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hydrogel</title> <meta name="description" content="Search results for: hydrogel"> <meta name="keywords" content="hydrogel"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="hydrogel"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 161</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: hydrogel</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">161</span> Optimization of Hydrogel Conductive Nanocomposite as Solar Cell</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shimaa%20M.%20Elsaeed">Shimaa M. Elsaeed</a>, <a href="https://publications.waset.org/abstracts/search?q=Reem%20K.%20Farag"> Reem K. Farag</a>, <a href="https://publications.waset.org/abstracts/search?q=Ibrahim%20M.%20Nassar"> Ibrahim M. Nassar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hydrogel conductive polymer nanocomposite fabricated via in-situ polymerization of polyaniline (PANI) inside thermosensitive hydrogels based on hydroxy ethyl meth acrylate (HEMA) copolymer with 2-acrylamido-2-methyl propane sulfonic acid (AMPS). SEM micrographs show the nanometric size of the conductive material (polyaniline, PANI) dispersed in the hydrogel matrix. The swelling parameters of hydrogel are measured. The incorporation of PANI improves the mechanical properties and swelling up to 30,000% without breaking. X-ray diffraction shows that typical polyaniline crystallization is formed in composite, which is advantageous to increase the electrical conductivity of the composite hydrogel. Open-circuit voltage (I-V) curve fill factor of the highest photo-conversion efficiency and enhanced to use in solar cell. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title="hydrogel">hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=solar%20cell" title=" solar cell"> solar cell</a>, <a href="https://publications.waset.org/abstracts/search?q=conductive%20polymer" title=" conductive polymer"> conductive polymer</a>, <a href="https://publications.waset.org/abstracts/search?q=nanocomposite" title=" nanocomposite"> nanocomposite</a> </p> <a href="https://publications.waset.org/abstracts/42489/optimization-of-hydrogel-conductive-nanocomposite-as-solar-cell" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42489.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">399</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">160</span> Functional Slow Release of Encapsulated Ibuprofen in Cross-linked Gellan Gum Hydrogel for Tissue Engineering Application</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nor%20Jannah%20Mohd%20Sebri">Nor Jannah Mohd Sebri</a>, <a href="https://publications.waset.org/abstracts/search?q=Khairul%20Anuar%20Mat%20Amin"> Khairul Anuar Mat Amin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Dication cross-linked gellan gum hydrogel loaded with Ibuprofen with excellent mechanical properties had been synthesized as potential candidate for non-toxic biocompatible polymer material in tissue engineering. The gellan gum hydrogel with 5% Ibuprofen had produced a slow release profile with total drug release time of 25 hours as a resulting low swelling value recorded at 22+0.5%. Its compressive strength, 200.13+21 kPa was highest of all other hydrogel ratio of 0.5% and 1.0% Ibuprofen incorporation. Young’s Modulus of the hydrogel with 5% Ibuprofen was recorded at 1.8+0.01 MPa, indicating good gel strength in which it is capable of withstanding a fair amount of subjected force during topical wound dressing application. Excellent mechanical properties, together with slow release profile, make the ibuprofen-loaded hydrogel a prospect candidate as biocompatible extracellular matrices in wound management. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gellan%20gum" title="gellan gum">gellan gum</a>, <a href="https://publications.waset.org/abstracts/search?q=ibuprofen" title=" ibuprofen"> ibuprofen</a>, <a href="https://publications.waset.org/abstracts/search?q=slow%20drug%20release" title=" slow drug release"> slow drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a> </p> <a href="https://publications.waset.org/abstracts/19329/functional-slow-release-of-encapsulated-ibuprofen-in-cross-linked-gellan-gum-hydrogel-for-tissue-engineering-application" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19329.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">400</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">159</span> Physicochemical Attributes of Pectin Hydrogel and Its Wound Healing Activity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nor%20Khaizan%20Anuar">Nor Khaizan Anuar</a>, <a href="https://publications.waset.org/abstracts/search?q=Nur%20Karimah%20Aziz"> Nur Karimah Aziz</a>, <a href="https://publications.waset.org/abstracts/search?q=Tin%20Wui%20Wong"> Tin Wui Wong</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmad%20Sazali%20Hamzah"> Ahmad Sazali Hamzah</a>, <a href="https://publications.waset.org/abstracts/search?q=Wan%20Rozita%20Wan%20Engah"> Wan Rozita Wan Engah </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The physicochemical attributes and wound healing activity of pectin hydrogel in rat models, following partial thickness thermal injury were investigated. The pectin hydrogel was prepared by solvent evaporation method with the aid of glutaraldehyde as crosslinking agent and glycerol as plasticizer. The physicochemical properties were mainly evaluated using differential scanning calorimetry (DSC) and Fourier transform infrared (FTIR) spectroscopy, while the wound healing activity was examined by the macroscopic images, wound size reduction and histological evaluation using haematoxylin and eosin (H&E) stain for 14 days. The DSC and FTIR analysis suggested that pectin hydrogel exhibited higher extent of polymer-polymer interaction at O-H functional group in comparison to the unprocessed pectin. This was indicated by the increase of endothermic enthalpy values from 139.35 ± 13.06 J/g of unprocessed pectin to 156.23 ± 2.86 J/g of pectin hydrogel, as well as the decrease of FTIR wavenumber corresponding to O-H at 3432.07 ± 0.49 cm-1 of unprocessed pectin to 3412.62 ± 13.06 cm-1 of pectin hydrogel. Rats treated with pectin hydrogel had significantly smaller wound size (Student’s t-test, p<0.05) when compared to the untreated group starting from day 7 until day 14. H&E staining indicated that wounds received pectin hydrogel had more fibroblasts, blood vessels and collagen bundles on day 14 in comparison to the untreated rats. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pectin" title="pectin">pectin</a>, <a href="https://publications.waset.org/abstracts/search?q=physicochemical" title=" physicochemical"> physicochemical</a>, <a href="https://publications.waset.org/abstracts/search?q=rats" title=" rats"> rats</a>, <a href="https://publications.waset.org/abstracts/search?q=wound" title=" wound"> wound</a> </p> <a href="https://publications.waset.org/abstracts/43465/physicochemical-attributes-of-pectin-hydrogel-and-its-wound-healing-activity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/43465.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">360</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">158</span> A Thermosensitive Polypeptide Hydrogel for Biomedical Application</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chih-Chi%20Cheng">Chih-Chi Cheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Ji-Yu%20Lin"> Ji-Yu Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=I-Ming%20Chu"> I-Ming Chu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, we synthesized a thermosensitive polypeptide hydrogel by copolymerizing poloxamer (PLX) and poly(ʟ-alanine) with ʟ-lysine segments at the both ends to form PLX-b-poly(ʟ-alanine-lysine) (Lys-Ala-PLX-Ala-Lys) copolymers. Poly(ʟ-alanine) is the hydrophobic chain of Lys-Ala-PLX-Ala-Lys copolymers which was designed to capture the hydrophobic agents. The synthesis was examined by 1H NMR and showed that Lys-Ala-PLX-Ala-Lys copolymers were successfully synthesized. At the concentration range of 3-7 wt%, the aqueous copolymer solution underwent sol-gel transition near the physiological temperature and exhibited changes in its secondary structure content, as evidenced by FTIR. The excellent viability of cells cultured within the scaffold was observed after 72 hr of incubation. Also, negatively charged bovine serum albumin was incorporated into the hydrogel without diminishing material integrity and shows good release profile. In the animal study, the results also indicated that Lys-Ala-PLX-Ala-Lys hydrogel has high potential in wound dressing. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=polypeptide%20thermosensitive%20hydrogel" title="polypeptide thermosensitive hydrogel">polypeptide thermosensitive hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=tacrolimus" title=" tacrolimus"> tacrolimus</a>, <a href="https://publications.waset.org/abstracts/search?q=vascularized%20composite%20allotransplantation" title=" vascularized composite allotransplantation"> vascularized composite allotransplantation</a>, <a href="https://publications.waset.org/abstracts/search?q=sustain%20release" title=" sustain release"> sustain release</a> </p> <a href="https://publications.waset.org/abstracts/66746/a-thermosensitive-polypeptide-hydrogel-for-biomedical-application" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66746.