTG13</option> <option value="rdh12" >RDH12</option> <option value="rdna" >rDNA</option> <option value="rdr" >RDR</option> <option value="red-wolf" >red wolf</option> <option value="reelin" >reelin</option> <option value="regeneration" >regeneration</option> <option value="regenerative-medicine" >regenerative medicine</option> <option value="regeneron" >Regeneron</option> <option value="rejuvenation-research" >Rejuvenation Research</option> <option value="religion-gene" >religion gene</option> <option value="religiosity" >religiosity</option> <option value="remdesivir" >Remdesivir</option> <option value="reopening-economy" >reopening economy</option> <option value="reprogrammed-cells" >reprogrammed cells</option> <option value="retina" >retina</option> <option value="retinal-pigment-epithelium" >retinal pigment epithelium</option> <option value="retinitis-pigmentosa" >retinitis pigmentosa</option> <option value="retinoblastoma" >retinoblastoma</option> <option value="retinoschisis" >retinoschisis</option> <option value="rett-syndrome" >Rett Syndrome</option> <option value="revive-restore" >Revive & Restore</option> <option value="revive-and-restore" >Revive and Restore</option> <option value="ribosomal-dna" >ribosomal DNA</option> <option value="richard-o-prum" >Richard O. Prum</option> <option value="ricki-lewis" >Ricki Lewis</option> <option value="right-to-die" >right-to-die</option> <option value="rita-fior" >Rita Fior</option> <option value="rna" >RNA</option> <option value="rna-editing" >RNA editing</option> <option value="rna-tie-club" >RNA Tie Club</option> <option value="rna-seq" >RNA-Seq</option> <option value="rnai" >RNAi</option> <option value="robert-f-kennedy-jr" >Robert F. Kennedy Jr.</option> <option value="robert-langdon" >Robert Langdon</option> <option value="robert-marion-md" >Robert Marion MD</option> <option value="robertsonian-translocation" >Robertsonian translocation</option> <option value="roe-v-wade" >Roe v Wade</option> <option value="roma" >Roma</option> <option value="romani" >Romani</option> <option value="romulans" >Romulans</option> <option value="ron-howard" >Ron Howard</option> <option value="rosemarys-baby" >Rosemary's Baby</option> <option value="roundup" >roundup</option> <option value="rp" >RP</option> <option value="rpe" >RPE</option> <option value="rpe65" >RPE65</option> <option value="rpe65-mediated-inherited-retinal-dystrophy" >RPE65-mediated inherited retinal dystrophy</option> <option value="rrm2b" >RRM2B</option> <option value="rubella" >rubella</option> <option value="run-to-the-light" >Run to the Light</option> <option value="rusp" >RUSP</option> <option value="ryan-dant" >Ryan Dant</option> <option value="saffron" >saffron</option> <option value="salvation" >Salvation</option> <option value="same-sex-sexual-behavior" >same-sex sexual behavior</option> <option value="san-diego-frozen-zoo" >San Diego Frozen Zoo</option> <option value="sanfilippo" >Sanfilippo</option> <option value="sanfilippo-syndrome" >Sanfilippo syndrome</option> <option value="sanfilippo-syndrome-a" >Sanfilippo syndrome A</option> <option value="sapiens" >Sapiens</option> <option value="sarah-soden" >Sarah Soden</option> <option value="sars" >SARS</option> <option value="sars-cov-2" >SARS-CoV-2</option> <option value="saving-eliza" >Saving Eliza</option> <option value="scaly-anteater" >scaly anteater</option> <option value="schizophrenia" >schizophrenia</option> <option value="schneider-childrens-medical-center" >Schneider Children's Medical Center</option> <option value="sci-fi" >sci fi</option> <option value="scid-ada" >SCID-ADA</option> <option value="scid-x1" >SCID-X1</option> <option value="science" >Science</option> <option value="science-and-reason-matter" >science and reason matter</option> <option value="science-fair" >science fair</option> <option value="science-fiction" >science fiction</option> <option value="science-literacy" >science literacy</option> <option value="scleroderma" >scleroderma</option> <option value="scn9a" >SCN9A</option> <option value="sea-of-tranquility" >Sea of Tranquility</option> <option value="sean-spicer" >Sean Spicer</option> <option value="seizures" >seizures</option> <option value="settled-science" >settled science</option> <option value="seveneves" >SevenEves</option> <option value="sexism" >sexism</option> <option value="sexual-selection" >sexual selection</option> <option value="sexual-stereotyping" >sexual stereotyping</option> <option value="sharon-king" >Sharon King</option> <option value="short-tandem-repeat" >short tandem repeat</option> <option value="sialic-acid" >sialic acid</option> <option value="sickle-cell-disease" >sickle cell disease</option> <option value="signal-transduction" >signal transduction</option> <option value="single-cell-transcriptomics" >single-cell transcriptomics</option> <option value="sirna" >siRNA</option> <option value="siv" >SIV</option> <option value="skin-color" >skin color</option> <option value="skysona" >Skysona</option> <option value="sma" >SMA</option> <option value="small-molecules" >small molecules</option> <option value="smallpox" >smallpox</option> <option value="snot" >snot</option> <option value="snp-microarrays" >SNP microarrays</option> <option value="sodium-channel" >sodium channel</option> <option value="solve-rd" >Solve-RD</option> <option value="south-beach-diet" >South Beach diet</option> <option value="sox9" >Sox9</option> <option value="space-aliens" >space aliens</option> <option value="spark-therapeutics" >Spark Therapeutics</option> <option value="spatial-transcriptomics" >spatial transcriptomics</option> <option value="sperm-donor" >sperm donor</option> <option value="spinach-genome" >spinach genome</option> <option value="spinal-muscular-atrophy" >spinal muscular atrophy</option> <option value="spinal-muscular-atrophy-foundation" >Spinal Muscular Atrophy Foundation</option> <option value="spinraza" >Spinraza</option> <option value="split-hand-foot" >split-hand/foot</option> <option value="sports-gene" >sports gene</option> <option value="squash" >squash</option> <option value="squid" >squid</option> <option value="star-trek" >Star Trek</option> <option value="star-wars" >Star Wars</option> <option value="statins" >statins</option> <option value="station-eleven" >Station Eleven</option> <option value="steel-syndrome" >Steel syndrome</option> <option value="stefan-moritz" >Stefan Moritz</option> <option value="stem-cell-therapy" >stem cell therapy</option> <option value="stem-cell-tourism" >stem cell tourism</option> <option value="stem-cells" >stem cells</option> <option value="stephen-kaler" >Stephen Kaler</option> <option value="steve-fialkoff" >Steve Fialkoff</option> <option value="steven-gray" >Steven Gray</option> <option value="still-alice" >Still Alice</option> <option value="stone-age-chewing-gum" >stone age chewing gum</option> <option value="stranger-things" >Stranger Things</option> <option value="stress" >stress</option> <option value="strimvelis" >Strimvelis</option> <option value="sulcata" >sulcata</option> <option value="sumatran-rhinoceros" >Sumatran rhinoceros</option> <option value="summer-sci-fi" >summer sci fi</option> <option value="sunburn" >sunburn</option> <option value="sunscreen" >sunscreen</option> <option value="supercentenarian" >supercentenarian</option> <option value="survival-of-the-fittest" >survival of the fittest</option> <option value="svante-paabo" >Svante Pääbo</option> <option value="synthetic-biology" >synthetic biology</option> <option value="systemic-sclerosis" >systemic sclerosis</option> <option value="t-cell" >T cell</option> <option value="t-h-chan-school-of-public-health" >T.H. Chan School of Public Health</option> <option value="tabby" >tabby</option> <option value="tabby-cat" >tabby cat</option> <option value="tafamidis" >Tafamidis</option> <option value="taillessness" >taillessness</option> <option value="talen" >TALEN</option> <option value="tanning" >tanning</option> <option value="tardigrade" >tardigrade</option> <option value="targeted-cancer-drugs" >targeted cancer drugs</option> <option value="targeted-drug" >targeted drug</option> <option value="targeted-drugs" >targeted drugs</option> <option value="tasmanian-devil" >Tasmanian devil</option> <option value="taylor-king" >Taylor King</option> <option value="tb" >TB</option> <option value="tbxt" >TBXT</option> <option value="telomere" >telomere</option> <option value="telomeres" >telomeres</option> <option value="tenebrio-molitor" >Tenebrio molitor</option> <option value="teratoma" >teratoma</option> <option value="tgen" >TGen</option> <option value="thanksgiving" >Thanksgiving</option> <option value="thanksgiving-squash-recipes" >Thanksgiving squash recipes</option> <option value="the-boss" >The Boss</option> <option value="the-cancer-genome-atlas" >The Cancer Genome Atlas</option> <option value="the-clinic-for-special-children" >The Clinic for Special Children</option> <option value="the-covenant-of-water" >The Covenant of Water</option> <option value="the-egg" >The Egg</option> <option value="the-festival-of-genomics-and-biodata" >The Festival of Genomics and Biodata</option> <option value="the-forever-fix" >The Forever Fix</option> <option value="the-last-of-us" >The Last of Us</option> <option value="the-leftovers" >The Leftovers</option> <option value="the-lions-mouth-opens" >The Lion's Mouth Opens</option> <option value="the-power" >The Power</option> <option value="the-ripper-gene" >The Ripper Gene</option> <option value="the-tomorrow-war" >The Tomorrow War</option> <option value="the-trump-10" >the Trump 10</option> <option value="the-vanishing-half" >The Vanishing Half</option> <option value="thomas-hunt-morgan" >Thomas Hunt Morgan</option> <option value="thomas-lozito" >Thomas Lozito</option> <option value="three-identical-strangers" >Three Identical Strangers</option> <option value="thyroid" >thyroid</option> <option value="thyroid-cancer" >thyroid cancer</option> <option value="time-travel" >time travel</option> <option value="tishkoff" >Tishkoff</option> <option value="tissue-engineering" >tissue engineering</option> <option value="tmau" >TMAU</option> <option value="tofacitinib" >tofacitinib</option> <option value="tom-hanks" >Tom Hanks</option> <option value="tortoise" >tortoise</option> <option value="toxic-knowledge" >toxic knowledge</option> <option value="tozinameran" >Tozinameran</option> <option value="transcriptome" >transcriptome</option> <option value="transcriptomic-atlas" >transcriptomic atlas</option> <option value="transgender" >transgender</option> <option value="transgender-and-genetics" >transgender and genetics</option> <option value="transgender-identities" >transgender identities</option> <option value="translocation" >translocation</option> <option value="treacher-collins-syndrome" >Treacher Collins syndrome</option> <option value="treatabolome" >Treatabolome</option> <option value="tredparse" >TREDPARSE</option> <option value="triglycerides" >triglycerides</option> <option value="trisomy-21" >trisomy 21</option> <option value="trophoblast" >trophoblast</option> <option value="trsp1" >Trsp1</option> <option value="trump" >Trump</option> <option value="trump-effect" >Trump effect</option> <option value="ttr-amyloidosis" >TTR amyloidosis</option> <option value="tuberculosis" >tuberculosis</option> <option value="tumor-suppressor" >tumor suppressor</option> <option value="tumornext" >TumorNext</option> <option value="turkey-genetics" >turkey genetics</option> <option value="turkey-genome" >turkey genome</option> <option value="twilight-zone-project" >Twilight Zone Project</option> <option value="twin-studies" >twin studies</option> <option value="twins" >twins</option> <option value="two-americas" >Two Americas</option> <option value="type-1-diabetes" >type 1 diabetes</option> <option value="uk-dementia-research-institute" >UK Dementia Research Institute</option> <option value="uk-variant" >UK variant</option> <option value="under-the-dome" >Under the Dome</option> <option value="undiagnosed-disease-network" >undiagnosed disease network</option> <option value="uniqure" >UniQure</option> <option value="universal-vaccine" >universal vaccine</option> <option value="uroamp" >UroAmp</option> <option value="urothelial-cancer" >urothelial cancer</option> <option value="usher-2a" >Usher 2A</option> <option value="uv-damage" >UV damage</option> <option value="uveal-melanoma" >uveal melanoma</option> <option value="vaccination" >vaccination</option> <option value="vaccine" >vaccine</option> <option value="vaccine-enhancement-of-disease" >vaccine enhancement of disease</option> <option value="vaccine-hesitancy" >vaccine hesitancy</option> <option value="vaccines" >vaccines</option> <option value="vagina" >vagina</option> <option value="variants" >variants</option> <option value="vascular-dementia" >vascular dementia</option> <option value="vectored-contraception" >vectored contraception</option> <option value="vegetarian" >vegetarian</option> <option value="venous-thromboembolism-in-african-americans" >venous thromboembolism in African Americans</option> <option value="vertex-pharmaceuticals" >Vertex Pharmaceuticals</option> <option value="vestibular-schwannomatosis" >vestibular schwannomatosis</option> <option value="viagen-equine" >Viagen Equine</option> <option value="viltepso" >Viltepso</option> <option value="viral-vector" >viral vector</option> <option value="vus" >VUS</option> <option value="vyjuvek" >Vyjuvek</option> <option value="vyondys" >Vyondys</option> <option value="walt-spitzmiller" >Walt Spitzmiller</option> <option value="water-bear" >water bear</option> <option value="watermelon" >watermelon</option> <option value="watson-and-crick" >Watson and Crick</option> <option value="wayward-pines" >Wayward Pines</option> <option value="wayward-pines-finale" >Wayward Pines finale</option> <option value="weight-loss-surgery" >weight loss surgery</option> <option value="werewolves" >werewolves</option> <option value="wet-market" >wet market</option> <option value="white-nationalism" >white nationalism</option> <option value="white-supremacy" >white supremacy</option> <option value="who" >WHO</option> <option value="whoi" >WHOI</option> <option value="whole-body-deodorant" >whole body deodorant</option> <option value="wild-horses" >wild horses</option> <option value="wild-type" >wild type</option> <option value="willow-cannan" >Willow Cannan</option> <option value="wilson-disease" >Wilson disease</option> <option value="wishbone-day" >Wishbone Day</option> <option value="wmht-health-line" >WMHT HEALTH LINE</option> <option value="wolf-coyote-hybrid" >wolf-coyote hybrid</option> <option value="woman-card" >woman card</option> <option value="women-in-science" >women in science</option> <option value="woods-hole-oceanographic-institution" >Woods Hole Oceanographic Institution</option> <option value="woody-allen" >Woody Allen</option> <option value="woolly-rhino" >woolly rhino</option> <option value="world-malaria-day" >World Malaria Day</option> <option value="wuhan-coronavirus" >Wuhan coronavirus</option> <option value="x-inactivation" >X inactivation</option> <option value="x-files" >X-Files</option> <option value="xeljanz" >Xeljanz</option> <option value="xenotransplant" >xenotransplant</option> <option value="xxy" >XXY</option> <option value="xyy" >XYY</option> <option value="y-chromosome" >Y chromosome</option> <option value="yan-report" >Yan report</option> <option value="yellow-mealworm" >yellow mealworm</option> <option value="yervoy" >Yervoy</option> <option value="zavatar" >zAvatar</option> <option value="zelboraf" >Zelboraf</option> <option value="zinc-finger" >zinc finger</option> <option value="zolgensma" >Zolgensma</option> <option value="zoo-dna" >zoo DNA</option> <option value="zoonosis" >zoonosis</option> <option value="zynteglo" >Zynteglo</option> </select> </div> <div class="archive-filters__submit-container"> <input type="submit" value="Go" /> </div> <div class="archive-filters__view-controls"> <span class="archive-filters__view-label">View Style</span> <ul> <li><a class="archive-filters__view-control archive-filters__view-control--grid" data-style="grid">Grid view</a></li> <li><a class="archive-filters__view-control archive-filters__view-control--list archive-filters__view-control--active" data-style="list">List view</a></li> </ul> </div> </div> <div class="archive-filters__rss"> <span class="archive-filters__rss-label">Follow this Blog</span> <br /> <a class="archive-filters__rss-link" href="https://dnascience.plos.org/feed/"><i class="fas fa-rss"></i> RSS</a> </div> </fieldset> </form> <ul class="post-list post-list--list post-list--non-elementor" id="posts"> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://dnascience.plos.org/2024/11/14/a-genetic-crystal-ball-when-newborn-genome-sequencing-findings-explain-illnesses-in-relatives/" style="background-image: url(https://dnascience.plos.org/wp-content/uploads/sites/12/2014/01/newborn-screening.jpg);" title="A Genetic Crystal Ball: When Newborn Genome Sequencing Findings Explain Illnesses in Relatives"></a> <div class="post-list__post-text"> <span class="post-list__post-label">post</span> <span class="post-list__post-title"> <a href="https://dnascience.plos.org/2024/11/14/a-genetic-crystal-ball-when-newborn-genome-sequencing-findings-explain-illnesses-in-relatives/">A Genetic Crystal Ball: When Newborn Genome Sequencing Findings Explain Illnesses in Relatives</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">November 14, 2024</span> <span class="post-list__post-author">By <a href="https://dnascience.plos.org/author/rlewis/">Ricki Lewis, PhD</a></span> </div> <div class="post-list__post-excerpt"> <p>In 2019, I wrote about how sequencing the genomes of newborns might compromise their privacy if genetic information was not adequately protected…</p> </div> <a class="post-list__post-read-more" href="https://dnascience.plos.org/2024/11/14/a-genetic-crystal-ball-when-newborn-genome-sequencing-findings-explain-illnesses-in-relatives/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://dnascience.plos.org/2024/10/24/the-dangers-of-do-your-own-research-and-believe-in-science/" style="background-image: url(https://dnascience.plos.org/wp-content/uploads/sites/12/2024/10/Science_doesnt_care_what_you_believe_-_Melbourne_-MarchforScience_on_-Earthday_34167585396.jpg);" title="The Dangers of “Do Your Own Research” and “Believe in Science”"></a> <div class="post-list__post-text"> <span class="post-list__post-label">post</span> <span class="post-list__post-title"> <a href="https://dnascience.plos.org/2024/10/24/the-dangers-of-do-your-own-research-and-believe-in-science/">The Dangers of “Do Your Own Research” and “Believe in Science”</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 24, 2024</span> <span class="post-list__post-author">By <a href="https://dnascience.plos.org/author/rlewis/">Ricki Lewis, PhD</a></span> </div> <div class="post-list__post-excerpt"> <p>During the pandemic, we turned to our leaders for updates on the rapidly worsening, unprecedented situation. As days turned to weeks, and…</p> </div> <a class="post-list__post-read-more" href="https://dnascience.plos.org/2024/10/24/the-dangers-of-do-your-own-research-and-believe-in-science/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://dnascience.plos.org/2024/10/17/new-drug-miplyffa-approved-for-rare-niemann-pick-disease-type-3/" style="background-image: url(https://dnascience.plos.org/wp-content/uploads/sites/12/2024/10/Neuro-anatomy.jpg);" title="New Drug Miplyffa Approved for Rare Niemann-Pick Disease Type 3"></a> <div class="post-list__post-text"> <span class="post-list__post-label">post</span> <span class="post-list__post-title"> <a href="https://dnascience.plos.org/2024/10/17/new-drug-miplyffa-approved-for-rare-niemann-pick-disease-type-3/">New Drug Miplyffa Approved for Rare Niemann-Pick Disease Type 3</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 17, 2024</span> <span class="post-list__post-author">By <a href="https://dnascience.plos.org/author/rlewis/">Ricki Lewis, PhD</a></span> </div> <div class="post-list__post-excerpt"> <p>October is Niemann-Pick Awareness Month. FDA approved a treatment for type 3 of the ultra-rare genetic disease September 20. The quest has…</p> </div> <a class="post-list__post-read-more" href="https://dnascience.plos.org/2024/10/17/new-drug-miplyffa-approved-for-rare-niemann-pick-disease-type-3/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://dnascience.plos.org/2024/10/03/how-the-classic-tb-vaccine-treats-bladder-cancer-zebrafish-avatars-reveal-mechanism/" style="background-image: url(https://dnascience.plos.org/wp-content/uploads/sites/12/2024/10/Low-Res_still-tumor-red-macs-green.jpg);" title="How the Classic TB Vaccine Treats Bladder Cancer – Zebrafish Avatars Reveal Mechanism"></a> <div class="post-list__post-text"> <span class="post-list__post-label">post</span> <span class="post-list__post-title"> <a href="https://dnascience.plos.org/2024/10/03/how-the-classic-tb-vaccine-treats-bladder-cancer-zebrafish-avatars-reveal-mechanism/">How the Classic TB Vaccine Treats Bladder Cancer – Zebrafish Avatars Reveal Mechanism</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">October 3, 2024</span> <span class="post-list__post-author">By <a href="https://dnascience.plos.org/author/rlewis/">Ricki Lewis, PhD</a></span> </div> <div class="post-list__post-excerpt"> <p>Thanks to biotechnology, immunotherapy has become standard of care along many a cancer patient’s journey, with many targeted drugs now available. One…</p> </div> <a class="post-list__post-read-more" href="https://dnascience.plos.org/2024/10/03/how-the-classic-tb-vaccine-treats-bladder-cancer-zebrafish-avatars-reveal-mechanism/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://dnascience.plos.org/2024/09/19/genome-sequence-of-the-little-bush-moa-illuminates-avian-evolution/" style="background-image: url(https://dnascience.plos.org/wp-content/uploads/sites/12/2024/09/birds.jpg);" title="Genome Sequence of the Little Bush Moa Illuminates Avian Evolution"></a> <div class="post-list__post-text"> <span class="post-list__post-label">post</span> <span class="post-list__post-title"> <a href="https://dnascience.plos.org/2024/09/19/genome-sequence-of-the-little-bush-moa-illuminates-avian-evolution/">Genome Sequence of the Little Bush Moa Illuminates Avian Evolution</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">September 19, 2024</span> <span class="post-list__post-author">By <a href="https://dnascience.plos.org/author/rlewis/">Ricki Lewis, PhD</a></span> </div> <div class="post-list__post-excerpt"> <p>Since discovering my first fossils in a stream behind the Baseball Hall of Fame in Cooperstown, New York, when I was 10…</p> </div> <a class="post-list__post-read-more" href="https://dnascience.plos.org/2024/09/19/genome-sequence-of-the-little-bush-moa-illuminates-avian-evolution/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://dnascience.plos.org/2024/09/05/ai-tool-chief-paints-a-landscape-of-a-cancer-refining-diagnosis-treatment-and-prognosis/" style="background-image: url(https://dnascience.plos.org/wp-content/uploads/sites/12/2024/09/Breast_cancer_cell_1.jpg);" title="AI Tool CHIEF Paints a Landscape of a Cancer, Refining Diagnosis, Treatment, and Prognosis"></a> <div class="post-list__post-text"> <span class="post-list__post-label">post</span> <span class="post-list__post-title"> <a href="https://dnascience.plos.org/2024/09/05/ai-tool-chief-paints-a-landscape-of-a-cancer-refining-diagnosis-treatment-and-prognosis/">AI Tool CHIEF Paints a Landscape of a Cancer, Refining Diagnosis, Treatment, and Prognosis</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">September 5, 2024</span> <span class="post-list__post-author">By <a href="https://dnascience.plos.org/author/rlewis/">Ricki Lewis, PhD</a></span> </div> <div class="post-list__post-excerpt"> <p>A diagnosis of stage IV cancer used to mark the beginning of the end. Today for many patients, it is the beginning…</p> </div> <a class="post-list__post-read-more" href="https://dnascience.plos.org/2024/09/05/ai-tool-chief-paints-a-landscape-of-a-cancer-refining-diagnosis-treatment-and-prognosis/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://dnascience.plos.org/2024/08/22/michael-crichton-and-james-pattersons-eruption-is-riveting-but-with-a-shaky-genetic-foundation/" style="background-image: url(https://dnascience.plos.org/wp-content/uploads/sites/12/2024/08/Erupting_vents_on_Mauna_Loa_during_the_1984_eruption_ba440a24-2eec-4d85-ae08-f38115246835.jpg);" title="Michael Crichton and James Patterson’s “Eruption” is Riveting, but with a Shaky Genetic Foundation"></a> <div class="post-list__post-text"> <span class="post-list__post-label">post</span> <span class="post-list__post-title"> <a href="https://dnascience.plos.org/2024/08/22/michael-crichton-and-james-pattersons-eruption-is-riveting-but-with-a-shaky-genetic-foundation/">Michael Crichton and James Patterson’s “Eruption” is Riveting, but with a Shaky Genetic Foundation</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">August 22, 2024</span> <span class="post-list__post-author">By <a href="https://dnascience.plos.org/author/rlewis/">Ricki Lewis, PhD</a></span> </div> <div class="post-list__post-excerpt"> <p>I eagerly awaited publication of the novel Eruption, the brainchild of the late, great Michael Crichton and James Patterson, a master storyteller…</p> </div> <a class="post-list__post-read-more" href="https://dnascience.plos.org/2024/08/22/michael-crichton-and-james-pattersons-eruption-is-riveting-but-with-a-shaky-genetic-foundation/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://dnascience.plos.org/2024/08/08/an-unsilencer-drug-may-treat-angelman-syndrome-someday/" style="background-image: url(https://dnascience.plos.org/wp-content/uploads/sites/12/2024/08/Happy_Puppet_Syndrome_4.jpg);" title="An “Unsilencer” Drug May Treat Angelman Syndrome – Someday"></a> <div class="post-list__post-text"> <span class="post-list__post-label">post</span> <span class="post-list__post-title"> <a href="https://dnascience.plos.org/2024/08/08/an-unsilencer-drug-may-treat-angelman-syndrome-someday/">An “Unsilencer” Drug May Treat Angelman Syndrome – Someday</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">August 8, 2024</span> <span class="post-list__post-author">By <a href="https://dnascience.plos.org/author/rlewis/">Ricki Lewis, PhD</a></span> </div> <div class="post-list__post-excerpt"> <p>Angelman and Prader-Willi syndromes are intriguing related conditions. Each arises from missing the same small section of chromosome 15, but one develops…</p> </div> <a