CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Lucio Cocco | AICCON - Associazione Italiana per la Promozione della Cultura della Cooperazione e del Non Profit - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="yQRbt61xqfAyBDwshHONTZIT2nbkA5fCQTKuEWNxXFX_TODNa3pK5nER0MoZjTFeEFtjqO4lbt0SeyI020Jf2g" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-3d36c19b4875b226bfed0fcba1dcea3f2fe61148383d97c0465c016b8c969290.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-79e78ce59bef0a338eb6540ec3d93b4a7952115b56c57f1760943128f4544d42.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-95367dc03b794f6737f30123738a886cf53b7a65cdef98a922a98591d60063e3.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-bfbac2a470372e2f3a6661a65fa7ff0a0fbf7aa32534d9a831d683d2a6f9e01b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-170d1319f0e354621e81ca17054bb147da2856ec0702fe440a99af314a6338c5.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-2b6f90dbd75f5941bc38f4ad716615f3ac449e7398313bb3bc225fba451cd9fa.css" /> <meta name="author" content="lucio cocco" /> <meta name="description" content="Education1976 M.D.- University of Chieti (summa cum laude)1978 Ph.D.- Sport Medicine, University of Chieti, School of MedicinePositions held: 1979-1983:…" /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = 'dc2ad41da5d7ea682babd20f90650302fb0a3a36'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":14016,"monthly_visitors":"97 million","monthly_visitor_count":97692212,"monthly_visitor_count_in_millions":97,"user_count":282975262,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1739789674000); window.Aedu.timeDifference = new Date().getTime() - 1739789674000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link rel="preload" href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" as="style" onload="this.rel='stylesheet'"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-40698df34f913bd208bb70f09d2feb7c6286046250be17a4db35bba2c08b0e2f.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-a22f75d8519394c21253dae46c8c5d60ad36ea68c7d494347ec64229d8c1cf85.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-5708a105dd66b4c7d0ef30b7c094b1048423f0042bd2a7b123f2d99ee3cf46d9.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://aiccon.academia.edu/LCocco" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-c0b60aedadfb9d46b698730fbbcb2e70645c886b405d825adeba3a031c02455d.js" defer="defer"></script><script>$viewedUser = Aedu.User.set_viewed( {"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco","photo":"https://0.academia-photos.com/32694906/45746426/35573298/s65_l..cocco.jpg","has_photo":true,"department":{"id":1104320,"name":"DIBINEM","url":"https://aiccon.academia.edu/Departments/DIBINEM/Documents","university":{"id":86765,"name":"AICCON - Associazione Italiana per la Promozione della Cultura della Cooperazione e del Non Profit","url":"https://aiccon.academia.edu/"}},"position":"Faculty Member","position_id":1,"is_analytics_public":false,"interests":[{"id":182022,"name":"Clinical Neurology","url":"https://www.academia.edu/Documents/in/Clinical_Neurology"},{"id":299651,"name":"Bulk Drugs and chemicals of pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Bulk_Drugs_and_chemicals_of_pharmaceutical_sciences"},{"id":36059,"name":"Environmentalism","url":"https://www.academia.edu/Documents/in/Environmentalism"},{"id":100966,"name":"Brain Plasticity","url":"https://www.academia.edu/Documents/in/Brain_Plasticity"},{"id":50396,"name":"Medecine","url":"https://www.academia.edu/Documents/in/Medecine"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://aiccon.academia.edu/LCocco","location":"/LCocco","scheme":"https","host":"aiccon.academia.edu","port":null,"pathname":"/LCocco","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-555bed2b-2e7a-49c1-9cab-ad50d9d86e68"></div> <div id="ProfileCheckPaperUpdate-react-component-555bed2b-2e7a-49c1-9cab-ad50d9d86e68"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="Lucio Cocco" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/32694906/45746426/35573298/s200_l..cocco.jpg" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Lucio Cocco</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://aiccon.academia.edu/">AICCON - Associazione Italiana per la Promozione della Cultura della Cooperazione e del Non Profit</a>, <a class="u-tcGrayDarker" href="https://aiccon.academia.edu/Departments/DIBINEM/Documents">DIBINEM</a>, <span class="u-tcGrayDarker">Faculty Member</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Lucio" data-follow-user-id="32694906" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="32694906"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">13</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">2</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">2</p></div></a><div class="js-mentions-count-container" style="display: none;"><a href="/LCocco/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data"></p></div></a></div><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;">Education1976  M.D.- University of Chieti (summa cum laude)1978  Ph.D.- Sport Medicine, University of Chieti, School of MedicinePositions held: 1979-1983: PostDoc., Beatson Inst. Cancer Res., Glasgow, Scotland, U.K.<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://ksu.academia.edu/DavidSeamon"><img class="profile-avatar u-positionAbsolute" alt="David Seamon" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/93547/25922/29662134/s200_david.seamon.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://ksu.academia.edu/DavidSeamon">David Seamon</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Kansas State University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://fu-berlin.academia.edu/JanSlaby"><img class="profile-avatar u-positionAbsolute" alt="Jan Slaby" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/328970/93577/11687357/s200_jan.slaby.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://fu-berlin.academia.edu/JanSlaby">Jan Slaby</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Freie Universität Berlin</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://wmich.academia.edu/MercedesTubino"><img class="profile-avatar u-positionAbsolute" alt="Mercedes Tubino-Blanco" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/1345425/853278/1169479/s200_mercedes.tubino.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://wmich.academia.edu/MercedesTubino">Mercedes Tubino-Blanco</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Western Michigan University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://jjay-cuny.academia.edu/MarciaEsparza"><img class="profile-avatar u-positionAbsolute" alt="Marcia Esparza" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/3734045/1340162/34161926/s200_marcia.esparza.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://jjay-cuny.academia.edu/MarciaEsparza">Marcia Esparza</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">John Jay College of Criminal Justice</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://haramaya.academia.edu/TadesseBekele"><img class="profile-avatar u-positionAbsolute" alt="Tadesse B Tafesse" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/6743434/2790658/3253573/s200_tadesse.bekele.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://haramaya.academia.edu/TadesseBekele">Tadesse B Tafesse</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Haramaya university</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://internationalafricau.academia.edu/IdrissaChirombo"><img class="profile-avatar u-positionAbsolute" alt="Idrissa Chilombo" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/11910995/3708206/134610849/s200_idrissa.chilombo.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://internationalafricau.academia.edu/IdrissaChirombo">Idrissa Chilombo</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">International University of Africa (IUA)</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/ijprs"><img class="profile-avatar u-positionAbsolute" alt="International Journal for Pharmaceutical Research Scholars (IJPRS)" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/18872828/5246417/9704006/s200_international_journal_for_pharmaceutical_research_scholars._ijprs_.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/ijprs">International Journal for Pharmaceutical Research Scholars (IJPRS)</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://ui-edu-ng.academia.edu/OladosuOjengbede"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://ui-edu-ng.academia.edu/OladosuOjengbede">Oladosu A Ojengbede</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Ibadan Nigeria</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://hcuge.academia.edu/MarieChieze"><img class="profile-avatar u-positionAbsolute" alt="Marie Chieze" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/32418847/9893035/40160695/s200_marie.chieze.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://hcuge.academia.edu/MarieChieze">Marie Chieze</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Hopitaux Universitaires de Genève</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://unicatt.academia.edu/MariannaMazza"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://unicatt.academia.edu/MariannaMazza">Marianna Mazza</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Università Cattolica del Sacro Cuore (Catholic University of the Sacred Heart)</p></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32694906" href="https://www.academia.edu/Documents/in/Clinical_Neurology"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://aiccon.academia.edu/LCocco","location":"/LCocco","scheme":"https","host":"aiccon.academia.edu","port":null,"pathname":"/LCocco","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Clinical Neurology"]}" data-trace="false" data-dom-id="Pill-react-component-27d6cede-5462-41cb-8ce1-03e2959713de"></div> <div id="Pill-react-component-27d6cede-5462-41cb-8ce1-03e2959713de"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32694906" href="https://www.academia.edu/Documents/in/Bulk_Drugs_and_chemicals_of_pharmaceutical_sciences"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Bulk Drugs and chemicals of pharmaceutical sciences"]}" data-trace="false" data-dom-id="Pill-react-component-140bb8aa-59dd-4804-b740-023bd1a1988e"></div> <div id="Pill-react-component-140bb8aa-59dd-4804-b740-023bd1a1988e"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32694906" href="https://www.academia.edu/Documents/in/Environmentalism"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Environmentalism"]}" data-trace="false" data-dom-id="Pill-react-component-be4aa9c0-ccaf-40a8-8cd4-34497e6294c1"></div> <div id="Pill-react-component-be4aa9c0-ccaf-40a8-8cd4-34497e6294c1"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32694906" href="https://www.academia.edu/Documents/in/Brain_Plasticity"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Brain Plasticity"]}" data-trace="false" data-dom-id="Pill-react-component-39878a85-0876-42d8-a78b-b197a4ff61ca"></div> <div id="Pill-react-component-39878a85-0876-42d8-a78b-b197a4ff61ca"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="32694906" href="https://www.academia.edu/Documents/in/Medecine"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Medecine"]}" data-trace="false" data-dom-id="Pill-react-component-6107d765-b6ca-4e77-8a54-a8b593263b8c"></div> <div id="Pill-react-component-6107d765-b6ca-4e77-8a54-a8b593263b8c"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Lucio Cocco</h3></div><div class="js-work-strip profile--work_container" data-work-id="122413165"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413165/Proapoptotic_Activity_and_Chemosensitizing_Effect_of_the_Novel_Akt_Inhibitor_2_i_S_i_1_1_i_H_i_Indol_3_yl_3_5_3_methyl_2_i_H_i_indazol_5_yl_pyridin_3_yl_oxypropan2_amine_A443654_in_T_Cell_Acute_Lymphoblastic_Leukemia"><img alt="Research paper thumbnail of Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2<i>S</i>)-1-(1<i>H</i>-Indol-3-yl)-3-[5-(3-methyl-2<i>H</i>-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia" class="work-thumbnail" src="https://attachments.academia-assets.com/117080865/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413165/Proapoptotic_Activity_and_Chemosensitizing_Effect_of_the_Novel_Akt_Inhibitor_2_i_S_i_1_1_i_H_i_Indol_3_yl_3_5_3_methyl_2_i_H_i_indazol_5_yl_pyridin_3_yl_oxypropan2_amine_A443654_in_T_Cell_Acute_Lymphoblastic_Leukemia">Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2<i>S</i>)-1-(1<i>H</i>-Indol-3-yl)-3-[5-(3-methyl-2<i>H</i>-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia</a></div><div class="wp-workCard_item"><span>Molecular Pharmacology</span><span>, Jun 24, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Constitutively activated AKT kinase is a common feature of T-cell acute lymphoblastic leukemia (T...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Constitutively activated AKT kinase is a common feature of T-cell acute lymphoblastic leukemia (T-ALL). Here, we report that the novel AKT inhibitor (2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2Hindazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) leads to rapid cell death of TALL lines and patient samples. Treatment of CEM, Jurkat, and MOLT-4 cells with nanomolar doses of the inhibitor led to AKT phosphorylation accompanied by dephosphorylation and activation of the downstream target, glycogen synthase kinase-3β. Effects were time-and dose-dependent, resulting in apoptotic cell death. Treatment of Jurkat cells with A443654 resulted in activation of caspase-2,-3,-6,-8, and-9. Apoptotic cell death was mostly dependent on caspase-2 activation, as demonstrated by preincubation with a selective pharmacological inhibitor. It is remarkable that A443654 was highly effective against the drug-resistant cell line CEMVBL100, which expresses 170-kDa P-glycoprotein. Moreover, A443654 synergized with the DNA-damaging agent etoposide in both drug-sensitive and drug-resistant cell lines when coadministered [combination index (CI) = 0.39] or when pretreated with etoposide followed by A443654 (CI = 0.689). The efficacy of A443654 was confirmed using blasts from six patients with TALL , all of whom displayed low levels of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and constitutive phosphorylation of Akt on Ser473. At 1 μM, the inhibitor was able to induce apoptotic cell death of TALL blast cells, as indicated by flow cytometric analysis of samples immunostained for active (cleaved) caspase-3. Because activated AKT is seen in a large percentage of patients with TALL , A443654, either alone or in combination with existing drugs, may be a useful therapy for primary and drug-resistant TALL .</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1b5cee3609ac4ec78adf8a3884f5183e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080865,"asset_id":122413165,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080865/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413165"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413165"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413165; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413165]").text(description); $(".js-view-count[data-work-id=122413165]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413165; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413165']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1b5cee3609ac4ec78adf8a3884f5183e" } } $('.js-work-strip[data-work-id=122413165]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413165,"title":"Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2\u003ci\u003eS\u003c/i\u003e)-1-(1\u003ci\u003eH\u003c/i\u003e-Indol-3-yl)-3-[5-(3-methyl-2\u003ci\u003eH\u003c/i\u003e-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia","internal_url":"https://www.academia.edu/122413165/Proapoptotic_Activity_and_Chemosensitizing_Effect_of_the_Novel_Akt_Inhibitor_2_i_S_i_1_1_i_H_i_Indol_3_yl_3_5_3_methyl_2_i_H_i_indazol_5_yl_pyridin_3_yl_oxypropan2_amine_A443654_in_T_Cell_Acute_Lymphoblastic_Leukemia","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080865,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080865/thumbnails/1.jpg","file_name":"pmc2659779.pdf","download_url":"https://www.academia.edu/attachments/117080865/download_file","bulk_download_file_name":"Proapoptotic_Activity_and_Chemosensitizi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080865/pmc2659779-libre.pdf?1722186016=\u0026response-content-disposition=attachment%3B+filename%3DProapoptotic_Activity_and_Chemosensitizi.pdf\u0026Expires=1739787211\u0026Signature=fZveLgxnWrWuyAZyRen3SoqUleTSa-~qucbfUHqpPhUqRYKGLVuZyvx02OkEaMG8lx4xDQmAZmCdbuEcjzVrZgQ1fjrDSZRB-rfCUCf98x4gTUif6hu6UT8m4JPJUy5Z4fi-4mmKWZxOgzqPmDch6m9jdMKkALVluNmLUL07AyAKPQENb3T0xv9ZwaT4v34fYk3en0TkHfoE2zp1koVwHrEoqmjHzPhzyqb2A~Ti2O5exT27-MODvKJIp4QZi-y5UNN4uNt3ohB2t8Kc8rI~j0UZ-2U0OrXhJbRXOQrwgJG8-u4X8qQDJ9I7mX7IOs3xjRs7RL1VUBtUdroBHHI34Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":117080864,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080864/thumbnails/1.jpg","file_name":"pmc2659779.pdf","download_url":"https://www.academia.edu/attachments/117080864/download_file","bulk_download_file_name":"Proapoptotic_Activity_and_Chemosensitizi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080864/pmc2659779-libre.pdf?1722186015=\u0026response-content-disposition=attachment%3B+filename%3DProapoptotic_Activity_and_Chemosensitizi.pdf\u0026Expires=1739787211\u0026Signature=aFEFLxufzBzxkuiyXXveN8Pi0ha-xHS6V72dceaf8GkY7sANtGEgqq7IeZ9F9iLKrsnJQdbK9yi1FPRCkiPoINC3J99QjkmDZv-Uo7D6vYi6OkzEyL-wULPImBHvpLDjWGiVLlD16je0LLn2Br6QAzMA9rwZiGBNBieiJzS9VTyenvt4OZdgKFCn1Wu3~32ORdd3HqnXQPwvm6fDaqPngmWNrVhspFg9WO6FImen9nAEaR7vJqBEkBPkl2ZK6spAn93uw-DMhSrW-de31DTUxVPCXs-y1X45MPvI30xY3btLQArq1YipMlL1xy41mndrI8W6SoKKSFAK~buOH7vppw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413164"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413164/Supplementary_Figure_1_from_Synergistic_Proapoptotic_Activity_of_Recombinant_TRAIL_Plus_the_Akt_Inhibitor_Perifosine_in_Acute_Myelogenous_Leukemia_Cells"><img alt="Research paper thumbnail of Supplementary Figure 1 