Companion Diagnostics (CDx) Development

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <noscript><style>form.antibot * :not(.antibot-message) { display: none !important; }</style> </noscript><meta name="applicable-device" content="pc,mobile" /> <meta name="description" content="Bio-Techne is a trusted partner in development of companion diagnostics. 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Proteomics enhances personalized medicine by providing crucial insights into individual patient biology, disease mechanisms, and treatment responses, ultimately leading to more precise and effective healthcare. Biomarker Discovery: Identifies protein markers for early disease detection and prognosis. Pharmacoproteomics: Studies protein-drug interactions, aiding in treatment selection and monitoring. Integrated multiomics: Combines with genomics and transcriptomics for comprehensive disease understanding. Therapeutic Monitoring: Tracks treatment efficacy through protein expression changes. Precision Diagnostics: Enables more accurate disease classification and patient stratification." } },{ "@type": "Question", "name": "What is the validation process for protein biomarkers used in clinical testing?", "acceptedAnswer": { "@type": "Answer", "text": "The validation of protein biomarkers for clinical testing is a multi-step process that involves both analytical and clinical validation to ensure their reliability and utility in a clinical setting. This process is essential for translating biomarker discoveries into practical tools that can improve patient care. Steps in the Validation Process Defining Biomarkers and Purpose: Initial identification and proof-of-concept studies to define the biomarker and its intended use. Assay Development and Optimization: Designing and optimizing the assay, including selecting appropriate reagents and probes, and minimizing cross-reactivity. Analytical Validation: Conducting rigorous testing to establish the assay's performance characteristics. Clinical Validation: Conducting studies to demonstrate the biomarker's clinical relevance and utility. Documentation and Continuous Improvement: Documenting all validation steps and continuously improving the assay based on new data and technological advancements. Regulatory Considerations Submission to Regulatory Agencies: Providing comprehensive data on both analytical and clinical validation to regulatory bodies such as the US FDA. Compliance with Standards: Ensuring that the biomarker assay is performed in a CLIA-certified laboratory and consistently meets all regulatory standards for clinical diagnostics" } },{ "@type": "Question", "name": "How can Bio-Techne’s CDx services accelerate my drug development journey?", "acceptedAnswer": { "@type": "Answer", "text": "Partnering with Bio-Techne can accelerate assay development, ensure compliance, enhance your market strategy, and ultimately improves patient care in precision medicine. Benefits of Bio-Techne Partnerships for CDx: Specialized Expertise: Access to diagnostic development and validation know-how Regulatory Experience: Streamlined navigation of complex approval processes with successful IVD registrations across the globe, including Australia, Canada, Europe, Korea, the United Kingdom, and the United States Cost-Effectiveness: Avoid building expensive in-house capabilities Technological Access: Leverage our innovative proteomic, multiomic, and exosome isolation and analyte enrichment technologies, our established immunoassay platforms, and best in class antibody and protein reagents Market Penetration: Utilize our established global channels and commercialization networks Improved Outcomes: Better patient selection for targeted therapies Broad Portfolio: Our broad portfolio provides access to proprietary chemistries including liquid biopsy, which offer a unique avenue for protein biomarker discovery" } }] }</script> <meta http-equiv="content-language" content="en" /> <link rel="alternate" hreflang="en" href="https://www.bio-techne.com/diagnostics/companion-diagnostics" /> <link rel="alternate" hreflang="zh-hans" href="https://www.bio-techne.com/cn/diagnostics/companion-diagnostics" /> <link rel="icon" href="/themes/custom/bio_techne_global/favicon.ico" type="image/vnd.microsoft.icon" /> <link rel="preconnect" href="https://resources.bio-techne.com" /> <link rel="preconnect" href="https://resources.tocris.com" /> <link rel="preconnect" href="https://i.icomoon.io" /> <link