class="post-list__post-read-more" href="https://dnascience.plos.org/2024/08/08/an-unsilencer-drug-may-treat-angelman-syndrome-someday/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://dnascience.plos.org/2024/07/25/anthony-faucis-memoir-on-call-journeys-through-a-half-century-of-plagues-amid-the-politics-of-public-health/" style="background-image: url(https://dnascience.plos.org/wp-content/uploads/sites/12/2020/03/fauci-advisory-council.jpg);" title="Anthony Fauci’s Memoir “On Call” Journeys through a Half Century of Plagues Amid the Politics of Public Health"></a> <div class="post-list__post-text"> <span class="post-list__post-label">post</span> <span class="post-list__post-title"> <a href="https://dnascience.plos.org/2024/07/25/anthony-faucis-memoir-on-call-journeys-through-a-half-century-of-plagues-amid-the-politics-of-public-health/">Anthony Fauci’s Memoir “On Call” Journeys through a Half Century of Plagues Amid the Politics of Public Health</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">July 25, 2024</span> <span class="post-list__post-author">By <a href="https://dnascience.plos.org/author/rlewis/">Ricki Lewis, PhD</a></span> </div> <div class="post-list__post-excerpt"> <p>On Call, Dr. Anthony Fauci’s memoir, is a riveting read that ricochets through infectious disease challenges since the early 1980s. It concludes…</p> </div> <a class="post-list__post-read-more" href="https://dnascience.plos.org/2024/07/25/anthony-faucis-memoir-on-call-journeys-through-a-half-century-of-plagues-amid-the-politics-of-public-health/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://dnascience.plos.org/2024/07/11/extinction-echoes-jurassic-park-with-a-pleistocene-backdrop/" style="background-image: url(https://dnascience.plos.org/wp-content/uploads/sites/12/2024/07/Woolly_mammoth_Mammuthus_primigenius_-_Mauricio_Anton.jpg);" title="“Extinction” Echoes Jurassic Park, with a Pleistocene Backdrop"></a> <div class="post-list__post-text"> <span class="post-list__post-label">post</span> <span class="post-list__post-title"> <a href="https://dnascience.plos.org/2024/07/11/extinction-echoes-jurassic-park-with-a-pleistocene-backdrop/">“Extinction” Echoes Jurassic Park, with a Pleistocene Backdrop</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">July 11, 2024</span> <span class="post-list__post-author">By <a href="https://dnascience.plos.org/author/rlewis/">Ricki Lewis, PhD</a></span> </div> <div class="post-list__post-excerpt"> <p>Multiple spoiler alert! In the classic film Jurassic Park (JP) from 1993, disasters unfurl at a theme park populated with dinosaurs cloned…</p> </div> <a class="post-list__post-read-more" href="https://dnascience.plos.org/2024/07/11/extinction-echoes-jurassic-park-with-a-pleistocene-backdrop/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://dnascience.plos.org/2024/06/27/crispr-to-reveal-how-water-bears-tardigrades-survive-extreme-environments/" style="background-image: url(https://dnascience.plos.org/wp-content/uploads/sites/12/2024/06/SEM_image_of_Milnesium_tardigradum_in_active_state_-_journal.pone_.0045682.g001-2_white_background.png);" title="CRISPR to Reveal How “Water Bears” (Tardigrades) Survive Extreme Environments"></a> <div class="post-list__post-text"> <span class="post-list__post-label">post</span> <span class="post-list__post-title"> <a href="https://dnascience.plos.org/2024/06/27/crispr-to-reveal-how-water-bears-tardigrades-survive-extreme-environments/">CRISPR to Reveal How “Water Bears” (Tardigrades) Survive Extreme Environments</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">June 27, 2024</span> <span class="post-list__post-author">By <a href="https://dnascience.plos.org/author/rlewis/">Ricki Lewis, PhD</a></span> </div> <div class="post-list__post-excerpt"> <p>Tardigrades are among the weirdest of animals. Also known as “water bears” or “moss piglets,” the 1,300 recognized species are the only…</p> </div> <a class="post-list__post-read-more" href="https://dnascience.plos.org/2024/06/27/crispr-to-reveal-how-water-bears-tardigrades-survive-extreme-environments/">Read more</a> </div> </li> <li class="post-list__post post-list__post--has-image-yes post-list__post--image-above post-list__post--post"> <a class="post-list__post-image" href="https://dnascience.plos.org/2024/06/20/can-engineered-tobacco-plants-that-make-human-sugars-improve-infant-formula-and-plant-based-milks/" style="background-image: url(https://dnascience.plos.org/wp-content/uploads/sites/12/2024/06/milk-tobacco-rotated.jpg);" title="Can Engineered Tobacco Plants that Make Human Sugars Improve Infant Formula and Plant-Based Milks?"></a> <div class="post-list__post-text"> <span class="post-list__post-label">post</span> <span class="post-list__post-title"> <a href="https://dnascience.plos.org/2024/06/20/can-engineered-tobacco-plants-that-make-human-sugars-improve-infant-formula-and-plant-based-milks/">Can Engineered Tobacco Plants that Make Human Sugars Improve Infant Formula and Plant-Based Milks?</a> </span> <div class="post-list__post-meta"> <span class="post-list__post-date">June 20, 2024</span> <span class="post-list__post-author">By <a href="https://dnascience.plos.org/author/rlewis/">Ricki Lewis, PhD</a></span> </div> <div class="post-list__post-excerpt"> <p>In an eclectic application of transgenic technology, researchers at the University of California at Berkeley and Davis describe retooling cells of a…</p> </div> <a class="post-list__post-read-more" href="https://dnascience.plos.org/2024/06/20/can-engineered-tobacco-plants-that-make-human-sugars-improve-infant-formula-and-plant-based-milks/">Read more</a> </div> </li> </ul> </div> <div class="archive__pagination archive__pagination--bottom"> <span class="archive__pagination-count">Showing 1 – 12 of 529 posts</span> <div class="pagination"> <ul class="pagination__list"> <li class="pagination__item pagination__item--prev pagination__item--inactive pagination__item--not-current"> <a>Prev</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--current"> <a href="/">1</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--not-current"> <a href="/page/2/">2</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--not-current"> <a href="/page/3/">3</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--not-current"> <a href="/page/4/">4</a> </li> <li class="pagination__item pagination__item--page pagination__item--active pagination__item--not-current"> <a href="/page/5/">5</a> </li> <li class="pagination__item pagination__item--dots pagination__item--inactive pagination__item--not-current"> <span class="pagination__dots">...</span> </li> <li class="pagination__item pagination__item--next pagination__item--active pagination__item--not-current"> <a href="/page/2/">Next</a> </li> </ul> <div class="pagination__mobile"> <div class="pagination__link"> <a href="" class="pagination__mobile-link pagination__mobile-link--inactive">Prev</a> </div> <div class="pagination__select-container"> <select class="pagination__select" data-total-pages="45"> <option value="/" selected>1</option> <option value="/page/2/" >2</option> <option value="/page/3/" >3</option> <option value="/page/4/" >4</option> <option value="/page/5/" >5</option> </select> </div> <div class="pagination__link"> <a href="/page/2/" class="pagination__mobile-link pagination__mobile-link--active">Next</a> </div> </div> </div> </div> </div> </main> </div> </div> <style type="text/css"> footer.app-footer { background-color: #050c2b; color: #ffffff; } footer.app-footer a, footer.app-footer label { color: #ffffff; } footer.app-footer input[type=text], footer.app-footer input[type=email] { background-color: #050c2b; border-color: #ffffff; color: #ffffff; } </style> <footer class="app-footer"> <div class="app-footer__container container"> <div class="app-footer__col app-footer__branding"> <a class="app-footer__brand" href="https://dnascience.plos.org/"> <img class="app-footer__logo" src="https://dnascience.plos.org/wp-content/uploads/2019/12/logo-white.svg" alt="DNA Science logo" /> </a> <ul class="social-media-links app-footer__social-media-links"> <li class="social-media-links__item social-media-links__item--twitter"> <a class="social-media-links__link" href="https://twitter.com/plos"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 20 20" aria-labelledby="twitter-icon-title"> <title id="twitter-icon-title">X (former Twitter)</title> <style type="text/css">.svg-twitter-fill{fill: #ffffff;}</style> <path class="svg-twitter-fill" d="M11.7,8.6L18.2,1h-1.6L11,7.6L6.4,1H1.2l6.9,10l-6.9,8h1.6l6-7l4.8,7h5.2L11.7,8.6L11.7,8.6z M9.5,11.1l-0.7-1L3.3,2.2h2.4l4.5,6.4l0.7,1l5.8,8.3h-2.4L9.5,11.1L9.5,11.1z"/> </svg> </a> </li> <li class="social-media-links__item social-media-links__item--facebook"> <a class="social-media-links__link" href="https://www.facebook.com/PLoS.org"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 20 20" aria-labelledby="facebook-icon-title"> <title id="facebook-icon-title">Facebook</title> <style type="text/css">.svg-facebook-fill{fill: #ffffff;}</style> <path class="svg-facebook-fill" d="M19.5 1.5v16.6c0 0.6-0.5 1.2-1.2 1.2h-4.8v-7.4h2.4l0.4-2.7h-2.8V7.1c0-0.8 0.4-1.2 1.2-1.2h1.8V3.4c0 0-0.8-0.1-1.9-0.1 -2.6 0-3.9 1.4-3.9 3.6v2.4H8.3v2.7h2.4v7.4h-9c-0.6 0-1.2-0.5-1.2-1.2V1.5c0-0.6 0.5-1.2 1.2-1.2h16.6C19 0.3 19.5 0.9 19.5 1.5z"/> </svg> </a> </li> <li class="social-media-links__item social-media-links__item--linkedin"> <a class="social-media-links__link" href="https://www.linkedin.com/company/public-library-of-science"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 20 20" aria-labelledby="linkedin-icon-title"> <title id="linkedin-icon-title">Linkedin</title> <style type="text/css">.svg-linkedin-fill{fill: #ffffff;}</style> <path class="svg-linkedin-fill" d="M2.9 5.1L2.9 5.1c-1.4 0-2.4-1-2.4-2.2 0-1.2 0.9-2.2 2.4-2.2 1.4 0 2.3 0.9 2.4 2.2C5.2 4.1 4.3 5.1 2.9 5.1zM4.9 7.1v12.3h-4V7.1H4.9zM11.2 19.3h-4V9.8c0 0-0.1-2.4-0.1-2.8h3.9l0.1 1.7c0.8-1.2 2-2.1 3.6-2.1 2.8 0 4.8 2 4.8 5.5v7.1h-4v-6.7c0-2-1-2.8-2.2-2.8 -1.2 0-2.2 0.8-2.2 2.4V19.3z"/> </svg> </a> </li> </ul> <span class="app-footer__info-text">PLOS is a nonprofit 501(c)(3) corporation, #C2354500, and is based in California, US</span> </div> <div class="app-footer__col app-footer__nav"> <div class="app-footer__nav-container"> <div class="menu-footer-navigation-container"><ul id="menu-footer-navigation" class="app-header__footer-nav"><li id="menu-item-1680" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-1680"><a href="https://plos.org/">Home</a></li> <li id="menu-item-309" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-309"><a href="https://plos.org/resources/">Resources</a></li> <li id="menu-item-308" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-308"><a href="https://plos.org/research-communities/">Research Communities</a></li> <li id="menu-item-383" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-383"><a href="https://plos.org/open-science/">Open Science</a></li> <li id="menu-item-412" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-412"><a href="https://plos.org/publish/">Publish with PLOS</a></li> <li id="menu-item-419" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-419"><a href="https://plos.org/about/">About PLOS</a></li> <li id="menu-item-34241" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-34241"><a href="https://plos.org/research-integrity-and-ethics/">Research Integrity and Publication Ethics</a></li> <li id="menu-item-8117" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-8117"><a href="https://plos.org/dei/">Diversity, Equity and Inclusion</a></li> <li id="menu-item-2817" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-2817"><a href="https://plos.org/media/">Press and Media</a></li> <li id="menu-item-1682" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1682"><a href="https://plos.org/about/contact/">Contact</a></li> <li id="menu-item-1683" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1683"><a href="https://plos.org/pay-invoice/">Pay Invoice</a></li> <li id="menu-item-1684" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1684"><a href="https://plos.org/careers/">Careers</a></li> <li id="menu-item-1685" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1685"><a href="https://plos.org/advertise/">Advertise</a></li> <li id="menu-item-35167" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-35167"><a href="https://plos.org/financial-overview/">Financial Overview</a></li> <li id="menu-item-25042" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-25042"><a href="https://plos.org/governance/">Governance</a></li> <li id="menu-item-1687" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-privacy-policy menu-item-1687"><a rel="privacy-policy" href="https://plos.org/privacy-policy/">Privacy Policy</a></li> <li id="menu-item-15441" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-15441"><a href="https://plos.org/cookies-policy/">Cookie Policy</a></li> <li id="menu-item-1688" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1688"><a href="https://plos.org/terms-of-use/">Terms of Use</a></li> <li id="menu-item-7340" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-7340"><a href="https://plos.org/payment-terms-and-conditions/">Payment Terms and Conditions</a></li> <li id="menu-item-1689" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1689"><a href="https://plos.org/text-and-data-mining/">Text & Data Mining</a></li> <li id="menu-item-11315" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-11315"><a href="https://plos.org/terms-of-service/">Terms of Service</a></li> </ul></div> </div> </div> <div class="app-footer__col app-footer__rich-text"> <p><strong>News & Updates</strong></p> <form class="newsletter-signup" action="https://cl.exct.net/subscribe.aspx" name="subscribeForm" method="post"><input type="hidden" name="thx" value="https://www.plos.org/signup-success/"><input type="hidden" name="err" value="https://www.plos.org/signup-error/"><input type="hidden" name="SubAction" value="sub"><input type="hidden" name="MID" value="7207856"><input type="hidden" name="LID" value="5488"><input type="hidden" name="Source" value="WebCollect"><div class="newsletter-signup__input-container newsletter-signup__input-container--text-container"><label for="email-address">Email address</label><input type="email" id="email-address" name="Email Address"></div><div class="newsletter-signup__input-container newsletter-signup__input-container--checkbox-container"><span class="newsletter-signup__disclaimer">PLOS will use your email address to provide news and updates. You can find out more about how PLOS processes your data by reading our <a href="https://plos.org/privacy-policy/">Privacy Policy</a>. You can unsubscribe at any time by clicking the unsubscribe link in our emails or by contacting us at privacy@plos.org.</span></div><div class="newsletter-signup__input-container newsletter-signup__input-container--submit-container"><small class="newsletter-signup__validation-message">All fields are required, please check your entry and try again.</small><input type="submit" value="Submit"></div></form> </div> </div> </footer> <a class="back-to-top" id="back-to-top" href="#top"><span class="screen-reader-text">Back to top</span></a>  <script> /*! For license information please see body.js.LICENSE.txt */ (()=>{var e={490:(e,t,n)=>{"use strict";function r(e){return(r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(e)}t.Z=void 0;var a=function(e,t){if(e&&e.__esModule)return e;if(null===e||"object"!==r(e)&&"function"!=typeof e)return{default:e};var n=s(t);if(n&&n.has(e))return n.get(e);var a={},l=Object.defineProperty&&Object.getOwnPropertyDescriptor;for(var o in e)if("default"!==o&&Object.prototype.hasOwnProperty.call(e,o)){var i=l?Object.getOwnPropertyDescriptor(e,o):null;i&&(i.get||i.set)?Object.defineProperty(a,o,i):a[o]=e[o]}return a.default=e,n&&n.set(e,a),a}(n(294)),l=u(n(177)),o=u(n(682)),i=u(n(628));function u(e){return e&&e.__esModule?e:{default:e}}function s(e){if("function"!=typeof WeakMap)return null;var t=new WeakMap,n=new WeakMap;return(s=function(e){return e?n:t})(e)}function c(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}t.Z=function(e){var t,n,r=e.dispatcher,u=(t=(0,a.useState)(!l.default.hasInteracted()),n=2,function(e){if(Array.isArray(e))return e}(t)||function(e,t){var n=null==e?null:"undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@iterator"];if(null!=n){var r,a,l=[],o=!0,i=!1;try{for(n=n.call(e);!(o=(r=n.next()).done)&&(l.push(r.value),!t||l.length!==t);o=!0);}catch(e){i=!0,a=e}finally{try{o||null==n.return||n.return()}finally{if(i)throw a}}return l}}(t,n)||function(e,t){if(e){if("string"==typeof e)return c(e,t);var n=Object.prototype.toString.call(e).slice(8,-1);return"Object"===n&&e.constructor&&(n=e.constructor.name),"Map"===n||"Set"===n?Array.from(e):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?c(e,t):void 0}}(t,n)||function(){throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}()),s=u[0],f=u[1];return r&&(0,a.useEffect)((function(){return r.sub("open",(function(){return f(!0)}))}),[]),a.default.createElement("div",{className:"cookie-consent"},a.default.createElement(o.default,{show:s}),a.default.createElement(i.default,{close:function(){f(!1)},show:s}))}},682:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r=o(n(294)),a=n(357),l=o(n(188));function o(e){return e&&e.__esModule?e:{default:e}}t.default=function(e){var t=e.show;return r.default.createElement(a.CSSTransition,{in:t,timeout:200,classNames:{enter:l.default.fadeInEnter,enterActive:l.default.fadeInEnterActive,exit:l.default.fadeInExit,exitActive:l.default.fadeInExitActive},unmountOnExit:!0},r.default.createElement("div",{className:l.default.overlay,role:"presentation"}))}},980:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0,t.default="data:image/svg+xml;charset=utf-8;base64,<?xml version="1.0" encoding="UTF-8"?>
<svg enable-background="new 0 0 944 620" version="1.1" viewBox="0 0 944 620" xml:space="preserve" xmlns="http://www.w3.org/2000/svg">
<style type="text/css">
  .st0{fill:#F63C3D;}
  .st1{fill:#17BAFA;}
  .st2{opacity:0.93;}
  .st3{fill:#18335A;}
  .st4{fill:#D2DA20;}
  .st5{opacity:0.83;}
  .st6{fill:#007165;}
</style>
<path class="st0" d="m558.68 69.77c2.45-2.8 5.82-5.98 10.89-6.67 3.77-0.52 7.15 0.04 9.97 2.66 8.02 7.42 16.31 14.57 23.95 22.37 17.3 17.66 33.04 36.73 48.18 56.28 14.36 18.54 27.69 37.85 40.26 57.7 3.72 5.88 7.51 11.72 11.2 17.62 3.4 5.44 6.75 10.91 10.04 16.41 3.31 5.52 6.52 11.1 9.77 16.66 3 5.12 6.12 10.17 8.96 15.38 4.47 8.2 8.81 16.46 13.07 24.78 3.13 6.12 6.07 12.34 9.05 18.54 3.75 7.81 7.66 15.55 11.12 23.49 3.36 7.72 6.33 15.62 9.31 23.51 2.89 7.66 5.65 15.37 8.32 23.11 0.74 2.16 0.85 4.54 1.46 6.76 1.78 6.5 4.07 12.88 5.43 19.48 1.9 9.21 3.18 18.55 4.63 27.86 0.57 3.63 0.94 7.31 1.26 10.98 0.06 0.72-0.54 1.51-0.84 2.27-0.64-0.6-1.7-1.09-1.86-1.81-1.77-7.92-2.97-16-5.16-23.78-3.17-11.23-6.68-22.38-10.69-33.32-3.75-10.23-8.06-20.27-12.64-30.14-4.69-10.1-9.82-20.01-15.11-29.8-5.29-9.8-10.81-19.47-16.58-28.98-6.61-10.9-13.43-21.68-20.49-32.28-9.59-14.43-19.33-28.76-29.31-42.91-8.46-12-17.17-23.83-26.09-35.47-9.8-12.78-19.77-25.45-30.07-37.83-9.11-10.95-18.56-21.63-28.25-32.05-9.3-9.98-19.07-19.52-28.72-29.17-3.59-3.59-7.57-6.79-11.11-10.43-3.55-3.66-3.52-5.99 0.05-11.22z"/>
<path class="st1" d="m733.08 66.49c3.63-0.83 8.23-1.42 12.74 0.99 3.36 1.8 5.76 4.23 6.51 8.01 2.13 10.72 4.65 21.37 6.26 32.17 3.64 24.45 5.19 49.13 5.97 73.85 0.74 23.44 0.2 46.9-1.28 70.34-0.44 6.95-0.8 13.9-1.28 20.84-0.44 6.4-0.94 12.79-1.5 19.18-0.57 6.41-1.24 12.81-1.87 19.22-0.58 5.9-1.01 11.82-1.77 17.71-1.2 9.26-2.53 18.5-3.96 27.73-1.05 6.79-2.33 13.55-3.56 20.32-1.55 8.52-2.93 17.08-4.79 25.54-1.81 8.22-4.04 16.36-6.26 24.5-2.15 7.9-4.45 15.76-6.83 23.59-0.66 2.18-1.98 4.18-2.79 6.33-2.37 6.31-4.27 12.82-7.04 18.95-3.87 8.57-8.32 16.89-12.61 25.27-1.67 3.27-3.53 6.47-5.42 9.63-0.37 0.62-1.33 0.91-2.02 1.35-0.17-0.86-0.74-1.88-0.45-2.56 3.22-7.45 6.99-14.7 9.78-22.28 4.03-10.95 7.73-22.04 10.91-33.25 2.97-10.48 5.37-21.14 7.46-31.82 2.13-10.93 3.79-21.96 5.26-33 1.47-11.03 2.68-22.11 3.59-33.19 1.04-12.7 1.85-25.43 2.37-38.16 0.7-17.31 1.23-34.63 1.46-51.95 0.19-14.68 0.09-29.37-0.3-44.03-0.43-16.1-1.06-32.21-2.13-48.28-0.95-14.21-2.32-28.4-4.06-42.53-1.66-13.54-3.98-27-6.13-40.47-0.8-5.02-2.15-9.95-2.87-14.97-0.75-5.03 0.65-6.89 6.61-9.03z"/>
<g class="st2">
<path class="st3" d="m433.01 108.31c0.53-3.63 1.63-8.06 5.53-11.36 2.9-2.45 6.05-3.8 9.87-3.16 10.83 1.82 21.75 3.27 32.47 5.61 24.27 5.29 48.01 12.58 71.5 20.6 22.28 7.6 44.11 16.38 65.59 26.02 6.36 2.86 12.76 5.65 19.11 8.54 5.85 2.66 11.67 5.38 17.47 8.16 5.82 2.78 11.59 5.67 17.37 8.51 5.33 2.62 10.74 5.11 15.99 7.88 8.26 4.37 16.46 8.86 24.61 13.43 6 3.37 11.89 6.93 17.8 10.44 7.45 4.43 14.98 8.73 22.26 13.43 7.07 4.57 13.91 9.5 20.75 14.41 6.64 4.77 13.19 9.65 19.69 14.61 1.81 1.38 3.21 3.3 4.94 4.8 5.07 4.41 10.5 8.45 15.26 13.17 6.65 6.58 12.85 13.61 19.18 20.51 2.47 2.7 4.8 5.53 7.08 8.39 0.45 0.56 0.37 1.54 0.54 2.33-0.87-0.15-2.03 0.01-2.56-0.49-5.83-5.59-11.28-11.61-17.4-16.86-8.83-7.57-17.91-14.89-27.28-21.77-8.77-6.43-17.91-12.4-27.19-18.09-9.5-5.82-19.26-11.24-29.09-16.49s-19.79-10.27-29.87-15.03c-11.55-5.45-23.21-10.68-34.98-15.65-16-6.76-32.08-13.36-48.26-19.69-13.71-5.36-27.54-10.45-41.46-15.27-15.28-5.29-30.63-10.4-46.1-15.09-13.69-4.15-27.51-7.9-41.4-11.29-13.32-3.25-26.79-5.88-40.21-8.66-5-1.04-10.11-1.54-15.1-2.65-5.01-1.11-6.26-3.06-6.11-9.29z"/>
</g>
<path class="st4" d="m823.28 220.35c3.56 1.08 7.85 2.85 10.57 7.18 2.02 3.23 2.9 6.53 1.68 10.18-3.46 10.36-6.56 20.86-10.53 31.04-8.97 23.03-19.87 45.23-31.45 67.08-10.99 20.72-23.09 40.82-36.01 60.44-3.83 5.81-7.59 11.67-11.45 17.46-3.56 5.34-7.16 10.64-10.82 15.91-3.67 5.29-7.43 10.51-11.16 15.76-3.43 4.84-6.75 9.76-10.32 14.49-5.63 7.45-11.37 14.81-17.2 22.11-4.28 5.37-8.74 10.61-13.17 15.88-5.57 6.63-11.02 13.38-16.83 19.8-5.65 6.24-11.63 12.2-17.59 18.17-5.78 5.79-11.68 11.47-17.64 17.09-1.66 1.57-3.79 2.64-5.56 4.11-5.19 4.3-10.07 9.01-15.52 12.96-7.61 5.52-15.6 10.53-23.48 15.69-3.08 2.01-6.27 3.87-9.49 5.67-0.63 0.35-1.6 0.13-2.42 0.17 0.28-0.83 0.29-2 0.88-2.44 6.49-4.87 13.36-9.29 19.55-14.5 8.93-7.51 17.65-15.3 25.96-23.46 7.78-7.63 15.15-15.69 22.26-23.93 7.28-8.44 14.19-17.19 20.94-26.04s13.3-17.87 19.59-27.04c7.21-10.51 14.22-21.16 20.99-31.96 9.2-14.68 18.25-29.46 27.04-44.38 7.45-12.65 14.65-25.45 21.58-38.38 7.61-14.2 15.06-28.5 22.1-42.98 6.23-12.81 12.07-25.81 17.57-38.94 5.27-12.58 9.94-25.41 14.76-38.18 1.79-4.75 3.07-9.7 4.93-14.42 1.87-4.72 4.01-5.65 10.24-4.54z"/>
<g class="st5">
<path class="st6" d="m852.54 369.84c1.86 3.22 3.78 7.45 2.79 12.47-0.73 3.74-2.35 6.75-5.74 8.58-9.62 5.18-19.06 10.72-28.92 15.43-22.3 10.66-45.44 19.39-68.84 27.39-22.19 7.59-44.77 13.96-67.62 19.43-6.77 1.62-13.52 3.31-20.3 4.9-6.24 1.46-12.5 2.86-18.77 4.19-6.29 1.34-12.61 2.58-18.92 3.86-5.81 1.18-11.6 2.5-17.45 3.5-9.2 1.58-18.43 3.02-27.67 4.36-6.8 0.99-13.64 1.75-20.47 2.57-8.6 1.02-17.19 2.22-25.83 2.92-8.39 0.68-16.83 0.94-25.26 1.21-8.18 0.26-16.37 0.37-24.56 0.4-2.28 0.01-4.57-0.67-6.87-0.81-6.73-0.42-13.51-0.32-20.19-1.17-9.32-1.18-18.58-2.99-27.86-4.63-3.62-0.64-7.22-1.47-10.79-2.36-0.7-0.17-1.26-1-1.88-1.53 0.77-0.41 1.58-1.26 2.31-1.18 8.06 0.89 16.1 2.36 24.17 2.81 11.65 0.64 23.34 0.92 34.98 0.66 10.89-0.24 21.79-1.07 32.61-2.22 11.08-1.17 22.11-2.83 33.09-4.66s21.92-3.93 32.78-6.31c12.45-2.73 24.86-5.7 37.17-8.94 16.75-4.41 33.47-8.99 50.09-13.86 14.09-4.12 28.1-8.54 42-13.22 15.27-5.14 30.48-10.47 45.52-16.22 13.31-5.08 26.47-10.56 39.46-16.37 12.45-5.57 24.64-11.73 36.89-17.74 4.56-2.24 8.88-4.97 13.47-7.14 4.62-2.18 6.82-1.39 10.61 3.68z"/>
</g>
<circle class="st6" cx="809.09" cy="136.91" r="15.09"/>
<circle class="st3" cx="654.73" cy="35.79" r="15.09"/>
<circle class="st3" cx="486.18" cy="530.81" r="15.09"/>
<circle class="st3" cx="766.76" cy="496.13" r="15.09"/>
<circle class="st4" cx="624.54" cy="500.63" r="15.09"/>
<circle class="st4" cx="501.28" cy="50.88" r="15.09"/>
<circle class="st0" cx="858.6" cy="330.29" r="15.09"/>
<path class="st3" d="m56.96 240.33h67.34c40.02 0 64.9 22.69 64.9 57.1v0.49c0 38.31-30.74 58.32-68.32 58.32h-33.91v54.9h-30.01v-170.81zm64.91 88.82c22.69 0 36.84-12.69 36.84-30.5v-0.49c0-20.01-14.4-30.5-36.84-30.5h-34.9v61.49h34.9z"/>
<path class="st3" d="m219.95 240.33h30.01v143.47h89.79v27.33h-119.8v-170.8z"/>
<path class="st3" d="m352.69 326.22v-0.49c0-48.07 37.09-88.33 89.55-88.33s89.06 39.77 89.06 87.84v0.49c0 48.07-37.09 88.33-89.55 88.33s-89.06-39.77-89.06-87.84zm147.13 0v-0.49c0-33.18-24.16-60.51-58.07-60.51s-57.58 26.84-57.58 60.02v0.49c0 33.18 24.16 60.51 58.07 60.51 33.91 0.01 57.58-26.83 57.58-60.02z"/>
  <path class="st3" d="m554.96 386.25 18.06-21.47c16.35 14.15 32.94 22.2 53.92 22.2 18.54 0 30.26-8.78 30.26-21.47v-0.49c0-12.2-6.83-18.79-38.55-26.11-36.36-8.78-56.85-19.52-56.85-51v-0.49c0-29.28 24.4-49.53 58.32-49.53 24.89 0 44.65 7.56 61.98 21.47l-16.1 22.69c-15.37-11.47-30.74-17.57-46.36-17.57-17.57 0-27.82 9.03-27.82 20.25v0.49c0 13.18 7.81 19.03 40.75 26.84 36.11 8.78 54.66 21.72 54.66 50.02v0.49c0 31.96-25.13 51-61 51-26.13 0.01-50.77-9.02-71.27-27.32z"/>
