Recently closed trials : University College London Hospitals NHS Foundation Trust

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href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/goodybe-and-good-luck-dr-seddon" target="_self" class="nav-item " tabindex="-1">Goodbye and Good Luck Dr Seddon!</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/sarcoma-awareness-month-2023" target="_self" class="nav-item " tabindex="-1">SARCOMA AWARENESS MONTH 2023</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/congratulations-professor-strauss" target="_self" class="nav-item " tabindex="-1">Congratulations Professor Strauss!</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/sarcoma-awareness-month-team-picnic" target="_self" class="nav-item " tabindex="-1">Sarcoma Awareness Month Team Picnic</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/rnoh-cuppa-and-cake-event-raises-428" target="_self" class="nav-item " tabindex="-1">RNOH Cuppa and Cake Event raises £428</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/sarcoma-awareness-month-stall" target="_self" class="nav-item " tabindex="-1">Sarcoma Awareness Month Stall</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/london-sarcoma-strategy-day" target="_self" class="nav-item " tabindex="-1">The London Sarcoma Strategy Day</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/rnoh-wins-noa-awards-2023" target="_self" class="nav-item " tabindex="-1">RNOH wins at NOA Awards 2023!</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/new-soft-tissue-sarcoma-hub-and-spoke-services-london" target="_self" class="nav-item " tabindex="-1">New hub and spoke GP urgent referral process for adult soft tissue sarcoma</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/ctos-dublin-2023" target="_self" class="nav-item " tabindex="-1">CTOS Dublin 2023</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/london-sarcoma-support-group" target="_self" class="nav-item " tabindex="-1">London Sarcoma Support Group</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/congratulations-anne-mctiernan-winning-sarcoma-uks-inaugural-shining-star-award" target="_self" class="nav-item " tabindex="-1">Congratulations to Anne McTiernan and Jo Coleman on winning Sarcoma UK’s inaugural Shining Star award</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/congratulations-mr-vasilios-karavasilis" target="_self" class="nav-item " tabindex="-1">Congratulations Dr Vasilios Karavasilis</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/fundraising-rare-cancer" target="_self" class="nav-item " tabindex="-1">Fundraising for RARE Cancer</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/surgeon-year" target="_self" class="nav-item " tabindex="-1">Surgeon of the Year</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/wood-green-community-diagnostic-centre-prior-suspected-cancer-referral" target="_self" class="nav-item " tabindex="-1">Wood Green Community Diagnostic Centre (prior to a suspected cancer referral)</a> </div></li><li class="nav-last level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/additional-sarcoma-diagnostic-spoke-goes-live-barts-health" target="_self" class="nav-item nav-last " tabindex="-1">Additional Sarcoma diagnostic ‘spoke’ goes live at Bart’s Health</a> </div></li></ul></div></div></li><li class="nav-dropdown hidden-md hidden-lg level-1 contact_us"><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/contact-us" target="_self" class="nav-item nav-dropdown hidden-md hidden-lg " aria-haspopup="true">Contact us</a> <button class="sub-button" title="Open Contact us submenu" aria-label="Contact us submenu" type="button" aria-expanded="false"><span></span></button><div class="sub-menu nav-dropdown hidden-md hidden-lg level-2"><ul class="sub-menu-list"><li class="nav-dropdown-title hidden-md hidden-lg"><div class="item-wrapper"><button title="Return to previous menu" aria-label="Return to previous menu" class="back-button" type="button"><span></span></button><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/contact-us" aria-hidden="true" tabindex="-1">Contact us</a></div></li><li class="nav-first hidden-md hidden-lg level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/contact-us/royal-national-orthopaedic-hospital" target="_self" class="nav-item