rel="preconnect" href="https://cdn.icomoon.io" /> <link rel="dns-prefetch" href="https://connect.facebook.net" /> <link rel="dns-prefetch" href="https://resources.bio-techne.com" /> <link rel="dns-prefetch" href="https://snap.licdn.com" /> <link rel="dns-prefetch" href="https://www.google-analytics.com" /> <link rel="dns-prefetch" href="https://munchkin.marketo.net" /> <link rel="dns-prefetch" href="https://resources.tocris.com" /> <link rel="dns-prefetch" href="https://i.icomoon.io" /> <link rel="dns-prefetch" href="https://cdn.icomoon.io" /> <title>Companion Diagnostics (CDx) Development | Bio-Techne</title> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_ZxgPvtjfU58dVOS4x7hBdmXFv-da3Cr5fEZJ4OaYVB4.css?delta=0&language=en&theme=bio_techne_global&include=eJxNzmFuwyAMBeALQTiSZcBNvDiYGuiUnX5J06399aTP0vMzalVL4wdBxygEN5ZOFuzf_dNd21unLURs5CIrdEpLIZhFI0q4wre-C5fZfd0H2Q6DoVUu5eh7pUuqKxMU7XzjhJ21hMv8p_komlZX0XA2rEsL2UZFmd4yjVJHFG4LZSe46-gQB0s-vvVvTSrQKJ1lLgr-7EEU8zmumuaR-nFFS0u4AiKe47aNLBHcB6dV7az6M_-26TnuF94DfJ4" /> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_d9gn2GRzRb_AMxXfgjVqY5zLMXvuwkXc1qKvoeAAIxE.css?delta=1&language=en&theme=bio_techne_global&include=eJxNzmFuwyAMBeALQTiSZcBNvDiYGuiUnX5J06399aTP0vMzalVL4wdBxygEN5ZOFuzf_dNd21unLURs5CIrdEpLIZhFI0q4wre-C5fZfd0H2Q6DoVUu5eh7pUuqKxMU7XzjhJ21hMv8p_komlZX0XA2rEsL2UZFmd4yjVJHFG4LZSe46-gQB0s-vvVvTSrQKJ1lLgr-7EEU8zmumuaR-nFFS0u4AiKe47aNLBHcB6dV7az6M_-26TnuF94DfJ4" /> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/5631","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"gtm":{"tagId":null,"settings":{"data_layer":"dataLayer","include_environment":false},"tagIds":["GTM-N2MWQDR"]},"gtag":{"tagId":"","consentMode":false,"otherIds":[],"events":[],"additionalConfigInfo":[]},"ajaxPageState":{"libraries":"eJxtk22W2yAMRTcEYUkcgRVbDUZUyMl4Vl_5I8m0zR-QLg_zEHIijop5qhjHwglKSMzaVaDFPFSX_ls_Jt91LVTHDwLKPDN_2lrge_WFYfiwNuNA4L3gzIr-TgPypjpFhe4YYcSq4QX9Bv0OLUwCsrq0HRH28Yxzgd4LdT3z4_g9bFzWK5XyTIVn6nhmAtczemBqFjLPgpCn2OgLSxhAocCK4tvSJxSXNGKdoGYcIloJZpSMIal_Uv-ivpPiw67o8W7uu3vJX4qjKq-F-HuhfGMZUN6aN7uYvXwzNd8IY2WlK2VQ4hoO5n8yf6hfNwgJJ7gTS3do1VLKsYFOcekoEXLmxTyGM7AX0kWqb1Z4K3u9uZF5LBgVxjDa8G9-gV_w9TecHVVFqbsbKPT9tGrfl9V3LJj1cOlbgYwTF7ulM7e8aEwLbWnQB2cusZvYtrsGAqP17dTDIEuDcnmTy1LbkqwNJhycPfSwZLWNIHkKxxQTiBPsjWvfmk0hmV9rDzMa3tzv3PW1K84hgfXLXiaqV5b5uMcG_A_w_Ff-ACiBVz0","theme":"bio_techne_global","theme_token":null},"ajaxTrustedUrl":[],"dataLayer":{"defaultLang":"en","languages":{"en":{"id":"en","name":"English","direction":"ltr","weight":0},"zh-hans":{"id":"zh-hans","name":"Chinese, Simplified","direction":"ltr","weight":1},"ja":{"id":"ja","name":"Japanese","direction":"ltr","weight":2}}},"internationalization":{"origin":{"id":"ie","label":"IE","country_name":"Ireland","alternate_spellings":"IE","country_enabled":true,"country_encased":false,"commerce_enabled":true,"credit_cards_enabled":false,"region":"EMEA","currency":"EUR","localities":"[{\u0022text\u0022:\u0022Co. 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Our readiness for clinical trial sample testing in on-site CLIA labs, combined with diagnostic kit manufacturing and international regulatory expertise, enables us to provide customizable solutions. </p> <p>Our expertise in CDx Development allows our pharma partners to enhance the likelihood of their drug's success and expedite the delivery of novel treatments to the patients who stand to benefit the most.</p></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_call_to_action_global"> <a href="#contact" class="btn btn-primary" type="link"> Partner to Accelerate your CDx Development </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <article> <div class="youtube-video-place"> <lite-youtube videoid="fO03eriB6p8" params="rel=0" style="background-image: url('https://img.youtube.com/vi/fO03eriB6p8/maxresdefault.jpg');"> <a href="https://www.youtube.com/embed/fO03eriB6p8?autoplay=1" class="lty-playbtn" title="Bio-Techne - Together Transforming Companion Diagnostics"> <span class="lyt-visually-hidden">Bio-Techne - Together Transforming Companion Diagnostics</span> </a> </lite-youtube> </div> </article> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2>Multiomic Analysis Platform</h2> <p>Bio-Techne’s multiomics platform provides a comprehensive view of disease by combining genomic data with data from other modalities, including transcriptomics, epigenomics, and proteomics. This approach enables a multifaceted understanding of the molecular changes contributing to disease, allowing researchers to connect genotypes to phenotypes and discover novel drug targets and biomarkers.