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/117080863/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413164/Supplementary_Figure_1_from_Synergistic_Proapoptotic_Activity_of_Recombinant_TRAIL_Plus_the_Akt_Inhibitor_Perifosine_in_Acute_Myelogenous_Leukemia_Cells">Supplementary Figure 1 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="61afcc18ee9528dd9d134a557b5cf249" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080863,"asset_id":122413164,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080863/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413164"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413164"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413164; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413164]").text(description); $(".js-view-count[data-work-id=122413164]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413164; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413164']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "61afcc18ee9528dd9d134a557b5cf249" } } $('.js-work-strip[data-work-id=122413164]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413164,"title":"Supplementary Figure 1 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells","internal_url":"https://www.academia.edu/122413164/Supplementary_Figure_1_from_Synergistic_Proapoptotic_Activity_of_Recombinant_TRAIL_Plus_the_Akt_Inhibitor_Perifosine_in_Acute_Myelogenous_Leukemia_Cells","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080863,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080863/thumbnails/1.jpg","file_name":"39820943.pdf","download_url":"https://www.academia.edu/attachments/117080863/download_file","bulk_download_file_name":"Supplementary_Figure_1_from_Synergistic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080863/39820943-libre.pdf?1722186011=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_1_from_Synergistic.pdf\u0026Expires=1739787211\u0026Signature=Wj5hPA9cYhaj8a9UEB4y0yKXb2FWRcCr4QW-1D2UN-a497cbpuUKVhlIwIuB6DHIadc7Mtwslxa58eS7meaSH6EAprxUOtsGbtKf0Kg7QLrKiQIdlWc3hA5u~WLD718-GH5yGeQTpajBG~ILveizRw7kR7xThwnT5KnrGPAJUt0ojMEO~24POVGqTqwB5Sz4nltkSJmokJla90xm7eb5wvEfa1qJ7DL~6S~acNuSOI74SV~I5qfr25ZgRCkcfUO98~VO2pIkAdTaJyWeuCirZQHTNmrFhqvDT4gX4WbXgvsX0iHgLS8jBetU-0lbiVoQn9w1s3SmzO1-JE6LOL4aJA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":117080862,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080862/thumbnails/1.jpg","file_name":"39820943.pdf","download_url":"https://www.academia.edu/attachments/117080862/download_file","bulk_download_file_name":"Supplementary_Figure_1_from_Synergistic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080862/39820943-libre.pdf?1722186012=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_1_from_Synergistic.pdf\u0026Expires=1739787211\u0026Signature=PbOSJ4j6QZ5uuROr6xZWbT-Kb~pxVhaBVZqf2EqDHaeYrPwJCa9TS2GC6rnrWGhzIU7ONvAhfCI~IZGk5OfgrTbuWU6SbmP8m4ZbRB9AsfCNVQLQyyeH9cZ0Hwbi1LnJBMRCQDk2ldrw4FKLUAOa21jCGg8WcPbbKkdRHclES2npB7zGQxWdhDb9B5A4cHCztRsEwR0c1PKTW1~xoeCk5~hklR1TU6M3GbRpT3hPmOlAWYeDm13sCPp5Xtbyc20v3lLJGEfDMfY~8-pV8Zr8sOOAzJzvgeTip-oKY-h56tbfe4g5AYuGhd1hE2ZowMt3976E3DwKBTMQ-h18RRPwHQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413163"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413163/Supplementary_Figure_2_from_Synergistic_Proapoptotic_Activity_of_Recombinant_TRAIL_Plus_the_Akt_Inhibitor_Perifosine_in_Acute_Myelogenous_Leukemia_Cells"><img alt="Research paper thumbnail of Supplementary Figure 2 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/117080909/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413163/Supplementary_Figure_2_from_Synergistic_Proapoptotic_Activity_of_Recombinant_TRAIL_Plus_the_Akt_Inhibitor_Perifosine_in_Acute_Myelogenous_Leukemia_Cells">Supplementary Figure 2 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dcc60a62efce522f3e41edc33a606b0d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080909,"asset_id":122413163,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080909/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413163"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413163"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413163; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413163]").text(description); $(".js-view-count[data-work-id=122413163]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413163; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413163']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dcc60a62efce522f3e41edc33a606b0d" } } $('.js-work-strip[data-work-id=122413163]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413163,"title":"Supplementary Figure 2 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells","internal_url":"https://www.academia.edu/122413163/Supplementary_Figure_2_from_Synergistic_Proapoptotic_Activity_of_Recombinant_TRAIL_Plus_the_Akt_Inhibitor_Perifosine_in_Acute_Myelogenous_Leukemia_Cells","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080909,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080909/thumbnails/1.jpg","file_name":"39820940.pdf","download_url":"https://www.academia.edu/attachments/117080909/download_file","bulk_download_file_name":"Supplementary_Figure_2_from_Synergistic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080909/39820940-libre.pdf?1722185998=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_2_from_Synergistic.pdf\u0026Expires=1739787211\u0026Signature=fVKPjpO6x2Md2GUs7ZPGqh5kmDpEDMNkOeabxLZgS1wCAjnVoPQKow0nGRWsJVELskUwIKQJuhMAuTXLDXsTxJHXJz~6iUNjSdZ7A9rHDIBGIYsWBij6XOqZ93oK~u5Ha0geimgcQ5vtPnFa0AHLri9CKf8mfifkaG5FlsZ4uU0znlUS-myeUrqxtwRx8LK7rge6jtvkndN7rQLGCjgiujRb8pQ~BxGP~hjCnJs9o5KaeNKK3KJ4zoXp6GuHRMyi6yVjS5bRJd~PGTCrfu0~5Pp~ziIa6kTi7lyxge7UhJyrvm~PrmJyq6BJMdffG6EiK9AYKZOaScFwRriLXtNk4A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413162"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413162/Supplementary_Figure_S2_from_Prospective_Phase_II_Study_on_5_Days_Azacitidine_for_Treatment_of_Symptomatic_and_or_Erythropoietin_Unresponsive_Patients_with_Low_INT_1_Risk_Myelodysplastic_Syndromes"><img alt="Research paper thumbnail of Supplementary Figure S2 from Prospective Phase II Study on 5-Days Azacitidine for Treatment of Symptomatic and/or Erythropoietin Unresponsive Patients with Low/INT-1–Risk Myelodysplastic Syndromes" class="work-thumbnail" src="https://attachments.academia-assets.com/117080905/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413162/Supplementary_Figure_S2_from_Prospective_Phase_II_Study_on_5_Days_Azacitidine_for_Treatment_of_Symptomatic_and_or_Erythropoietin_Unresponsive_Patients_with_Low_INT_1_Risk_Myelodysplastic_Syndromes">Supplementary Figure S2 from Prospective Phase II Study on 5-Days Azacitidine for Treatment of Symptomatic and/or Erythropoietin Unresponsive Patients with Low/INT-1–Risk Myelodysplastic Syndromes</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Supplementary Figure S2 - PDF file 145K, Representation from Chromosome Analysis Suite (Chas, Aff...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Supplementary Figure S2 - PDF file 145K, Representation from Chromosome Analysis Suite (Chas, Affymetrix) of LOH alterations in analyzed MDS patients.The figure represents the LOH of the 5 patients with this abnormality and shows its distribution and its size within the chromosomes</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="971b4f13e11bf84cff8ed51a7b09c1f9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080905,"asset_id":122413162,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080905/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413162"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413162"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413162; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413162]").text(description); $(".js-view-count[data-work-id=122413162]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413162; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413162']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "971b4f13e11bf84cff8ed51a7b09c1f9" } } $('.js-work-strip[data-work-id=122413162]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413162,"title":"Supplementary Figure S2 from Prospective Phase II Study on 5-Days Azacitidine for Treatment of Symptomatic and/or Erythropoietin Unresponsive Patients with Low/INT-1–Risk Myelodysplastic Syndromes","internal_url":"https://www.academia.edu/122413162/Supplementary_Figure_S2_from_Prospective_Phase_II_Study_on_5_Days_Azacitidine_for_Treatment_of_Symptomatic_and_or_Erythropoietin_Unresponsive_Patients_with_Low_INT_1_Risk_Myelodysplastic_Syndromes","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080905/thumbnails/1.jpg","file_name":"39898256.pdf","download_url":"https://www.academia.edu/attachments/117080905/download_file","bulk_download_file_name":"Supplementary_Figure_S2_from_Prospective.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080905/39898256-libre.pdf?1722185998=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_S2_from_Prospective.pdf\u0026Expires=1739787211\u0026Signature=UZrb11au1MUiXnMWDWkkw8rEA3ZMNWLqL8tiScXrglipGRpFdqcm3T1GctDQkMUciQG07ijaFSSrlxtiKuMJH7hVxF-wVdo1SaX-vlkg0TVj4AAzbYCZl1StN00-uVWRUH4hVoNqmkzDziL74QxrQqwGlkZP~a4TQ8P6NlQti-KixpZvm1FABwmsKrzn6HfW-uM4VfL4ssenRSlb9N5LJCeCwe5F-uWNo2Gy0~-2ze7z7~9PAdjWoebj4FLiFSiahvdvrv~dsCCac0ML2Iz1UzutV5mRghe9gryDvOU1bGhmwORpHJ6PGQ8CovBhiCwHsxxZK4MXAyzvJj2BZ8P-1A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413161"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413161/Supplementary_Table_S1_from_Prospective_Phase_II_Study_on_5_Days_Azacitidine_for_Treatment_of_Symptomatic_and_or_Erythropoietin_Unresponsive_Patients_with_Low_INT_1_Risk_Myelodysplastic_Syndromes"><img alt="Research paper thumbnail of Supplementary Table S1 from Prospective Phase II Study on 5-Days Azacitidine for Treatment of Symptomatic and/or Erythropoietin Unresponsive Patients with Low/INT-1–Risk Myelodysplastic Syndromes" class="work-thumbnail" src="https://attachments.academia-assets.com/117080906/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413161/Supplementary_Table_S1_from_Prospective_Phase_II_Study_on_5_Days_Azacitidine_for_Treatment_of_Symptomatic_and_or_Erythropoietin_Unresponsive_Patients_with_Low_INT_1_Risk_Myelodysplastic_Syndromes">Supplementary Table S1 from Prospective Phase II Study on 5-Days Azacitidine for Treatment of Symptomatic and/or Erythropoietin Unresponsive Patients with Low/INT-1–Risk Myelodysplastic Syndromes</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Supplementary Table S1 - PDF file 69K, Summary of macroscopic CNAs and LOH alterations identified...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Supplementary Table S1 - PDF file 69K, Summary of macroscopic CNAs and LOH alterations identified in MDS patients and response to fourth cycle of 5d-Aza. The table summarizes the results of SNP karyotyping, LOH and CNAs in the 26 MDS patients for whom the an</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="735856e346e56fccf8c43621d69eea29" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080906,"asset_id":122413161,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080906/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413161"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413161"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413161; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413161]").text(description); $(".js-view-count[data-work-id=122413161]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413161; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413161']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "735856e346e56fccf8c43621d69eea29" } } $('.js-work-strip[data-work-id=122413161]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413161,"title":"Supplementary Table S1 from Prospective Phase II Study on 5-Days Azacitidine for Treatment of Symptomatic and/or Erythropoietin Unresponsive Patients with Low/INT-1–Risk Myelodysplastic Syndromes","internal_url":"https://www.academia.edu/122413161/Supplementary_Table_S1_from_Prospective_Phase_II_Study_on_5_Days_Azacitidine_for_Treatment_of_Symptomatic_and_or_Erythropoietin_Unresponsive_Patients_with_Low_INT_1_Risk_Myelodysplastic_Syndromes","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080906,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080906/thumbnails/1.jpg","file_name":"39898253.pdf","download_url":"https://www.academia.edu/attachments/117080906/download_file","bulk_download_file_name":"Supplementary_Table_S1_from_Prospective.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080906/39898253-libre.pdf?1722185997=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Table_S1_from_Prospective.pdf\u0026Expires=1739787211\u0026Signature=Icqd8-lOYUY7cq7bFirFJ9~DL8hxcXdRiAEmnMgOK1XIme-oHJjG4E9Jx6kIBTJ-eDXS9U2JKWoCdWyfFJ5D6Vb4Cv~uzMgli4ML67GEgHQ9q9uVLDmguv0URsRad7BEB6GFjYFmWDXcddQhXxbgnHWR2s8jI2SMhzEiHaBfKxqXME6iJ4QbWmjJOMv1KuTSfE6ByJ5CVGNLRzgPGtMnQPtV6kHz1fZOx6FA2NElrFqesKQvlQPMn138BiTa-9RMibod-HPNj0K6Vfw5E9XaK8vCfsewbWMkaUzzb2s9vVIk4oLOqv31AXidCRHeRCw7rTnRPuclGn28azpnMV-3Aw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413160"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413160/BMP_2_induced_expression_of_PLC_beta1_that_is_a_positive_regulator_of_osteoblast_differentiation"><img alt="Research paper thumbnail of BMP-2 induced expression of PLC beta1 that is a positive regulator of osteoblast differentiation" class="work-thumbnail" src="https://attachments.academia-assets.com/117080907/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413160/BMP_2_induced_expression_of_PLC_beta1_that_is_a_positive_regulator_of_osteoblast_differentiation">BMP-2 induced expression of PLC beta1 that is a positive regulator of osteoblast differentiation</a></div><div class="wp-workCard_item"><span>Italian journal of anatomy and embryology</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">C2C12 is an immortalized mouse myoblast cell line. The cells readily proliferate in high-serum co...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">C2C12 is an immortalized mouse myoblast cell line. The cells readily proliferate in high-serum conditions, and differentiate and fuse in low-serum conditions. While this cell line is a very useful tool to study aspects of myogenesis, metabolism and muscle biology, however, treatment of C2C12 cells with bone morphogenic protein (BMPs) induces cells to differentiate into osteoblasts. Osteoblast differentiation is controlled by diversified signaling proteins and transcription factors, essentially BMP-2, Osterix (Osx/Sp7) and Runx2, finally associating with the expression of late osteoblast marker genes, like ALPL and Bglap. These peculiarities make C2C12 progenitor cells a skillful prototype to investigate the molecular mechanism that control cell destiny specification and terminal differentiation. In the current investigation, we took improvement of the differentiation peculiarities of the mouse C2C12 cell line to analyze whether changes in PLCbeta1 expression and its nuclear localiza...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="114c41b05da915c2f13c478c11379e29" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080907,"asset_id":122413160,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080907/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413160"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413160"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413160; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413160]").text(description); $(".js-view-count[data-work-id=122413160]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413160; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413160']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "114c41b05da915c2f13c478c11379e29" } } $('.js-work-strip[data-work-id=122413160]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413160,"title":"BMP-2 induced expression of PLC beta1 that is a positive regulator of osteoblast differentiation","internal_url":"https://www.academia.edu/122413160/BMP_2_induced_expression_of_PLC_beta1_that_is_a_positive_regulator_of_osteoblast_differentiation","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080907,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080907/thumbnails/1.jpg","file_name":"228555143.pdf","download_url":"https://www.academia.edu/attachments/117080907/download_file","bulk_download_file_name":"BMP_2_induced_expression_of_PLC_beta1_th.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080907/228555143-libre.pdf?1722185999=\u0026response-content-disposition=attachment%3B+filename%3DBMP_2_induced_expression_of_PLC_beta1_th.pdf\u0026Expires=1739787211\u0026Signature=NvR6gLnHxvfdvHX2o9Et0UlrhaOaYduENRsVCL7x8xyAvdJN6djKE62UDrjBD5RqmqL7Z92UNyn9fB~tSRpCsBxvwSoN04eMcV7sHK8qMxZrUtzlzU4bdNm6XchjUx0AE1lACMU2FJpNJC2oSth7tzgUIboEmWtupUB-k1rxcQLwGdvvFz8YiCEsHoRKH14GiGXr-GvCQbFBtaocBDq-5S13Wv8dOF0CIfX4ryJT9U2r9TfUH9NnKrV~BLnPNW8mfcLRMWrU77coDkH88NbH86gevW2Faj8psN4yWM8Qqw85HLgSHfQLiAuh81WQBTm~7zo~7latIzijtsQQwvO4lg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413159"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413159/Cancer_therapy_and_treatments_during_COVID_19_era"><img alt="Research paper thumbnail of Cancer therapy and treatments during COVID-19 era" class="work-thumbnail" src="https://attachments.academia-assets.com/117080912/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413159/Cancer_therapy_and_treatments_during_COVID_19_era">Cancer therapy and treatments during COVID-19 era</a></div><div class="wp-workCard_item"><span>Advances in Biological Regulation</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The COVID-19 pandemic has put a serious strain on health treatments as well at the economies of m...