CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>V. Kaltsatos - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="TtzU2DMvOKK443vySdrC/mt96ondy63ws/BfDB+oq57hEXXWXIoSbpWzBALwBkwmseGp+56bhBBn2Ceakwj77A==" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-77f7b87cb1583fc59aa8f94756ebfe913345937eb932042b4077563bebb5fb4b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-9e8218e1301001388038e3fc3427ed00d079a4760ff7745d1ec1b2d59103170a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-b2b823dd904da60a48fd1bfa1defd840610c2ff414d3f39ed3af46277ab8df3b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> <meta name="author" content="v. kaltsatos" /> <meta name="description" content="V. Kaltsatos: 5 Followers, 1 Following, 21 Research papers. Research interests: Cardiovascular research, Cardiothoracic Surgery, and Veterinary Cardiology." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = '9387f500ddcbb8d05c67bef28a2fe0334f1aafb8'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":15268,"monthly_visitors":"113 million","monthly_visitor_count":113692424,"monthly_visitor_count_in_millions":113,"user_count":277715988,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1733020447000); window.Aedu.timeDifference = new Date().getTime() - 1733020447000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-bdb9e8c097f01e611f2fc5e2f1a9dc599beede975e2ae5629983543a1726e947.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-3e572e3b706c3ed2ec5b2c1cb44a411fadc81f62a97963cb7bd9c327a0a9d5f2.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-2e8d3f30eaaddd1debd6ce4630b3453b23a23c91ac7c823ddf8822879835b029.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://independent.academia.edu/VKaltsatos" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://medium.com/@academia">Blog</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-ae3d0ee232cd83d11499343688b0160a3c7db15e95cb2d0844cae78d49ea53f1.js" defer="defer"></script><script>Aedu.rankings = { showPaperRankingsLink: false } $viewedUser = Aedu.User.set_viewed( {"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos","photo":"/images/s65_no_pic.png","has_photo":false,"is_analytics_public":false,"interests":[{"id":92910,"name":"Cardiovascular research","url":"https://www.academia.edu/Documents/in/Cardiovascular_research"},{"id":649,"name":"Cardiothoracic Surgery","url":"https://www.academia.edu/Documents/in/Cardiothoracic_Surgery"},{"id":42084,"name":"Veterinary Cardiology","url":"https://www.academia.edu/Documents/in/Veterinary_Cardiology"},{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/VKaltsatos","location":"/VKaltsatos","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/VKaltsatos","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-f1fd34a9-3737-419a-acb2-5e2ee52f1c90"></div> <div id="ProfileCheckPaperUpdate-react-component-f1fd34a9-3737-419a-acb2-5e2ee52f1c90"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">V. Kaltsatos</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="V." data-follow-user-id="36529724" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="36529724"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">5</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">1</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-author</p><p class="data">1</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="36529724" href="https://www.academia.edu/Documents/in/Cardiovascular_research"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/VKaltsatos","location":"/VKaltsatos","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/VKaltsatos","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Cardiovascular research"]}" data-trace="false" data-dom-id="Pill-react-component-879990f4-371a-4efb-8f50-7cf72b7707f7"></div> <div id="Pill-react-component-879990f4-371a-4efb-8f50-7cf72b7707f7"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="36529724" href="https://www.academia.edu/Documents/in/Cardiothoracic_Surgery"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Cardiothoracic Surgery"]}" data-trace="false" data-dom-id="Pill-react-component-d041ddce-d870-4d08-8f15-a02455245afb"></div> <div id="Pill-react-component-d041ddce-d870-4d08-8f15-a02455245afb"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="36529724" href="https://www.academia.edu/Documents/in/Veterinary_Cardiology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Veterinary Cardiology"]}" data-trace="false" data-dom-id="Pill-react-component-23442387-3ccd-49e0-8e23-d63de8748759"></div> <div id="Pill-react-component-23442387-3ccd-49e0-8e23-d63de8748759"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="36529724" href="https://www.academia.edu/Documents/in/Surgery"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Surgery"]}" data-trace="false" data-dom-id="Pill-react-component-d663bd06-28c3-4001-b670-dfa14ebd5e47"></div> <div id="Pill-react-component-d663bd06-28c3-4001-b670-dfa14ebd5e47"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by V. Kaltsatos</h3></div><div class="js-work-strip profile--work_container" data-work-id="113553300"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113553300/Six_month_target_animal_safety_study_of_spironolactone_and_benazepril_hydrochloride_combination_Cardalis_R_for_oral_administration_in_dogs"><img alt="Research paper thumbnail of Six month target animal safety study of spironolactone and benazepril hydrochloride combination (Cardalis (R)) for oral administration in dogs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113553300/Six_month_target_animal_safety_study_of_spironolactone_and_benazepril_hydrochloride_combination_Cardalis_R_for_oral_administration_in_dogs">Six month target animal safety study of spironolactone and benazepril hydrochloride combination (Cardalis (R)) for oral administration in dogs</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113553300"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113553300"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113553300; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113553300]").text(description); $(".js-view-count[data-work-id=113553300]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113553300; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113553300']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113553300, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=113553300]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113553300,"title":"Six month target animal safety study of spironolactone and benazepril hydrochloride combination (Cardalis (R)) for oral administration in dogs","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2012,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/113553300/Six_month_target_animal_safety_study_of_spironolactone_and_benazepril_hydrochloride_combination_Cardalis_R_for_oral_administration_in_dogs","translated_internal_url":"","created_at":"2024-01-15T14:44:24.751-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Six_month_target_animal_safety_study_of_spironolactone_and_benazepril_hydrochloride_combination_Cardalis_R_for_oral_administration_in_dogs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":3329465,"name":"Spironolactone","url":"https://www.academia.edu/Documents/in/Spironolactone"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103418510"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103418510/Rationale_of_a_Combination_of_Spironolactone_and_Benazepril_for_Treatment_of_Heart_Failure_in_Dog"><img alt="Research paper thumbnail of Rationale of a Combination of Spironolactone and Benazepril for Treatment of Heart Failure in Dog" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103418510/Rationale_of_a_Combination_of_Spironolactone_and_Benazepril_for_Treatment_of_Heart_Failure_in_Dog">Rationale of a Combination of Spironolactone and Benazepril for Treatment of Heart Failure in Dog</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103418510"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103418510"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103418510; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103418510]").text(description); $(".js-view-count[data-work-id=103418510]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103418510; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103418510']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 103418510, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=103418510]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103418510,"title":"Rationale of a Combination of Spironolactone and Benazepril for Treatment of Heart Failure in Dog","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2012,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/103418510/Rationale_of_a_Combination_of_Spironolactone_and_Benazepril_for_Treatment_of_Heart_Failure_in_Dog","translated_internal_url":"","created_at":"2023-06-16T00:00:27.132-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Rationale_of_a_Combination_of_Spironolactone_and_Benazepril_for_Treatment_of_Heart_Failure_in_Dog","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure"},{"id":3329465,"name":"Spironolactone","url":"https://www.academia.edu/Documents/in/Spironolactone"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="99906279"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/99906279/Bovine_mastitis_and_intramammary_drug_delivery_review_and_perspectives"><img alt="Research paper thumbnail of Bovine mastitis and intramammary drug delivery: review and perspectives" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/99906279/Bovine_mastitis_and_intramammary_drug_delivery_review_and_perspectives">Bovine mastitis and intramammary drug delivery: review and perspectives</a></div><div class="wp-workCard_item"><span>Advanced Drug Delivery Reviews</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Intramammary infections (IMIs) represent a major feature in bovine pathology. The treatment of IM...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Intramammary infections (IMIs) represent a major feature in bovine pathology. The treatment of IMIs concern antimicrobial substances. Therapeutic strategies involve administration of immediate release formulations during lactation with or without long-acting formulations during the dry period. Current treatments are not very successful and cure rates are poor, especially towards Staphylococcus aureus which is responsible for chronic infections and huge economic losses. New strategies have recently been investigated. These include particular immunomodulators like lysostaphin or cytokines, and novel formulations (e.g. liposomes, microparticles or nanoparticles) that allow uptake of the active component by phagocytes and thus prolong an enhanced antibacterial activity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="99906279"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="99906279"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 99906279; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=99906279]").text(description); $(".js-view-count[data-work-id=99906279]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 99906279; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='99906279']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 99906279, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=99906279]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":99906279,"title":"Bovine mastitis and intramammary drug delivery: review and perspectives","translated_title":"","metadata":{"abstract":"Intramammary infections (IMIs) represent a major feature in bovine pathology. The treatment of IMIs concern antimicrobial substances. Therapeutic strategies involve administration of immediate release formulations during lactation with or without long-acting formulations during the dry period. Current treatments are not very successful and cure rates are poor, especially towards Staphylococcus aureus which is responsible for chronic infections and huge economic losses. New strategies have recently been investigated. These include particular immunomodulators like lysostaphin or cytokines, and novel formulations (e.g. liposomes, microparticles or nanoparticles) that allow uptake of the active component by phagocytes and thus prolong an enhanced antibacterial activity.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Advanced Drug Delivery Reviews"},"translated_abstract":"Intramammary infections (IMIs) represent a major feature in bovine pathology. The treatment of IMIs concern antimicrobial substances. Therapeutic strategies involve administration of immediate release formulations during lactation with or without long-acting formulations during the dry period. Current treatments are not very successful and cure rates are poor, especially towards Staphylococcus aureus which is responsible for chronic infections and huge economic losses. New strategies have recently been investigated. These include particular immunomodulators like lysostaphin or cytokines, and novel formulations (e.g. liposomes, microparticles or nanoparticles) that allow uptake of the active component by phagocytes and thus prolong an enhanced antibacterial activity.","internal_url":"https://www.academia.edu/99906279/Bovine_mastitis_and_intramammary_drug_delivery_review_and_perspectives","translated_internal_url":"","created_at":"2023-04-09T02:44:19.063-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Bovine_mastitis_and_intramammary_drug_delivery_review_and_perspectives","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery"},{"id":17008,"name":"Mastitis","url":"https://www.academia.edu/Documents/in/Mastitis"},{"id":17014,"name":"Bovine Mastitis","url":"https://www.academia.edu/Documents/in/Bovine_Mastitis"},{"id":19826,"name":"Lactation","url":"https://www.academia.edu/Documents/in/Lactation"},{"id":23390,"name":"Pharmaceutical Chemistry","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":41747,"name":"Dosage Form","url":"https://www.academia.edu/Documents/in/Dosage_Form"},{"id":64660,"name":"Controlled release","url":"https://www.academia.edu/Documents/in/Controlled_release"},{"id":95522,"name":"Advanced Drug Delivery Research","url":"https://www.academia.edu/Documents/in/Advanced_Drug_Delivery_Research"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems"},{"id":183266,"name":"Liposome","url":"https://www.academia.edu/Documents/in/Liposome"},{"id":220036,"name":"Antimicrobial","url":"https://www.academia.edu/Documents/in/Antimicrobial"},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle"},{"id":290432,"name":"Antibacterial activity","url":"https://www.academia.edu/Documents/in/Antibacterial_activity"},{"id":605367,"name":"Economic Loss","url":"https://www.academia.edu/Documents/in/Economic_Loss"},{"id":2670783,"name":"Chronic Infection","url":"https://www.academia.edu/Documents/in/Chronic_Infection"},{"id":3779594,"name":"dry period","url":"https://www.academia.edu/Documents/in/dry_period"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"},{"id":4042244,"name":"Lysostaphin","url":"https://www.academia.edu/Documents/in/Lysostaphin"}],"urls":[{"id":30482495,"url":"https://api.elsevier.com/content/article/PII:S0169409X01001600?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90609143"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90609143/Clinical_evaluation_of_bioadhesive_ophthalmic_drug_inserts_BODI_for_the_treatment_of_external_ocular_infections_in_dogs"><img alt="Research paper thumbnail of Clinical evaluation of bioadhesive ophthalmic drug inserts (BODI®) for the treatment of external ocular infections in dogs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90609143/Clinical_evaluation_of_bioadhesive_ophthalmic_drug_inserts_BODI_for_the_treatment_of_external_ocular_infections_in_dogs">Clinical evaluation of bioadhesive ophthalmic drug inserts (BODI®) for the treatment of external ocular infections in dogs</a></div><div class="wp-workCard_item"><span>Journal of Controlled Release</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the case of external ocular diseases such as conjunctivitis, keratoconjunctivitis sicca (KCS) ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the case of external ocular diseases such as conjunctivitis, keratoconjunctivitis sicca (KCS) and superficial corneal ulcers, topical administration of eyedrops containing an antibacterial agent is often prescribed. Numerous daily instillations of eyedrops over several days are required for successful treatment, often leading to bad compliance. In addition, the reflex lachrymation following instillation promotes rapid elimination of the drug from the corneal surface. To overcome the disadvantage of repeated instillations, a soluble bioadhesive ophthalmic drug insert (BODI) to be placed in the lower cul de sac of the eye was developed. The clinical efficacy, after deposition of one insert and a classical eyedrop treatment (Tiacil), Virbac Laboratories), was investigated in dogs presenting conjunctivitis, superficial corneal ulcer or keratoconjunctivitis sicca (KCS). Similar total clinical recovery results were obtained after 3 and 7 days for both treatments. BODI can therefore advantageously be prescribed for the treatment of external ophthalmic diseases, by reducing the treatment to a single application and therefore improving compliance compared to classical eyedrop treatment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90609143"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90609143"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90609143; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90609143]").text(description); $(".js-view-count[data-work-id=90609143]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90609143; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90609143']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90609143, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90609143]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90609143,"title":"Clinical evaluation of bioadhesive ophthalmic drug inserts (BODI®) for the treatment of external ocular infections in dogs","translated_title":"","metadata":{"abstract":"In the case of external ocular diseases such as conjunctivitis, keratoconjunctivitis sicca (KCS) and superficial corneal ulcers, topical administration of eyedrops containing an antibacterial agent is often prescribed. Numerous daily instillations of eyedrops over several days are required for successful treatment, often leading to bad compliance. In addition, the reflex lachrymation following instillation promotes rapid elimination of the drug from the corneal surface. To overcome the disadvantage of repeated instillations, a soluble bioadhesive ophthalmic drug insert (BODI) to be placed in the lower cul de sac of the eye was developed. The clinical efficacy, after deposition of one insert and a classical eyedrop treatment (Tiacil), Virbac Laboratories), was investigated in dogs presenting conjunctivitis, superficial corneal ulcer or keratoconjunctivitis sicca (KCS). Similar total clinical recovery results were obtained after 3 and 7 days for both treatments. BODI can therefore advantageously be prescribed for the treatment of external ophthalmic diseases, by reducing the treatment to a single application and therefore improving compliance compared to classical eyedrop treatment.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Journal of Controlled Release"},"translated_abstract":"In the case of external ocular diseases such as conjunctivitis, keratoconjunctivitis sicca (KCS) and superficial corneal ulcers, topical administration of eyedrops containing an antibacterial agent is often prescribed. Numerous daily instillations of eyedrops over several days are required for successful treatment, often leading to bad compliance. In addition, the reflex lachrymation following instillation promotes rapid elimination of the drug from the corneal surface. To overcome the disadvantage of repeated instillations, a soluble bioadhesive ophthalmic drug insert (BODI) to be placed in the lower cul de sac of the eye was developed. The clinical efficacy, after deposition of one insert and a classical eyedrop treatment (Tiacil), Virbac Laboratories), was investigated in dogs presenting conjunctivitis, superficial corneal ulcer or keratoconjunctivitis sicca (KCS). Similar total clinical recovery results were obtained after 3 and 7 days for both treatments. BODI can therefore advantageously be prescribed for the treatment of external ophthalmic diseases, by reducing the treatment to a single application and therefore improving compliance compared to classical eyedrop treatment.","internal_url":"https://www.academia.edu/90609143/Clinical_evaluation_of_bioadhesive_ophthalmic_drug_inserts_BODI_for_the_treatment_of_external_ocular_infections_in_dogs","translated_internal_url":"","created_at":"2022-11-12T11:15:26.521-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Clinical_evaluation_of_bioadhesive_ophthalmic_drug_inserts_BODI_for_the_treatment_of_external_ocular_infections_in_dogs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery"},{"id":17721,"name":"Cornea","url":"https://www.academia.edu/Documents/in/Cornea"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":64660,"name":"Controlled release","url":"https://www.academia.edu/Documents/in/Controlled_release"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems"},{"id":245634,"name":"Eye","url":"https://www.academia.edu/Documents/in/Eye"},{"id":687524,"name":"Adhesives","url":"https://www.academia.edu/Documents/in/Adhesives"},{"id":702103,"name":"Antibacterial Agent","url":"https://www.academia.edu/Documents/in/Antibacterial_Agent"},{"id":1137112,"name":"Ophthalmic Solutions","url":"https://www.academia.edu/Documents/in/Ophthalmic_Solutions"},{"id":1174994,"name":"Bacterial Infection","url":"https://www.academia.edu/Documents/in/Bacterial_Infection"},{"id":1666741,"name":"Clinical evaluation","url":"https://www.academia.edu/Documents/in/Clinical_evaluation"},{"id":2793624,"name":"keratoconjunctivitis sicca","url":"https://www.academia.edu/Documents/in/keratoconjunctivitis_sicca"},{"id":3505901,"name":"vernal keratoconjunctivitis","url":"https://www.academia.edu/Documents/in/vernal_keratoconjunctivitis"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":25877818,"url":"https://api.elsevier.com/content/article/PII:S0168-3659(02)00284-5?