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">292</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">157</span> Preparation and in vitro Bactericidal and Fungicidal Efficiency of NanoSilver/Methylcellulose Hydrogel</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20Panacek">A. Panacek</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Kilianova"> M. Kilianova</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Prucek"> R. Prucek</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20Husickova"> V. Husickova</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Vecerova"> R. Vecerova</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Kolar"> M. Kolar</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20Kvitek"> L. Kvitek</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Zboril"> R. Zboril</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this work we describe the preparation of NanoSilver/methylcellulose hydrogel containing silver nanoparticles (NPs) for topical bactericidal applications. Highly concentrated dispersion of silver NPs as high as of 5g/L of silver with diameter of 10nm was prepared by reduction of AgNO3 via strong reducing agent NaBH4. Silver NPs were stabilized by addition of sodium polyacrylate in order to prevent their aggregation at such high concentration. This way synthesized silver NPs were subsequently incorporated into methylcellulose suspension at elevated temperature resulting in formation of NanoSilver/methylcellulose hydrogel when temperature cooled down to laboratory conditions. In vitro antibacterial activity assay proved high bactericidal and fungicidal efficiency of silver NPs alone in the form of dispersion as well as in the form of hydrogel against broad spectrum of bacteria and yeasts including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus. A very low concentrations of silver as low as 0.84mg/L Ag in as-prepared dispersion gave antibacterial performance. NanoSilver/methylcellulose hydrogel showed antibacterial action at the lowest used silver concentration equal to 25mg/L. Such prepared NanoSilver/methylcellulose hydrogel represent promising topical antimicrobial formulation for treatment of burns and wounds. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antimicrobial" title="antimicrobial">antimicrobial</a>, <a href="https://publications.waset.org/abstracts/search?q=burn" title=" burn"> burn</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=silver%20NPs" title=" silver NPs"> silver NPs</a> </p> <a href="https://publications.waset.org/abstracts/6458/preparation-and-in-vitro-bactericidal-and-fungicidal-efficiency-of-nanosilvermethylcellulose-hydrogel" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/6458.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">451</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">156</span> Utilization and Characterizations of Olive Oil Industry By-Products</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sawsan%20Dacrory">Sawsan Dacrory</a>, <a href="https://publications.waset.org/abstracts/search?q=Hussein%20Abou-Yousef"> Hussein Abou-Yousef</a>, <a href="https://publications.waset.org/abstracts/search?q=Samir%20Kamel"> Samir Kamel</a>, <a href="https://publications.waset.org/abstracts/search?q=Ragab%20E.%20Abou-Zeid"> Ragab E. Abou-Zeid</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20S.%20Abdel-Aziz"> Mohamed S. Abdel-Aziz</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Elbadry"> Mohamed Elbadry</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A considerable amount of lignocellulosic by-product could be obtained from olive pulp during olive oil extraction industry. The major constituents of the olive pulp are husks and seeds. The separation of each portion of olive pulp (seeds and husks) was carried out by water flotation where seeds were sediment in the bottom. Both seeds and husks were dignified by 15% NaOH followed by complete lignin removal by using sodium chlorite in acidic medium. The isolated holocellulose, α-cellulose, hydrogel and CMC which prepared from cellulose of both seeds and husk fractions were characterized by FTIR and SEM. The present study focused on the investigation of the chemical components of the lignocellulosic fraction of olive pulp. Biofunctionlization of hydrogel was achieved through loading of silver nanoparticles AgNPs in to the prepared hydrogel. The antimicrobial activity of the loaded silver hydrogel against G-ve, and G+ve, and candida was demonstrated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cellulose" title="cellulose">cellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=carboxymethyle%20cellulose" title=" carboxymethyle cellulose"> carboxymethyle cellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=olive%20pulp" title=" olive pulp"> olive pulp</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a> </p> <a href="https://publications.waset.org/abstracts/40837/utilization-and-characterizations-of-olive-oil-industry-by-products" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40837.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">474</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">155</span> Chitosan Hydrogel Containing Nitric Oxide Donors with Potent Antibacterial Effect</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Milena%20Trevisan%20Pelegrino">Milena Trevisan Pelegrino</a>, <a href="https://publications.waset.org/abstracts/search?q=Bruna%20De%20Araujo%20Lima"> Bruna De Araujo Lima</a>, <a href="https://publications.waset.org/abstracts/search?q=M%C3%B4nica%20%20H.%20M.%20Do%20Nascimento"> Mônica H. M. Do Nascimento</a>, <a href="https://publications.waset.org/abstracts/search?q=Christiane%20B.%20Lombello"> Christiane B. Lombello</a>, <a href="https://publications.waset.org/abstracts/search?q=Marcelo%20Brocchi"> Marcelo Brocchi</a>, <a href="https://publications.waset.org/abstracts/search?q=Amedea%20B.%20Seabra"> Amedea B. Seabra</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nitric oxide (NO) is a small molecule involved in a wide range of physiological and pathophysiological processes, including vasodilatation, control of inflammatory pain, wound healing, and antibacterial activities. As NO is a free radical, the design of drugs that generates therapeutic amounts of NO in controlled spatial and time manners is still a challenge. In this study, the NO donor S-nitrosoglutathione (GSNO) was incorporated into the thermoresponsive Pluronic F-127 (PL) - chitosan (CS) hydrogel, in an easy and economically feasible methodology. CS is a polysaccharide with known antimicrobial and biocompatibility properties. Scanning electron microscopy, rheology and differential scanning calorimetry techniques were used for hydrogel characterization. The results demonstrated that the hydrogel has a smooth surface, thermoresponsive behavior, and good mechanical stability. The kinetics of NO release and GSNO diffusion from GSNO-containing PL/CS hydrogel demonstrated a sustained NO/GSNO release, in concentrations suitable for biomedical applications, at physiological and skin temperatures. The GSNO-PL/CS hydrogel demonstrated a concentration-dependent toxicity to Vero cells, and antimicrobial activity to Pseudomonas aeruginosa (minimum inhibitory concentration and minimum bactericidal concentration values of 0.5 µg·mL-1 of hydrogel, which correspondents to 1 mmol·L-1 of GSNO). Interesting, the concentration range in which the NO-releasing hydrogel demonstrated antibacterial effect was not found toxic to Vero mammalian cell. Thus, GSNO-PL/CS hydrogel is suitable biomaterial for topical NO delivery applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antimicrobial" title="antimicrobial">antimicrobial</a>, <a href="https://publications.waset.org/abstracts/search?q=chitosan" title=" chitosan"> chitosan</a>, <a href="https://publications.waset.org/abstracts/search?q=biocompatibility" title=" biocompatibility"> biocompatibility</a>, <a href="https://publications.waset.org/abstracts/search?q=S-nitrosothiols" title=" S-nitrosothiols"> S-nitrosothiols</a> </p> <a href="https://publications.waset.org/abstracts/91507/chitosan-hydrogel-containing-nitric-oxide-donors-with-potent-antibacterial-effect" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/91507.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">185</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">154</span> Preparation of Biomedical Hydrogels Using Phenolic Compounds and Electron Beam Irradiation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farnaz%20Sadeghi">Farnaz Sadeghi</a>, <a href="https://publications.waset.org/abstracts/search?q=Moslem%20Tavakol"> Moslem Tavakol</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, an attempt has been made to prepare a physically cross-linked gel by cooling of tannic acid (TA)-polyvinyl alcohol (PVA) solution that subsequently convert to antibacterial chemically cross-linked hydrogel by using electron beam irradiation. PVA is known for its biocompatibility and hydrophilicity, and TA is known for being a natural compound which can serve as a cross-linking agent and a therapeutic agent. Swelling behavior, gel content, pore size, and mechanical properties of hydrogels which prepared at 14, 28, and 56 (kGy) with diﬀerent ratios of polymers were investigated. PVA-TA hydrogel showed sustained release of tannic acid as approximately 20% and 50% of loaded TA released from the hydrogel after 4 and 72 h release time. We found that gel content decreased and the moisture retention capability increased by an increase in TA composition. In addition, PVA-TA hydrogels showed a good antibacterial activity against S.aureus. MTT analysis indicated that close to 83% of fibroblast cells remained viable after 48 h exposure to hydrogel extract. Moreover, the cooling of 10% PVA solution containing 0.5 and 0.75% w/v tannic acid to room and refrigerator, respectively, led to formation of physical gel that did not present any flow index after inversion of hydrogel cast. According to the results, the hydrogel prepared by electron beam irradiation of blended PVA-TA solution could be further investigated as a promising candidate for wound healing. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=poly%20vinyl%20alcohol" title="poly vinyl alcohol">poly vinyl alcohol</a>, <a href="https://publications.waset.org/abstracts/search?q=tannic%20acid" title=" tannic acid"> tannic acid</a>, <a href="https://publications.waset.org/abstracts/search?q=electron%20beam%20irradiation" title=" electron beam irradiation"> electron beam irradiation</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel%20wound%20dressing" title=" hydrogel wound dressing"> hydrogel wound dressing</a> </p> <a href="https://publications.waset.org/abstracts/141746/preparation-of-biomedical-hydrogels-using-phenolic-compounds-and-electron-beam-irradiation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141746.