nav-first hidden-md hidden-lg " tabindex="-1">Royal National Orthopaedic Hospital</a> </div></li><li class="nav-last hidden-md hidden-lg level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/contact-us/university-college-london-hospital" target="_self" class="nav-item nav-last hidden-md hidden-lg " tabindex="-1">University College London Hospital</a> </div></li></ul></div></div></li><li class="nav-dropdown level-1 sarcoma_patients"><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients" target="_self" class="nav-item nav-dropdown " aria-haspopup="true">Sarcoma patients</a> <button class="sub-button" title="Open Sarcoma patients submenu" aria-label="Sarcoma patients submenu" type="button" aria-expanded="false"><span></span></button><div class="sub-menu nav-dropdown level-2"><ul class="sub-menu-list"><li class="nav-dropdown-title hidden-md hidden-lg"><div class="item-wrapper"><button title="Return to previous menu" aria-label="Return to previous menu" class="back-button" type="button"><span></span></button><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients" aria-hidden="true" tabindex="-1">Sarcoma patients</a></div></li><li class="nav-first level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/what-sarcoma" target="_self" class="nav-item nav-first " tabindex="-1">What is sarcoma?</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/diagnosing-sarcoma" target="_self" class="nav-item " tabindex="-1">Diagnosing sarcoma</a> </div></li><li class="nav-dropdown level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/treating-sarcoma" target="_self" class="nav-item nav-dropdown " tabindex="-1">Treating sarcoma</a> <button class="sub-button" title="Open Treating sarcoma submenu" aria-label="Treating sarcoma submenu" type="button" aria-expanded="false"><span></span></button><div class="sub-menu nav-dropdown level-3"><ul class="sub-menu-list"><li class="nav-dropdown-title hidden-md hidden-lg"><div class="item-wrapper"><button title="Return to previous menu" aria-label="Return to previous menu" class="back-button" type="button"><span></span></button><a 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href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/treating-sarcoma/palliative-care" target="_self" class="nav-item hidden-md hidden-lg " tabindex="-1">Palliative Care</a> </div></li><li class="nav-last hidden-md hidden-lg level-3 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/treating-sarcoma/proton-beam-therapy-pbt" target="_self" class="nav-item nav-last hidden-md hidden-lg " tabindex="-1">Proton Beam Therapy (PBT)</a> </div></li></ul></div></div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/follow" target="_self" class="nav-item " tabindex="-1">Follow Up</a> </div></li><li class="nav-dropdown level-2 "><div class="item-wrapper"><a 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nav-last hidden-md hidden-lg " tabindex="-1">Rehabilitation at RNOH</a> </div></li></ul></div></div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/support-services" target="_self" class="nav-item " tabindex="-1">Support Services</a> </div></li><li class="nav-dropdown level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/patient-information" target="_self" class="nav-item nav-dropdown " tabindex="-1">Patient Information</a> <button class="sub-button" title="Open Patient Information submenu" aria-label="Patient Information submenu" type="button" aria-expanded="false"><span></span></button><div class="sub-menu nav-dropdown level-3"><ul class="sub-menu-list"><li class="nav-dropdown-title hidden-md hidden-lg"><div class="item-wrapper"><button title="Return to previous menu" aria-label="Return to previous menu" class="back-button" type="button"><span></span></button><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/patient-information" aria-hidden="true" tabindex="-1">Patient Information</a></div></li><li class="nav-first hidden-md hidden-lg level-3 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/patient-information/rnoh-leaflets-and-videos" target="_self" class="nav-item nav-first hidden-md hidden-lg " tabindex="-1">RNOH leaflets and videos</a> </div></li><li class="hidden-md