</p> <p><strong><a href="https://www.bio-techne.com/diagnostics/companion-diagnostics/multiomics" target="_blank">Learn More About Our Multiomics Platform</a></strong></p></div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p> </p> <p> </p></div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default"> <div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_header_2_global"> <div><h2>Your Partner from Biomarker Discovery to Commercialization</h2></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><h3>We offer a wide range of precision medicine services from discovery to validation and beyond.</h3> <p>Bio-Techne has an experienced regulatory team with a track record of FDA and international engagement to support a broad range of submissions, including 510(k), De Novo Requests, and PMA.</p> <ul> <li> <p><strong>Multiple CAP-accredited CLIA-certified labs: </strong>Supporting clinical testing needs</p> </li> <li> <p><strong>Kitting & Manufacturing:</strong> We offer kit development as well as cGMP manufacturing in our FDA-registered ISO 13485 facility.</p> </li> <li> <p><strong>Global Presence:</strong> Commercial reach in over 50 countries, over 200 labs are active users.</p> </li> </ul></div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/icons/biomarker-discovery-commercialization-flow.png" alt="Biomarker discovery to commercialization process" loading="lazy" > </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p> </p> <p> </p></div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2>Dynamic Expertise in Companion Diagnostics</h2></div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <div class="row card_row"> <div class="col-md-6"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/diagnostics/companion-diagnostics/protein-biomarker-discovery" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/dna-rna-protein-iconv2.png" alt="DNA + RNA + Protein CDx Icon" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/diagnostics/companion-diagnostics/protein-biomarker-discovery" > <h3 class="card_title_htag"> <div><h3>Expertise Spanning Platforms, Sample Types, Analytes, and Diseases</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Harness our technologies that unlock challenging regions of <a href="/diagnostics/amplidex-genetic-testing-kits">DNA</a> and <a href="/diagnostics/quantidex-oncology-testing-kits">RNA</a> with streamlined, multiplex workflows.</p> <ul> <li> <p>Complex single nucleotide variants</p> </li> <li> <p>Pseudogene discrimination</p> </li> <li> <p>Gene conversions</p> </li> <li> <p>Methylation</p> </li> </ul> <p>Tap into our extensive portfolio of industry leading proteins, antibodies, and immunoassays with fit-for-purpose development and validation to eliminate commercial barriers and ensures long-term supply continuity. </p> <ul> <li> <p>Automated <a href="/instruments/simple-western">Simple Western</a> and <a href="/instruments/simple-plex">Simple Plex ELISAs</a> </p> </li> <li> <p>Olink® Target 96 Gold-certified service provider </p> </li> <li> <p><a href="/reagents/elisa-kits/quantikine">Quantikine ELISAs</a> and <a href="/reagents/luminex-assays">Luminex multiplex immunoassays</a></p> </li> </ul></div> </div> <div class="card-bottom-link"> <div> <a href="/diagnostics/companion-diagnostics/protein-biomarker-discovery" > Learn More About Our Protein Capabilities </a> </div> </div> </div> </div> </div> <div class="col-md-6"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/resources/literature/dynamic-neuronal-exosomal-biomarkers" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/exosome-CDx-iconv2.png" alt="Exosome CDx Icon" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/resources/literature/dynamic-neuronal-exosomal-biomarkers" > <h3 class="card_title_htag"> <div><h3>Exosome Isolation & Analysis</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Stratify response to therapies and potential for segmentation in patient populations or understand therapy resistance leveraging our <a href="/diagnostics/exosome">exosome-based platform</a>.  </p> <p>Exosomes are powerful diagnostic tools because they: </p> <ul> <li> <p>Are secreted by all living cells and number in the billions per milliliter. </p> </li> <li> <p>Contain content reflective of the cell of origin allowing for non-invasive collection rather than tissue-only biopsy. </p> </li> <li> <p>Are a stable sample amenable to frozen storage from CSF, plasma, or other biofluid. </p> </li> <li> <p>Enables multiomic analysis of gene expression biomarkers, DNA variants (e.g. splice variants, fusions), and proteins to increase assay sensitivity</p> </li> </ul></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/literature/dynamic-neuronal-exosomal-biomarkers" > Dynamic Neuronal Exosomal Biomarkers in Cell Culture Medium </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p> </p> <p> </p></div> </div> </div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/track-record-success-v2.png" alt="CDx Demonstrated Track Record of Success" loading="lazy" > </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p> </p> <p> </p></div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/reagents/Amplidex.Quantindex.Explution_Display1400x600.png" alt="ExoLution Plus Asuragen Packaging" loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div><h2>International Distribution of Kitted Products</h2></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>We have 11 kits on the market, including products with FDA clearance, CE-IVD, Australian and Korean labeling.</p> <ul> <li>Commercial reach in over 50 countries, over 200 labs are active users</li> <li>cGMP manufacturing in our FDA registered ISO 13485 facility</li> <li>Technical support and scientific affairs team</li> <li>International field application support</li> </ul></div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <h2>Additional Resources for Companion Diagnostics</h2> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/resources/literature/complex-molecular-genetic-testing-made-simple" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/dna-strand-350x350.png" alt="3d image of a dna strand" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/resources/literature/complex-molecular-genetic-testing-made-simple" > <h3 class="card_title_htag"> <div><h3>Complex Molecular Genetic Testing Made Simple</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Asuragen, a Bio-Techne brand's <a href="/diagnostics/amplidex-genetic-testing-kits" target="_self">AmplideX<sup>®</sup></a> testing technology accelerates the journey from Clinical Trial Assay (CTA) to Companion Diagnostics (CDx) by reliably amplifying GC-rich and other repetitive DNA sequences to develop treatments for specific gene types. This accomplishment is shown through partnerships such as:</p> <ul> <li><a href="/resources/literature/pcr-ce-selecting-huntingtons-disease-patients-for-allele-selective-treatments-poster" target="_self">Wave Life Sciences and Asuragen’s development of a CTA targeting the <em>HTT</em> gene</a> </li> <li>Zynerba and <a href="https://asuragen.com/" target="_blank">Asuragen’s</a> partnership in the RECONNECT Trial for <a href="https://asuragen.com/discoverfragilex/" target="_blank">Fragile X Syndrome</a></li> </ul></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/literature/complex-molecular-genetic-testing-made-simple" > Find Out More in the AmplideX White Paper </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/resources/literature/quantidex-cdx-accelerating-the-drug-development-journey" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/cdx-quantidex-cancer-cell-350x350.png" alt="general cancer cell b" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/resources/literature/quantidex-cdx-accelerating-the-drug-development-journey" > <h3 class="card_title_htag"> <div><h3>Accelerating the Drug Development Journey</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>The <a href="/diagnostics/quantidex-oncology-testing-kits" target="_self">QuantideX<sup>®</sup></a> technology can be adapted to monitor disease burden in diseases requiring highly sensitive detection and/or quantitation across multiple nucleic acid targets. It can also be utilized for designing high performing, efficient, and simplified kits for genetic targets with unmet biomarker development and CTA needs.