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">154</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">153</span> Self-Healing Hydrogel Triggered by Magnetic Microspheres to Control Glutathione Release for Cartilage Repair</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I-Yun%20Cheng">I-Yun Cheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Min-Yu%20Chiang"> Min-Yu Chiang</a>, <a href="https://publications.waset.org/abstracts/search?q=Shwu-Jen%20Chang"> Shwu-Jen Chang</a>, <a href="https://publications.waset.org/abstracts/search?q=San-Yuan%20Chen"> San-Yuan Chen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Osteoarthritis (OA) is among the most challenging joint diseases, and as far as we know, there is currently no exact and effective cure for it because it has low self-repair ability due to lack of blood vessels and low cell density in articular cartilage. So far, there have been several methods developed to treat cartilage disorder. The most common method is to treat the high molecular weight of hyaluronic acid (HA) injection, but it will degrade after a period of time, so the patients need to inject HA repeatedly. In recent years, self-healing hydrogel has drawn considerable attention because it can recover its initial mechanical properties after damaged and further increase the lifetime of the hydrogel. Here, we aim to develop a self-healable composite hydrogel combined with magnetic microspheres to trigger glutathione(GSH) release for promoting cartilage repair. We use HA-cyclodextrin (CD) as host polymer and poly(acrylic acid)-ferrocene (pAA-Fc) as guest polymer to form the self-healable HA-pAA hydrogel by host and guest interaction where various graft amount of pAA-Fc (pAA:Fc= 1:2, 1:1.5, 1:1, 2:1, 4:1) was conducted to develop different mechanical strength hydrogel. The rheology analysis showed that the 4:1 of pAA-Fc has higher mechanical strength than other formulations. On the other hand, iron oxide nanoparticle, poly(lactic-co-glycolic acid) (PLGA) and polyethyleneimine (PEI) were used to synthesize porous magnetic microspheres via double emulsification water-in-oil-in-water (W/O/W) to increase GSH loading which acted as a reductant to control the hydrogel crosslink density and promote hydrogel self-healing. The results show that the porous magnetic microspheres can be loaded with 70% of GSH and sustained release about 50% of GSH after 24 hours. More importantly, the HA-pAA composite hydrogel can self-heal rapidly within 24 hours when suffering external force destruction by releasing GSH from the magnetic microspheres. Therefore, the developed the HA-pAA composite hydrogel combined with GSH-loaded magnetic microspheres can be in-vivo guided to damaged OA surface for inducing the cartilage repair by controlling the crosslinking of self-healing hydrogel via GSH release. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=articular%20cartilage" title="articular cartilage">articular cartilage</a>, <a href="https://publications.waset.org/abstracts/search?q=magnetic%20microsphere" title=" magnetic microsphere"> magnetic microsphere</a>, <a href="https://publications.waset.org/abstracts/search?q=osteoarthritis" title=" osteoarthritis"> osteoarthritis</a>, <a href="https://publications.waset.org/abstracts/search?q=self-healing%20hydrogel" title=" self-healing hydrogel"> self-healing hydrogel</a> </p> <a href="https://publications.waset.org/abstracts/106078/self-healing-hydrogel-triggered-by-magnetic-microspheres-to-control-glutathione-release-for-cartilage-repair" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/106078.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">132</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">152</span> Preparation and In vitro Characterization of Nanoparticle Hydrogel for Wound Healing</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rajni%20Kant%20Panik">Rajni Kant Panik</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of the present study was to develop and evaluate mupirocin loaded nanoparticle incorporated into hydrogel as an infected wound healer. Incorporated Nanoparticle in hydrogel provides a barrier that effectively prevents the contamination of the wound and further progression of infection to deeper tissues. Hydrogel creates moist healing environment on wound space with good fluid absorbance. Nanoparticles were prepared by double emulsion solvent evaporation method using different ratios of PLGA polymer and the hydrogels was developed using sodium alginate and gelatin. Further prepared nanoparticles were then incorporated into the hydrogels. The formulations were characterized by FT-IR and DSC for drug and polymer compatibility and surface morphology was studied by TEM. Nanoparticle hydrogel were evaluated for their size, shape, encapsulation efficiency and for in vitro studies. The FT-IR and DSC confirmed the absence of any drug polymer interaction. The average size of Nanoparticle was found to be in range of 208.21-412.33 nm and shape was found to be spherical. The maximum encapsulation efficiency was found to be 69.03%. The in vitro release profile of Nanoparticle incorporated hydrogel formulation was found to give sustained release of drug. Antimicrobial activity testing confirmed that encapsulated drug preserve its effectiveness. The stability study confirmed that the formulation prepared were stable. Present study complements our finding that mupirocin loaded Nanoparticle incorporated into hydrogel has the potential to be an effective and safe novel addition for the release of mupirocin in sustained manner, which may be a better option for the management of wound. These finding also supports the progression of antibiotic via hydrogel delivery system is a novel topical dosage form for the management of wound. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title="hydrogel">hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticle" title=" nanoparticle"> nanoparticle</a>, <a href="https://publications.waset.org/abstracts/search?q=PLGA" title=" PLGA"> PLGA</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20healing" title=" wound healing"> wound healing</a> </p> <a href="https://publications.waset.org/abstracts/47734/preparation-and-in-vitro-characterization-of-nanoparticle-hydrogel-for-wound-healing" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/47734.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">311</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">151</span> Design and Fabrication of a Scaffold with Appropriate Features for Cartilage Tissue Engineering</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20S.%20Salehi">S. S. Salehi</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Shamloo"> A. Shamloo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Poor ability of cartilage tissue when experiencing a damage leads scientists to use tissue engineering as a reliable and effective method for regenerating or replacing damaged tissues. An artificial tissue should have some features such as biocompatibility, biodegradation and, enough mechanical properties like the original tissue. In this work, a composite hydrogel is prepared by using natural and synthetic materials that has high porosity. Mechanical properties of different combinations of polymers such as modulus of elasticity were tested, and a hydrogel with good mechanical properties was selected. Bone marrow derived mesenchymal stem cells were also seeded into the pores of the sponge, and the results showed the adhesion and proliferation of cells within the hydrogel after one month. In comparison with previous works, this study offers a new and efficient procedure for the fabrication of cartilage like tissue and further cartilage repair. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cartilage%20tissue%20engineering" title="cartilage tissue engineering">cartilage tissue engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=mechanical%20strength" title=" mechanical strength"> mechanical strength</a>, <a href="https://publications.waset.org/abstracts/search?q=mesenchymal%20stem%20cell" title=" mesenchymal stem cell"> mesenchymal stem cell</a> </p> <a href="https://publications.waset.org/abstracts/65407/design-and-fabrication-of-a-scaffold-with-appropriate-features-for-cartilage-tissue-engineering" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/65407.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">300</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">150</span> Swelling Behaviour of Kappa Carrageenan Hydrogel in Neutral Salt Solution</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sperisa%20Distantina">Sperisa Distantina</a>, <a href="https://publications.waset.org/abstracts/search?q=Fadilah%20Fadilah"> Fadilah Fadilah</a>, <a href="https://publications.waset.org/abstracts/search?q=Mujtahid%20Kaavessina"> Mujtahid Kaavessina</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hydrogel films were prepared from kappa carrageenan by crosslinking with glutaraldehyde. Carrageenan films extracted from <em>Kappaphycus alvarezii</em> seaweed were immersed in glutaraldehyde solution for 2 min and then cured at 110 °C for 25 min. The obtained crosslinked films were washed with ethanol to remove the unreacted glutaraldehyde and then air dried to constant weights. The aim of this research was to study the swelling degree behaviour of the hydrogel film to neutral salts solution, namely NaCl, KCl, and CaCl<sub>2</sub>. The results showed that swelling degree of crosslinked films varied non-monotonically with salinity of NaCl. Swelling degree decreased with the increasing of KCl concentration. Swelling degree of crosslinked film in CaCl<sub>2 </sub>solution was lower than that in NaCl and in KCl solutions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carrageenan" title="carrageenan">carrageenan</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=glutaraldehyde" title=" glutaraldehyde"> glutaraldehyde</a>, <a href="https://publications.waset.org/abstracts/search?q=salt" title=" salt"> salt</a>, <a href="https://publications.waset.org/abstracts/search?q=swelling" title=" swelling"> swelling</a> </p> <a href="https://publications.waset.org/abstracts/46588/swelling-behaviour-of-kappa-carrageenan-hydrogel-in-neutral-salt-solution" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46588.