</svg>"},905:(e,t,n)=>{"use strict";function r(e){return(r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(e)}Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var a=function(e,t){if(e&&e.__esModule)return e;if(null===e||"object"!==r(e)&&"function"!=typeof e)return{default:e};var n=s(t);if(n&&n.has(e))return n.get(e);var a={},l=Object.defineProperty&&Object.getOwnPropertyDescriptor;for(var o in e)if("default"!==o&&Object.prototype.hasOwnProperty.call(e,o)){var i=l?Object.getOwnPropertyDescriptor(e,o):null;i&&(i.get||i.set)?Object.defineProperty(a,o,i):a[o]=e[o]}return a.default=e,n&&n.set(e,a),a}(n(294)),l=u(n(177)),o=u(n(413)),i=u(n(141));function u(e){return e&&e.__esModule?e:{default:e}}function s(e){if("function"!=typeof WeakMap)return null;var t=new WeakMap,n=new WeakMap;return(s=function(e){return e?n:t})(e)}function c(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}t.default=function(e){var t,n,r=e.title,u=e.code,s=e.children,f=e.alwaysOn,d=void 0!==f&&f,p=(t=(0,a.useState)(!1),n=2,function(e){if(Array.isArray(e))return e}(t)||function(e,t){var n=null==e?null:"undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@iterator"];if(null!=n){var r,a,l=[],o=!0,i=!1;try{for(n=n.call(e);!(o=(r=n.next()).done)&&(l.push(r.value),!t||l.length!==t);o=!0);}catch(e){i=!0,a=e}finally{try{o||null==n.return||n.return()}finally{if(i)throw a}}return l}}(t,n)||function(e,t){if(e){if("string"==typeof e)return c(e,t);var n=Object.prototype.toString.call(e).slice(8,-1);return"Object"===n&&e.constructor&&(n=e.constructor.name),"Map"===n||"Set"===n?Array.from(e):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?c(e,t):void 0}}(t,n)||function(){throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}()),y=p[0],h=p[1],g=d?a.default.createElement("div",{className:o.default.alwaysOnMessage},"Always On"):a.default.createElement(i.default,{onClick:function(e){return function(e,t){"INPUT"===t.target.tagName&&l.default.customize(e,t.target.checked)}(u,e)},defaultChecked:l.default.hasConsented(u)}),m=function(){h(!y)};return a.default.createElement("div",{className:o.default.cookieType},a.default.createElement("div",{className:o.default.switchContainer},a.default.createElement("div",{role:"button",className:o.default.toggleExplanation,onClick:m,onKeyDown:m,tabIndex:0,"aria-label":"Toggle explanation of ".concat(r," Cookies.")},a.default.createElement("span",{className:o.default.toggleIcon},y?"-":"+"),a.default.createElement("strong",{className:o.default.toggleTitle},r)),a.default.createElement("div",{className:o.default.spacer}),g),!!y&&a.default.createElement("div",{className:o.default.explanationContainer},a.default.createElement("div",{className:o.default.toggleIcon}," "),s))}},628:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r=s(n(294)),a=n(357),l=s(n(177)),o=s(n(905)),i=s(n(810)),u=s(n(980));function s(e){return e&&e.__esModule?e:{default:e}}t.default=function(e){var t=e.close,n=e.show;return r.default.createElement(a.CSSTransition,{in:n,timeout:200,classNames:{enter:i.default.slideOutEnter,enterActive:i.default.slideOutEnterActive,exit:i.default.slideOutExit,exitActive:i.default.slideOutExitActive},unmountOnExit:!0},r.default.createElement("div",{className:i.default.slideOut},r.default.createElement("div",{className:i.default.plosLogoWrapper},r.default.createElement("div",null,r.default.createElement("img",{alt:"PLOS Logo",className:i.default.plosLogo,src:u.default})),r.default.createElement("h3",{className:i.default.heading},"Cookie Preference Center")),r.default.createElement("p",{className:i.default.text},"Our website uses different types of cookies. Optional cookies will only be set with your consent and you may withdraw this consent at any time. Below you can learn more about the types of cookies PLOS uses and register your cookie preferences."),r.default.createElement("div",{className:i.default.buttonContainer},r.default.createElement("button",{type:"submit",onClick:function(){l.default.accept(),t()}},"Accept All Cookies")),r.default.createElement("div",null,r.default.createElement("h3",{className:i.default.customizeHeading},"Customize Your Cookie Preference"),r.default.createElement(o.default,{title:"Strictly Necessary",alwaysOn:!0},"These cookies are necessary to operating the PLOS website. They provide site security, help balance load on our servers, and other essential functions."),r.default.createElement(o.default,{title:"Functional",code:"functionality"},"These cookies and other technologies provide useful site functionality such as remembering your site preferences, allowing you to navigate the PLOS site more efficiently."),r.default.createElement(o.default,{title:"Performance and Analytics",code:"analytics"},"These cookies and other technologies analyze how the PLOS website is accessed, used, and performing in order to maintain and continually improve user experience on the site."),r.default.createElement(o.default,{title:"Marketing",code:"advertising"},"These cookies deliver contextual advertisements on the PLOS site and help third-parties serve you targeted advertisements based on your browsing history.")),r.default.createElement("div",{className:i.default.spacer}),r.default.createElement("div",{className:i.default.buttonContainer},r.default.createElement("button",{type:"submit",onClick:function(){l.default.hasInteracted()||l.default.reject(),t()}},"Save Selected Preferences and Close")),r.default.createElement("a",{className:i.default.underline,href:"https://plos.org/cookies-policy",target:"_blank",rel:"noreferrer"},"For more information about the cookies and other technologies used by us, please read our Cookie Policy.")))}},141:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r=o(n(294)),a=o(n(403)),l=o(n(454));function o(e){return e&&e.__esModule?e:{default:e}}function i(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}t.default=function(e){var t,n,o=e.defaultChecked,u=e.onClick,s=e.disabled,c=void 0!==s&&s,f="switch"+(t=r.default.useState((0,a.default)()),n=1,function(e){if(Array.isArray(e))return e}(t)||function(e,t){var n=null==e?null:"undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@iterator"];if(null!=n){var r,a,l=[],o=!0,i=!1;try{for(n=n.call(e);!(o=(r=n.next()).done)&&(l.push(r.value),!t||l.length!==t);o=!0);}catch(e){i=!0,a=e}finally{try{o||null==n.return||n.return()}finally{if(i)throw a}}return l}}(t,n)||function(e,t){if(e){if("string"==typeof e)return i(e,t);var n=Object.prototype.toString.call(e).slice(8,-1);return"Object"===n&&e.constructor&&(n=e.constructor.name),"Map"===n||"Set"===n?Array.from(e):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?i(e,t):void 0}}(t,n)||function(){throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}())[0];return r.default.createElement("div",{className:l.default.switch},r.default.createElement("input",{className:l.default.input,disabled:c,id:f,type:"checkbox",defaultChecked:o,onChange:u}),r.default.createElement("label",{className:l.default.paddle,htmlFor:f},r.default.createElement("span",{className:l.default.active},"On"),r.default.createElement("span",{className:l.default.inactive},"Off")))}},403:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var n=0;t.default=function(){return n++}},773:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.VALID_PURPOSES=t.RECONSENT_INTERVAL=t.COOKIE_KEY=void 0,t.COOKIE_KEY="plosCookieConsentStatus",t.RECONSENT_INTERVAL=180,t.VALID_PURPOSES=["advertising","analytics","functionality"]},502:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r,a=(r=n(808))&&r.__esModule?r:{default:r},l=n(773);function o(e){return Object.assign({},...l.VALID_PURPOSES.map((t=>({[t]:e}))))}var i={get:function(){try{const e=JSON.parse(a.default.get(l.COOKIE_KEY));return e?!0===e?o(!0):e:o(!1)}catch(e){return o(!1)}},isSet:function(){return void 0!==a.default.get(l.COOKIE_KEY)},remove:function(){a.default.remove(l.COOKIE_KEY)},set:function(e){const t=window.location.hostname;a.default.set(l.COOKIE_KEY,e,{domain:("localhost"===t?"":".")+t.split(".").slice(-2).join("."),expires:l.RECONSENT_INTERVAL})}};t.default=i},177:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=void 0;var r,a=(r=n(502))&&r.__esModule?r:{default:r},l=n(773);function o(){var e,t;null===(e=(t=window).gtmOnConsent)||void 0===e||e.call(t,a.default.get())}var i={accept:function(){a.default.set(!0),o()},customize:function(e,t){a.default.set(Object.assign(a.default.get(),{[e]:t})),o()},hasConsented:function(e){if(!l.VALID_PURPOSES.includes(e))throw new Error("Invalid cookie purpose: "+e+" - Not in "+l.VALID_PURPOSES.toString());return a.default.get()[e]},hasInteracted:function(){return a.default.isSet()},reject:function(){a.default.set(!1),o()},reset:function(){a.default.remove()},VALID_PURPOSES:l.VALID_PURPOSES};t.default=i},151:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,"._2w1UwhvJHT_qwQKK4m2Mtf{background-color:#333;bottom:0;left:0;position:fixed;right:0;opacity:.5;top:0;z-index:1}._1y82vgULYYDGyWdjHVia6r{opacity:0}._367_oaFBsPkUkmVR1bGNYm{opacity:.5;transition:opacity 200ms}._2dI2_nwyJPeiTPjhARwALQ{opacity:.5}._2f5ts8uYo0Bpq4XYl7aiJU{opacity:0;transition:opacity 200ms}",""]),a.locals={overlay:"_2w1UwhvJHT_qwQKK4m2Mtf",fadeInEnter:"_1y82vgULYYDGyWdjHVia6r",fadeInEnterActive:"_367_oaFBsPkUkmVR1bGNYm",fadeInExit:"_2dI2_nwyJPeiTPjhARwALQ",fadeInExitActive:"_2f5ts8uYo0Bpq4XYl7aiJU"};const l=a},148:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,"._3A__ku4NC-f73WZK-2WSLx{flex-grow:1}._2CmoA8p3s0vKIspSCosl9G{cursor:pointer;display:flex;font-weight:bold}._3UCm4aXUK13m4R_iCXSEyn{display:inline-block;flex:0 0 1em}._2qXwuhqwMHjam4FPIz7LCs{flex-shrink:0}.l1QQ8S-nhYCUogSWaE0yF,.s4KCa9TCuz7L8vB3Y0Zto{align-items:center;display:flex;margin-bottom:4px;min-height:32px}._1FFdDFwCKdHcKsmbvSZf6_{margin-right:2px;font-style:italic}",""]),a.locals={spacer:"_3A__ku4NC-f73WZK-2WSLx",toggleExplanation:"_2CmoA8p3s0vKIspSCosl9G",toggleIcon:"_3UCm4aXUK13m4R_iCXSEyn",toggleTitle:"_2qXwuhqwMHjam4FPIz7LCs",switchContainer:"l1QQ8S-nhYCUogSWaE0yF",explanationContainer:"s4KCa9TCuz7L8vB3Y0Zto",alwaysOnMessage:"_1FFdDFwCKdHcKsmbvSZf6_"};const l=a},908:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,"._1tEo1q2cUK9NIysoJrVPWB{background-color:#fff;bottom:0;color:#1c2e5e;display:flex;flex-direction:column;font-size:14px;max-height:100%;max-width:95%;min-width:320px;padding:16px;position:fixed;overflow-y:auto;top:0;width:25%;z-index:2}.T1Y5lu3DhJYBpNej0XUqn{left:-100vw}._1LboXNkeCnS8lrcYjApaZG{left:0;transition:left 200ms}.M0lj2upZTiu02JJDGvGB{left:0}._3MASX-v6vhk8saSO9VmJ6U{left:-100vw;transition:left 200ms}._28VwqbFjT3AsGRoYLhfgjy{color:#1c2e5e;font-size:20px;font-weight:bold}.xI7u62vIvKFhmZX2xirm- ._28VwqbFjT3AsGRoYLhfgjy{margin-bottom:0}._1rHZW01Wf74DBd08dYWESO{height:40px;margin-right:5px;width:auto}.xI7u62vIvKFhmZX2xirm-{align-items:center;display:flex;flex-direction:row}._369CBb-mfyjgJZcxE85upM{font-size:14px}._1u4ynVnXwZaZEsjTHxtV0v{flex-grow:1}._29PzLWpueUEyRToV1hjZjn{display:flex;flex-wrap:wrap;justify-content:space-around;margin-top:16px;margin-bottom:24px}@media(max-width: 1500px){._29PzLWpueUEyRToV1hjZjn{flex-direction:column}}._29PzLWpueUEyRToV1hjZjn button{background-color:#1c2e5e;border:1px solid #000;border-radius:5px;color:#fff;cursor:pointer;font-size:14px;font-weight:bold;flex-grow:1;padding:8px;white-space:nowrap}@media(max-width: 1500px){._29PzLWpueUEyRToV1hjZjn button~button{margin-top:12px}}@media(min-width: 1501px){._29PzLWpueUEyRToV1hjZjn button~button{margin-left:12px}}.ITkiffnwKKM34XaIHLjB_{color:#1c2e5e;font-size:14px;font-weight:bold}._38RYPxeKGNUF74SufFb2Cn{text-decoration:underline;text-decoration-color:blue}",""]),a.locals={slideOut:"_1tEo1q2cUK9NIysoJrVPWB",slideOutEnter:"T1Y5lu3DhJYBpNej0XUqn",slideOutEnterActive:"_1LboXNkeCnS8lrcYjApaZG",slideOutExit:"M0lj2upZTiu02JJDGvGB",slideOutExitActive:"_3MASX-v6vhk8saSO9VmJ6U",heading:"_28VwqbFjT3AsGRoYLhfgjy",plosLogoWrapper:"xI7u62vIvKFhmZX2xirm-",plosLogo:"_1rHZW01Wf74DBd08dYWESO",text:"_369CBb-mfyjgJZcxE85upM",spacer:"_1u4ynVnXwZaZEsjTHxtV0v",buttonContainer:"_29PzLWpueUEyRToV1hjZjn",customizeHeading:"ITkiffnwKKM34XaIHLjB_",underline:"_38RYPxeKGNUF74SufFb2Cn"};const l=a},174:(e,t,n)=>{"use strict";n.d(t,{Z:()=>l});var r=n(645),a=n.n(r)()((function(e){return e[1]}));a.push([e.id,'._2ynah8Lgqwdr9aOADyNLnm{color:#fefefe;font-size:12px;font-weight:bold;height:32px;outline:0;position:relative;user-select:none}._16DjzBVfVPFmQVgTgNlqAD{margin-bottom:0;opacity:0;position:absolute}._2o1hzYk15DlFY9KaHai3O2{background:#cacaca;border-radius:16px;color:inherit;cursor:pointer;display:block;font-weight:inherit;height:32px;position:relative;transition:all .25s ease-out;width:64px}._2o1hzYk15DlFY9KaHai3O2::after{background:#fefefe;border-radius:14px;content:"";display:block;height:24px;left:4px;position:absolute;transform:translate3d(0, 0, 0);transition:all .25s ease-out;top:4px;width:24px}input:checked~._2o1hzYk15DlFY9KaHai3O2::after{left:36px}input:checked~._2o1hzYk15DlFY9KaHai3O2{background:#32a960}._3vFoGG1De0BqwBpqyyWHgM{display:none;left:10%}input:checked+label>._3vFoGG1De0BqwBpqyyWHgM{display:block}._3vFoGG1De0BqwBpqyyWHgM,.KUzu_RflxRcodvteC94f5{position:absolute;transform:translateY(-50%);top:50%}.KUzu_RflxRcodvteC94f5{right:15%}input:checked+label>.KUzu_RflxRcodvteC94f5{display:none}',""]),a.locals={switch:"_2ynah8Lgqwdr9aOADyNLnm",input:"_16DjzBVfVPFmQVgTgNlqAD",paddle:"_2o1hzYk15DlFY9KaHai3O2",active:"_3vFoGG1De0BqwBpqyyWHgM",inactive:"KUzu_RflxRcodvteC94f5"};const l=a},645:e=>{"use strict";e.exports=function(e){var t=[];return t.toString=function(){return this.map((function(t){var n=e(t);return t[2]?"@media ".concat(t[2]," {").concat(n,"}"):n})).join("")},t.i=function(e,n,r){"string"==typeof e&&(e=[[null,e,""]]);var a={};if(r)for(var l=0;l<this.length;l++){var o=this[l][0];null!=o&&(a[o]=!0)}for(var i=0;i<e.length;i++){var u=[].concat(e[i]);r&&a[u[0]]||(n&&(u[2]?u[2]="".concat(n," and ").concat(u[2]):u[2]=n),t.push(u))}},t}},808:(e,t,n)=>{var r,a,l;void 0===(a="function"==typeof(r=l=function(){function e(){for(var e=0,t={};e<arguments.length;e++){var n=arguments[e];for(var r in n)t[r]=n[r]}return t}function t(e){return e.replace(/(%[0-9A-Z]{2})+/g,decodeURIComponent)}return function n(r){function a(){}function l(t,n,l){if("undefined"!=typeof document){"number"==typeof(l=e({path:"/"},a.defaults,l)).expires&&(l.expires=new Date(1*new Date+864e5*l.expires)),l.expires=l.expires?l.expires.toUTCString():"";try{var o=JSON.stringify(n);/^[\{\[]/.test(o)&&(n=o)}catch(e){}n=r.write?r.write(n,t):encodeURIComponent(String(n)).replace(/%(23|24|26|2B|3A|3C|3E|3D|2F|3F|40|5B|5D|5E|60|7B|7D|7C)/g,decodeURIComponent),t=encodeURIComponent(String(t)).replace(/%(23|24|26|2B|5E|60|7C)/g,decodeURIComponent).replace(/[]/g,escape);var i="";for(var u in l)l[u]&&(i+="; "+u,!0!==l[u]&&(i+="="+l[u].split(";")[0]));return document.cookie=t+"="+n+i}}function o(e,n){if("undefined"!=typeof document){for(var a={},l=document.cookie?document.cookie.split("; "):[],o=0;o<l.length;o++){var i=l[o].split("="),u=i.slice(1).join("=");n||'"'!==u.charAt(0)||(u=u.slice(1,-1));try{var s=t(i[0]);if(u=(r.read||r)(u,s)||t(u),n)try{u=JSON.parse(u)}catch(e){}if(a[s]=u,e===s)break}catch(e){}}return e?a[e]:a}}return a.set=l,a.get=function(e){return o(e,!1)},a.getJSON=function(e){return o(e,!0)},a.remove=function(t,n){l(t,"",e(n,{expires:-1}))},a.defaults={},a.withConverter=n,a}((function(){}))})?r.call(t,n,t,e):r)||(e.exports=a),e.exports=l()},418:e=>{"use strict";var t=Object.getOwnPropertySymbols,n=Object.prototype.hasOwnProperty,r=Object.prototype.propertyIsEnumerable;function a(e){if(null==e)throw new TypeError("Object.assign cannot be called with null or undefined");return Object(e)}e.exports=function(){try{if(!Object.assign)return!1;var e=new String("abc");if(e[5]="de","5"===Object.getOwnPropertyNames(e)[0])return!1;for(var t={},n=0;n<10;n++)t["_"+String.fromCharCode(n)]=n;if("0123456789"!==Object.getOwnPropertyNames(t).map((function(e){return t[e]})).join(""))return!1;var r={};return"abcdefghijklmnopqrst".split("").forEach((function(e){r[e]=e})),"abcdefghijklmnopqrst"===Object.keys(Object.assign({},r)).join("")}catch(e){return!1}}()?Object.assign:function(e,l){for(var o,i,u=a(e),s=1;s<arguments.length;s++){for(var c in o=Object(arguments[s]))n.call(o,c)&&(u[c]=o[c]);if(t){i=t(o);for(var f=0;f<i.length;f++)r.call(o,i[f])&&(u[i[f]]=o[i[f]])}}return u}},448:(e,t,n)=>{"use strict";var r=n(294),a=n(418),l=n(840);function o(e){for(var t="https://reactjs.org/docs/error-decoder.html?invariant="+e,n=1;n<arguments.length;n++)t+="&args[]="+encodeURIComponent(arguments[n]);return"Minified React error #"+e+"; visit "+t+" for the full message or use the non-minified dev environment for full errors and additional helpful warnings."}if(!r)throw Error(o(227));var i=new Set,u={};function s(e,t){c(e,t),c(e+"Capture",t)}function c(e,t){for(u[e]=t,e=0;e<t.length;e++)i.add(t[e])}var f=!("undefined"==typeof window||void 0===window.document||void 0===window.document.createElement),d=/^[:A-Z_a-z\u00C0-\u00D6\u00D8-\u00F6\u00F8-\u02FF\u0370-\u037D\u037F-\u1FFF\u200C-\u200D\u2070-\u218F\u2C00-\u2FEF\u3001-\uD7FF\uF900-\uFDCF\uFDF0-\uFFFD][:A-Z_a-z\u00C0-\u00D6\u00D8-\u00F6\u00F8-\u02FF\u0370-\u037D\u037F-\u1FFF\u200C-\u200D\u2070-\u218F\u2C00-\u2FEF\u3001-\uD7FF\uF900-\uFDCF\uFDF0-\uFFFD\-.0-9\u00B7\u0300-\u036F\u203F-\u2040]*$/,p=Object.prototype.hasOwnProperty,y={},h={};function g(e,t,n,r,a,l,o){this.acceptsBooleans=2===t||3===t||4===t,this.attributeName=r,this.attributeNamespace=a,this.mustUseProperty=n,this.propertyName=e,this.type=t,this.sanitizeURL=l,this.removeEmptyString=o}var m={};"children dangerouslySetInnerHTML defaultValue defaultChecked innerHTML suppressContentEditableWarning suppressHydrationWarning style".split(" ").forEach((function(e){m[e]=new g(e,0,!1,e,null,!1,!1)})),[["acceptCharset","accept-charset"],["className","class"],["htmlFor","for"],["httpEquiv","http-equiv"]].forEach((function(e){var t=e[0];m[t]=new g(t,1,!1,e[1],null,!1,!1)})),["contentEditable","draggable","spellCheck","value"].forEach((function(e){m[e]=new g(e,2,!1,e.toLowerCase(),null,!1,!1)})),["autoReverse","externalResourcesRequired","focusable","preserveAlpha"].forEach((function(e){m[e]=new g(e,2,!1,e,null,!1,!1)})),"allowFullScreen async autoFocus autoPlay controls default defer disabled disablePictureInPicture disableRemotePlayback formNoValidate hidden loop noModule noValidate open playsInline readOnly required reversed scoped seamless itemScope".split(" ").forEach((function(e){m[e]=new g(e,3,!1,e.toLowerCase(),null,!1,!1)})),["checked","multiple","muted","selected"].forEach((function(e){m[e]=new g(e,3,!0,e,null,!1,!1)})),["capture","download"].forEach((function(e){m[e]=new g(e,4,!1,e,null,!1,!1)})),["cols","rows","size","span"].forEach((function(e){m[e]=new g(e,6,!1,e,null,!1,!1)})),["rowSpan","start"].forEach((function(e){m[e]=new g(e,5,!1,e.toLowerCase(),null,!1,!1)}));var v=/[\-:]([a-z])/g;function b(e){return e[1].toUpperCase()}function M(e,t,n,r){var a=m.hasOwnProperty(t)?m[t]:null;(null!==a?0===a.type:!r&&2<t.length&&("o"===t[0]||"O"===t[0])&&("n"===t[1]||"N"===t[1]))||(function(e,t,n,r){if(null==t||function(e,t,n,r){if(null!==n&&0===n.type)return!1;switch(typeof t){case"function":case"symbol":return!0;case"boolean":return!r&&(null!==n?!n.acceptsBooleans:"data-"!==(e=e.toLowerCase().slice(0,5))&&"aria-"!==e);default:return!1}}(e,t,n,r))return!0;if(r)return!1;if(null!==n)switch(n.type){case 3:return!t;case 4:return!1===t;case 5:return isNaN(t);case 6:return isNaN(t)||1>t}return!1}(t,n,a,r)&&(n=null),r||null===a?function(e){return!!p.call(h,e)||!p.call(y,e)&&(d.test(e)?h[e]=!0:(y[e]=!0,!1))}(t)&&(null===n?e.removeAttribute(t):e.setAttribute(t,""+n)):a.mustUseProperty?e[a.propertyName]=null===n?3!==a.type&&"":n:(t=a.attributeName,r=a.attributeNamespace,null===n?e.removeAttribute(t):(n=3===(a=a.type)||4===a&&!0===n?"":""+n,r?e.setAttributeNS(r,t,n):e.setAttribute(t,n))))}"accent-height alignment-baseline arabic-form baseline-shift cap-height clip-path clip-rule color-interpolation color-interpolation-filters color-profile color-rendering dominant-baseline enable-background fill-opacity fill-rule flood-color flood-opacity font-family font-size font-size-adjust font-stretch font-style font-variant font-weight glyph-name glyph-orientation-horizontal glyph-orientation-vertical horiz-adv-x horiz-origin-x image-rendering letter-spacing lighting-color marker-end marker-mid marker-start overline-position overline-thickness paint-order panose-1 pointer-events rendering-intent shape-rendering stop-color stop-opacity strikethrough-position strikethrough-thickness stroke-dasharray stroke-dashoffset stroke-linecap stroke-linejoin stroke-miterlimit stroke-opacity stroke-width text-anchor text-decoration text-rendering underline-position underline-thickness unicode-bidi unicode-range units-per-em v-alphabetic v-hanging v-ideographic v-mathematical vector-effect vert-adv-y vert-origin-x vert-origin-y word-spacing writing-mode xmlns:xlink x-height".split(" ").forEach((function(e){var t=e.replace(v,b);m[t]=new g(t,1,!1,e,null,!1,!1)})),"xlink:actuate xlink:arcrole xlink:role xlink:show xlink:title xlink:type".split(" ").forEach((function(e){var t=e.replace(v,b);m[t]=new g(t,1,!1,e,"http://www.w3.org/1999/xlink",!1,!1)})),["xml:base","xml:lang","xml:space"].forEach((function(e){var t=e.replace(v,b);m[t]=new g(t,1,!1,e,"http://www.w3.org/XML/1998/namespace",!1,!1)})),["tabIndex","crossOrigin"].forEach((function(e){m[e]=new g(e,1,!1,e.toLowerCase(),null,!1,!1)})),m.xlinkHref=new g("xlinkHref",1,!1,"xlink:href","http://www.w3.org/1999/xlink",!0,!1),["src","href","action","formAction"].forEach((function(e){m[e]=new g(e,1,!1,e.toLowerCase(),null,!0,!0)}));var E=r.__SECRET_INTERNALS_DO_NOT_USE_OR_YOU_WILL_BE_FIRED,L=60103,N=60106,w=60107,S=60108,x=60114,k=60109,j=60110,T=60112,C=60113,I=60120,D=60115,O=60116,z=60121,A=60128,_=60129,P=60130,U=60131;if("function"==typeof Symbol&&Symbol.for){var Y=Symbol.for;L=Y("react.element"),N=Y("react.portal"),w=Y("react.fragment"),S=Y("react.strict_mode"),x=Y("react.profiler"),k=Y("react.provider"),j=Y("react.context"),T=Y("react.forward_ref"),C=Y("react.suspense"),I=Y("react.suspense_list"),D=Y("react.memo"),O=Y("react.lazy"),z=Y("react.block"),Y("react.scope"),A=Y("react.opaque.id"),_=Y("react.debug_trace_mode"),P=Y("react.offscreen"),U=Y("react.legacy_hidden")}var Q,R="function"==typeof Symbol&&Symbol.iterator;function F(e){return null===e||"object"!=typeof e?null:"function"==typeof(e=R&&e[R]||e["@iterator"])?e:null}function V(e){if(void 0===Q)try{throw Error()}catch(e){var t=e.stack.trim().match(/\n( *(at )?)/);Q=t&&t[1]||""}return"\n"+Q+e}var B=!1;function W(e,t){if(!e||B)return"";B=!0;var n=Error.prepareStackTrace;Error.prepareStackTrace=void 0;try{if(t)if(t=function(){throw Error()},Object.defineProperty(t.prototype,"props",{set:function(){throw Error()}}),"object"==typeof Reflect&&Reflect.construct){try{Reflect.construct(t,[])}catch(e){var r=e}Reflect.construct(e,[],t)}else{try{t.call()}catch(e){r=e}e.call(t.prototype)}else{try{throw Error()}catch(e){r=e}e()}}catch(e){if(e&&r&&"string"==typeof e.stack){for(var a=e.stack.split("\n"),l=r.stack.split("\n"),o=a.length-1,i=l.length-1;1<=o&&0<=i&&a[o]!==l[i];)i--;for(;1<=o&&0<=i;o--,i--)if(a[o]!==l[i]){if(1!==o||1!==i)do{if(o--,0>--i||a[o]!==l[i])return"\n"+a[o].replace(" at new "," at ")}while(1<=o&&0<=i);break}}}finally{B=!1,Error.prepareStackTrace=n}return(e=e?e.displayName||e.name:"")?V(e):""}function H(e){switch(e.tag){case 5:return V(e.type);case 16:return V("Lazy");case 13:return V("Suspense");case 19:return V("SuspenseList");case 0:case 2:case 15:return W(e.type,!1);case 11:return W(e.type.render,!1);case 22:return W(e.type._render,!1);case 1:return W(e.type,!0);default:return""}}function K(e){if(null==e)return null;if("function"==typeof e)return e.displayName||e.name||null;if("string"==typeof e)return e;switch(e){case w:return"Fragment";case N:return"Portal";case x:return"Profiler";case S:return"StrictMode";case C:return"Suspense";case I:return"SuspenseList"}if("object"==typeof e)switch(e.$$typeof){case j:return(e.displayName||"Context")+".Consumer";case k:return(e._context.displayName||"Context")+".Provider";case T:var t=e.render;return t=t.displayName||t.name||"",e.displayName||(""!==t?"ForwardRef("+t+")":"ForwardRef");case D:return K(e.type);case z:return K(e._render);case O:t=e._payload,e=e._init;try{return K(e(t))}catch(e){}}return null}function G(e){switch(typeof e){case"boolean":case"number":case"object":case"string":case"undefined":return e;default:return""}}function $(e){var t=e.type;return(e=e.nodeName)&&"input"===e.toLowerCase()&&("checkbox"===t||"radio"===t)}function q(e){e._valueTracker||(e._valueTracker=function(e){var t=$(e)?"checked":"value",n=Object.getOwnPropertyDescriptor(e.constructor.prototype,t),r=""+e[t];if(!e.hasOwnProperty(t)&&void 0!==n&&"function"==typeof n.get&&"function"==typeof n.set){var a=n.get,l=n.set;return Object.defineProperty(e,t,{configurable:!0,get:function(){return a.call(this)},set:function(e){r=""+e,l.call(this,e)}}),Object.defineProperty(e,t,{enumerable:n.enumerable}),{getValue:function(){return r},setValue:function(e){r=""+e},stopTracking:function(){e._valueTracker=null,delete e[t]}}}}(e))}function Z(e){if(!e)return!1;var t=e._valueTracker;if(!t)return!0;var n=t.getValue(),r="";return e&&(r=$(e)?e.checked?"true":"false":e.value),(e=r)!==n&&(t.setValue(e),!0)}function X(e){if(void 0===(e=e||("undefined"!=typeof document?document:void 0)))return null;try{return e.activeElement||e.body}catch(t){return e.body}}function J(e,t){var n=t.checked;return a({},t,{defaultChecked:void 0,defaultValue:void 0,value:void 0,checked:null!=n?n:e._wrapperState.initialChecked})}function ee(e,t){var n=null==t.defaultValue?"":t.defaultValue,r=null!=t.checked?t.checked:t.defaultChecked;n=G(null!=t.value?t.value:n),e._wrapperState={initialChecked:r,initialValue:n,controlled:"checkbox"===t.type||"radio"===t.type?null!=t.checked:null!=t.value}}function te(e,t){null!=(t=t.checked)&&M(e,"checked",t,!1)}function ne(e,t){te(e,t);var n=G(t.value),r=t.type;if(null!=n)"number"===r?(0===n&&""===e.value||e.value!=n)&&(e.value=""+n):e.value!==""+n&&(e.value=""+n);else if("submit"===r||"reset"===r)return void e.removeAttribute("value");t.hasOwnProperty("value")?ae(e,t.type,n):t.hasOwnProperty("defaultValue")&&ae(e,t.type,G(t.defaultValue)),null==t.checked&&null!=t.defaultChecked&&(e.defaultChecked=!!t.defaultChecked)}function re(e,t,n){if(t.hasOwnProperty("value")||t.hasOwnProperty("defaultValue")){var r=t.type;if(!("submit"!==r&&"reset"!==r||void 0!==t.value&&null!==t.value))return;t=""+e._wrapperState.initialValue,n||t===e.value||(e.value=t),e.defaultValue=t}""!==(n=e.name)&&(e.name=""),e.defaultChecked=!!e._wrapperState.initialChecked,""!==n&&(e.name=n)}function ae(e,t,n){"number"===t&&X(e.ownerDocument)===e||(null==n?e.defaultValue=""+e._wrapperState.initialValue:e.defaultValue!==""+n&&(e.defaultValue=""+n))}function le(e,t){return e=a({children:void 0},t),(t=function(e){var t="";return r.Children.forEach(e,(function(e){null!=e&&(t+=e)})),t}(t.children))&&(e.children=t),e}function oe(e,t,n,r){if(e=e.options,t){t={};for(var a=0;a<n.length;a++)t["$"+n[a]]=!0;for(n=0;n<e.length;n++)a=t.hasOwnProperty("$"+e[n].value),e[n].selected!==a&&(e[n].selected=a),a&&r&&(e[n].defaultSelected=!0)}else{for(n=""+G(n),t=null,a=0;a<e.length;a++){if(e[a].value===n)return e[a].selected=!0,void(r&&(e[a].defaultSelected=!0));null!==t||e[a].disabled||(t=e[a])}null!==t&&(t.selected=!0)}}function ie(e,t){if(null!=t.dangerouslySetInnerHTML)throw Error(o(91));return a({},t,{value:void 0,defaultValue:void 0,children:""+e._wrapperState.initialValue})}function ue(e,t){var n=t.value;if(null==n){if(n=t.children,t=t.defaultValue,null!=n){if(null!=t)throw Error(o(92));if(Array.isArray(n)){if(!(1>=n.length))throw Error(o(93));n=n[0]}t=n}null==t&&(t=""),n=t}e._wrapperState={initialValue:G(n)}}function se(e,t){var n=G(t.value),r=G(t.defaultValue);null!=n&&((n=""+n)!==e.value&&(e.value=n),null==t.defaultValue&&e.defaultValue!==n&&(e.defaultValue=n)),null!=r&&(e.defaultValue=""+r)}function ce(e){var t=e.textContent;t===e._wrapperState.initialValue&&""!==t&&null!==t&&(e.value=t)}var fe="http://www.w3.org/1999/xhtml";function de(e){switch(e){case"svg":return"http://www.w3.org/2000/svg";case"math":return"http://www.w3.org/1998/Math/MathML";default:return"http://www.w3.org/1999/xhtml"}}function pe(e,t){return null==e||"http://www.w3.org/1999/xhtml"===e?de(t):"http://www.w3.org/2000/svg"===e&&"foreignObject"===t?"http://www.w3.org/1999/xhtml":e}var ye,he,ge=(he=function(e,t){if("http://www.w3.org/2000/svg"!