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90609111"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90609111/Keeping_the_drug_in_your_eye"><img alt="Research paper thumbnail of Keeping the drug in your eye" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90609111/Keeping_the_drug_in_your_eye">Keeping the drug in your eye</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90609111"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90609111"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90609111; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90609111]").text(description); $(".js-view-count[data-work-id=90609111]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90609111; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90609111']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90609111, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90609111]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90609111,"title":"Keeping the drug in your eye","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1995,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/90609111/Keeping_the_drug_in_your_eye","translated_internal_url":"","created_at":"2022-11-12T11:15:00.475-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Keeping_the_drug_in_your_eye","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":42135,"name":"Drug","url":"https://www.academia.edu/Documents/in/Drug"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069671"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069671/Bioequivalence_study_of_two_long_acting_formulations_of_oxytetracycline_following_intramuscular_administration_in_the_sheep"><img alt="Research paper thumbnail of Bioequivalence study of two long-acting formulations of oxytetracycline following intramuscular administration in the sheep" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069671/Bioequivalence_study_of_two_long_acting_formulations_of_oxytetracycline_following_intramuscular_administration_in_the_sheep">Bioequivalence study of two long-acting formulations of oxytetracycline following intramuscular administration in the sheep</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069671"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069671"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069671; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069671]").text(description); $(".js-view-count[data-work-id=66069671]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069671; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069671']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069671, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069671]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069671,"title":"Bioequivalence study of two long-acting formulations of oxytetracycline following intramuscular administration in the sheep","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2000,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/66069671/Bioequivalence_study_of_two_long_acting_formulations_of_oxytetracycline_following_intramuscular_administration_in_the_sheep","translated_internal_url":"","created_at":"2021-12-26T23:44:33.413-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Bioequivalence_study_of_two_long_acting_formulations_of_oxytetracycline_following_intramuscular_administration_in_the_sheep","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069670"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069670/Specifications_for_the_design_of_dosage_forms_Report_of_an_SFSTP_commission"><img alt="Research paper thumbnail of Specifications for the design of dosage forms : Report of an SFSTP commission" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069670/Specifications_for_the_design_of_dosage_forms_Report_of_an_SFSTP_commission">Specifications for the design of dosage forms : Report of an SFSTP commission</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The need to elaborate specifications for the development of new dosage forms appears as a prerequ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The need to elaborate specifications for the development of new dosage forms appears as a prerequisite to quality control. This document must be presented as a contract between the different persons involved in the project and be capable of evolving during the different development phases. It must enable the formulation scientist to clearly define the objectives and key points of the new dosage form development. Early data necessary to elaborate these specifications are of scientific, economic, commercial, industrial, regulatory and environmental natures. Dans le cadre du developpement d&#39;une nouvelle forme pharmaceutique, l&#39;elaboration d&#39;un cahier des charges galenique apparait comme une necessite dans la maitrise de la qualite. Ce document doit etre contractuel, refletant les points de vue des differents acteurs du developpement, et evolutif en s&#39;adaptant aux differentes phases de mise au point. Il doit permettre aux galenistes de mieux definir les objectifs et les ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069670"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069670"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069670; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069670]").text(description); $(".js-view-count[data-work-id=66069670]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069670; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069670']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069670, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069670]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069670,"title":"Specifications for the design of dosage forms : Report of an SFSTP commission","translated_title":"","metadata":{"abstract":"The need to elaborate specifications for the development of new dosage forms appears as a prerequisite to quality control. This document must be presented as a contract between the different persons involved in the project and be capable of evolving during the different development phases. It must enable the formulation scientist to clearly define the objectives and key points of the new dosage form development. Early data necessary to elaborate these specifications are of scientific, economic, commercial, industrial, regulatory and environmental natures. Dans le cadre du developpement d\u0026#39;une nouvelle forme pharmaceutique, l\u0026#39;elaboration d\u0026#39;un cahier des charges galenique apparait comme une necessite dans la maitrise de la qualite. Ce document doit etre contractuel, refletant les points de vue des differents acteurs du developpement, et evolutif en s\u0026#39;adaptant aux differentes phases de mise au point. Il doit permettre aux galenistes de mieux definir les objectifs et les ...","publication_date":{"day":null,"month":null,"year":1996,"errors":{}}},"translated_abstract":"The need to elaborate specifications for the development of new dosage forms appears as a prerequisite to quality control. This document must be presented as a contract between the different persons involved in the project and be capable of evolving during the different development phases. It must enable the formulation scientist to clearly define the objectives and key points of the new dosage form development. Early data necessary to elaborate these specifications are of scientific, economic, commercial, industrial, regulatory and environmental natures. Dans le cadre du developpement d\u0026#39;une nouvelle forme pharmaceutique, l\u0026#39;elaboration d\u0026#39;un cahier des charges galenique apparait comme une necessite dans la maitrise de la qualite. Ce document doit etre contractuel, refletant les points de vue des differents acteurs du developpement, et evolutif en s\u0026#39;adaptant aux differentes phases de mise au point. Il doit permettre aux galenistes de mieux definir les objectifs et les ...","internal_url":"https://www.academia.edu/66069670/Specifications_for_the_design_of_dosage_forms_Report_of_an_SFSTP_commission","translated_internal_url":"","created_at":"2021-12-26T23:44:33.311-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Specifications_for_the_design_of_dosage_forms_Report_of_an_SFSTP_commission","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069669"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069669/Cahier_des_charges_en_conception_gal%C3%A9nique_Rapport_dune_commission_SFSTP"><img alt="Research paper thumbnail of Cahier des charges en conception galénique. Rapport d'une commission SFSTP" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069669/Cahier_des_charges_en_conception_gal%C3%A9nique_Rapport_dune_commission_SFSTP">Cahier des charges en conception galénique. Rapport d'une commission SFSTP</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dans le cadre du developpement d&#39;une nouvelle forme pharmaceutique, l&#39;elaboration d&#39;u...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dans le cadre du developpement d&#39;une nouvelle forme pharmaceutique, l&#39;elaboration d&#39;un cahier des charges galenique apparait comme une necessite dans la maitrise de la qualite. Ce document doit etre contractuel, refletant les points de vue des differents acteurs du developpement, et evolutif, en s&#39;adaptant aux differentes phases de mise au point. Il doit permettre aux galenistes de mieux definir les objectifs et les points clefs du developpement de la nouvelle forme pharmaceutique. Les donnees d&#39;entree pour l&#39;etablissement de ce cahier des charges doivent etre scientifiques, economiques, commerciales, industrielles, technico-reglementaires et environnementales. The need to elaborate specifications for the development of new dosage forms appears as a prerequisite to quality control. This document must be presented as a contract between the different persons involved in the project and be capable of evolving during the different development phases. It must enab...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069669"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069669"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069669; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069669]").text(description); $(".js-view-count[data-work-id=66069669]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069669; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069669']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069669, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069669]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069669,"title":"Cahier des charges en conception galénique. Rapport d'une commission SFSTP","translated_title":"","metadata":{"abstract":"Dans le cadre du developpement d\u0026#39;une nouvelle forme pharmaceutique, l\u0026#39;elaboration d\u0026#39;un cahier des charges galenique apparait comme une necessite dans la maitrise de la qualite. Ce document doit etre contractuel, refletant les points de vue des differents acteurs du developpement, et evolutif, en s\u0026#39;adaptant aux differentes phases de mise au point. Il doit permettre aux galenistes de mieux definir les objectifs et les points clefs du developpement de la nouvelle forme pharmaceutique. Les donnees d\u0026#39;entree pour l\u0026#39;etablissement de ce cahier des charges doivent etre scientifiques, economiques, commerciales, industrielles, technico-reglementaires et environnementales. The need to elaborate specifications for the development of new dosage forms appears as a prerequisite to quality control. This document must be presented as a contract between the different persons involved in the project and be capable of evolving during the different development phases. It must enab...","publication_date":{"day":null,"month":null,"year":1996,"errors":{}}},"translated_abstract":"Dans le cadre du developpement d\u0026#39;une nouvelle forme pharmaceutique, l\u0026#39;elaboration d\u0026#39;un cahier des charges galenique apparait comme une necessite dans la maitrise de la qualite. Ce document doit etre contractuel, refletant les points de vue des differents acteurs du developpement, et evolutif, en s\u0026#39;adaptant aux differentes phases de mise au point. Il doit permettre aux galenistes de mieux definir les objectifs et les points clefs du developpement de la nouvelle forme pharmaceutique. Les donnees d\u0026#39;entree pour l\u0026#39;etablissement de ce cahier des charges doivent etre scientifiques, economiques, commerciales, industrielles, technico-reglementaires et environnementales. The need to elaborate specifications for the development of new dosage forms appears as a prerequisite to quality control. This document must be presented as a contract between the different persons involved in the project and be capable of evolving during the different development phases. It must enab...","internal_url":"https://www.academia.edu/66069669/Cahier_des_charges_en_conception_gal%C3%A9nique_Rapport_dune_commission_SFSTP","translated_internal_url":"","created_at":"2021-12-26T23:44:33.189-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Cahier_des_charges_en_conception_galénique_Rapport_dune_commission_SFSTP","translated_slug":"","page_count":null,"language":"fr","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069668"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069668/The_efficacy_of_an_oral_treatment_with_paromomycin_against_an_experimental_infection_with_Giardia_in_calves"><img alt="Research paper thumbnail of The efficacy of an oral treatment with paromomycin against an experimental infection with Giardia in calves" class="work-thumbnail" src="https://attachments.academia-assets.com/77406319/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069668/The_efficacy_of_an_oral_treatment_with_paromomycin_against_an_experimental_infection_with_Giardia_in_calves">The efficacy of an oral treatment with paromomycin against an experimental infection with Giardia in calves</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7bd60b3bf450890db5fbf73b0fafed76" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77406319,"asset_id":66069668,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77406319/download_file?st=MTczMzAyMDQ0Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069668"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069668"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069668; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069668]").text(description); $(".js-view-count[data-work-id=66069668]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069668; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069668']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069668, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7bd60b3bf450890db5fbf73b0fafed76" } } $('.js-work-strip[data-work-id=66069668]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069668,"title":"The efficacy of an oral treatment with paromomycin against an experimental infection with Giardia in calves","translated_title":"","metadata":{"ai_title_tag":"Paromomycin Treatment Efficacy Against Giardia in Calves","grobid_abstract":"A controlled and blinded study was conducted to evaluate the efficacy and safety of a treatment with paromomycin sulphate against an experimental Giardia infection in calves. Animals were infected with 10 5 Giardia cysts of cattle origin and were either treated 11 days later with 25, 50 or 75 mg paromomycin/(kg body weight per day) during 5 consecutive days or not treated (control group). Efficacy was evaluated based on reduction in cyst excretion. Furthermore weight gain and diarrhea scores were monitored. In the group treated with 75 mg/kg per day there was a 100% reduction in cyst excretion until 9 days after the start of the treatment (D9) and a very high reduction (!98%) until D13. There was a high reduction (!93%) until D9 and D13 in the groups treated with 25 and 50 mg/kg, respectively. The cumulative cyst excretion on D13 was significantly (P \u003c 0.05) lower in the groups treated with 75 and 50 mg/kg compared to the control group. Although there was a trend towards higher weight gain and less diarrhea in the treated groups, differences between groups were not significant. No adverse reactions to the paromomycin treatment were recorded. Furthermore, the need for reliable parameters for evaluation of treatments against protozoal infections is emphasised.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"grobid_abstract_attachment_id":77406319},"translated_abstract":null,"internal_url":"https://www.academia.edu/66069668/The_efficacy_of_an_oral_treatment_with_paromomycin_against_an_experimental_infection_with_Giardia_in_calves","translated_internal_url":"","created_at":"2021-12-26T23:44:33.065-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":77406319,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406319/thumbnails/1.jpg","file_name":"j.vetpar.2005.09.00620211226-1060-spgyha.pdf","download_url":"https://www.academia.edu/attachments/77406319/download_file?st=MTczMzAyMDQ0Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_efficacy_of_an_oral_treatment_with_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406319/j.vetpar.2005.09.00620211226-1060-spgyha-libre.pdf?1640595262=\u0026response-content-disposition=attachment%3B+filename%3DThe_efficacy_of_an_oral_treatment_with_p.pdf\u0026Expires=1733024046\u0026Signature=NCNasItdq41LtGN8-7A65pXwIaj~2XddDfJ1dhtBL9IPdqas6gewJnTA-QCR60kEVrSKdTt0QqYU0faawbWXMK9vaOeNK1TqruBUApBjBBwK4Cjg7DnP~cjQCUA030fAII7PE42-Qdu9h8NbuGY8QsnYABZIEvcM4JIeK-~kOt4YwyqDcqAvYCC1R51U6-V03KA~khv5WOnN6pocwI~u7DWpgDqWxJ-xmkpN8I~xF12L1MtZGvMp8ahT0HUXPucSP1zdwmkyBIVlkoAW0YsCKRLnsfEUpPiQVYjWoBoCKsoROm7SU6X6lU17E1JS~2QeqV8ti6PVrCXtIBwZGugsow__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_efficacy_of_an_oral_treatment_with_paromomycin_against_an_experimental_infection_with_Giardia_in_calves","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[{"id":77406319,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406319/thumbnails/1.jpg","file_name":"j.vetpar.2005.09.00620211226-1060-spgyha.pdf","download_url":"https://www.academia.edu/attachments/77406319/download_file?st=MTczMzAyMDQ0Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_efficacy_of_an_oral_treatment_with_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406319/j.vetpar.2005.09.00620211226-1060-spgyha-libre.pdf?1640595262=\u0026response-content-disposition=attachment%3B+filename%3DThe_efficacy_of_an_oral_treatment_with_p.pdf\u0026Expires=1733024046\u0026Signature=NCNasItdq41LtGN8-7A65pXwIaj~2XddDfJ1dhtBL9IPdqas6gewJnTA-QCR60kEVrSKdTt0QqYU0faawbWXMK9vaOeNK1TqruBUApBjBBwK4Cjg7DnP~cjQCUA030fAII7PE42-Qdu9h8NbuGY8QsnYABZIEvcM4JIeK-~kOt4YwyqDcqAvYCC1R51U6-V03KA~khv5WOnN6pocwI~u7DWpgDqWxJ-xmkpN8I~xF12L1MtZGvMp8ahT0HUXPucSP1zdwmkyBIVlkoAW0YsCKRLnsfEUpPiQVYjWoBoCKsoROm7SU6X6lU17E1JS~2QeqV8ti6PVrCXtIBwZGugsow__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":44259,"name":"Diarrhea","url":"https://www.academia.edu/Documents/in/Diarrhea"},{"id":50634,"name":"Veterinary Parasitology","url":"https://www.academia.edu/Documents/in/Veterinary_Parasitology"},{"id":170652,"name":"Fisheries Sciences","url":"https://www.academia.edu/Documents/in/Fisheries_Sciences"},{"id":218462,"name":"Giardiasis","url":"https://www.academia.edu/Documents/in/Giardiasis"},{"id":238630,"name":"Experimental Infection","url":"https://www.academia.edu/Documents/in/Experimental_Infection"},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle"},{"id":469102,"name":"Feces","url":"https://www.academia.edu/Documents/in/Feces"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight"},{"id":1476273,"name":"Giardia","url":"https://www.academia.edu/Documents/in/Giardia"},{"id":1631043,"name":"Control Group","url":"https://www.academia.edu/Documents/in/Control_Group"},{"id":1993786,"name":"Cumulant","url":"https://www.academia.edu/Documents/in/Cumulant"},{"id":2463495,"name":"Random Allocation","url":"https://www.academia.edu/Documents/in/Random_Allocation"},{"id":3049943,"name":"treatment efficacy","url":"https://www.academia.edu/Documents/in/treatment_efficacy"},{"id":3562462,"name":"cattle diseases","url":"https://www.academia.edu/Documents/in/cattle_diseases"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069667"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069667/Efficacy_of_permethrin_dinotefuran_and_pyriproxyfen_on_adult_fleas_flea_eggs_collection_and_flea_egg_development_following_transplantation_of_mature_female_fleas_Ctenocephalides_felis_felis_from_cats_to_dogs"><img alt="Research paper thumbnail of Efficacy of permethrin, dinotefuran and pyriproxyfen on adult fleas, flea eggs collection, and flea egg development following transplantation of mature female fleas (Ctenocephalides felis felis) from cats to dogs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069667/Efficacy_of_permethrin_dinotefuran_and_pyriproxyfen_on_adult_fleas_flea_eggs_collection_and_flea_egg_development_following_transplantation_of_mature_female_fleas_Ctenocephalides_felis_felis_from_cats_to_dogs">Efficacy of permethrin, dinotefuran and pyriproxyfen on adult fleas, flea eggs collection, and flea egg development following transplantation of mature female fleas (Ctenocephalides felis felis) from cats to dogs</a></div><div class="wp-workCard_item"><span>Veterinary Parasitology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A novel spot-on formulation combining permethrin, pyriproxifen and dinotefuran (Vectra 3D™ spot-o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A novel spot-on formulation combining permethrin, pyriproxifen and dinotefuran (Vectra 3D™ spot-on solution for dogs) was evaluated in adult Beagle dogs in a study to determine adulticidal efficacy, egg laying inhibition and viability of Ctenocephalides felis felis eggs (development and emergence of fleas from the collected eggs). Prior to treatment sixteen dogs were checked for their ability to keep fleas 24 hours after infestation and were allocated to treatment groups: 8 dogs served as untreated controls, and 8 dogs were treated once with the tested formulation. The spot on was administered respecting the laboratory recommendations at a dosage of 65-126 mg/kg of permethrin; 8.9-17.4 mg/kg of dinotefuran and 0.8-1.5mg/kg of pyriproxyfen. Each dog was infested with 100 adult cat fleas ready to lay eggs after 72 hours spent feeding on cats. Dogs were infested 24 hours after treatment and then weekly during 63 days. Eggs were collected and counted 24 hours after each infestation and dogs were combed 48 hours after each infestation. Fleas were counted and removed. Collected eggs were placed in incubator to study their development in larvae and into newly emerged adults. A single treatment provided 99.7% adulticidal efficacy on fleas within 48 hours after treatment and controlled re-infestations for up to 30 days (efficacy &amp;gt;96.20%, p&amp;lt;0.05). The egg laying inhibition was over 92.3% for up to 29 days (p&amp;lt;0.05). The adult emergence inhibition remained 100% during 8 weeks after treatment and was 99.8% nine weeks after treatment (p&amp;lt;0.001).