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The COVID-19 pandemic has put a serious strain on health treatments as well at the economies of many nations. Unfortunately, there is not currently available vaccine for SARS-Cov-2/COVID-19. Various types of patients have delayed treatment or even routine checkups and we are adapting to a virtual world. In many cases, surgeries are delayed unless they are essential. This is also true with regards to cancer treatments and screening. Interestingly, some existing drugs and nutraceuticals have been screened for their effects on COVID-19. Certain FDA approved drugs, vitamin, natural products and trace minerals may be repurposed to treat or improve the prevention of COVID-19 infections and disease progression. This review article will summarize how the treatments of various cancer patients has changed during the COVID-19 era as well as discuss the promise of some existing drugs and other agents to be repurposed to treat this disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b148fb9f15b39e4495c1044e6b40e3b1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080912,"asset_id":122413159,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080912/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413159"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413159"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413159; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413159]").text(description); $(".js-view-count[data-work-id=122413159]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413159; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413159']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b148fb9f15b39e4495c1044e6b40e3b1" } } $('.js-work-strip[data-work-id=122413159]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413159,"title":"Cancer therapy and treatments during COVID-19 era","internal_url":"https://www.academia.edu/122413159/Cancer_therapy_and_treatments_during_COVID_19_era","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080912,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080912/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/117080912/download_file","bulk_download_file_name":"Cancer_therapy_and_treatments_during_COV.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080912/ptpmcrender-libre.pdf?1722186026=\u0026response-content-disposition=attachment%3B+filename%3DCancer_therapy_and_treatments_during_COV.pdf\u0026Expires=1739787211\u0026Signature=KMkBN~1Drl1nX4pURIps97yYiOY1AnF5a47eCnkGERcFpuvJT-hRnSPX5O31diYr73Jsmyu59~uKgXkO4Djrbp5Zl9MJ3qPmNaRN3m0eXP06jXIzWUvqWfHcyHmvzfMpe5k~E~ooKbVOEpH-GgMXKw5a96ybVngQcaPETyKEawmA-Bv4rei7wY4fUuf1vAIZrPWq2s3VYP9LJKCnv8Yz8Td2rp7GaQTAzlf89bxfd0FZxsFm6HfmWXVgf~1RCbgMtXvQvAmjTg5L6-NqBP84E3Z9mLTOMOujIOT~G1JXp5i0tvHVXpQoO2B9~mtfhqpB7NzRc-8jfzubYpPY5ZNFCw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413158"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413158/The_function_of_PLC%CE%B31_in_developing_mouse_mDA_system"><img alt="Research paper thumbnail of The function of PLCγ1 in developing mouse mDA system" class="work-thumbnail" src="https://attachments.academia-assets.com/117080904/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413158/The_function_of_PLC%CE%B31_in_developing_mouse_mDA_system">The function of PLCγ1 in developing mouse mDA system</a></div><div class="wp-workCard_item"><span>Advances in Biological Regulation</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">During neural development, growing neuronal cells consistently sense and communicate with their s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">During neural development, growing neuronal cells consistently sense and communicate with their surroundings through the use of signaling molecules. In this process, spatiotemporally wellcoordinated intracellular signaling is a prerequisite for proper neuronal network formation. Thus, intense interest has focused on investigating the signaling mechanisms in neuronal structure formation that link the activation of receptors to the control of cell shape and motility. Recent studies suggest that Phospholipase C gamma1 (PLCγ1), a signal transducer, plays key roles in nervous system development by mediating specific ligand-receptor systems. In this overview of the most recent advances in the field, we discuss the mechanisms by which extracellular stimuli trigger PLCγ1 signaling and, the role PLCγ1 in nervous system development.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="740d288b4d698802a3e13d3d01c4da2d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080904,"asset_id":122413158,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080904/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413158"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413158"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413158; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413158]").text(description); $(".js-view-count[data-work-id=122413158]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413158; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413158']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "740d288b4d698802a3e13d3d01c4da2d" } } $('.js-work-strip[data-work-id=122413158]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413158,"title":"The function of PLCγ1 in developing mouse mDA system","internal_url":"https://www.academia.edu/122413158/The_function_of_PLC%CE%B31_in_developing_mouse_mDA_system","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080904,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080904/thumbnails/1.jpg","file_name":"j.jbior.2019.10065420240728-1-hq91pt.pdf","download_url":"https://www.academia.edu/attachments/117080904/download_file","bulk_download_file_name":"The_function_of_PLC1_in_developing_mous.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080904/j.jbior.2019.10065420240728-1-hq91pt-libre.pdf?1722186000=\u0026response-content-disposition=attachment%3B+filename%3DThe_function_of_PLC1_in_developing_mous.pdf\u0026Expires=1739787211\u0026Signature=PL3eVHqMYaPMd5FMMISb~C7IJBEpRhA48kIBlgfLA7YWB5bYegSzwNKLW2VC7GsnBVoCfuUQTKWJmI3DmurZZzpy2MksniGQ8U1DLbeNbC4oMTBU~VtFIYHXA4Qm1rgkq33XGy~vgjffP891ASV6bUvOazCNFbmzEKCCbh5rEjIwCPm0Kq-yiNqhuJxCz4I8S1U918qJSGoeoLla6qhBXasDShSi6BSH0eIt~DCEbkYO9aobNXvS659qIL2w5p3ub0Et84cN9YkJEWm8oOX30jGTfjVHMOLTkha3TKCorw9UnRogzWHNyNJNyXVaoh382kq7Xk~sKMdDkWNTUpHdxQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413157"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413157/Anatomical_variations_of_the_right_renal_and_spermatic_arteries_a_case_report"><img alt="Research paper thumbnail of Anatomical variations of the right renal and spermatic arteries: a case report" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413157/Anatomical_variations_of_the_right_renal_and_spermatic_arteries_a_case_report">Anatomical variations of the right renal and spermatic arteries: a case report</a></div><div class="wp-workCard_item"><span>Italian journal of anatomy and embryology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Knowledge of the anatomy of renal vessels and their anatomical variations (diverse branching from...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Knowledge of the anatomy of renal vessels and their anatomical variations (diverse branching from abdominal aorta) represents an indispensable moment for planning and performing surgical operations in this area. Renal arteries originate from abdominal aorta at L1-L2 level. Normally the right renal artery passes behind inferior vena cava and right renal vein, the left one is shorter and passes behind left renal vein. Each renal artery gives inferior adrenal gland arteries and divides in four or five branches close to the hilum. Usually, shortly below the right renal artery, right gonadic artery arises and runs in front of the inferior vena cava. In our Department, during a routine gross anatomy dissection of a 98-year-old Caucasian male cadaver for undergraduated, postgraduated students and residents, we observed that right renal artery exhibit an early bifurcation. The two arteries have a peculiar running, in spite of the more frequent behavior. They cross each other at the middle of the path between abdominal aorta and renal hilum forming a sort of knot. The lower branch goes up looking like a superior polar artery, from which stems a short retropielic artery. Right gonadic artery originates from right renal artery in spite of its more frequent origin from abdominal aorta at L3 level. These monolateral variations are of course unusual but not responsible for any hemodynamic impairment. Probably as concerning the right renal artery variation it looks like that it is due to a non complete fusion of the primitive segmental arteries at the first steps of formation of right dorsalis aorta. This impinges on the fact that also the right gonadic artery stays close to the upper part of dorsalis aorta and therefore originates eventually from the right renal artery.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413157"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413157"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413157; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413157]").text(description); $(".js-view-count[data-work-id=122413157]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413157; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413157']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413157]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413157,"title":"Anatomical variations of the right renal and spermatic arteries: a case report","internal_url":"https://www.academia.edu/122413157/Anatomical_variations_of_the_right_renal_and_spermatic_arteries_a_case_report","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413156"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413156/Modulation_of_nuclear_PI_PLCbeta1_during_cell_differentiation"><img alt="Research paper thumbnail of Modulation of nuclear PI-PLCbeta1 during cell differentiation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413156/Modulation_of_nuclear_PI_PLCbeta1_during_cell_differentiation">Modulation of nuclear PI-PLCbeta1 during cell differentiation</a></div><div class="wp-workCard_item"><span>Advances in biological regulation</span><span>, Jan 26, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">PI-PLCbeta1 plays an important role in cell differentiation, and particularly in myogenesis, oste...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">PI-PLCbeta1 plays an important role in cell differentiation, and particularly in myogenesis, osteogenesis and hematopoiesis. Indeed, the increase of PI-PLCbeta1, along with Cyclin D3, has been detected in C2C12 mouse myoblasts induced to differentiate, as well as in human cells obtained from myotonic dystrophy. Also in the case of osteogenic differentiation there is a specific induction of PI-PLCbeta1, but in this case the role of PI-PLCbeta1 seems to be independent from Cyclin D3, so that a different mechanism could be involved. As for the hematopoietic system, PI-PLCbeta1 has a peculiar behavior: it increases during myeloid differentiation and decreases during erythroid differentiation, thus confirming the role of PI-PLCbeta1 as a modulator of hematopoiesis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413156"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413156"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413156; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413156]").text(description); $(".js-view-count[data-work-id=122413156]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413156; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413156']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413156]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413156,"title":"Modulation of nuclear PI-PLCbeta1 during cell differentiation","internal_url":"https://www.academia.edu/122413156/Modulation_of_nuclear_PI_PLCbeta1_during_cell_differentiation","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413154"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413154/Roles_of_EGFR_and_KRAS_and_their_downstream_signaling_pathways_in_pancreatic_cancer_and_pancreatic_cancer_stem_cells"><img alt="Research paper thumbnail of Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413154/Roles_of_EGFR_and_KRAS_and_their_downstream_signaling_pathways_in_pancreatic_cancer_and_pancreatic_cancer_stem_cells">Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells</a></div><div class="wp-workCard_item"><span>Advances in Biological Regulation</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pancreatic cancer is currently the fourth most common cancer, is increasing in incidence and soon...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pancreatic cancer is currently the fourth most common cancer, is increasing in incidence and soon will be the second leading cause of cancer death in the USA. This is a deadly malignancy with an incidence that approximates the mortality with 44,000 new cases and 36,000 deaths each year. Surgery, although only modestly successful, is the only curative option. However, due the locally aggressive nature and early metastasis, surgery can be performed on less than 20% of patients. Cytotoxic chemotherapy is palliative, has significant toxicity and improves survival very little. Thus new treatment paradigms are needed desperately. Due to the extremely high frequency of KRAS gene mutations (&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;90%) detected in pancreatic cancer patients, the roles of the epidermal growth factor receptor (EGFR), Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTORC1/GSK-3 pathways have been investigated in pancreatic cancer for many years. Constitutively active Ras can activate both of these pathways and there is cross talk between Ras and EGFR which is believed to be important in driving metastasis. Mutant KRAS may also drive the expression of GSK-3 through Raf/MEK/ERK-mediated effects on GSK-3 transcription. GSK-3 can then regulate the expression of NF-kappaB which is important in modulating pancreatic cancer chemoresistance. While the receptors and many downstream signaling molecules have been identified and characterized, there is still much to learn about these pathways and how their deregulation can lead to cancer. Multiple inhibitors to EGFR, PI3K, mTOR, GSK-3, Raf, MEK and hedgehog (HH) have been developed and are being evaluated in various cancers. Current research often focuses on the role of these pathways in cancer stem cells (CSC), with the goal to identify sites where therapeutic resistance may develop. Relatively novel fields of investigation such as microRNAs and drugs used for other diseases e.g., diabetes, (metformin) and malaria (chloroquine) have provided new information about therapeutic resistance and CSCs. This review will focus on recent advances in the field and how they affect pancreatic cancer research and treatment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413154"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413154"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413154; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413154]").text(description); $(".js-view-count[data-work-id=122413154]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413154; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413154']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413154]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413154,"title":"Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells","internal_url":"https://www.academia.edu/122413154/Roles_of_EGFR_and_KRAS_and_their_downstream_signaling_pathways_in_pancreatic_cancer_and_pancreatic_cancer_stem_cells","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413153"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413153/Nuclear_lipids_in_friend_cells_Shifted_profile_of_diacylglycerol_during_erythroid_differentiation_induced_by_DMSO"><img alt="Research paper thumbnail of Nuclear lipids in friend cells. Shifted profile of diacylglycerol during erythroid differentiation induced by DMSO" class="work-thumbnail" src="https://attachments.academia-assets.com/117080902/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413153/Nuclear_lipids_in_friend_cells_Shifted_profile_of_diacylglycerol_during_erythroid_differentiation_induced_by_DMSO">Nuclear lipids in friend cells. Shifted profile of diacylglycerol during erythroid differentiation induced by DMSO</a></div><div class="wp-workCard_item"><span>Cell Biology International Reports</span><span>, 1990</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="18f265a06c036705d9f600c39dde3bff" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080902,"asset_id":122413153,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080902/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413153"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413153"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413153; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413153]").text(description); $(".js-view-count[data-work-id=122413153]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413153; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413153']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "18f265a06c036705d9f600c39dde3bff" } } $('.js-work-strip[data-work-id=122413153]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413153,"title":"Nuclear lipids in friend cells. Shifted profile of diacylglycerol during erythroid differentiation induced by DMSO","internal_url":"https://www.academia.edu/122413153/Nuclear_lipids_in_friend_cells_Shifted_profile_of_diacylglycerol_during_erythroid_differentiation_induced_by_DMSO","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080902,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080902/thumbnails/1.jpg","file_name":"0309-165128902991183-520240728-1-4myabx.pdf","download_url":"https://www.academia.edu/attachments/117080902/download_file","bulk_download_file_name":"Nuclear_lipids_in_friend_cells_Shifted_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080902/0309-165128902991183-520240728-1-4myabx-libre.pdf?1722186002=\u0026response-content-disposition=attachment%3B+filename%3DNuclear_lipids_in_friend_cells_Shifted_p.pdf\u0026Expires=1739787211\u0026Signature=AzkGoGrnlrrYIVC-Jr7VJXplwDNWsaMnGKfVDixE7CJ-LFO5cd~YSs0jgp9ONz6O7IA5hjPT26JuQeSTjciJ0bhs3n8wiR~2z65f5MSM3vWz1C6IGEa5nAwy3q2M~KmqRKPTiEnjW7L41TJyiKDyPI7IevnRSjSGw7DDdl9Zkm9Tlr3Td6S28B-CnKtSfE73KVFcv~xThb93msMdxFWTxBFcHzst-NPAK1CyrCiKPnI81WNlXw5qR2ByWmUTrSJVXJ-XmxCgf1EDhF-AwQoIoOseXfZXCuLA5fYSu6Q7xdQ-mUolsvbD8C6kO1VnERdoVvmVlEALSo1g1oAabsUprw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413152"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413152/Phospholipids_as_components_of_the_nuclear_matrix_their_possible_biological_significance"><img alt="Research paper thumbnail of Phospholipids as components of the nuclear matrix: their possible biological significance" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413152/Phospholipids_as_components_of_the_nuclear_matrix_their_possible_biological_significance">Phospholipids as components of the nuclear matrix: their possible biological significance</a></div><div class="wp-workCard_item"><span>Basic and applied histochemistry</span><span>, 1987</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The phospholipid involvement in the regulation of the functional and structural properties of the...