==e.namespaceURI||"innerHTML"in e)e.innerHTML=t;else{for((ye=ye||document.createElement("div")).innerHTML="<svg>"+t.valueOf().toString()+"</svg>",t=ye.firstChild;e.firstChild;)e.removeChild(e.firstChild);for(;t.firstChild;)e.appendChild(t.firstChild)}},"undefined"!=typeof MSApp&&MSApp.execUnsafeLocalFunction?function(e,t,n,r){MSApp.execUnsafeLocalFunction((function(){return he(e,t)}))}:he);function me(e,t){if(t){var n=e.firstChild;if(n&&n===e.lastChild&&3===n.nodeType)return void(n.nodeValue=t)}e.textContent=t}var ve={animationIterationCount:!0,borderImageOutset:!0,borderImageSlice:!0,borderImageWidth:!0,boxFlex:!0,boxFlexGroup:!0,boxOrdinalGroup:!0,columnCount:!0,columns:!0,flex:!0,flexGrow:!0,flexPositive:!0,flexShrink:!0,flexNegative:!0,flexOrder:!0,gridArea:!0,gridRow:!0,gridRowEnd:!0,gridRowSpan:!0,gridRowStart:!0,gridColumn:!0,gridColumnEnd:!0,gridColumnSpan:!0,gridColumnStart:!0,fontWeight:!0,lineClamp:!0,lineHeight:!0,opacity:!0,order:!0,orphans:!0,tabSize:!0,widows:!0,zIndex:!0,zoom:!0,fillOpacity:!0,floodOpacity:!0,stopOpacity:!0,strokeDasharray:!0,strokeDashoffset:!0,strokeMiterlimit:!0,strokeOpacity:!0,strokeWidth:!0},be=["Webkit","ms","Moz","O"];function Me(e,t,n){return null==t||"boolean"==typeof t||""===t?"":n||"number"!=typeof t||0===t||ve.hasOwnProperty(e)&&ve[e]?(""+t).trim():t+"px"}function Ee(e,t){for(var n in e=e.style,t)if(t.hasOwnProperty(n)){var r=0===n.indexOf("--"),a=Me(n,t[n],r);"float"===n&&(n="cssFloat"),r?e.setProperty(n,a):e[n]=a}}Object.keys(ve).forEach((function(e){be.forEach((function(t){t=t+e.charAt(0).toUpperCase()+e.substring(1),ve[t]=ve[e]}))}));var Le=a({menuitem:!0},{area:!0,base:!0,br:!0,col:!0,embed:!0,hr:!0,img:!0,input:!0,keygen:!0,link:!0,meta:!0,param:!0,source:!0,track:!0,wbr:!0});function Ne(e,t){if(t){if(Le[e]&&(null!=t.children||null!=t.dangerouslySetInnerHTML))throw Error(o(137,e));if(null!=t.dangerouslySetInnerHTML){if(null!=t.children)throw Error(o(60));if("object"!=typeof t.dangerouslySetInnerHTML||!("__html"in t.dangerouslySetInnerHTML))throw Error(o(61))}if(null!=t.style&&"object"!=typeof t.style)throw Error(o(62))}}function we(e,t){if(-1===e.indexOf("-"))return"string"==typeof t.is;switch(e){case"annotation-xml":case"color-profile":case"font-face":case"font-face-src":case"font-face-uri":case"font-face-format":case"font-face-name":case"missing-glyph":return!1;default:return!0}}function Se(e){return(e=e.target||e.srcElement||window).correspondingUseElement&&(e=e.correspondingUseElement),3===e.nodeType?e.parentNode:e}var xe=null,ke=null,je=null;function Te(e){if(e=Jr(e)){if("function"!=typeof xe)throw Error(o(280));var t=e.stateNode;t&&(t=ta(t),xe(e.stateNode,e.type,t))}}function Ce(e){ke?je?je.push(e):je=[e]:ke=e}function Ie(){if(ke){var e=ke,t=je;if(je=ke=null,Te(e),t)for(e=0;e<t.length;e++)Te(t[e])}}function De(e,t){return e(t)}function Oe(e,t,n,r,a){return e(t,n,r,a)}function ze(){}var Ae=De,_e=!1,Pe=!1;function Ue(){null===ke&&null===je||(ze(),Ie())}function Ye(e,t){var n=e.stateNode;if(null===n)return null;var r=ta(n);if(null===r)return null;n=r[t];e:switch(t){case"onClick":case"onClickCapture":case"onDoubleClick":case"onDoubleClickCapture":case"onMouseDown":case"onMouseDownCapture":case"onMouseMove":case"onMouseMoveCapture":case"onMouseUp":case"onMouseUpCapture":case"onMouseEnter":(r=!r.disabled)||(r=!("button"===(e=e.type)||"input"===e||"select"===e||"textarea"===e)),e=!r;break e;default:e=!1}if(e)return null;if(n&&"function"!=typeof n)throw Error(o(231,t,typeof n));return n}var Qe=!1;if(f)try{var Re={};Object.defineProperty(Re,"passive",{get:function(){Qe=!0}}),window.addEventListener("test",Re,Re),window.removeEventListener("test",Re,Re)}catch(he){Qe=!1}function Fe(e,t,n,r,a,l,o,i,u){var s=Array.prototype.slice.call(arguments,3);try{t.apply(n,s)}catch(e){this.onError(e)}}var Ve=!1,Be=null,We=!1,He=null,Ke={onError:function(e){Ve=!0,Be=e}};function Ge(e,t,n,r,a,l,o,i,u){Ve=!1,Be=null,Fe.apply(Ke,arguments)}function $e(e){var t=e,n=e;if(e.alternate)for(;t.return;)t=t.return;else{e=t;do{0!=(1026&(t=e).flags)&&(n=t.return),e=t.return}while(e)}return 3===t.tag?n:null}function qe(e){if(13===e.tag){var t=e.memoizedState;if(null===t&&null!==(e=e.alternate)&&(t=e.memoizedState),null!==t)return t.dehydrated}return null}function Ze(e){if($e(e)!==e)throw Error(o(188))}function Xe(e){if(!(e=function(e){var t=e.alternate;if(!t){if(null===(t=$e(e)))throw Error(o(188));return t!==e?null:e}for(var n=e,r=t;;){var a=n.return;if(null===a)break;var l=a.alternate;if(null===l){if(null!==(r=a.return)){n=r;continue}break}if(a.child===l.child){for(l=a.child;l;){if(l===n)return Ze(a),e;if(l===r)return Ze(a),t;l=l.sibling}throw Error(o(188))}if(n.return!==r.return)n=a,r=l;else{for(var i=!1,u=a.child;u;){if(u===n){i=!0,n=a,r=l;break}if(u===r){i=!0,r=a,n=l;break}u=u.sibling}if(!i){for(u=l.child;u;){if(u===n){i=!0,n=l,r=a;break}if(u===r){i=!0,r=l,n=a;break}u=u.sibling}if(!i)throw Error(o(189))}}if(n.alternate!==r)throw Error(o(190))}if(3!==n.tag)throw Error(o(188));return n.stateNode.current===n?e:t}(e)))return null;for(var t=e;;){if(5===t.tag||6===t.tag)return t;if(t.child)t.child.return=t,t=t.child;else{if(t===e)break;for(;!t.sibling;){if(!t.return||t.return===e)return null;t=t.return}t.sibling.return=t.return,t=t.sibling}}return null}function Je(e,t){for(var n=e.alternate;null!==t;){if(t===e||t===n)return!0;t=t.return}return!1}var et,tt,nt,rt,at=!1,lt=[],ot=null,it=null,ut=null,st=new Map,ct=new Map,ft=[],dt="mousedown mouseup touchcancel touchend touchstart auxclick dblclick pointercancel pointerdown pointerup dragend dragstart drop compositionend compositionstart keydown keypress keyup input textInput copy cut paste click change contextmenu reset submit".split(" ");function pt(e,t,n,r,a){return{blockedOn:e,domEventName:t,eventSystemFlags:16|n,nativeEvent:a,targetContainers:[r]}}function yt(e,t){switch(e){case"focusin":case"focusout":ot=null;break;case"dragenter":case"dragleave":it=null;break;case"mouseover":case"mouseout":ut=null;break;case"pointerover":case"pointerout":st.delete(t.pointerId);break;case"gotpointercapture":case"lostpointercapture":ct.delete(t.pointerId)}}function ht(e,t,n,r,a,l){return null===e||e.nativeEvent!==l?(e=pt(t,n,r,a,l),null!==t&&null!==(t=Jr(t))&&tt(t),e):(e.eventSystemFlags|=r,t=e.targetContainers,null!==a&&-1===t.indexOf(a)&&t.push(a),e)}function gt(e){var t=Xr(e.target);if(null!==t){var n=$e(t);if(null!==n)if(13===(t=n.tag)){if(null!==(t=qe(n)))return e.blockedOn=t,void rt(e.lanePriority,(function(){l.unstable_runWithPriority(e.priority,(function(){nt(n)}))}))}else if(3===t&&n.stateNode.hydrate)return void(e.blockedOn=3===n.tag?n.stateNode.containerInfo:null)}e.blockedOn=null}function mt(e){if(null!==e.blockedOn)return!1;for(var t=e.targetContainers;0<t.length;){var n=Xt(e.domEventName,e.eventSystemFlags,t[0],e.nativeEvent);if(null!==n)return null!==(t=Jr(n))&&tt(t),e.blockedOn=n,!1;t.shift()}return!0}function vt(e,t,n){mt(e)&&n.delete(t)}function bt(){for(at=!1;0<lt.length;){var e=lt[0];if(null!==e.blockedOn){null!==(e=Jr(e.blockedOn))&&et(e);break}for(var t=e.targetContainers;0<t.length;){var n=Xt(e.domEventName,e.eventSystemFlags,t[0],e.nativeEvent);if(null!==n){e.blockedOn=n;break}t.shift()}null===e.blockedOn&&lt.shift()}null!==ot&&mt(ot)&&(ot=null),null!==it&&mt(it)&&(it=null),null!==ut&&mt(ut)&&(ut=null),st.forEach(vt),ct.forEach(vt)}function Mt(e,t){e.blockedOn===t&&(e.blockedOn=null,at||(at=!0,l.unstable_scheduleCallback(l.unstable_NormalPriority,bt)))}function Et(e){function t(t){return Mt(t,e)}if(0<lt.length){Mt(lt[0],e);for(var n=1;n<lt.length;n++){var r=lt[n];r.blockedOn===e&&(r.blockedOn=null)}}for(null!==ot&&Mt(ot,e),null!==it&&Mt(it,e),null!==ut&&Mt(ut,e),st.forEach(t),ct.forEach(t),n=0;n<ft.length;n++)(r=ft[n]).blockedOn===e&&(r.blockedOn=null);for(;0<ft.length&&null===(n=ft[0]).blockedOn;)gt(n),null===n.blockedOn&&ft.shift()}function Lt(e,t){var n={};return n[e.toLowerCase()]=t.toLowerCase(),n["Webkit"+e]="webkit"+t,n["Moz"+e]="moz"+t,n}var Nt={animationend:Lt("Animation","AnimationEnd"),animationiteration:Lt("Animation","AnimationIteration"),animationstart:Lt("Animation","AnimationStart"),transitionend:Lt("Transition","TransitionEnd")},wt={},St={};function xt(e){if(wt[e])return wt[e];if(!Nt[e])return e;var t,n=Nt[e];for(t in n)if(n.hasOwnProperty(t)&&t in St)return wt[e]=n[t];return e}f&&(St=document.createElement("div").style,"AnimationEvent"in window||(delete Nt.animationend.animation,delete Nt.animationiteration.animation,delete Nt.animationstart.animation),"TransitionEvent"in window||delete Nt.transitionend.transition);var kt=xt("animationend"),jt=xt("animationiteration"),Tt=xt("animationstart"),Ct=xt("transitionend"),It=new Map,Dt=new Map,Ot=["abort","abort",kt,"animationEnd",jt,"animationIteration",Tt,"animationStart","canplay","canPlay","canplaythrough","canPlayThrough","durationchange","durationChange","emptied","emptied","encrypted","encrypted","ended","ended","error","error","gotpointercapture","gotPointerCapture","load","load","loadeddata","loadedData","loadedmetadata","loadedMetadata","loadstart","loadStart","lostpointercapture","lostPointerCapture","playing","playing","progress","progress","seeking","seeking","stalled","stalled","suspend","suspend","timeupdate","timeUpdate",Ct,"transitionEnd","waiting","waiting"];function zt(e,t){for(var n=0;n<e.length;n+=2){var r=e[n],a=e[n+1];a="on"+(a[0].toUpperCase()+a.slice(1)),Dt.set(r,t),It.set(r,a),s(a,[r])}}(0,l.unstable_now)();var At=8;function _t(e){if(0!=(1&e))return At=15,1;if(0!=(2&e))return At=14,2;if(0!=(4&e))return At=13,4;var t=24&e;return 0!==t?(At=12,t):0!=(32&e)?(At=11,32):0!=(t=192&e)?(At=10,t):0!=(256&e)?(At=9,256):0!=(t=3584&e)?(At=8,t):0!=(4096&e)?(At=7,4096):0!=(t=4186112&e)?(At=6,t):0!=(t=62914560&e)?(At=5,t):67108864&e?(At=4,67108864):0!=(134217728&e)?(At=3,134217728):0!=(t=805306368&e)?(At=2,t):0!=(1073741824&e)?(At=1,1073741824):(At=8,e)}function Pt(e,t){var n=e.pendingLanes;if(0===n)return At=0;var r=0,a=0,l=e.expiredLanes,o=e.suspendedLanes,i=e.pingedLanes;if(0!==l)r=l,a=At=15;else if(0!=(l=134217727&n)){var u=l&~o;0!==u?(r=_t(u),a=At):0!=(i&=l)&&(r=_t(i),a=At)}else 0!=(l=n&~o)?(r=_t(l),a=At):0!==i&&(r=_t(i),a=At);if(0===r)return 0;if(r=n&((0>(r=31-Vt(r))?0:1<<r)<<1)-1,0!==t&&t!==r&&0==(t&o)){if(_t(t),a<=At)return t;At=a}if(0!==(t=e.entangledLanes))for(e=e.entanglements,t&=r;0<t;)a=1<<(n=31-Vt(t)),r|=e[n],t&=~a;return r}function Ut(e){return 0!=(e=-1073741825&e.pendingLanes)?e:1073741824&e?1073741824:0}function Yt(e,t){switch(e){case 15:return 1;case 14:return 2;case 12:return 0===(e=Qt(24&~t))?Yt(10,t):e;case 10:return 0===(e=Qt(192&~t))?Yt(8,t):e;case 8:return 0===(e=Qt(3584&~t))&&0===(e=Qt(4186112&~t))&&(e=512),e;case 2:return 0===(t=Qt(805306368&~t))&&(t=268435456),t}throw Error(o(358,e))}function Qt(e){return e&-e}function Rt(e){for(var t=[],n=0;31>n;n++)t.push(e);return t}function Ft(e,t,n){e.pendingLanes|=t;var r=t-1;e.suspendedLanes&=r,e.pingedLanes&=r,(e=e.eventTimes)[t=31-Vt(t)]=n}var Vt=Math.clz32?Math.clz32:function(e){return 0===e?32:31-(Bt(e)/Wt|0)|0},Bt=Math.log,Wt=Math.LN2,Ht=l.unstable_UserBlockingPriority,Kt=l.unstable_runWithPriority,Gt=!0;function $t(e,t,n,r){_e||ze();var a=Zt,l=_e;_e=!0;try{Oe(a,e,t,n,r)}finally{(_e=l)||Ue()}}function qt(e,t,n,r){Kt(Ht,Zt.bind(null,e,t,n,r))}function Zt(e,t,n,r){var a;if(Gt)if((a=0==(4&t))&&0<lt.length&&-1<dt.indexOf(e))e=pt(null,e,t,n,r),lt.push(e);else{var l=Xt(e,t,n,r);if(null===l)a&&yt(e,r);else{if(a){if(-1<dt.indexOf(e))return e=pt(l,e,t,n,r),void lt.push(e);if(function(e,t,n,r,a){switch(t){case"focusin":return ot=ht(ot,e,t,n,r,a),!0;case"dragenter":return it=ht(it,e,t,n,r,a),!0;case"mouseover":return ut=ht(ut,e,t,n,r,a),!0;case"pointerover":var l=a.pointerId;return st.set(l,ht(st.get(l)||null,e,t,n,r,a)),!0;case"gotpointercapture":return l=a.pointerId,ct.set(l,ht(ct.get(l)||null,e,t,n,r,a)),!0}return!1}(l,e,t,n,r))return;yt(e,r)}Ir(e,t,r,null,n)}}}function Xt(e,t,n,r){var a=Se(r);if(null!==(a=Xr(a))){var l=$e(a);if(null===l)a=null;else{var o=l.tag;if(13===o){if(null!==(a=qe(l)))return a;a=null}else if(3===o){if(l.stateNode.hydrate)return 3===l.tag?l.stateNode.containerInfo:null;a=null}else l!==a&&(a=null)}}return Ir(e,t,r,a,n),null}var Jt=null,en=null,tn=null;function nn(){if(tn)return tn;var e,t,n=en,r=n.length,a="value"in Jt?Jt.value:Jt.textContent,l=a.length;for(e=0;e<r&&n[e]===a[e];e++);var o=r-e;for(t=1;t<=o&&n[r-t]===a[l-t];t++);return tn=a.slice(e,1<t?1-t:void 0)}function rn(e){var t=e.keyCode;return"charCode"in e?0===(e=e.charCode)&&13===t&&(e=13):e=t,10===e&&(e=13),32<=e||13===e?e:0}function an(){return!0}function ln(){return!1}function on(e){function t(t,n,r,a,l){for(var o in this._reactName=t,this._targetInst=r,this.type=n,this.nativeEvent=a,this.target=l,this.currentTarget=null,e)e.hasOwnProperty(o)&&(t=e[o],this[o]=t?t(a):a[o]);return this.isDefaultPrevented=(null!=a.defaultPrevented?a.defaultPrevented:!1===a.returnValue)?an:ln,this.isPropagationStopped=ln,this}return a(t.prototype,{preventDefault:function(){this.defaultPrevented=!0;var e=this.nativeEvent;e&&(e.preventDefault?e.preventDefault():"unknown"!=typeof e.returnValue&&(e.returnValue=!1),this.isDefaultPrevented=an)},stopPropagation:function(){var e=this.nativeEvent;e&&(e.stopPropagation?e.stopPropagation():"unknown"!=typeof e.cancelBubble&&(e.cancelBubble=!0),this.isPropagationStopped=an)},persist:function(){},isPersistent:an}),t}var un,sn,cn,fn={eventPhase:0,bubbles:0,cancelable:0,timeStamp:function(e){return e.timeStamp||Date.now()},defaultPrevented:0,isTrusted:0},dn=on(fn),pn=a({},fn,{view:0,detail:0}),yn=on(pn),hn=a({},pn,{screenX:0,screenY:0,clientX:0,clientY:0,pageX:0,pageY:0,ctrlKey:0,shiftKey:0,altKey:0,metaKey:0,getModifierState:xn,button:0,buttons:0,relatedTarget:function(e){return void 0===e.relatedTarget?e.fromElement===e.srcElement?e.toElement:e.fromElement:e.relatedTarget},movementX:function(e){return"movementX"in e?e.movementX:(e!==cn&&(cn&&"mousemove"===e.type?(un=e.screenX-cn.screenX,sn=e.screenY-cn.screenY):sn=un=0,cn=e),un)},movementY:function(e){return"movementY"in e?e.movementY:sn}}),gn=on(hn),mn=on(a({},hn,{dataTransfer:0})),vn=on(a({},pn,{relatedTarget:0})),bn=on(a({},fn,{animationName:0,elapsedTime:0,pseudoElement:0})),Mn=on(a({},fn,{clipboardData:function(e){return"clipboardData"in e?e.clipboardData:window.clipboardData}})),En=on(a({},fn,{data:0})),Ln={Esc:"Escape",Spacebar:" ",Left:"ArrowLeft",Up:"ArrowUp",Right:"ArrowRight",Down:"ArrowDown",Del:"Delete",Win:"OS",Menu:"ContextMenu",Apps:"ContextMenu",Scroll:"ScrollLock",MozPrintableKey:"Unidentified"},Nn={8:"Backspace",9:"Tab",12:"Clear",13:"Enter",16:"Shift",17:"Control",18:"Alt",19:"Pause",20:"CapsLock",27:"Escape",32:" ",33:"PageUp",34:"PageDown",35:"End",36:"Home",37:"ArrowLeft",38:"ArrowUp",39:"ArrowRight",40:"ArrowDown",45:"Insert",46:"Delete",112:"F1",113:"F2",114:"F3",115:"F4",116:"F5",117:"F6",118:"F7",119:"F8",120:"F9",121:"F10",122:"F11",123:"F12",144:"NumLock",145:"ScrollLock",224:"Meta"},wn={Alt:"altKey",Control:"ctrlKey",Meta:"metaKey",Shift:"shiftKey"};function Sn(e){var t=this.nativeEvent;return t.getModifierState?t.getModifierState(e):!!(e=wn[e])&&!!t[e]}function xn(){return Sn}var kn=on(a({},pn,{key:function(e){if(e.key){var t=Ln[e.key]||e.key;if("Unidentified"!==t)return t}return"keypress"===e.type?13===(e=rn(e))?"Enter":String.fromCharCode(e):"keydown"===e.type||"keyup"===e.type?Nn[e.keyCode]||"Unidentified":""},code:0,location:0,ctrlKey:0,shiftKey:0,altKey:0,metaKey:0,repeat:0,locale:0,getModifierState:xn,charCode:function(e){return"keypress"===e.type?rn(e):0},keyCode:function(e){return"keydown"===e.type||"keyup"===e.type?e.keyCode:0},which:function(e){return"keypress"===e.type?rn(e):"keydown"===e.type||"keyup"===e.type?e.keyCode:0}})),jn=on(a({},hn,{pointerId:0,width:0,height:0,pressure:0,tangentialPressure:0,tiltX:0,tiltY:0,twist:0,pointerType:0,isPrimary:0})),Tn=on(a({},pn,{touches:0,targetTouches:0,changedTouches:0,altKey:0,metaKey:0,ctrlKey:0,shiftKey:0,getModifierState:xn})),Cn=on(a({},fn,{propertyName:0,elapsedTime:0,pseudoElement:0})),In=on(a({},hn,{deltaX:function(e){return"deltaX"in e?e.deltaX:"wheelDeltaX"in e?-e.wheelDeltaX:0},deltaY:function(e){return"deltaY"in e?e.deltaY:"wheelDeltaY"in e?-e.wheelDeltaY:"wheelDelta"in e?-e.wheelDelta:0},deltaZ:0,deltaMode:0})),Dn=[9,13,27,32],On=f&&"CompositionEvent"in window,zn=null;f&&"documentMode"in document&&(zn=document.documentMode);var An=f&&"TextEvent"in window&&!zn,_n=f&&(!On||zn&&8<zn&&11>=zn),Pn=String.fromCharCode(32),Un=!1;function Yn(e,t){switch(e){case"keyup":return-1!==Dn.indexOf(t.keyCode);case"keydown":return 229!==t.keyCode;case"keypress":case"mousedown":case"focusout":return!0;default:return!1}}function Qn(e){return"object"==typeof(e=e.detail)&&"data"in e?e.data:null}var Rn=!1,Fn={color:!0,date:!0,datetime:!0,"datetime-local":!0,email:!0,month:!0,number:!0,password:!0,range:!0,search:!0,tel:!0,text:!0,time:!0,url:!0,week:!0};function Vn(e){var t=e&&e.nodeName&&e.nodeName.toLowerCase();return"input"===t?!!Fn[e.type]:"textarea"===t}function Bn(e,t,n,r){Ce(r),0<(t=Or(t,"onChange")).length&&(n=new dn("onChange","change",null,n,r),e.push({event:n,listeners:t}))}var Wn=null,Hn=null;function Kn(e){Sr(e,0)}function Gn(e){if(Z(ea(e)))return e}function $n(e,t){if("change"===e)return t}var qn=!1;if(f){var Zn;if(f){var Xn="oninput"in document;if(!Xn){var Jn=document.createElement("div");Jn.setAttribute("oninput","return;"),Xn="function"==typeof Jn.oninput}Zn=Xn}else Zn=!1;qn=Zn&&(!document.documentMode||9<document.documentMode)}function er(){Wn&&(Wn.detachEvent("onpropertychange",tr),Hn=Wn=null)}function tr(e){if("value"===e.propertyName&&Gn(Hn)){var t=[];if(Bn(t,Hn,e,Se(e)),e=Kn,_e)e(t);else{_e=!0;try{De(e,t)}finally{_e=!1,Ue()}}}}function nr(e,t,n){"focusin"===e?(er(),Hn=n,(Wn=t).attachEvent("onpropertychange",tr)):"focusout"===e&&er()}function rr(e){if("selectionchange"===e||"keyup"===e||"keydown"===e)return Gn(Hn)}function ar(e,t){if("click"===e)return Gn(t)}function lr(e,t){if("input"===e||"change"===e)return Gn(t)}var or="function"==typeof Object.is?Object.is:function(e,t){return e===t&&(0!==e||1/e==1/t)||e!=e&&t!=t},ir=Object.prototype.hasOwnProperty;function ur(e,t){if(or(e,t))return!0;if("object"!=typeof e||null===e||"object"!=typeof t||null===t)return!1;var n=Object.keys(e),r=Object.keys(t);if(n.length!==r.length)return!1;for(r=0;r<n.length;r++)if(!ir.call(t,n[r])||!or(e[n[r]],t[n[r]]))return!1;return!0}function sr(e){for(;e&&e.firstChild;)e=e.firstChild;return e}function cr(e,t){var n,r=sr(e);for(e=0;r;){if(3===r.nodeType){if(n=e+r.textContent.length,e<=t&&n>=t)return{node:r,offset:t-e};e=n}e:{for(;r;){if(r.nextSibling){r=r.nextSibling;break e}r=r.parentNode}r=void 0}r=sr(r)}}function fr(e,t){return!(!e||!t)&&(e===t||(!e||3!==e.nodeType)&&(t&&3===t.nodeType?fr(e,t.parentNode):"contains"in e?e.contains(t):!!e.compareDocumentPosition&&!!(16&e.compareDocumentPosition(t))))}function dr(){for(var e=window,t=X();t instanceof e.HTMLIFrameElement;){try{var n="string"==typeof t.contentWindow.location.href}catch(e){n=!1}if(!n)break;t=X((e=t.contentWindow).document)}return t}function pr(e){var t=e&&e.nodeName&&e.nodeName.toLowerCase();return t&&("input"===t&&("text"===e.type||"search"===e.type||"tel"===e.type||"url"===e.type||"password"===e.type)||"textarea"===t||"true"===e.contentEditable)}var yr=f&&"documentMode"in document&&11>=document.documentMode,hr=null,gr=null,mr=null,vr=!1;function br(e,t,n){var r=n.window===n?n.document:9===n.nodeType?n:n.ownerDocument;vr||null==hr||hr!==X(r)||(r="selectionStart"in(r=hr)&&pr(r)?{start:r.selectionStart,end:r.selectionEnd}:{anchorNode:(r=(r.ownerDocument&&r.ownerDocument.defaultView||window).getSelection()).anchorNode,anchorOffset:r.anchorOffset,focusNode:r.focusNode,focusOffset:r.focusOffset},mr&&ur(mr,r)||(mr=r,0<(r=Or(gr,"onSelect")).length&&(t=new dn("onSelect","select",null,t,n),e.push({event:t,listeners:r}),t.target=hr)))}zt("cancel cancel click click close close contextmenu contextMenu copy copy cut cut auxclick auxClick dblclick doubleClick dragend dragEnd dragstart dragStart drop drop focusin focus focusout blur input input invalid invalid keydown keyDown keypress keyPress keyup keyUp mousedown mouseDown mouseup mouseUp paste paste pause pause play play pointercancel pointerCancel pointerdown pointerDown pointerup pointerUp ratechange rateChange reset reset seeked seeked submit submit touchcancel touchCancel touchend touchEnd touchstart touchStart volumechange volumeChange".split(" "),0),zt("drag drag dragenter dragEnter dragexit dragExit dragleave dragLeave dragover dragOver mousemove mouseMove mouseout mouseOut mouseover mouseOver pointermove pointerMove pointerout pointerOut pointerover pointerOver scroll scroll toggle toggle touchmove touchMove wheel wheel".split(" "),1),zt(Ot,2);for(var Mr="change selectionchange textInput compositionstart compositionend compositionupdate".split(" "),Er=0;Er<Mr.length;Er++)Dt.set(Mr[Er],0);c("onMouseEnter",["mouseout","mouseover"]),c("onMouseLeave",["mouseout","mouseover"]),c("onPointerEnter",["pointerout","pointerover"]),c("onPointerLeave",["pointerout","pointerover"]),s("onChange","change click focusin focusout input keydown keyup selectionchange".split(" ")),s("onSelect","focusout contextmenu dragend focusin keydown keyup mousedown mouseup selectionchange".split(" ")),s("onBeforeInput",["compositionend","keypress","textInput","paste"]),s("onCompositionEnd","compositionend focusout keydown keypress keyup mousedown".split(" ")),s("onCompositionStart","compositionstart focusout keydown keypress keyup mousedown".split(" ")),s("onCompositionUpdate","compositionupdate focusout keydown keypress keyup mousedown".split(" "));var Lr="abort canplay canplaythrough durationchange emptied encrypted ended error loadeddata loadedmetadata loadstart pause play playing progress ratechange seeked seeking stalled suspend timeupdate volumechange waiting".split(" "),Nr=new Set("cancel close invalid load scroll toggle".split(" ").concat(Lr));function wr(e,t,n){var r=e.type||"unknown-event";e.currentTarget=n,function(e,t,n,r,a,l,i,u,s){if(Ge.apply(this,arguments),Ve){if(!Ve)throw Error(o(198));var c=Be;Ve=!1,Be=null,We||(We=!0,He=c)}}(r,t,void 0,e),e.currentTarget=null}function Sr(e,t){t=0!=(4&t);for(var n=0;n<e.length;n++){var r=e[n],a=r.event;r=r.listeners;e:{var l=void 0;if(t)for(var o=r.length-1;0<=o;o--){var i=r[o],u=i.instance,s=i.currentTarget;if(i=i.listener,u!==l&&a.isPropagationStopped())break e;wr(a,i,s),l=u}else for(o=0;o<r.length;o++){if(u=(i=r[o]).instance,s=i.currentTarget,i=i.listener,u!==l&&a.isPropagationStopped())break e;wr(a,i,s),l=u}}}if(We)throw e=He,We=!1,He=null,e}function xr(e,t){var n=na(t),r=e+"__bubble";n.has(r)||(Cr(t,e,2,!1),n.add(r))}var kr="_reactListening"+Math.random().toString(36).slice(2);function jr(e){e[kr]||(e[kr]=!0,i.forEach((function(t){Nr.has(t)||Tr(t,!1,e,null),Tr(t,!0,e,null)})))}function Tr(e,t,n,r){var a=4<arguments.length&&void 0!==arguments[4]?arguments[4]:0,l=n;if("selectionchange"===e&&9!==n.nodeType&&(l=n.ownerDocument),null!==r&&!t&&Nr.has(e)){if("scroll"!==e)return;a|=2,l=r}var o=na(l),i=e+"__"+(t?"capture":"bubble");o.has(i)||(t&&(a|=4),Cr(l,e,a,t),o.add(i))}function Cr(e,t,n,r){var a=Dt.get(t);switch(void 0===a?2:a){case 0:a=$t;break;case 1:a=qt;break;default:a=Zt}n=a.bind(null,t,n,e),a=void 0,!Qe||"touchstart"!==t&&"touchmove"!==t&&"wheel"!==t||(a=!0),r?void 0!==a?e.addEventListener(t,n,{capture:!0,passive:a}):e.addEventListener(t,n,!0):void 0!==a?e.addEventListener(t,n,{passive:a}):e.addEventListener(t,n,!1)}function Ir(e,t,n,r,a){var l=r;if(0==(1&t)&&0==(2&t)&&null!==r)e:for(;;){if(null===r)return;var o=r.tag;if(3===o||4===o){var i=r.stateNode.containerInfo;if(i===a||8===i.nodeType&&i.parentNode===a)break;if(4===o)for(o=r.return;null!==o;){var u=o.tag;if((3===u||4===u)&&((u=o.stateNode.containerInfo)===a||8===u.nodeType&&u.parentNode===a))return;o=o.return}for(;null!==i;){if(null===(o=Xr(i)))return;if(5===(u=o.tag)||6===u){r=l=o;continue e}i=i.parentNode}}r=r.return}!function(e,t,n){if(Pe)return e();Pe=!0;try{Ae(e,t,n)}finally{Pe=!1,Ue()}}((function(){var r=l,a=Se(n),o=[];e:{var i=It.get(e);if(void 0!==i){var u=dn,s=e;switch(e){case"keypress":if(0===rn(n))break e;case"keydown":case"keyup":u=kn;break;case"focusin":s="focus",u=vn;break;case"focusout":s="blur",u=vn;break;case"beforeblur":case"afterblur":u=vn;break;case"click":if(2===n.button)break e;case"auxclick":case"dblclick":case"mousedown":case"mousemove":case"mouseup":case"mouseout":case"mouseover":case"contextmenu":u=gn;break;case"drag":case"dragend":case"dragenter":case"dragexit":case"dragleave":case"dragover":case"dragstart":case"drop":u=mn;break;case"touchcancel":case"touchend":case"touchmove":case"touchstart":u=Tn;break;case kt:case jt:case Tt:u=bn;break;case Ct:u=Cn;break;case"scroll":u=yn;break;case"wheel":u=In;break;case"copy":case"cut":case"paste":u=Mn;break;case"gotpointercapture":case"lostpointercapture":case"pointercancel":case"pointerdown":case"pointermove":case"pointerout":case"pointerover":case"pointerup":u=jn}var c=0!=(4&t),f=!c&&"scroll"===e,d=c?null!==i?i+"Capture":null:i;c=[];for(var p,y=r;null!==y;){var h=(p=y).stateNode;if(5===p.tag&&null!==h&&(p=h,null!==d&&null!=(h=Ye(y,d))&&c.push(Dr(y,h,p))),f)break;y=y.return}0<c.length&&(i=new u(i,s,null,n,a),o.push({event:i,listeners:c}))}}if(0==(7&t)){if(u="mouseout"===e||"pointerout"===e,(!(i="mouseover"===e||"pointerover"===e)||0!=(16&t)||!(s=n.relatedTarget||n.fromElement)||!Xr(s)&&!s[qr])&&(u||i)&&(i=a.window===a?a:(i=a.ownerDocument)?i.defaultView||i.parentWindow:window,u?(u=r,null!==(s=(s=n.relatedTarget||n.toElement)?Xr(s):null)&&(s!==(f=$e(s))||5!==s.tag&&6!==s.tag)&&(s=null)):(u=null,s=r),u!==s)){if(c=gn,h="onMouseLeave",d="onMouseEnter",y="mouse","pointerout"!==e&&"pointerover"!==e||(c=jn,h="onPointerLeave",d="onPointerEnter",y="pointer"),f=null==u?i:ea(u),p=null==s?i:ea(s),(i=new c(h,y+"leave",u,n,a)).target=f,i.relatedTarget=p,h=null,Xr(a)===r&&((c=new c(d,y+"enter",s,n,a)).target=p,c.relatedTarget=f,h=c),f=h,u&&s)e:{for(d=s,y=0,p=c=u;p;p=zr(p))y++;for(p=0,h=d;h;h=zr(h))p++;for(;0<y-p;)c=zr(c),y--;for(;0<p-y;)d=zr(d),p--;for(;y--;){if(c===d||null!==d&&c===d.alternate)break e;c=zr(c),d=zr(d)}c=null}else c=null;null!==u&&Ar(o,i,u,c,!1),null!==s&&null!==f&&Ar(o,f,s,c,!0)}if("select"===(u=(i=r?ea(r):window).nodeName&&i.nodeName.toLowerCase())||"input"===u&&"file"===i.type)var g=$n;else if(Vn(i))if(qn)g=lr;else{g=rr;var m=nr}else(u=i.nodeName)&&"input"===u.toLowerCase()&&("checkbox"===i.type||"radio"===i.type)&&(g=ar);switch(g&&(g=g(e,r))?Bn(o,g,n,a):(m&&m(e,i,r),"focusout"===e&&(m=i._wrapperState)&&m.controlled&&"number"===i.type&&ae(i,"number",i.value)),m=r?ea(r):window,e){case"focusin":(Vn(m)||"true"===m.contentEditable)&&(hr=m,gr=r,mr=null);break;case"focusout":mr=gr=hr=null;break;case"mousedown":vr=!0;break;case"contextmenu":case"mouseup":case"dragend":vr=!1,br(o,n,a);break;case"selectionchange":if(yr)break;case"keydown":case"keyup":br(o,n,a)}var v;if(On)e:{switch(e){case"compositionstart":var b="onCompositionStart";break e;case"compositionend":b="onCompositionEnd";break e;case"compositionupdate":b="onCompositionUpdate";break e}b=void 0}else Rn?Yn(e,n)&&(b="onCompositionEnd"):"keydown"===e&&229===n.keyCode&&(b="onCompositionStart");b&&(_n&&"ko"!