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069667"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069667"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069667; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069667]").text(description); $(".js-view-count[data-work-id=66069667]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069667; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069667']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069667, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069667]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069667,"title":"Efficacy of permethrin, dinotefuran and pyriproxyfen on adult fleas, flea eggs collection, and flea egg development following transplantation of mature female fleas (Ctenocephalides felis felis) from cats to dogs","translated_title":"","metadata":{"abstract":"A novel spot-on formulation combining permethrin, pyriproxifen and dinotefuran (Vectra 3D™ spot-on solution for dogs) was evaluated in adult Beagle dogs in a study to determine adulticidal efficacy, egg laying inhibition and viability of Ctenocephalides felis felis eggs (development and emergence of fleas from the collected eggs). Prior to treatment sixteen dogs were checked for their ability to keep fleas 24 hours after infestation and were allocated to treatment groups: 8 dogs served as untreated controls, and 8 dogs were treated once with the tested formulation. The spot on was administered respecting the laboratory recommendations at a dosage of 65-126 mg/kg of permethrin; 8.9-17.4 mg/kg of dinotefuran and 0.8-1.5mg/kg of pyriproxyfen. Each dog was infested with 100 adult cat fleas ready to lay eggs after 72 hours spent feeding on cats. Dogs were infested 24 hours after treatment and then weekly during 63 days. Eggs were collected and counted 24 hours after each infestation and dogs were combed 48 hours after each infestation. Fleas were counted and removed. Collected eggs were placed in incubator to study their development in larvae and into newly emerged adults. A single treatment provided 99.7% adulticidal efficacy on fleas within 48 hours after treatment and controlled re-infestations for up to 30 days (efficacy \u0026amp;gt;96.20%, p\u0026amp;lt;0.05). The egg laying inhibition was over 92.3% for up to 29 days (p\u0026amp;lt;0.05). The adult emergence inhibition remained 100% during 8 weeks after treatment and was 99.8% nine weeks after treatment (p\u0026amp;lt;0.001).","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Veterinary Parasitology"},"translated_abstract":"A novel spot-on formulation combining permethrin, pyriproxifen and dinotefuran (Vectra 3D™ spot-on solution for dogs) was evaluated in adult Beagle dogs in a study to determine adulticidal efficacy, egg laying inhibition and viability of Ctenocephalides felis felis eggs (development and emergence of fleas from the collected eggs). Prior to treatment sixteen dogs were checked for their ability to keep fleas 24 hours after infestation and were allocated to treatment groups: 8 dogs served as untreated controls, and 8 dogs were treated once with the tested formulation. The spot on was administered respecting the laboratory recommendations at a dosage of 65-126 mg/kg of permethrin; 8.9-17.4 mg/kg of dinotefuran and 0.8-1.5mg/kg of pyriproxyfen. Each dog was infested with 100 adult cat fleas ready to lay eggs after 72 hours spent feeding on cats. Dogs were infested 24 hours after treatment and then weekly during 63 days. Eggs were collected and counted 24 hours after each infestation and dogs were combed 48 hours after each infestation. Fleas were counted and removed. Collected eggs were placed in incubator to study their development in larvae and into newly emerged adults. A single treatment provided 99.7% adulticidal efficacy on fleas within 48 hours after treatment and controlled re-infestations for up to 30 days (efficacy \u0026amp;gt;96.20%, p\u0026amp;lt;0.05). The egg laying inhibition was over 92.3% for up to 29 days (p\u0026amp;lt;0.05). The adult emergence inhibition remained 100% during 8 weeks after treatment and was 99.8% nine weeks after treatment (p\u0026amp;lt;0.001).","internal_url":"https://www.academia.edu/66069667/Efficacy_of_permethrin_dinotefuran_and_pyriproxyfen_on_adult_fleas_flea_eggs_collection_and_flea_egg_development_following_transplantation_of_mature_female_fleas_Ctenocephalides_felis_felis_from_cats_to_dogs","translated_internal_url":"","created_at":"2021-12-26T23:44:32.950-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Efficacy_of_permethrin_dinotefuran_and_pyriproxyfen_on_adult_fleas_flea_eggs_collection_and_flea_egg_development_following_transplantation_of_mature_female_fleas_Ctenocephalides_felis_felis_from_cats_to_dogs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":10062,"name":"Siphonaptera","url":"https://www.academia.edu/Documents/in/Siphonaptera"},{"id":41088,"name":"Cats","url":"https://www.academia.edu/Documents/in/Cats"},{"id":50634,"name":"Veterinary Parasitology","url":"https://www.academia.edu/Documents/in/Veterinary_Parasitology"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":52972,"name":"Insecticides","url":"https://www.academia.edu/Documents/in/Insecticides"},{"id":98942,"name":"Ovulation","url":"https://www.academia.edu/Documents/in/Ovulation"},{"id":170652,"name":"Fisheries Sciences","url":"https://www.academia.edu/Documents/in/Fisheries_Sciences"},{"id":490260,"name":"Pyridines","url":"https://www.academia.edu/Documents/in/Pyridines"},{"id":644860,"name":"Veterinary Sciences","url":"https://www.academia.edu/Documents/in/Veterinary_Sciences"},{"id":801416,"name":"Guanidines","url":"https://www.academia.edu/Documents/in/Guanidines"},{"id":3002174,"name":"Permethrin","url":"https://www.academia.edu/Documents/in/Permethrin"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069665"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069665/Ocular_Availability_of_Gentamicin_in_Small_Animals_After_Topical_Administration_of_a_Conventional_Eye_Drop_Solution_and_a_Novel_Long_Acting_Bioadhesive_Ophthalmic_Drug_Insert"><img alt="Research paper thumbnail of Ocular Availability of Gentamicin in Small Animals After Topical Administration of a Conventional Eye Drop Solution and a Novel Long Acting Bioadhesive Ophthalmic Drug Insert" class="work-thumbnail" src="https://attachments.academia-assets.com/77406282/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069665/Ocular_Availability_of_Gentamicin_in_Small_Animals_After_Topical_Administration_of_a_Conventional_Eye_Drop_Solution_and_a_Novel_Long_Acting_Bioadhesive_Ophthalmic_Drug_Insert">Ocular Availability of Gentamicin in Small Animals After Topical Administration of a Conventional Eye Drop Solution and a Novel Long Acting Bioadhesive Ophthalmic Drug Insert</a></div><div class="wp-workCard_item"><span>Pharmaceutical Research</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose. Gentamicin eye drop solutions have a short precorneal residence time. The present study ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose. Gentamicin eye drop solutions have a short precorneal residence time. The present study investigates the effect of gentamicin using a new long acting delivery Bioadhesive Ophthalmic Insert (BODI) in healthy dogs and rabbits and compares the results with a conventional regimen using an eye drop solution.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ff94f9c1f1e2cc52beb69e70fe1ca333" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77406282,"asset_id":66069665,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77406282/download_file?st=MTczMzAyMDQ0Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069665"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069665"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069665; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069665]").text(description); $(".js-view-count[data-work-id=66069665]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069665; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069665']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069665, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ff94f9c1f1e2cc52beb69e70fe1ca333" } } $('.js-work-strip[data-work-id=66069665]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069665,"title":"Ocular Availability of Gentamicin in Small Animals After Topical Administration of a Conventional Eye Drop Solution and a Novel Long Acting Bioadhesive Ophthalmic Drug Insert","translated_title":"","metadata":{"abstract":"Purpose. Gentamicin eye drop solutions have a short precorneal residence time. The present study investigates the effect of gentamicin using a new long acting delivery Bioadhesive Ophthalmic Insert (BODI) in healthy dogs and rabbits and compares the results with a conventional regimen using an eye drop solution.","publication_date":{"day":null,"month":null,"year":1995,"errors":{}},"publication_name":"Pharmaceutical Research"},"translated_abstract":"Purpose. Gentamicin eye drop solutions have a short precorneal residence time. The present study investigates the effect of gentamicin using a new long acting delivery Bioadhesive Ophthalmic Insert (BODI) in healthy dogs and rabbits and compares the results with a conventional regimen using an eye drop solution.","internal_url":"https://www.academia.edu/66069665/Ocular_Availability_of_Gentamicin_in_Small_Animals_After_Topical_Administration_of_a_Conventional_Eye_Drop_Solution_and_a_Novel_Long_Acting_Bioadhesive_Ophthalmic_Drug_Insert","translated_internal_url":"","created_at":"2021-12-26T23:44:32.770-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":77406282,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406282/thumbnails/1.jpg","file_name":"a_3A101624252822220211226-20106-zr2k4o.pdf","download_url":"https://www.academia.edu/attachments/77406282/download_file?st=MTczMzAyMDQ0Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Ocular_Availability_of_Gentamicin_in_Sma.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406282/a_3A101624252822220211226-20106-zr2k4o-libre.pdf?1640595264=\u0026response-content-disposition=attachment%3B+filename%3DOcular_Availability_of_Gentamicin_in_Sma.pdf\u0026Expires=1733024046\u0026Signature=PMLH6i0Bin9Pf32r~kzGIi95i9jcCG4hVLp0MVS72jn9hJPWLQdH14AgK3JARVKy9tUlNN-CLh4is569G0Fdp-C1VGAwDyoc9jphR8rWy10vXMkyqMMPNb-szXWv21xAk5eO0SNZWq9t-3VJ1UDqXHp0ES46adRUw-raBtt9i9dQ70I66OOX1l2b4rdWRIi0Hl~tScqNAmQj-GuM71TPeM3xjxZJ30gtfeBCukwd9Yo5novSHF5t5AT9Br6hk5jkCNta700ILwMNj5fi7oUX2rp3D-Rjeuk9Nt0X6Op-9WfIMUsORbJvIPa4Nanu6Ww1VzvyKCMtkPlFOZsK1vfGSw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Ocular_Availability_of_Gentamicin_in_Small_Animals_After_Topical_Administration_of_a_Conventional_Eye_Drop_Solution_and_a_Novel_Long_Acting_Bioadhesive_Ophthalmic_Drug_Insert","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[{"id":77406282,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406282/thumbnails/1.jpg","file_name":"a_3A101624252822220211226-20106-zr2k4o.pdf","download_url":"https://www.academia.edu/attachments/77406282/download_file?st=MTczMzAyMDQ0Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Ocular_Availability_of_Gentamicin_in_Sma.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406282/a_3A101624252822220211226-20106-zr2k4o-libre.pdf?1640595264=\u0026response-content-disposition=attachment%3B+filename%3DOcular_Availability_of_Gentamicin_in_Sma.pdf\u0026Expires=1733024046\u0026Signature=PMLH6i0Bin9Pf32r~kzGIi95i9jcCG4hVLp0MVS72jn9hJPWLQdH14AgK3JARVKy9tUlNN-CLh4is569G0Fdp-C1VGAwDyoc9jphR8rWy10vXMkyqMMPNb-szXWv21xAk5eO0SNZWq9t-3VJ1UDqXHp0ES46adRUw-raBtt9i9dQ70I66OOX1l2b4rdWRIi0Hl~tScqNAmQj-GuM71TPeM3xjxZJ30gtfeBCukwd9Yo5novSHF5t5AT9Br6hk5jkCNta700ILwMNj5fi7oUX2rp3D-Rjeuk9Nt0X6Op-9WfIMUsORbJvIPa4Nanu6Ww1VzvyKCMtkPlFOZsK1vfGSw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":95655,"name":"Pharmaceutical","url":"https://www.academia.edu/Documents/in/Pharmaceutical"},{"id":113903,"name":"Bacteria","url":"https://www.academia.edu/Documents/in/Bacteria"},{"id":228471,"name":"Tears","url":"https://www.academia.edu/Documents/in/Tears"},{"id":245634,"name":"Eye","url":"https://www.academia.edu/Documents/in/Eye"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents"},{"id":784076,"name":"Species Specificity","url":"https://www.academia.edu/Documents/in/Species_Specificity"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"},{"id":984993,"name":"Residence Time","url":"https://www.academia.edu/Documents/in/Residence_Time"},{"id":1109769,"name":"Biological Assay","url":"https://www.academia.edu/Documents/in/Biological_Assay"},{"id":1136192,"name":"Biological Availability","url":"https://www.academia.edu/Documents/in/Biological_Availability"},{"id":1137112,"name":"Ophthalmic Solutions","url":"https://www.academia.edu/Documents/in/Ophthalmic_Solutions"},{"id":2467505,"name":"Gentamicins","url":"https://www.academia.edu/Documents/in/Gentamicins"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"},{"id":3986399,"name":"tissue adhesives","url":"https://www.academia.edu/Documents/in/tissue_adhesives"}],"urls":[{"id":15723560,"url":"http://www.springerlink.com/content/ewqwgmcm6dmvaqux"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069664"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069664/Efficacy_of_dinotefuran_permethrin_and_pyriproxyfen_combination_spot_on_on_dogs_against_Phlebotomus_perniciosus_and_Ctenocephalides_canis"><img alt="Research paper thumbnail of Efficacy of dinotefuran, permethrin and pyriproxyfen combination spot-on on dogs against Phlebotomus perniciosus and Ctenocephalides canis" class="work-thumbnail" src="https://attachments.academia-assets.com/77406273/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069664/Efficacy_of_dinotefuran_permethrin_and_pyriproxyfen_combination_spot_on_on_dogs_against_Phlebotomus_perniciosus_and_Ctenocephalides_canis">Efficacy of dinotefuran, permethrin and pyriproxyfen combination spot-on on dogs against Phlebotomus perniciosus and Ctenocephalides canis</a></div><div class="wp-workCard_item"><span>Parasitology Research</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="783155eddd4964f718ece7c0f0710688" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77406273,"asset_id":66069664,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77406273/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069664"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069664"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069664; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069664]").text(description); $(".js-view-count[data-work-id=66069664]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069664; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069664']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069664, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "783155eddd4964f718ece7c0f0710688" } } $('.js-work-strip[data-work-id=66069664]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069664,"title":"Efficacy of dinotefuran, permethrin and pyriproxyfen combination spot-on on dogs against Phlebotomus perniciosus and Ctenocephalides canis","translated_title":"","metadata":{"publisher":"Springer Nature","grobid_abstract":"This study was conducted to evaluate the efficacy of a new topical ectoparasiticidal spot-on containing 4.95 % dinotefuran (w /w), 36.08 % permethrin (w/w) and 0.44 % pyriproxyfen (w/w) (Vectra 3D™, Ceva, Libourne, France) against Portuguese strain of Phlebotomus perniciosus and a French strain of Ctenocephalides canis in dogs. Twelve beagle dogs were exposed for 1 h to 100 P. perniciosus on day 6 for allocation in two groups. One group was treated on day 0, and the other group was the control group. The dogs were exposed for 1 h to 100 P. perniciosus on days 1, 7, 14, 21 and 28. After each sandfly challenge, the same dogs were infested with 100 C. canis. Counts of living fleas were determined 48 h after infestation on days 4,","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Parasitology Research","grobid_abstract_attachment_id":77406273},"translated_abstract":null,"internal_url":"https://www.academia.edu/66069664/Efficacy_of_dinotefuran_permethrin_and_pyriproxyfen_combination_spot_on_on_dogs_against_Phlebotomus_perniciosus_and_Ctenocephalides_canis","translated_internal_url":"","created_at":"2021-12-26T23:44:32.652-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":77406273,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406273/thumbnails/1.jpg","file_name":"pmc3825486.pdf","download_url":"https://www.academia.edu/attachments/77406273/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Efficacy_of_dinotefuran_permethrin_and_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406273/pmc3825486-libre.pdf?1640595266=\u0026response-content-disposition=attachment%3B+filename%3DEfficacy_of_dinotefuran_permethrin_and_p.pdf\u0026Expires=1733024047\u0026Signature=DimV8DIh6D-VGSr3B-i4ExpwMiTr8s0j-g0UZQOSuZy8or2rt-jYyFgG9C98aenXss65KDQvyG2NhKE7KBFdLxP-5NIkNyUEKM1jciJN0NGbjP0uWmjobA8c7bBnY5YiGDu3uQMwiRjBBZA0ehMq7z12DiWyaojFrNcl93e~eu6G-2vZT67s7~oGDs-L9ca2Yz5~G5~Dtdi1rZ0qt73SE3ZNxve8U4QD~AfvZParynFu0GKoXX-crXwm81h5v2u6ltRQuKzR5~nb3u5auXxS6Pnlc9l~6IzFHRWOfHfz2KJR~cIzV-6LQyVeuSW-hZ-wd3EO0O5FlcQDLeVTwUu2Nw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Efficacy_of_dinotefuran_permethrin_and_pyriproxyfen_combination_spot_on_on_dogs_against_Phlebotomus_perniciosus_and_Ctenocephalides_canis","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[{"id":77406273,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406273/thumbnails/1.jpg","file_name":"pmc3825486.pdf","download_url":"https://www.academia.edu/attachments/77406273/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Efficacy_of_dinotefuran_permethrin_and_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406273/pmc3825486-libre.pdf?1640595266=\u0026response-content-disposition=attachment%3B+filename%3DEfficacy_of_dinotefuran_permethrin_and_p.pdf\u0026Expires=1733024047\u0026Signature=DimV8DIh6D-VGSr3B-i4ExpwMiTr8s0j-g0UZQOSuZy8or2rt-jYyFgG9C98aenXss65KDQvyG2NhKE7KBFdLxP-5NIkNyUEKM1jciJN0NGbjP0uWmjobA8c7bBnY5YiGDu3uQMwiRjBBZA0ehMq7z12DiWyaojFrNcl93e~eu6G-2vZT67s7~oGDs-L9ca2Yz5~G5~Dtdi1rZ0qt73SE3ZNxve8U4QD~AfvZParynFu0GKoXX-crXwm81h5v2u6ltRQuKzR5~nb3u5auXxS6Pnlc9l~6IzFHRWOfHfz2KJR~cIzV-6LQyVeuSW-hZ-wd3EO0O5FlcQDLeVTwUu2Nw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":164,"name":"Parasitology","url":"https://www.academia.edu/Documents/in/Parasitology"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis"},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":52972,"name":"Insecticides","url":"https://www.academia.edu/Documents/in/Insecticides"},{"id":490260,"name":"Pyridines","url":"https://www.academia.edu/Documents/in/Pyridines"},{"id":494759,"name":"Flea Infestations","url":"https://www.academia.edu/Documents/in/Flea_Infestations"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy"},{"id":644860,"name":"Veterinary Sciences","url":"https://www.academia.edu/Documents/in/Veterinary_Sciences"},{"id":801416,"name":"Guanidines","url":"https://www.academia.edu/Documents/in/Guanidines"},{"id":1552635,"name":"Phlebotomus","url":"https://www.academia.edu/Documents/in/Phlebotomus"},{"id":1825973,"name":"Ctenocephalides","url":"https://www.academia.edu/Documents/in/Ctenocephalides"},{"id":3002174,"name":"Permethrin","url":"https://www.academia.edu/Documents/in/Permethrin"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069662"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069662/Efficacy_of_Spironolactone_on_Survival_in_Dogs_with_Naturally_Occurring_Mitral_Regurgitation_Caused_by_Myxomatous_Mitral_Valve_Disease"><img alt="Research paper thumbnail of Efficacy of Spironolactone on Survival in Dogs with Naturally Occurring Mitral Regurgitation Caused by Myxomatous Mitral Valve Disease" class="work-thumbnail" src="https://attachments.academia-assets.com/77406278/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069662/Efficacy_of_Spironolactone_on_Survival_in_Dogs_with_Naturally_Occurring_Mitral_Regurgitation_Caused_by_Myxomatous_Mitral_Valve_Disease">Efficacy of Spironolactone on Survival in Dogs with Naturally Occurring Mitral Regurgitation Caused by Myxomatous Mitral Valve Disease</a></div><div class="wp-workCard_item"><span>Journal of Veterinary Internal Medicine</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9922183b052709fe06bd76cfc281bd15" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77406278,"asset_id":66069662,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77406278/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069662"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069662"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069662; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069662]").text(description); $(".js-view-count[data-work-id=66069662]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069662; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069662']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069662, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9922183b052709fe06bd76cfc281bd15" } } $('.js-work-strip[data-work-id=66069662]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069662,"title":"Efficacy of Spironolactone on Survival in Dogs with Naturally Occurring Mitral Regurgitation Caused by Myxomatous Mitral Valve Disease","translated_title":"","metadata":{"publisher":"Wiley-Blackwell","grobid_abstract":"Background: Spironolactone, an aldosterone antagonist, has been demonstrated to decrease mortality in human patients when added to other cardiac therapies. Hypothesis: Spironolactone in addition to conventional therapy increases survival compared with conventional therapy in dogs with naturally occurring myxomatous mitral valve disease (MMVD). Animals: Between February 2003 and March 2005, 221 dogs were recruited in Europe. Nine dogs were excluded from analysis, leaving 212 dogs with moderate to severe mitral regurgitation (MR) caused by MMVD (International Small Animal Cardiac Health Council classification classes II [n 5 190] and III [n 5 21]). Methods: Double-blinded, field study conducted with dogs randomized to receive either spironolactone (2 mg/kg once a day) or placebo in addition to conventional therapy (angiotensin converting enzyme inhibitor, plus furosemide and digoxin if needed). Primary endpoint was a composite of cardiac-related death, euthanasia, or severe worsening of MR. Results: Primary endpoint reached by 11/102 dogs (10.8%) in the spironolactone group (6 deaths, 5 worsening) versus 28/ 110 (25.5%) in control group (14 deaths, 8 euthanasia, 6 worsening). Risk of reaching the composite endpoint significantly decreased by 55% (hazard ratio [HR] 5 0.45; 95% confidence limits [CL], 0.22-0.90; log rank test, P 5 .017). Risk of cardiacrelated death or euthanasia significantly reduced by 69% (HR 5 0.31; 95% CL, 0.13-0.76; P 5 .0071). Number of dogs not completing the study for cardiac and other miscellaneous reasons similar in spironolactone (67/102) and control groups (66/110). Conclusion and Clinical Importance: Spironolactone added to conventional cardiac therapy decreases the risk of reaching the primary endpoint (ie, cardiac-related death, euthanasia, or severe worsening) in dogs with moderate to severe MR caused by MMVD.