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The phospholipid involvement in the regulation of the functional and structural properties of the nuclear matrix is discussed analysing the results obtained with the enzymic removal of these molecules. Namely phospholipids seem to mediate hydrophobic interactions between nucleic acids and matrix fibrils either directly or indirectly through an association with the non-histone proteins of the matrix.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413152"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413152"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413152; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413152]").text(description); $(".js-view-count[data-work-id=122413152]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413152; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413152']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413152]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413152,"title":"Phospholipids as components of the nuclear matrix: their possible biological significance","internal_url":"https://www.academia.edu/122413152/Phospholipids_as_components_of_the_nuclear_matrix_their_possible_biological_significance","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413151"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413151/Phospholipase_C_%CE%B21_is_predominantely_expressed_in_the_granular_layer_of_rat_cerebellar_cortex"><img alt="Research paper thumbnail of Phospholipase-C β1 is predominantely expressed in the granular layer of rat cerebellar cortex" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413151/Phospholipase_C_%CE%B21_is_predominantely_expressed_in_the_granular_layer_of_rat_cerebellar_cortex">Phospholipase-C β1 is predominantely expressed in the granular layer of rat cerebellar cortex</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Medicine</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413151"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413151"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413151; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413151]").text(description); $(".js-view-count[data-work-id=122413151]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413151; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413151']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413151]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413151,"title":"Phospholipase-C β1 is predominantely expressed in the granular layer of rat cerebellar cortex","internal_url":"https://www.academia.edu/122413151/Phospholipase_C_%CE%B21_is_predominantely_expressed_in_the_granular_layer_of_rat_cerebellar_cortex","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413150"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413150/PLC%CE%B21a_and_PLC%CE%B21b_Selective_Regulation_and_Cyclin_D3_Modulation_Reduced_by_Kinamycin_F_During_K562_Cell_Differentiation"><img alt="Research paper thumbnail of PLCβ1a and PLCβ1b Selective Regulation and Cyclin D3 Modulation Reduced by Kinamycin F During K562 Cell Differentiation" class="work-thumbnail" src="https://attachments.academia-assets.com/117080903/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413150/PLC%CE%B21a_and_PLC%CE%B21b_Selective_Regulation_and_Cyclin_D3_Modulation_Reduced_by_Kinamycin_F_During_K562_Cell_Differentiation">PLCβ1a and PLCβ1b Selective Regulation and Cyclin D3 Modulation Reduced by Kinamycin F During K562 Cell Differentiation</a></div><div class="wp-workCard_item"><span>Journal of Cellular Physiology</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Here we report that both PLCβ1a and PLCβ1b are relevant regulators of erythropoiesis in that kina...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Here we report that both PLCβ1a and PLCβ1b are relevant regulators of erythropoiesis in that kinamycin F, a potent inducer of γ‐globin production in K562 cells, caused a selectively reduction of both PLCβ1 isozymes even though the results point out that the effect of the drug is mainly directed toward the expression of the PLCβ1a isoform. We have identified a different role for the two isozymes as regulators of K562 differentiation process induced by kinamycin F. The overexpression of PLCβ1b induced an increase in γ‐globin expression even in the absence of kinamycin F. Moreover during K562 differentiation, cyclin D3 level is regulated by PLCβ1 signaling pathway. Namely the amplification of the expression of the PLCβ1a, but not of PLCβ1b, is able to maintain high levels of expression of cyclin D3 even after treatment with kinamycin F. This could be due to their different distribution in the cell compartments since the amount of PLCβ1b is mainly present in the nucleus in respect to PL...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fe84e3de631c3296bf3798bb534cec2a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080903,"asset_id":122413150,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080903/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413150"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413150"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413150; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413150]").text(description); $(".js-view-count[data-work-id=122413150]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413150; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413150']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fe84e3de631c3296bf3798bb534cec2a" } } $('.js-work-strip[data-work-id=122413150]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413150,"title":"PLCβ1a and PLCβ1b Selective Regulation and Cyclin D3 Modulation Reduced by Kinamycin F During K562 Cell Differentiation","internal_url":"https://www.academia.edu/122413150/PLC%CE%B21a_and_PLC%CE%B21b_Selective_Regulation_and_Cyclin_D3_Modulation_Reduced_by_Kinamycin_F_During_K562_Cell_Differentiation","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080903,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080903/thumbnails/1.jpg","file_name":"jcp.2477620240728-1-at0kws.pdf","download_url":"https://www.academia.edu/attachments/117080903/download_file","bulk_download_file_name":"PLC1a_and_PLC1b_Selective_Regulation_a.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080903/jcp.2477620240728-1-at0kws-libre.pdf?1722186004=\u0026response-content-disposition=attachment%3B+filename%3DPLC1a_and_PLC1b_Selective_Regulation_a.pdf\u0026Expires=1739787211\u0026Signature=NP1S7zRSeij2glkx15UEZufRn~IEXOa2yB5NwlDf-aZ7ozMW3o~u16xYYPapugSt2OB8bazVxFw3U4aWN4FWflT~kqUnW-n4afhm8DrJITmLT2tx3mkigXLDyZnSgvK0E9fu09v23KMiCsxxIeImKVIylfoySu00BN40eLer0iS2TkXCVgGYngVVnLwXp6KJwK35LQJ-fUp7pm1ffaBK9roXI3izJSR7NZys~eudZhgJ15AZMG-G67sIGdY3NC0hYBf3a9uHfMR57BqHZz-YzaJuke5kkMiI87Kqp9JoocH1qMjuax6fdD2M4bMKxtnifq2DjjVv3i2AvtvSRmfy5Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413149"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413149/P060_Effect_of_azacitidine_on_PI_PLC_beta1_expression_and_Akt_activation_in_a_patient_affected_by_high_risk_myelodysplastic_syndrome_MDS_"><img alt="Research paper thumbnail of P060 Effect of azacitidine on PI-PLC-beta1 expression and Akt activation in a patient affected by high-risk myelodysplastic syndrome (MDS)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413149/P060_Effect_of_azacitidine_on_PI_PLC_beta1_expression_and_Akt_activation_in_a_patient_affected_by_high_risk_myelodysplastic_syndrome_MDS_">P060 Effect of azacitidine on PI-PLC-beta1 expression and Akt activation in a patient affected by high-risk myelodysplastic syndrome (MDS)</a></div><div class="wp-workCard_item"><span>Leukemia Research</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413149"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413149"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413149; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413149]").text(description); $(".js-view-count[data-work-id=122413149]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413149; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413149']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413149]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413149,"title":"P060 Effect of azacitidine on PI-PLC-beta1 expression and Akt activation in a patient affected by high-risk myelodysplastic syndrome (MDS)","internal_url":"https://www.academia.edu/122413149/P060_Effect_of_azacitidine_on_PI_PLC_beta1_expression_and_Akt_activation_in_a_patient_affected_by_high_risk_myelodysplastic_syndrome_MDS_","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413148"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413148/No_discrete_complexes_containing_DNA_polymerase_%CE%B1_activity_can_be_solubilized_from_the_heat_stabilized_nuclear_matrix_prepared_from_HeLa_S3_cells"><img alt="Research paper thumbnail of No discrete complexes containing DNA polymerase α activity can be solubilized from the heat-stabilized nuclear matrix prepared from HeLa S3 cells" class="work-thumbnail" src="https://attachments.academia-assets.com/117080901/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413148/No_discrete_complexes_containing_DNA_polymerase_%CE%B1_activity_can_be_solubilized_from_the_heat_stabilized_nuclear_matrix_prepared_from_HeLa_S3_cells">No discrete complexes containing DNA polymerase α activity can be solubilized from the heat-stabilized nuclear matrix prepared from HeLa S3 cells</a></div><div class="wp-workCard_item"><span>Cell Biochemistry and Function</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Most of the DNA polymerase a activity, bound to the heat-stabilized nuclear matrix prepared from ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Most of the DNA polymerase a activity, bound to the heat-stabilized nuclear matrix prepared from HeLa S3 cells, was released as a matrix extract by sonication. When the extract was centrifuged in a 5-20 per cent linear sucrose gradient no definite peaks of activity could be identified. Most of the activity sedimented to the bottom of the tube under all the conditions tested, whilst the remaining activity was associated with matrix fragments of various and irregular size. No 10 S complexes, containing polymerase activity, were seen after incubation of the extract for 16 h before centrifugation. Other solubilization procedures (i.e. treatment of the matrix with cheiating agents, high pH associated with reducing agents, ionic and nonionic detergents) failed to produce release of matrix-bound DNA polymerase a activity. In contrast, we released 10 S complexes, containing polymerase activity, from the matrix prepared from nuclei not exposed to heat. We conclude that a 37°C incubation of isolated nuclei before extraction with 2 M NaCl and DNase I digestion causes DNA polymerase a to bind to the nuclear matrix in a form that cannot subsequently be released as discrete components, at variance with previous results obtained with the matrix prepared from regenerating rat liver. KEY WORDS-Nuclear matrix; DNA polymerase a; soluble complexes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e82f46d8756ddb91be47c7fc756128d1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080901,"asset_id":122413148,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080901/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413148"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413148"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413148; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413148]").text(description); $(".js-view-count[data-work-id=122413148]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413148; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413148']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e82f46d8756ddb91be47c7fc756128d1" } } $('.js-work-strip[data-work-id=122413148]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413148,"title":"No discrete complexes containing DNA polymerase α activity can be solubilized from the heat-stabilized nuclear matrix prepared from HeLa S3 cells","internal_url":"https://www.academia.edu/122413148/No_discrete_complexes_containing_DNA_polymerase_%CE%B1_activity_can_be_solubilized_from_the_heat_stabilized_nuclear_matrix_prepared_from_HeLa_S3_cells","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080901,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080901/thumbnails/1.jpg","file_name":"cbf.29012010620240728-1-o397dk.pdf","download_url":"https://www.academia.edu/attachments/117080901/download_file","bulk_download_file_name":"No_discrete_complexes_containing_DNA_pol.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080901/cbf.29012010620240728-1-o397dk-libre.pdf?1722186004=\u0026response-content-disposition=attachment%3B+filename%3DNo_discrete_complexes_containing_DNA_pol.pdf\u0026Expires=1739787211\u0026Signature=HBycRKtykgvXVbaUA51KrVlBrB4sQSwivFHtZJJ7wQ7doYj9t4dlcBcM5RkpxvTVzdjEueit2flPX~jXoighxwfA0ysj3LLzuKbJI25nvtCCEmUKI9Ba8qo--b0JwG9G-We5ocCRa8uc0PnoXd7dyVTLEzVzTwuzIKYKs4RmzwgDOLmsIyZQGeb3jBHl9aU6EP0m671hc~~8mwv9ujmqc7mzikhO4LL25qEZEsX~z7sDiCumSL5rS1665UzLRqw8uPtb7qUbjZzpONtDe~kUBVXuAuhaOkom54CxDtlfcvVV2yV9qJ6ek6AIBFCkosGelXgdMI9ELkU0ZeAw1Joetg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413147"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413147/Temporal_changes_in_intracellular_distribution_of_protein_kinase_C_in_Swiss_3T3_cells_during_mitogenic_stimulation_with_insulin_like_growth_factor_I_and_bombesin_Translocation_to_the_nucleus_follows_rapid_changes_in_nuclear_polyphosphoinositides"><img alt="Research paper thumbnail of Temporal changes in intracellular distribution of protein kinase C in Swiss 3T3 cells during mitogenic stimulation with insulin-like growth factor I and bombesin: Translocation to the nucleus follows rapid changes in nuclear polyphosphoinositides" class="work-thumbnail" src="https://attachments.academia-assets.com/117080913/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413147/Temporal_changes_in_intracellular_distribution_of_protein_kinase_C_in_Swiss_3T3_cells_during_mitogenic_stimulation_with_insulin_like_growth_factor_I_and_bombesin_Translocation_to_the_nucleus_follows_rapid_changes_in_nuclear_polyphosphoinositides">Temporal changes in intracellular distribution of protein kinase C in Swiss 3T3 cells during mitogenic stimulation with insulin-like growth factor I and bombesin: Translocation to the nucleus follows rapid changes in nuclear polyphosphoinositides</a></div><div class="wp-workCard_item"><span>Biochemical and Biophysical Research Communications</span><span>, 1991</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f21cfaafbdbebb7f28872c3b335358c0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080913,"asset_id":122413147,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080913/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413147"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413147"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413147; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413147]").text(description); $(".js-view-count[data-work-id=122413147]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413147; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413147']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f21cfaafbdbebb7f28872c3b335358c0" } } $('.js-work-strip[data-work-id=122413147]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413147,"title":"Temporal changes in intracellular distribution of protein kinase C in Swiss 3T3 cells during mitogenic stimulation with insulin-like growth factor I and bombesin: Translocation to the nucleus follows rapid changes in nuclear polyphosphoinositides","internal_url":"https://www.academia.edu/122413147/Temporal_changes_in_intracellular_distribution_of_protein_kinase_C_in_Swiss_3T3_cells_during_mitogenic_stimulation_with_insulin_like_growth_factor_I_and_bombesin_Translocation_to_the_nucleus_follows_rapid_changes_in_nuclear_polyphosphoinositides","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080913,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080913/thumbnails/1.jpg","file_name":"0006-291x28912992009-920240728-1-9po9xj.pdf","download_url":"https://www.academia.edu/attachments/117080913/download_file","bulk_download_file_name":"Temporal_changes_in_intracellular_distri.