==n.locale&&(Rn||"onCompositionStart"!==b?"onCompositionEnd"===b&&Rn&&(v=nn()):(en="value"in(Jt=a)?Jt.value:Jt.textContent,Rn=!0)),0<(m=Or(r,b)).length&&(b=new En(b,e,null,n,a),o.push({event:b,listeners:m}),(v||null!==(v=Qn(n)))&&(b.data=v))),(v=An?function(e,t){switch(e){case"compositionend":return Qn(t);case"keypress":return 32!==t.which?null:(Un=!0,Pn);case"textInput":return(e=t.data)===Pn&&Un?null:e;default:return null}}(e,n):function(e,t){if(Rn)return"compositionend"===e||!On&&Yn(e,t)?(e=nn(),tn=en=Jt=null,Rn=!1,e):null;switch(e){case"paste":return null;case"keypress":if(!(t.ctrlKey||t.altKey||t.metaKey)||t.ctrlKey&&t.altKey){if(t.char&&1<t.char.length)return t.char;if(t.which)return String.fromCharCode(t.which)}return null;case"compositionend":return _n&&"ko"!==t.locale?null:t.data;default:return null}}(e,n))&&0<(r=Or(r,"onBeforeInput")).length&&(a=new En("onBeforeInput","beforeinput",null,n,a),o.push({event:a,listeners:r}),a.data=v)}Sr(o,t)}))}function Dr(e,t,n){return{instance:e,listener:t,currentTarget:n}}function Or(e,t){for(var n=t+"Capture",r=[];null!==e;){var a=e,l=a.stateNode;5===a.tag&&null!==l&&(a=l,null!=(l=Ye(e,n))&&r.unshift(Dr(e,l,a)),null!=(l=Ye(e,t))&&r.push(Dr(e,l,a))),e=e.return}return r}function zr(e){if(null===e)return null;do{e=e.return}while(e&&5!==e.tag);return e||null}function Ar(e,t,n,r,a){for(var l=t._reactName,o=[];null!==n&&n!==r;){var i=n,u=i.alternate,s=i.stateNode;if(null!==u&&u===r)break;5===i.tag&&null!==s&&(i=s,a?null!=(u=Ye(n,l))&&o.unshift(Dr(n,u,i)):a||null!=(u=Ye(n,l))&&o.push(Dr(n,u,i))),n=n.return}0!==o.length&&e.push({event:t,listeners:o})}function _r(){}var Pr=null,Ur=null;function Yr(e,t){switch(e){case"button":case"input":case"select":case"textarea":return!!t.autoFocus}return!1}function Qr(e,t){return"textarea"===e||"option"===e||"noscript"===e||"string"==typeof t.children||"number"==typeof t.children||"object"==typeof t.dangerouslySetInnerHTML&&null!==t.dangerouslySetInnerHTML&&null!=t.dangerouslySetInnerHTML.__html}var Rr="function"==typeof setTimeout?setTimeout:void 0,Fr="function"==typeof clearTimeout?clearTimeout:void 0;function Vr(e){(1===e.nodeType||9===e.nodeType&&null!=(e=e.body))&&(e.textContent="")}function Br(e){for(;null!=e;e=e.nextSibling){var t=e.nodeType;if(1===t||3===t)break}return e}function Wr(e){e=e.previousSibling;for(var t=0;e;){if(8===e.nodeType){var n=e.data;if("$"===n||"$!"===n||"$?"===n){if(0===t)return e;t--}else"/$"===n&&t++}e=e.previousSibling}return null}var Hr=0,Kr=Math.random().toString(36).slice(2),Gr="__reactFiber$"+Kr,$r="__reactProps$"+Kr,qr="__reactContainer$"+Kr,Zr="__reactEvents$"+Kr;function Xr(e){var t=e[Gr];if(t)return t;for(var n=e.parentNode;n;){if(t=n[qr]||n[Gr]){if(n=t.alternate,null!==t.child||null!==n&&null!==n.child)for(e=Wr(e);null!==e;){if(n=e[Gr])return n;e=Wr(e)}return t}n=(e=n).parentNode}return null}function Jr(e){return!(e=e[Gr]||e[qr])||5!==e.tag&&6!==e.tag&&13!==e.tag&&3!==e.tag?null:e}function ea(e){if(5===e.tag||6===e.tag)return e.stateNode;throw Error(o(33))}function ta(e){return e[$r]||null}function na(e){var t=e[Zr];return void 0===t&&(t=e[Zr]=new Set),t}var ra=[],aa=-1;function la(e){return{current:e}}function oa(e){0>aa||(e.current=ra[aa],ra[aa]=null,aa--)}function ia(e,t){aa++,ra[aa]=e.current,e.current=t}var ua={},sa=la(ua),ca=la(!1),fa=ua;function da(e,t){var n=e.type.contextTypes;if(!n)return ua;var r=e.stateNode;if(r&&r.__reactInternalMemoizedUnmaskedChildContext===t)return r.__reactInternalMemoizedMaskedChildContext;var a,l={};for(a in n)l[a]=t[a];return r&&((e=e.stateNode).__reactInternalMemoizedUnmaskedChildContext=t,e.__reactInternalMemoizedMaskedChildContext=l),l}function pa(e){return null!=e.childContextTypes}function ya(){oa(ca),oa(sa)}function ha(e,t,n){if(sa.current!==ua)throw Error(o(168));ia(sa,t),ia(ca,n)}function ga(e,t,n){var r=e.stateNode;if(e=t.childContextTypes,"function"!=typeof r.getChildContext)return n;for(var l in r=r.getChildContext())if(!(l in e))throw Error(o(108,K(t)||"Unknown",l));return a({},n,r)}function ma(e){return e=(e=e.stateNode)&&e.__reactInternalMemoizedMergedChildContext||ua,fa=sa.current,ia(sa,e),ia(ca,ca.current),!0}function va(e,t,n){var r=e.stateNode;if(!r)throw Error(o(169));n?(e=ga(e,t,fa),r.__reactInternalMemoizedMergedChildContext=e,oa(ca),oa(sa),ia(sa,e)):oa(ca),ia(ca,n)}var ba=null,Ma=null,Ea=l.unstable_runWithPriority,La=l.unstable_scheduleCallback,Na=l.unstable_cancelCallback,wa=l.unstable_shouldYield,Sa=l.unstable_requestPaint,xa=l.unstable_now,ka=l.unstable_getCurrentPriorityLevel,ja=l.unstable_ImmediatePriority,Ta=l.unstable_UserBlockingPriority,Ca=l.unstable_NormalPriority,Ia=l.unstable_LowPriority,Da=l.unstable_IdlePriority,Oa={},za=void 0!==Sa?Sa:function(){},Aa=null,_a=null,Pa=!1,Ua=xa(),Ya=1e4>Ua?xa:function(){return xa()-Ua};function Qa(){switch(ka()){case ja:return 99;case Ta:return 98;case Ca:return 97;case Ia:return 96;case Da:return 95;default:throw Error(o(332))}}function Ra(e){switch(e){case 99:return ja;case 98:return Ta;case 97:return Ca;case 96:return Ia;case 95:return Da;default:throw Error(o(332))}}function Fa(e,t){return e=Ra(e),Ea(e,t)}function Va(e,t,n){return e=Ra(e),La(e,t,n)}function Ba(){if(null!==_a){var e=_a;_a=null,Na(e)}Wa()}function Wa(){if(!Pa&&null!==Aa){Pa=!0;var e=0;try{var t=Aa;Fa(99,(function(){for(;e<t.length;e++){var n=t[e];do{n=n(!0)}while(null!==n)}})),Aa=null}catch(t){throw null!==Aa&&(Aa=Aa.slice(e+1)),La(ja,Ba),t}finally{Pa=!1}}}var Ha=E.ReactCurrentBatchConfig;function Ka(e,t){if(e&&e.defaultProps){for(var n in t=a({},t),e=e.defaultProps)void 0===t[n]&&(t[n]=e[n]);return t}return t}var Ga=la(null),$a=null,qa=null,Za=null;function Xa(){Za=qa=$a=null}function Ja(e){var t=Ga.current;oa(Ga),e.type._context._currentValue=t}function el(e,t){for(;null!==e;){var n=e.alternate;if((e.childLanes&t)===t){if(null===n||(n.childLanes&t)===t)break;n.childLanes|=t}else e.childLanes|=t,null!==n&&(n.childLanes|=t);e=e.return}}function tl(e,t){$a=e,Za=qa=null,null!==(e=e.dependencies)&&null!==e.firstContext&&(0!=(e.lanes&t)&&(Oo=!0),e.firstContext=null)}function nl(e,t){if(Za!==e&&!1!==t&&0!==t)if("number"==typeof t&&1073741823!==t||(Za=e,t=1073741823),t={context:e,observedBits:t,next:null},null===qa){if(null===$a)throw Error(o(308));qa=t,$a.dependencies={lanes:0,firstContext:t,responders:null}}else qa=qa.next=t;return e._currentValue}var rl=!1;function al(e){e.updateQueue={baseState:e.memoizedState,firstBaseUpdate:null,lastBaseUpdate:null,shared:{pending:null},effects:null}}function ll(e,t){e=e.updateQueue,t.updateQueue===e&&(t.updateQueue={baseState:e.baseState,firstBaseUpdate:e.firstBaseUpdate,lastBaseUpdate:e.lastBaseUpdate,shared:e.shared,effects:e.effects})}function ol(e,t){return{eventTime:e,lane:t,tag:0,payload:null,callback:null,next:null}}function il(e,t){if(null!==(e=e.updateQueue)){var n=(e=e.shared).pending;null===n?t.next=t:(t.next=n.next,n.next=t),e.pending=t}}function ul(e,t){var n=e.updateQueue,r=e.alternate;if(null!==r&&n===(r=r.updateQueue)){var a=null,l=null;if(null!==(n=n.firstBaseUpdate)){do{var o={eventTime:n.eventTime,lane:n.lane,tag:n.tag,payload:n.payload,callback:n.callback,next:null};null===l?a=l=o:l=l.next=o,n=n.next}while(null!==n);null===l?a=l=t:l=l.next=t}else a=l=t;return n={baseState:r.baseState,firstBaseUpdate:a,lastBaseUpdate:l,shared:r.shared,effects:r.effects},void(e.updateQueue=n)}null===(e=n.lastBaseUpdate)?n.firstBaseUpdate=t:e.next=t,n.lastBaseUpdate=t}function sl(e,t,n,r){var l=e.updateQueue;rl=!1;var o=l.firstBaseUpdate,i=l.lastBaseUpdate,u=l.shared.pending;if(null!==u){l.shared.pending=null;var s=u,c=s.next;s.next=null,null===i?o=c:i.next=c,i=s;var f=e.alternate;if(null!==f){var d=(f=f.updateQueue).lastBaseUpdate;d!==i&&(null===d?f.firstBaseUpdate=c:d.next=c,f.lastBaseUpdate=s)}}if(null!==o){for(d=l.baseState,i=0,f=c=s=null;;){u=o.lane;var p=o.eventTime;if((r&u)===u){null!==f&&(f=f.next={eventTime:p,lane:0,tag:o.tag,payload:o.payload,callback:o.callback,next:null});e:{var y=e,h=o;switch(u=t,p=n,h.tag){case 1:if("function"==typeof(y=h.payload)){d=y.call(p,d,u);break e}d=y;break e;case 3:y.flags=-4097&y.flags|64;case 0:if(null==(u="function"==typeof(y=h.payload)?y.call(p,d,u):y))break e;d=a({},d,u);break e;case 2:rl=!0}}null!==o.callback&&(e.flags|=32,null===(u=l.effects)?l.effects=[o]:u.push(o))}else p={eventTime:p,lane:u,tag:o.tag,payload:o.payload,callback:o.callback,next:null},null===f?(c=f=p,s=d):f=f.next=p,i|=u;if(null===(o=o.next)){if(null===(u=l.shared.pending))break;o=u.next,u.next=null,l.lastBaseUpdate=u,l.shared.pending=null}}null===f&&(s=d),l.baseState=s,l.firstBaseUpdate=c,l.lastBaseUpdate=f,Ai|=i,e.lanes=i,e.memoizedState=d}}function cl(e,t,n){if(e=t.effects,t.effects=null,null!==e)for(t=0;t<e.length;t++){var r=e[t],a=r.callback;if(null!==a){if(r.callback=null,r=n,"function"!=typeof a)throw Error(o(191,a));a.call(r)}}}var fl=(new r.Component).refs;function dl(e,t,n,r){n=null==(n=n(r,t=e.memoizedState))?t:a({},t,n),e.memoizedState=n,0===e.lanes&&(e.updateQueue.baseState=n)}var pl={isMounted:function(e){return!!(e=e._reactInternals)&&$e(e)===e},enqueueSetState:function(e,t,n){e=e._reactInternals;var r=ou(),a=iu(e),l=ol(r,a);l.payload=t,null!=n&&(l.callback=n),il(e,l),uu(e,a,r)},enqueueReplaceState:function(e,t,n){e=e._reactInternals;var r=ou(),a=iu(e),l=ol(r,a);l.tag=1,l.payload=t,null!=n&&(l.callback=n),il(e,l),uu(e,a,r)},enqueueForceUpdate:function(e,t){e=e._reactInternals;var n=ou(),r=iu(e),a=ol(n,r);a.tag=2,null!=t&&(a.callback=t),il(e,a),uu(e,r,n)}};function yl(e,t,n,r,a,l,o){return"function"==typeof(e=e.stateNode).shouldComponentUpdate?e.shouldComponentUpdate(r,l,o):!(t.prototype&&t.prototype.isPureReactComponent&&ur(n,r)&&ur(a,l))}function hl(e,t,n){var r=!1,a=ua,l=t.contextType;return"object"==typeof l&&null!==l?l=nl(l):(a=pa(t)?fa:sa.current,l=(r=null!=(r=t.contextTypes))?da(e,a):ua),t=new t(n,l),e.memoizedState=null!==t.state&&void 0!==t.state?t.state:null,t.updater=pl,e.stateNode=t,t._reactInternals=e,r&&((e=e.stateNode).__reactInternalMemoizedUnmaskedChildContext=a,e.__reactInternalMemoizedMaskedChildContext=l),t}function gl(e,t,n,r){e=t.state,"function"==typeof t.componentWillReceiveProps&&t.componentWillReceiveProps(n,r),"function"==typeof t.UNSAFE_componentWillReceiveProps&&t.UNSAFE_componentWillReceiveProps(n,r),t.state!==e&&pl.enqueueReplaceState(t,t.state,null)}function ml(e,t,n,r){var a=e.stateNode;a.props=n,a.state=e.memoizedState,a.refs=fl,al(e);var l=t.contextType;"object"==typeof l&&null!==l?a.context=nl(l):(l=pa(t)?fa:sa.current,a.context=da(e,l)),sl(e,n,a,r),a.state=e.memoizedState,"function"==typeof(l=t.getDerivedStateFromProps)&&(dl(e,t,l,n),a.state=e.memoizedState),"function"==typeof t.getDerivedStateFromProps||"function"==typeof a.getSnapshotBeforeUpdate||"function"!=typeof a.UNSAFE_componentWillMount&&"function"!=typeof a.componentWillMount||(t=a.state,"function"==typeof a.componentWillMount&&a.componentWillMount(),"function"==typeof a.UNSAFE_componentWillMount&&a.UNSAFE_componentWillMount(),t!==a.state&&pl.enqueueReplaceState(a,a.state,null),sl(e,n,a,r),a.state=e.memoizedState),"function"==typeof a.componentDidMount&&(e.flags|=4)}var vl=Array.isArray;function bl(e,t,n){if(null!==(e=n.ref)&&"function"!=typeof e&&"object"!=typeof e){if(n._owner){if(n=n._owner){if(1!==n.tag)throw Error(o(309));var r=n.stateNode}if(!r)throw Error(o(147,e));var a=""+e;return null!==t&&null!==t.ref&&"function"==typeof t.ref&&t.ref._stringRef===a?t.ref:((t=function(e){var t=r.refs;t===fl&&(t=r.refs={}),null===e?delete t[a]:t[a]=e})._stringRef=a,t)}if("string"!=typeof e)throw Error(o(284));if(!n._owner)throw Error(o(290,e))}return e}function Ml(e,t){if("textarea"!==e.type)throw Error(o(31,"[object Object]"===Object.prototype.toString.call(t)?"object with keys {"+Object.keys(t).join(", ")+"}":t))}function El(e){function t(t,n){if(e){var r=t.lastEffect;null!==r?(r.nextEffect=n,t.lastEffect=n):t.firstEffect=t.lastEffect=n,n.nextEffect=null,n.flags=8}}function n(n,r){if(!e)return null;for(;null!==r;)t(n,r),r=r.sibling;return null}function r(e,t){for(e=new Map;null!==t;)null!==t.key?e.set(t.key,t):e.set(t.index,t),t=t.sibling;return e}function a(e,t){return(e=Qu(e,t)).index=0,e.sibling=null,e}function l(t,n,r){return t.index=r,e?null!==(r=t.alternate)?(r=r.index)<n?(t.flags=2,n):r:(t.flags=2,n):n}function i(t){return e&&null===t.alternate&&(t.flags=2),t}function u(e,t,n,r){return null===t||6!==t.tag?((t=Bu(n,e.mode,r)).return=e,t):((t=a(t,n)).return=e,t)}function s(e,t,n,r){return null!==t&&t.elementType===n.type?((r=a(t,n.props)).ref=bl(e,t,n),r.return=e,r):((r=Ru(n.type,n.key,n.props,null,e.mode,r)).ref=bl(e,t,n),r.return=e,r)}function c(e,t,n,r){return null===t||4!==t.tag||t.stateNode.containerInfo!==n.containerInfo||t.stateNode.implementation!==n.implementation?((t=Wu(n,e.mode,r)).return=e,t):((t=a(t,n.children||[])).return=e,t)}function f(e,t,n,r,l){return null===t||7!==t.tag?((t=Fu(n,e.mode,r,l)).return=e,t):((t=a(t,n)).return=e,t)}function d(e,t,n){if("string"==typeof t||"number"==typeof t)return(t=Bu(""+t,e.mode,n)).return=e,t;if("object"==typeof t&&null!==t){switch(t.$$typeof){case L:return(n=Ru(t.type,t.key,t.props,null,e.mode,n)).ref=bl(e,null,t),n.return=e,n;case N:return(t=Wu(t,e.mode,n)).return=e,t}if(vl(t)||F(t))return(t=Fu(t,e.mode,n,null)).return=e,t;Ml(e,t)}return null}function p(e,t,n,r){var a=null!==t?t.key:null;if("string"==typeof n||"number"==typeof n)return null!==a?null:u(e,t,""+n,r);if("object"==typeof n&&null!==n){switch(n.$$typeof){case L:return n.key===a?n.type===w?f(e,t,n.props.children,r,a):s(e,t,n,r):null;case N:return n.key===a?c(e,t,n,r):null}if(vl(n)||F(n))return null!==a?null:f(e,t,n,r,null);Ml(e,n)}return null}function y(e,t,n,r,a){if("string"==typeof r||"number"==typeof r)return u(t,e=e.get(n)||null,""+r,a);if("object"==typeof r&&null!==r){switch(r.$$typeof){case L:return e=e.get(null===r.key?n:r.key)||null,r.type===w?f(t,e,r.props.children,a,r.key):s(t,e,r,a);case N:return c(t,e=e.get(null===r.key?n:r.key)||null,r,a)}if(vl(r)||F(r))return f(t,e=e.get(n)||null,r,a,null);Ml(t,r)}return null}function h(a,o,i,u){for(var s=null,c=null,f=o,h=o=0,g=null;null!==f&&h<i.length;h++){f.index>h?(g=f,f=null):g=f.sibling;var m=p(a,f,i[h],u);if(null===m){null===f&&(f=g);break}e&&f&&null===m.alternate&&t(a,f),o=l(m,o,h),null===c?s=m:c.sibling=m,c=m,f=g}if(h===i.length)return n(a,f),s;if(null===f){for(;h<i.length;h++)null!==(f=d(a,i[h],u))&&(o=l(f,o,h),null===c?s=f:c.sibling=f,c=f);return s}for(f=r(a,f);h<i.length;h++)null!==(g=y(f,a,h,i[h],u))&&(e&&null!==g.alternate&&f.delete(null===g.key?h:g.key),o=l(g,o,h),null===c?s=g:c.sibling=g,c=g);return e&&f.forEach((function(e){return t(a,e)})),s}function g(a,i,u,s){var c=F(u);if("function"!=typeof c)throw Error(o(150));if(null==(u=c.call(u)))throw Error(o(151));for(var f=c=null,h=i,g=i=0,m=null,v=u.next();null!==h&&!v.done;g++,v=u.next()){h.index>g?(m=h,h=null):m=h.sibling;var b=p(a,h,v.value,s);if(null===b){null===h&&(h=m);break}e&&h&&null===b.alternate&&t(a,h),i=l(b,i,g),null===f?c=b:f.sibling=b,f=b,h=m}if(v.done)return n(a,h),c;if(null===h){for(;!v.done;g++,v=u.next())null!==(v=d(a,v.value,s))&&(i=l(v,i,g),null===f?c=v:f.sibling=v,f=v);return c}for(h=r(a,h);!v.done;g++,v=u.next())null!==(v=y(h,a,g,v.value,s))&&(e&&null!==v.alternate&&h.delete(null===v.key?g:v.key),i=l(v,i,g),null===f?c=v:f.sibling=v,f=v);return e&&h.forEach((function(e){return t(a,e)})),c}return function(e,r,l,u){var s="object"==typeof l&&null!==l&&l.type===w&&null===l.key;s&&(l=l.props.children);var c="object"==typeof l&&null!==l;if(c)switch(l.$$typeof){case L:e:{for(c=l.key,s=r;null!==s;){if(s.key===c){switch(s.tag){case 7:if(l.type===w){n(e,s.sibling),(r=a(s,l.props.children)).return=e,e=r;break e}break;default:if(s.elementType===l.type){n(e,s.sibling),(r=a(s,l.props)).ref=bl(e,s,l),r.return=e,e=r;break e}}n(e,s);break}t(e,s),s=s.sibling}l.type===w?((r=Fu(l.props.children,e.mode,u,l.key)).return=e,e=r):((u=Ru(l.type,l.key,l.props,null,e.mode,u)).ref=bl(e,r,l),u.return=e,e=u)}return i(e);case N:e:{for(s=l.key;null!==r;){if(r.key===s){if(4===r.tag&&r.stateNode.containerInfo===l.containerInfo&&r.stateNode.implementation===l.implementation){n(e,r.sibling),(r=a(r,l.children||[])).return=e,e=r;break e}n(e,r);break}t(e,r),r=r.sibling}(r=Wu(l,e.mode,u)).return=e,e=r}return i(e)}if("string"==typeof l||"number"==typeof l)return l=""+l,null!==r&&6===r.tag?(n(e,r.sibling),(r=a(r,l)).return=e,e=r):(n(e,r),(r=Bu(l,e.mode,u)).return=e,e=r),i(e);if(vl(l))return h(e,r,l,u);if(F(l))return g(e,r,l,u);if(c&&Ml(e,l),void 0===l&&!s)switch(e.tag){case 1:case 22:case 0:case 11:case 15:throw Error(o(152,K(e.type)||"Component"))}return n(e,r)}}var Ll=El(!0),Nl=El(!1),wl={},Sl=la(wl),xl=la(wl),kl=la(wl);function jl(e){if(e===wl)throw Error(o(174));return e}function Tl(e,t){switch(ia(kl,t),ia(xl,e),ia(Sl,wl),e=t.nodeType){case 9:case 11:t=(t=t.documentElement)?t.namespaceURI:pe(null,"");break;default:t=pe(t=(e=8===e?t.parentNode:t).namespaceURI||null,e=e.tagName)}oa(Sl),ia(Sl,t)}function Cl(){oa(Sl),oa(xl),oa(kl)}function Il(e){jl(kl.current);var t=jl(Sl.current),n=pe(t,e.type);t!==n&&(ia(xl,e),ia(Sl,n))}function Dl(e){xl.current===e&&(oa(Sl),oa(xl))}var Ol=la(0);function zl(e){for(var t=e;null!==t;){if(13===t.tag){var n=t.memoizedState;if(null!==n&&(null===(n=n.dehydrated)||"$?"===n.data||"$!"===n.data))return t}else if(19===t.tag&&void 0!==t.memoizedProps.revealOrder){if(0!=(64&t.flags))return t}else if(null!==t.child){t.child.return=t,t=t.child;continue}if(t===e)break;for(;null===t.sibling;){if(null===t.return||t.return===e)return null;t=t.return}t.sibling.return=t.return,t=t.sibling}return null}var Al=null,_l=null,Pl=!1;function Ul(e,t){var n=Uu(5,null,null,0);n.elementType="DELETED",n.type="DELETED",n.stateNode=t,n.return=e,n.flags=8,null!==e.lastEffect?(e.lastEffect.nextEffect=n,e.lastEffect=n):e.firstEffect=e.lastEffect=n}function Yl(e,t){switch(e.tag){case 5:var n=e.type;return null!==(t=1!==t.nodeType||n.toLowerCase()!==t.nodeName.toLowerCase()?null:t)&&(e.stateNode=t,!0);case 6:return null!==(t=""===e.pendingProps||3!==t.nodeType?null:t)&&(e.stateNode=t,!0);case 13:default:return!1}}function Ql(e){if(Pl){var t=_l;if(t){var n=t;if(!Yl(e,t)){if(!(t=Br(n.nextSibling))||!Yl(e,t))return e.flags=-1025&e.flags|2,Pl=!1,void(Al=e);Ul(Al,n)}Al=e,_l=Br(t.firstChild)}else e.flags=-1025&e.flags|2,Pl=!1,Al=e}}function Rl(e){for(e=e.return;null!==e&&5!==e.tag&&3!==e.tag&&13!==e.tag;)e=e.return;Al=e}function Fl(e){if(e!==Al)return!1;if(!Pl)return Rl(e),Pl=!0,!1;var t=e.type;if(5!==e.tag||"head"!==t&&"body"!==t&&!Qr(t,e.memoizedProps))for(t=_l;t;)Ul(e,t),t=Br(t.nextSibling);if(Rl(e),13===e.tag){if(!(e=null!==(e=e.memoizedState)?e.dehydrated:null))throw Error(o(317));e:{for(e=e.nextSibling,t=0;e;){if(8===e.nodeType){var n=e.data;if("/$"===n){if(0===t){_l=Br(e.nextSibling);break e}t--}else"$"!==n&&"$!"!==n&&"$?"!==n||t++}e=e.nextSibling}_l=null}}else _l=Al?Br(e.stateNode.nextSibling):null;return!0}function Vl(){_l=Al=null,Pl=!1}var Bl=[];function Wl(){for(var e=0;e<Bl.length;e++)Bl[e]._workInProgressVersionPrimary=null;Bl.length=0}var Hl=E.ReactCurrentDispatcher,Kl=E.ReactCurrentBatchConfig,Gl=0,$l=null,ql=null,Zl=null,Xl=!1,Jl=!1;function eo(){throw Error(o(321))}function to(e,t){if(null===t)return!1;for(var n=0;n<t.length&&n<e.length;n++)if(!or(e[n],t[n]))return!1;return!0}function no(e,t,n,r,a,l){if(Gl=l,$l=t,t.memoizedState=null,t.updateQueue=null,t.lanes=0,Hl.current=null===e||null===e.memoizedState?To:Co,e=n(r,a),Jl){l=0;do{if(Jl=!1,!(25>l))throw Error(o(301));l+=1,Zl=ql=null,t.updateQueue=null,Hl.current=Io,e=n(r,a)}while(Jl)}if(Hl.current=jo,t=null!==ql&&null!==ql.next,Gl=0,Zl=ql=$l=null,Xl=!1,t)throw Error(o(300));return e}function ro(){var e={memoizedState:null,baseState:null,baseQueue:null,queue:null,next:null};return null===Zl?$l.memoizedState=Zl=e:Zl=Zl.next=e,Zl}function ao(){if(null===ql){var e=$l.alternate;e=null!==e?e.memoizedState:null}else e=ql.next;var t=null===Zl?$l.memoizedState:Zl.next;if(null!==t)Zl=t,ql=e;else{if(null===e)throw Error(o(310));e={memoizedState:(ql=e).memoizedState,baseState:ql.baseState,baseQueue:ql.baseQueue,queue:ql.queue,next:null},null===Zl?$l.memoizedState=Zl=e:Zl=Zl.next=e}return Zl}function lo(e,t){return"function"==typeof t?t(e):t}function oo(e){var t=ao(),n=t.queue;if(null===n)throw Error(o(311));n.lastRenderedReducer=e;var r=ql,a=r.baseQueue,l=n.pending;if(null!==l){if(null!==a){var i=a.next;a.next=l.next,l.next=i}r.baseQueue=a=l,n.pending=null}if(null!==a){a=a.next,r=r.baseState;var u=i=l=null,s=a;do{var c=s.lane;if((Gl&c)===c)null!==u&&(u=u.next={lane:0,action:s.action,eagerReducer:s.eagerReducer,eagerState:s.eagerState,next:null}),r=s.eagerReducer===e?s.eagerState:e(r,s.action);else{var f={lane:c,action:s.action,eagerReducer:s.eagerReducer,eagerState:s.eagerState,next:null};null===u?(i=u=f,l=r):u=u.next=f,$l.lanes|=c,Ai|=c}s=s.next}while(null!==s&&s!==a);null===u?l=r:u.next=i,or(r,t.memoizedState)||(Oo=!0),t.memoizedState=r,t.baseState=l,t.baseQueue=u,n.lastRenderedState=r}return[t.memoizedState,n.dispatch]}function io(e){var t=ao(),n=t.queue;if(null===n)throw Error(o(311));n.lastRenderedReducer=e;var r=n.dispatch,a=n.pending,l=t.memoizedState;if(null!==a){n.pending=null;var i=a=a.next;do{l=e(l,i.action),i=i.next}while(i!==a);or(l,t.memoizedState)||(Oo=!0),t.memoizedState=l,null===t.baseQueue&&(t.baseState=l),n.lastRenderedState=l}return[l,r]}function uo(e,t,n){var r=t._getVersion;r=r(t._source);var a=t._workInProgressVersionPrimary;if(null!==a?e=a===r:(e=e.mutableReadLanes,(e=(Gl&e)===e)&&(t._workInProgressVersionPrimary=r,Bl.push(t))),e)return n(t._source);throw Bl.push(t),Error(o(350))}function so(e,t,n,r){var a=ki;if(null===a)throw Error(o(349));var l=t._getVersion,i=l(t._source),u=Hl.current,s=u.useState((function(){return uo(a,t,n)})),c=s[1],f=s[0];s=Zl;var d=e.memoizedState,p=d.refs,y=p.getSnapshot,h=d.source;d=d.subscribe;var g=$l;return e.memoizedState={refs:p,source:t,subscribe:r},u.useEffect((function(){p.getSnapshot=n,p.setSnapshot=c;var e=l(t._source);if(!or(i,e)){e=n(t._source),or(f,e)||(c(e),e=iu(g),a.mutableReadLanes|=e&a.pendingLanes),e=a.mutableReadLanes,a.entangledLanes|=e;for(var r=a.entanglements,o=e;0<o;){var u=31-Vt(o),s=1<<u;r[u]|=e,o&=~s}}}),[n,t,r]),u.useEffect((function(){return r(t._source,(function(){var e=p.getSnapshot,n=p.setSnapshot;try{n(e(t._source));var r=iu(g);a.mutableReadLanes|=r&a.pendingLanes}catch(e){n((function(){throw e}))}}))}),[t,r]),or(y,n)&&or(h,t)&&or(d,r)||((e={pending:null,dispatch:null,lastRenderedReducer:lo,lastRenderedState:f}).dispatch=c=ko.bind(null,$l,e),s.queue=e,s.baseQueue=null,f=uo(a,t,n),s.memoizedState=s.baseState=f),f}function co(e,t,n){return so(ao(),e,t,n)}function fo(e){var t=ro();return"function"==typeof e&&(e=e()),t.memoizedState=t.baseState=e,e=(e=t.queue={pending:null,dispatch:null,lastRenderedReducer:lo,lastRenderedState:e}).dispatch=ko.bind(null,$l,e),[t.memoizedState,e]}function po(e,t,n,r){return e={tag:e,create:t,destroy:n,deps:r,next:null},null===(t=$l.updateQueue)?(t={lastEffect:null},$l.updateQueue=t,t.lastEffect=e.next=e):null===(n=t.lastEffect)?t.lastEffect=e.next=e:(r=n.next,n.next=e,e.next=r,t.lastEffect=e),e}function yo(e){return e={current:e},ro().memoizedState=e}function ho(){return ao().memoizedState}function go(e,t,n,r){var a=ro();$l.flags|=e,a.memoizedState=po(1|t,n,void 0,void 0===r?null:r)}function mo(e,t,n,r){var a=ao();r=void 0===r?null:r;var l=void 0;if(null!==ql){var o=ql.memoizedState;if(l=o.destroy,null!==r&&to(r,o.deps))return void po(t,n,l,r)}$l.flags|=e,a.memoizedState=po(1|t,n,l,r)}function vo(e,t){return go(516,4,e,t)}function bo(e,t){return mo(516,4,e,t)}function Mo(e,t){return mo(4,2,e,t)}function Eo(e,t){return"function"==typeof t?(e=e(),t(e),function(){t(null)}):null!=t?(e=e(),t.current=e,function(){t.current=null}):void 0}function Lo(e,t,n){return n=null!=n?n.concat([e]):null,mo(4,2,Eo.bind(null,t,e),n)}function No(){}function wo(e,t){var n=ao();t=void 0===t?null:t;var r=n.memoizedState;return null!==r&&null!==t&&to(t,r[1])?r[0]:(n.memoizedState=[e,t],e)}function So(e,t){var n=ao();t=void 0===t?null:t;var r=n.memoizedState;return null!==r&&null!==t&&to(t,r[1])?r[0]:(e=e(),n.memoizedState=[e,t],e)}function xo(e,t){var n=Qa();Fa(98>n?98:n,(function(){e(!0)})),Fa(97<n?97:n,(function(){var n=Kl.transition;Kl.transition=1;try{e(!1),t()}finally{Kl.transition=n}}))}function ko(e,t,n){var r=ou(),a=iu(e),l={lane:a,action:n,eagerReducer:null,eagerState:null,next:null},o=t.pending;if(null===o?l.next=l:(l.next=o.next,o.next=l),t.pending=l,o=e.alternate,e===$l||null!==o&&o===$l)Jl=Xl=!0;else{if(0===e.lanes&&(null===o||0===o.lanes)&&null!==(o=t.lastRenderedReducer))try{var i=t.lastRenderedState,u=o(i,n);if(l.eagerReducer=o,l.eagerState=u,or(u,i))return}catch(e){}uu(e,a,r)}}var jo={readContext:nl,useCallback:eo,useContext:eo,useEffect:eo,useImperativeHandle:eo,useLayoutEffect:eo,useMemo:eo,useReducer:eo,useRef:eo,useState:eo,useDebugValue:eo,useDeferredValue:eo,useTransition:eo,useMutableSource:eo,useOpaqueIdentifier:eo,unstable_isNewReconciler:!1},To={readContext:nl,useCallback:function(e,t){return ro().memoizedState=[e,void 0===t?null:t],e},useContext:nl,useEffect:vo,useImperativeHandle:function(e,t,n){return n=null!=n?n.concat([e]):null,go(4,2,Eo.bind(null,t,e),n)},useLayoutEffect:function(e,t){return go(4,2,e,t)},useMemo:function(e,t){var n=ro();return t=void 0===t?null:t,e=e(),n.memoizedState=[e,t],e},useReducer:function(e,t,n){var r=ro();return t=void 0!==n?n(t):t,r.memoizedState=r.baseState=t,e=(e=r.queue={pending:null,dispatch:null,lastRenderedReducer:e,lastRenderedState:t}).dispatch=ko.bind(null,$l,e),[r.memoizedState,e]},useRef:yo,useState:fo,useDebugValue:No,useDeferredValue:function(e){var t=fo(e),n=t[0],r=t[1];return vo((function(){var t=Kl.transition;Kl.transition=1;try{r(e)}finally{Kl.transition=t}}),[e]),n},useTransition:function(){var e=fo(!1),t=e[0];return yo(e=xo.bind(null,e[1])),[e,t]},useMutableSource:function(e,t,n){var r=ro();return r.memoizedState={refs:{getSnapshot:t,setSnapshot:null},source:e,subscribe:n},so(r,e,t,n)},useOpaqueIdentifier:function(){if(Pl){var e=!1,t=function(e){return{$$typeof:A,toString:e,valueOf:e}}((function(){throw e||(e=!0,n("r:"+(Hr++).toString(36))),Error(o(355))})),n=fo(t)[1];return 0==(2&$l.mode)&&($l.flags|=516,po(5,(function(){n("r:"+(Hr++).toString(36))}),void 0,null)),t}return fo(t="r:"+(Hr++).toString(36)),t},unstable_isNewReconciler:!1},Co={readContext:nl,useCallback:wo,useContext:nl,useEffect:bo,useImperativeHandle:Lo,useLayoutEffect:Mo,useMemo:So,useReducer:oo,useRef:ho,useState:function(){return oo(lo)},useDebugValue:No,useDeferredValue:function(e){var t=oo(lo),n=t[0],r=t[1];return bo((function(){var t=Kl.transition;Kl.transition=1;try{r(e)}finally{Kl.transition=t}}),[e]),n},useTransition:function(){var e=oo(lo)[0];return[ho().current,e]},useMutableSource:co,useOpaqueIdentifier:function(){return oo(lo)[0]},unstable_isNewReconciler:!1},Io={readContext:nl,useCallback:wo,useContext:nl,useEffect:bo,useImperativeHandle:Lo,useLayoutEffect:Mo,useMemo:So,useReducer:io,useRef:ho,useState:function(){return io(lo)},useDebugValue:No,useDeferredValue:function(e){var t=io(lo),n=t[0],r=t[1];return bo((function(){var t=Kl.transition;Kl.transition=1;try{r(e)}finally{Kl.transition=t}}),[e]),n},useTransition:function(){var e=io(lo)[0];return[ho().current,e]},useMutableSource:co,useOpaqueIdentifier:function(){return io(lo)[0]},unstable_isNewReconciler:!1},Do=E.ReactCurrentOwner,Oo=!1;function zo(e,t,n,r){t.child=null===e?Nl(t,null,n,r):Ll(t,e.child,n,r)}function Ao(e,t,n,r,a){n=n.render;var l=t.ref;return tl(t,a),r=no(e,t,n,r,l,a),null===e||Oo?