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of Veterinary Internal Medicine","grobid_abstract_attachment_id":77406278},"translated_abstract":null,"internal_url":"https://www.academia.edu/66069662/Efficacy_of_Spironolactone_on_Survival_in_Dogs_with_Naturally_Occurring_Mitral_Regurgitation_Caused_by_Myxomatous_Mitral_Valve_Disease","translated_internal_url":"","created_at":"2021-12-26T23:44:32.536-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":77406278,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406278/thumbnails/1.jpg","file_name":"Efficacy_20of_20Spironolactone_20on_20Survival_20in_20Dogs_20with_20Naturally.pdf","download_url":"https://www.academia.edu/attachments/77406278/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Efficacy_of_Spironolactone_on_Survival_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406278/Efficacy_20of_20Spironolactone_20on_20Survival_20in_20Dogs_20with_20Naturally-libre.pdf?1640595265=\u0026response-content-disposition=attachment%3B+filename%3DEfficacy_of_Spironolactone_on_Survival_i.pdf\u0026Expires=1733024047\u0026Signature=MvyleUPEP-mAs3evraLMcVyzDnKZ~gybQh0ZUc6Nqzu4K2bFFDXan2K0ZbARN3ZLKaYMIaePmD21hbF2EY58zbP1f03xtZ82q6S-C6rb8oRtbnVdGA7L36vTGX-F-acygsImI0IyrwXcvwtF3AlaREEJQMat9VwiJlXdZzUakpKNjaNJLmHxe-66srrulj8PqpbJm9X4lwZHj61HTHsV7Ax~YqMtlRyaXTZ1Ae~OQTMEaX~QgrfFJ-DMa-t27sl3eAdzB-GKQUVSPp9Vla9HoEvUJXFJS2kNM8CVEb~LySDYXBw2mHpUh3~RMUYclJh8Bv~uAZdBwTrsHRi8d0IJAg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Efficacy_of_Spironolactone_on_Survival_in_Dogs_with_Naturally_Occurring_Mitral_Regurgitation_Caused_by_Myxomatous_Mitral_Valve_Disease","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[{"id":77406278,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406278/thumbnails/1.jpg","file_name":"Efficacy_20of_20Spironolactone_20on_20Survival_20in_20Dogs_20with_20Naturally.pdf","download_url":"https://www.academia.edu/attachments/77406278/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Efficacy_of_Spironolactone_on_Survival_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406278/Efficacy_20of_20Spironolactone_20on_20Survival_20in_20Dogs_20with_20Naturally-libre.pdf?1640595265=\u0026response-content-disposition=attachment%3B+filename%3DEfficacy_of_Spironolactone_on_Survival_i.pdf\u0026Expires=1733024047\u0026Signature=MvyleUPEP-mAs3evraLMcVyzDnKZ~gybQh0ZUc6Nqzu4K2bFFDXan2K0ZbARN3ZLKaYMIaePmD21hbF2EY58zbP1f03xtZ82q6S-C6rb8oRtbnVdGA7L36vTGX-F-acygsImI0IyrwXcvwtF3AlaREEJQMat9VwiJlXdZzUakpKNjaNJLmHxe-66srrulj8PqpbJm9X4lwZHj61HTHsV7Ax~YqMtlRyaXTZ1Ae~OQTMEaX~QgrfFJ-DMa-t27sl3eAdzB-GKQUVSPp9Vla9HoEvUJXFJS2kNM8CVEb~LySDYXBw2mHpUh3~RMUYclJh8Bv~uAZdBwTrsHRi8d0IJAg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":89995,"name":"Diuretics","url":"https://www.academia.edu/Documents/in/Diuretics"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy"},{"id":644860,"name":"Veterinary Sciences","url":"https://www.academia.edu/Documents/in/Veterinary_Sciences"},{"id":977495,"name":"Digoxin","url":"https://www.academia.edu/Documents/in/Digoxin"},{"id":1135799,"name":"Furosemide","url":"https://www.academia.edu/Documents/in/Furosemide"},{"id":1227768,"name":"Angiotensin Converting Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme_Inhibitors"},{"id":1272981,"name":"Proportional Hazards Models","url":"https://www.academia.edu/Documents/in/Proportional_Hazards_Models"},{"id":1749710,"name":"Veterinary Internal Medicine","url":"https://www.academia.edu/Documents/in/Veterinary_Internal_Medicine"},{"id":2057471,"name":"Mitral regurgitation","url":"https://www.academia.edu/Documents/in/Mitral_regurgitation"},{"id":2990585,"name":"mitral valve disease","url":"https://www.academia.edu/Documents/in/mitral_valve_disease"},{"id":3329465,"name":"Spironolactone","url":"https://www.academia.edu/Documents/in/Spironolactone"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069661"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069661/Evaluation_of_Soluble_Bioadhesive_Ophthalmic_Drug_Inserts_BODI_for_Prolonged_Release_of_Gentamicin_Lachrymal_Pharmacokinetics_and_Ocular_Tolerance"><img alt="Research paper thumbnail of Evaluation of Soluble Bioadhesive Ophthalmic Drug Inserts (BODI®) for Prolonged Release of Gentamicin: Lachrymal Pharmacokinetics and Ocular Tolerance" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069661/Evaluation_of_Soluble_Bioadhesive_Ophthalmic_Drug_Inserts_BODI_for_Prolonged_Release_of_Gentamicin_Lachrymal_Pharmacokinetics_and_Ocular_Tolerance">Evaluation of Soluble Bioadhesive Ophthalmic Drug Inserts (BODI®) for Prolonged Release of Gentamicin: Lachrymal Pharmacokinetics and Ocular Tolerance</a></div><div class="wp-workCard_item"><span>Journal of Ocular Pharmacology and Therapeutics</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The purpose of this investigation was the evaluation of Bioadhesive Ophthalmic Drug Inserts (BODI...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The purpose of this investigation was the evaluation of Bioadhesive Ophthalmic Drug Inserts (BODI) for prolonged release of gentamicin sulfate (GS) in tears. The BODIs (length 5.0 mm, diameter 2.0 mm, weight 20.5 mg, average GS content 5.0 mg) were prepared by extrusion of a mixture based on hydroxypropylcellulose (HPC), ethylcellulose (EC) and carbomer. Two methods were tested to prolong the release of GS in tears: (1) preliminary treatment of GS and (2) use of a less hydrophilic polymer than HPC, hydroxypropylmethylcellulose (HPMC), as a vehicle constituent. The preliminary treatment consisted of the formation of a GS/cellulose acetate phthalate (CAP) solid dispersion (ratio GS/CAP: 10/6) made in acetonic medium, and in the coating of GS/EC granules (GS/EC ratio: 10/0.5) with an aqueous dispersion of CAP, to form a GS/EC/CAP coprecipitate (GS/EC/CAP ratio: 10/0.5/6). Inserts containing GS/CAP solid dispersion, GS/EC/CAP coprecipitate and HPMC resulted in improved time of efficacy (t(eff)) (43.8, 23.3, and 33.1 h, respectively), when compared to inserts containing GS without preliminary treatment (t(eff) = 11.9 h). A high irritation level was observed for inserts containing the GS/EC/CAP and HPMC. A relation between t(eff) and irritation score was established, emphasizing the importance of irritability as a factor during the evaluation of the potential of these systems.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069661"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069661"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069661; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069661]").text(description); $(".js-view-count[data-work-id=66069661]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069661; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069661']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069661, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069661]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069661,"title":"Evaluation of Soluble Bioadhesive Ophthalmic Drug Inserts (BODI®) for Prolonged Release of Gentamicin: Lachrymal Pharmacokinetics and Ocular Tolerance","translated_title":"","metadata":{"abstract":"The purpose of this investigation was the evaluation of Bioadhesive Ophthalmic Drug Inserts (BODI) for prolonged release of gentamicin sulfate (GS) in tears. The BODIs (length 5.0 mm, diameter 2.0 mm, weight 20.5 mg, average GS content 5.0 mg) were prepared by extrusion of a mixture based on hydroxypropylcellulose (HPC), ethylcellulose (EC) and carbomer. Two methods were tested to prolong the release of GS in tears: (1) preliminary treatment of GS and (2) use of a less hydrophilic polymer than HPC, hydroxypropylmethylcellulose (HPMC), as a vehicle constituent. The preliminary treatment consisted of the formation of a GS/cellulose acetate phthalate (CAP) solid dispersion (ratio GS/CAP: 10/6) made in acetonic medium, and in the coating of GS/EC granules (GS/EC ratio: 10/0.5) with an aqueous dispersion of CAP, to form a GS/EC/CAP coprecipitate (GS/EC/CAP ratio: 10/0.5/6). Inserts containing GS/CAP solid dispersion, GS/EC/CAP coprecipitate and HPMC resulted in improved time of efficacy (t(eff)) (43.8, 23.3, and 33.1 h, respectively), when compared to inserts containing GS without preliminary treatment (t(eff) = 11.9 h). A high irritation level was observed for inserts containing the GS/EC/CAP and HPMC. A relation between t(eff) and irritation score was established, emphasizing the importance of irritability as a factor during the evaluation of the potential of these systems.","publisher":"Mary Ann Liebert Inc","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Journal of Ocular Pharmacology and Therapeutics"},"translated_abstract":"The purpose of this investigation was the evaluation of Bioadhesive Ophthalmic Drug Inserts (BODI) for prolonged release of gentamicin sulfate (GS) in tears. The BODIs (length 5.0 mm, diameter 2.0 mm, weight 20.5 mg, average GS content 5.0 mg) were prepared by extrusion of a mixture based on hydroxypropylcellulose (HPC), ethylcellulose (EC) and carbomer. Two methods were tested to prolong the release of GS in tears: (1) preliminary treatment of GS and (2) use of a less hydrophilic polymer than HPC, hydroxypropylmethylcellulose (HPMC), as a vehicle constituent. The preliminary treatment consisted of the formation of a GS/cellulose acetate phthalate (CAP) solid dispersion (ratio GS/CAP: 10/6) made in acetonic medium, and in the coating of GS/EC granules (GS/EC ratio: 10/0.5) with an aqueous dispersion of CAP, to form a GS/EC/CAP coprecipitate (GS/EC/CAP ratio: 10/0.5/6). Inserts containing GS/CAP solid dispersion, GS/EC/CAP coprecipitate and HPMC resulted in improved time of efficacy (t(eff)) (43.8, 23.3, and 33.1 h, respectively), when compared to inserts containing GS without preliminary treatment (t(eff) = 11.9 h). A high irritation level was observed for inserts containing the GS/EC/CAP and HPMC. A relation between t(eff) and irritation score was established, emphasizing the importance of irritability as a factor during the evaluation of the potential of these systems.","internal_url":"https://www.academia.edu/66069661/Evaluation_of_Soluble_Bioadhesive_Ophthalmic_Drug_Inserts_BODI_for_Prolonged_Release_of_Gentamicin_Lachrymal_Pharmacokinetics_and_Ocular_Tolerance","translated_internal_url":"","created_at":"2021-12-26T23:44:32.421-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Evaluation_of_Soluble_Bioadhesive_Ophthalmic_Drug_Inserts_BODI_for_Prolonged_Release_of_Gentamicin_Lachrymal_Pharmacokinetics_and_Ocular_Tolerance","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":228471,"name":"Tears","url":"https://www.academia.edu/Documents/in/Tears"},{"id":245634,"name":"Eye","url":"https://www.academia.edu/Documents/in/Eye"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents"},{"id":359001,"name":"Optometry and Ophthalmology","url":"https://www.academia.edu/Documents/in/Optometry_and_Ophthalmology"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"},{"id":1136192,"name":"Biological Availability","url":"https://www.academia.edu/Documents/in/Biological_Availability"},{"id":1137112,"name":"Ophthalmic Solutions","url":"https://www.academia.edu/Documents/in/Ophthalmic_Solutions"},{"id":1309706,"name":"Area Under Curve","url":"https://www.academia.edu/Documents/in/Area_Under_Curve"},{"id":2467505,"name":"Gentamicins","url":"https://www.academia.edu/Documents/in/Gentamicins"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"},{"id":3986399,"name":"tissue adhesives","url":"https://www.academia.edu/Documents/in/tissue_adhesives"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069660"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069660/Long_acting_soluble_bioadhesive_ophthalmic_drug_insert_BODI_containing_gentamicin_for_veterinary_use_optimization_and_clinical_investigation"><img alt="Research paper thumbnail of Long-acting soluble bioadhesive ophthalmic drug insert (BODI) containing gentamicin for veterinary use: optimization and clinical investigation" class="work-thumbnail" src="https://attachments.academia-assets.com/77406332/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069660/Long_acting_soluble_bioadhesive_ophthalmic_drug_insert_BODI_containing_gentamicin_for_veterinary_use_optimization_and_clinical_investigation">Long-acting soluble bioadhesive ophthalmic drug insert (BODI) containing gentamicin for veterinary use: optimization and clinical investigation</a></div><div class="wp-workCard_item"><span>Journal of Controlled Release</span><span>, 1995</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cec668ba83586b0813231b16a62f035d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77406332,"asset_id":66069660,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77406332/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069660"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069660"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069660; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069660]").text(description); $(".js-view-count[data-work-id=66069660]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069660; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069660']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069660, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cec668ba83586b0813231b16a62f035d" } } $('.js-work-strip[data-work-id=66069660]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069660,"title":"Long-acting soluble bioadhesive ophthalmic drug insert (BODI) containing gentamicin for veterinary use: optimization and clinical investigation","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"In animal health care, current therapeutic regimens for severe external infections require repeated instillations of antibiotic eye drop solutions. The aim of this work is to drastically decrease the frequency of instillations by developing a long-acting ophthalmic insert. Ophthalmic inserts based on mixtures of hydroxypropyl cellulose, ethyl cellulose, poly(acrylic) acid and 25.0% (w/w) of gentamicin sulfate either combined with cellulose acetate phthalate or not were prepared using a specially designed ram extruder. The content of each component was optimized by evaluating tolerance and drug release in rabbits. Preliminary in vivo assays in rabbits led to a formulation with the favourable characteristics needed. These inserts were tested in dogs for drug release and compared with a commercially sold collyrium. The results show that the inserts ensure effective gentamicin levels over 72 h with variation coefficients between 2 and 10%. These results are compared with those obtained with the eye drop solution (0.3%), which provides effective concentrations lasting less than 15 min with variation coefficients ranging from 63-96%. These soluble Bioadhesive Ophthalmic Drug Inserts (BODI) can be considered as a promising new ophthalmic delivery concept specifically designed for animal health care.","publication_date":{"day":null,"month":null,"year":1995,"errors":{}},"publication_name":"Journal of Controlled Release","grobid_abstract_attachment_id":77406332},"translated_abstract":null,"internal_url":"https://www.academia.edu/66069660/Long_acting_soluble_bioadhesive_ophthalmic_drug_insert_BODI_containing_gentamicin_for_veterinary_use_optimization_and_clinical_investigation","translated_internal_url":"","created_at":"2021-12-26T23:44:32.305-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":77406332,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406332/thumbnails/1.jpg","file_name":"0168-3659_2894_2900096-d20211226-23550-j6u10r.pdf","download_url":"https://www.academia.edu/attachments/77406332/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Long_acting_soluble_bioadhesive_ophthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406332/0168-3659_2894_2900096-d20211226-23550-j6u10r-libre.pdf?1640595262=\u0026response-content-disposition=attachment%3B+filename%3DLong_acting_soluble_bioadhesive_ophthalm.pdf\u0026Expires=1733024047\u0026Signature=Mlr1e318HiPT-KgUTodrpusAlpPSFLXYxeQu19vWnd7feAHZQuIeZ4BDIIgXj0o4YNWX5ujvxI~OT5XRhE2TZowDw3h2Zu28Ffew7x~-F-PYCpe-Wuq5f5jvTSwqH2ss9uSs1w1RohOlkojVGeYHzXG4ByUIYqvYX2n-gYzqHCFY3G3DW1KvffqL7hTfYI0OrVJ8pqv0MwqcR5KY7s8H6-x4S~HSGgr8LMKttmbhMxGVgVN01NlVH-but4FcLusVP3DSOitIK9GxkPhhiCG50RHDOxeRrJ7ylykFiQvrubWtW2y0S7UoqYC~lSRMTqtW0IqD1-APkWlLtJzAhAls2w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Long_acting_soluble_bioadhesive_ophthalmic_drug_insert_BODI_containing_gentamicin_for_veterinary_use_optimization_and_clinical_investigation","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[{"id":77406332,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406332/thumbnails/1.jpg","file_name":"0168-3659_2894_2900096-d20211226-23550-j6u10r.pdf","download_url":"https://www.academia.edu/attachments/77406332/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Long_acting_soluble_bioadhesive_ophthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406332/0168-3659_2894_2900096-d20211226-23550-j6u10r-libre.pdf?1640595262=\u0026response-content-disposition=attachment%3B+filename%3DLong_acting_soluble_bioadhesive_ophthalm.pdf\u0026Expires=1733024047\u0026Signature=Mlr1e318HiPT-KgUTodrpusAlpPSFLXYxeQu19vWnd7feAHZQuIeZ4BDIIgXj0o4YNWX5ujvxI~OT5XRhE2TZowDw3h2Zu28Ffew7x~-F-PYCpe-Wuq5f5jvTSwqH2ss9uSs1w1RohOlkojVGeYHzXG4ByUIYqvYX2n-gYzqHCFY3G3DW1KvffqL7hTfYI0OrVJ8pqv0MwqcR5KY7s8H6-x4S~HSGgr8LMKttmbhMxGVgVN01NlVH-but4FcLusVP3DSOitIK9GxkPhhiCG50RHDOxeRrJ7ylykFiQvrubWtW2y0S7UoqYC~lSRMTqtW0IqD1-APkWlLtJzAhAls2w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":657,"name":"Veterinary Medicine","url":"https://www.academia.edu/Documents/in/Veterinary_Medicine"},{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery"},{"id":28505,"name":"Adhesion","url":"https://www.academia.edu/Documents/in/Adhesion"},{"id":41747,"name":"Dosage Form","url":"https://www.academia.edu/Documents/in/Dosage_Form"},{"id":64660,"name":"Controlled release","url":"https://www.academia.edu/Documents/in/Controlled_release"},{"id":119176,"name":"Animal health","url":"https://www.academia.edu/Documents/in/Animal_health"},{"id":245634,"name":"Eye","url":"https://www.academia.edu/Documents/in/Eye"},{"id":1136003,"name":"Cellulose Acetate","url":"https://www.academia.edu/Documents/in/Cellulose_Acetate"},{"id":1139957,"name":"Drug Release","url":"https://www.academia.edu/Documents/in/Drug_Release"},{"id":1303345,"name":"Poly Acrylic Acid","url":"https://www.academia.edu/Documents/in/Poly_Acrylic_Acid"},{"id":2282998,"name":"Insert","url":"https://www.academia.edu/Documents/in/Insert"},{"id":2296520,"name":"Ethyl Cellulose","url":"https://www.academia.edu/Documents/in/Ethyl_Cellulose-1"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069659"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069659/Cephradin_plaga_microspheres_for_sustained_delivery_to_cattle"><img alt="Research paper thumbnail of Cephradin-plaga microspheres for sustained delivery to cattle" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069659/Cephradin_plaga_microspheres_for_sustained_delivery_to_cattle">Cephradin-plaga microspheres for sustained delivery to cattle</a></div><div class="wp-workCard_item"><span>Journal of microencapsulation</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the field of controlled drug delivery, most of the reported work is aimed at introducing new s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the field of controlled drug delivery, most of the reported work is aimed at introducing new systems, or at providing basic information on the critical parameters which affect release profiles in vitro and occasionally in vivo. The situation is totally different when one wants to ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069659"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069659"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069659; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069659]").text(description); $(".js-view-count[data-work-id=66069659]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069659; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069659']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069659, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069659]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069659,"title":"Cephradin-plaga microspheres for sustained delivery to cattle","translated_title":"","metadata":{"abstract":"In the field of controlled drug delivery, most of the reported work is aimed at introducing new systems, or at providing basic information on the critical parameters which affect release profiles in vitro and occasionally in vivo. The situation is totally different when one wants to ...","publisher":"informahealthcare.com","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Journal of microencapsulation"},"translated_abstract":"In the field of controlled drug delivery, most of the reported work is aimed at introducing new systems, or at providing basic information on the critical parameters which affect release profiles in vitro and occasionally in vivo. The situation is totally different when one wants to ...","internal_url":"https://www.academia.edu/66069659/Cephradin_plaga_microspheres_for_sustained_delivery_to_cattle","translated_internal_url":"","created_at":"2021-12-26T23:44:32.139-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Cephradin_plaga_microspheres_for_sustained_delivery_to_cattle","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":511,"name":"Materials Science","url":"https://www.academia.edu/Documents/in/Materials_Science"},{"id":532,"name":"Physical Chemistry","url":"https://www.academia.edu/Documents/in/Physical_Chemistry"},{"id":21466,"name":"Polymers","url":"https://www.academia.edu/Documents/in/Polymers"},{"id":23390,"name":"Pharmaceutical Chemistry","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":57800,"name":"Microencapsulation","url":"https://www.academia.edu/Documents/in/Microencapsulation"},{"id":161226,"name":"Cephalosporins","url":"https://www.academia.edu/Documents/in/Cephalosporins"},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"},{"id":794074,"name":"Microspheres","url":"https://www.academia.edu/Documents/in/Microspheres"},{"id":1074508,"name":"Lactic Acid","url":"https://www.academia.edu/Documents/in/Lactic_Acid"},{"id":1137107,"name":"Delayed-Action Preparations","url":"https://www.academia.edu/Documents/in/Delayed-Action_Preparations"},{"id":1745595,"name":"Solvents","url":"https://www.academia.edu/Documents/in/Solvents"},{"id":1842148,"name":"Cephradine","url":"https://www.academia.edu/Documents/in/Cephradine"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":15723559,"url":"http://direct.bl.uk/research/5E/32/RN057045980.