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080913/0006-291x28912992009-920240728-1-9po9xj-libre.pdf?1722185999=\u0026response-content-disposition=attachment%3B+filename%3DTemporal_changes_in_intracellular_distri.pdf\u0026Expires=1739787211\u0026Signature=VQnk3toQ4Rb9~YBUSMt7wl6Sn5cQKzlQUkj-5yYQf0FcefvTNcYSLT2aiz3fJm7L931rtgtDIErFnQLnVJsZNdIhZNutYtUKvriACIU7uSLIafkI8LLfcqGRfr~OOtid-WhxCpTAp-vey4OeOdz~Dqh5~QYroOoiOxR6xp2hZv~xPvTTMhyVNNWZ8GdqD42nw5TMtBa9AZgIJI~q-0QNDTqiORwv7PoTUbBdU7RxW74h3QawHJurdJehAomJvX~h~8OTm64OmLzQVvMOF~aOjh9BLbDYEdaQWV9jKDWxsOgI12WqDnP9AVJmxLA0CubePA6UHpekyLBWa2n9o5Lf-Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413146"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413146/The_Protein_Kinase_Inhibitor_Staurosporine_Induces_Morphological_Changes_Typical_of_Apoptosis_in_MOLT_4_Cells_without_Concomitant_DNA_Fragmentation"><img alt="Research paper thumbnail of The Protein Kinase Inhibitor Staurosporine Induces Morphological Changes Typical of Apoptosis in MOLT-4 Cells without Concomitant DNA Fragmentation" class="work-thumbnail" src="https://attachments.academia-assets.com/117080900/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413146/The_Protein_Kinase_Inhibitor_Staurosporine_Induces_Morphological_Changes_Typical_of_Apoptosis_in_MOLT_4_Cells_without_Concomitant_DNA_Fragmentation">The Protein Kinase Inhibitor Staurosporine Induces Morphological Changes Typical of Apoptosis in MOLT-4 Cells without Concomitant DNA Fragmentation</a></div><div class="wp-workCard_item"><span>Biochemical and Biophysical Research Communications</span><span>, 1993</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4462b88c8971dd179e79bd215d58a21b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080900,"asset_id":122413146,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080900/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413146"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413146"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413146; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413146]").text(description); $(".js-view-count[data-work-id=122413146]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413146; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413146']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4462b88c8971dd179e79bd215d58a21b" } } $('.js-work-strip[data-work-id=122413146]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413146,"title":"The Protein Kinase Inhibitor Staurosporine Induces Morphological Changes Typical of Apoptosis in MOLT-4 Cells without Concomitant DNA Fragmentation","internal_url":"https://www.academia.edu/122413146/The_Protein_Kinase_Inhibitor_Staurosporine_Induces_Morphological_Changes_Typical_of_Apoptosis_in_MOLT_4_Cells_without_Concomitant_DNA_Fragmentation","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080900,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080900/thumbnails/1.jpg","file_name":"bbrc.1993.158420240728-1-vb5528.pdf","download_url":"https://www.academia.edu/attachments/117080900/download_file","bulk_download_file_name":"The_Protein_Kinase_Inhibitor_Staurospori.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080900/bbrc.1993.158420240728-1-vb5528-libre.pdf?1722185999=\u0026response-content-disposition=attachment%3B+filename%3DThe_Protein_Kinase_Inhibitor_Staurospori.pdf\u0026Expires=1739787211\u0026Signature=WVXlfnUtmqqI~CvSyIimX4VX6dKc0VfUXB6UThSQ4Op7kfSg34gnO5rt5wXOdBlQkA4vMp1RN3wUrDyRhx7cp6TNJVW3BDmkZeQhCDesbwJU9R71XNqeCa2Tv9WXUeEQyay-Na13mDc13x5AhaV2lu~LxgVh6wewCBQED8g2eodStT~RlvP896nSZey0T5Ntkmtuv9uT7XvAgg871OqJDsT5TmO3fAkms-TOxRsZwbRZvLjyG1MMAkYPlZwmbAItCqMLaVn0PqB4fyTEaj98t5tAmQBqPyiMEd~7sfiFVh39GDQ8pPlwlVUsdVnMt4RGQkO-Eh~nI~kPVjhXfGzc0A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413116"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413116/Inositide_specific_phospholipase_C_signalling_in_the_nucleus"><img alt="Research paper thumbnail of Inositide-specific phospholipase C signalling in the nucleus" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413116/Inositide_specific_phospholipase_C_signalling_in_the_nucleus">Inositide-specific phospholipase C signalling in the nucleus</a></div><div class="wp-workCard_item"><span>European Journal of Histochemistry</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The nucleus of eukaryotic cells contains all the information needed for cell proliferation and di...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The nucleus of eukaryotic cells contains all the information needed for cell proliferation and differentiation, however the initiation of these programmes are dependent on the signalling pathway elicited by different agonists. The existence of a nuclear phosphoinositide signalling stems from the early evidence that isolated nuclei posses the lipid kinases capable of phosphorylating phosphatidylinositol (PI) and phosphatidylinositol 4-phosphate (PIP). The synthesis of phosphatidylinositol 4,5- phosphate (PIP2) was clearly increased only in the nuclear fraction from Friend cells terminally differentiated towards erythrocytes (Cocco et al., 1987). On the contrary its amount along with that of PIP was decreased in nuclei of Swiss 3T3 cells stimulated to grow with insulin-like growth factor-I (IGFI) (Manzoli et al., 1989). Following these early observations we and others have demonstrated in several cell type the participation of the whole phosphoinositide cycle in the nucleus (Cocco et ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413116"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413116"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413116; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413116]").text(description); $(".js-view-count[data-work-id=122413116]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413116; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413116']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413116]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413116,"title":"Inositide-specific phospholipase C signalling in the nucleus","internal_url":"https://www.academia.edu/122413116/Inositide_specific_phospholipase_C_signalling_in_the_nucleus","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3128339" id="papers"><div class="js-work-strip profile--work_container" data-work-id="122413165"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413165/Proapoptotic_Activity_and_Chemosensitizing_Effect_of_the_Novel_Akt_Inhibitor_2_i_S_i_1_1_i_H_i_Indol_3_yl_3_5_3_methyl_2_i_H_i_indazol_5_yl_pyridin_3_yl_oxypropan2_amine_A443654_in_T_Cell_Acute_Lymphoblastic_Leukemia"><img alt="Research paper thumbnail of Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2<i>S</i>)-1-(1<i>H</i>-Indol-3-yl)-3-[5-(3-methyl-2<i>H</i>-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia" class="work-thumbnail" src="https://attachments.academia-assets.com/117080865/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413165/Proapoptotic_Activity_and_Chemosensitizing_Effect_of_the_Novel_Akt_Inhibitor_2_i_S_i_1_1_i_H_i_Indol_3_yl_3_5_3_methyl_2_i_H_i_indazol_5_yl_pyridin_3_yl_oxypropan2_amine_A443654_in_T_Cell_Acute_Lymphoblastic_Leukemia">Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2<i>S</i>)-1-(1<i>H</i>-Indol-3-yl)-3-[5-(3-methyl-2<i>H</i>-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia</a></div><div class="wp-workCard_item"><span>Molecular Pharmacology</span><span>, Jun 24, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Constitutively activated AKT kinase is a common feature of T-cell acute lymphoblastic leukemia (T...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Constitutively activated AKT kinase is a common feature of T-cell acute lymphoblastic leukemia (T-ALL). Here, we report that the novel AKT inhibitor (2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2Hindazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) leads to rapid cell death of TALL lines and patient samples. Treatment of CEM, Jurkat, and MOLT-4 cells with nanomolar doses of the inhibitor led to AKT phosphorylation accompanied by dephosphorylation and activation of the downstream target, glycogen synthase kinase-3β. Effects were time-and dose-dependent, resulting in apoptotic cell death. Treatment of Jurkat cells with A443654 resulted in activation of caspase-2,-3,-6,-8, and-9. Apoptotic cell death was mostly dependent on caspase-2 activation, as demonstrated by preincubation with a selective pharmacological inhibitor. It is remarkable that A443654 was highly effective against the drug-resistant cell line CEMVBL100, which expresses 170-kDa P-glycoprotein. Moreover, A443654 synergized with the DNA-damaging agent etoposide in both drug-sensitive and drug-resistant cell lines when coadministered [combination index (CI) = 0.39] or when pretreated with etoposide followed by A443654 (CI = 0.689). The efficacy of A443654 was confirmed using blasts from six patients with TALL , all of whom displayed low levels of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and constitutive phosphorylation of Akt on Ser473. At 1 μM, the inhibitor was able to induce apoptotic cell death of TALL blast cells, as indicated by flow cytometric analysis of samples immunostained for active (cleaved) caspase-3. Because activated AKT is seen in a large percentage of patients with TALL , A443654, either alone or in combination with existing drugs, may be a useful therapy for primary and drug-resistant TALL .</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1b5cee3609ac4ec78adf8a3884f5183e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080865,"asset_id":122413165,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080865/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413165"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413165"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413165; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413165]").text(description); $(".js-view-count[data-work-id=122413165]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413165; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413165']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1b5cee3609ac4ec78adf8a3884f5183e" } } $('.js-work-strip[data-work-id=122413165]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413165,"title":"Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2\u003ci\u003eS\u003c/i\u003e)-1-(1\u003ci\u003eH\u003c/i\u003e-Indol-3-yl)-3-[5-(3-methyl-2\u003ci\u003eH\u003c/i\u003e-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia","internal_url":"https://www.academia.edu/122413165/Proapoptotic_Activity_and_Chemosensitizing_Effect_of_the_Novel_Akt_Inhibitor_2_i_S_i_1_1_i_H_i_Indol_3_yl_3_5_3_methyl_2_i_H_i_indazol_5_yl_pyridin_3_yl_oxypropan2_amine_A443654_in_T_Cell_Acute_Lymphoblastic_Leukemia","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080865,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080865/thumbnails/1.jpg","file_name":"pmc2659779.pdf","download_url":"https://www.academia.edu/attachments/117080865/download_file","bulk_download_file_name":"Proapoptotic_Activity_and_Chemosensitizi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080865/pmc2659779-libre.pdf?1722186016=\u0026response-content-disposition=attachment%3B+filename%3DProapoptotic_Activity_and_Chemosensitizi.pdf\u0026Expires=1739787211\u0026Signature=fZveLgxnWrWuyAZyRen3SoqUleTSa-~qucbfUHqpPhUqRYKGLVuZyvx02OkEaMG8lx4xDQmAZmCdbuEcjzVrZgQ1fjrDSZRB-rfCUCf98x4gTUif6hu6UT8m4JPJUy5Z4fi-4mmKWZxOgzqPmDch6m9jdMKkALVluNmLUL07AyAKPQENb3T0xv9ZwaT4v34fYk3en0TkHfoE2zp1koVwHrEoqmjHzPhzyqb2A~Ti2O5exT27-MODvKJIp4QZi-y5UNN4uNt3ohB2t8Kc8rI~j0UZ-2U0OrXhJbRXOQrwgJG8-u4X8qQDJ9I7mX7IOs3xjRs7RL1VUBtUdroBHHI34Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":117080864,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080864/thumbnails/1.jpg","file_name":"pmc2659779.pdf","download_url":"https://www.academia.edu/attachments/117080864/download_file","bulk_download_file_name":"Proapoptotic_Activity_and_Chemosensitizi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080864/pmc2659779-libre.pdf?1722186015=\u0026response-content-disposition=attachment%3B+filename%3DProapoptotic_Activity_and_Chemosensitizi.pdf\u0026Expires=1739787211\u0026Signature=aFEFLxufzBzxkuiyXXveN8Pi0ha-xHS6V72dceaf8GkY7sANtGEgqq7IeZ9F9iLKrsnJQdbK9yi1FPRCkiPoINC3J99QjkmDZv-Uo7D6vYi6OkzEyL-wULPImBHvpLDjWGiVLlD16je0LLn2Br6QAzMA9rwZiGBNBieiJzS9VTyenvt4OZdgKFCn1Wu3~32ORdd3HqnXQPwvm6fDaqPngmWNrVhspFg9WO6FImen9nAEaR7vJqBEkBPkl2ZK6spAn93uw-DMhSrW-de31DTUxVPCXs-y1X45MPvI30xY3btLQArq1YipMlL1xy41mndrI8W6SoKKSFAK~buOH7vppw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413164"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413164/Supplementary_Figure_1_from_Synergistic_Proapoptotic_Activity_of_Recombinant_TRAIL_Plus_the_Akt_Inhibitor_Perifosine_in_Acute_Myelogenous_Leukemia_Cells"><img alt="Research paper thumbnail of Supplementary Figure 1 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/117080863/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413164/Supplementary_Figure_1_from_Synergistic_Proapoptotic_Activity_of_Recombinant_TRAIL_Plus_the_Akt_Inhibitor_Perifosine_in_Acute_Myelogenous_Leukemia_Cells">Supplementary Figure 1 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="61afcc18ee9528dd9d134a557b5cf249" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080863,"asset_id":122413164,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080863/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413164"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413164"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413164; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413164]").text(description); $(".js-view-count[data-work-id=122413164]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413164; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413164']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "61afcc18ee9528dd9d134a557b5cf249" } } $('.js-work-strip[data-work-id=122413164]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413164,"title":"Supplementary Figure 1 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells","internal_url":"https://www.academia.edu/122413164/Supplementary_Figure_1_from_Synergistic_Proapoptotic_Activity_of_Recombinant_TRAIL_Plus_the_Akt_Inhibitor_Perifosine_in_Acute_Myelogenous_Leukemia_Cells","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080863,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080863/thumbnails/1.jpg","file_name":"39820943.pdf","download_url":"https://www.academia.edu/attachments/117080863/download_file","bulk_download_file_name":"Supplementary_Figure_1_from_Synergistic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080863/39820943-libre.pdf?1722186011=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_1_from_Synergistic.pdf\u0026Expires=1739787211\u0026Signature=Wj5hPA9cYhaj8a9UEB4y0yKXb2FWRcCr4QW-1D2UN-a497cbpuUKVhlIwIuB6DHIadc7Mtwslxa58eS7meaSH6EAprxUOtsGbtKf0Kg7QLrKiQIdlWc3hA5u~WLD718-GH5yGeQTpajBG~ILveizRw7kR7xThwnT5KnrGPAJUt0ojMEO~24POVGqTqwB5Sz4nltkSJmokJla90xm7eb5wvEfa1qJ7DL~6S~acNuSOI74SV~I5qfr25ZgRCkcfUO98~VO2pIkAdTaJyWeuCirZQHTNmrFhqvDT4gX4WbXgvsX0iHgLS8jBetU-0lbiVoQn9w1s3SmzO1-JE6LOL4aJA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":117080862,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080862/thumbnails/1.jpg","file_name":"39820943.pdf","download_url":"https://www.academia.edu/attachments/117080862/download_file","bulk_download_file_name":"Supplementary_Figure_1_from_Synergistic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080862/39820943-libre.pdf?1722186012=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_1_from_Synergistic.pdf\u0026Expires=1739787211\u0026Signature=PbOSJ4j6QZ5uuROr6xZWbT-Kb~pxVhaBVZqf2EqDHaeYrPwJCa9TS2GC6rnrWGhzIU7ONvAhfCI~IZGk5OfgrTbuWU6SbmP8m4ZbRB9AsfCNVQLQyyeH9cZ0Hwbi1LnJBMRCQDk2ldrw4FKLUAOa21jCGg8WcPbbKkdRHclES2npB7zGQxWdhDb9B5A4cHCztRsEwR0c1PKTW1~xoeCk5~hklR1TU6M3GbRpT3hPmOlAWYeDm13sCPp5Xtbyc20v3lLJGEfDMfY~8-pV8Zr8sOOAzJzvgeTip-oKY-h56tbfe4g5AYuGhd1hE2ZowMt3976E3DwKBTMQ-h18RRPwHQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413163"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413163/Supplementary_Figure_2_from_Synergistic_Proapoptotic_Activity_of_Recombinant_TRAIL_Plus_the_Akt_Inhibitor_Perifosine_in_Acute_Myelogenous_Leukemia_Cells"><img alt="Research paper thumbnail of Supplementary Figure 2 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/117080909/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413163/Supplementary_Figure_2_from_Synergistic_Proapoptotic_Activity_of_Recombinant_TRAIL_Plus_the_Akt_Inhibitor_Perifosine_in_Acute_Myelogenous_Leukemia_Cells">Supplementary Figure 2 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dcc60a62efce522f3e41edc33a606b0d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080909,"asset_id":122413163,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080909/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413163"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413163"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413163; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413163]").text(description); $(".js-view-count[data-work-id=122413163]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413163; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413163']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dcc60a62efce522f3e41edc33a606b0d" } } $('.js-work-strip[data-work-id=122413163]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413163,"title":"Supplementary Figure 2 from Synergistic Proapoptotic Activity of Recombinant TRAIL Plus the Akt Inhibitor Perifosine in Acute Myelogenous Leukemia Cells","internal_url":"https://www.academia.edu/122413163/Supplementary_Figure_2_from_Synergistic_Proapoptotic_Activity_of_Recombinant_TRAIL_Plus_the_Akt_Inhibitor_Perifosine_in_Acute_Myelogenous_Leukemia_Cells","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080909,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080909/thumbnails/1.jpg","file_name":"39820940.pdf","download_url":"https://www.academia.edu/attachments/117080909/download_file","bulk_download_file_name":"Supplementary_Figure_2_from_Synergistic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080909/39820940-libre.pdf?1722185998=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_2_from_Synergistic.pdf\u0026Expires=1739787211\u0026Signature=fVKPjpO6x2Md2GUs7ZPGqh5kmDpEDMNkOeabxLZgS1wCAjnVoPQKow0nGRWsJVELskUwIKQJuhMAuTXLDXsTxJHXJz~6iUNjSdZ7A9rHDIBGIYsWBij6XOqZ93oK~u5Ha0geimgcQ5vtPnFa0AHLri9CKf8mfifkaG5FlsZ4uU0znlUS-myeUrqxtwRx8LK7rge6jtvkndN7rQLGCjgiujRb8pQ~BxGP~hjCnJs9o5KaeNKK3KJ4zoXp6GuHRMyi6yVjS5bRJd~PGTCrfu0~5Pp~ziIa6kTi7lyxge7UhJyrvm~PrmJyq6BJMdffG6EiK9AYKZOaScFwRriLXtNk4A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413162"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413162/Supplementary_Figure_S2_from_Prospective_Phase_II_Study_on_5_Days_Azacitidine_for_Treatment_of_Symptomatic_and_or_Erythropoietin_Unresponsive_Patients_with_Low_INT_1_Risk_Myelodysplastic_Syndromes"><img alt="Research paper thumbnail of Supplementary Figure S2 from Prospective Phase II Study on 5-Days Azacitidine for Treatment of Symptomatic and/or Erythropoietin Unresponsive Patients with Low/INT-1–Risk Myelodysplastic Syndromes" class="work-thumbnail" src="https://attachments.academia-assets.com/117080905/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413162/Supplementary_Figure_S2_from_Prospective_Phase_II_Study_on_5_Days_Azacitidine_for_Treatment_of_Symptomatic_and_or_Erythropoietin_Unresponsive_Patients_with_Low_INT_1_Risk_Myelodysplastic_Syndromes">Supplementary Figure S2 from Prospective Phase II Study on 5-Days Azacitidine for Treatment of Symptomatic and/or Erythropoietin Unresponsive Patients with Low/INT-1–Risk Myelodysplastic Syndromes</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Supplementary Figure S2 - PDF file 145K, Representation from Chromosome Analysis Suite (Chas, Aff...