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Steers,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-2"> Yifu Li,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-3"> Elena Sanchez-Rodriguez,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-4"> Miguel Verbitsky,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-5"> Isabel Robbins,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-6"> Jenna Simpson,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-7"> Sharvari Pathak,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-8"> Milan Raska,2 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-9"> Colin Reily,2 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-10"> Anna Ng,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-11"> Judy Liang,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-12"> Natalia DeMaria,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-13"> Amanda Katiraei,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-14"> Kelsey O'Stevens,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-15"> Clara Fischman,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-16"> Samantha Shapiro,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-17"> Swetha Kodali,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-18"> Jason McCutchan,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-19"> Heekuk Park,4 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-20"> Djamila Eliby,4 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-21"> Marco Delsante,5 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-22"> Landino Allegri,5 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-23"> Enrico Fiaccadori,5 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-24"> Monica Bodria,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-25"> Maddalena Marasa,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-26"> Elizabeth Raveche,7 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-27"> Bruce A. Julian,8 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-28"> Anne-Catrin Uhlemann,4 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-29"> Krzysztof Kiryluk,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-30"> Hong Zhang,9 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-31"> Vivette D. D'Agati,10 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-32"> Simone Sanna-Cherchi,1 </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-33"> Jan Novak,11 and </a> <a class="author-affiliation show-more" href="javascript:void(0);" data-dropdown="author-affiliation-34"> Ali G. Gharavi1 </a> </h4> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-0"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Prakash, S. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Sindhuri%22+author.last_name%3A%22Prakash%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Prakash+S[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AS+Prakash%22" >Google Scholar </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-1"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Steers, N. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Nicholas J.%22+author.last_name%3A%22Steers%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Steers+N[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AN+Steers%22" >Google Scholar </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-2"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Li, Y. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Yifu%22+author.last_name%3A%22Li%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Li+Y[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AY+Li%22" >Google Scholar </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-3"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Sanchez-Rodriguez, E. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Elena%22+author.last_name%3A%22Sanchez-Rodriguez%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Sanchez-Rodriguez+E[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AE+Sanchez-Rodriguez%22" >Google Scholar </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-4"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Verbitsky, M. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Miguel%22+author.last_name%3A%22Verbitsky%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Verbitsky+M[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AM+Verbitsky%22" >Google Scholar </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-5"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Robbins, I. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Isabel%22+author.last_name%3A%22Robbins%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Robbins+I[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AI+Robbins%22" >Google Scholar </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-6"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Simpson, J. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Jenna%22+author.last_name%3A%22Simpson%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Simpson+J[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AJ+Simpson%22" >Google Scholar </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-7"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Pathak, S. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Sharvari%22+author.last_name%3A%22Pathak%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Pathak+S[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AS+Pathak%22" >Google Scholar </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-8"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of 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Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Reily, C. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Colin%22+author.last_name%3A%22Reily%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Reily+C[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AC+Reily%22" >Google Scholar </a> </div> <div class="f-dropdown content 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Birmingham, United States of America Find articles by Ng, A. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Anna%22+author.last_name%3A%22Ng%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Ng+A[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AA+Ng%22" >Google Scholar </a> | <a target="_blank" href=https://orcid.org/0000-0002-3902-4769 ><img src="/assets/orcid_24x24-c3dd8466870e6d6844746d0390885a978817f110ed6b16957bc1ad3a282af054.png" /> </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-11"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Liang, J. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Judy%22+author.last_name%3A%22Liang%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Liang+J[au]&dispmax=50" >PubMed </a> | <a 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University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Katiraei, A. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Amanda%22+author.last_name%3A%22Katiraei%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Katiraei+A[au]&dispmax=50" >PubMed </a> | <a target="_blank" 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University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Fischman, C. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Clara%22+author.last_name%3A%22Fischman%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Fischman+C[au]&dispmax=50" >PubMed </a> | <a target="_blank" 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University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Kodali, S. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Swetha%22+author.last_name%3A%22Kodali%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Kodali+S[au]&dispmax=50" >PubMed </a> | <a target="_blank" 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University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Park, H. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Heekuk%22+author.last_name%3A%22Park%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Park+H[au]&dispmax=50" >PubMed </a> | <a target="_blank" 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York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Delsante, M. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Marco%22+author.last_name%3A%22Delsante%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Delsante+M[au]&dispmax=50" >PubMed </a> | <a target="_blank" 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University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Fiaccadori, E. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Enrico%22+author.last_name%3A%22Fiaccadori%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Fiaccadori+E[au]&dispmax=50" >PubMed </a> | <a target="_blank" 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University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Bodria, M. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Monica%22+author.last_name%3A%22Bodria%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Bodria+M[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AM+Bodria%22" >Google Scholar </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-25"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Marasa, M. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Maddalena%22+author.last_name%3A%22Marasa%22&search_type=advanced" >JCI </a> | <a 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Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Julian, B. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Bruce A.%22+author.last_name%3A%22Julian%22&search_type=advanced" >JCI </a> | <a 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Find articles by Kiryluk, K. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Krzysztof%22+author.last_name%3A%22Kiryluk%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Kiryluk+K[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AK+Kiryluk%22" >Google Scholar </a> | <a target="_blank" href=https://orcid.org/0000-0002-5047-6715 ><img src="/assets/orcid_24x24-c3dd8466870e6d6844746d0390885a978817f110ed6b16957bc1ad3a282af054.png" /> </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-30"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Zhang, H. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Hong%22+author.last_name%3A%22Zhang%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Zhang+H[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AH+Zhang%22" >Google Scholar </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-31"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by D'Agati, V. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Vivette D.%22+author.last_name%3A%22D'Agati%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=D'Agati+V[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AV+D'Agati%22" >Google Scholar </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-32"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Sanna-Cherchi, S. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Simone%22+author.last_name%3A%22Sanna-Cherchi%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Sanna-Cherchi+S[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AS+Sanna-Cherchi%22" >Google Scholar </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-33"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Novak, J. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Jan%22+author.last_name%3A%22Novak%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Novak+J[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AJ+Novak%22" >Google Scholar </a> </div> <div class="f-dropdown content large" data-dropdown-content id="author-affiliation-34"> 1Division of Nephrology, Columbia University, New York, United States of America2Department of Immunology, University of Alabama at Birmingham, Birmingham, Czech Republic3Department of Immunology, University of Alabama at Birmingham, Birmingham, United States of America4Division of Infectious Diseases, Columbia University, New York, United States of America5Departments of Medicine and Surgery, University of Parma, Parma, Italy6Division of Nephrology, Columbia University, New York, Italy7Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, United States of America8Division of Nephrology, University of Alabama at Birmingham, Birmingham, United States of America9The Renal Division, Peking University First Hospital, Beijing, China10Division of Renal Pathology, Columbia University, New York, United States of America11Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States of America Find articles by Gharavi, A. in: <a target="_blank" href="/search/results?q=author.first_name%3A%22Ali G.%22+author.last_name%3A%22Gharavi%22&search_type=advanced" >JCI </a> | <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term=Gharavi+A[au]&dispmax=50" >PubMed </a> | <a target="_blank" href="http://scholar.google.com/scholar?q=%22author%3AA+Gharavi%22" >Google Scholar </a> | <a target="_blank" href=https://orcid.org/0000-0003-2801-233X ><img src="/assets/orcid_24x24-c3dd8466870e6d6844746d0390885a978817f110ed6b16957bc1ad3a282af054.png" /> </a> </div> Published March 28, 2025 - <a class='show-more' data-dropdown='full-publication-dropdown' href='javascript:void(0);'> More info </a> <div class='f-dropdown content large' data-dropdown-content='' id='full-publication-dropdown'> <div class='copyright'> J Clin Invest. <a href="https://doi.org/10.1172/JCI181164">https://doi.org/10.1172/JCI181164</a>. Copyright 漏 2025, Prakash et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. </div> <div class='publication_date'> Published March 28, 2025 - <a href="#version_history">Version history</a> </div> </div> <a href="/articles/view/181164/pdf">View PDF <img class="article-tools-icon" src="//dm5migu4zj3pb.cloudfront.net/images/adobe_pdf_file_icon.png" /></a> <div class="content_well"> <a class="in-page" name="ABS"></a><dl class="article-section" data-accordion=""><dd class="accordion-navigation active"> <a href="#section-abstract">Abstract</a><div id="section-abstract" class="content active">Aberrant O-glycosylation of the IgA1 hinge region is a characteristic finding in patients with IgA nephropathy (IgAN) and is thought to contribute to immune-complex formation and kidney injury. Other studies have suggested that abnormalities in mucosal immunity and lymphocyte homing are major contributors to disease. We identified a family with IgAN segregating a heterozygous predicted loss-of-function (LOF) variant in GALNT14, the gene encoding N-acetylgalactosaminyltransferase 14, one of the enzymes involved in mucin-type protein O-glycosylation. While GALNT14 is expressed in IgA1-producing cells, carriers of the LOF variant did not have altered levels of poorly glycosylated IgA1, suggesting other disease mechanisms. Investigation of Galnt14 null mice revealed elevated serum IgA levels and ex vivo IgA production by B cells. These mice developed glomerular IgA deposition with aging and after induction of sterile colitis. Galnt14 null mice also displayed an attenuated mucin layer in the colon and redistribution of IgA-producing cells from mucosal to systemic sites. Adoptive-transfer experiments indicated impaired homing of spleen-derived Galnt14 deficient B lymphocytes, resulting in increased retention in peripheral blood. These findings suggest that abnormalities in O-glycosylation alter mucosal immunity and B lymphocyte homing, pointing to an expanded role of aberrant O-glycosylation in the pathogenesis of IgAN.