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069658"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069658/Labile_conjugation_of_a_hydrophilic_drug_to_PLA_oligomers_to_modify_a_drug_delivery_system_cephradin_in_a_PLAGA_matrix"><img alt="Research paper thumbnail of Labile conjugation of a hydrophilic drug to PLA oligomers to modify a drug delivery system: cephradin in a PLAGA matrix" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069658/Labile_conjugation_of_a_hydrophilic_drug_to_PLA_oligomers_to_modify_a_drug_delivery_system_cephradin_in_a_PLAGA_matrix">Labile conjugation of a hydrophilic drug to PLA oligomers to modify a drug delivery system: cephradin in a PLAGA matrix</a></div><div class="wp-workCard_item"><span>Journal of …</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficult because of poor entrapment yield and/or fast release, depending on the microsphere fabrication method. In order to counter the effects of drug hydrophilicity, it is proposed to ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069658"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069658"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069658; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069658]").text(description); $(".js-view-count[data-work-id=66069658]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069658; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069658']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069658, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069658]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069658,"title":"Labile conjugation of a hydrophilic drug to PLA oligomers to modify a drug delivery system: cephradin in a PLAGA matrix","translated_title":"","metadata":{"abstract":"The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficult because of poor entrapment yield and/or fast release, depending on the microsphere fabrication method. In order to counter the effects of drug hydrophilicity, it is proposed to ...","publisher":"informahealthcare.com","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Journal of …"},"translated_abstract":"The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficult because of poor entrapment yield and/or fast release, depending on the microsphere fabrication method. In order to counter the effects of drug hydrophilicity, it is proposed to ...","internal_url":"https://www.academia.edu/66069658/Labile_conjugation_of_a_hydrophilic_drug_to_PLA_oligomers_to_modify_a_drug_delivery_system_cephradin_in_a_PLAGA_matrix","translated_internal_url":"","created_at":"2021-12-26T23:44:31.926-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Labile_conjugation_of_a_hydrophilic_drug_to_PLA_oligomers_to_modify_a_drug_delivery_system_cephradin_in_a_PLAGA_matrix","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":21466,"name":"Polymers","url":"https://www.academia.edu/Documents/in/Polymers"},{"id":57800,"name":"Microencapsulation","url":"https://www.academia.edu/Documents/in/Microencapsulation"},{"id":83128,"name":"Escherichia coli","url":"https://www.academia.edu/Documents/in/Escherichia_coli"},{"id":116078,"name":"Staphylococcus aureus","url":"https://www.academia.edu/Documents/in/Staphylococcus_aureus"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems"},{"id":995181,"name":"Capsules","url":"https://www.academia.edu/Documents/in/Capsules"},{"id":1074508,"name":"Lactic Acid","url":"https://www.academia.edu/Documents/in/Lactic_Acid"},{"id":1135812,"name":"Drug Compounding","url":"https://www.academia.edu/Documents/in/Drug_Compounding"},{"id":1137107,"name":"Delayed-Action Preparations","url":"https://www.academia.edu/Documents/in/Delayed-Action_Preparations"},{"id":1842148,"name":"Cephradine","url":"https://www.academia.edu/Documents/in/Cephradine"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"},{"id":3881526,"name":"In Vitro Techniques","url":"https://www.academia.edu/Documents/in/In_Vitro_Techniques"}],"urls":[{"id":15723558,"url":"http://direct.bl.uk/research/34/0C/RN083560630.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069657"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069657/Optimized_release_of_dexamethasone_and_gentamicin_from_a_soluble_ocular_insert_for_the_treatment_of_external_ophthalmic_infections"><img alt="Research paper thumbnail of Optimized release of dexamethasone and gentamicin from a soluble ocular insert for the treatment of external ophthalmic infections" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069657/Optimized_release_of_dexamethasone_and_gentamicin_from_a_soluble_ocular_insert_for_the_treatment_of_external_ophthalmic_infections">Optimized release of dexamethasone and gentamicin from a soluble ocular insert for the treatment of external ophthalmic infections</a></div><div class="wp-workCard_item"><span>Journal of controlled …</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the case of external ophthalmic infections, repeated instillations of antibiotics are required...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the case of external ophthalmic infections, repeated instillations of antibiotics are required to reach therapeutic level, above the minimal inhibitory concentration (MIC). An additional administration of a corticosteroid is often needed, in order to limit the precorneal damages caused by the infection. However, repeated administration of a corticosteroid can increase intraocular pressure and thus lead to glaucoma. To overcome the disadvantages of separated and repeated instillations of two products and to avoid the side effects of dexamethasone, a soluble insert containing gentamicin sulfate and dexamethasone phosphate was developed. The new system ensures the concomitant release of the two drugs during the first 10 h of treatment, followed by an adequate concentration of gentamicin sulfate, above the MIC of 4.0 microgram ml-1, during 50 h, due to a combination of gentamicin sulfate with cellulose acetate phthalate, which reduces the solubility of gentamicin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069657"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069657"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069657; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069657]").text(description); $(".js-view-count[data-work-id=66069657]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069657; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069657']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069657, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069657]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069657,"title":"Optimized release of dexamethasone and gentamicin from a soluble ocular insert for the treatment of external ophthalmic infections","translated_title":"","metadata":{"abstract":"In the case of external ophthalmic infections, repeated instillations of antibiotics are required to reach therapeutic level, above the minimal inhibitory concentration (MIC). An additional administration of a corticosteroid is often needed, in order to limit the precorneal damages caused by the infection. However, repeated administration of a corticosteroid can increase intraocular pressure and thus lead to glaucoma. To overcome the disadvantages of separated and repeated instillations of two products and to avoid the side effects of dexamethasone, a soluble insert containing gentamicin sulfate and dexamethasone phosphate was developed. The new system ensures the concomitant release of the two drugs during the first 10 h of treatment, followed by an adequate concentration of gentamicin sulfate, above the MIC of 4.0 microgram ml-1, during 50 h, due to a combination of gentamicin sulfate with cellulose acetate phthalate, which reduces the solubility of gentamicin.","publisher":"Elsevier","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Journal of controlled …"},"translated_abstract":"In the case of external ophthalmic infections, repeated instillations of antibiotics are required to reach therapeutic level, above the minimal inhibitory concentration (MIC). An additional administration of a corticosteroid is often needed, in order to limit the precorneal damages caused by the infection. However, repeated administration of a corticosteroid can increase intraocular pressure and thus lead to glaucoma. To overcome the disadvantages of separated and repeated instillations of two products and to avoid the side effects of dexamethasone, a soluble insert containing gentamicin sulfate and dexamethasone phosphate was developed. The new system ensures the concomitant release of the two drugs during the first 10 h of treatment, followed by an adequate concentration of gentamicin sulfate, above the MIC of 4.0 microgram ml-1, during 50 h, due to a combination of gentamicin sulfate with cellulose acetate phthalate, which reduces the solubility of gentamicin.","internal_url":"https://www.academia.edu/66069657/Optimized_release_of_dexamethasone_and_gentamicin_from_a_soluble_ocular_insert_for_the_treatment_of_external_ophthalmic_infections","translated_internal_url":"","created_at":"2021-12-26T23:44:31.823-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Optimized_release_of_dexamethasone_and_gentamicin_from_a_soluble_ocular_insert_for_the_treatment_of_external_ophthalmic_infections","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":57801,"name":"Dexamethasone","url":"https://www.academia.edu/Documents/in/Dexamethasone"},{"id":64660,"name":"Controlled release","url":"https://www.academia.edu/Documents/in/Controlled_release"},{"id":121320,"name":"Intraocular Pressure","url":"https://www.academia.edu/Documents/in/Intraocular_Pressure"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents"},{"id":698785,"name":"Side Effect","url":"https://www.academia.edu/Documents/in/Side_Effect"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"},{"id":1136003,"name":"Cellulose Acetate","url":"https://www.academia.edu/Documents/in/Cellulose_Acetate"},{"id":2282998,"name":"Insert","url":"https://www.academia.edu/Documents/in/Insert"},{"id":2467505,"name":"Gentamicins","url":"https://www.academia.edu/Documents/in/Gentamicins"},{"id":2764779,"name":"minimal inhibitory concentration","url":"https://www.academia.edu/Documents/in/minimal_inhibitory_concentration"},{"id":3421103,"name":"Eye infections","url":"https://www.academia.edu/Documents/in/Eye_infections"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069656"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069656/Determination_of_a_dosage_regimen_of_colistin_by_pharmacokinetic_pharmacodynamic_integration_and_modeling_for_treatment_of_GIT_disease_in_pigs"><img alt="Research paper thumbnail of Determination of a dosage regimen of colistin by pharmacokinetic/pharmacodynamic integration and modeling for treatment of GIT disease in pigs" class="work-thumbnail" src="https://attachments.academia-assets.com/77406287/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069656/Determination_of_a_dosage_regimen_of_colistin_by_pharmacokinetic_pharmacodynamic_integration_and_modeling_for_treatment_of_GIT_disease_in_pigs">Determination of a dosage regimen of colistin by pharmacokinetic/pharmacodynamic integration and modeling for treatment of GIT disease in pigs</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3047706330a1b0cc611ad5f7259681a1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77406287,"asset_id":66069656,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77406287/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069656"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069656"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069656; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069656]").text(description); $(".js-view-count[data-work-id=66069656]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069656; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069656']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069656, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3047706330a1b0cc611ad5f7259681a1" } } $('.js-work-strip[data-work-id=66069656]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069656,"title":"Determination of a dosage regimen of colistin by pharmacokinetic/pharmacodynamic integration and modeling for treatment of GIT disease in pigs","translated_title":"","metadata":{"grobid_abstract":"Colistin is an antimicrobial drug of the polymyxin group and COLIVET SOLUTION is an aqueous solution containing colistin sulphate (2 Â 10 6 IU/mL), formulated for oral administration. The target species is the pig, particularly the suckling and post weaning animal. This investigation was undertaken to provide pharmacokinetic and pharmacodynamic data on which to base the selection of dosage rate and interval of the solution for the treatment of porcine colibacillosis. Colistin absorption from the gastrointestinal tract of young pigs, when administered at dosage rates of 25,000, 50,000 and 1,00,000 IU/kg, was slight or absent. The drug was therefore restricted almost entirely to the required site of action. The colistin concentration-time profile within the jejunum and ileum was established, and this enabled determination of the pharmacokinetic variables, maximum concentration (C max) and area under curve (AUC) and derivation of the surrogate indices of antibacterial activity, C max /minimum inhibitory concentration (MIC) and AUC/MIC through integration of in vivo data with the results of in vitro potency studies for four strains of Escherichia coli. In the in vitro bacterial growth inhibition studies colistin acted by a concentration-dependent killing mechanism. Numerical values for the surrogate parameter AUC/MIC producing bactericidal and eradication effects of colistin against four strains of E. coli were established by PK-PD modeling based on the sigmoidal E max equation. These data were used to predict a daily dosage regimen for colistin.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"grobid_abstract_attachment_id":77406287},"translated_abstract":null,"internal_url":"https://www.academia.edu/66069656/Determination_of_a_dosage_regimen_of_colistin_by_pharmacokinetic_pharmacodynamic_integration_and_modeling_for_treatment_of_GIT_disease_in_pigs","translated_internal_url":"","created_at":"2021-12-26T23:44:31.711-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":77406287,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406287/thumbnails/1.jpg","file_name":"j.rvsc.2009.09.00120211226-20106-175klfz.pdf","download_url":"https://www.academia.edu/attachments/77406287/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Determination_of_a_dosage_regimen_of_col.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406287/j.rvsc.2009.09.00120211226-20106-175klfz-libre.pdf?1640595264=\u0026response-content-disposition=attachment%3B+filename%3DDetermination_of_a_dosage_regimen_of_col.pdf\u0026Expires=1733024047\u0026Signature=F3HC2jl7SxnX6o1Gzl~GWF6HKkXixZT1prqjcpcDYXrDR-xKenxXBw6PFxIDmUPQAGCpG7t4LYj9GdAsz5VGrL9BfkgIlcjgO6rI3ld-TuTo4MTGmOCNXPqRo7a5PuTethfJixhlB6Qfx0qlSCK-4UUR4u1rGBJ28536dARTw5sgllMkMcTCjX6DinaaZS3t9EW1MaqgcOACuIHec5XzRLYkAxlpoQtKqEsfR~CsYAjkvJq9e7w4UTmcjL7zQ2wLOOCal8wYB103VOp9oVAfqVCC~m-eeaa-yzIOcdyfnBMDD0WUCl0qCzMiyHlxaYg-ldGL7DlXWB2DuTfl~kkFyQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Determination_of_a_dosage_regimen_of_colistin_by_pharmacokinetic_pharmacodynamic_integration_and_modeling_for_treatment_of_GIT_disease_in_pigs","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[{"id":77406287,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406287/thumbnails/1.jpg","file_name":"j.rvsc.2009.09.00120211226-20106-175klfz.pdf","download_url":"https://www.academia.edu/attachments/77406287/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Determination_of_a_dosage_regimen_of_col.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406287/j.rvsc.2009.09.00120211226-20106-175klfz-libre.pdf?1640595264=\u0026response-content-disposition=attachment%3B+filename%3DDetermination_of_a_dosage_regimen_of_col.pdf\u0026Expires=1733024047\u0026Signature=F3HC2jl7SxnX6o1Gzl~GWF6HKkXixZT1prqjcpcDYXrDR-xKenxXBw6PFxIDmUPQAGCpG7t4LYj9GdAsz5VGrL9BfkgIlcjgO6rI3ld-TuTo4MTGmOCNXPqRo7a5PuTethfJixhlB6Qfx0qlSCK-4UUR4u1rGBJ28536dARTw5sgllMkMcTCjX6DinaaZS3t9EW1MaqgcOACuIHec5XzRLYkAxlpoQtKqEsfR~CsYAjkvJq9e7w4UTmcjL7zQ2wLOOCal8wYB103VOp9oVAfqVCC~m-eeaa-yzIOcdyfnBMDD0WUCl0qCzMiyHlxaYg-ldGL7DlXWB2DuTfl~kkFyQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29980,"name":"Animal Production","url":"https://www.academia.edu/Documents/in/Animal_Production"},{"id":43294,"name":"Veterinary Science","url":"https://www.academia.edu/Documents/in/Veterinary_Science"},{"id":83128,"name":"Escherichia coli","url":"https://www.academia.edu/Documents/in/Escherichia_coli"},{"id":290432,"name":"Antibacterial activity","url":"https://www.academia.edu/Documents/in/Antibacterial_activity"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents"},{"id":408997,"name":"Colistin","url":"https://www.academia.edu/Documents/in/Colistin"},{"id":419370,"name":"Swine","url":"https://www.academia.edu/Documents/in/Swine"},{"id":479537,"name":"Bacterial growth","url":"https://www.academia.edu/Documents/in/Bacterial_growth"},{"id":537759,"name":"Gastrointestinal Tract","url":"https://www.academia.edu/Documents/in/Gastrointestinal_Tract"},{"id":561014,"name":"Microbial Sensitivity Tests","url":"https://www.academia.edu/Documents/in/Microbial_Sensitivity_Tests"},{"id":644860,"name":"Veterinary Sciences","url":"https://www.academia.edu/Documents/in/Veterinary_Sciences"},{"id":770580,"name":"Swine Diseases","url":"https://www.academia.edu/Documents/in/Swine_Diseases"},{"id":989646,"name":"Aqueous Solution","url":"https://www.academia.edu/Documents/in/Aqueous_Solution"},{"id":1309706,"name":"Area Under Curve","url":"https://www.academia.edu/Documents/in/Area_Under_Curve"},{"id":1692059,"name":"Minimum inhibitory concentration","url":"https://www.academia.edu/Documents/in/Minimum_inhibitory_concentration"},{"id":2430299,"name":"Gastrointestinal Diseases","url":"https://www.academia.edu/Documents/in/Gastrointestinal_Diseases"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069550"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069550/Salivary_fluoride_concentrations_following_applications_of_bioadhesive_tablets_and_mouthrinses"><img alt="Research paper thumbnail of Salivary fluoride concentrations following applications of bioadhesive tablets and mouthrinses" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069550/Salivary_fluoride_concentrations_following_applications_of_bioadhesive_tablets_and_mouthrinses">Salivary fluoride concentrations following applications of bioadhesive tablets and mouthrinses</a></div><div class="wp-workCard_item"><span>European Journal of Pharmaceutics and Biopharmaceutics</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Presence of elevated fluoride concentration in saliva is important for the prevention of caries. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Presence of elevated fluoride concentration in saliva is important for the prevention of caries. In the present study, we developed an intra-oral bioadhesive tablet aimed at delivering F(-) in the mouth over a prolonged period of time. Various tablet formulations were tested in vivo for their tolerance and adhesiveness. Two formulations were selected for further studies on salivary fluoride clearance. For comparison, mouthrinses with increasing F(-) concentrations were also examined. Results indicate that a bioadhesive tablet located on the upper gingiva is able to sustain salivary F(-) concentrations for about 10h without major side effects. Mouthrinses with high F(-) concentration were able to prolong salivary fluoride retention for more than 6h.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069550"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069550"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069550; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069550]").text(description); $(".js-view-count[data-work-id=66069550]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069550; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069550']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069550, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069550]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069550,"title":"Salivary fluoride concentrations following applications of bioadhesive tablets and mouthrinses","translated_title":"","metadata":{"abstract":"Presence of elevated fluoride concentration in saliva is important for the prevention of caries. In the present study, we developed an intra-oral bioadhesive tablet aimed at delivering F(-) in the mouth over a prolonged period of time. Various tablet formulations were tested in vivo for their tolerance and adhesiveness. Two formulations were selected for further studies on salivary fluoride clearance. For comparison, mouthrinses with increasing F(-) concentrations were also examined. Results indicate that a bioadhesive tablet located on the upper gingiva is able to sustain salivary F(-) concentrations for about 10h without major side effects. Mouthrinses with high F(-) concentration were able to prolong salivary fluoride retention for more than 6h.