UC Davis Health is first in the region to launch unique bladder cancer clinical trial

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id="sectionkmxfk96x"> <div class="row iw_row iw_stretch" id="rowkmxfk96y"> <div class="iw_columns col-lg-12" id="colkmxfk96z"> <div class="iw_placeholder" id="iw_placeholder1617194016392"> <div class="iw_component" id="iw_comp1636036914496"> <style>#iw_comp1636036914496{}</style><div class="page-content-breadcrumbs wrapper d-flex justify-content-center mb-7"> <div class="sizer col-12"> <nav aria-label="breadcrumb"> <ol class="breadcrumb"> <li class="breadcrumb-item"><a id="news-post-global-pagebreadcrumbfirstlevel" href="/welcome/" title="UC Davis Health">UC Davis Health</a></li> <li class="breadcrumb-item"><a id="news-post-site-pagebreadcrumbfirstlevel" href="/news/" title="News">News</a></li> <li class="breadcrumb-item"><a id="news-post-listing-url" href="/news/headlines/" title="Headlines">Headlines</a></li> <li class="breadcrumb-item active" aria-current="page">UC Davis Health is first in the region ... </li> </ol> </nav> </div> </div><div class="news-article-container marquee-small nosummary"> <div class="jumbotron jumbotron-fluid hero"> <div class="hero-image-container article-feature-img body-width"><picture> <source media="(min-width:576px)" srcset="/media-resources/contenthub/health-news/2024/11/marquee/urinary-system-sm.jpg"><img class="img-fluid" width="730" height="345" src="/media-resources/contenthub/health-news/2024/11/thumbnail/urinary-system-th.jpg" alt="Urinary system"></picture></div> </div> <article id="content" class="news-article"> <div class="wrapper d-flex justify-content-center"> <div class="sizer col-lg-10 mb-5 mb-md-7"> <div class="article-container news-post row dflex justify-content-center mx-0"> <header xmlns:xs="http://www.w3.org/2001/XMLSchema" id="article-header" class="article-header sizer col-lg-10"> <div class="article-dateline-wrapper"><a class="category" href="/news/topic/cancer">Cancer Care</a><span class="dateline">November 22, 2024</span></div> <h1 class="article-title">UC Davis Health is first in the region to launch unique bladder cancer clinical trial</h1><span class="byline">By <span class="author-1">Stephanie Winn</span></span></header> <h2 class="mb-3 col-lg-10 lede">Groundbreaking study uses immunotherapy created from a specially engineered virus</h2> <div xmlns:xs="http://www.w3.org/2001/XMLSchema" class="article-body sizer col-lg-10"><strong class="story-location mr-2">(SACRAMENTO) </strong><p><a href="https://health.ucdavis.edu/cancer/">UC Davis Comprehensive Cancer Center</a> is the first in the region to offer a new groundbreaking clinical trial for bladder cancer patients. Previously, about 70% of these patients could only “watch and wait” and hope their cancer did not return.</p> <figure class="image img-right"><img src="/media-resources/contenthub/health-news/2024/11/body/BladderCancer-b.jpg" width="450" height="241" alt="Bladder cancer graphic" /></figure> <p>The innovative treatment could reduce the significant stress experienced by patients who have intermediate-risk <a href="https://bcan.org/what-is-non-muscle-invasive-bladder-cancer/?gad_source=1&gclid=Cj0KCQiAoae5BhCNARIsADVLzZdSVcB3z0H2N63qwe7rFcxLqBJsIo6b_eweqDujEx8yzWQM5Mh1oscaAuDdEALw_wcB">non-muscle invasive bladder cancer</a> (IR-NMIBC) by increasing their options for treatments that preserve the bladder.</p> <p>Many of these bladder cancer patients will see their cancer return, even after a <a href="https://bcan.org/bladder-cancer-TURBT/">transurethral resection of the bladder tumor</a> surgery to remove cancerous cells.</p> <p>Monitoring for any recurrence of cancer means patients must undergo routine <a href="https://www.cancer.org/cancer/diagnosis-staging/tests/endoscopy/cystoscopy.html">cystoscopy</a>. This involves inserting a tube into the urethra and bladder every 3-6 months to check for cancerous tumors.</p> <h2>Specially engineered virus trained to kill cancer cells</h2> <p>UC Davis is one of a handful of sites across the country trying something new for bladder cancer patients. The <a href="https://cgoncology.com/pivot-006/">PIVOT-006</a> clinical trial will test the effectiveness of <a href="https://www.cancer.gov/publications/dictionaries/cancer-drug/def/cretostimogene-grenadenorepvec">Cretostimogene Grenadenorepvec</a> (Cretostimogene) with IR-NMIBC patients.</p> <p>Cretostimogene is a laboratory-altered virus designed to target and kill cancer cells. It is unique because it can replicate within bladder cancer cells and then trigger an anti-tumor response. This means it destroys cancer cells while sparing normal, healthy cells.</p> <p>“We are excited to participate in this nationwide clinical trial. The results will provide crucial data to determine if Cretostimogene can help reduce recurrence and improve survival rates for our patients with this type of bladder cancer,” said <a href="https://physicians.ucdavis.edu/medicalcenter/details/43227/thenappan-thenu-chandrasekar-genitourinary_cancers-urologic_oncology-urologic_surgery-urology-sacramento">Thenappan Chandrasekar</a>, a urologist and associate professor with the <a href="https://health.ucdavis.edu/urology/">Department of Urologic Surgery</a>. Chandrasekar is leading the PIVOT-006 clinical trial at <a href="https://health.ucdavis.edu/welcome/">UC Davis Health</a>.