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/literature/quantidex-cdx-accelerating-the-drug-development-journey" > Find Out More in the QuantideX White Paper </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/diagnostics/companion-diagnostics/power-of-exosomes" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/asu-diagnostics-exo-cell-hero-480x480.png" alt="exosome" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/diagnostics/companion-diagnostics/power-of-exosomes" > <h3 class="card_title_htag"> <div><h3>Exosome Isolation for Biomarker Discovery in Companion Diagnostics</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Exosomes can be integrated into your therapeutic development journey from translational biomarker discovery through downstream development of clinical trial assays and CDx products.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/diagnostics/companion-diagnostics/power-of-exosomes" > Learn How Exosomes Can Accelerate Your Journey </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <h2>Partner from Discovery to Commercialization</h2> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/resources/literature/next-generation-biomarker-discovery-and-diagnostics" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/bt-cdx-brain-nobckgrnd.png" alt="CDx Media to Text Brain" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/resources/literature/next-generation-biomarker-discovery-and-diagnostics" > <h3 class="card_title_htag"> <div><h3>Biomarker Discovery & Diagnostics for Neurological Diseases</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>As exosomes pass through the blood-brain barrier, <a href="/diagnostics/companion-diagnostics/power-of-exosomes">exosome-based diagnostics</a> are likely to have considerable impact in Alzheimer’s and Parkinson’s diseases and other neurological conditions with high unmet need.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/literature/next-generation-biomarker-discovery-and-diagnostics" > Read More about Bio-Techne's Neuroscience Applications </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/resources/literature/cfdna-harnessing-power-of-exosomes" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/graphs/exosome-cdx-1050x600.png" alt="CDx Exosome" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/resources/literature/cfdna-harnessing-power-of-exosomes" > <h3 class="card_title_htag"> <div><h3>Beyond cfDNA: Harnessing the Power of Exosomes for Improved Sensitivity</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Blood-based liquid biopsies are making inroads in cancer management and are increasingly used in conjunction with tissue biopsies. Plasma cfDNA, ctDNA and exoRNA can be used to molecularly profile cancer patients and guide downstream treatment decisions.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/literature/cfdna-harnessing-power-of-exosomes" > View Data from Four Peer-Reviewed Articles </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="d-flex flex-column h-100"> <a href="/resources/literature/pcr-ce-selecting-huntingtons-disease-patients-for-allele-selective-treatments-poster" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: #f5f5f5; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/bt-electrophysiology-hero-img.png" alt="Electrophysiology Neuron Hero Image" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/resources/literature/pcr-ce-selecting-huntingtons-disease-patients-for-allele-selective-treatments-poster" > <h3 class="card_title_htag"> <div><h3>Partnership with Wave Life Sciences</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p><a href="https://www.asuragen.com" target="_blank">Asuragen</a>, a Bio-Techne brand, entered a partnership with Wave Life Sciences for the development and commercialization of companion diagnostics for Wave’s investigational allele-selective therapeutic programs targeting Huntington’s disease (HD).</p></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/literature/pcr-ce-selecting-huntingtons-disease-patients-for-allele-selective-treatments-poster" > More Information About the Partnership Project </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p> </p> <p> </p></div> </div> </div> <div> <section class="paragraph paragraph--type--full-width-banner-with-image mb-4 paragraph--view-mode--default paragraph-background-color--light"> <div class="banner_background_image" data-bgimage="https://resources.bio-techne.com/bio-techne-assets/images/icons/gray-rectangle1110x260.png" style="background-repeat: no-repeat;"> <div> <div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/cdx-brochure-thumbnail-350x350-v5.png" alt="CDx Brochure Cover Thumbnail " loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><h2>Discover. 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