(t.flags|=1,zo(e,t,r,a),t.child):(t.updateQueue=e.updateQueue,t.flags&=-517,e.lanes&=~a,Jo(e,t,a))}function _o(e,t,n,r,a,l){if(null===e){var o=n.type;return"function"!=typeof o||Yu(o)||void 0!==o.defaultProps||null!==n.compare||void 0!==n.defaultProps?((e=Ru(n.type,null,r,t,t.mode,l)).ref=t.ref,e.return=t,t.child=e):(t.tag=15,t.type=o,Po(e,t,o,r,a,l))}return o=e.child,0==(a&l)&&(a=o.memoizedProps,(n=null!==(n=n.compare)?n:ur)(a,r)&&e.ref===t.ref)?Jo(e,t,l):(t.flags|=1,(e=Qu(o,r)).ref=t.ref,e.return=t,t.child=e)}function Po(e,t,n,r,a,l){if(null!==e&&ur(e.memoizedProps,r)&&e.ref===t.ref){if(Oo=!1,0==(l&a))return t.lanes=e.lanes,Jo(e,t,l);0!=(16384&e.flags)&&(Oo=!0)}return Qo(e,t,n,r,l)}function Uo(e,t,n){var r=t.pendingProps,a=r.children,l=null!==e?e.memoizedState:null;if("hidden"===r.mode||"unstable-defer-without-hiding"===r.mode)if(0==(4&t.mode))t.memoizedState={baseLanes:0},gu(0,n);else{if(0==(1073741824&n))return e=null!==l?l.baseLanes|n:n,t.lanes=t.childLanes=1073741824,t.memoizedState={baseLanes:e},gu(0,e),null;t.memoizedState={baseLanes:0},gu(0,null!==l?l.baseLanes:n)}else null!==l?(r=l.baseLanes|n,t.memoizedState=null):r=n,gu(0,r);return zo(e,t,a,n),t.child}function Yo(e,t){var n=t.ref;(null===e&&null!==n||null!==e&&e.ref!==n)&&(t.flags|=128)}function Qo(e,t,n,r,a){var l=pa(n)?fa:sa.current;return l=da(t,l),tl(t,a),n=no(e,t,n,r,l,a),null===e||Oo?(t.flags|=1,zo(e,t,n,a),t.child):(t.updateQueue=e.updateQueue,t.flags&=-517,e.lanes&=~a,Jo(e,t,a))}function Ro(e,t,n,r,a){if(pa(n)){var l=!0;ma(t)}else l=!1;if(tl(t,a),null===t.stateNode)null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),hl(t,n,r),ml(t,n,r,a),r=!0;else if(null===e){var o=t.stateNode,i=t.memoizedProps;o.props=i;var u=o.context,s=n.contextType;s="object"==typeof s&&null!==s?nl(s):da(t,s=pa(n)?fa:sa.current);var c=n.getDerivedStateFromProps,f="function"==typeof c||"function"==typeof o.getSnapshotBeforeUpdate;f||"function"!=typeof o.UNSAFE_componentWillReceiveProps&&"function"!=typeof o.componentWillReceiveProps||(i!==r||u!==s)&&gl(t,o,r,s),rl=!1;var d=t.memoizedState;o.state=d,sl(t,r,o,a),u=t.memoizedState,i!==r||d!==u||ca.current||rl?("function"==typeof c&&(dl(t,n,c,r),u=t.memoizedState),(i=rl||yl(t,n,i,r,d,u,s))?(f||"function"!=typeof o.UNSAFE_componentWillMount&&"function"!=typeof o.componentWillMount||("function"==typeof o.componentWillMount&&o.componentWillMount(),"function"==typeof o.UNSAFE_componentWillMount&&o.UNSAFE_componentWillMount()),"function"==typeof o.componentDidMount&&(t.flags|=4)):("function"==typeof o.componentDidMount&&(t.flags|=4),t.memoizedProps=r,t.memoizedState=u),o.props=r,o.state=u,o.context=s,r=i):("function"==typeof o.componentDidMount&&(t.flags|=4),r=!1)}else{o=t.stateNode,ll(e,t),i=t.memoizedProps,s=t.type===t.elementType?i:Ka(t.type,i),o.props=s,f=t.pendingProps,d=o.context,u="object"==typeof(u=n.contextType)&&null!==u?nl(u):da(t,u=pa(n)?fa:sa.current);var p=n.getDerivedStateFromProps;(c="function"==typeof p||"function"==typeof o.getSnapshotBeforeUpdate)||"function"!=typeof o.UNSAFE_componentWillReceiveProps&&"function"!=typeof o.componentWillReceiveProps||(i!==f||d!==u)&&gl(t,o,r,u),rl=!1,d=t.memoizedState,o.state=d,sl(t,r,o,a);var y=t.memoizedState;i!==f||d!==y||ca.current||rl?("function"==typeof p&&(dl(t,n,p,r),y=t.memoizedState),(s=rl||yl(t,n,s,r,d,y,u))?(c||"function"!=typeof o.UNSAFE_componentWillUpdate&&"function"!=typeof o.componentWillUpdate||("function"==typeof o.componentWillUpdate&&o.componentWillUpdate(r,y,u),"function"==typeof o.UNSAFE_componentWillUpdate&&o.UNSAFE_componentWillUpdate(r,y,u)),"function"==typeof o.componentDidUpdate&&(t.flags|=4),"function"==typeof o.getSnapshotBeforeUpdate&&(t.flags|=256)):("function"!=typeof o.componentDidUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=4),"function"!=typeof o.getSnapshotBeforeUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=256),t.memoizedProps=r,t.memoizedState=y),o.props=r,o.state=y,o.context=u,r=s):("function"!=typeof o.componentDidUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=4),"function"!=typeof o.getSnapshotBeforeUpdate||i===e.memoizedProps&&d===e.memoizedState||(t.flags|=256),r=!1)}return Fo(e,t,n,r,l,a)}function Fo(e,t,n,r,a,l){Yo(e,t);var o=0!=(64&t.flags);if(!r&&!o)return a&&va(t,n,!1),Jo(e,t,l);r=t.stateNode,Do.current=t;var i=o&&"function"!=typeof n.getDerivedStateFromError?null:r.render();return t.flags|=1,null!==e&&o?(t.child=Ll(t,e.child,null,l),t.child=Ll(t,null,i,l)):zo(e,t,i,l),t.memoizedState=r.state,a&&va(t,n,!0),t.child}function Vo(e){var t=e.stateNode;t.pendingContext?ha(0,t.pendingContext,t.pendingContext!==t.context):t.context&&ha(0,t.context,!1),Tl(e,t.containerInfo)}var Bo,Wo,Ho,Ko={dehydrated:null,retryLane:0};function Go(e,t,n){var r,a=t.pendingProps,l=Ol.current,o=!1;return(r=0!=(64&t.flags))||(r=(null===e||null!==e.memoizedState)&&0!=(2&l)),r?(o=!0,t.flags&=-65):null!==e&&null===e.memoizedState||void 0===a.fallback||!0===a.unstable_avoidThisFallback||(l|=1),ia(Ol,1&l),null===e?(void 0!==a.fallback&&Ql(t),e=a.children,l=a.fallback,o?(e=$o(t,e,l,n),t.child.memoizedState={baseLanes:n},t.memoizedState=Ko,e):"number"==typeof a.unstable_expectedLoadTime?(e=$o(t,e,l,n),t.child.memoizedState={baseLanes:n},t.memoizedState=Ko,t.lanes=33554432,e):((n=Vu({mode:"visible",children:e},t.mode,n,null)).return=t,t.child=n)):(e.memoizedState,o?(a=function(e,t,n,r,a){var l=t.mode,o=e.child;e=o.sibling;var i={mode:"hidden",children:n};return 0==(2&l)&&t.child!==o?((n=t.child).childLanes=0,n.pendingProps=i,null!==(o=n.lastEffect)?(t.firstEffect=n.firstEffect,t.lastEffect=o,o.nextEffect=null):t.firstEffect=t.lastEffect=null):n=Qu(o,i),null!==e?r=Qu(e,r):(r=Fu(r,l,a,null)).flags|=2,r.return=t,n.return=t,n.sibling=r,t.child=n,r}(e,t,a.children,a.fallback,n),o=t.child,l=e.child.memoizedState,o.memoizedState=null===l?{baseLanes:n}:{baseLanes:l.baseLanes|n},o.childLanes=e.childLanes&~n,t.memoizedState=Ko,a):(n=function(e,t,n,r){var a=e.child;return e=a.sibling,n=Qu(a,{mode:"visible",children:n}),0==(2&t.mode)&&(n.lanes=r),n.return=t,n.sibling=null,null!==e&&(e.nextEffect=null,e.flags=8,t.firstEffect=t.lastEffect=e),t.child=n}(e,t,a.children,n),t.memoizedState=null,n))}function $o(e,t,n,r){var a=e.mode,l=e.child;return t={mode:"hidden",children:t},0==(2&a)&&null!==l?(l.childLanes=0,l.pendingProps=t):l=Vu(t,a,0,null),n=Fu(n,a,r,null),l.return=e,n.return=e,l.sibling=n,e.child=l,n}function qo(e,t){e.lanes|=t;var n=e.alternate;null!==n&&(n.lanes|=t),el(e.return,t)}function Zo(e,t,n,r,a,l){var o=e.memoizedState;null===o?e.memoizedState={isBackwards:t,rendering:null,renderingStartTime:0,last:r,tail:n,tailMode:a,lastEffect:l}:(o.isBackwards=t,o.rendering=null,o.renderingStartTime=0,o.last=r,o.tail=n,o.tailMode=a,o.lastEffect=l)}function Xo(e,t,n){var r=t.pendingProps,a=r.revealOrder,l=r.tail;if(zo(e,t,r.children,n),0!=(2&(r=Ol.current)))r=1&r|2,t.flags|=64;else{if(null!==e&&0!=(64&e.flags))e:for(e=t.child;null!==e;){if(13===e.tag)null!==e.memoizedState&&qo(e,n);else if(19===e.tag)qo(e,n);else if(null!==e.child){e.child.return=e,e=e.child;continue}if(e===t)break e;for(;null===e.sibling;){if(null===e.return||e.return===t)break e;e=e.return}e.sibling.return=e.return,e=e.sibling}r&=1}if(ia(Ol,r),0==(2&t.mode))t.memoizedState=null;else switch(a){case"forwards":for(n=t.child,a=null;null!==n;)null!==(e=n.alternate)&&null===zl(e)&&(a=n),n=n.sibling;null===(n=a)?(a=t.child,t.child=null):(a=n.sibling,n.sibling=null),Zo(t,!1,a,n,l,t.lastEffect);break;case"backwards":for(n=null,a=t.child,t.child=null;null!==a;){if(null!==(e=a.alternate)&&null===zl(e)){t.child=a;break}e=a.sibling,a.sibling=n,n=a,a=e}Zo(t,!0,n,null,l,t.lastEffect);break;case"together":Zo(t,!1,null,null,void 0,t.lastEffect);break;default:t.memoizedState=null}return t.child}function Jo(e,t,n){if(null!==e&&(t.dependencies=e.dependencies),Ai|=t.lanes,0!=(n&t.childLanes)){if(null!==e&&t.child!==e.child)throw Error(o(153));if(null!==t.child){for(n=Qu(e=t.child,e.pendingProps),t.child=n,n.return=t;null!==e.sibling;)e=e.sibling,(n=n.sibling=Qu(e,e.pendingProps)).return=t;n.sibling=null}return t.child}return null}function ei(e,t){if(!Pl)switch(e.tailMode){case"hidden":t=e.tail;for(var n=null;null!==t;)null!==t.alternate&&(n=t),t=t.sibling;null===n?e.tail=null:n.sibling=null;break;case"collapsed":n=e.tail;for(var r=null;null!==n;)null!==n.alternate&&(r=n),n=n.sibling;null===r?t||null===e.tail?e.tail=null:e.tail.sibling=null:r.sibling=null}}function ti(e,t,n){var r=t.pendingProps;switch(t.tag){case 2:case 16:case 15:case 0:case 11:case 7:case 8:case 12:case 9:case 14:return null;case 1:return pa(t.type)&&ya(),null;case 3:return Cl(),oa(ca),oa(sa),Wl(),(r=t.stateNode).pendingContext&&(r.context=r.pendingContext,r.pendingContext=null),null!==e&&null!==e.child||(Fl(t)?t.flags|=4:r.hydrate||(t.flags|=256)),null;case 5:Dl(t);var l=jl(kl.current);if(n=t.type,null!==e&&null!=t.stateNode)Wo(e,t,n,r),e.ref!==t.ref&&(t.flags|=128);else{if(!r){if(null===t.stateNode)throw Error(o(166));return null}if(e=jl(Sl.current),Fl(t)){r=t.stateNode,n=t.type;var i=t.memoizedProps;switch(r[Gr]=t,r[$r]=i,n){case"dialog":xr("cancel",r),xr("close",r);break;case"iframe":case"object":case"embed":xr("load",r);break;case"video":case"audio":for(e=0;e<Lr.length;e++)xr(Lr[e],r);break;case"source":xr("error",r);break;case"img":case"image":case"link":xr("error",r),xr("load",r);break;case"details":xr("toggle",r);break;case"input":ee(r,i),xr("invalid",r);break;case"select":r._wrapperState={wasMultiple:!!i.multiple},xr("invalid",r);break;case"textarea":ue(r,i),xr("invalid",r)}for(var s in Ne(n,i),e=null,i)i.hasOwnProperty(s)&&(l=i[s],"children"===s?"string"==typeof l?r.textContent!==l&&(e=["children",l]):"number"==typeof l&&r.textContent!==""+l&&(e=["children",""+l]):u.hasOwnProperty(s)&&null!=l&&"onScroll"===s&&xr("scroll",r));switch(n){case"input":q(r),re(r,i,!0);break;case"textarea":q(r),ce(r);break;case"select":case"option":break;default:"function"==typeof i.onClick&&(r.onclick=_r)}r=e,t.updateQueue=r,null!==r&&(t.flags|=4)}else{switch(s=9===l.nodeType?l:l.ownerDocument,e===fe&&(e=de(n)),e===fe?"script"===n?((e=s.createElement("div")).innerHTML="<script><\/script>",e=e.removeChild(e.firstChild)):"string"==typeof r.is?e=s.createElement(n,{is:r.is}):(e=s.createElement(n),"select"===n&&(s=e,r.multiple?s.multiple=!0:r.size&&(s.size=r.size))):e=s.createElementNS(e,n),e[Gr]=t,e[$r]=r,Bo(e,t),t.stateNode=e,s=we(n,r),n){case"dialog":xr("cancel",e),xr("close",e),l=r;break;case"iframe":case"object":case"embed":xr("load",e),l=r;break;case"video":case"audio":for(l=0;l<Lr.length;l++)xr(Lr[l],e);l=r;break;case"source":xr("error",e),l=r;break;case"img":case"image":case"link":xr("error",e),xr("load",e),l=r;break;case"details":xr("toggle",e),l=r;break;case"input":ee(e,r),l=J(e,r),xr("invalid",e);break;case"option":l=le(e,r);break;case"select":e._wrapperState={wasMultiple:!!r.multiple},l=a({},r,{value:void 0}),xr("invalid",e);break;case"textarea":ue(e,r),l=ie(e,r),xr("invalid",e);break;default:l=r}Ne(n,l);var c=l;for(i in c)if(c.hasOwnProperty(i)){var f=c[i];"style"===i?Ee(e,f):"dangerouslySetInnerHTML"===i?null!=(f=f?f.__html:void 0)&&ge(e,f):"children"===i?"string"==typeof f?("textarea"!==n||""!==f)&&me(e,f):"number"==typeof f&&me(e,""+f):"suppressContentEditableWarning"!==i&&"suppressHydrationWarning"!==i&&"autoFocus"!==i&&(u.hasOwnProperty(i)?null!=f&&"onScroll"===i&&xr("scroll",e):null!=f&&M(e,i,f,s))}switch(n){case"input":q(e),re(e,r,!1);break;case"textarea":q(e),ce(e);break;case"option":null!=r.value&&e.setAttribute("value",""+G(r.value));break;case"select":e.multiple=!!r.multiple,null!=(i=r.value)?oe(e,!!r.multiple,i,!1):null!=r.defaultValue&&oe(e,!!r.multiple,r.defaultValue,!0);break;default:"function"==typeof l.onClick&&(e.onclick=_r)}Yr(n,r)&&(t.flags|=4)}null!==t.ref&&(t.flags|=128)}return null;case 6:if(e&&null!=t.stateNode)Ho(0,t,e.memoizedProps,r);else{if("string"!=typeof r&&null===t.stateNode)throw Error(o(166));n=jl(kl.current),jl(Sl.current),Fl(t)?(r=t.stateNode,n=t.memoizedProps,r[Gr]=t,r.nodeValue!==n&&(t.flags|=4)):((r=(9===n.nodeType?n:n.ownerDocument).createTextNode(r))[Gr]=t,t.stateNode=r)}return null;case 13:return oa(Ol),r=t.memoizedState,0!=(64&t.flags)?(t.lanes=n,t):(r=null!==r,n=!1,null===e?void 0!==t.memoizedProps.fallback&&Fl(t):n=null!==e.memoizedState,r&&!n&&0!=(2&t.mode)&&(null===e&&!0!==t.memoizedProps.unstable_avoidThisFallback||0!=(1&Ol.current)?0===Di&&(Di=3):(0!==Di&&3!==Di||(Di=4),null===ki||0==(134217727&Ai)&&0==(134217727&_i)||du(ki,Ti))),(r||n)&&(t.flags|=4),null);case 4:return Cl(),null===e&&jr(t.stateNode.containerInfo),null;case 10:return Ja(t),null;case 17:return pa(t.type)&&ya(),null;case 19:if(oa(Ol),null===(r=t.memoizedState))return null;if(i=0!=(64&t.flags),null===(s=r.rendering))if(i)ei(r,!1);else{if(0!==Di||null!==e&&0!=(64&e.flags))for(e=t.child;null!==e;){if(null!==(s=zl(e))){for(t.flags|=64,ei(r,!1),null!==(i=s.updateQueue)&&(t.updateQueue=i,t.flags|=4),null===r.lastEffect&&(t.firstEffect=null),t.lastEffect=r.lastEffect,r=n,n=t.child;null!==n;)e=r,(i=n).flags&=2,i.nextEffect=null,i.firstEffect=null,i.lastEffect=null,null===(s=i.alternate)?(i.childLanes=0,i.lanes=e,i.child=null,i.memoizedProps=null,i.memoizedState=null,i.updateQueue=null,i.dependencies=null,i.stateNode=null):(i.childLanes=s.childLanes,i.lanes=s.lanes,i.child=s.child,i.memoizedProps=s.memoizedProps,i.memoizedState=s.memoizedState,i.updateQueue=s.updateQueue,i.type=s.type,e=s.dependencies,i.dependencies=null===e?null:{lanes:e.lanes,firstContext:e.firstContext}),n=n.sibling;return ia(Ol,1&Ol.current|2),t.child}e=e.sibling}null!==r.tail&&Ya()>Qi&&(t.flags|=64,i=!0,ei(r,!1),t.lanes=33554432)}else{if(!i)if(null!==(e=zl(s))){if(t.flags|=64,i=!0,null!==(n=e.updateQueue)&&(t.updateQueue=n,t.flags|=4),ei(r,!0),null===r.tail&&"hidden"===r.tailMode&&!s.alternate&&!Pl)return null!==(t=t.lastEffect=r.lastEffect)&&(t.nextEffect=null),null}else 2*Ya()-r.renderingStartTime>Qi&&1073741824!==n&&(t.flags|=64,i=!0,ei(r,!1),t.lanes=33554432);r.isBackwards?(s.sibling=t.child,t.child=s):(null!==(n=r.last)?n.sibling=s:t.child=s,r.last=s)}return null!==r.tail?(n=r.tail,r.rendering=n,r.tail=n.sibling,r.lastEffect=t.lastEffect,r.renderingStartTime=Ya(),n.sibling=null,t=Ol.current,ia(Ol,i?1&t|2:1&t),n):null;case 23:case 24:return mu(),null!==e&&null!==e.memoizedState!=(null!==t.memoizedState)&&"unstable-defer-without-hiding"!==r.mode&&(t.flags|=4),null}throw Error(o(156,t.tag))}function ni(e){switch(e.tag){case 1:pa(e.type)&&ya();var t=e.flags;return 4096&t?(e.flags=-4097&t|64,e):null;case 3:if(Cl(),oa(ca),oa(sa),Wl(),0!=(64&(t=e.flags)))throw Error(o(285));return e.flags=-4097&t|64,e;case 5:return Dl(e),null;case 13:return oa(Ol),4096&(t=e.flags)?(e.flags=-4097&t|64,e):null;case 19:return oa(Ol),null;case 4:return Cl(),null;case 10:return Ja(e),null;case 23:case 24:return mu(),null;default:return null}}function ri(e,t){try{var n="",r=t;do{n+=H(r),r=r.return}while(r);var a=n}catch(e){a="\nError generating stack: "+e.message+"\n"+e.stack}return{value:e,source:t,stack:a}}function ai(e,t){try{console.error(t.value)}catch(e){setTimeout((function(){throw e}))}}Bo=function(e,t){for(var n=t.child;null!==n;){if(5===n.tag||6===n.tag)e.appendChild(n.stateNode);else if(4!==n.tag&&null!==n.child){n.child.return=n,n=n.child;continue}if(n===t)break;for(;null===n.sibling;){if(null===n.return||n.return===t)return;n=n.return}n.sibling.return=n.return,n=n.sibling}},Wo=function(e,t,n,r){var l=e.memoizedProps;if(l!==r){e=t.stateNode,jl(Sl.current);var o,i=null;switch(n){case"input":l=J(e,l),r=J(e,r),i=[];break;case"option":l=le(e,l),r=le(e,r),i=[];break;case"select":l=a({},l,{value:void 0}),r=a({},r,{value:void 0}),i=[];break;case"textarea":l=ie(e,l),r=ie(e,r),i=[];break;default:"function"!=typeof l.onClick&&"function"==typeof r.onClick&&(e.onclick=_r)}for(f in Ne(n,r),n=null,l)if(!r.hasOwnProperty(f)&&l.hasOwnProperty(f)&&null!=l[f])if("style"===f){var s=l[f];for(o in s)s.hasOwnProperty(o)&&(n||(n={}),n[o]="")}else"dangerouslySetInnerHTML"!==f&&"children"!==f&&"suppressContentEditableWarning"!==f&&"suppressHydrationWarning"!==f&&"autoFocus"!==f&&(u.hasOwnProperty(f)?i||(i=[]):(i=i||[]).push(f,null));for(f in r){var c=r[f];if(s=null!=l?l[f]:void 0,r.hasOwnProperty(f)&&c!==s&&(null!=c||null!=s))if("style"===f)if(s){for(o in s)!s.hasOwnProperty(o)||c&&c.hasOwnProperty(o)||(n||(n={}),n[o]="");for(o in c)c.hasOwnProperty(o)&&s[o]!==c[o]&&(n||(n={}),n[o]=c[o])}else n||(i||(i=[]),i.push(f,n)),n=c;else"dangerouslySetInnerHTML"===f?(c=c?c.__html:void 0,s=s?s.__html:void 0,null!=c&&s!==c&&(i=i||[]).push(f,c)):"children"===f?"string"!=typeof c&&"number"!=typeof c||(i=i||[]).push(f,""+c):"suppressContentEditableWarning"!==f&&"suppressHydrationWarning"!==f&&(u.hasOwnProperty(f)?(null!=c&&"onScroll"===f&&xr("scroll",e),i||s===c||(i=[])):"object"==typeof c&&null!==c&&c.$$typeof===A?c.toString():(i=i||[]).push(f,c))}n&&(i=i||[]).push("style",n);var f=i;(t.updateQueue=f)&&(t.flags|=4)}},Ho=function(e,t,n,r){n!==r&&(t.flags|=4)};var li="function"==typeof WeakMap?WeakMap:Map;function oi(e,t,n){(n=ol(-1,n)).tag=3,n.payload={element:null};var r=t.value;return n.callback=function(){Bi||(Bi=!0,Wi=r),ai(0,t)},n}function ii(e,t,n){(n=ol(-1,n)).tag=3;var r=e.type.getDerivedStateFromError;if("function"==typeof r){var a=t.value;n.payload=function(){return ai(0,t),r(a)}}var l=e.stateNode;return null!==l&&"function"==typeof l.componentDidCatch&&(n.callback=function(){"function"!=typeof r&&(null===Hi?Hi=new Set([this]):Hi.add(this),ai(0,t));var e=t.stack;this.componentDidCatch(t.value,{componentStack:null!==e?e:""})}),n}var ui="function"==typeof WeakSet?WeakSet:Set;function si(e){var t=e.ref;if(null!==t)if("function"==typeof t)try{t(null)}catch(t){zu(e,t)}else t.current=null}function ci(e,t){switch(t.tag){case 0:case 11:case 15:case 22:return;case 1:if(256&t.flags&&null!==e){var n=e.memoizedProps,r=e.memoizedState;t=(e=t.stateNode).getSnapshotBeforeUpdate(t.elementType===t.type?n:Ka(t.type,n),r),e.__reactInternalSnapshotBeforeUpdate=t}return;case 3:return void(256&t.flags&&Vr(t.stateNode.containerInfo));case 5:case 6:case 4:case 17:return}throw Error(o(163))}function fi(e,t,n){switch(n.tag){case 0:case 11:case 15:case 22:if(null!==(t=null!==(t=n.updateQueue)?t.lastEffect:null)){e=t=t.next;do{if(3==(3&e.tag)){var r=e.create;e.destroy=r()}e=e.next}while(e!==t)}if(null!==(t=null!==(t=n.updateQueue)?t.lastEffect:null)){e=t=t.next;do{var a=e;r=a.next,0!=(4&(a=a.tag))&&0!=(1&a)&&(Iu(n,e),Cu(n,e)),e=r}while(e!==t)}return;case 1:return e=n.stateNode,4&n.flags&&(null===t?e.componentDidMount():(r=n.elementType===n.type?t.memoizedProps:Ka(n.type,t.memoizedProps),e.componentDidUpdate(r,t.memoizedState,e.__reactInternalSnapshotBeforeUpdate))),void(null!==(t=n.updateQueue)&&cl(n,t,e));case 3:if(null!==(t=n.updateQueue)){if(e=null,null!==n.child)switch(n.child.tag){case 5:e=n.child.stateNode;break;case 1:e=n.child.stateNode}cl(n,t,e)}return;case 5:return e=n.stateNode,void(null===t&&4&n.flags&&Yr(n.type,n.memoizedProps)&&e.focus());case 6:case 4:case 12:return;case 13:return void(null===n.memoizedState&&(n=n.alternate,null!==n&&(n=n.memoizedState,null!==n&&(n=n.dehydrated,null!==n&&Et(n)))));case 19:case 17:case 20:case 21:case 23:case 24:return}throw Error(o(163))}function di(e,t){for(var n=e;;){if(5===n.tag){var r=n.stateNode;if(t)"function"==typeof(r=r.style).setProperty?r.setProperty("display","none","important"):r.display="none";else{r=n.stateNode;var a=n.memoizedProps.style;a=null!=a&&a.hasOwnProperty("display")?a.display:null,r.style.display=Me("display",a)}}else if(6===n.tag)n.stateNode.nodeValue=t?"":n.memoizedProps;else if((23!==n.tag&&24!==n.tag||null===n.memoizedState||n===e)&&null!==n.child){n.child.return=n,n=n.child;continue}if(n===e)break;for(;null===n.sibling;){if(null===n.return||n.return===e)return;n=n.return}n.sibling.return=n.return,n=n.sibling}}function pi(e,t){if(Ma&&"function"==typeof Ma.onCommitFiberUnmount)try{Ma.onCommitFiberUnmount(ba,t)}catch(e){}switch(t.tag){case 0:case 11:case 14:case 15:case 22:if(null!==(e=t.updateQueue)&&null!==(e=e.lastEffect)){var n=e=e.next;do{var r=n,a=r.destroy;if(r=r.tag,void 0!==a)if(0!=(4&r))Iu(t,n);else{r=t;try{a()}catch(e){zu(r,e)}}n=n.next}while(n!==e)}break;case 1:if(si(t),"function"==typeof(e=t.stateNode).componentWillUnmount)try{e.props=t.memoizedProps,e.state=t.memoizedState,e.componentWillUnmount()}catch(e){zu(t,e)}break;case 5:si(t);break;case 4:bi(e,t)}}function yi(e){e.alternate=null,e.child=null,e.dependencies=null,e.firstEffect=null,e.lastEffect=null,e.memoizedProps=null,e.memoizedState=null,e.pendingProps=null,e.return=null,e.updateQueue=null}function hi(e){return 5===e.tag||3===e.tag||4===e.tag}function gi(e){e:{for(var t=e.return;null!==t;){if(hi(t))break e;t=t.return}throw Error(o(160))}var n=t;switch(t=n.stateNode,n.tag){case 5:var r=!1;break;case 3:case 4:t=t.containerInfo,r=!0;break;default:throw Error(o(161))}16&n.flags&&(me(t,""),n.flags&=-17);e:t:for(n=e;;){for(;null===n.sibling;){if(null===n.return||hi(n.return)){n=null;break e}n=n.return}for(n.sibling.return=n.return,n=n.sibling;5!==n.tag&&6!==n.tag&&18!==n.tag;){if(2&n.flags)continue t;if(null===n.child||4===n.tag)continue t;n.child.return=n,n=n.child}if(!(2&n.flags)){n=n.stateNode;break e}}r?mi(e,n,t):vi(e,n,t)}function mi(e,t,n){var r=e.tag,a=5===r||6===r;if(a)e=a?e.stateNode:e.stateNode.instance,t?8===n.nodeType?n.parentNode.insertBefore(e,t):n.insertBefore(e,t):(8===n.nodeType?(t=n.parentNode).insertBefore(e,n):(t=n).appendChild(e),null!=(n=n._reactRootContainer)||null!==t.onclick||(t.onclick=_r));else if(4!==r&&null!==(e=e.child))for(mi(e,t,n),e=e.sibling;null!==e;)mi(e,t,n),e=e.sibling}function vi(e,t,n){var r=e.tag,a=5===r||6===r;if(a)e=a?e.stateNode:e.stateNode.instance,t?n.insertBefore(e,t):n.appendChild(e);else if(4!==r&&null!==(e=e.child))for(vi(e,t,n),e=e.sibling;null!==e;)vi(e,t,n),e=e.sibling}function bi(e,t){for(var n,r,a=t,l=!1;;){if(!l){l=a.return;e:for(;;){if(null===l)throw Error(o(160));switch(n=l.stateNode,l.tag){case 5:r=!1;break e;case 3:case 4:n=n.containerInfo,r=!0;break e}l=l.return}l=!0}if(5===a.tag||6===a.tag){e:for(var i=e,u=a,s=u;;)if(pi(i,s),null!==s.child&&4!==s.tag)s.child.return=s,s=s.child;else{if(s===u)break e;for(;null===s.sibling;){if(null===s.return||s.return===u)break e;s=s.return}s.sibling.return=s.return,s=s.sibling}r?(i=n,u=a.stateNode,8===i.nodeType?i.parentNode.removeChild(u):i.removeChild(u)):n.removeChild(a.stateNode)}else if(4===a.tag){if(null!==a.child){n=a.stateNode.containerInfo,r=!0,a.child.return=a,a=a.child;continue}}else if(pi(e,a),null!==a.child){a.child.return=a,a=a.child;continue}if(a===t)break;for(;null===a.sibling;){if(null===a.return||a.return===t)return;4===(a=a.return).tag&&(l=!1)}a.sibling.return=a.return,a=a.sibling}}function Mi(e,t){switch(t.tag){case 0:case 11:case 14:case 15:case 22:var n=t.updateQueue;if(null!==(n=null!==n?n.lastEffect:null)){var r=n=n.next;do{3==(3&r.tag)&&(e=r.destroy,r.destroy=void 0,void 0!==e&&e()),r=r.next}while(r!==n)}return;case 1:return;case 5:if(null!=(n=t.stateNode)){r=t.memoizedProps;var a=null!==e?e.memoizedProps:r;e=t.type;var l=t.updateQueue;if(t.updateQueue=null,null!==l){for(n[$r]=r,"input"===e&&"radio"===r.type&&null!=r.name&&te(n,r),we(e,a),t=we(e,r),a=0;a<l.length;a+=2){var i=l[a],u=l[a+1];"style"===i?Ee(n,u):"dangerouslySetInnerHTML"===i?ge(n,u):"children"===i?me(n,u):M(n,i,u,t)}switch(e){case"input":ne(n,r);break;case"textarea":se(n,r);break;case"select":e=n._wrapperState.wasMultiple,n._wrapperState.wasMultiple=!!r.multiple,null!=(l=r.value)?oe(n,!!r.multiple,l,!1):e!==!!r.multiple&&(null!=r.defaultValue?oe(n,!!r.multiple,r.defaultValue,!0):oe(n,!!r.multiple,r.multiple?[]:"",!1))}}}return;case 6:if(null===t.stateNode)throw Error(o(162));return void(t.stateNode.nodeValue=t.memoizedProps);case 3:return void((n=t.stateNode).hydrate&&(n.hydrate=!1,Et(n.containerInfo)));case 12:return;case 13:return null!==t.memoizedState&&(Yi=Ya(),di(t.child,!0)),void Ei(t);case 19:return void Ei(t);case 17:return;case 23:case 24:return void di(t,null!==t.memoizedState)}throw Error(o(163))}function Ei(e){var t=e.updateQueue;if(null!==t){e.updateQueue=null;var n=e.stateNode;null===n&&(n=e.stateNode=new ui),t.forEach((function(t){var r=_u.bind(null,e,t);n.has(t)||(n.add(t),t.then(r,r))}))}}function Li(e,t){return null!==e&&(null===(e=e.memoizedState)||null!==e.dehydrated)&&null!==(t=t.memoizedState)&&null===t.dehydrated}var Ni=Math.ceil,wi=E.ReactCurrentDispatcher,Si=E.ReactCurrentOwner,xi=0,ki=null,ji=null,Ti=0,Ci=0,Ii=la(0),Di=0,Oi=null,zi=0,Ai=0,_i=0,Pi=0,Ui=null,Yi=0,Qi=1/0;function Ri(){Qi=Ya()+500}var Fi,Vi=null,Bi=!1,Wi=null,Hi=null,Ki=!1,Gi=null,$i=90,qi=[],Zi=[],Xi=null,Ji=0,eu=null,tu=-1,nu=0,ru=0,au=null,lu=!1;function ou(){return 0!=(48&xi)?Ya():-1!==tu?tu:tu=Ya()}function iu(e){if(0==(2&(e=e.mode)))return 1;if(0==(4&e))return 99===Qa()?1:2;if(0===nu&&(nu=zi),0!==Ha.transition){0!==ru&&(ru=null!==Ui?Ui.pendingLanes:0),e=nu;var t=4186112&~ru;return 0==(t&=-t)&&0==(t=(e=4186112&~e)&-e)&&(t=8192),t}return e=Qa(),e=Yt(0!=(4&xi)&&98===e?12:e=function(e){switch(e){case 99:return 15;case 98:return 10;case 97:case 96:return 8;case 95:return 2;default:return 0}}(e),nu)}function uu(e,t,n){if(50<Ji)throw Ji=0,eu=null,Error(o(185));if(null===(e=su(e,t)))return null;Ft(e,t,n),e===ki&&(_i|=t,4===Di&&du(e,Ti));var r=Qa();1===t?0!=(8&xi)&&0==(48&xi)?pu(e):(cu(e,n),0===xi&&(Ri(),Ba())):(0==(4&xi)||98!==r&&99!==r||(null===Xi?Xi=new Set([e]):Xi.add(e)),cu(e,n)),Ui=e}function su(e,t){e.lanes|=t;var n=e.alternate;for(null!==n&&(n.lanes|=t),n=e,e=e.return;null!==e;)e.childLanes|=t,null!==(n=e.alternate)&&(n.childLanes|=t),n=e,e=e.return;return 3===n.tag?n.stateNode:null}function cu(e,t){for(var n=e.callbackNode,r=e.suspendedLanes,a=e.pingedLanes,l=e.expirationTimes,i=e.pendingLanes;0<i;){var u=31-Vt(i),s=1<<u,c=l[u];if(-1===c){if(0==(s&r)||0!