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"European Journal of Pharmaceutics and Biopharmaceutics"},"translated_abstract":"Presence of elevated fluoride concentration in saliva is important for the prevention of caries. In the present study, we developed an intra-oral bioadhesive tablet aimed at delivering F(-) in the mouth over a prolonged period of time. Various tablet formulations were tested in vivo for their tolerance and adhesiveness. Two formulations were selected for further studies on salivary fluoride clearance. For comparison, mouthrinses with increasing F(-) concentrations were also examined. Results indicate that a bioadhesive tablet located on the upper gingiva is able to sustain salivary F(-) concentrations for about 10h without major side effects. Mouthrinses with high F(-) concentration were able to prolong salivary fluoride retention for more than 6h.","internal_url":"https://www.academia.edu/66069550/Salivary_fluoride_concentrations_following_applications_of_bioadhesive_tablets_and_mouthrinses","translated_internal_url":"","created_at":"2021-12-26T23:43:31.773-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Salivary_fluoride_concentrations_following_applications_of_bioadhesive_tablets_and_mouthrinses","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery"},{"id":105826,"name":"Dental Caries","url":"https://www.academia.edu/Documents/in/Dental_Caries"},{"id":146936,"name":"Fluorides","url":"https://www.academia.edu/Documents/in/Fluorides"},{"id":344106,"name":"Saliva","url":"https://www.academia.edu/Documents/in/Saliva"},{"id":375098,"name":"Gingiva","url":"https://www.academia.edu/Documents/in/Gingiva"},{"id":421276,"name":"Delivery System","url":"https://www.academia.edu/Documents/in/Delivery_System"},{"id":469032,"name":"Mouthwashes","url":"https://www.academia.edu/Documents/in/Mouthwashes"},{"id":469096,"name":"Cariostatic Agents","url":"https://www.academia.edu/Documents/in/Cariostatic_Agents"},{"id":476883,"name":"Tablets","url":"https://www.academia.edu/Documents/in/Tablets"},{"id":687524,"name":"Adhesives","url":"https://www.academia.edu/Documents/in/Adhesives"},{"id":698785,"name":"Side Effect","url":"https://www.academia.edu/Documents/in/Side_Effect"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3788378" id="papers"><div class="js-work-strip profile--work_container" data-work-id="113553300"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113553300/Six_month_target_animal_safety_study_of_spironolactone_and_benazepril_hydrochloride_combination_Cardalis_R_for_oral_administration_in_dogs"><img alt="Research paper thumbnail of Six month target animal safety study of spironolactone and benazepril hydrochloride combination (Cardalis (R)) for oral administration in dogs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113553300/Six_month_target_animal_safety_study_of_spironolactone_and_benazepril_hydrochloride_combination_Cardalis_R_for_oral_administration_in_dogs">Six month target animal safety study of spironolactone and benazepril hydrochloride combination (Cardalis (R)) for oral administration in dogs</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113553300"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113553300"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113553300; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113553300]").text(description); $(".js-view-count[data-work-id=113553300]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113553300; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113553300']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113553300, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=113553300]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113553300,"title":"Six month target animal safety study of spironolactone and benazepril hydrochloride combination (Cardalis (R)) for oral administration in dogs","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2012,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/113553300/Six_month_target_animal_safety_study_of_spironolactone_and_benazepril_hydrochloride_combination_Cardalis_R_for_oral_administration_in_dogs","translated_internal_url":"","created_at":"2024-01-15T14:44:24.751-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Six_month_target_animal_safety_study_of_spironolactone_and_benazepril_hydrochloride_combination_Cardalis_R_for_oral_administration_in_dogs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":3329465,"name":"Spironolactone","url":"https://www.academia.edu/Documents/in/Spironolactone"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103418510"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103418510/Rationale_of_a_Combination_of_Spironolactone_and_Benazepril_for_Treatment_of_Heart_Failure_in_Dog"><img alt="Research paper thumbnail of Rationale of a Combination of Spironolactone and Benazepril for Treatment of Heart Failure in Dog" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103418510/Rationale_of_a_Combination_of_Spironolactone_and_Benazepril_for_Treatment_of_Heart_Failure_in_Dog">Rationale of a Combination of Spironolactone and Benazepril for Treatment of Heart Failure in Dog</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103418510"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103418510"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103418510; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103418510]").text(description); $(".js-view-count[data-work-id=103418510]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103418510; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103418510']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 103418510, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=103418510]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103418510,"title":"Rationale of a Combination of Spironolactone and Benazepril for Treatment of Heart Failure in Dog","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2012,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/103418510/Rationale_of_a_Combination_of_Spironolactone_and_Benazepril_for_Treatment_of_Heart_Failure_in_Dog","translated_internal_url":"","created_at":"2023-06-16T00:00:27.132-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Rationale_of_a_Combination_of_Spironolactone_and_Benazepril_for_Treatment_of_Heart_Failure_in_Dog","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":49633,"name":"Heart Failure","url":"https://www.academia.edu/Documents/in/Heart_Failure"},{"id":3329465,"name":"Spironolactone","url":"https://www.academia.edu/Documents/in/Spironolactone"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="99906279"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/99906279/Bovine_mastitis_and_intramammary_drug_delivery_review_and_perspectives"><img alt="Research paper thumbnail of Bovine mastitis and intramammary drug delivery: review and perspectives" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/99906279/Bovine_mastitis_and_intramammary_drug_delivery_review_and_perspectives">Bovine mastitis and intramammary drug delivery: review and perspectives</a></div><div class="wp-workCard_item"><span>Advanced Drug Delivery Reviews</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Intramammary infections (IMIs) represent a major feature in bovine pathology. The treatment of IM...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Intramammary infections (IMIs) represent a major feature in bovine pathology. The treatment of IMIs concern antimicrobial substances. Therapeutic strategies involve administration of immediate release formulations during lactation with or without long-acting formulations during the dry period. Current treatments are not very successful and cure rates are poor, especially towards Staphylococcus aureus which is responsible for chronic infections and huge economic losses. New strategies have recently been investigated. These include particular immunomodulators like lysostaphin or cytokines, and novel formulations (e.g. liposomes, microparticles or nanoparticles) that allow uptake of the active component by phagocytes and thus prolong an enhanced antibacterial activity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="99906279"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="99906279"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 99906279; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=99906279]").text(description); $(".js-view-count[data-work-id=99906279]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 99906279; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='99906279']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 99906279, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=99906279]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":99906279,"title":"Bovine mastitis and intramammary drug delivery: review and perspectives","translated_title":"","metadata":{"abstract":"Intramammary infections (IMIs) represent a major feature in bovine pathology. The treatment of IMIs concern antimicrobial substances. Therapeutic strategies involve administration of immediate release formulations during lactation with or without long-acting formulations during the dry period. Current treatments are not very successful and cure rates are poor, especially towards Staphylococcus aureus which is responsible for chronic infections and huge economic losses. New strategies have recently been investigated. These include particular immunomodulators like lysostaphin or cytokines, and novel formulations (e.g. liposomes, microparticles or nanoparticles) that allow uptake of the active component by phagocytes and thus prolong an enhanced antibacterial activity.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Advanced Drug Delivery Reviews"},"translated_abstract":"Intramammary infections (IMIs) represent a major feature in bovine pathology. The treatment of IMIs concern antimicrobial substances. Therapeutic strategies involve administration of immediate release formulations during lactation with or without long-acting formulations during the dry period. Current treatments are not very successful and cure rates are poor, especially towards Staphylococcus aureus which is responsible for chronic infections and huge economic losses. New strategies have recently been investigated. These include particular immunomodulators like lysostaphin or cytokines, and novel formulations (e.g. liposomes, microparticles or nanoparticles) that allow uptake of the active component by phagocytes and thus prolong an enhanced antibacterial activity.","internal_url":"https://www.academia.edu/99906279/Bovine_mastitis_and_intramammary_drug_delivery_review_and_perspectives","translated_internal_url":"","created_at":"2023-04-09T02:44:19.063-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Bovine_mastitis_and_intramammary_drug_delivery_review_and_perspectives","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery"},{"id":17008,"name":"Mastitis","url":"https://www.academia.edu/Documents/in/Mastitis"},{"id":17014,"name":"Bovine Mastitis","url":"https://www.academia.edu/Documents/in/Bovine_Mastitis"},{"id":19826,"name":"Lactation","url":"https://www.academia.edu/Documents/in/Lactation"},{"id":23390,"name":"Pharmaceutical Chemistry","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":41747,"name":"Dosage Form","url":"https://www.academia.edu/Documents/in/Dosage_Form"},{"id":64660,"name":"Controlled release","url":"https://www.academia.edu/Documents/in/Controlled_release"},{"id":95522,"name":"Advanced Drug Delivery Research","url":"https://www.academia.edu/Documents/in/Advanced_Drug_Delivery_Research"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems"},{"id":183266,"name":"Liposome","url":"https://www.academia.edu/Documents/in/Liposome"},{"id":220036,"name":"Antimicrobial","url":"https://www.academia.edu/Documents/in/Antimicrobial"},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle"},{"id":290432,"name":"Antibacterial activity","url":"https://www.academia.edu/Documents/in/Antibacterial_activity"},{"id":605367,"name":"Economic Loss","url":"https://www.academia.edu/Documents/in/Economic_Loss"},{"id":2670783,"name":"Chronic Infection","url":"https://www.academia.edu/Documents/in/Chronic_Infection"},{"id":3779594,"name":"dry period","url":"https://www.academia.edu/Documents/in/dry_period"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"},{"id":4042244,"name":"Lysostaphin","url":"https://www.academia.edu/Documents/in/Lysostaphin"}],"urls":[{"id":30482495,"url":"https://api.elsevier.com/content/article/PII:S0169409X01001600?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90609143"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90609143/Clinical_evaluation_of_bioadhesive_ophthalmic_drug_inserts_BODI_for_the_treatment_of_external_ocular_infections_in_dogs"><img alt="Research paper thumbnail of Clinical evaluation of bioadhesive ophthalmic drug inserts (BODI®) for the treatment of external ocular infections in dogs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90609143/Clinical_evaluation_of_bioadhesive_ophthalmic_drug_inserts_BODI_for_the_treatment_of_external_ocular_infections_in_dogs">Clinical evaluation of bioadhesive ophthalmic drug inserts (BODI®) for the treatment of external ocular infections in dogs</a></div><div class="wp-workCard_item"><span>Journal of Controlled Release</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the case of external ocular diseases such as conjunctivitis, keratoconjunctivitis sicca (KCS) ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the case of external ocular diseases such as conjunctivitis, keratoconjunctivitis sicca (KCS) and superficial corneal ulcers, topical administration of eyedrops containing an antibacterial agent is often prescribed. Numerous daily instillations of eyedrops over several days are required for successful treatment, often leading to bad compliance. In addition, the reflex lachrymation following instillation promotes rapid elimination of the drug from the corneal surface. To overcome the disadvantage of repeated instillations, a soluble bioadhesive ophthalmic drug insert (BODI) to be placed in the lower cul de sac of the eye was developed. The clinical efficacy, after deposition of one insert and a classical eyedrop treatment (Tiacil), Virbac Laboratories), was investigated in dogs presenting conjunctivitis, superficial corneal ulcer or keratoconjunctivitis sicca (KCS). Similar total clinical recovery results were obtained after 3 and 7 days for both treatments. BODI can therefore advantageously be prescribed for the treatment of external ophthalmic diseases, by reducing the treatment to a single application and therefore improving compliance compared to classical eyedrop treatment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90609143"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90609143"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90609143; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90609143]").text(description); $(".js-view-count[data-work-id=90609143]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90609143; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90609143']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90609143, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90609143]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90609143,"title":"Clinical evaluation of bioadhesive ophthalmic drug inserts (BODI®) for the treatment of external ocular infections in dogs","translated_title":"","metadata":{"abstract":"In the case of external ocular diseases such as conjunctivitis, keratoconjunctivitis sicca (KCS) and superficial corneal ulcers, topical administration of eyedrops containing an antibacterial agent is often prescribed. Numerous daily instillations of eyedrops over several days are required for successful treatment, often leading to bad compliance. In addition, the reflex lachrymation following instillation promotes rapid elimination of the drug from the corneal surface. To overcome the disadvantage of repeated instillations, a soluble bioadhesive ophthalmic drug insert (BODI) to be placed in the lower cul de sac of the eye was developed. The clinical efficacy, after deposition of one insert and a classical eyedrop treatment (Tiacil), Virbac Laboratories), was investigated in dogs presenting conjunctivitis, superficial corneal ulcer or keratoconjunctivitis sicca (KCS). Similar total clinical recovery results were obtained after 3 and 7 days for both treatments. BODI can therefore advantageously be prescribed for the treatment of external ophthalmic diseases, by reducing the treatment to a single application and therefore improving compliance compared to classical eyedrop treatment.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Journal of Controlled Release"},"translated_abstract":"In the case of external ocular diseases such as conjunctivitis, keratoconjunctivitis sicca (KCS) and superficial corneal ulcers, topical administration of eyedrops containing an antibacterial agent is often prescribed. Numerous daily instillations of eyedrops over several days are required for successful treatment, often leading to bad compliance. In addition, the reflex lachrymation following instillation promotes rapid elimination of the drug from the corneal surface. To overcome the disadvantage of repeated instillations, a soluble bioadhesive ophthalmic drug insert (BODI) to be placed in the lower cul de sac of the eye was developed. The clinical efficacy, after deposition of one insert and a classical eyedrop treatment (Tiacil), Virbac Laboratories), was investigated in dogs presenting conjunctivitis, superficial corneal ulcer or keratoconjunctivitis sicca (KCS). Similar total clinical recovery results were obtained after 3 and 7 days for both treatments. BODI can therefore advantageously be prescribed for the treatment of external ophthalmic diseases, by reducing the treatment to a single application and therefore improving compliance compared to classical eyedrop treatment.","internal_url":"https://www.academia.edu/90609143/Clinical_evaluation_of_bioadhesive_ophthalmic_drug_inserts_BODI_for_the_treatment_of_external_ocular_infections_in_dogs","translated_internal_url":"","created_at":"2022-11-12T11:15:26.521-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Clinical_evaluation_of_bioadhesive_ophthalmic_drug_inserts_BODI_for_the_treatment_of_external_ocular_infections_in_dogs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery"},{"id":17721,"name":"Cornea","url":"https://www.academia.edu/Documents/in/Cornea"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":64660,"name":"Controlled release","url":"https://www.academia.edu/Documents/in/Controlled_release"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems"},{"id":245634,"name":"Eye","url":"https://www.academia.edu/Documents/in/Eye"},{"id":687524,"name":"Adhesives","url":"https://www.academia.edu/Documents/in/Adhesives"},{"id":702103,"name":"Antibacterial Agent","url":"https://www.academia.edu/Documents/in/Antibacterial_Agent"},{"id":1137112,"name":"Ophthalmic Solutions","url":"https://www.academia.edu/Documents/in/Ophthalmic_Solutions"},{"id":1174994,"name":"Bacterial Infection","url":"https://www.academia.edu/Documents/in/Bacterial_Infection"},{"id":1666741,"name":"Clinical evaluation","url":"https://www.academia.edu/Documents/in/Clinical_evaluation"},{"id":2793624,"name":"keratoconjunctivitis sicca","url":"https://www.academia.edu/Documents/in/keratoconjunctivitis_sicca"},{"id":3505901,"name":"vernal keratoconjunctivitis","url":"https://www.academia.edu/Documents/in/vernal_keratoconjunctivitis"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":25877818,"url":"https://api.elsevier.com/content/article/PII:S0168-3659(02)00284-5?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90609111"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90609111/Keeping_the_drug_in_your_eye"><img alt="Research paper thumbnail of Keeping the drug in your eye" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90609111/Keeping_the_drug_in_your_eye">Keeping the drug in your eye</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90609111"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90609111"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90609111; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90609111]").text(description); $(".js-view-count[data-work-id=90609111]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90609111; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90609111']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 90609111, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90609111]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90609111,"title":"Keeping the drug in your eye","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1995,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/90609111/Keeping_the_drug_in_your_eye","translated_internal_url":"","created_at":"2022-11-12T11:15:00.475-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Keeping_the_drug_in_your_eye","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":42135,"name":"Drug","url":"https://www.academia.edu/Documents/in/Drug"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069671"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069671/Bioequivalence_study_of_two_long_acting_formulations_of_oxytetracycline_following_intramuscular_administration_in_the_sheep"><img alt="Research paper thumbnail of Bioequivalence study of two long-acting formulations of oxytetracycline following intramuscular administration in the sheep" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069671/Bioequivalence_study_of_two_long_acting_formulations_of_oxytetracycline_following_intramuscular_administration_in_the_sheep">Bioequivalence study of two long-acting formulations of oxytetracycline following intramuscular administration in the sheep</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069671"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069671"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069671; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069671]").text(description); $(".js-view-count[data-work-id=66069671]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069671; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069671']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069671, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069671]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069671,"title":"Bioequivalence study of two long-acting formulations of oxytetracycline following intramuscular administration in the sheep","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2000,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/66069671/Bioequivalence_study_of_two_long_acting_formulations_of_oxytetracycline_following_intramuscular_administration_in_the_sheep","translated_internal_url":"","created_at":"2021-12-26T23:44:33.413-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Bioequivalence_study_of_two_long_acting_formulations_of_oxytetracycline_following_intramuscular_administration_in_the_sheep","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069670"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069670/Specifications_for_the_design_of_dosage_forms_Report_of_an_SFSTP_commission"><img