hidden-lg level-3 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/patient-information/uclh-information-and-videos" target="_self" class="nav-item hidden-md hidden-lg " tabindex="-1">UCLH information and videos</a> </div></li><li 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class="sidebar-list"> <li class=" "> <a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-research/clinical-trials/currently-open-trials" target="_self" >Currently open trials</a> </li> <li class="active "> <a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-research/clinical-trials/recently-closed-trials" target="_self" >Recently closed trials</a> </li> </ul> </div> </div> </div> </div> </div> </div> <div class="col-md-17"> <div class="main-content-column"> <div class="content-wrapper"> <div class="core-style"> <div class="content-block clearfix"> <p><strong><a href="https://sarcoma.org.uk/research/clinical-trials/afatinib-locally-advanced-and-metastatic-chordoma" target="_blank" data-link_text="AFATINIB FOR CHORDOMA:">AFATINIB FOR CHORDOMA:</a> </strong>A phase II, single arm, multi-centre trial evaluating the efficacy of Afatinib as first-line or later-line treatment in metastatic or unresectable chordoma</p> <p><strong>Brightline-1</strong>: A Phase II/III, Open-label, Multi-center, Randomized Study of BI 907828 Compared to Doxorubicin in the First Line Treatment of Patients with Dedifferentiated Liposarcoma</p> <p><strong><u>DeFI Study:</u> </strong>A randomized, double-blind, placebo-controlled, phase III trial of Nirogacestat versus placebo in adult patients with progressing desmoid tumours/aggressive fibromatosis</p> <p><a href="https://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-trial-looking-at-niraparib-with-temozolomide-or-irinotecan-for-ewings-sarcoma-that-has-come-back?_ga=2.109274437.1701731034.1554391402-1456959764.1462542222" data-link_text="ESPRIT"><strong>ESPRIT</strong></a>: ESP1/SARC025 Global Collaboration: A phase I study of a combination of the PARP inhibitor, Niraparib and Temozolomide or Irinotecan in patients with previously treated, incurable Ewing sarcoma</p> <p style="text-align:justify"><strong><u>E7389-G000-213 (BOLD):</u></strong> A phase I/II single-arm study evaluating the safety and efficacy of Eribulin Mesilate in combination with Irinotecan in children with refractory or recurrent solid tumours</p> <p style="text-align:justify"><strong><u>E7080-G000-230 (OLIE):</u> </strong>A multicenter, open-label, randomized phase II study to compare the efficacy and safety of Lenvatinib in combination with Ifosfamide and Etoposide versus Ifosfamide and Etoposide in children, adolescents and young adults with relapsed or refractory Osteosarcoma</p> <p><strong><u><a href="https://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-trial-cabozantinib-chemotherapy-sarcoma-womb-spread-cant-removed-operation-hgus-study?_ga=2.78693844.1701731034.1554391402-1456959764.1462542222" target="_blank" data-link_text="HGUS EORTC 62113">HGUS EORTC 62113</a>:</u></strong> A randomised double-blind phase II study evaluating the role of maintenance Cabozantinib in high grade undifferentiated uterine sarcoma (HGUS) or response to Doxorubicin +/-Ifosfamide or in metastatic first line treatment</p> <p><strong><a href="https://sarcoma.org.uk/research/clinical-trials/study-ramucirumab-children-and-young-adults-synovial-sarcoma" target="_blank" data-link_text="J1S-MC-JV02:">J1S-MC-JV02:</a></strong> Protocol Addendum J1S-MC-JV02(a) A Randomized, Open-Label Phase 2 Study Evaluating Ramucirumab in Pediatric Patients and Young Adults with Relapsed, Recurrent, or Refractory Synovial Sarcoma</p> <p><strong><u><a href="https://sarcoma.org.uk/research/clinical-trials/study-ramucirumab-children-and-young-adults-desmoplastic-small-round-cell" data-link_text="J1S-MC-JV01:">J1S-MC-JV01:</a></u></strong> Protocol Addendum J1S-MC-JV01(a) A Randomized, Open-Label Phase 2 Study Evaluating Ramucirumab in Pediatric Patients and Young Adults with Relapsed, Recurrent, or Refractory Desmoplastic Small Round Cell Tumor</p> <p><strong><a href="https://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-trial-of-imrt-to-treat-bone-and-soft-tissue-sarcoma-imris?