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">244</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">149</span> Remote Controlled of In-Situ Forming Thermo-sensitive Hydrogel Nanocomposite for Hyperthermia Therapy Application: Synthesis and Characterizations</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Elbadawy%20A.%20Kamoun">Elbadawy A. Kamoun</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Magnetically responsive hydrogel nanocomposite (NCH) based on composites of superparamagnetic of Fe3O4 nano-particles and temperature responsive hydrogel matrices were developed. The nanocomposite hydrogel system based on the temperature sensitive N-isopropylacrylamide hydrogels crosslinked by poly(ethylene glycol)-400 dimethacrylate (PEG400DMA) incorporating with chitosan derivative, was synthesized and characterized. Likewise, the NCH system was synthesized by visible-light free radical photopolymerization, using carboxylated camphorquinone-amine system to avoid the common risks of the use of UV-light especially in hyperthermia treatment. Superparamagnetic of iron oxide nanoparticles were introduced into the hydrogel system by polymerizing mixture technique and monomer solution. FT-IR with Raman spectroscopy and Wide angle-XRD analysis were utilized to verify the chemical structure of NCH and exfoliation reaction for nanoparticles, respectively. Additionally, morphological structure of NCH was investigated using SEM and TEM photographs. The swelling responsive of the current nanocomposite hydrogel system with different crosslinking conditions, temperature, magnetic field efficiency, and the presence effect of magnetic nanoparticles were evaluated. Notably, hydrolytic degradation of this system was proved in vitro application. While, in-vivo release profile behavior is under investigation nowadays. Moreover, the compatibility and cytotoxicity tests were previously investigated in our studies for photoinitiating system. These systems show promised polymeric material candidate devices and are expected to have a wide applicability in various biomedical applications as mildly. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydrogel%20nanocomposites" title="hydrogel nanocomposites">hydrogel nanocomposites</a>, <a href="https://publications.waset.org/abstracts/search?q=tempretaure-responsive%20hydrogel" title=" tempretaure-responsive hydrogel"> tempretaure-responsive hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=superparamagnetic%20nanoparticles" title=" superparamagnetic nanoparticles"> superparamagnetic nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=hyperthermia%20therapy" title=" hyperthermia therapy"> hyperthermia therapy</a> </p> <a href="https://publications.waset.org/abstracts/13516/remote-controlled-of-in-situ-forming-thermo-sensitive-hydrogel-nanocomposite-for-hyperthermia-therapy-application-synthesis-and-characterizations" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13516.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">279</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">148</span> Osteogenesis in Thermo-Sensitive Hydrogel Using Mesenchymal Stem Cell Derived from Human Turbinate</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20Reum%20Son">A. Reum Son</a>, <a href="https://publications.waset.org/abstracts/search?q=Jin%20Seon%20Kwon"> Jin Seon Kwon</a>, <a href="https://publications.waset.org/abstracts/search?q=Seung%20Hun%20Park"> Seung Hun Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Hai%20Bang%20Lee"> Hai Bang Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Moon%20Suk%20Kim"> Moon Suk Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> These days, stem cell therapy is focused on for promising source of treatment in clinical human disease. As a supporter of stem cells, in situ-forming hydrogels with growth factors and cells appear to be a promising approach in tissue engineering. To examine osteogenic differentiation of hTMSCs which is one of mesenchymal stem cells in vivo in an injectable hydrogel, we use a methoxy polyethylene glycol-polycaprolactone blockcopolymer (MPEG-PCL) solution with osteogenic factors. We synthesized MPEG-PCL hydrogel and measured viscosity to check sol-gel transition. In order to demonstrate osteogenic ability of hTMSCs, we conducted in vitro osteogenesis experiment. Then, to confirm the cell cytotoxicity, we performed WST-1 with hTMSCs and MPEG-PCL. As the result of in vitro experiment, we implanted cell and hydrogel mixture into animal model and checked degree of osteogenesis with histological analysis and amount of expression genes. Through these experimental data, MPEG-PCL hydrogel has sol-gel transition in temperature change and is biocompatible with stem cells. In histological analysis and gene expression, hTMSCs are very good source of osteogenesis with hydrogel and will use it to tissue engineering as important treatment method. hTMSCs could be a good adult stem cell source for usability of isolation and high proliferation. When hTMSCs are used as cell therapy method with in situ-formed hydrogel, they may provide various benefits like a noninvasive alternative for bone tissue engineering applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=injectable%20hydrogel" title="injectable hydrogel">injectable hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=stem%20cell" title=" stem cell"> stem cell</a>, <a href="https://publications.waset.org/abstracts/search?q=osteogenic%20differentiation" title=" osteogenic differentiation"> osteogenic differentiation</a>, <a href="https://publications.waset.org/abstracts/search?q=tissue%20engineering" title=" tissue engineering"> tissue engineering</a> </p> <a href="https://publications.waset.org/abstracts/9285/osteogenesis-in-thermo-sensitive-hydrogel-using-mesenchymal-stem-cell-derived-from-human-turbinate" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9285.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">447</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">147</span> Quantitative Evaluation of Diabetic Foot Wound Healing Using Hydrogel Nanosilver Based Dressing vs. Traditional Dressing: A Prospective Randomized Control Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ehsan%20A.%20Yahia">Ehsan A. Yahia</a>, <a href="https://publications.waset.org/abstracts/search?q=Ayman%20E.%20El-Sharkawey"> Ayman E. El-Sharkawey</a>, <a href="https://publications.waset.org/abstracts/search?q=Magda%20M.%20Bayoumi"> Magda M. Bayoumi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Wound dressings perform a crucial role in cutaneous wound management due to their ability to protect wounds and promote dermal and epidermal tissue regeneration. Aim: To evaluate the effectiveness of using hydrogel/nano silver-based dressing vs. traditional dressing on diabetic foot wound healing. Methods: Sixty patients with type-2 diabetes hospitalized for diabetic foot wound treatment were recruited from selected Surgical departments. A prospective randomized control study was carried. Results: The results showed that the percentage of a reduction rate of the ulcer by the third week of the treatment in the hydrogel/nano silver-based dressing group was higher (15.11%) than in the traditional wound dressing group (33.44%). Moreover, the mean ulcer size "sq mm" in the hydrogel/nano silver-based dressing group recognized a faster healing rate (15.11±7.89) and considerably lesser in comparison to the traditional in the third week (21.65±8.4). Conclusion: The hydrogel/nanosilver-based dressing showed better results than traditional dressing in managing diabetic ulcer foot. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes" title="diabetes">diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20care" title=" wound care"> wound care</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20foot" title=" diabetic foot"> diabetic foot</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20dressing" title=" wound dressing"> wound dressing</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel%20nanosilver" title=" hydrogel nanosilver"> hydrogel nanosilver</a> </p> <a href="https://publications.waset.org/abstracts/152560/quantitative-evaluation-of-diabetic-foot-wound-healing-using-hydrogel-nanosilver-based-dressing-vs-traditional-dressing-a-prospective-randomized-control-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152560.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">113</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">146</span> Experimental and Finite Element Analysis of Large Deformation Characteristics of Magnetic Responsive Hydrogel Nanocomposites Membranes</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mallikarjunachari%20Gangapuram">Mallikarjunachari Gangapuram</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Stimuli-responsive hydrogel nanocomposite membranes are gaining significant attention these days due to their potential applications in various engineering fields. For example, sensors, soft actuators, drug delivery, remote controlled therapy, water treatment, shape morphing, and magnetic refrigeration are few advanced applications of hydrogel nanocomposite membranes. In this work, hydrogel nanocomposite membranes are synthesized by embedding nanometer-sized (diameter - 300 nm) Fe₃O₄ magnetic particles into the polyvinyl alcohol (PVA) polymer. To understand the large deformation characteristics of these membranes, a well-known experimental method ball indentation technique is used. Different designing parameters such as membrane thickness, the concentration of magnetic particles and ball diameter on the viscoelastic properties are studied. All the experiments are carried out without and with a static magnetic field. Finite element simulations are carried out to validate the experimental results. It is observed, the creep response decreases and Young’s modulus increases as the thickness and concentration of magnetic particles increases. Image analysis revealed the hydrogel membranes are undergone global deformation for ball diameter 18 mm and local deformation when the diameter decreases from 18 mm to 0.5 mm. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ball%20indentation" title="ball indentation">ball indentation</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel%20membranes" title=" hydrogel membranes"> hydrogel membranes</a>, <a href="https://publications.waset.org/abstracts/search?q=nanocomposites" title=" nanocomposites"> nanocomposites</a>, <a href="https://publications.waset.org/abstracts/search?q=Young%27s%20modulus" title=" Young's modulus"> Young's modulus</a> </p> <a href="https://publications.waset.org/abstracts/105918/experimental-and-finite-element-analysis-of-large-deformation-characteristics-of-magnetic-responsive-hydrogel-nanocomposites-membranes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/105918.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">128</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">145</span> Arsenic Removal from Drinking Water by Hybrid Hydrogel-Biochar Matrix: An Understanding of Process Parameters</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vibha%20Sinha">Vibha Sinha</a>, <a href="https://publications.waset.org/abstracts/search?q=Sumedha%20Chakma"> Sumedha Chakma</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Arsenic (As) contamination in drinking water is a serious concern worldwide resulting in severe health maladies. To tackle this problem, several hydrogel based matrix which selectively uptake toxic metals from contaminated water has increasingly been examined as a potential practical method for metal removal. The major concern in hydrogels is low stability of matrix, resulting in poor performance. In this study, the potential of hybrid hydrogel-biochar matrix synthesized from natural plant polymers, specific for As removal was explored. Various compositional and functional group changes of the elements contained in the matrix due to the adsorption of As were identified. Moreover, to resolve the stability issue in hydrogel matrix, optimum and effective mixing of hydrogel with biochar was studied. Mixing varied proportions of matrix components at the time of digestion process was tested. Preliminary results suggest that partial premixing methods may increase the stability and reduce cost. Addition of nanoparticles and specific catalysts with different concentrations of As(III) and As(V) under batch conditions was performed to study their role in performance enhancement of the hydrogel matrix. Further, effect of process parameters, optimal uptake conditions and detailed mechanism derived from experimental studies were suitably conducted. This study provides an efficient, specific and a low-cost As removal method that offers excellent regeneration abilities which can be reused for value. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=arsenic" title="arsenic">arsenic</a>, <a href="https://publications.waset.org/abstracts/search?q=catalysts" title=" catalysts"> catalysts</a>, <a href="https://publications.waset.org/abstracts/search?q=hybrid%20hydrogel-biochar" title=" hybrid hydrogel-biochar"> hybrid hydrogel-biochar</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20purification" title=" water purification"> water purification</a> </p> <a href="https://publications.waset.org/abstracts/93425/arsenic-removal-from-drinking-water-by-hybrid-hydrogel-biochar-matrix-an-understanding-of-process-parameters" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/93425.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">189</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">144</span> Effects of Injectable Thermosensitive Hydrogel Containing Chitosan as a Barrier for Prevention of Post-operative Peritoneal Adhesion in Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sara%20Javanmardi">Sara Javanmardi</a>, <a href="https://publications.waset.org/abstracts/search?q=Sepehr%20Aziziz"> Sepehr Aziziz</a>, <a href="https://publications.waset.org/abstracts/search?q=Baharak%20Divband"> Baharak Divband</a>, <a href="https://publications.waset.org/abstracts/search?q=Masoumeh%20Firouzamandi"> Masoumeh Firouzamandi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Post-operative adhesions are the most common cause of intestinal obstruction, female infertility and chronic abdominal pain. We developed a novel approach for preventing post-operative peritoneal adhesions using a biodegradable and thermosensitive curcumin hydrogel in rats. Thirteen male Sprague-Dawley rats were assigned randomly into five groups of six animals each: In SHAM group, the cecum was exteriorized, gently manipulated and sent back into the abdomen. In CONTROL group, the surgical abrasion was performed with no further treatment. In Hydrogel group, surgical abrasion was performed with local application of blank hydrogel (1 mL). In Curcumin group, surgical abrasion was performed with local application of curcumin (1 mL). In CUR/HGEL group, surgical abrasion was performed with local application of curcumin hydrogel (1 mL). On day 10, adhesions were assessed using a standardized scale (Evans model), and samples were collected for the Real-time PCR. Real-time PCR was performed to determine mRNA levels of VCAM-1, ICAM-1 and GAPDH. The macroscopic adhesion intensity showed statistically significant differences between the CUR/HGEL and other groups (P=0.0005). The findings of the present study revealed there were statistically significant differences between the groups regarding adhesion band length and numbers (P<0.0001). The protein and mRNA expression of VCAM-1 and ICAM-1 in secal tissues were significantly down regulated due to curcumin-hydrogel application in CUR/HGEL compared to other groups (p<0.05). The thermosensitive hydrogel could reduce the severity and even prevent formation of intra-abdominal adhesion. Curcumin hydrogel could serve as a potential barrier agent to prevent post-operative peritoneal adhesion in rats. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=peritoneal%20adhesion" title="peritoneal adhesion">peritoneal adhesion</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=curcumijn" title=" curcumijn"> curcumijn</a>, <a href="https://publications.waset.org/abstracts/search?q=ICAM-1" title=" ICAM-1"> ICAM-1</a>, <a href="https://publications.waset.org/abstracts/search?q=VCAM-1" title=" VCAM-1"> VCAM-1</a> </p> <a href="https://publications.waset.org/abstracts/168220/effects-of-injectable-thermosensitive-hydrogel-containing-chitosan-as-a-barrier-for-prevention-of-post-operative-peritoneal-adhesion-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/168220.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">88</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">143</span> Clay Hydrogel Nanocomposite for Controlled Small Molecule Release </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Xiaolin%20Li">Xiaolin Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Terence%20Turney"> Terence Turney</a>, <a href="https://publications.waset.org/abstracts/search?q=John%20Forsythe"> John Forsythe</a>, <a href="https://publications.waset.org/abstracts/search?q=Bryce%20Feltis"> Bryce Feltis</a>, <a href="https://publications.waset.org/abstracts/search?q=Paul%20Wright"> Paul Wright</a>, <a href="https://publications.waset.org/abstracts/search?q=Vinh%20Truong"> Vinh Truong</a>, <a href="https://publications.waset.org/abstracts/search?q=Will%20%20Gates"> Will Gates</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Clay-hydrogel nanocomposites have attracted great attention recently, mainly because of their enhanced mechanical properties and ease of fabrication. Moreover, the unique platelet structure of clay nanoparticles enables the incorporation of bioactive molecules, such as proteins or drugs, through ion exchange, adsorption or intercalation. This study seeks to improve the mechanical and rheological properties of a novel hydrogel system, copolymerized from a tetrapodal polyethylene glycol (PEG) thiol and a linear, triblock PEG-PPG-PEG (PPG: polypropylene glycol) α,ω-bispropynoate polymer, with the simultaneous incorporation of various amounts of Na-saturated, montmorillonite clay (MMT) platelets (av. lateral dimension = 200 nm), to form a bioactive three-dimensional network. Although the parent hydrogel has controlled swelling ability and its PEG groups have good affinity for the clay platelets, it suffers from poor mechanical stability and is currently unsuitable for potential applications. Nanocomposite hydrogels containing 4wt% MMT showed a twelve-fold enhancement in compressive strength, reaching 0.75MPa, and also a three-fold acceleration in gelation time, when compared with the parent hydrogel. Interestingly, clay nanoplatelet incorporation into the hydrogel slowed down the rate of its dehydration in air. Preliminary results showed that protein binding by the MMT varied with the nature of the protein, as horseradish peroxidase (HRP) was more strongly bound than bovine serum albumin. The HRP was no longer active when bound, presumably as a result of extensive structural refolding. Further work is being undertaken to assess protein binding behaviour within the nanocomposite hydrogel for potential diabetic wound healing applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title="hydrogel">hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=nanocomposite" title=" nanocomposite"> nanocomposite</a>, <a href="https://publications.waset.org/abstracts/search?q=small%20molecule" title=" small molecule"> small molecule</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20healing" title=" wound healing"> wound healing</a> </p> <a href="https://publications.waset.org/abstracts/67488/clay-hydrogel-nanocomposite-for-controlled-small-molecule-release" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67488.