=(s&a)){c=t,_t(s);var f=At;l[u]=10<=f?c+250:6<=f?c+5e3:-1}}else c<=t&&(e.expiredLanes|=s);i&=~s}if(r=Pt(e,e===ki?Ti:0),t=At,0===r)null!==n&&(n!==Oa&&Na(n),e.callbackNode=null,e.callbackPriority=0);else{if(null!==n){if(e.callbackPriority===t)return;n!==Oa&&Na(n)}15===t?(n=pu.bind(null,e),null===Aa?(Aa=[n],_a=La(ja,Wa)):Aa.push(n),n=Oa):n=14===t?Va(99,pu.bind(null,e)):Va(n=function(e){switch(e){case 15:case 14:return 99;case 13:case 12:case 11:case 10:return 98;case 9:case 8:case 7:case 6:case 4:case 5:return 97;case 3:case 2:case 1:return 95;case 0:return 90;default:throw Error(o(358,e))}}(t),fu.bind(null,e)),e.callbackPriority=t,e.callbackNode=n}}function fu(e){if(tu=-1,ru=nu=0,0!=(48&xi))throw Error(o(327));var t=e.callbackNode;if(Tu()&&e.callbackNode!==t)return null;var n=Pt(e,e===ki?Ti:0);if(0===n)return null;var r=n,a=xi;xi|=16;var l=Mu();for(ki===e&&Ti===r||(Ri(),vu(e,r));;)try{Nu();break}catch(t){bu(e,t)}if(Xa(),wi.current=l,xi=a,null!==ji?r=0:(ki=null,Ti=0,r=Di),0!=(zi&_i))vu(e,0);else if(0!==r){if(2===r&&(xi|=64,e.hydrate&&(e.hydrate=!1,Vr(e.containerInfo)),0!==(n=Ut(e))&&(r=Eu(e,n))),1===r)throw t=Oi,vu(e,0),du(e,n),cu(e,Ya()),t;switch(e.finishedWork=e.current.alternate,e.finishedLanes=n,r){case 0:case 1:throw Error(o(345));case 2:xu(e);break;case 3:if(du(e,n),(62914560&n)===n&&10<(r=Yi+500-Ya())){if(0!==Pt(e,0))break;if(((a=e.suspendedLanes)&n)!==n){ou(),e.pingedLanes|=e.suspendedLanes&a;break}e.timeoutHandle=Rr(xu.bind(null,e),r);break}xu(e);break;case 4:if(du(e,n),(4186112&n)===n)break;for(r=e.eventTimes,a=-1;0<n;){var i=31-Vt(n);l=1<<i,(i=r[i])>a&&(a=i),n&=~l}if(n=a,10<(n=(120>(n=Ya()-n)?120:480>n?480:1080>n?1080:1920>n?1920:3e3>n?3e3:4320>n?4320:1960*Ni(n/1960))-n)){e.timeoutHandle=Rr(xu.bind(null,e),n);break}xu(e);break;case 5:xu(e);break;default:throw Error(o(329))}}return cu(e,Ya()),e.callbackNode===t?fu.bind(null,e):null}function du(e,t){for(t&=~Pi,t&=~_i,e.suspendedLanes|=t,e.pingedLanes&=~t,e=e.expirationTimes;0<t;){var n=31-Vt(t),r=1<<n;e[n]=-1,t&=~r}}function pu(e){if(0!=(48&xi))throw Error(o(327));if(Tu(),e===ki&&0!=(e.expiredLanes&Ti)){var t=Ti,n=Eu(e,t);0!=(zi&_i)&&(n=Eu(e,t=Pt(e,t)))}else n=Eu(e,t=Pt(e,0));if(0!==e.tag&&2===n&&(xi|=64,e.hydrate&&(e.hydrate=!1,Vr(e.containerInfo)),0!==(t=Ut(e))&&(n=Eu(e,t))),1===n)throw n=Oi,vu(e,0),du(e,t),cu(e,Ya()),n;return e.finishedWork=e.current.alternate,e.finishedLanes=t,xu(e),cu(e,Ya()),null}function yu(e,t){var n=xi;xi|=1;try{return e(t)}finally{0===(xi=n)&&(Ri(),Ba())}}function hu(e,t){var n=xi;xi&=-2,xi|=8;try{return e(t)}finally{0===(xi=n)&&(Ri(),Ba())}}function gu(e,t){ia(Ii,Ci),Ci|=t,zi|=t}function mu(){Ci=Ii.current,oa(Ii)}function vu(e,t){e.finishedWork=null,e.finishedLanes=0;var n=e.timeoutHandle;if(-1!==n&&(e.timeoutHandle=-1,Fr(n)),null!==ji)for(n=ji.return;null!==n;){var r=n;switch(r.tag){case 1:null!=(r=r.type.childContextTypes)&&ya();break;case 3:Cl(),oa(ca),oa(sa),Wl();break;case 5:Dl(r);break;case 4:Cl();break;case 13:case 19:oa(Ol);break;case 10:Ja(r);break;case 23:case 24:mu()}n=n.return}ki=e,ji=Qu(e.current,null),Ti=Ci=zi=t,Di=0,Oi=null,Pi=_i=Ai=0}function bu(e,t){for(;;){var n=ji;try{if(Xa(),Hl.current=jo,Xl){for(var r=$l.memoizedState;null!==r;){var a=r.queue;null!==a&&(a.pending=null),r=r.next}Xl=!1}if(Gl=0,Zl=ql=$l=null,Jl=!1,Si.current=null,null===n||null===n.return){Di=1,Oi=t,ji=null;break}e:{var l=e,o=n.return,i=n,u=t;if(t=Ti,i.flags|=2048,i.firstEffect=i.lastEffect=null,null!==u&&"object"==typeof u&&"function"==typeof u.then){var s=u;if(0==(2&i.mode)){var c=i.alternate;c?(i.updateQueue=c.updateQueue,i.memoizedState=c.memoizedState,i.lanes=c.lanes):(i.updateQueue=null,i.memoizedState=null)}var f=0!=(1&Ol.current),d=o;do{var p;if(p=13===d.tag){var y=d.memoizedState;if(null!==y)p=null!==y.dehydrated;else{var h=d.memoizedProps;p=void 0!==h.fallback&&(!0!==h.unstable_avoidThisFallback||!f)}}if(p){var g=d.updateQueue;if(null===g){var m=new Set;m.add(s),d.updateQueue=m}else g.add(s);if(0==(2&d.mode)){if(d.flags|=64,i.flags|=16384,i.flags&=-2981,1===i.tag)if(null===i.alternate)i.tag=17;else{var v=ol(-1,1);v.tag=2,il(i,v)}i.lanes|=1;break e}u=void 0,i=t;var b=l.pingCache;if(null===b?(b=l.pingCache=new li,u=new Set,b.set(s,u)):void 0===(u=b.get(s))&&(u=new Set,b.set(s,u)),!u.has(i)){u.add(i);var M=Au.bind(null,l,s,i);s.then(M,M)}d.flags|=4096,d.lanes=t;break e}d=d.return}while(null!==d);u=Error((K(i.type)||"A React component")+" suspended while rendering, but no fallback UI was specified.\n\nAdd a <Suspense fallback=...> component higher in the tree to provide a loading indicator or placeholder to display.")}5!==Di&&(Di=2),u=ri(u,i),d=o;do{switch(d.tag){case 3:l=u,d.flags|=4096,t&=-t,d.lanes|=t,ul(d,oi(0,l,t));break e;case 1:l=u;var E=d.type,L=d.stateNode;if(0==(64&d.flags)&&("function"==typeof E.getDerivedStateFromError||null!==L&&"function"==typeof L.componentDidCatch&&(null===Hi||!Hi.has(L)))){d.flags|=4096,t&=-t,d.lanes|=t,ul(d,ii(d,l,t));break e}}d=d.return}while(null!==d)}Su(n)}catch(e){t=e,ji===n&&null!==n&&(ji=n=n.return);continue}break}}function Mu(){var e=wi.current;return wi.current=jo,null===e?jo:e}function Eu(e,t){var n=xi;xi|=16;var r=Mu();for(ki===e&&Ti===t||vu(e,t);;)try{Lu();break}catch(t){bu(e,t)}if(Xa(),xi=n,wi.current=r,null!==ji)throw Error(o(261));return ki=null,Ti=0,Di}function Lu(){for(;null!==ji;)wu(ji)}function Nu(){for(;null!==ji&&!wa();)wu(ji)}function wu(e){var t=Fi(e.alternate,e,Ci);e.memoizedProps=e.pendingProps,null===t?Su(e):ji=t,Si.current=null}function Su(e){var t=e;do{var n=t.alternate;if(e=t.return,0==(2048&t.flags)){if(null!==(n=ti(n,t,Ci)))return void(ji=n);if(24!==(n=t).tag&&23!==n.tag||null===n.memoizedState||0!=(1073741824&Ci)||0==(4&n.mode)){for(var r=0,a=n.child;null!==a;)r|=a.lanes|a.childLanes,a=a.sibling;n.childLanes=r}null!==e&&0==(2048&e.flags)&&(null===e.firstEffect&&(e.firstEffect=t.firstEffect),null!==t.lastEffect&&(null!==e.lastEffect&&(e.lastEffect.nextEffect=t.firstEffect),e.lastEffect=t.lastEffect),1<t.flags&&(null!==e.lastEffect?e.lastEffect.nextEffect=t:e.firstEffect=t,e.lastEffect=t))}else{if(null!==(n=ni(t)))return n.flags&=2047,void(ji=n);null!==e&&(e.firstEffect=e.lastEffect=null,e.flags|=2048)}if(null!==(t=t.sibling))return void(ji=t);ji=t=e}while(null!==t);0===Di&&(Di=5)}function xu(e){var t=Qa();return Fa(99,ku.bind(null,e,t)),null}function ku(e,t){do{Tu()}while(null!==Gi);if(0!=(48&xi))throw Error(o(327));var n=e.finishedWork;if(null===n)return null;if(e.finishedWork=null,e.finishedLanes=0,n===e.current)throw Error(o(177));e.callbackNode=null;var r=n.lanes|n.childLanes,a=r,l=e.pendingLanes&~a;e.pendingLanes=a,e.suspendedLanes=0,e.pingedLanes=0,e.expiredLanes&=a,e.mutableReadLanes&=a,e.entangledLanes&=a,a=e.entanglements;for(var i=e.eventTimes,u=e.expirationTimes;0<l;){var s=31-Vt(l),c=1<<s;a[s]=0,i[s]=-1,u[s]=-1,l&=~c}if(null!==Xi&&0==(24&r)&&Xi.has(e)&&Xi.delete(e),e===ki&&(ji=ki=null,Ti=0),1<n.flags?null!==n.lastEffect?(n.lastEffect.nextEffect=n,r=n.firstEffect):r=n:r=n.firstEffect,null!==r){if(a=xi,xi|=32,Si.current=null,Pr=Gt,pr(i=dr())){if("selectionStart"in i)u={start:i.selectionStart,end:i.selectionEnd};else e:if(u=(u=i.ownerDocument)&&u.defaultView||window,(c=u.getSelection&&u.getSelection())&&0!==c.rangeCount){u=c.anchorNode,l=c.anchorOffset,s=c.focusNode,c=c.focusOffset;try{u.nodeType,s.nodeType}catch(e){u=null;break e}var f=0,d=-1,p=-1,y=0,h=0,g=i,m=null;t:for(;;){for(var v;g!==u||0!==l&&3!==g.nodeType||(d=f+l),g!==s||0!==c&&3!==g.nodeType||(p=f+c),3===g.nodeType&&(f+=g.nodeValue.length),null!==(v=g.firstChild);)m=g,g=v;for(;;){if(g===i)break t;if(m===u&&++y===l&&(d=f),m===s&&++h===c&&(p=f),null!==(v=g.nextSibling))break;m=(g=m).parentNode}g=v}u=-1===d||-1===p?null:{start:d,end:p}}else u=null;u=u||{start:0,end:0}}else u=null;Ur={focusedElem:i,selectionRange:u},Gt=!1,au=null,lu=!1,Vi=r;do{try{ju()}catch(e){if(null===Vi)throw Error(o(330));zu(Vi,e),Vi=Vi.nextEffect}}while(null!==Vi);au=null,Vi=r;do{try{for(i=e;null!==Vi;){var b=Vi.flags;if(16&b&&me(Vi.stateNode,""),128&b){var M=Vi.alternate;if(null!==M){var E=M.ref;null!==E&&("function"==typeof E?E(null):E.current=null)}}switch(1038&b){case 2:gi(Vi),Vi.flags&=-3;break;case 6:gi(Vi),Vi.flags&=-3,Mi(Vi.alternate,Vi);break;case 1024:Vi.flags&=-1025;break;case 1028:Vi.flags&=-1025,Mi(Vi.alternate,Vi);break;case 4:Mi(Vi.alternate,Vi);break;case 8:bi(i,u=Vi);var L=u.alternate;yi(u),null!==L&&yi(L)}Vi=Vi.nextEffect}}catch(e){if(null===Vi)throw Error(o(330));zu(Vi,e),Vi=Vi.nextEffect}}while(null!==Vi);if(E=Ur,M=dr(),b=E.focusedElem,i=E.selectionRange,M!==b&&b&&b.ownerDocument&&fr(b.ownerDocument.documentElement,b)){null!==i&&pr(b)&&(M=i.start,void 0===(E=i.end)&&(E=M),"selectionStart"in b?(b.selectionStart=M,b.selectionEnd=Math.min(E,b.value.length)):(E=(M=b.ownerDocument||document)&&M.defaultView||window).getSelection&&(E=E.getSelection(),u=b.textContent.length,L=Math.min(i.start,u),i=void 0===i.end?L:Math.min(i.end,u),!E.extend&&L>i&&(u=i,i=L,L=u),u=cr(b,L),l=cr(b,i),u&&l&&(1!==E.rangeCount||E.anchorNode!==u.node||E.anchorOffset!==u.offset||E.focusNode!==l.node||E.focusOffset!==l.offset)&&((M=M.createRange()).setStart(u.node,u.offset),E.removeAllRanges(),L>i?(E.addRange(M),E.extend(l.node,l.offset)):(M.setEnd(l.node,l.offset),E.addRange(M))))),M=[];for(E=b;E=E.parentNode;)1===E.nodeType&&M.push({element:E,left:E.scrollLeft,top:E.scrollTop});for("function"==typeof b.focus&&b.focus(),b=0;b<M.length;b++)(E=M[b]).element.scrollLeft=E.left,E.element.scrollTop=E.top}Gt=!!Pr,Ur=Pr=null,e.current=n,Vi=r;do{try{for(b=e;null!==Vi;){var N=Vi.flags;if(36&N&&fi(b,Vi.alternate,Vi),128&N){M=void 0;var w=Vi.ref;if(null!==w){var S=Vi.stateNode;switch(Vi.tag){case 5:M=S;break;default:M=S}"function"==typeof w?w(M):w.current=M}}Vi=Vi.nextEffect}}catch(e){if(null===Vi)throw Error(o(330));zu(Vi,e),Vi=Vi.nextEffect}}while(null!==Vi);Vi=null,za(),xi=a}else e.current=n;if(Ki)Ki=!1,Gi=e,$i=t;else for(Vi=r;null!==Vi;)t=Vi.nextEffect,Vi.nextEffect=null,8&Vi.flags&&((N=Vi).sibling=null,N.stateNode=null),Vi=t;if(0===(r=e.pendingLanes)&&(Hi=null),1===r?e===eu?Ji++:(Ji=0,eu=e):Ji=0,n=n.stateNode,Ma&&"function"==typeof Ma.onCommitFiberRoot)try{Ma.onCommitFiberRoot(ba,n,void 0,64==(64&n.current.flags))}catch(e){}if(cu(e,Ya()),Bi)throw Bi=!1,e=Wi,Wi=null,e;return 0!=(8&xi)||Ba(),null}function ju(){for(;null!==Vi;){var e=Vi.alternate;lu||null===au||(0!=(8&Vi.flags)?Je(Vi,au)&&(lu=!0):13===Vi.tag&&Li(e,Vi)&&Je(Vi,au)&&(lu=!0));var t=Vi.flags;0!=(256&t)&&ci(e,Vi),0==(512&t)||Ki||(Ki=!0,Va(97,(function(){return Tu(),null}))),Vi=Vi.nextEffect}}function Tu(){if(90!==$i){var e=97<$i?97:$i;return $i=90,Fa(e,Du)}return!1}function Cu(e,t){qi.push(t,e),Ki||(Ki=!0,Va(97,(function(){return Tu(),null})))}function Iu(e,t){Zi.push(t,e),Ki||(Ki=!0,Va(97,(function(){return Tu(),null})))}function Du(){if(null===Gi)return!1;var e=Gi;if(Gi=null,0!=(48&xi))throw Error(o(331));var t=xi;xi|=32;var n=Zi;Zi=[];for(var r=0;r<n.length;r+=2){var a=n[r],l=n[r+1],i=a.destroy;if(a.destroy=void 0,"function"==typeof i)try{i()}catch(e){if(null===l)throw Error(o(330));zu(l,e)}}for(n=qi,qi=[],r=0;r<n.length;r+=2){a=n[r],l=n[r+1];try{var u=a.create;a.destroy=u()}catch(e){if(null===l)throw Error(o(330));zu(l,e)}}for(u=e.current.firstEffect;null!==u;)e=u.nextEffect,u.nextEffect=null,8&u.flags&&(u.sibling=null,u.stateNode=null),u=e;return xi=t,Ba(),!0}function Ou(e,t,n){il(e,t=oi(0,t=ri(n,t),1)),t=ou(),null!==(e=su(e,1))&&(Ft(e,1,t),cu(e,t))}function zu(e,t){if(3===e.tag)Ou(e,e,t);else for(var n=e.return;null!==n;){if(3===n.tag){Ou(n,e,t);break}if(1===n.tag){var r=n.stateNode;if("function"==typeof n.type.getDerivedStateFromError||"function"==typeof r.componentDidCatch&&(null===Hi||!Hi.has(r))){var a=ii(n,e=ri(t,e),1);if(il(n,a),a=ou(),null!==(n=su(n,1)))Ft(n,1,a),cu(n,a);else if("function"==typeof r.componentDidCatch&&(null===Hi||!Hi.has(r)))try{r.componentDidCatch(t,e)}catch(e){}break}}n=n.return}}function Au(e,t,n){var r=e.pingCache;null!==r&&r.delete(t),t=ou(),e.pingedLanes|=e.suspendedLanes&n,ki===e&&(Ti&n)===n&&(4===Di||3===Di&&(62914560&Ti)===Ti&&500>Ya()-Yi?vu(e,0):Pi|=n),cu(e,t)}function _u(e,t){var n=e.stateNode;null!==n&&n.delete(t),0==(t=0)&&(0==(2&(t=e.mode))?t=1:0==(4&t)?t=99===Qa()?1:2:(0===nu&&(nu=zi),0===(t=Qt(62914560&~nu))&&(t=4194304))),n=ou(),null!==(e=su(e,t))&&(Ft(e,t,n),cu(e,n))}function Pu(e,t,n,r){this.tag=e,this.key=n,this.sibling=this.child=this.return=this.stateNode=this.type=this.elementType=null,this.index=0,this.ref=null,this.pendingProps=t,this.dependencies=this.memoizedState=this.updateQueue=this.memoizedProps=null,this.mode=r,this.flags=0,this.lastEffect=this.firstEffect=this.nextEffect=null,this.childLanes=this.lanes=0,this.alternate=null}function Uu(e,t,n,r){return new Pu(e,t,n,r)}function Yu(e){return!(!(e=e.prototype)||!e.isReactComponent)}function Qu(e,t){var n=e.alternate;return null===n?((n=Uu(e.tag,t,e.key,e.mode)).elementType=e.elementType,n.type=e.type,n.stateNode=e.stateNode,n.alternate=e,e.alternate=n):(n.pendingProps=t,n.type=e.type,n.flags=0,n.nextEffect=null,n.firstEffect=null,n.lastEffect=null),n.childLanes=e.childLanes,n.lanes=e.lanes,n.child=e.child,n.memoizedProps=e.memoizedProps,n.memoizedState=e.memoizedState,n.updateQueue=e.updateQueue,t=e.dependencies,n.dependencies=null===t?null:{lanes:t.lanes,firstContext:t.firstContext},n.sibling=e.sibling,n.index=e.index,n.ref=e.ref,n}function Ru(e,t,n,r,a,l){var i=2;if(r=e,"function"==typeof e)Yu(e)&&(i=1);else if("string"==typeof e)i=5;else e:switch(e){case w:return Fu(n.children,a,l,t);case _:i=8,a|=16;break;case S:i=8,a|=1;break;case x:return(e=Uu(12,n,t,8|a)).elementType=x,e.type=x,e.lanes=l,e;case C:return(e=Uu(13,n,t,a)).type=C,e.elementType=C,e.lanes=l,e;case I:return(e=Uu(19,n,t,a)).elementType=I,e.lanes=l,e;case P:return Vu(n,a,l,t);case U:return(e=Uu(24,n,t,a)).elementType=U,e.lanes=l,e;default:if("object"==typeof e&&null!==e)switch(e.$$typeof){case k:i=10;break e;case j:i=9;break e;case T:i=11;break e;case D:i=14;break e;case O:i=16,r=null;break e;case z:i=22;break e}throw Error(o(130,null==e?e:typeof e,""))}return(t=Uu(i,n,t,a)).elementType=e,t.type=r,t.lanes=l,t}function Fu(e,t,n,r){return(e=Uu(7,e,r,t)).lanes=n,e}function Vu(e,t,n,r){return(e=Uu(23,e,r,t)).elementType=P,e.lanes=n,e}function Bu(e,t,n){return(e=Uu(6,e,null,t)).lanes=n,e}function Wu(e,t,n){return(t=Uu(4,null!==e.children?e.children:[],e.key,t)).lanes=n,t.stateNode={containerInfo:e.containerInfo,pendingChildren:null,implementation:e.implementation},t}function Hu(e,t,n){this.tag=t,this.containerInfo=e,this.finishedWork=this.pingCache=this.current=this.pendingChildren=null,this.timeoutHandle=-1,this.pendingContext=this.context=null,this.hydrate=n,this.callbackNode=null,this.callbackPriority=0,this.eventTimes=Rt(0),this.expirationTimes=Rt(-1),this.entangledLanes=this.finishedLanes=this.mutableReadLanes=this.expiredLanes=this.pingedLanes=this.suspendedLanes=this.pendingLanes=0,this.entanglements=Rt(0),this.mutableSourceEagerHydrationData=null}function Ku(e,t,n){var r=3<arguments.length&&void 0!==arguments[3]?arguments[3]:null;return{$$typeof:N,key:null==r?null:""+r,children:e,containerInfo:t,implementation:n}}function Gu(e,t,n,r){var a=t.current,l=ou(),i=iu(a);e:if(n){t:{if($e(n=n._reactInternals)!==n||1!==n.tag)throw Error(o(170));var u=n;do{switch(u.tag){case 3:u=u.stateNode.context;break t;case 1:if(pa(u.type)){u=u.stateNode.__reactInternalMemoizedMergedChildContext;break t}}u=u.return}while(null!==u);throw Error(o(171))}if(1===n.tag){var s=n.type;if(pa(s)){n=ga(n,s,u);break e}}n=u}else n=ua;return null===t.context?t.context=n:t.pendingContext=n,(t=ol(l,i)).payload={element:e},null!==(r=void 0===r?null:r)&&(t.callback=r),il(a,t),uu(a,i,l),i}function $u(e){if(!(e=e.current).child)return null;switch(e.child.tag){case 5:default:return e.child.stateNode}}function qu(e,t){if(null!==(e=e.memoizedState)&&null!==e.dehydrated){var n=e.retryLane;e.retryLane=0!==n&&n<t?n:t}}function Zu(e,t){qu(e,t),(e=e.alternate)&&qu(e,t)}function Xu(e,t,n){var r=null!=n&&null!=n.hydrationOptions&&n.hydrationOptions.mutableSources||null;if(n=new Hu(e,t,null!=n&&!0===n.hydrate),t=Uu(3,null,null,2===t?7:1===t?3:0),n.current=t,t.stateNode=n,al(t),e[qr]=n.current,jr(8===e.nodeType?e.parentNode:e),r)for(e=0;e<r.length;e++){var a=(t=r[e])._getVersion;a=a(t._source),null==n.mutableSourceEagerHydrationData?n.mutableSourceEagerHydrationData=[t,a]:n.mutableSourceEagerHydrationData.push(t,a)}this._internalRoot=n}function Ju(e){return!(!e||1!==e.nodeType&&9!==e.nodeType&&11!==e.nodeType&&(8!==e.nodeType||" react-mount-point-unstable "!==e.nodeValue))}function es(e,t,n,r,a){var l=n._reactRootContainer;if(l){var o=l._internalRoot;if("function"==typeof a){var i=a;a=function(){var e=$u(o);i.call(e)}}Gu(t,o,e,a)}else{if(l=n._reactRootContainer=function(e,t){if(t||(t=!(!(t=e?9===e.nodeType?e.documentElement:e.firstChild:null)||1!==t.nodeType||!t.hasAttribute("data-reactroot"))),!t)for(var n;n=e.lastChild;)e.removeChild(n);return new Xu(e,0,t?{hydrate:!0}:void 0)}(n,r),o=l._internalRoot,"function"==typeof a){var u=a;a=function(){var e=$u(o);u.call(e)}}hu((function(){Gu(t,o,e,a)}))}return $u(o)}function ts(e,t){var n=2<arguments.length&&void 0!==arguments[2]?arguments[2]:null;if(!Ju(t))throw Error(o(200));return Ku(e,t,null,n)}Fi=function(e,t,n){var r=t.lanes;if(null!==e)if(e.memoizedProps!==t.pendingProps||ca.current)Oo=!0;else{if(0==(n&r)){switch(Oo=!1,t.tag){case 3:Vo(t),Vl();break;case 5:Il(t);break;case 1:pa(t.type)&&ma(t);break;case 4:Tl(t,t.stateNode.containerInfo);break;case 10:r=t.memoizedProps.value;var a=t.type._context;ia(Ga,a._currentValue),a._currentValue=r;break;case 13:if(null!==t.memoizedState)return 0!=(n&t.child.childLanes)?Go(e,t,n):(ia(Ol,1&Ol.current),null!==(t=Jo(e,t,n))?t.sibling:null);ia(Ol,1&Ol.current);break;case 19:if(r=0!=(n&t.childLanes),0!=(64&e.flags)){if(r)return Xo(e,t,n);t.flags|=64}if(null!==(a=t.memoizedState)&&(a.rendering=null,a.tail=null,a.lastEffect=null),ia(Ol,Ol.current),r)break;return null;case 23:case 24:return t.lanes=0,Uo(e,t,n)}return Jo(e,t,n)}Oo=0!=(16384&e.flags)}else Oo=!1;switch(t.lanes=0,t.tag){case 2:if(r=t.type,null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),e=t.pendingProps,a=da(t,sa.current),tl(t,n),a=no(null,t,r,e,a,n),t.flags|=1,"object"==typeof a&&null!==a&&"function"==typeof a.render&&void 0===a.$$typeof){if(t.tag=1,t.memoizedState=null,t.updateQueue=null,pa(r)){var l=!0;ma(t)}else l=!1;t.memoizedState=null!==a.state&&void 0!==a.state?a.state:null,al(t);var i=r.getDerivedStateFromProps;"function"==typeof i&&dl(t,r,i,e),a.updater=pl,t.stateNode=a,a._reactInternals=t,ml(t,r,e,n),t=Fo(null,t,r,!0,l,n)}else t.tag=0,zo(null,t,a,n),t=t.child;return t;case 16:a=t.elementType;e:{switch(null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),e=t.pendingProps,a=(l=a._init)(a._payload),t.type=a,l=t.tag=function(e){if("function"==typeof e)return Yu(e)?1:0;if(null!=e){if((e=e.$$typeof)===T)return 11;if(e===D)return 14}return 2}(a),e=Ka(a,e),l){case 0:t=Qo(null,t,a,e,n);break e;case 1:t=Ro(null,t,a,e,n);break e;case 11:t=Ao(null,t,a,e,n);break e;case 14:t=_o(null,t,a,Ka(a.type,e),r,n);break e}throw Error(o(306,a,""))}return t;case 0:return r=t.type,a=t.pendingProps,Qo(e,t,r,a=t.elementType===r?a:Ka(r,a),n);case 1:return r=t.type,a=t.pendingProps,Ro(e,t,r,a=t.elementType===r?a:Ka(r,a),n);case 3:if(Vo(t),r=t.updateQueue,null===e||null===r)throw Error(o(282));if(r=t.pendingProps,a=null!==(a=t.memoizedState)?a.element:null,ll(e,t),sl(t,r,null,n),(r=t.memoizedState.element)===a)Vl(),t=Jo(e,t,n);else{if((l=(a=t.stateNode).hydrate)&&(_l=Br(t.stateNode.containerInfo.firstChild),Al=t,l=Pl=!0),l){if(null!=(e=a.mutableSourceEagerHydrationData))for(a=0;a<e.length;a+=2)(l=e[a])._workInProgressVersionPrimary=e[a+1],Bl.push(l);for(n=Nl(t,null,r,n),t.child=n;n;)n.flags=-3&n.flags|1024,n=n.sibling}else zo(e,t,r,n),Vl();t=t.child}return t;case 5:return Il(t),null===e&&Ql(t),r=t.type,a=t.pendingProps,l=null!==e?e.memoizedProps:null,i=a.children,Qr(r,a)?i=null:null!==l&&Qr(r,l)&&(t.flags|=16),Yo(e,t),zo(e,t,i,n),t.child;case 6:return null===e&&Ql(t),null;case 13:return Go(e,t,n);case 4:return Tl(t,t.stateNode.containerInfo),r=t.pendingProps,null===e?t.child=Ll(t,null,r,n):zo(e,t,r,n),t.child;case 11:return r=t.type,a=t.pendingProps,Ao(e,t,r,a=t.elementType===r?a:Ka(r,a),n);case 7:return zo(e,t,t.pendingProps,n),t.child;case 8:case 12:return zo(e,t,t.pendingProps.children,n),t.child;case 10:e:{r=t.type._context,a=t.pendingProps,i=t.memoizedProps,l=a.value;var u=t.type._context;if(ia(Ga,u._currentValue),u._currentValue=l,null!==i)if(u=i.value,0==(l=or(u,l)?0:0|("function"==typeof r._calculateChangedBits?r._calculateChangedBits(u,l):1073741823))){if(i.children===a.children&&!ca.current){t=Jo(e,t,n);break e}}else for(null!==(u=t.child)&&(u.return=t);null!==u;){var s=u.dependencies;if(null!==s){i=u.child;for(var c=s.firstContext;null!==c;){if(c.context===r&&0!=(c.observedBits&l)){1===u.tag&&((c=ol(-1,n&-n)).tag=2,il(u,c)),u.lanes|=n,null!==(c=u.alternate)&&(c.lanes|=n),el(u.return,n),s.lanes|=n;break}c=c.next}}else i=10===u.tag&&u.type===t.type?null:u.child;if(null!==i)i.return=u;else for(i=u;null!==i;){if(i===t){i=null;break}if(null!==(u=i.sibling)){u.return=i.return,i=u;break}i=i.return}u=i}zo(e,t,a.children,n),t=t.child}return t;case 9:return a=t.type,r=(l=t.pendingProps).children,tl(t,n),r=r(a=nl(a,l.unstable_observedBits)),t.flags|=1,zo(e,t,r,n),t.child;case 14:return l=Ka(a=t.type,t.pendingProps),_o(e,t,a,l=Ka(a.type,l),r,n);case 15:return Po(e,t,t.type,t.pendingProps,r,n);case 17:return r=t.type,a=t.pendingProps,a=t.elementType===r?a:Ka(r,a),null!==e&&(e.alternate=null,t.alternate=null,t.flags|=2),t.tag=1,pa(r)?(e=!0,ma(t)):e=!1,tl(t,n),hl(t,r,a),ml(t,r,a,n),Fo(null,t,r,!0,e,n);case 19:return Xo(e,t,n);case 23:case 24:return Uo(e,t,n)}throw Error(o(156,t.tag))},Xu.prototype.render=function(e){Gu(e,this._internalRoot,null,null)},Xu.prototype.unmount=function(){var e=this._internalRoot,t=e.containerInfo;Gu(null,e,null,(function(){t[qr]=null}))},et=function(e){13===e.tag&&(uu(e,4,ou()),Zu(e,4))},tt=function(e){13===e.tag&&(uu(e,67108864,ou()),Zu(e,67108864))},nt=function(e){if(13===e.tag){var t=ou(),n=iu(e);uu(e,n,t),Zu(e,n)}},rt=function(e,t){return t()},xe=function(e,t,n){switch(t){case"input":if(ne(e,n),t=n.name,"radio"===n.type&&null!=t){for(n=e;n.parentNode;)n=n.parentNode;for(n=n.querySelectorAll("input[name="+JSON.stringify(""+t)+'][type="radio"]'),t=0;t<n.length;t++){var r=n[t];if(r!==e&&r.form===e.form){var a=ta(r);if(!a)throw Error(o(90));Z(r),ne(r,a)}}}break;case"textarea":se(e,n);break;case"select":null!=(t=n.value)&&oe(e,!!n.multiple,t,!1)}},De=yu,Oe=function(e,t,n,r,a){var l=xi;xi|=4;try{return Fa(98,e.bind(null,t,n,r,a))}finally{0===(xi=l)&&(Ri(),Ba())}},ze=function(){0==(49&xi)&&(function(){if(null!==Xi){var e=Xi;Xi=null,e.forEach((function(e){e.expiredLanes|=24&e.pendingLanes,cu(e,Ya())}))}Ba()}(),Tu())},Ae=function(e,t){var n=xi;xi|=2;try{return e(t)}finally{0===(xi=n)&&(Ri(),Ba())}};var ns={Events:[Jr,ea,ta,Ce,Ie,Tu,{current:!1}]},rs={findFiberByHostInstance:Xr,bundleType:0,version:"17.0.2",rendererPackageName:"react-dom"},as={bundleType:rs.bundleType,version:rs.version,rendererPackageName:rs.rendererPackageName,rendererConfig:rs.rendererConfig,overrideHookState:null,overrideHookStateDeletePath:null,overrideHookStateRenamePath:null,overrideProps:null,overridePropsDeletePath:null,overridePropsRenamePath:null,setSuspenseHandler:null,scheduleUpdate:null,currentDispatcherRef:E.ReactCurrentDispatcher,findHostInstanceByFiber:function(e){return null===(e=Xe(e))?null:e.stateNode},findFiberByHostInstance:rs.findFiberByHostInstance||function(){return null},findHostInstancesForRefresh:null,scheduleRefresh:null,scheduleRoot:null,setRefreshHandler:null,getCurrentFiber:null};if("undefined"!=typeof __REACT_DEVTOOLS_GLOBAL_HOOK__){var ls=__REACT_DEVTOOLS_GLOBAL_HOOK__;if(!ls.isDisabled&&ls.supportsFiber)try{ba=ls.inject(as),Ma=ls}catch(he){}}t.__SECRET_INTERNALS_DO_NOT_USE_OR_YOU_WILL_BE_FIRED=ns,t.createPortal=ts,t.findDOMNode=function(e){if(null==e)return null;if(1===e.nodeType)return e;var t=e._reactInternals;if(void 0===t){if("function"==typeof e.render)throw Error(o(188));throw Error(o(268,Object.keys(e)))}return null===(e=Xe(t))?null:e.stateNode},t.flushSync=function(e,t){var n=xi;if(0!=(48&n))return e(t);xi|=1;try{if(e)return Fa(99,e.bind(null,t))}finally{xi=n,Ba()}},t.hydrate=function(e,t,n){if(!Ju(t))throw Error(o(200));return es(null,e,t,!0,n)},t.render=function(e,t,n){if(!Ju(t))throw Error(o(200));return es(null,e,t,!1,n)},t.unmountComponentAtNode=function(e){if(!Ju(e))throw Error(o(40));return!!e._reactRootContainer&&(hu((function(){es(null,null,e,!1,(function(){e._reactRootContainer=null,e[qr]=null}))})),!0)},t.unstable_batchedUpdates=yu,t.unstable_createPortal=function(e,t){return ts(e,t,2<arguments.length&&void 0!==arguments[2]?arguments[2]:null)},t.unstable_renderSubtreeIntoContainer=function(e,t,n,r){if(!Ju(n))throw Error(o(200));if(null==e||void 0===e._reactInternals)throw Error(o(38));return es(e,t,n,!1,r)},t.version="17.0.2"},935:(e,t,n)=>{"use strict";!function e(){if("undefined"!=typeof __REACT_DEVTOOLS_GLOBAL_HOOK__&&"function"==typeof __REACT_DEVTOOLS_GLOBAL_HOOK__.checkDCE)try{__REACT_DEVTOOLS_GLOBAL_HOOK__.checkDCE(e)}catch(e){console.error(e)}}(),e.exports=n(448)},357:(e,t,n)=>{"use strict";function r(){return(r=Object.assign||function(e){for(var t=1;t<arguments.length;t++){var n=arguments[t];for(var r in n)Object.prototype.hasOwnProperty.call(n,r)&&(e[r]=n[r])}return e}).apply(this,arguments)}function a(e,t){if(null==e)return{};var n,r,a={},l=Object.keys(e);for(r=0;r<l.length;r++)n=l[r],t.indexOf(n)>=0||(a[n]=e[n]);return a}function l(e,t){return(l=Object.setPrototypeOf||function(e,t){return e.__proto__=t,e})(e,t)}function o(e,t){e.prototype=Object.create(t.prototype),e.prototype.constructor=e,l(e,t)}function i(e,t){return e.replace(new RegExp("(^|\\s)"+t+"(?:\\s|$)","g"),"$1").replace(/\s+/g," ").replace(/^\s*|\s*$/g,"")}n.r(t),n.d(t,{CSSTransition:()=>N,ReplaceTransition:()=>I,SwitchTransition:()=>Q,Transition:()=>M,TransitionGroup:()=>T,config:()=>c});var u=n(294),s=n(935);const c={disabled:!1},f=u.createContext(null);var d=function(e){return e.scrollTop},p="unmounted",y="exited",h="entering",g="entered",m="exiting",v=function(e){function t(t,n){var r;r=e.call(this,t,n)||this;var a,l=n&&!n.isMounting?t.enter:t.appear;return r.appearStatus=null,t.in?l?(a=y,r.appearStatus=h):a=g:a=t.unmountOnExit||t.mountOnEnter?p:y,r.state={status:a},r.nextCallback=null,r}o(t,e),t.getDerivedStateFromProps=function(e,t){return e.in&&t.status===p?{status:y}:null};var n=t.prototype;return n.componentDidMount=function(){this.updateStatus(!0,this.appearStatus)},n.componentDidUpdate=function(e){var t=null;if(e!==this.props){var n=this.state.status;this.props.in?n!==h&&n!==g&&(t=h):n!==h&&n!==g||(t=m)}this.updateStatus(!1,t)},n.componentWillUnmount=function(){this.cancelNextCallback()},n.getTimeouts=function(){var e,t,n,r=this.props.timeout;return e=t=n=r,null!