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Supplementary Figure S2 - PDF file 145K, Representation from Chromosome Analysis Suite (Chas, Affymetrix) of LOH alterations in analyzed MDS patients.The figure represents the LOH of the 5 patients with this abnormality and shows its distribution and its size within the chromosomes</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="971b4f13e11bf84cff8ed51a7b09c1f9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080905,"asset_id":122413162,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080905/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413162"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413162"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413162; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413162]").text(description); $(".js-view-count[data-work-id=122413162]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413162; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413162']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "971b4f13e11bf84cff8ed51a7b09c1f9" } } $('.js-work-strip[data-work-id=122413162]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413162,"title":"Supplementary Figure S2 from Prospective Phase II Study on 5-Days Azacitidine for Treatment of Symptomatic and/or Erythropoietin Unresponsive Patients with Low/INT-1–Risk Myelodysplastic Syndromes","internal_url":"https://www.academia.edu/122413162/Supplementary_Figure_S2_from_Prospective_Phase_II_Study_on_5_Days_Azacitidine_for_Treatment_of_Symptomatic_and_or_Erythropoietin_Unresponsive_Patients_with_Low_INT_1_Risk_Myelodysplastic_Syndromes","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080905/thumbnails/1.jpg","file_name":"39898256.pdf","download_url":"https://www.academia.edu/attachments/117080905/download_file","bulk_download_file_name":"Supplementary_Figure_S2_from_Prospective.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080905/39898256-libre.pdf?1722185998=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Figure_S2_from_Prospective.pdf\u0026Expires=1739787211\u0026Signature=UZrb11au1MUiXnMWDWkkw8rEA3ZMNWLqL8tiScXrglipGRpFdqcm3T1GctDQkMUciQG07ijaFSSrlxtiKuMJH7hVxF-wVdo1SaX-vlkg0TVj4AAzbYCZl1StN00-uVWRUH4hVoNqmkzDziL74QxrQqwGlkZP~a4TQ8P6NlQti-KixpZvm1FABwmsKrzn6HfW-uM4VfL4ssenRSlb9N5LJCeCwe5F-uWNo2Gy0~-2ze7z7~9PAdjWoebj4FLiFSiahvdvrv~dsCCac0ML2Iz1UzutV5mRghe9gryDvOU1bGhmwORpHJ6PGQ8CovBhiCwHsxxZK4MXAyzvJj2BZ8P-1A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413161"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413161/Supplementary_Table_S1_from_Prospective_Phase_II_Study_on_5_Days_Azacitidine_for_Treatment_of_Symptomatic_and_or_Erythropoietin_Unresponsive_Patients_with_Low_INT_1_Risk_Myelodysplastic_Syndromes"><img alt="Research paper thumbnail of Supplementary Table S1 from Prospective Phase II Study on 5-Days Azacitidine for Treatment of Symptomatic and/or Erythropoietin Unresponsive Patients with Low/INT-1–Risk Myelodysplastic Syndromes" class="work-thumbnail" src="https://attachments.academia-assets.com/117080906/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413161/Supplementary_Table_S1_from_Prospective_Phase_II_Study_on_5_Days_Azacitidine_for_Treatment_of_Symptomatic_and_or_Erythropoietin_Unresponsive_Patients_with_Low_INT_1_Risk_Myelodysplastic_Syndromes">Supplementary Table S1 from Prospective Phase II Study on 5-Days Azacitidine for Treatment of Symptomatic and/or Erythropoietin Unresponsive Patients with Low/INT-1–Risk Myelodysplastic Syndromes</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Supplementary Table S1 - PDF file 69K, Summary of macroscopic CNAs and LOH alterations identified...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Supplementary Table S1 - PDF file 69K, Summary of macroscopic CNAs and LOH alterations identified in MDS patients and response to fourth cycle of 5d-Aza. The table summarizes the results of SNP karyotyping, LOH and CNAs in the 26 MDS patients for whom the an</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="735856e346e56fccf8c43621d69eea29" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080906,"asset_id":122413161,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080906/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413161"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413161"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413161; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413161]").text(description); $(".js-view-count[data-work-id=122413161]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413161; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413161']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "735856e346e56fccf8c43621d69eea29" } } $('.js-work-strip[data-work-id=122413161]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413161,"title":"Supplementary Table S1 from Prospective Phase II Study on 5-Days Azacitidine for Treatment of Symptomatic and/or Erythropoietin Unresponsive Patients with Low/INT-1–Risk Myelodysplastic Syndromes","internal_url":"https://www.academia.edu/122413161/Supplementary_Table_S1_from_Prospective_Phase_II_Study_on_5_Days_Azacitidine_for_Treatment_of_Symptomatic_and_or_Erythropoietin_Unresponsive_Patients_with_Low_INT_1_Risk_Myelodysplastic_Syndromes","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080906,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080906/thumbnails/1.jpg","file_name":"39898253.pdf","download_url":"https://www.academia.edu/attachments/117080906/download_file","bulk_download_file_name":"Supplementary_Table_S1_from_Prospective.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080906/39898253-libre.pdf?1722185997=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Table_S1_from_Prospective.pdf\u0026Expires=1739787211\u0026Signature=Icqd8-lOYUY7cq7bFirFJ9~DL8hxcXdRiAEmnMgOK1XIme-oHJjG4E9Jx6kIBTJ-eDXS9U2JKWoCdWyfFJ5D6Vb4Cv~uzMgli4ML67GEgHQ9q9uVLDmguv0URsRad7BEB6GFjYFmWDXcddQhXxbgnHWR2s8jI2SMhzEiHaBfKxqXME6iJ4QbWmjJOMv1KuTSfE6ByJ5CVGNLRzgPGtMnQPtV6kHz1fZOx6FA2NElrFqesKQvlQPMn138BiTa-9RMibod-HPNj0K6Vfw5E9XaK8vCfsewbWMkaUzzb2s9vVIk4oLOqv31AXidCRHeRCw7rTnRPuclGn28azpnMV-3Aw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413160"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413160/BMP_2_induced_expression_of_PLC_beta1_that_is_a_positive_regulator_of_osteoblast_differentiation"><img alt="Research paper thumbnail of BMP-2 induced expression of PLC beta1 that is a positive regulator of osteoblast differentiation" class="work-thumbnail" src="https://attachments.academia-assets.com/117080907/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413160/BMP_2_induced_expression_of_PLC_beta1_that_is_a_positive_regulator_of_osteoblast_differentiation">BMP-2 induced expression of PLC beta1 that is a positive regulator of osteoblast differentiation</a></div><div class="wp-workCard_item"><span>Italian journal of anatomy and embryology</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">C2C12 is an immortalized mouse myoblast cell line. The cells readily proliferate in high-serum co...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">C2C12 is an immortalized mouse myoblast cell line. The cells readily proliferate in high-serum conditions, and differentiate and fuse in low-serum conditions. While this cell line is a very useful tool to study aspects of myogenesis, metabolism and muscle biology, however, treatment of C2C12 cells with bone morphogenic protein (BMPs) induces cells to differentiate into osteoblasts. Osteoblast differentiation is controlled by diversified signaling proteins and transcription factors, essentially BMP-2, Osterix (Osx/Sp7) and Runx2, finally associating with the expression of late osteoblast marker genes, like ALPL and Bglap. These peculiarities make C2C12 progenitor cells a skillful prototype to investigate the molecular mechanism that control cell destiny specification and terminal differentiation. In the current investigation, we took improvement of the differentiation peculiarities of the mouse C2C12 cell line to analyze whether changes in PLCbeta1 expression and its nuclear localiza...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="114c41b05da915c2f13c478c11379e29" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080907,"asset_id":122413160,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080907/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413160"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413160"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413160; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413160]").text(description); $(".js-view-count[data-work-id=122413160]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413160; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413160']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "114c41b05da915c2f13c478c11379e29" } } $('.js-work-strip[data-work-id=122413160]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413160,"title":"BMP-2 induced expression of PLC beta1 that is a positive regulator of osteoblast differentiation","internal_url":"https://www.academia.edu/122413160/BMP_2_induced_expression_of_PLC_beta1_that_is_a_positive_regulator_of_osteoblast_differentiation","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080907,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080907/thumbnails/1.jpg","file_name":"228555143.pdf","download_url":"https://www.academia.edu/attachments/117080907/download_file","bulk_download_file_name":"BMP_2_induced_expression_of_PLC_beta1_th.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080907/228555143-libre.pdf?1722185999=\u0026response-content-disposition=attachment%3B+filename%3DBMP_2_induced_expression_of_PLC_beta1_th.pdf\u0026Expires=1739787211\u0026Signature=NvR6gLnHxvfdvHX2o9Et0UlrhaOaYduENRsVCL7x8xyAvdJN6djKE62UDrjBD5RqmqL7Z92UNyn9fB~tSRpCsBxvwSoN04eMcV7sHK8qMxZrUtzlzU4bdNm6XchjUx0AE1lACMU2FJpNJC2oSth7tzgUIboEmWtupUB-k1rxcQLwGdvvFz8YiCEsHoRKH14GiGXr-GvCQbFBtaocBDq-5S13Wv8dOF0CIfX4ryJT9U2r9TfUH9NnKrV~BLnPNW8mfcLRMWrU77coDkH88NbH86gevW2Faj8psN4yWM8Qqw85HLgSHfQLiAuh81WQBTm~7zo~7latIzijtsQQwvO4lg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413159"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413159/Cancer_therapy_and_treatments_during_COVID_19_era"><img alt="Research paper thumbnail of Cancer therapy and treatments during COVID-19 era" class="work-thumbnail" src="https://attachments.academia-assets.com/117080912/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413159/Cancer_therapy_and_treatments_during_COVID_19_era">Cancer therapy and treatments during COVID-19 era</a></div><div class="wp-workCard_item"><span>Advances in Biological Regulation</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The COVID-19 pandemic has put a serious strain on health treatments as well at the economies of m...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The COVID-19 pandemic has put a serious strain on health treatments as well at the economies of many nations. Unfortunately, there is not currently available vaccine for SARS-Cov-2/COVID-19. Various types of patients have delayed treatment or even routine checkups and we are adapting to a virtual world. In many cases, surgeries are delayed unless they are essential. This is also true with regards to cancer treatments and screening. Interestingly, some existing drugs and nutraceuticals have been screened for their effects on COVID-19. Certain FDA approved drugs, vitamin, natural products and trace minerals may be repurposed to treat or improve the prevention of COVID-19 infections and disease progression. This review article will summarize how the treatments of various cancer patients has changed during the COVID-19 era as well as discuss the promise of some existing drugs and other agents to be repurposed to treat this disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b148fb9f15b39e4495c1044e6b40e3b1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080912,"asset_id":122413159,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080912/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413159"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413159"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413159; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413159]").text(description); $(".js-view-count[data-work-id=122413159]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413159; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413159']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b148fb9f15b39e4495c1044e6b40e3b1" } } $('.js-work-strip[data-work-id=122413159]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413159,"title":"Cancer therapy and treatments during COVID-19 era","internal_url":"https://www.academia.edu/122413159/Cancer_therapy_and_treatments_during_COVID_19_era","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080912,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080912/thumbnails/1.jpg","file_name":"ptpmcrender.pdf","download_url":"https://www.academia.edu/attachments/117080912/download_file","bulk_download_file_name":"Cancer_therapy_and_treatments_during_COV.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080912/ptpmcrender-libre.pdf?1722186026=\u0026response-content-disposition=attachment%3B+filename%3DCancer_therapy_and_treatments_during_COV.pdf\u0026Expires=1739787211\u0026Signature=KMkBN~1Drl1nX4pURIps97yYiOY1AnF5a47eCnkGERcFpuvJT-hRnSPX5O31diYr73Jsmyu59~uKgXkO4Djrbp5Zl9MJ3qPmNaRN3m0eXP06jXIzWUvqWfHcyHmvzfMpe5k~E~ooKbVOEpH-GgMXKw5a96ybVngQcaPETyKEawmA-Bv4rei7wY4fUuf1vAIZrPWq2s3VYP9LJKCnv8Yz8Td2rp7GaQTAzlf89bxfd0FZxsFm6HfmWXVgf~1RCbgMtXvQvAmjTg5L6-NqBP84E3Z9mLTOMOujIOT~G1JXp5i0tvHVXpQoO2B9~mtfhqpB7NzRc-8jfzubYpPY5ZNFCw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413158"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413158/The_function_of_PLC%CE%B31_in_developing_mouse_mDA_system"><img alt="Research paper thumbnail of The function of PLCγ1 in developing mouse mDA system" class="work-thumbnail" src="https://attachments.academia-assets.com/117080904/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413158/The_function_of_PLC%CE%B31_in_developing_mouse_mDA_system">The function of PLCγ1 in developing mouse mDA system</a></div><div class="wp-workCard_item"><span>Advances in Biological Regulation</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">During neural development, growing neuronal cells consistently sense and communicate with their s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">During neural development, growing neuronal cells consistently sense and communicate with their surroundings through the use of signaling molecules. In this process, spatiotemporally wellcoordinated intracellular signaling is a prerequisite for proper neuronal network formation. Thus, intense interest has focused on investigating the signaling mechanisms in neuronal structure formation that link the activation of receptors to the control of cell shape and motility. Recent studies suggest that Phospholipase C gamma1 (PLCγ1), a signal transducer, plays key roles in nervous system development by mediating specific ligand-receptor systems. In this overview of the most recent advances in the field, we discuss the mechanisms by which extracellular stimuli trigger PLCγ1 signaling and, the role PLCγ1 in nervous system development.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="740d288b4d698802a3e13d3d01c4da2d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080904,"asset_id":122413158,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080904/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413158"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413158"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413158; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413158]").text(description); $(".js-view-count[data-work-id=122413158]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413158; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413158']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "740d288b4d698802a3e13d3d01c4da2d" } } $('.js-work-strip[data-work-id=122413158]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413158,"title":"The function of PLCγ1 in developing mouse mDA system","internal_url":"https://www.academia.edu/122413158/The_function_of_PLC%CE%B31_in_developing_mouse_mDA_system","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080904,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080904/thumbnails/1.jpg","file_name":"j.jbior.2019.10065420240728-1-hq91pt.pdf","download_url":"https://www.academia.edu/attachments/117080904/download_file","bulk_download_file_name":"The_function_of_PLC1_in_developing_mous.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080904/j.jbior.2019.10065420240728-1-hq91pt-libre.pdf?1722186000=\u0026response-content-disposition=attachment%3B+filename%3DThe_function_of_PLC1_in_developing_mous.pdf\u0026Expires=1739787211\u0026Signature=PL3eVHqMYaPMd5FMMISb~C7IJBEpRhA48kIBlgfLA7YWB5bYegSzwNKLW2VC7GsnBVoCfuUQTKWJmI3DmurZZzpy2MksniGQ8U1DLbeNbC4oMTBU~VtFIYHXA4Qm1rgkq33XGy~vgjffP891ASV6bUvOazCNFbmzEKCCbh5rEjIwCPm0Kq-yiNqhuJxCz4I8S1U918qJSGoeoLla6qhBXasDShSi6BSH0eIt~DCEbkYO9aobNXvS659qIL2w5p3ub0Et84cN9YkJEWm8oOX30jGTfjVHMOLTkha3TKCorw9UnRogzWHNyNJNyXVaoh382kq7Xk~sKMdDkWNTUpHdxQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413157"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413157/Anatomical_variations_of_the_right_renal_and_spermatic_arteries_a_case_report"><img alt="Research paper thumbnail of Anatomical variations of the right renal and spermatic arteries: a case report" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413157/Anatomical_variations_of_the_right_renal_and_spermatic_arteries_a_case_report">Anatomical variations of the right renal and spermatic arteries: a case report</a></div><div class="wp-workCard_item"><span>Italian journal of anatomy and embryology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Knowledge of the anatomy of renal vessels and their anatomical variations (diverse branching from...