alt="Research paper thumbnail of Specifications for the design of dosage forms : Report of an SFSTP commission" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069670/Specifications_for_the_design_of_dosage_forms_Report_of_an_SFSTP_commission">Specifications for the design of dosage forms : Report of an SFSTP commission</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The need to elaborate specifications for the development of new dosage forms appears as a prerequ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The need to elaborate specifications for the development of new dosage forms appears as a prerequisite to quality control. This document must be presented as a contract between the different persons involved in the project and be capable of evolving during the different development phases. It must enable the formulation scientist to clearly define the objectives and key points of the new dosage form development. Early data necessary to elaborate these specifications are of scientific, economic, commercial, industrial, regulatory and environmental natures. Dans le cadre du developpement d&#39;une nouvelle forme pharmaceutique, l&#39;elaboration d&#39;un cahier des charges galenique apparait comme une necessite dans la maitrise de la qualite. Ce document doit etre contractuel, refletant les points de vue des differents acteurs du developpement, et evolutif en s&#39;adaptant aux differentes phases de mise au point. Il doit permettre aux galenistes de mieux definir les objectifs et les ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069670"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069670"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069670; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069670]").text(description); $(".js-view-count[data-work-id=66069670]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069670; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069670']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069670, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069670]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069670,"title":"Specifications for the design of dosage forms : Report of an SFSTP commission","translated_title":"","metadata":{"abstract":"The need to elaborate specifications for the development of new dosage forms appears as a prerequisite to quality control. This document must be presented as a contract between the different persons involved in the project and be capable of evolving during the different development phases. It must enable the formulation scientist to clearly define the objectives and key points of the new dosage form development. Early data necessary to elaborate these specifications are of scientific, economic, commercial, industrial, regulatory and environmental natures. Dans le cadre du developpement d\u0026#39;une nouvelle forme pharmaceutique, l\u0026#39;elaboration d\u0026#39;un cahier des charges galenique apparait comme une necessite dans la maitrise de la qualite. Ce document doit etre contractuel, refletant les points de vue des differents acteurs du developpement, et evolutif en s\u0026#39;adaptant aux differentes phases de mise au point. Il doit permettre aux galenistes de mieux definir les objectifs et les ...","publication_date":{"day":null,"month":null,"year":1996,"errors":{}}},"translated_abstract":"The need to elaborate specifications for the development of new dosage forms appears as a prerequisite to quality control. This document must be presented as a contract between the different persons involved in the project and be capable of evolving during the different development phases. It must enable the formulation scientist to clearly define the objectives and key points of the new dosage form development. Early data necessary to elaborate these specifications are of scientific, economic, commercial, industrial, regulatory and environmental natures. Dans le cadre du developpement d\u0026#39;une nouvelle forme pharmaceutique, l\u0026#39;elaboration d\u0026#39;un cahier des charges galenique apparait comme une necessite dans la maitrise de la qualite. Ce document doit etre contractuel, refletant les points de vue des differents acteurs du developpement, et evolutif en s\u0026#39;adaptant aux differentes phases de mise au point. Il doit permettre aux galenistes de mieux definir les objectifs et les ...","internal_url":"https://www.academia.edu/66069670/Specifications_for_the_design_of_dosage_forms_Report_of_an_SFSTP_commission","translated_internal_url":"","created_at":"2021-12-26T23:44:33.311-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Specifications_for_the_design_of_dosage_forms_Report_of_an_SFSTP_commission","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069669"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069669/Cahier_des_charges_en_conception_gal%C3%A9nique_Rapport_dune_commission_SFSTP"><img alt="Research paper thumbnail of Cahier des charges en conception galénique. Rapport d'une commission SFSTP" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069669/Cahier_des_charges_en_conception_gal%C3%A9nique_Rapport_dune_commission_SFSTP">Cahier des charges en conception galénique. Rapport d'une commission SFSTP</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dans le cadre du developpement d&#39;une nouvelle forme pharmaceutique, l&#39;elaboration d&#39;u...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dans le cadre du developpement d&#39;une nouvelle forme pharmaceutique, l&#39;elaboration d&#39;un cahier des charges galenique apparait comme une necessite dans la maitrise de la qualite. Ce document doit etre contractuel, refletant les points de vue des differents acteurs du developpement, et evolutif, en s&#39;adaptant aux differentes phases de mise au point. Il doit permettre aux galenistes de mieux definir les objectifs et les points clefs du developpement de la nouvelle forme pharmaceutique. Les donnees d&#39;entree pour l&#39;etablissement de ce cahier des charges doivent etre scientifiques, economiques, commerciales, industrielles, technico-reglementaires et environnementales. The need to elaborate specifications for the development of new dosage forms appears as a prerequisite to quality control. This document must be presented as a contract between the different persons involved in the project and be capable of evolving during the different development phases. It must enab...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069669"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069669"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069669; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069669]").text(description); $(".js-view-count[data-work-id=66069669]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069669; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069669']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069669, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069669]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069669,"title":"Cahier des charges en conception galénique. Rapport d'une commission SFSTP","translated_title":"","metadata":{"abstract":"Dans le cadre du developpement d\u0026#39;une nouvelle forme pharmaceutique, l\u0026#39;elaboration d\u0026#39;un cahier des charges galenique apparait comme une necessite dans la maitrise de la qualite. Ce document doit etre contractuel, refletant les points de vue des differents acteurs du developpement, et evolutif, en s\u0026#39;adaptant aux differentes phases de mise au point. Il doit permettre aux galenistes de mieux definir les objectifs et les points clefs du developpement de la nouvelle forme pharmaceutique. Les donnees d\u0026#39;entree pour l\u0026#39;etablissement de ce cahier des charges doivent etre scientifiques, economiques, commerciales, industrielles, technico-reglementaires et environnementales. The need to elaborate specifications for the development of new dosage forms appears as a prerequisite to quality control. This document must be presented as a contract between the different persons involved in the project and be capable of evolving during the different development phases. It must enab...","publication_date":{"day":null,"month":null,"year":1996,"errors":{}}},"translated_abstract":"Dans le cadre du developpement d\u0026#39;une nouvelle forme pharmaceutique, l\u0026#39;elaboration d\u0026#39;un cahier des charges galenique apparait comme une necessite dans la maitrise de la qualite. Ce document doit etre contractuel, refletant les points de vue des differents acteurs du developpement, et evolutif, en s\u0026#39;adaptant aux differentes phases de mise au point. Il doit permettre aux galenistes de mieux definir les objectifs et les points clefs du developpement de la nouvelle forme pharmaceutique. Les donnees d\u0026#39;entree pour l\u0026#39;etablissement de ce cahier des charges doivent etre scientifiques, economiques, commerciales, industrielles, technico-reglementaires et environnementales. The need to elaborate specifications for the development of new dosage forms appears as a prerequisite to quality control. This document must be presented as a contract between the different persons involved in the project and be capable of evolving during the different development phases. It must enab...","internal_url":"https://www.academia.edu/66069669/Cahier_des_charges_en_conception_gal%C3%A9nique_Rapport_dune_commission_SFSTP","translated_internal_url":"","created_at":"2021-12-26T23:44:33.189-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Cahier_des_charges_en_conception_galénique_Rapport_dune_commission_SFSTP","translated_slug":"","page_count":null,"language":"fr","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069668"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069668/The_efficacy_of_an_oral_treatment_with_paromomycin_against_an_experimental_infection_with_Giardia_in_calves"><img alt="Research paper thumbnail of The efficacy of an oral treatment with paromomycin against an experimental infection with Giardia in calves" class="work-thumbnail" src="https://attachments.academia-assets.com/77406319/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069668/The_efficacy_of_an_oral_treatment_with_paromomycin_against_an_experimental_infection_with_Giardia_in_calves">The efficacy of an oral treatment with paromomycin against an experimental infection with Giardia in calves</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7bd60b3bf450890db5fbf73b0fafed76" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77406319,"asset_id":66069668,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77406319/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069668"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069668"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069668; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069668]").text(description); $(".js-view-count[data-work-id=66069668]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069668; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069668']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069668, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7bd60b3bf450890db5fbf73b0fafed76" } } $('.js-work-strip[data-work-id=66069668]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069668,"title":"The efficacy of an oral treatment with paromomycin against an experimental infection with Giardia in calves","translated_title":"","metadata":{"ai_title_tag":"Paromomycin Treatment Efficacy Against Giardia in Calves","grobid_abstract":"A controlled and blinded study was conducted to evaluate the efficacy and safety of a treatment with paromomycin sulphate against an experimental Giardia infection in calves. Animals were infected with 10 5 Giardia cysts of cattle origin and were either treated 11 days later with 25, 50 or 75 mg paromomycin/(kg body weight per day) during 5 consecutive days or not treated (control group). Efficacy was evaluated based on reduction in cyst excretion. Furthermore weight gain and diarrhea scores were monitored. In the group treated with 75 mg/kg per day there was a 100% reduction in cyst excretion until 9 days after the start of the treatment (D9) and a very high reduction (!98%) until D13. There was a high reduction (!93%) until D9 and D13 in the groups treated with 25 and 50 mg/kg, respectively. The cumulative cyst excretion on D13 was significantly (P \u003c 0.05) lower in the groups treated with 75 and 50 mg/kg compared to the control group. Although there was a trend towards higher weight gain and less diarrhea in the treated groups, differences between groups were not significant. No adverse reactions to the paromomycin treatment were recorded. Furthermore, the need for reliable parameters for evaluation of treatments against protozoal infections is emphasised.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"grobid_abstract_attachment_id":77406319},"translated_abstract":null,"internal_url":"https://www.academia.edu/66069668/The_efficacy_of_an_oral_treatment_with_paromomycin_against_an_experimental_infection_with_Giardia_in_calves","translated_internal_url":"","created_at":"2021-12-26T23:44:33.065-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":77406319,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406319/thumbnails/1.jpg","file_name":"j.vetpar.2005.09.00620211226-1060-spgyha.pdf","download_url":"https://www.academia.edu/attachments/77406319/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_efficacy_of_an_oral_treatment_with_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406319/j.vetpar.2005.09.00620211226-1060-spgyha-libre.pdf?1640595262=\u0026response-content-disposition=attachment%3B+filename%3DThe_efficacy_of_an_oral_treatment_with_p.pdf\u0026Expires=1733024046\u0026Signature=NCNasItdq41LtGN8-7A65pXwIaj~2XddDfJ1dhtBL9IPdqas6gewJnTA-QCR60kEVrSKdTt0QqYU0faawbWXMK9vaOeNK1TqruBUApBjBBwK4Cjg7DnP~cjQCUA030fAII7PE42-Qdu9h8NbuGY8QsnYABZIEvcM4JIeK-~kOt4YwyqDcqAvYCC1R51U6-V03KA~khv5WOnN6pocwI~u7DWpgDqWxJ-xmkpN8I~xF12L1MtZGvMp8ahT0HUXPucSP1zdwmkyBIVlkoAW0YsCKRLnsfEUpPiQVYjWoBoCKsoROm7SU6X6lU17E1JS~2QeqV8ti6PVrCXtIBwZGugsow__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_efficacy_of_an_oral_treatment_with_paromomycin_against_an_experimental_infection_with_Giardia_in_calves","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[{"id":77406319,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406319/thumbnails/1.jpg","file_name":"j.vetpar.2005.09.00620211226-1060-spgyha.pdf","download_url":"https://www.academia.edu/attachments/77406319/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_efficacy_of_an_oral_treatment_with_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406319/j.vetpar.2005.09.00620211226-1060-spgyha-libre.pdf?1640595262=\u0026response-content-disposition=attachment%3B+filename%3DThe_efficacy_of_an_oral_treatment_with_p.pdf\u0026Expires=1733024046\u0026Signature=NCNasItdq41LtGN8-7A65pXwIaj~2XddDfJ1dhtBL9IPdqas6gewJnTA-QCR60kEVrSKdTt0QqYU0faawbWXMK9vaOeNK1TqruBUApBjBBwK4Cjg7DnP~cjQCUA030fAII7PE42-Qdu9h8NbuGY8QsnYABZIEvcM4JIeK-~kOt4YwyqDcqAvYCC1R51U6-V03KA~khv5WOnN6pocwI~u7DWpgDqWxJ-xmkpN8I~xF12L1MtZGvMp8ahT0HUXPucSP1zdwmkyBIVlkoAW0YsCKRLnsfEUpPiQVYjWoBoCKsoROm7SU6X6lU17E1JS~2QeqV8ti6PVrCXtIBwZGugsow__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":44259,"name":"Diarrhea","url":"https://www.academia.edu/Documents/in/Diarrhea"},{"id":50634,"name":"Veterinary Parasitology","url":"https://www.academia.edu/Documents/in/Veterinary_Parasitology"},{"id":170652,"name":"Fisheries Sciences","url":"https://www.academia.edu/Documents/in/Fisheries_Sciences"},{"id":218462,"name":"Giardiasis","url":"https://www.academia.edu/Documents/in/Giardiasis"},{"id":238630,"name":"Experimental Infection","url":"https://www.academia.edu/Documents/in/Experimental_Infection"},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle"},{"id":469102,"name":"Feces","url":"https://www.academia.edu/Documents/in/Feces"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight"},{"id":1476273,"name":"Giardia","url":"https://www.academia.edu/Documents/in/Giardia"},{"id":1631043,"name":"Control Group","url":"https://www.academia.edu/Documents/in/Control_Group"},{"id":1993786,"name":"Cumulant","url":"https://www.academia.edu/Documents/in/Cumulant"},{"id":2463495,"name":"Random Allocation","url":"https://www.academia.edu/Documents/in/Random_Allocation"},{"id":3049943,"name":"treatment efficacy","url":"https://www.academia.edu/Documents/in/treatment_efficacy"},{"id":3562462,"name":"cattle diseases","url":"https://www.academia.edu/Documents/in/cattle_diseases"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069667"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069667/Efficacy_of_permethrin_dinotefuran_and_pyriproxyfen_on_adult_fleas_flea_eggs_collection_and_flea_egg_development_following_transplantation_of_mature_female_fleas_Ctenocephalides_felis_felis_from_cats_to_dogs"><img alt="Research paper thumbnail of Efficacy of permethrin, dinotefuran and pyriproxyfen on adult fleas, flea eggs collection, and flea egg development following transplantation of mature female fleas (Ctenocephalides felis felis) from cats to dogs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069667/Efficacy_of_permethrin_dinotefuran_and_pyriproxyfen_on_adult_fleas_flea_eggs_collection_and_flea_egg_development_following_transplantation_of_mature_female_fleas_Ctenocephalides_felis_felis_from_cats_to_dogs">Efficacy of permethrin, dinotefuran and pyriproxyfen on adult fleas, flea eggs collection, and flea egg development following transplantation of mature female fleas (Ctenocephalides felis felis) from cats to dogs</a></div><div class="wp-workCard_item"><span>Veterinary Parasitology</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A novel spot-on formulation combining permethrin, pyriproxifen and dinotefuran (Vectra 3D™ spot-o...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A novel spot-on formulation combining permethrin, pyriproxifen and dinotefuran (Vectra 3D™ spot-on solution for dogs) was evaluated in adult Beagle dogs in a study to determine adulticidal efficacy, egg laying inhibition and viability of Ctenocephalides felis felis eggs (development and emergence of fleas from the collected eggs). Prior to treatment sixteen dogs were checked for their ability to keep fleas 24 hours after infestation and were allocated to treatment groups: 8 dogs served as untreated controls, and 8 dogs were treated once with the tested formulation. The spot on was administered respecting the laboratory recommendations at a dosage of 65-126 mg/kg of permethrin; 8.9-17.4 mg/kg of dinotefuran and 0.8-1.5mg/kg of pyriproxyfen. Each dog was infested with 100 adult cat fleas ready to lay eggs after 72 hours spent feeding on cats. Dogs were infested 24 hours after treatment and then weekly during 63 days. Eggs were collected and counted 24 hours after each infestation and dogs were combed 48 hours after each infestation. Fleas were counted and removed. Collected eggs were placed in incubator to study their development in larvae and into newly emerged adults. A single treatment provided 99.7% adulticidal efficacy on fleas within 48 hours after treatment and controlled re-infestations for up to 30 days (efficacy &amp;gt;96.20%, p&amp;lt;0.05). The egg laying inhibition was over 92.3% for up to 29 days (p&amp;lt;0.05). The adult emergence inhibition remained 100% during 8 weeks after treatment and was 99.8% nine weeks after treatment (p&amp;lt;0.001).