_ga=2.146367860.1701731034.1554391402-1456959764.1462542222" target="_blank" data-link_text="IMRIS">IMRIS</a>: </strong>A phase II study of intensity modulated radiotherapy (IMRT) in primary bone and soft tissue sarcoma</p> <p><strong>INTRIGUE:</strong> A phase III, interventional, randomised, multicentre, open-label study of DCC-2618 vs sunitinib in patients with advanced gastrointestinal stromal tumours after treatment with imatinib</p> <p><strong><a href="https://sarcoma.org.uk/research/funded-projects/international-sarcoma-kindred-study-global-multi-site-prospective-cancer" target="_blank" data-link_text="Kindred Study:">Kindred Study:</a> </strong>The international sarcoma kindred study: a global multi-site prospective cancer genetics study</p> <p style="text-align:justify"><strong><u>KCP-330-020 (SEAL</u>): </strong>A phase II/III multicentre, randomised, double-blind study of Selinexor (KPT - 330) verus placebo in patient with advanced unresectable differentiated liposarcoma</p> <p style="text-align:justify"><strong><u>RAPPER:</u></strong> Radiogenomics: Assessment of polymorphisms for predicting the effects of radiotherapy</p> <p style="text-align:justify"><strong><a href="https://www.eortc.org/research_field/clinical-detail/1762/" target="_blank" data-link_text="REDUCE (EORTC 1762):">REDUCE (EORTC 1762):</a> </strong>Reduced dose-density of denosumab for maintenance therapy of unresectable giant cell tumour of bone: a multicentre phase II study</p> <p><strong><u>MOTION:</u></strong> A Phase 3, Randomized, Placebo-controlled, Double-blind Study of Vimseltinib to Assess the Efficacy and Safety in Patients with Tenosynovial Giant Cell Tumor (MOTION)</p> <p><a href="https://sarcoma.org.uk/research/clinical-trials/ssg-xxii" data-link_text="SSG XXII:"><strong>SSG XXII</strong>:</a> A phase III prospective, multi-centre, open-label, 2 arm study for evaluation of 2 durations of adjuvant treatment with the tyrosine kinase inhibitor Imastinib Mesylate of operable gastrointestinal stromal cells tumour (GIST) with a high risk for recurrence</p> <p> </p> </div> </div> </div> </div> </div> <div class="col-md-7"> <div class="sidebar-wrapper"> <div class="sidebar sidebar-plain"> <div class="core-style"> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/what-sarcoma" target="_self" aria-label="What is sarcoma?"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/2116/0630/6586/Icon1.png" alt=""> </div> <div class="box-title"> <p>What is sarcoma?</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/diagnosing-sarcoma" target="_self" aria-label="Diagnosing sarcoma"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/9516/0630/6596/LSdiag.png" alt=""> </div> <div class="box-title"> <p>Diagnosing sarcoma</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/treating-sarcoma" target="_self" aria-label="Treating sarcoma"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/5316/0630/6596/LStreat.png" alt=""> </div> <div class="box-title"> <p>Treating sarcoma</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/rehabilitation-and-support-services" target="_self" aria-label="Rehabilitation"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/2116/0630/6596/LSrehab.png" alt=""> </div> <div class="box-title"> <p>Rehabilitation and support services</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-referrals" target="_self" aria-label="Sarcoma referrals"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/6516/0562/3089/BDrefericon.png" alt=""> </div> <div class="box-title"> <p>Sarcoma referrals</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/our-sarcoma-teams" target="_self" aria-label="Sarcoma teams"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/8316/0630/6596/LSteam.png" alt=""> </div> <div class="box-title"> <p>Meet the sarcoma teams</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-research" target="_self" aria-label="Sarcoma research and innovation"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/9316/0630/6596/LSresearch.png" alt=""> </div> <div class="box-title"> <p>Sarcoma research</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" 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Recently closed trials : University College London Hospitals NHS Foundation Trust