</p> <blockquote class="pullquote with-img mt-n2 pb-5 mb-5"> <div class="img-wrapper mt-5 mt-sm-2 mt-xl-n3 mb-2 mb-sm-0 mx-auto mr-sm-4"><img class="img-fluid" loading="lazy" src="/media-resources/contenthub/health-news/2024/11/body/chandrasekar-thenappan-quote.jpg" alt="Man with white coat and glasses smiling into camera" width="281" height="281"></div><span class="text">This could represent a major step forward in addressing the unmet medical needs of these patients. We are hopeful that this will allow us to do much more than monitor for recurrence, but actually give us a fighting chance to stop the cancer in its tracks.”<span class="caption mt-4"><span class="dash mr-2">—</span><span class="content">Thenappan Chandrasekar, associate professor, Department of Urologic Surgery</span></span></span></blockquote><h2>Clinical trial may make big strides in creating treatment alternative</h2> <p>In the past, a drug therapy called <a href="https://bcan.org/bcg-treatment-for-bladder-cancer/">Bacille Calmette-Guerin</a> that comes from a form of the tuberculosis vaccine has been used in IR-NMIBC patients to try to activate the immune system to attack the cancer. However, the live vaccine has been in short supply for many years due to stringent manufacturing requirements. This means that only a small percentage of IR-NMIBC patients can access the drug.</p> <p>The Phase 3 PIVOT-006 study is a randomized trial designed to assess whether adding Cretostimogene therapy after surgery improves patient outcomes compared to surgery alone. If successful, this therapy could offer a new, more effective treatment option for patients struggling with this challenging cancer.</p> <p>“This could represent a major step forward in addressing the unmet medical needs of these patients,” Chandrasekar said. “We are hopeful that this will allow us to do much more than monitor for recurrence, but actually give us a fighting chance to stop the cancer in its tracks.”</p></div> <div class="bg-gold-10 boilerplate basic-content p-4"> <p><p><strong>UC Davis Comprehensive Cancer Center</strong></p> <p>UC Davis Comprehensive Cancer Center is the only National Cancer Institute-designated center serving the Central Valley and inland Northern California, a region of more than 6 million people. Its specialists provide compassionate, comprehensive care for more than 100,000 adults and children every year and access to more than 200 active clinical trials at any given time. Its innovative research program engages more than 240 scientists at UC Davis who work collaboratively to advance discovery of new tools to diagnose and treat cancer. Patients have access to leading-edge care, including immunotherapy and other targeted treatments. Its Office of Community Outreach and Engagement addresses disparities in cancer outcomes across diverse populations, and the cancer center provides comprehensive education and workforce development programs for the next generation of clinicians and scientists. For more information, visit <a href="https://cancer.ucdavis.edu/">cancer.ucdavis.edu</a>.</p></p> </div> <div xmlns:xs="http://www.w3.org/2001/XMLSchema" class="article-footer sizer col-lg-10 mt-sm-5"> <div class="row mx-0 info-block"> <div class="category-block article-body mb-3 mb-sm-5"> <h2 class="category-header">Explore related topics</h2> <div class="categories col-12 px-0"><a class="btn btn-secondary py-2 px-3 mb-3 mr-2" href="/news/topic/urology">Urology</a><a class="btn btn-secondary py-2 px-3 mb-3 mr-2" href="/news/topic/general-health-news">General Health News</a><a class="btn btn-secondary py-2 px-3 mb-3 mr-2" href="/news/topic/research">Research</a><a class="btn btn-secondary py-2 px-3 mb-3 mr-2" href="/news/topic/cancer">Cancer Care</a></div> </div> <div class="col-12 contact-box mb-3 px-0"><strong class="news-contact-title">Media Contact</strong><div class="news-contacts mt-2 pt-2"><a href="/newsroom/contactus/index.html" class="btn btn-link btn-sm chevron-right w-100 mb-5" title="News Contacts">See our media contacts page</a><br></div> </div> </div> </div> </div> </div> </div> </article> </div> </div> <div class="iw_component" id="iw_comp1639757361071"> <style>#iw_comp1639757361071{}</style><div class="card-trio dark mb-7"> <div class="wrapper d-flex justify-content-center pt-7 pb-5 pb-sm-0"> <div class="sizer col-lg-10 px-sm-3"> <div class="section-header mb-5"><span class="section-title underlined mb-2 pb-3">Related Articles</span></div> <div class="card-container row row-cols-1 row-cols-sm-3 d-flex justify-content-center px-6 px-sm-4 px-lg-3"> <div class="card col mb-3 mb-sm-0 mx-0 pl-0 pr-3 pr-lg-5"> <div class="card-img"><a title="go to article" href="/news/headlines/cancer-center-to-host-first-ever-global-oncology-symposium-dec-12/2024/11"> <div class="img-wrapper d-flex justify-content-center align-items-center"><img class="card-img-top" loading="lazy" width="450" height="308" 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UC Davis Health is first in the region to launch unique bladder cancer clinical trial