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Knowledge of the anatomy of renal vessels and their anatomical variations (diverse branching from abdominal aorta) represents an indispensable moment for planning and performing surgical operations in this area. Renal arteries originate from abdominal aorta at L1-L2 level. Normally the right renal artery passes behind inferior vena cava and right renal vein, the left one is shorter and passes behind left renal vein. Each renal artery gives inferior adrenal gland arteries and divides in four or five branches close to the hilum. Usually, shortly below the right renal artery, right gonadic artery arises and runs in front of the inferior vena cava. In our Department, during a routine gross anatomy dissection of a 98-year-old Caucasian male cadaver for undergraduated, postgraduated students and residents, we observed that right renal artery exhibit an early bifurcation. The two arteries have a peculiar running, in spite of the more frequent behavior. They cross each other at the middle of the path between abdominal aorta and renal hilum forming a sort of knot. The lower branch goes up looking like a superior polar artery, from which stems a short retropielic artery. Right gonadic artery originates from right renal artery in spite of its more frequent origin from abdominal aorta at L3 level. These monolateral variations are of course unusual but not responsible for any hemodynamic impairment. Probably as concerning the right renal artery variation it looks like that it is due to a non complete fusion of the primitive segmental arteries at the first steps of formation of right dorsalis aorta. This impinges on the fact that also the right gonadic artery stays close to the upper part of dorsalis aorta and therefore originates eventually from the right renal artery.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413157"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413157"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413157; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413157]").text(description); $(".js-view-count[data-work-id=122413157]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413157; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413157']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413157]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413157,"title":"Anatomical variations of the right renal and spermatic arteries: a case report","internal_url":"https://www.academia.edu/122413157/Anatomical_variations_of_the_right_renal_and_spermatic_arteries_a_case_report","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413156"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413156/Modulation_of_nuclear_PI_PLCbeta1_during_cell_differentiation"><img alt="Research paper thumbnail of Modulation of nuclear PI-PLCbeta1 during cell differentiation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413156/Modulation_of_nuclear_PI_PLCbeta1_during_cell_differentiation">Modulation of nuclear PI-PLCbeta1 during cell differentiation</a></div><div class="wp-workCard_item"><span>Advances in biological regulation</span><span>, Jan 26, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">PI-PLCbeta1 plays an important role in cell differentiation, and particularly in myogenesis, oste...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">PI-PLCbeta1 plays an important role in cell differentiation, and particularly in myogenesis, osteogenesis and hematopoiesis. Indeed, the increase of PI-PLCbeta1, along with Cyclin D3, has been detected in C2C12 mouse myoblasts induced to differentiate, as well as in human cells obtained from myotonic dystrophy. Also in the case of osteogenic differentiation there is a specific induction of PI-PLCbeta1, but in this case the role of PI-PLCbeta1 seems to be independent from Cyclin D3, so that a different mechanism could be involved. As for the hematopoietic system, PI-PLCbeta1 has a peculiar behavior: it increases during myeloid differentiation and decreases during erythroid differentiation, thus confirming the role of PI-PLCbeta1 as a modulator of hematopoiesis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413156"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413156"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413156; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413156]").text(description); $(".js-view-count[data-work-id=122413156]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413156; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413156']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413156]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413156,"title":"Modulation of nuclear PI-PLCbeta1 during cell differentiation","internal_url":"https://www.academia.edu/122413156/Modulation_of_nuclear_PI_PLCbeta1_during_cell_differentiation","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413154"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413154/Roles_of_EGFR_and_KRAS_and_their_downstream_signaling_pathways_in_pancreatic_cancer_and_pancreatic_cancer_stem_cells"><img alt="Research paper thumbnail of Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413154/Roles_of_EGFR_and_KRAS_and_their_downstream_signaling_pathways_in_pancreatic_cancer_and_pancreatic_cancer_stem_cells">Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells</a></div><div class="wp-workCard_item"><span>Advances in Biological Regulation</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Pancreatic cancer is currently the fourth most common cancer, is increasing in incidence and soon...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Pancreatic cancer is currently the fourth most common cancer, is increasing in incidence and soon will be the second leading cause of cancer death in the USA. This is a deadly malignancy with an incidence that approximates the mortality with 44,000 new cases and 36,000 deaths each year. Surgery, although only modestly successful, is the only curative option. However, due the locally aggressive nature and early metastasis, surgery can be performed on less than 20% of patients. Cytotoxic chemotherapy is palliative, has significant toxicity and improves survival very little. Thus new treatment paradigms are needed desperately. Due to the extremely high frequency of KRAS gene mutations (&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;90%) detected in pancreatic cancer patients, the roles of the epidermal growth factor receptor (EGFR), Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTORC1/GSK-3 pathways have been investigated in pancreatic cancer for many years. Constitutively active Ras can activate both of these pathways and there is cross talk between Ras and EGFR which is believed to be important in driving metastasis. Mutant KRAS may also drive the expression of GSK-3 through Raf/MEK/ERK-mediated effects on GSK-3 transcription. GSK-3 can then regulate the expression of NF-kappaB which is important in modulating pancreatic cancer chemoresistance. While the receptors and many downstream signaling molecules have been identified and characterized, there is still much to learn about these pathways and how their deregulation can lead to cancer. Multiple inhibitors to EGFR, PI3K, mTOR, GSK-3, Raf, MEK and hedgehog (HH) have been developed and are being evaluated in various cancers. Current research often focuses on the role of these pathways in cancer stem cells (CSC), with the goal to identify sites where therapeutic resistance may develop. Relatively novel fields of investigation such as microRNAs and drugs used for other diseases e.g., diabetes, (metformin) and malaria (chloroquine) have provided new information about therapeutic resistance and CSCs. This review will focus on recent advances in the field and how they affect pancreatic cancer research and treatment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413154"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413154"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413154; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413154]").text(description); $(".js-view-count[data-work-id=122413154]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413154; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413154']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413154]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413154,"title":"Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells","internal_url":"https://www.academia.edu/122413154/Roles_of_EGFR_and_KRAS_and_their_downstream_signaling_pathways_in_pancreatic_cancer_and_pancreatic_cancer_stem_cells","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413153"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413153/Nuclear_lipids_in_friend_cells_Shifted_profile_of_diacylglycerol_during_erythroid_differentiation_induced_by_DMSO"><img alt="Research paper thumbnail of Nuclear lipids in friend cells. Shifted profile of diacylglycerol during erythroid differentiation induced by DMSO" class="work-thumbnail" src="https://attachments.academia-assets.com/117080902/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413153/Nuclear_lipids_in_friend_cells_Shifted_profile_of_diacylglycerol_during_erythroid_differentiation_induced_by_DMSO">Nuclear lipids in friend cells. Shifted profile of diacylglycerol during erythroid differentiation induced by DMSO</a></div><div class="wp-workCard_item"><span>Cell Biology International Reports</span><span>, 1990</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="18f265a06c036705d9f600c39dde3bff" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080902,"asset_id":122413153,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080902/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413153"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413153"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413153; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413153]").text(description); $(".js-view-count[data-work-id=122413153]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413153; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413153']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "18f265a06c036705d9f600c39dde3bff" } } $('.js-work-strip[data-work-id=122413153]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413153,"title":"Nuclear lipids in friend cells. Shifted profile of diacylglycerol during erythroid differentiation induced by DMSO","internal_url":"https://www.academia.edu/122413153/Nuclear_lipids_in_friend_cells_Shifted_profile_of_diacylglycerol_during_erythroid_differentiation_induced_by_DMSO","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080902,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080902/thumbnails/1.jpg","file_name":"0309-165128902991183-520240728-1-4myabx.pdf","download_url":"https://www.academia.edu/attachments/117080902/download_file","bulk_download_file_name":"Nuclear_lipids_in_friend_cells_Shifted_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080902/0309-165128902991183-520240728-1-4myabx-libre.pdf?1722186002=\u0026response-content-disposition=attachment%3B+filename%3DNuclear_lipids_in_friend_cells_Shifted_p.pdf\u0026Expires=1739787211\u0026Signature=AzkGoGrnlrrYIVC-Jr7VJXplwDNWsaMnGKfVDixE7CJ-LFO5cd~YSs0jgp9ONz6O7IA5hjPT26JuQeSTjciJ0bhs3n8wiR~2z65f5MSM3vWz1C6IGEa5nAwy3q2M~KmqRKPTiEnjW7L41TJyiKDyPI7IevnRSjSGw7DDdl9Zkm9Tlr3Td6S28B-CnKtSfE73KVFcv~xThb93msMdxFWTxBFcHzst-NPAK1CyrCiKPnI81WNlXw5qR2ByWmUTrSJVXJ-XmxCgf1EDhF-AwQoIoOseXfZXCuLA5fYSu6Q7xdQ-mUolsvbD8C6kO1VnERdoVvmVlEALSo1g1oAabsUprw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413152"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413152/Phospholipids_as_components_of_the_nuclear_matrix_their_possible_biological_significance"><img alt="Research paper thumbnail of Phospholipids as components of the nuclear matrix: their possible biological significance" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413152/Phospholipids_as_components_of_the_nuclear_matrix_their_possible_biological_significance">Phospholipids as components of the nuclear matrix: their possible biological significance</a></div><div class="wp-workCard_item"><span>Basic and applied histochemistry</span><span>, 1987</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The phospholipid involvement in the regulation of the functional and structural properties of the...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The phospholipid involvement in the regulation of the functional and structural properties of the nuclear matrix is discussed analysing the results obtained with the enzymic removal of these molecules. Namely phospholipids seem to mediate hydrophobic interactions between nucleic acids and matrix fibrils either directly or indirectly through an association with the non-histone proteins of the matrix.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413152"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413152"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413152; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413152]").text(description); $(".js-view-count[data-work-id=122413152]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413152; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413152']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413152]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413152,"title":"Phospholipids as components of the nuclear matrix: their possible biological significance","internal_url":"https://www.academia.edu/122413152/Phospholipids_as_components_of_the_nuclear_matrix_their_possible_biological_significance","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413151"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413151/Phospholipase_C_%CE%B21_is_predominantely_expressed_in_the_granular_layer_of_rat_cerebellar_cortex"><img alt="Research paper thumbnail of Phospholipase-C β1 is predominantely expressed in the granular layer of rat cerebellar cortex" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413151/Phospholipase_C_%CE%B21_is_predominantely_expressed_in_the_granular_layer_of_rat_cerebellar_cortex">Phospholipase-C β1 is predominantely expressed in the granular layer of rat cerebellar cortex</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Medicine</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413151"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413151"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413151; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413151]").text(description); $(".js-view-count[data-work-id=122413151]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413151; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413151']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413151]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413151,"title":"Phospholipase-C β1 is predominantely expressed in the granular layer of rat cerebellar cortex","internal_url":"https://www.academia.edu/122413151/Phospholipase_C_%CE%B21_is_predominantely_expressed_in_the_granular_layer_of_rat_cerebellar_cortex","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413150"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413150/PLC%CE%B21a_and_PLC%CE%B21b_Selective_Regulation_and_Cyclin_D3_Modulation_Reduced_by_Kinamycin_F_During_K562_Cell_Differentiation"><img alt="Research paper thumbnail of PLCβ1a and PLCβ1b Selective Regulation and Cyclin D3 Modulation Reduced by Kinamycin F During K562 Cell Differentiation" class="work-thumbnail" src="https://attachments.academia-assets.com/117080903/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413150/PLC%CE%B21a_and_PLC%CE%B21b_Selective_Regulation_and_Cyclin_D3_Modulation_Reduced_by_Kinamycin_F_During_K562_Cell_Differentiation">PLCβ1a and PLCβ1b Selective Regulation and Cyclin D3 Modulation Reduced by Kinamycin F During K562 Cell Differentiation</a></div><div class="wp-workCard_item"><span>Journal of Cellular Physiology</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Here we report that both PLCβ1a and PLCβ1b are relevant regulators of erythropoiesis in that kina...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Here we report that both PLCβ1a and PLCβ1b are relevant regulators of erythropoiesis in that kinamycin F, a potent inducer of γ‐globin production in K562 cells, caused a selectively reduction of both PLCβ1 isozymes even though the results point out that the effect of the drug is mainly directed toward the expression of the PLCβ1a isoform. We have identified a different role for the two isozymes as regulators of K562 differentiation process induced by kinamycin F. The overexpression of PLCβ1b induced an increase in γ‐globin expression even in the absence of kinamycin F. Moreover during K562 differentiation, cyclin D3 level is regulated by PLCβ1 signaling pathway. Namely the amplification of the expression of the PLCβ1a, but not of PLCβ1b, is able to maintain high levels of expression of cyclin D3 even after treatment with kinamycin F. This could be due to their different distribution in the cell compartments since the amount of PLCβ1b is mainly present in the nucleus in respect to PL...