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">269</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">142</span> Mass Transfer of Paracetamol from the Crosslinked Carrageenan-Polyvinyl Alcohol Film</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sperisa%20Distantina">Sperisa Distantina</a>, <a href="https://publications.waset.org/abstracts/search?q=Rieke%20Ulfha%20Noviyanti"> Rieke Ulfha Noviyanti</a>, <a href="https://publications.waset.org/abstracts/search?q=Sri%20Sutriyani"> Sri Sutriyani</a>, <a href="https://publications.waset.org/abstracts/search?q=Fadilah%20Fadilah"> Fadilah Fadilah</a>, <a href="https://publications.waset.org/abstracts/search?q=Mujtahid%20Kaavessina"> Mujtahid Kaavessina</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this research, carrageenan extracted from seaweed Eucheuma cottonii was mixed with polyvinyl alcohol (PVA) and then crosslinked using glutaraldehyde (GA). The obtained hydrogel films were applied to control the drug release rate of paracetamol. The aim of this research was to develop a mathematical model that can be used to describe the mass transfer rate of paracetamol from the hydrogel film into buffer solution. The effect of weight ratio carrageenan-PVA (5: 0, 1: 0.5, 1: 1, 1: 2, 0: 5) on the parameters of the mathematical model was investigated also. Based on the experimental data, the proposed mathematical model could describe the mass transfer rate of paracetamol. The weight ratio of carrageenan-PVA greatly affected the amount of paracetamol absorbed in the hydrogel film and the mass transfer rate of paracetamol. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carrageenan-PVA" title="carrageenan-PVA">carrageenan-PVA</a>, <a href="https://publications.waset.org/abstracts/search?q=crosslinking" title=" crosslinking"> crosslinking</a>, <a href="https://publications.waset.org/abstracts/search?q=glutaraldehyde" title=" glutaraldehyde"> glutaraldehyde</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=paracetamol" title=" paracetamol"> paracetamol</a>, <a href="https://publications.waset.org/abstracts/search?q=mass%20transfer" title=" mass transfer"> mass transfer</a> </p> <a href="https://publications.waset.org/abstracts/67260/mass-transfer-of-paracetamol-from-the-crosslinked-carrageenan-polyvinyl-alcohol-film" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67260.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">293</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">141</span> Spectrophotometric Evaluation of Custom Microalgae-Based Bioink Formulations for Optimized Green Bioprinting</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Olubusuyi%20Ayowole">Olubusuyi Ayowole</a>, <a href="https://publications.waset.org/abstracts/search?q=Bashir%20Khoda"> Bashir Khoda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Green bioprinting, from the context of merging 3D bioprinting with microalgae cell organization, holds promise for industrial-scale optimization. This study employs spectrophotometric analysis to explore post-bioprinting cell growth density variation within hybrid hydrogel biomaterial scaffolds. Three hydrogel biomaterials—Alginic acid sodium salt (ALGINATE), Nanofibrillated Cellulose (NFC) – TEMPO, and CarboxyMethyl Cellulose (CMC)—are chosen for their scaffolding capabilities. Bioink development and analysis of their impact on cell proliferation and morphology are conducted. Chlorella microalgae cell growth within hydrogel compositions is probed using absorbance measurements, with additional assessment of shear thinning properties. Notably, NFC exhibits reduced shear thinning compared to CMC. Results reveal that while mono-hydrogel substrates with pronounced adhesion inhibit Chlorella cell proliferation, Alginate fosters increased cell concentration alongside a slight viscosity rise. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=green%20bioprinting" title="green bioprinting">green bioprinting</a>, <a href="https://publications.waset.org/abstracts/search?q=3d%20bioprinting" title=" 3d bioprinting"> 3d bioprinting</a>, <a href="https://publications.waset.org/abstracts/search?q=microalgae%20cell" title=" microalgae cell"> microalgae cell</a>, <a href="https://publications.waset.org/abstracts/search?q=hybrid%20hydrogel%20scaffolds" title=" hybrid hydrogel scaffolds"> hybrid hydrogel scaffolds</a>, <a href="https://publications.waset.org/abstracts/search?q=spectrophotometric%20analysis" title=" spectrophotometric analysis"> spectrophotometric analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=bioink%20development" title=" bioink development"> bioink development</a>, <a href="https://publications.waset.org/abstracts/search?q=shear%20thinning%20properties" title=" shear thinning properties"> shear thinning properties</a> </p> <a href="https://publications.waset.org/abstracts/188298/spectrophotometric-evaluation-of-custom-microalgae-based-bioink-formulations-for-optimized-green-bioprinting" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188298.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">29</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">140</span> Synthesis of Beetosan's Hydrogels with Yellow Tea</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jolanta%20Jaskowska">Jolanta Jaskowska</a>, <a href="https://publications.waset.org/abstracts/search?q=Anna%20Drabczyk"> Anna Drabczyk</a>, <a href="https://publications.waset.org/abstracts/search?q=Sonia%20Kudlacik"> Sonia Kudlacik</a>, <a href="https://publications.waset.org/abstracts/search?q=Agnieszka%20Sobczak-Kupiec"> Agnieszka Sobczak-Kupiec</a>, <a href="https://publications.waset.org/abstracts/search?q=Bozena%20Tyliszczak"> Bozena Tyliszczak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of the study was to select the best conditions for the synthesis of Beetosan's hydrogels with yellow tea. The study determined recipe hydrogel matrix by selecting the appropriate ratio of substrates and to investigate the effect of yellow tea, on the structure and properties of the hydrogel materials. The scope of the research included both to obtain of raw materials required for the synthesis of hydrogel materials, as well as an assessment of their properties. In the first stage of research Beetosan (chitosan derived from bees), and extract the yellow tea China Kekecha was obtained. The second stage was synthesis hydrogels modified by yellow tea. The synthesis of polymeric matrix was preparation under UV radiation. Obtained hydrogel materials were investigated extensively using incubation investigations, absorption capacity, and spectroscopic (FT-IR) and X-ray diffraction (XRD) methods. Moreover, there was also performed the surface wettability test and a photomicrograph of the structure using scanning electron microscope. Analysis of the obtained results confirms that presence of yellow tea does not significantly affect the behavior of the hydrogels in the incubation fluids. The results show that hydrogel materials exhibit compatibility with the incubatory solutions and they also retain the stability in the tested liquids. Hydrogels obtained in this method might be applied in the cosmetics industry and in the field of medicine. This is possible due to the many interesting properties of tea and biocompatibility and non-toxicity hydrogel materials. The authors would like to thank the The National Centre for Research and Development (Grant no: LIDER/033/697/L-5/13/NCBR/2014) for providing financial support to this project. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Beetosan" title="Beetosan">Beetosan</a>, <a href="https://publications.waset.org/abstracts/search?q=hygrogels" title=" hygrogels"> hygrogels</a>, <a href="https://publications.waset.org/abstracts/search?q=materials" title=" materials"> materials</a>, <a href="https://publications.waset.org/abstracts/search?q=yellow%20tea" title=" yellow tea"> yellow tea</a> </p> <a href="https://publications.waset.org/abstracts/68058/synthesis-of-beetosans-hydrogels-with-yellow-tea" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/68058.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">275</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">139</span> Controlled Release of Curcumin from a Thermoresponsive Polypeptide Hydrogel for Anti-Tumor Therapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chieh-Nan%20Chen">Chieh-Nan Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Ji-Yu%20Lin"> Ji-Yu Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=I-Ming%20Chu"> I-Ming Chu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Polypeptide thermosensitive hydrogel is an excellent candidate as a smart device to deliver drugs and cells due to its remarkable biocompatibility, low gelation concentration, and respond to temperature stimuli, it can be easily injected as a polymer solution into the patient’s body where it undergoes gelation due to an elevation in temperature. Poly (ethylene glycol) monomethyl ether-poly (ethyl-l-glutamate) (mPEG-PELG) contains a hydrophobic side chain –C2H5 which is useful in encapsulating and stabilizing hydrophobic drugs. In this study, we plan to focus on the hydrophobic anti-carcinogenic and anti-inflammatory drug curcumin, which due its insolubility in water, requires a proper carrier for delivery into the body. Our main concept is to use mPEG-PELG to stabilize curcumin, inject the curcumin-loaded hydrogel into the tumor site, and allow the enzymatically-sensitive hydrogel to be degraded by bodily fluids and release the drug. The polymers of interest have been successfully synthesized and characterized by 1H-NMR, FT-IR, SEM, and CMC. Curcumin loading content and drug release were assayed using HPLC. Preliminary results show that these materials have potential as a delivery vehicle for poorly soluble drugs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=curcumin" title="curcumin">curcumin</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title=" drug release"> drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=polypeptide%20material" title=" polypeptide material"> polypeptide material</a> </p> <a href="https://publications.waset.org/abstracts/46020/controlled-release-of-curcumin-from-a-thermoresponsive-polypeptide-hydrogel-for-anti-tumor-therapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46020.