=r&&"number"!=typeof r&&(e=r.exit,t=r.enter,n=void 0!==r.appear?r.appear:t),{exit:e,enter:t,appear:n}},n.updateStatus=function(e,t){if(void 0===e&&(e=!1),null!==t)if(this.cancelNextCallback(),t===h){if(this.props.unmountOnExit||this.props.mountOnEnter){var n=this.props.nodeRef?this.props.nodeRef.current:s.findDOMNode(this);n&&d(n)}this.performEnter(e)}else this.performExit();else this.props.unmountOnExit&&this.state.status===y&&this.setState({status:p})},n.performEnter=function(e){var t=this,n=this.props.enter,r=this.context?this.context.isMounting:e,a=this.props.nodeRef?[r]:[s.findDOMNode(this),r],l=a[0],o=a[1],i=this.getTimeouts(),u=r?i.appear:i.enter;!e&&!n||c.disabled?this.safeSetState({status:g},(function(){t.props.onEntered(l)})):(this.props.onEnter(l,o),this.safeSetState({status:h},(function(){t.props.onEntering(l,o),t.onTransitionEnd(u,(function(){t.safeSetState({status:g},(function(){t.props.onEntered(l,o)}))}))})))},n.performExit=function(){var e=this,t=this.props.exit,n=this.getTimeouts(),r=this.props.nodeRef?void 0:s.findDOMNode(this);t&&!c.disabled?(this.props.onExit(r),this.safeSetState({status:m},(function(){e.props.onExiting(r),e.onTransitionEnd(n.exit,(function(){e.safeSetState({status:y},(function(){e.props.onExited(r)}))}))}))):this.safeSetState({status:y},(function(){e.props.onExited(r)}))},n.cancelNextCallback=function(){null!==this.nextCallback&&(this.nextCallback.cancel(),this.nextCallback=null)},n.safeSetState=function(e,t){t=this.setNextCallback(t),this.setState(e,t)},n.setNextCallback=function(e){var t=this,n=!0;return this.nextCallback=function(r){n&&(n=!1,t.nextCallback=null,e(r))},this.nextCallback.cancel=function(){n=!1},this.nextCallback},n.onTransitionEnd=function(e,t){this.setNextCallback(t);var n=this.props.nodeRef?this.props.nodeRef.current:s.findDOMNode(this),r=null==e&&!this.props.addEndListener;if(n&&!r){if(this.props.addEndListener){var a=this.props.nodeRef?[this.nextCallback]:[n,this.nextCallback],l=a[0],o=a[1];this.props.addEndListener(l,o)}null!=e&&setTimeout(this.nextCallback,e)}else setTimeout(this.nextCallback,0)},n.render=function(){var e=this.state.status;if(e===p)return null;var t=this.props,n=t.children,r=(t.in,t.mountOnEnter,t.unmountOnExit,t.appear,t.enter,t.exit,t.timeout,t.addEndListener,t.onEnter,t.onEntering,t.onEntered,t.onExit,t.onExiting,t.onExited,t.nodeRef,a(t,["children","in","mountOnEnter","unmountOnExit","appear","enter","exit","timeout","addEndListener","onEnter","onEntering","onEntered","onExit","onExiting","onExited","nodeRef"]));return u.createElement(f.Provider,{value:null},"function"==typeof n?n(e,r):u.cloneElement(u.Children.only(n),r))},t}(u.Component);function b(){}v.contextType=f,v.propTypes={},v.defaultProps={in:!1,mountOnEnter:!1,unmountOnExit:!1,appear:!1,enter:!0,exit:!0,onEnter:b,onEntering:b,onEntered:b,onExit:b,onExiting:b,onExited:b},v.UNMOUNTED=p,v.EXITED=y,v.ENTERING=h,v.ENTERED=g,v.EXITING=m;const M=v;var E=function(e,t){return e&&t&&t.split(" ").forEach((function(t){return r=t,void((n=e).classList?n.classList.remove(r):"string"==typeof n.className?n.className=i(n.className,r):n.setAttribute("class",i(n.className&&n.className.baseVal||"",r)));var n,r}))},L=function(e){function t(){for(var t,n=arguments.length,r=new Array(n),a=0;a<n;a++)r[a]=arguments[a];return(t=e.call.apply(e,[this].concat(r))||this).appliedClasses={appear:{},enter:{},exit:{}},t.onEnter=function(e,n){var r=t.resolveArguments(e,n),a=r[0],l=r[1];t.removeClasses(a,"exit"),t.addClass(a,l?"appear":"enter","base"),t.props.onEnter&&t.props.onEnter(e,n)},t.onEntering=function(e,n){var r=t.resolveArguments(e,n),a=r[0],l=r[1]?"appear":"enter";t.addClass(a,l,"active"),t.props.onEntering&&t.props.onEntering(e,n)},t.onEntered=function(e,n){var r=t.resolveArguments(e,n),a=r[0],l=r[1]?"appear":"enter";t.removeClasses(a,l),t.addClass(a,l,"done"),t.props.onEntered&&t.props.onEntered(e,n)},t.onExit=function(e){var n=t.resolveArguments(e)[0];t.removeClasses(n,"appear"),t.removeClasses(n,"enter"),t.addClass(n,"exit","base"),t.props.onExit&&t.props.onExit(e)},t.onExiting=function(e){var n=t.resolveArguments(e)[0];t.addClass(n,"exit","active"),t.props.onExiting&&t.props.onExiting(e)},t.onExited=function(e){var n=t.resolveArguments(e)[0];t.removeClasses(n,"exit"),t.addClass(n,"exit","done"),t.props.onExited&&t.props.onExited(e)},t.resolveArguments=function(e,n){return t.props.nodeRef?[t.props.nodeRef.current,e]:[e,n]},t.getClassNames=function(e){var n=t.props.classNames,r="string"==typeof n,a=r?(r&&n?n+"-":"")+e:n[e];return{baseClassName:a,activeClassName:r?a+"-active":n[e+"Active"],doneClassName:r?a+"-done":n[e+"Done"]}},t}o(t,e);var n=t.prototype;return n.addClass=function(e,t,n){var r=this.getClassNames(t)[n+"ClassName"],a=this.getClassNames("enter").doneClassName;"appear"===t&&"done"===n&&a&&(r+=" "+a),"active"===n&&e&&d(e),r&&(this.appliedClasses[t][n]=r,function(e,t){e&&t&&t.split(" ").forEach((function(t){return r=t,void((n=e).classList?n.classList.add(r):function(e,t){return e.classList?!!t&&e.classList.contains(t):-1!==(" "+(e.className.baseVal||e.className)+" ").indexOf(" "+t+" ")}(n,r)||("string"==typeof n.className?n.className=n.className+" "+r:n.setAttribute("class",(n.className&&n.className.baseVal||"")+" "+r)));var n,r}))}(e,r))},n.removeClasses=function(e,t){var n=this.appliedClasses[t],r=n.base,a=n.active,l=n.done;this.appliedClasses[t]={},r&&E(e,r),a&&E(e,a),l&&E(e,l)},n.render=function(){var e=this.props,t=(e.classNames,a(e,["classNames"]));return u.createElement(M,r({},t,{onEnter:this.onEnter,onEntered:this.onEntered,onEntering:this.onEntering,onExit:this.onExit,onExiting:this.onExiting,onExited:this.onExited}))},t}(u.Component);L.defaultProps={classNames:""},L.propTypes={};const N=L;function w(e,t){var n=Object.create(null);return e&&u.Children.map(e,(function(e){return e})).forEach((function(e){n[e.key]=function(e){return t&&(0,u.isValidElement)(e)?t(e):e}(e)})),n}function S(e,t,n){return null!=n[t]?n[t]:e.props[t]}function x(e,t,n){var r=w(e.children),a=function(e,t){function n(n){return n in t?t[n]:e[n]}e=e||{},t=t||{};var r,a=Object.create(null),l=[];for(var o in e)o in t?l.length&&(a[o]=l,l=[]):l.push(o);var i={};for(var u in t){if(a[u])for(r=0;r<a[u].length;r++){var s=a[u][r];i[a[u][r]]=n(s)}i[u]=n(u)}for(r=0;r<l.length;r++)i[l[r]]=n(l[r]);return i}(t,r);return Object.keys(a).forEach((function(l){var o=a[l];if((0,u.isValidElement)(o)){var i=l in t,s=l in r,c=t[l],f=(0,u.isValidElement)(c)&&!c.props.in;!s||i&&!f?s||!i||f?s&&i&&(0,u.isValidElement)(c)&&(a[l]=(0,u.cloneElement)(o,{onExited:n.bind(null,o),in:c.props.in,exit:S(o,"exit",e),enter:S(o,"enter",e)})):a[l]=(0,u.cloneElement)(o,{in:!1}):a[l]=(0,u.cloneElement)(o,{onExited:n.bind(null,o),in:!0,exit:S(o,"exit",e),enter:S(o,"enter",e)})}})),a}var k=Object.values||function(e){return Object.keys(e).map((function(t){return e[t]}))},j=function(e){function t(t,n){var r,a=(r=e.call(this,t,n)||this).handleExited.bind(function(e){if(void 0===e)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return e}(r));return r.state={contextValue:{isMounting:!0},handleExited:a,firstRender:!0},r}o(t,e);var n=t.prototype;return n.componentDidMount=function(){this.mounted=!0,this.setState({contextValue:{isMounting:!1}})},n.componentWillUnmount=function(){this.mounted=!1},t.getDerivedStateFromProps=function(e,t){var n,r,a=t.children,l=t.handleExited;return{children:t.firstRender?(n=e,r=l,w(n.children,(function(e){return(0,u.cloneElement)(e,{onExited:r.bind(null,e),in:!0,appear:S(e,"appear",n),enter:S(e,"enter",n),exit:S(e,"exit",n)})}))):x(e,a,l),firstRender:!1}},n.handleExited=function(e,t){var n=w(this.props.children);e.key in n||(e.props.onExited&&e.props.onExited(t),this.mounted&&this.setState((function(t){var n=r({},t.children);return delete n[e.key],{children:n}})))},n.render=function(){var e=this.props,t=e.component,n=e.childFactory,r=a(e,["component","childFactory"]),l=this.state.contextValue,o=k(this.state.children).map(n);return delete r.appear,delete r.enter,delete r.exit,null===t?u.createElement(f.Provider,{value:l},o):u.createElement(f.Provider,{value:l},u.createElement(t,r,o))},t}(u.Component);j.propTypes={},j.defaultProps={component:"div",childFactory:function(e){return e}};const T=j;var C=function(e){function t(){for(var t,n=arguments.length,r=new Array(n),a=0;a<n;a++)r[a]=arguments[a];return(t=e.call.apply(e,[this].concat(r))||this).handleEnter=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onEnter",0,n)},t.handleEntering=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onEntering",0,n)},t.handleEntered=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onEntered",0,n)},t.handleExit=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onExit",1,n)},t.handleExiting=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onExiting",1,n)},t.handleExited=function(){for(var e=arguments.length,n=new Array(e),r=0;r<e;r++)n[r]=arguments[r];return t.handleLifecycle("onExited",1,n)},t}o(t,e);var n=t.prototype;return n.handleLifecycle=function(e,t,n){var r,a=this.props.children,l=u.Children.toArray(a)[t];if(l.props[e]&&(r=l.props)[e].apply(r,n),this.props[e]){var o=l.props.nodeRef?void 0:s.findDOMNode(this);this.props[e](o)}},n.render=function(){var e=this.props,t=e.children,n=e.in,r=a(e,["children","in"]),l=u.Children.toArray(t),o=l[0],i=l[1];return delete r.onEnter,delete r.onEntering,delete r.onEntered,delete r.onExit,delete r.onExiting,delete r.onExited,u.createElement(T,r,n?u.cloneElement(o,{key:"first",onEnter:this.handleEnter,onEntering:this.handleEntering,onEntered:this.handleEntered}):u.cloneElement(i,{key:"second",onEnter:this.handleExit,onEntering:this.handleExiting,onEntered:this.handleExited}))},t}(u.Component);C.propTypes={};const I=C;var D,O,z="out-in",A="in-out",_=function(e,t,n){return function(){var r;e.props[t]&&(r=e.props)[t].apply(r,arguments),n()}},P=((D={})["out-in"]=function(e){var t=e.current,n=e.changeState;return u.cloneElement(t,{in:!1,onExited:_(t,"onExited",(function(){n(h,null)}))})},D[A]=function(e){var t=e.current,n=e.changeState,r=e.children;return[t,u.cloneElement(r,{in:!0,onEntered:_(r,"onEntered",(function(){n(h)}))})]},D),U=((O={})["out-in"]=function(e){var t=e.children,n=e.changeState;return u.cloneElement(t,{in:!0,onEntered:_(t,"onEntered",(function(){n(g,u.cloneElement(t,{in:!0}))}))})},O[A]=function(e){var t=e.current,n=e.children,r=e.changeState;return[u.cloneElement(t,{in:!1,onExited:_(t,"onExited",(function(){r(g,u.cloneElement(n,{in:!0}))}))}),u.cloneElement(n,{in:!0})]},O),Y=function(e){function t(){for(var t,n=arguments.length,r=new Array(n),a=0;a<n;a++)r[a]=arguments[a];return(t=e.call.apply(e,[this].concat(r))||this).state={status:g,current:null},t.appeared=!1,t.changeState=function(e,n){void 0===n&&(n=t.state.current),t.setState({status:e,current:n})},t}o(t,e);var n=t.prototype;return n.componentDidMount=function(){this.appeared=!0},t.getDerivedStateFromProps=function(e,t){return null==e.children?{current:null}:t.status===h&&e.mode===A?{status:h}:!t.current||((n=t.current)===(r=e.children)||u.isValidElement(n)&&u.isValidElement(r)&&null!=n.key&&n.key===r.key)?{current:u.cloneElement(e.children,{in:!0})}:{status:m};var n,r},n.render=function(){var e,t=this.props,n=t.children,r=t.mode,a=this.state,l=a.status,o=a.current,i={children:n,current:o,changeState:this.changeState,status:l};switch(l){case h:e=U[r](i);break;case m:e=P[r](i);break;case g:e=o}return u.createElement(f.Provider,{value:{isMounting:!this.appeared}},e)},t}(u.Component);Y.propTypes={},Y.defaultProps={mode:z};const Q=Y},408:(e,t,n)=>{"use strict";var r=n(418),a=60103,l=60106;t.Fragment=60107,t.StrictMode=60108,t.Profiler=60114;var o=60109,i=60110,u=60112;t.Suspense=60113;var s=60115,c=60116;if("function"==typeof Symbol&&Symbol.for){var f=Symbol.for;a=f("react.element"),l=f("react.portal"),t.Fragment=f("react.fragment"),t.StrictMode=f("react.strict_mode"),t.Profiler=f("react.profiler"),o=f("react.provider"),i=f("react.context"),u=f("react.forward_ref"),t.Suspense=f("react.suspense"),s=f("react.memo"),c=f("react.lazy")}var d="function"==typeof Symbol&&Symbol.iterator;function p(e){for(var t="https://reactjs.org/docs/error-decoder.html?invariant="+e,n=1;n<arguments.length;n++)t+="&args[]="+encodeURIComponent(arguments[n]);return"Minified React error #"+e+"; visit "+t+" for the full message or use the non-minified dev environment for full errors and additional helpful warnings."}var y={isMounted:function(){return!1},enqueueForceUpdate:function(){},enqueueReplaceState:function(){},enqueueSetState:function(){}},h={};function g(e,t,n){this.props=e,this.context=t,this.refs=h,this.updater=n||y}function m(){}function v(e,t,n){this.props=e,this.context=t,this.refs=h,this.updater=n||y}g.prototype.isReactComponent={},g.prototype.setState=function(e,t){if("object"!=typeof e&&"function"!=typeof e&&null!=e)throw Error(p(85));this.updater.enqueueSetState(this,e,t,"setState")},g.prototype.forceUpdate=function(e){this.updater.enqueueForceUpdate(this,e,"forceUpdate")},m.prototype=g.prototype;var b=v.prototype=new m;b.constructor=v,r(b,g.prototype),b.isPureReactComponent=!0;var M={current:null},E=Object.prototype.hasOwnProperty,L={key:!0,ref:!0,__self:!0,__source:!0};function N(e,t,n){var r,l={},o=null,i=null;if(null!=t)for(r in void 0!==t.ref&&(i=t.ref),void 0!==t.key&&(o=""+t.key),t)E.call(t,r)&&!L.hasOwnProperty(r)&&(l[r]=t[r]);var u=arguments.length-2;if(1===u)l.children=n;else if(1<u){for(var s=Array(u),c=0;c<u;c++)s[c]=arguments[c+2];l.children=s}if(e&&e.defaultProps)for(r in u=e.defaultProps)void 0===l[r]&&(l[r]=u[r]);return{$$typeof:a,type:e,key:o,ref:i,props:l,_owner:M.current}}function w(e){return"object"==typeof e&&null!==e&&e.$$typeof===a}var S=/\/+/g;function x(e,t){return"object"==typeof e&&null!==e&&null!=e.key?function(e){var t={"=":"=0",":":"=2"};return"$"+e.replace(/[=:]/g,(function(e){return t[e]}))}(""+e.key):t.toString(36)}function k(e,t,n,r,o){var i=typeof e;"undefined"!==i&&"boolean"!==i||(e=null);var u=!1;if(null===e)u=!0;else switch(i){case"string":case"number":u=!0;break;case"object":switch(e.$$typeof){case a:case l:u=!0}}if(u)return o=o(u=e),e=""===r?"."+x(u,0):r,Array.isArray(o)?(n="",null!=e&&(n=e.replace(S,"$&/")+"/"),k(o,t,n,"",(function(e){return e}))):null!=o&&(w(o)&&(o=function(e,t){return{$$typeof:a,type:e.type,key:t,ref:e.ref,props:e.props,_owner:e._owner}}(o,n+(!o.key||u&&u.key===o.key?"":(""+o.key).replace(S,"$&/")+"/")+e)),t.push(o)),1;if(u=0,r=""===r?".":r+":",Array.isArray(e))for(var s=0;s<e.length;s++){var c=r+x(i=e[s],s);u+=k(i,t,n,c,o)}else if("function"==typeof(c=function(e){return null===e||"object"!=typeof e?null:"function"==typeof(e=d&&e[d]||e["@iterator"])?e:null}(e)))for(e=c.call(e),s=0;!(i=e.next()).done;)u+=k(i=i.value,t,n,c=r+x(i,s++),o);else if("object"===i)throw t=""+e,Error(p(31,"[object Object]"===t?"object with keys {"+Object.keys(e).join(", ")+"}":t));return u}function j(e,t,n){if(null==e)return e;var r=[],a=0;return k(e,r,"","",(function(e){return t.call(n,e,a++)})),r}function T(e){if(-1===e._status){var t=e._result;t=t(),e._status=0,e._result=t,t.then((function(t){0===e._status&&(t=t.default,e._status=1,e._result=t)}),(function(t){0===e._status&&(e._status=2,e._result=t)}))}if(1===e._status)return e._result;throw e._result}var C={current:null};function I(){var e=C.current;if(null===e)throw Error(p(321));return e}var D={ReactCurrentDispatcher:C,ReactCurrentBatchConfig:{transition:0},ReactCurrentOwner:M,IsSomeRendererActing:{current:!1},assign:r};t.Children={map:j,forEach:function(e,t,n){j(e,(function(){t.apply(this,arguments)}),n)},count:function(e){var t=0;return j(e,(function(){t++})),t},toArray:function(e){return j(e,(function(e){return e}))||[]},only:function(e){if(!w(e))throw Error(p(143));return e}},t.Component=g,t.PureComponent=v,t.__SECRET_INTERNALS_DO_NOT_USE_OR_YOU_WILL_BE_FIRED=D,t.cloneElement=function(e,t,n){if(null==e)throw Error(p(267,e));var l=r({},e.props),o=e.key,i=e.ref,u=e._owner;if(null!=t){if(void 0!==t.ref&&(i=t.ref,u=M.current),void 0!==t.key&&(o=""+t.key),e.type&&e.type.defaultProps)var s=e.type.defaultProps;for(c in t)E.call(t,c)&&!L.hasOwnProperty(c)&&(l[c]=void 0===t[c]&&void 0!==s?s[c]:t[c])}var c=arguments.length-2;if(1===c)l.children=n;else if(1<c){s=Array(c);for(var f=0;f<c;f++)s[f]=arguments[f+2];l.children=s}return{$$typeof:a,type:e.type,key:o,ref:i,props:l,_owner:u}},t.createContext=function(e,t){return void 0===t&&(t=null),(e={$$typeof:i,_calculateChangedBits:t,_currentValue:e,_currentValue2:e,_threadCount:0,Provider:null,Consumer:null}).Provider={$$typeof:o,_context:e},e.Consumer=e},t.createElement=N,t.createFactory=function(e){var t=N.bind(null,e);return t.type=e,t},t.createRef=function(){return{current:null}},t.forwardRef=function(e){return{$$typeof:u,render:e}},t.isValidElement=w,t.lazy=function(e){return{$$typeof:c,_payload:{_status:-1,_result:e},_init:T}},t.memo=function(e,t){return{$$typeof:s,type:e,compare:void 0===t?null:t}},t.useCallback=function(e,t){return I().useCallback(e,t)},t.useContext=function(e,t){return I().useContext(e,t)},t.useDebugValue=function(){},t.useEffect=function(e,t){return I().useEffect(e,t)},t.useImperativeHandle=function(e,t,n){return I().useImperativeHandle(e,t,n)},t.useLayoutEffect=function(e,t){return I().useLayoutEffect(e,t)},t.useMemo=function(e,t){return I().useMemo(e,t)},t.useReducer=function(e,t,n){return I().useReducer(e,t,n)},t.useRef=function(e){return I().useRef(e)},t.useState=function(e){return I().useState(e)},t.version="17.0.2"},294:(e,t,n)=>{"use strict";e.exports=n(408)},53:(e,t)=>{"use strict";var n,r,a,l;if("object"==typeof performance&&"function"==typeof performance.now){var o=performance;t.unstable_now=function(){return o.now()}}else{var i=Date,u=i.now();t.unstable_now=function(){return i.now()-u}}if("undefined"==typeof window||"function"!=typeof MessageChannel){var s=null,c=null,f=function(){if(null!==s)try{var e=t.unstable_now();s(!0,e),s=null}catch(e){throw setTimeout(f,0),e}};n=function(e){null!==s?setTimeout(n,0,e):(s=e,setTimeout(f,0))},r=function(e,t){c=setTimeout(e,t)},a=function(){clearTimeout(c)},t.unstable_shouldYield=function(){return!1},l=t.unstable_forceFrameRate=function(){}}else{var d=window.setTimeout,p=window.clearTimeout;if("undefined"!=typeof console){var y=window.cancelAnimationFrame;"function"!=typeof window.requestAnimationFrame&&console.error("This browser doesn't support requestAnimationFrame. Make sure that you load a polyfill in older browsers. https://reactjs.org/link/react-polyfills"),"function"!=typeof y&&console.error("This browser doesn't support cancelAnimationFrame. Make sure that you load a polyfill in older browsers. https://reactjs.org/link/react-polyfills")}var h=!1,g=null,m=-1,v=5,b=0;t.unstable_shouldYield=function(){return t.unstable_now()>=b},l=function(){},t.unstable_forceFrameRate=function(e){0>e||125<e?console.error("forceFrameRate takes a positive int between 0 and 125, forcing frame rates higher than 125 fps is not supported"):v=0<e?Math.floor(1e3/e):5};var M=new MessageChannel,E=M.port2;M.port1.onmessage=function(){if(null!==g){var e=t.unstable_now();b=e+v;try{g(!0,e)?E.postMessage(null):(h=!1,g=null)}catch(e){throw E.postMessage(null),e}}else h=!1},n=function(e){g=e,h||(h=!0,E.postMessage(null))},r=function(e,n){m=d((function(){e(t.unstable_now())}),n)},a=function(){p(m),m=-1}}function L(e,t){var n=e.length;e.push(t);e:for(;;){var r=n-1>>>1,a=e[r];if(!(void 0!==a&&0<S(a,t)))break e;e[r]=t,e[n]=a,n=r}}function N(e){return void 0===(e=e[0])?null:e}function w(e){var t=e[0];if(void 0!==t){var n=e.pop();if(n!==t){e[0]=n;e:for(var r=0,a=e.length;r<a;){var l=2*(r+1)-1,o=e[l],i=l+1,u=e[i];if(void 0!==o&&0>S(o,n))void 0!==u&&0>S(u,o)?(e[r]=u,e[i]=n,r=i):(e[r]=o,e[l]=n,r=l);else{if(!(void 0!==u&&0>S(u,n)))break e;e[r]=u,e[i]=n,r=i}}}return t}return null}function S(e,t){var n=e.sortIndex-t.sortIndex;return 0!==n?n:e.id-t.id}var x=[],k=[],j=1,T=null,C=3,I=!1,D=!1,O=!1;function z(e){for(var t=N(k);null!==t;){if(null===t.callback)w(k);else{if(!(t.startTime<=e))break;w(k),t.sortIndex=t.expirationTime,L(x,t)}t=N(k)}}function A(e){if(O=!1,z(e),!D)if(null!==N(x))D=!0,n(_);else{var t=N(k);null!==t&&r(A,t.startTime-e)}}function _(e,n){D=!1,O&&(O=!1,a()),I=!0;var l=C;try{for(z(n),T=N(x);null!==T&&(!(T.expirationTime>n)||e&&!t.unstable_shouldYield());){var o=T.callback;if("function"==typeof o){T.callback=null,C=T.priorityLevel;var i=o(T.expirationTime<=n);n=t.unstable_now(),"function"==typeof i?T.callback=i:T===N(x)&&w(x),z(n)}else w(x);T=N(x)}if(null!==T)var u=!0;else{var s=N(k);null!==s&&r(A,s.startTime-n),u=!1}return u}finally{T=null,C=l,I=!1}}var P=l;t.unstable_IdlePriority=5,t.unstable_ImmediatePriority=1,t.unstable_LowPriority=4,t.unstable_NormalPriority=3,t.unstable_Profiling=null,t.unstable_UserBlockingPriority=2,t.unstable_cancelCallback=function(e){e.callback=null},t.unstable_continueExecution=function(){D||I||(D=!0,n(_))},t.unstable_getCurrentPriorityLevel=function(){return C},t.unstable_getFirstCallbackNode=function(){return N(x)},t.unstable_next=function(e){switch(C){case 1:case 2:case 3:var t=3;break;default:t=C}var n=C;C=t;try{return e()}finally{C=n}},t.unstable_pauseExecution=function(){},t.unstable_requestPaint=P,t.unstable_runWithPriority=function(e,t){switch(e){case 1:case 2:case 3:case 4:case 5:break;default:e=3}var n=C;C=e;try{return t()}finally{C=n}},t.unstable_scheduleCallback=function(e,l,o){var i=t.unstable_now();switch(o="object"==typeof o&&null!==o&&"number"==typeof(o=o.delay)&&0<o?i+o:i,e){case 1:var u=-1;break;case 2:u=250;break;case 5:u=1073741823;break;case 4:u=1e4;break;default:u=5e3}return e={id:j++,callback:l,priorityLevel:e,startTime:o,expirationTime:u=o+u,sortIndex:-1},o>i?(e.sortIndex=o,L(k,e),null===N(x)&&e===N(k)&&(O?a():O=!0,r(A,o-i))):(e.sortIndex=u,L(x,e),D||I||(D=!0,n(_))),e},t.unstable_wrapCallback=function(e){var t=C;return function(){var n=C;C=t;try{return e.apply(this,arguments)}finally{C=n}}}},840:(e,t,n)=>{"use strict";e.exports=n(53)},188:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(151);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},413:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(148);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},810:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(908);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},454:(e,t,n)=>{"use strict";n.r(t),n.d(t,{default:()=>o});var r=n(379),a=n.n(r),l=n(174);a()(l.Z,{insert:"head",singleton:!1});const o=l.Z.locals||{}},379:(e,t,n)=>{"use strict";var r,a=function(){var e={};return function(t){if(void 0===e[t]){var n=document.querySelector(t);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(e){n=null}e[t]=n}return e[t]}}(),l=[];function o(e){for(var t=-1,n=0;n<l.length;n++)if(l[n].identifier===e){t=n;break}return t}function i(e,t){for(var n={},r=[],a=0;a<e.length;a++){var i=e[a],u=t.base?i[0]+t.base:i[0],s=n[u]||0,c="".concat(u," ").concat(s);n[u]=s+1;var f=o(c),d={css:i[1],media:i[2],sourceMap:i[3]};-1!==f?(l[f].references++,l[f].updater(d)):l.push({identifier:c,updater:h(d,t),references:1}),r.push(c)}return r}function u(e){var t=document.createElement("style"),r=e.attributes||{};if(void 0===r.nonce){var l=n.nc;l&&(r.nonce=l)}if(Object.keys(r).forEach((function(e){t.setAttribute(e,r[e])})),"function"==typeof e.insert)e.insert(t);else{var o=a(e.insert||"head");if(!o)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");o.appendChild(t)}return t}var s,c=(s=[],function(e,t){return s[e]=t,s.filter(Boolean).join("\n")});function f(e,t,n,r){var a=n?"":r.media?"@media ".concat(r.media," {").concat(r.css,"}"):r.css;if(e.styleSheet)e.styleSheet.cssText=c(t,a);else{var l=document.createTextNode(a),o=e.childNodes;o[t]&&e.removeChild(o[t]),o.length?e.insertBefore(l,o[t]):e.appendChild(l)}}function d(e,t,n){var r=n.css,a=n.media,l=n.sourceMap;if(a?e.setAttribute("media",a):e.removeAttribute("media"),l&&"undefined"!=typeof btoa&&(r+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(l))))," */")),e.styleSheet)e.styleSheet.cssText=r;else{for(;e.firstChild;)e.removeChild(e.firstChild);e.appendChild(document.createTextNode(r))}}var p=null,y=0;function h(e,t){var n,r,a;if(t.singleton){var l=y++;n=p||(p=u(t)),r=f.bind(null,n,l,!1),a=f.bind(null,n,l,!0)}else n=u(t),r=d.bind(null,n,t),a=function(){!function(e){if(null===e.parentNode)return!1;e.parentNode.removeChild(e)}(n)};return r(e),function(t){if(t){if(t.css===e.css&&t.media===e.media&&t.sourceMap===e.sourceMap)return;r(e=t)}else a()}}e.exports=function(e,t){(t=t||{}).singleton||"boolean"==typeof t.singleton||(t.singleton=(void 0===r&&(r=Boolean(window&&document&&document.all&&!window.atob)),r));var n=i(e=e||[],t);return function(e){if(e=e||[],"[object Array]"===Object.prototype.toString.call(e)){for(var r=0;r<n.length;r++){var a=o(n[r]);l[a].references--}for(var u=i(e,t),s=0;s<n.length;s++){var c=o(n[s]);0===l[c].references&&(l[c].updater(),l.splice(c,1))}n=u}}}}},t={};function n(r){var a=t[r];if(void 0!==a)return a.exports;var l=t[r]={id:r,exports:{}};return e[r](l,l.exports,n),l.exports}n.n=e=>{var t=e&&e.__esModule?()=>e.default:()=>e;return n.d(t,{a:t}),t},n.d=(e,t)=>{for(var r in t)n.o(t,r)&&!n.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},n.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),n.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},(()=>{"use strict";var e=n(294),t=n(935),r=n(490),a={pub:function(e){a.subs[e]||(a.subs[e]=[]),a.subs[e].forEach((function(e){return e()}))},sub:function(e,t){a.subs[e]||(a.subs[e]=[]),a.subs[e].push(t)},subs:{}};$(document).ready((function(){$("body").append($('<div id="cookie-consent"></div>')),t.render(e.createElement(r.Z,{dispatcher:a}),document.getElementById("cookie-consent"))})),window.plosCookieConsentBanner={reopen:function(){a.pub("open")}}})()})(); </script>  <script type="text/javascript" src="https://dnascience.plos.org/wp-content/plugins/plos-elementor-widgets/assets/js/widgets.js?ver=0.0.1" id="plos-elementor-js"></script> <script type="text/javascript" src="https://dnascience.plos.org/wp-content/plugins/plos-elementor-widgets/assets/lib/slick-1.8.1/slick/slick.js?ver=1.8.1" id="slick-js"></script> <script type="text/javascript" src="https://dnascience.plos.org/wp-content/themes/plos/dist/scripts/main_2eafddd7.js?ver=0.0.8" id="sage/main.js-js"></script>  <script> !function(e,t,n,s,u,a){e.twq||(s=e.twq=function(){s.exe?s.exe.apply(s,arguments):s.queue.push(arguments); },s.version='1.1',s.queue=[],u=t.createElement(n),u.async=!0,u.src='//static.ads-twitter.com/uwt.js', a=t.getElementsByTagName(n)[0],a.parentNode.insertBefore(u,a))}(window,document,'script'); twq('init','o5hg7'); twq('track','PageView'); </script>  </body> </html>

CINXE.COM

DNA Science - Geneticist Ricki Lewis blogs from the cutting edge of genomics, including genetic testing, stem cells, gene therapy and more.