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fe84e3de631c3296bf3798bb534cec2a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080903,"asset_id":122413150,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080903/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413150"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413150"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413150; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413150]").text(description); $(".js-view-count[data-work-id=122413150]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413150; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413150']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fe84e3de631c3296bf3798bb534cec2a" } } $('.js-work-strip[data-work-id=122413150]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413150,"title":"PLCβ1a and PLCβ1b Selective Regulation and Cyclin D3 Modulation Reduced by Kinamycin F During K562 Cell Differentiation","internal_url":"https://www.academia.edu/122413150/PLC%CE%B21a_and_PLC%CE%B21b_Selective_Regulation_and_Cyclin_D3_Modulation_Reduced_by_Kinamycin_F_During_K562_Cell_Differentiation","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080903,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080903/thumbnails/1.jpg","file_name":"jcp.2477620240728-1-at0kws.pdf","download_url":"https://www.academia.edu/attachments/117080903/download_file","bulk_download_file_name":"PLC1a_and_PLC1b_Selective_Regulation_a.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080903/jcp.2477620240728-1-at0kws-libre.pdf?1722186004=\u0026response-content-disposition=attachment%3B+filename%3DPLC1a_and_PLC1b_Selective_Regulation_a.pdf\u0026Expires=1739787211\u0026Signature=NP1S7zRSeij2glkx15UEZufRn~IEXOa2yB5NwlDf-aZ7ozMW3o~u16xYYPapugSt2OB8bazVxFw3U4aWN4FWflT~kqUnW-n4afhm8DrJITmLT2tx3mkigXLDyZnSgvK0E9fu09v23KMiCsxxIeImKVIylfoySu00BN40eLer0iS2TkXCVgGYngVVnLwXp6KJwK35LQJ-fUp7pm1ffaBK9roXI3izJSR7NZys~eudZhgJ15AZMG-G67sIGdY3NC0hYBf3a9uHfMR57BqHZz-YzaJuke5kkMiI87Kqp9JoocH1qMjuax6fdD2M4bMKxtnifq2DjjVv3i2AvtvSRmfy5Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413149"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413149/P060_Effect_of_azacitidine_on_PI_PLC_beta1_expression_and_Akt_activation_in_a_patient_affected_by_high_risk_myelodysplastic_syndrome_MDS_"><img alt="Research paper thumbnail of P060 Effect of azacitidine on PI-PLC-beta1 expression and Akt activation in a patient affected by high-risk myelodysplastic syndrome (MDS)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413149/P060_Effect_of_azacitidine_on_PI_PLC_beta1_expression_and_Akt_activation_in_a_patient_affected_by_high_risk_myelodysplastic_syndrome_MDS_">P060 Effect of azacitidine on PI-PLC-beta1 expression and Akt activation in a patient affected by high-risk myelodysplastic syndrome (MDS)</a></div><div class="wp-workCard_item"><span>Leukemia Research</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413149"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413149"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413149; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413149]").text(description); $(".js-view-count[data-work-id=122413149]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413149; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413149']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413149]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413149,"title":"P060 Effect of azacitidine on PI-PLC-beta1 expression and Akt activation in a patient affected by high-risk myelodysplastic syndrome (MDS)","internal_url":"https://www.academia.edu/122413149/P060_Effect_of_azacitidine_on_PI_PLC_beta1_expression_and_Akt_activation_in_a_patient_affected_by_high_risk_myelodysplastic_syndrome_MDS_","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413148"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413148/No_discrete_complexes_containing_DNA_polymerase_%CE%B1_activity_can_be_solubilized_from_the_heat_stabilized_nuclear_matrix_prepared_from_HeLa_S3_cells"><img alt="Research paper thumbnail of No discrete complexes containing DNA polymerase α activity can be solubilized from the heat-stabilized nuclear matrix prepared from HeLa S3 cells" class="work-thumbnail" src="https://attachments.academia-assets.com/117080901/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413148/No_discrete_complexes_containing_DNA_polymerase_%CE%B1_activity_can_be_solubilized_from_the_heat_stabilized_nuclear_matrix_prepared_from_HeLa_S3_cells">No discrete complexes containing DNA polymerase α activity can be solubilized from the heat-stabilized nuclear matrix prepared from HeLa S3 cells</a></div><div class="wp-workCard_item"><span>Cell Biochemistry and Function</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Most of the DNA polymerase a activity, bound to the heat-stabilized nuclear matrix prepared from ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Most of the DNA polymerase a activity, bound to the heat-stabilized nuclear matrix prepared from HeLa S3 cells, was released as a matrix extract by sonication. When the extract was centrifuged in a 5-20 per cent linear sucrose gradient no definite peaks of activity could be identified. Most of the activity sedimented to the bottom of the tube under all the conditions tested, whilst the remaining activity was associated with matrix fragments of various and irregular size. No 10 S complexes, containing polymerase activity, were seen after incubation of the extract for 16 h before centrifugation. Other solubilization procedures (i.e. treatment of the matrix with cheiating agents, high pH associated with reducing agents, ionic and nonionic detergents) failed to produce release of matrix-bound DNA polymerase a activity. In contrast, we released 10 S complexes, containing polymerase activity, from the matrix prepared from nuclei not exposed to heat. We conclude that a 37°C incubation of isolated nuclei before extraction with 2 M NaCl and DNase I digestion causes DNA polymerase a to bind to the nuclear matrix in a form that cannot subsequently be released as discrete components, at variance with previous results obtained with the matrix prepared from regenerating rat liver. KEY WORDS-Nuclear matrix; DNA polymerase a; soluble complexes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e82f46d8756ddb91be47c7fc756128d1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080901,"asset_id":122413148,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080901/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413148"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413148"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413148; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413148]").text(description); $(".js-view-count[data-work-id=122413148]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413148; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413148']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e82f46d8756ddb91be47c7fc756128d1" } } $('.js-work-strip[data-work-id=122413148]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413148,"title":"No discrete complexes containing DNA polymerase α activity can be solubilized from the heat-stabilized nuclear matrix prepared from HeLa S3 cells","internal_url":"https://www.academia.edu/122413148/No_discrete_complexes_containing_DNA_polymerase_%CE%B1_activity_can_be_solubilized_from_the_heat_stabilized_nuclear_matrix_prepared_from_HeLa_S3_cells","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080901,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080901/thumbnails/1.jpg","file_name":"cbf.29012010620240728-1-o397dk.pdf","download_url":"https://www.academia.edu/attachments/117080901/download_file","bulk_download_file_name":"No_discrete_complexes_containing_DNA_pol.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080901/cbf.29012010620240728-1-o397dk-libre.pdf?1722186004=\u0026response-content-disposition=attachment%3B+filename%3DNo_discrete_complexes_containing_DNA_pol.pdf\u0026Expires=1739787211\u0026Signature=HBycRKtykgvXVbaUA51KrVlBrB4sQSwivFHtZJJ7wQ7doYj9t4dlcBcM5RkpxvTVzdjEueit2flPX~jXoighxwfA0ysj3LLzuKbJI25nvtCCEmUKI9Ba8qo--b0JwG9G-We5ocCRa8uc0PnoXd7dyVTLEzVzTwuzIKYKs4RmzwgDOLmsIyZQGeb3jBHl9aU6EP0m671hc~~8mwv9ujmqc7mzikhO4LL25qEZEsX~z7sDiCumSL5rS1665UzLRqw8uPtb7qUbjZzpONtDe~kUBVXuAuhaOkom54CxDtlfcvVV2yV9qJ6ek6AIBFCkosGelXgdMI9ELkU0ZeAw1Joetg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413147"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413147/Temporal_changes_in_intracellular_distribution_of_protein_kinase_C_in_Swiss_3T3_cells_during_mitogenic_stimulation_with_insulin_like_growth_factor_I_and_bombesin_Translocation_to_the_nucleus_follows_rapid_changes_in_nuclear_polyphosphoinositides"><img alt="Research paper thumbnail of Temporal changes in intracellular distribution of protein kinase C in Swiss 3T3 cells during mitogenic stimulation with insulin-like growth factor I and bombesin: Translocation to the nucleus follows rapid changes in nuclear polyphosphoinositides" class="work-thumbnail" src="https://attachments.academia-assets.com/117080913/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413147/Temporal_changes_in_intracellular_distribution_of_protein_kinase_C_in_Swiss_3T3_cells_during_mitogenic_stimulation_with_insulin_like_growth_factor_I_and_bombesin_Translocation_to_the_nucleus_follows_rapid_changes_in_nuclear_polyphosphoinositides">Temporal changes in intracellular distribution of protein kinase C in Swiss 3T3 cells during mitogenic stimulation with insulin-like growth factor I and bombesin: Translocation to the nucleus follows rapid changes in nuclear polyphosphoinositides</a></div><div class="wp-workCard_item"><span>Biochemical and Biophysical Research Communications</span><span>, 1991</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f21cfaafbdbebb7f28872c3b335358c0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080913,"asset_id":122413147,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080913/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413147"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413147"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413147; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413147]").text(description); $(".js-view-count[data-work-id=122413147]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413147; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413147']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f21cfaafbdbebb7f28872c3b335358c0" } } $('.js-work-strip[data-work-id=122413147]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413147,"title":"Temporal changes in intracellular distribution of protein kinase C in Swiss 3T3 cells during mitogenic stimulation with insulin-like growth factor I and bombesin: Translocation to the nucleus follows rapid changes in nuclear polyphosphoinositides","internal_url":"https://www.academia.edu/122413147/Temporal_changes_in_intracellular_distribution_of_protein_kinase_C_in_Swiss_3T3_cells_during_mitogenic_stimulation_with_insulin_like_growth_factor_I_and_bombesin_Translocation_to_the_nucleus_follows_rapid_changes_in_nuclear_polyphosphoinositides","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080913,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080913/thumbnails/1.jpg","file_name":"0006-291x28912992009-920240728-1-9po9xj.pdf","download_url":"https://www.academia.edu/attachments/117080913/download_file","bulk_download_file_name":"Temporal_changes_in_intracellular_distri.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080913/0006-291x28912992009-920240728-1-9po9xj-libre.pdf?1722185999=\u0026response-content-disposition=attachment%3B+filename%3DTemporal_changes_in_intracellular_distri.pdf\u0026Expires=1739787211\u0026Signature=VQnk3toQ4Rb9~YBUSMt7wl6Sn5cQKzlQUkj-5yYQf0FcefvTNcYSLT2aiz3fJm7L931rtgtDIErFnQLnVJsZNdIhZNutYtUKvriACIU7uSLIafkI8LLfcqGRfr~OOtid-WhxCpTAp-vey4OeOdz~Dqh5~QYroOoiOxR6xp2hZv~xPvTTMhyVNNWZ8GdqD42nw5TMtBa9AZgIJI~q-0QNDTqiORwv7PoTUbBdU7RxW74h3QawHJurdJehAomJvX~h~8OTm64OmLzQVvMOF~aOjh9BLbDYEdaQWV9jKDWxsOgI12WqDnP9AVJmxLA0CubePA6UHpekyLBWa2n9o5Lf-Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413146"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/122413146/The_Protein_Kinase_Inhibitor_Staurosporine_Induces_Morphological_Changes_Typical_of_Apoptosis_in_MOLT_4_Cells_without_Concomitant_DNA_Fragmentation"><img alt="Research paper thumbnail of The Protein Kinase Inhibitor Staurosporine Induces Morphological Changes Typical of Apoptosis in MOLT-4 Cells without Concomitant DNA Fragmentation" class="work-thumbnail" src="https://attachments.academia-assets.com/117080900/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/122413146/The_Protein_Kinase_Inhibitor_Staurosporine_Induces_Morphological_Changes_Typical_of_Apoptosis_in_MOLT_4_Cells_without_Concomitant_DNA_Fragmentation">The Protein Kinase Inhibitor Staurosporine Induces Morphological Changes Typical of Apoptosis in MOLT-4 Cells without Concomitant DNA Fragmentation</a></div><div class="wp-workCard_item"><span>Biochemical and Biophysical Research Communications</span><span>, 1993</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4462b88c8971dd179e79bd215d58a21b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":117080900,"asset_id":122413146,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/117080900/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413146"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413146"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413146; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413146]").text(description); $(".js-view-count[data-work-id=122413146]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413146; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413146']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4462b88c8971dd179e79bd215d58a21b" } } $('.js-work-strip[data-work-id=122413146]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413146,"title":"The Protein Kinase Inhibitor Staurosporine Induces Morphological Changes Typical of Apoptosis in MOLT-4 Cells without Concomitant DNA Fragmentation","internal_url":"https://www.academia.edu/122413146/The_Protein_Kinase_Inhibitor_Staurosporine_Induces_Morphological_Changes_Typical_of_Apoptosis_in_MOLT_4_Cells_without_Concomitant_DNA_Fragmentation","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[{"id":117080900,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/117080900/thumbnails/1.jpg","file_name":"bbrc.1993.158420240728-1-vb5528.pdf","download_url":"https://www.academia.edu/attachments/117080900/download_file","bulk_download_file_name":"The_Protein_Kinase_Inhibitor_Staurospori.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/117080900/bbrc.1993.158420240728-1-vb5528-libre.pdf?1722185999=\u0026response-content-disposition=attachment%3B+filename%3DThe_Protein_Kinase_Inhibitor_Staurospori.pdf\u0026Expires=1739787211\u0026Signature=WVXlfnUtmqqI~CvSyIimX4VX6dKc0VfUXB6UThSQ4Op7kfSg34gnO5rt5wXOdBlQkA4vMp1RN3wUrDyRhx7cp6TNJVW3BDmkZeQhCDesbwJU9R71XNqeCa2Tv9WXUeEQyay-Na13mDc13x5AhaV2lu~LxgVh6wewCBQED8g2eodStT~RlvP896nSZey0T5Ntkmtuv9uT7XvAgg871OqJDsT5TmO3fAkms-TOxRsZwbRZvLjyG1MMAkYPlZwmbAItCqMLaVn0PqB4fyTEaj98t5tAmQBqPyiMEd~7sfiFVh39GDQ8pPlwlVUsdVnMt4RGQkO-Eh~nI~kPVjhXfGzc0A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="122413116"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/122413116/Inositide_specific_phospholipase_C_signalling_in_the_nucleus"><img alt="Research paper thumbnail of Inositide-specific phospholipase C signalling in the nucleus" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/122413116/Inositide_specific_phospholipase_C_signalling_in_the_nucleus">Inositide-specific phospholipase C signalling in the nucleus</a></div><div class="wp-workCard_item"><span>European Journal of Histochemistry</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The nucleus of eukaryotic cells contains all the information needed for cell proliferation and di...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The nucleus of eukaryotic cells contains all the information needed for cell proliferation and differentiation, however the initiation of these programmes are dependent on the signalling pathway elicited by different agonists. The existence of a nuclear phosphoinositide signalling stems from the early evidence that isolated nuclei posses the lipid kinases capable of phosphorylating phosphatidylinositol (PI) and phosphatidylinositol 4-phosphate (PIP). The synthesis of phosphatidylinositol 4,5- phosphate (PIP2) was clearly increased only in the nuclear fraction from Friend cells terminally differentiated towards erythrocytes (Cocco et al., 1987). On the contrary its amount along with that of PIP was decreased in nuclei of Swiss 3T3 cells stimulated to grow with insulin-like growth factor-I (IGFI) (Manzoli et al., 1989). Following these early observations we and others have demonstrated in several cell type the participation of the whole phosphoinositide cycle in the nucleus (Cocco et ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="122413116"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="122413116"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 122413116; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=122413116]").text(description); $(".js-view-count[data-work-id=122413116]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 122413116; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='122413116']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=122413116]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":122413116,"title":"Inositide-specific phospholipase C signalling in the nucleus","internal_url":"https://www.academia.edu/122413116/Inositide_specific_phospholipase_C_signalling_in_the_nucleus","owner_id":32694906,"coauthors_can_edit":true,"owner":{"id":32694906,"first_name":"Lucio","middle_initials":null,"last_name":"Cocco","page_name":"LCocco","domain_name":"aiccon","created_at":"2015-07-01T03:02:40.312-07:00","display_name":"Lucio Cocco","url":"https://aiccon.academia.edu/LCocco"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; } .sign-in-with-apple-button > div { margin: 0 auto; / This centers the Apple-rendered button horizontally }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "15c3e30b8a584ad50f5af626baf87241a68c96fd3dc964feaaba9f0828d3cf4a", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="Zuqr9F_RSXnccx86whmWGMK2eIwHeYpHZGbUS6RL_VtQohCOmdqqb59m89xf5yoLQP7BUg1fc1g3L1huHHj-1A" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://aiccon.academia.edu/LCocco" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="EeF7rIL1xFRxAJEClPpF4Ie7zZneKl21qxrM4XvoPPYnqcDWRP4nQjIVfeQJBPnzBfN0R9QMpKr4U0DEw9s_eQ" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2025</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>