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">293</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">138</span> Nanocellulose Incorporated Polyvinyl Alcohol Hydrogel</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rosli%20Mohd%20Yunus">Rosli Mohd Yunus</a>, <a href="https://publications.waset.org/abstracts/search?q=Zianor%20Azrina%20Zianon%20Abdin"> Zianor Azrina Zianon Abdin</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Dalour%20Hossen%20Beg"> Mohammad Dalour Hossen Beg</a>, <a href="https://publications.waset.org/abstracts/search?q=Ridzuan%20Ramli"> Ridzuan Ramli </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Recently, nanocrystalline cellulose (NCC) has gained considerable interest as a promising biomaterial due to their outstanding properties such as high surface area, high mechanical properties, hydrophilicity, biocompatibility and biodegradability. The NCC also has good stability in water which is compatible for mixing of water based polymer solution or emulsions with NCC. Oil palm empty fruit bunch (EFB) contained different amount of lignocellulosic materials such as lignin, hemicellulose and cellulose. Cellulose is the most significant materials that can be extracted from EFB as nanocrystalline cellulose (NCC). In this work the nanocrystalline cellulose were produced through acid hydrolysis together with ultrasound technique. The morphology of NCC was characterized by TEM, thermal behavior has been studied with DSC, TGA analysis. Structural properties were illustrated X-Ray diffraction as well as FTIR. The hydrogel was produced using polyvinyl alcohol (PVA) with different concentration of NCC. The hydrogel composite was characterized by swelling ratio, crosslinking density, mechanical properties and morphology. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanocellulose" title="nanocellulose">nanocellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=oil%20palm" title=" oil palm"> oil palm</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20treatment" title=" water treatment"> water treatment</a> </p> <a href="https://publications.waset.org/abstracts/49487/nanocellulose-incorporated-polyvinyl-alcohol-hydrogel" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/49487.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">269</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">137</span> poly(N-Isopropylacrylamide)-Polyvinyl Alcohol Semi-Interpenetrating Network Hydrogel for Wound Dressing</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zi-Yan%20Liao">Zi-Yan Liao</a>, <a href="https://publications.waset.org/abstracts/search?q=Shan-Yu%20Zhang"> Shan-Yu Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Ya-Xian%20Lin"> Ya-Xian Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=Ya-Lun%20Lee"> Ya-Lun Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Shih-Chuan%20Huang"> Shih-Chuan Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Hong-Ru%20Lin"> Hong-Ru Lin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Traditional wound dressings, such as gauze, bandages, etc., are easy to adhere to the tissue fluid exuded from the wound, causing secondary damage to the wound during removal. This study takes this as the idea to develop a hydrogel dressing, to explore that the dressing will not cause secondary damage to the wound when it is torn off, and at the same time, create an environment conducive to wound healing. First, the temperature-sensitive material N-isopropylacrylamide (NIPAAm) was used as the substrate. Due to its low mechanical properties, the hydrogel would break due to pulling during human activities. Polyvinyl alcohol (PVA) interpenetrates into it to enhance the mechanical properties, and a semi-interpenetration (semi-IPN) composed of poly(N-isopropylacrylamide) (PNIPAAm) and polyvinyl alcohol (PVA) was prepared by free radical polymerization. PNIPAAm was cross-linked with N,N'-methylenebisacrylamide (NMBA) in an ice bath in the presence of linear PVA, and tetramethylhexamethylenediamine (TEMED) was added as a promoter to speed up the gel formation. The polymerization stage was carried out at 16°C for 17 hours and washed with distilled water for three days after gel formation, and the water was changed several times in the middle to complete the preparation of semi-IPN hydrogel. Finally, various tests were used to analyze the effects of different ratios of PNIPAAm and PVA on semi-IPN hydrogels. In the swelling test, it was found that the maximum swelling ratio can reach about 50% under the environment of 21°C, and the higher the ratio of PVA, the more water can be absorbed. The saturated moisture content test results show that when more PVA is added, the higher saturated water content. The water vapor transmission rate test results show that the value of the semi-IPN hydrogel is about 57 g/m²/24hr, which is not much related to the proportion of PVA. It is found in the LCST test compared with the PNIPAAm hydrogel; the semi-IPN hydrogel possesses the same critical solution temperature (30-35°C). The semi-IPN hydrogel prepared in this study has a good effect on temperature response and has the characteristics of thermal sensitivity. It is expected that after improvement, it can be used in the treatment of surface wounds, replacing the traditional dressing shortcoming. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title="hydrogel">hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=N-isopropylacrylamide" title=" N-isopropylacrylamide"> N-isopropylacrylamide</a>, <a href="https://publications.waset.org/abstracts/search?q=polyvinyl%20alcohol" title=" polyvinyl alcohol"> polyvinyl alcohol</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel%20wound%20dressing" title=" hydrogel wound dressing"> hydrogel wound dressing</a>, <a href="https://publications.waset.org/abstracts/search?q=semi-interpenetrating%20polymer%20network" title=" semi-interpenetrating polymer network"> semi-interpenetrating polymer network</a> </p> <a href="https://publications.waset.org/abstracts/159698/polyn-isopropylacrylamide-polyvinyl-alcohol-semi-interpenetrating-network-hydrogel-for-wound-dressing" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/159698.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">80</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">136</span> Synthesis and Characterisation of Starch-PVP as Encapsulation Material for Drug Delivery System </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nungki%20Rositaningsih">Nungki Rositaningsih</a>, <a href="https://publications.waset.org/abstracts/search?q=Emil%20Budianto"> Emil Budianto</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Starch has been widely used as an encapsulation material for drug delivery system. However, starch hydrogel is very easily degraded during metabolism in human stomach. Modification of this material is needed to improve the encapsulation process in drug delivery system, especially for gastrointestinal drug. In this research, three modified starch-based hydrogels are synthesized i.e. Crosslinked starch hydrogel, Semi- and Full- Interpenetrating Polymer Network (IPN) starch hydrogel using Poly(N-Vinyl-Pyrrolidone). Non-modified starch hydrogel was also synthesized as a control. All of those samples were compared as biomaterials, floating drug delivery, and their ability in loading drug test. Biomaterial characterizations were swelling test, stereomicroscopy observation, Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared Spectroscopy (FTIR). Buoyancy test and stereomicroscopy scanning were done for floating drug delivery characterizations. Lastly, amoxicillin was used as test drug, and characterized with UV-Vis spectroscopy for loading drug observation. Preliminary observation showed that Full-IPN has the most dense and elastic texture, followed by Semi-IPN, Crosslinked, and Non-modified in the last position. Semi-IPN and Crosslinked starch hydrogel have the most ideal properties and will not be degraded easily during metabolism. Therefore, both hydrogels could be considered as promising candidates for encapsulation material. Further analysis and issues will be discussed in the paper. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biomaterial" title="biomaterial">biomaterial</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery%20system" title=" drug delivery system"> drug delivery system</a>, <a href="https://publications.waset.org/abstracts/search?q=interpenetrating%20polymer%20network" title=" interpenetrating polymer network"> interpenetrating polymer network</a>, <a href="https://publications.waset.org/abstracts/search?q=poly%28N-vinyl-pyrrolidone%29" title=" poly(N-vinyl-pyrrolidone)"> poly(N-vinyl-pyrrolidone)</a>, <a href="https://publications.waset.org/abstracts/search?q=starch%20hydrogel" title=" starch hydrogel"> starch hydrogel</a> </p> <a href="https://publications.waset.org/abstracts/56315/synthesis-and-characterisation-of-starch-pvp-as-encapsulation-material-for-drug-delivery-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/56315.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">251</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">135</span> Effect of Swelling Pressure on Drug Release from Polyelectrolyte Micro-Hydrogel Particles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mina%20Boroujerdi">Mina Boroujerdi</a>, <a href="https://publications.waset.org/abstracts/search?q=Javad%20Tavakoli"> Javad Tavakoli</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hydrogels are extensively studied as matrices for the controlled release of drugs. To evaluate the mobility of embedded molecules, these drug delivery systems are usually characterized by release studies. In this contribution, an electronic device for swelling pressure measurement during drug release from hydrogel network was developed. Also, poly acrylic acid micro particles were prepared for prolonged and sustained controlled acetaminophen release. Effect of swelling pressure on drug release from micro particles studied under different environment pH in order to predict release profile in gastro-intestine medium. Swelling ratio and swelling pressure were measured in different pH. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=swelling%20pressure" title="swelling pressure">swelling pressure</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=polyelectrolyte" title=" polyelectrolyte"> polyelectrolyte</a> </p> <a href="https://publications.waset.org/abstracts/54759/effect-of-swelling-pressure-on-drug-release-from-polyelectrolyte-micro-hydrogel-particles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54759.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">299</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">134</span> Ocular Delivery of Charged Drugs Using Iontophoresis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abraham%20J.%20Domb">Abraham J. Domb</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nearly every eye disorder and treatment of post operated eyes evolve around ocular drug delivery. Most ocular diseases are treated with repeated topical applications administered as eye drops. Various attempts have been made to improve drug bioavailability by increasing both the retention of the drug in the pre-corneal area and the penetration of the drug through the cornea. However, currently marketed products are associated with vision blurring, irritability, patient discomfort, toxicity, low drug bioavailability, manufacturing difficulties and inadequate aqueous stability. It has been suggested to use iontophoresis for the non-invasive delivery of drugs. The iontophoretic device is composed of a control panel, two electrodes, a cylindrical well for the insertion of a disposable hydrogel, and a disposable hydrogel pellet. The drug-loaded hydrogel is attached to a cylindrical well at the edge of the electrode of the device and placed onto the eye. The device applies a variable electrical current that can vary from 0.1 mA to 1.5 mA for pre-set periods from 10 seconds to 300 seconds. The iontophoretic device developed in the lab was found to be effective in the delivery of the drugs: gentamicin, water-soluble steroids, and various anticancer agents. When testing in rabbits for safety, the device was considered to be non-toxic and effective. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=iontophoresis" title="iontophoresis">iontophoresis</a>, <a href="https://publications.waset.org/abstracts/search?q=eye%20disorder" title=" eye disorder"> eye disorder</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a> </p> <a href="https://publications.waset.org/abstracts/164928/ocular-delivery-of-charged-drugs-using-iontophoresis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/164928.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">80</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">133</span> Vascularized Adipose Tissue Engineering by Using Adipose ECM/Fibroin Hydrogel</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alisan%20Kayabolen">Alisan Kayabolen</a>, <a href="https://publications.waset.org/abstracts/search?q=Dilek%20Keskin"> Dilek Keskin</a>, <a href="https://publications.waset.org/abstracts/search?q=Ferit%20Avcu"> Ferit Avcu</a>, <a href="https://publications.waset.org/abstracts/search?q=Andac%20Aykan"> Andac Aykan</a>, <a href="https://publications.waset.org/abstracts/search?q=Fatih%20Zor"> Fatih Zor</a>, <a href="https://publications.waset.org/abstracts/search?q=Aysen%20Tezcaner"> Aysen Tezcaner</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Adipose tissue engineering is a promising field for regeneration of soft tissue defects. However, only very thin implants can be used in vivo since vascularization is still a problem for thick implants. Another problem is finding a biocompatible scaffold with good mechanical properties. In this study, the aim is to develop a thick vascularized adipose tissue that will integrate with the host, and perform its in vitro and in vivo characterizations. For this purpose, a hydrogel of decellularized adipose tissue (DAT) and fibroin was produced, and both endothelial cells and adipocytes that were differentiated from adipose derived stem cells were encapsulated in this hydrogel. Mixing DAT with fibroin allowed rapid gel formation by vortexing. It also provided to adjust mechanical strength by changing fibroin to DAT ratio. Based on compression tests, gels of DAT/fibroin ratio with similar mechanical properties to adipose tissue was selected for cell culture experiments. In vitro characterizations showed that DAT is not cytotoxic; on the contrary, it has many natural ECM components which provide biocompatibility and bioactivity. Subcutaneous implantation of hydrogels resulted with no immunogenic reaction or infection. Moreover, localized empty hydrogels gelled successfully around host vessel with required shape. Implantations of cell encapsulated hydrogels and histological analyses are under study. It is expected that endothelial cells inside the hydrogel will form a capillary network and they will bind to the host vessel passing through hydrogel. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adipose%20tissue%20engineering" title="adipose tissue engineering">adipose tissue engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=decellularization" title=" decellularization"> decellularization</a>, <a href="https://publications.waset.org/abstracts/search?q=encapsulation" title=" encapsulation"> encapsulation</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=vascularization" title=" vascularization"> vascularization</a> </p> <a href="https://publications.waset.org/abstracts/19805/vascularized-adipose-tissue-engineering-by-using-adipose-ecmfibroin-hydrogel" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19805.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">528</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">132</span> Development of a Myocardial Patch with 3D Hydrogel Electrical Stimulation System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yung-Gi%20Chen">Yung-Gi Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Pei-Leun%20Kang"> Pei-Leun Kang</a>, <a href="https://publications.waset.org/abstracts/search?q=Yu-Hsin%20Lin"> Yu-Hsin Lin</a>, <a href="https://publications.waset.org/abstracts/search?q=Shwu-Jen%20Chang"> Shwu-Jen Chang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Myocardial tissue has limited self-repair ability due to its loss of differentiation characteristic for most mature cardiomyocytes. Therefore, the effective use of stem cell technology in regenerative medicine is an important development to alleviate the current difficulties in cardiac disease treatment. The main purpose of this project was to develop a 3-D hydrogel electrical stimulating system for promoting the differentiation of stem cells into myocardial cells, and the patch will be used to repair damaged myocardial tissue. This project was focused on the preparation of the electrical stimulation system with carbon/CaCl₂ electrodes covered with carbon nanotube-hydrogel. In this study, we utilized screen imprinting techniques and used Poly(lactic-co-glycolic acid)(PLGA) membranes as printing substrates to fabricate a carbon/CaCl₂ interdigitated electrode that covered with alginate/carbon nanotube hydrogels. The single-walled carbon nanotube was added in the hydrogel to enhance the mechanical strength and conductivity of hydrogel. In this study, we used PLGA (85:15) as electrode preparing substrate. The CaCl₂/ EtOH solution (80% w/v) was mixed into carbon paste to prepare various concentration calcium-containing carbon paste (2.5%, 5%, 7.5%, 10% v/v). Different concentrations of alginate (1%, 1.5%, 2% v/v) and SWCNT(Diameter < 2nm, length between 5-15μm) (1, 1.5, 3 mg/ml) are gently immobilized on the electrode by cross-linking with calcium chloride. The three-dimensional hydrogel electrode was tested for its redox efficiency by cyclic voltammetry to determine the optimal parameters for the hydrogel electrode preparation. From the result of the final electrodes, it indicated that the electrode was not easy to maintain the pattern of the interdigitated electrode when the concentration of calcium of chloride was more than 10%. According to the gel rate test and cyclic voltammetry experiment results showed the SWCNT could increase the electron conduction of hydrogel electrodes significantly. So far the 3D electrode system has been completed, 2% alginate mixed with 3mg SWCNT is the optimal condition to construct the most complete structure for the hydrogel preparation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=myocardial%20tissue%20engineering" title="myocardial tissue engineering">myocardial tissue engineering</a>, <a href="https://publications.waset.org/abstracts/search?q=screen%20printing%20technology" title=" screen printing technology"> screen printing technology</a>, <a href="https://publications.waset.org/abstracts/search?q=poly%20%28lactic-co-glycolic%20acid%29" title=" poly (lactic-co-glycolic acid)"> poly (lactic-co-glycolic acid)</a>, <a href="https://publications.waset.org/abstracts/search?q=alginate" title=" alginate"> alginate</a>, <a href="https://publications.waset.org/abstracts/search?q=single%20walled%20carbon%20nanotube" title=" single walled carbon nanotube"> single walled carbon nanotube</a> </p> <a href="https://publications.waset.org/abstracts/98452/development-of-a-myocardial-patch-with-3d-hydrogel-electrical-stimulation-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/98452.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">113</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=hydrogel&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=hydrogel&page=3">3</a></li> <li class="page-item"><a class="page-link" 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