</div> </dd></dl> <a class="in-page" name="GRABS"></a><dl class="article-section" data-accordion=""><dd class="accordion-navigation active"> <a href="#section-graphical-abstract">Graphical Abstract</a><div id="section-graphical-abstract" class="content active"><a href="/articles/view/181164/ga"><img alt="graphical abstract" title="Graphical abstract" src="//dm5migu4zj3pb.cloudfront.net/manuscripts/181000/181164/medium/181164-JCI-RG-RV-3_ga_870606.jpg"></a></div> </dd></dl> <a class="in-page" name="sd"></a><dl class="article-section" data-accordion=""><dd class="accordion-navigation active"> <a href="#supplemental-material">Supplemental material</a><div id="supplemental-material" class="content active"><a href="/articles/view/181164/sd/1"> View </a></div> </dd></dl> </div> <dl class='article-section' data-accordion> <dd class='accordion-navigation active'> <a href='#version_history'> Version history </a> <div class='content active' id='version_history'> <ul> <li> Version 1 (March 28, 2025): In-Press Preview </li> </ul> </div> </dd> </dl> </div> <div class="large-3 columns show-for-large-up"> <div id='sidebar-container'> <div id='sidebar'> <div class='non-sticky-content'> <h4 class='subheader'>Article tools</h4> <ul class='side-nav' id='article-tools'> <li class='hide-for-small'> <a href="/articles/view/181164/pdf">View PDF <img class="article-tools-icon" src="//dm5migu4zj3pb.cloudfront.net/images/adobe_pdf_file_icon.png" /></a> </li> <li><a href="/articles/view/181164/cite">Download citation information</a></li> <li><a href="/eletters/submit/181164">Send a comment</a></li> <li><a href="/kiosks/terms">Terms of use</a></li> <li><a href="/kiosks/publish/abbreviations">Standard abbreviations</a></li> <li><a href="/feedback?reference=181164">Need help? Email the journal</a></li> <script> var addthis_share = { email_template: 'jci_share_article', email_vars: { short_title: 'Loss of GalNAc-T14 links O-glycosylation defects to...', author_list: 'Sindhuri Prakash, Nicholas J. Steers, Yifu Li, Elena Sanchez-Rodriguez, Miguel Verbitsky, Isabel Robbins, Jenna Simpson, Sharvari Pathak, Milan Raska, Colin Reily, Anna Ng, Judy Liang, Natalia DeMaria, Amanda Katiraei, Kelsey O'Stevens, Clara Fischman, Samantha Shapiro, Swetha Kodali, Jason McCutchan, Heekuk Park, Djamila Eliby, Marco Delsante, Landino Allegri, Enrico Fiaccadori, Monica Bodria, Maddalena Marasa, Elizabeth Raveche, Bruce A. Julian, Anne-Catrin Uhlemann, Krzysztof Kiryluk, Hong Zhang, Vivette D. D'Agati, Simone Sanna-Cherchi, Jan Novak, Ali G. Gharavi', } } </script> <div class="addthis_sharing_toolbox" data-title="JCI - Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy"></div> </ul> <h4 class='subheader'>Metrics</h4> <div class='altmetric-embed centered' data-badge-popover='left' data-badge-type='medium-donut' data-doi='10.1172/JCI181164'></div> <ul class='side-nav' id='article-metrics'> <li><a href="/articles/view/181164/usage">Article usage</a></li> <li> <a href="/articles/view/181164/citations">Citations to this article </a></li> </ul> </div> <div class='sticky-content'> <h4 class='subheader'>Go to</h4> <div id='goto'> <ul class='side-nav'> <li><a href="#top">Top</a></li> <li><a href="#ABS">Abstract</a></li> <li><a href="#sd">Supplemental material</a></li> <li><a href="#version_history">Version history</a></li> </ul> </div> </div> </div> </div> </div> </div> <div class="row hide-for-small"> <div class="medium-12 columns"> <div style='width:100%; text-align: center;'> <div id='jci-article-interior-leaderboard-bottom'> Advertisement <script> try { googletag.cmd.push(function() { googletag.display('jci-article-interior-leaderboard-bottom'); }) } catch(e){} </script> </div> </div> </div> </div> </div> <div class='large-2 medium-3 hide-for-small columns' style='padding: 12px 9px 12px 9px;'> <div style='width:100%; text-align: center;'> <div class='ad-interior-r-sideboard' id='jci-article-interior-skyscraper-right-col'> Advertisement <script> try { googletag.cmd.push(function() { googletag.display('jci-article-interior-skyscraper-right-col'); }) } catch(e){} </script> </div> </div> </div> </div> </div> </div> </div> </div> <div id='footer'> <div class='row panel-padding'> <div class='small-6 columns'> <div id='social-links'> <a onclick="trackOutboundLink('/twitter?ref=footer');" href="/twitter"><img title="Twitter" src="/assets/social/twitter-round-blue-78025a92064e3594e44e4ccf5446aefeafba696cd3c8e4a7be1850c7c9f62aba.png" /></a> <a onclick="trackOutboundLink('/facebook?ref=footer');" href="/facebook"><img title="Facebook" src="/assets/social/facebook-round-blue-2787910d46dcbdbee4bd34030fee044e5a77cfda2221af9191d437b2f5fadeb1.png" /></a> <a href="/rss"><img title="RSS" src="/assets/social/rss-round-color-6f5fa8e93dc066ee4923a36ba6a7cb97d53c5b77de78a2c7b2a721adc603f342.png" /></a> </div> Copyright © 2025 <a href="http://www.the-asci.org">American Society for Clinical Investigation</a> ISSN: 0021-9738 (print), 1558-8238 (online) </div> <div class='small-6 columns'> <div class='row'> <div class='small-12 columns'> <h4 class='notices-signup'>Sign up for email alerts</h4> <form action='https://notices.jci.org/subscribers/new' method='get'> <input name='utm_source' type='hidden' value='jci'> <input name='utm_medium' type='hidden' value='web'> <input name='utm_campaign' type='hidden' value='email_signup'> <input name='utm_content' type='hidden' value='footer'> <div class='row'> <div class='small-12 medium-9 columns'> <input name='email_address' placeholder='Your email address' required type='text'> </div> <div class='small-12 medium-3 columns'> <input class='button tiny orange' type='submit' value='Sign up'> </div> </div> </form> </div> </div> </div> </div> </div> </div> <script src="/assets/application-27f18b5fe3b7302e5b3e3c6d7cf9bb3f54759fad32679209f5aef429b89f3aef.js"></script>  <script src="//s7.addthis.com/js/300/addthis_widget.js#pubid=ra-4d8389db4b0bb592" async="async"></script> <script src="//d1bxh8uas1mnw7.cloudfront.net/assets/embed.js" async="async"></script> <script type="text/javascript"> jQuery(document).ready(function() { ArticleStickyNav.init(); display_citation_count(181164); setMaxGaSize(jQuery('div.inner-wrap .fixed.show-for-large-up'), jQuery('div#section-graphical-abstract img')); }); </script>  </body> </html>