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069667"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069667"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069667; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069667]").text(description); $(".js-view-count[data-work-id=66069667]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069667; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069667']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069667, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069667]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069667,"title":"Efficacy of permethrin, dinotefuran and pyriproxyfen on adult fleas, flea eggs collection, and flea egg development following transplantation of mature female fleas (Ctenocephalides felis felis) from cats to dogs","translated_title":"","metadata":{"abstract":"A novel spot-on formulation combining permethrin, pyriproxifen and dinotefuran (Vectra 3D™ spot-on solution for dogs) was evaluated in adult Beagle dogs in a study to determine adulticidal efficacy, egg laying inhibition and viability of Ctenocephalides felis felis eggs (development and emergence of fleas from the collected eggs). Prior to treatment sixteen dogs were checked for their ability to keep fleas 24 hours after infestation and were allocated to treatment groups: 8 dogs served as untreated controls, and 8 dogs were treated once with the tested formulation. The spot on was administered respecting the laboratory recommendations at a dosage of 65-126 mg/kg of permethrin; 8.9-17.4 mg/kg of dinotefuran and 0.8-1.5mg/kg of pyriproxyfen. Each dog was infested with 100 adult cat fleas ready to lay eggs after 72 hours spent feeding on cats. Dogs were infested 24 hours after treatment and then weekly during 63 days. Eggs were collected and counted 24 hours after each infestation and dogs were combed 48 hours after each infestation. Fleas were counted and removed. Collected eggs were placed in incubator to study their development in larvae and into newly emerged adults. A single treatment provided 99.7% adulticidal efficacy on fleas within 48 hours after treatment and controlled re-infestations for up to 30 days (efficacy \u0026amp;gt;96.20%, p\u0026amp;lt;0.05). The egg laying inhibition was over 92.3% for up to 29 days (p\u0026amp;lt;0.05). The adult emergence inhibition remained 100% during 8 weeks after treatment and was 99.8% nine weeks after treatment (p\u0026amp;lt;0.001).","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Veterinary Parasitology"},"translated_abstract":"A novel spot-on formulation combining permethrin, pyriproxifen and dinotefuran (Vectra 3D™ spot-on solution for dogs) was evaluated in adult Beagle dogs in a study to determine adulticidal efficacy, egg laying inhibition and viability of Ctenocephalides felis felis eggs (development and emergence of fleas from the collected eggs). Prior to treatment sixteen dogs were checked for their ability to keep fleas 24 hours after infestation and were allocated to treatment groups: 8 dogs served as untreated controls, and 8 dogs were treated once with the tested formulation. The spot on was administered respecting the laboratory recommendations at a dosage of 65-126 mg/kg of permethrin; 8.9-17.4 mg/kg of dinotefuran and 0.8-1.5mg/kg of pyriproxyfen. Each dog was infested with 100 adult cat fleas ready to lay eggs after 72 hours spent feeding on cats. Dogs were infested 24 hours after treatment and then weekly during 63 days. Eggs were collected and counted 24 hours after each infestation and dogs were combed 48 hours after each infestation. Fleas were counted and removed. Collected eggs were placed in incubator to study their development in larvae and into newly emerged adults. A single treatment provided 99.7% adulticidal efficacy on fleas within 48 hours after treatment and controlled re-infestations for up to 30 days (efficacy \u0026amp;gt;96.20%, p\u0026amp;lt;0.05). The egg laying inhibition was over 92.3% for up to 29 days (p\u0026amp;lt;0.05). The adult emergence inhibition remained 100% during 8 weeks after treatment and was 99.8% nine weeks after treatment (p\u0026amp;lt;0.001).","internal_url":"https://www.academia.edu/66069667/Efficacy_of_permethrin_dinotefuran_and_pyriproxyfen_on_adult_fleas_flea_eggs_collection_and_flea_egg_development_following_transplantation_of_mature_female_fleas_Ctenocephalides_felis_felis_from_cats_to_dogs","translated_internal_url":"","created_at":"2021-12-26T23:44:32.950-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Efficacy_of_permethrin_dinotefuran_and_pyriproxyfen_on_adult_fleas_flea_eggs_collection_and_flea_egg_development_following_transplantation_of_mature_female_fleas_Ctenocephalides_felis_felis_from_cats_to_dogs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":10062,"name":"Siphonaptera","url":"https://www.academia.edu/Documents/in/Siphonaptera"},{"id":41088,"name":"Cats","url":"https://www.academia.edu/Documents/in/Cats"},{"id":50634,"name":"Veterinary Parasitology","url":"https://www.academia.edu/Documents/in/Veterinary_Parasitology"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":52972,"name":"Insecticides","url":"https://www.academia.edu/Documents/in/Insecticides"},{"id":98942,"name":"Ovulation","url":"https://www.academia.edu/Documents/in/Ovulation"},{"id":170652,"name":"Fisheries Sciences","url":"https://www.academia.edu/Documents/in/Fisheries_Sciences"},{"id":490260,"name":"Pyridines","url":"https://www.academia.edu/Documents/in/Pyridines"},{"id":644860,"name":"Veterinary Sciences","url":"https://www.academia.edu/Documents/in/Veterinary_Sciences"},{"id":801416,"name":"Guanidines","url":"https://www.academia.edu/Documents/in/Guanidines"},{"id":3002174,"name":"Permethrin","url":"https://www.academia.edu/Documents/in/Permethrin"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069665"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069665/Ocular_Availability_of_Gentamicin_in_Small_Animals_After_Topical_Administration_of_a_Conventional_Eye_Drop_Solution_and_a_Novel_Long_Acting_Bioadhesive_Ophthalmic_Drug_Insert"><img alt="Research paper thumbnail of Ocular Availability of Gentamicin in Small Animals After Topical Administration of a Conventional Eye Drop Solution and a Novel Long Acting Bioadhesive Ophthalmic Drug Insert" class="work-thumbnail" src="https://attachments.academia-assets.com/77406282/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069665/Ocular_Availability_of_Gentamicin_in_Small_Animals_After_Topical_Administration_of_a_Conventional_Eye_Drop_Solution_and_a_Novel_Long_Acting_Bioadhesive_Ophthalmic_Drug_Insert">Ocular Availability of Gentamicin in Small Animals After Topical Administration of a Conventional Eye Drop Solution and a Novel Long Acting Bioadhesive Ophthalmic Drug Insert</a></div><div class="wp-workCard_item"><span>Pharmaceutical Research</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose. Gentamicin eye drop solutions have a short precorneal residence time. The present study ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose. Gentamicin eye drop solutions have a short precorneal residence time. The present study investigates the effect of gentamicin using a new long acting delivery Bioadhesive Ophthalmic Insert (BODI) in healthy dogs and rabbits and compares the results with a conventional regimen using an eye drop solution.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ff94f9c1f1e2cc52beb69e70fe1ca333" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77406282,"asset_id":66069665,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77406282/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069665"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069665"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069665; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069665]").text(description); $(".js-view-count[data-work-id=66069665]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069665; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069665']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069665, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ff94f9c1f1e2cc52beb69e70fe1ca333" } } $('.js-work-strip[data-work-id=66069665]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069665,"title":"Ocular Availability of Gentamicin in Small Animals After Topical Administration of a Conventional Eye Drop Solution and a Novel Long Acting Bioadhesive Ophthalmic Drug Insert","translated_title":"","metadata":{"abstract":"Purpose. Gentamicin eye drop solutions have a short precorneal residence time. The present study investigates the effect of gentamicin using a new long acting delivery Bioadhesive Ophthalmic Insert (BODI) in healthy dogs and rabbits and compares the results with a conventional regimen using an eye drop solution.","publication_date":{"day":null,"month":null,"year":1995,"errors":{}},"publication_name":"Pharmaceutical Research"},"translated_abstract":"Purpose. Gentamicin eye drop solutions have a short precorneal residence time. The present study investigates the effect of gentamicin using a new long acting delivery Bioadhesive Ophthalmic Insert (BODI) in healthy dogs and rabbits and compares the results with a conventional regimen using an eye drop solution.","internal_url":"https://www.academia.edu/66069665/Ocular_Availability_of_Gentamicin_in_Small_Animals_After_Topical_Administration_of_a_Conventional_Eye_Drop_Solution_and_a_Novel_Long_Acting_Bioadhesive_Ophthalmic_Drug_Insert","translated_internal_url":"","created_at":"2021-12-26T23:44:32.770-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":77406282,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406282/thumbnails/1.jpg","file_name":"a_3A101624252822220211226-20106-zr2k4o.pdf","download_url":"https://www.academia.edu/attachments/77406282/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Ocular_Availability_of_Gentamicin_in_Sma.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406282/a_3A101624252822220211226-20106-zr2k4o-libre.pdf?1640595264=\u0026response-content-disposition=attachment%3B+filename%3DOcular_Availability_of_Gentamicin_in_Sma.pdf\u0026Expires=1733024046\u0026Signature=PMLH6i0Bin9Pf32r~kzGIi95i9jcCG4hVLp0MVS72jn9hJPWLQdH14AgK3JARVKy9tUlNN-CLh4is569G0Fdp-C1VGAwDyoc9jphR8rWy10vXMkyqMMPNb-szXWv21xAk5eO0SNZWq9t-3VJ1UDqXHp0ES46adRUw-raBtt9i9dQ70I66OOX1l2b4rdWRIi0Hl~tScqNAmQj-GuM71TPeM3xjxZJ30gtfeBCukwd9Yo5novSHF5t5AT9Br6hk5jkCNta700ILwMNj5fi7oUX2rp3D-Rjeuk9Nt0X6Op-9WfIMUsORbJvIPa4Nanu6Ww1VzvyKCMtkPlFOZsK1vfGSw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Ocular_Availability_of_Gentamicin_in_Small_Animals_After_Topical_Administration_of_a_Conventional_Eye_Drop_Solution_and_a_Novel_Long_Acting_Bioadhesive_Ophthalmic_Drug_Insert","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[{"id":77406282,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406282/thumbnails/1.jpg","file_name":"a_3A101624252822220211226-20106-zr2k4o.pdf","download_url":"https://www.academia.edu/attachments/77406282/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Ocular_Availability_of_Gentamicin_in_Sma.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406282/a_3A101624252822220211226-20106-zr2k4o-libre.pdf?1640595264=\u0026response-content-disposition=attachment%3B+filename%3DOcular_Availability_of_Gentamicin_in_Sma.pdf\u0026Expires=1733024046\u0026Signature=PMLH6i0Bin9Pf32r~kzGIi95i9jcCG4hVLp0MVS72jn9hJPWLQdH14AgK3JARVKy9tUlNN-CLh4is569G0Fdp-C1VGAwDyoc9jphR8rWy10vXMkyqMMPNb-szXWv21xAk5eO0SNZWq9t-3VJ1UDqXHp0ES46adRUw-raBtt9i9dQ70I66OOX1l2b4rdWRIi0Hl~tScqNAmQj-GuM71TPeM3xjxZJ30gtfeBCukwd9Yo5novSHF5t5AT9Br6hk5jkCNta700ILwMNj5fi7oUX2rp3D-Rjeuk9Nt0X6Op-9WfIMUsORbJvIPa4Nanu6Ww1VzvyKCMtkPlFOZsK1vfGSw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":95655,"name":"Pharmaceutical","url":"https://www.academia.edu/Documents/in/Pharmaceutical"},{"id":113903,"name":"Bacteria","url":"https://www.academia.edu/Documents/in/Bacteria"},{"id":228471,"name":"Tears","url":"https://www.academia.edu/Documents/in/Tears"},{"id":245634,"name":"Eye","url":"https://www.academia.edu/Documents/in/Eye"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents"},{"id":784076,"name":"Species Specificity","url":"https://www.academia.edu/Documents/in/Species_Specificity"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"},{"id":984993,"name":"Residence Time","url":"https://www.academia.edu/Documents/in/Residence_Time"},{"id":1109769,"name":"Biological Assay","url":"https://www.academia.edu/Documents/in/Biological_Assay"},{"id":1136192,"name":"Biological Availability","url":"https://www.academia.edu/Documents/in/Biological_Availability"},{"id":1137112,"name":"Ophthalmic Solutions","url":"https://www.academia.edu/Documents/in/Ophthalmic_Solutions"},{"id":2467505,"name":"Gentamicins","url":"https://www.academia.edu/Documents/in/Gentamicins"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"},{"id":3986399,"name":"tissue adhesives","url":"https://www.academia.edu/Documents/in/tissue_adhesives"}],"urls":[{"id":15723560,"url":"http://www.springerlink.com/content/ewqwgmcm6dmvaqux"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069664"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069664/Efficacy_of_dinotefuran_permethrin_and_pyriproxyfen_combination_spot_on_on_dogs_against_Phlebotomus_perniciosus_and_Ctenocephalides_canis"><img alt="Research paper thumbnail of Efficacy of dinotefuran, permethrin and pyriproxyfen combination spot-on on dogs against Phlebotomus perniciosus and Ctenocephalides canis" class="work-thumbnail" src="https://attachments.academia-assets.com/77406273/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069664/Efficacy_of_dinotefuran_permethrin_and_pyriproxyfen_combination_spot_on_on_dogs_against_Phlebotomus_perniciosus_and_Ctenocephalides_canis">Efficacy of dinotefuran, permethrin and pyriproxyfen combination spot-on on dogs against Phlebotomus perniciosus and Ctenocephalides canis</a></div><div class="wp-workCard_item"><span>Parasitology Research</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="783155eddd4964f718ece7c0f0710688" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77406273,"asset_id":66069664,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77406273/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069664"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069664"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069664; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069664]").text(description); $(".js-view-count[data-work-id=66069664]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069664; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069664']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069664, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "783155eddd4964f718ece7c0f0710688" } } $('.js-work-strip[data-work-id=66069664]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069664,"title":"Efficacy of dinotefuran, permethrin and pyriproxyfen combination spot-on on dogs against Phlebotomus perniciosus and Ctenocephalides canis","translated_title":"","metadata":{"publisher":"Springer Nature","grobid_abstract":"This study was conducted to evaluate the efficacy of a new topical ectoparasiticidal spot-on containing 4.95 % dinotefuran (w /w), 36.08 % permethrin (w/w) and 0.44 % pyriproxyfen (w/w) (Vectra 3D™, Ceva, Libourne, France) against Portuguese strain of Phlebotomus perniciosus and a French strain of Ctenocephalides canis in dogs. Twelve beagle dogs were exposed for 1 h to 100 P. perniciosus on day 6 for allocation in two groups. One group was treated on day 0, and the other group was the control group. The dogs were exposed for 1 h to 100 P. perniciosus on days 1, 7, 14, 21 and 28. After each sandfly challenge, the same dogs were infested with 100 C. canis. Counts of living fleas were determined 48 h after infestation on days 4,","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Parasitology Research","grobid_abstract_attachment_id":77406273},"translated_abstract":null,"internal_url":"https://www.academia.edu/66069664/Efficacy_of_dinotefuran_permethrin_and_pyriproxyfen_combination_spot_on_on_dogs_against_Phlebotomus_perniciosus_and_Ctenocephalides_canis","translated_internal_url":"","created_at":"2021-12-26T23:44:32.652-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":77406273,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406273/thumbnails/1.jpg","file_name":"pmc3825486.pdf","download_url":"https://www.academia.edu/attachments/77406273/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Efficacy_of_dinotefuran_permethrin_and_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406273/pmc3825486-libre.pdf?1640595266=\u0026response-content-disposition=attachment%3B+filename%3DEfficacy_of_dinotefuran_permethrin_and_p.pdf\u0026Expires=1733024047\u0026Signature=DimV8DIh6D-VGSr3B-i4ExpwMiTr8s0j-g0UZQOSuZy8or2rt-jYyFgG9C98aenXss65KDQvyG2NhKE7KBFdLxP-5NIkNyUEKM1jciJN0NGbjP0uWmjobA8c7bBnY5YiGDu3uQMwiRjBBZA0ehMq7z12DiWyaojFrNcl93e~eu6G-2vZT67s7~oGDs-L9ca2Yz5~G5~Dtdi1rZ0qt73SE3ZNxve8U4QD~AfvZParynFu0GKoXX-crXwm81h5v2u6ltRQuKzR5~nb3u5auXxS6Pnlc9l~6IzFHRWOfHfz2KJR~cIzV-6LQyVeuSW-hZ-wd3EO0O5FlcQDLeVTwUu2Nw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Efficacy_of_dinotefuran_permethrin_and_pyriproxyfen_combination_spot_on_on_dogs_against_Phlebotomus_perniciosus_and_Ctenocephalides_canis","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[{"id":77406273,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406273/thumbnails/1.jpg","file_name":"pmc3825486.pdf","download_url":"https://www.academia.edu/attachments/77406273/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Efficacy_of_dinotefuran_permethrin_and_p.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406273/pmc3825486-libre.pdf?1640595266=\u0026response-content-disposition=attachment%3B+filename%3DEfficacy_of_dinotefuran_permethrin_and_p.pdf\u0026Expires=1733024047\u0026Signature=DimV8DIh6D-VGSr3B-i4ExpwMiTr8s0j-g0UZQOSuZy8or2rt-jYyFgG9C98aenXss65KDQvyG2NhKE7KBFdLxP-5NIkNyUEKM1jciJN0NGbjP0uWmjobA8c7bBnY5YiGDu3uQMwiRjBBZA0ehMq7z12DiWyaojFrNcl93e~eu6G-2vZT67s7~oGDs-L9ca2Yz5~G5~Dtdi1rZ0qt73SE3ZNxve8U4QD~AfvZParynFu0GKoXX-crXwm81h5v2u6ltRQuKzR5~nb3u5auXxS6Pnlc9l~6IzFHRWOfHfz2KJR~cIzV-6LQyVeuSW-hZ-wd3EO0O5FlcQDLeVTwUu2Nw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":164,"name":"Parasitology","url":"https://www.academia.edu/Documents/in/Parasitology"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis"},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":52972,"name":"Insecticides","url":"https://www.academia.edu/Documents/in/Insecticides"},{"id":490260,"name":"Pyridines","url":"https://www.academia.edu/Documents/in/Pyridines"},{"id":494759,"name":"Flea Infestations","url":"https://www.academia.edu/Documents/in/Flea_Infestations"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy"},{"id":644860,"name":"Veterinary Sciences","url":"https://www.academia.edu/Documents/in/Veterinary_Sciences"},{"id":801416,"name":"Guanidines","url":"https://www.academia.edu/Documents/in/Guanidines"},{"id":1552635,"name":"Phlebotomus","url":"https://www.academia.edu/Documents/in/Phlebotomus"},{"id":1825973,"name":"Ctenocephalides","url":"https://www.academia.edu/Documents/in/Ctenocephalides"},{"id":3002174,"name":"Permethrin","url":"https://www.academia.edu/Documents/in/Permethrin"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069662"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069662/Efficacy_of_Spironolactone_on_Survival_in_Dogs_with_Naturally_Occurring_Mitral_Regurgitation_Caused_by_Myxomatous_Mitral_Valve_Disease"><img alt="Research paper thumbnail of Efficacy of Spironolactone on Survival in Dogs with Naturally Occurring Mitral Regurgitation Caused by Myxomatous Mitral Valve Disease" class="work-thumbnail" src="https://attachments.academia-assets.com/77406278/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069662/Efficacy_of_Spironolactone_on_Survival_in_Dogs_with_Naturally_Occurring_Mitral_Regurgitation_Caused_by_Myxomatous_Mitral_Valve_Disease">Efficacy of Spironolactone on Survival in Dogs with Naturally Occurring Mitral Regurgitation Caused by Myxomatous Mitral Valve Disease</a></div><div class="wp-workCard_item"><span>Journal of Veterinary Internal Medicine</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9922183b052709fe06bd76cfc281bd15" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77406278,"asset_id":66069662,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77406278/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069662"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069662"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069662; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069662]").text(description); $(".js-view-count[data-work-id=66069662]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069662; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069662']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069662, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9922183b052709fe06bd76cfc281bd15" } } $('.js-work-strip[data-work-id=66069662]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069662,"title":"Efficacy of Spironolactone on Survival in Dogs with Naturally Occurring Mitral Regurgitation Caused by Myxomatous Mitral Valve Disease","translated_title":"","metadata":{"publisher":"Wiley-Blackwell","grobid_abstract":"Background: Spironolactone, an aldosterone antagonist, has been demonstrated to decrease mortality in human patients when added to other cardiac therapies. Hypothesis: Spironolactone in addition to conventional therapy increases survival compared with conventional therapy in dogs with naturally occurring myxomatous mitral valve disease (MMVD). Animals: Between February 2003 and March 2005, 221 dogs were recruited in Europe. Nine dogs were excluded from analysis, leaving 212 dogs with moderate to severe mitral regurgitation (MR) caused by MMVD (International Small Animal Cardiac Health Council classification classes II [n 5 190] and III [n 5 21]). Methods: Double-blinded, field study conducted with dogs randomized to receive either spironolactone (2 mg/kg once a day) or placebo in addition to conventional therapy (angiotensin converting enzyme inhibitor, plus furosemide and digoxin if needed). Primary endpoint was a composite of cardiac-related death, euthanasia, or severe worsening of MR. Results: Primary endpoint reached by 11/102 dogs (10.8%) in the spironolactone group (6 deaths, 5 worsening) versus 28/ 110 (25.5%) in control group (14 deaths, 8 euthanasia, 6 worsening). Risk of reaching the composite endpoint significantly decreased by 55% (hazard ratio [HR] 5 0.45; 95% confidence limits [CL], 0.22-0.90; log rank test, P 5 .017). Risk of cardiacrelated death or euthanasia significantly reduced by 69% (HR 5 0.31; 95% CL, 0.13-0.76; P 5 .0071). Number of dogs not completing the study for cardiac and other miscellaneous reasons similar in spironolactone (67/102) and control groups (66/110). Conclusion and Clinical Importance: Spironolactone added to conventional cardiac therapy decreases the risk of reaching the primary endpoint (ie, cardiac-related death, euthanasia, or severe worsening) in dogs with moderate to severe MR caused by MMVD.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of Veterinary Internal Medicine","grobid_abstract_attachment_id":77406278},"translated_abstract":null,"internal_url":"https://www.academia.edu/66069662/Efficacy_of_Spironolactone_on_Survival_in_Dogs_with_Naturally_Occurring_Mitral_Regurgitation_Caused_by_Myxomatous_Mitral_Valve_Disease","translated_internal_url":"","created_at":"2021-12-26T23:44:32.536-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":77406278,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406278/thumbnails/1.jpg","file_name":"Efficacy_20of_20Spironolactone_20on_20Survival_20in_20Dogs_20with_20Naturally.pdf","download_url":"https://www.academia.edu/attachments/77406278/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Efficacy_of_Spironolactone_on_Survival_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406278/Efficacy_20of_20Spironolactone_20on_20Survival_20in_20Dogs_20with_20Naturally-libre.pdf?1640595265=\u0026response-content-disposition=attachment%3B+filename%3DEfficacy_of_Spironolactone_on_Survival_i.pdf\u0026Expires=1733024047\u0026Signature=MvyleUPEP-mAs3evraLMcVyzDnKZ~gybQh0ZUc6Nqzu4K2bFFDXan2K0ZbARN3ZLKaYMIaePmD21hbF2EY58zbP1f03xtZ82q6S-C6rb8oRtbnVdGA7L36vTGX-F-acygsImI0IyrwXcvwtF3AlaREEJQMat9VwiJlXdZzUakpKNjaNJLmHxe-66srrulj8PqpbJm9X4lwZHj61HTHsV7Ax~YqMtlRyaXTZ1Ae~OQTMEaX~QgrfFJ-DMa-t27sl3eAdzB-GKQUVSPp9Vla9HoEvUJXFJS2kNM8CVEb~LySDYXBw2mHpUh3~RMUYclJh8Bv~uAZdBwTrsHRi8d0IJAg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Efficacy_of_Spironolactone_on_Survival_in_Dogs_with_Naturally_Occurring_Mitral_Regurgitation_Caused_by_Myxomatous_Mitral_Valve_Disease","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[{"id":77406278,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406278/thumbnails/1.jpg","file_name":"Efficacy_20of_20Spironolactone_20on_20Survival_20in_20Dogs_20with_20Naturally.pdf","download_url":"https://www.academia.edu/attachments/77406278/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Efficacy_of_Spironolactone_on_Survival_i.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406278/Efficacy_20of_20Spironolactone_20on_20Survival_20in_20Dogs_20with_20Naturally-libre.pdf?1640595265=\u0026response-content-disposition=attachment%3B+filename%3DEfficacy_of_Spironolactone_on_Survival_i.pdf\u0026Expires=1733024047\u0026Signature=MvyleUPEP-mAs3evraLMcVyzDnKZ~gybQh0ZUc6Nqzu4K2bFFDXan2K0ZbARN3ZLKaYMIaePmD21hbF2EY58zbP1f03xtZ82q6S-C6rb8oRtbnVdGA7L36vTGX-F-acygsImI0IyrwXcvwtF3AlaREEJQMat9VwiJlXdZzUakpKNjaNJLmHxe-66srrulj8PqpbJm9X4lwZHj61HTHsV7Ax~YqMtlRyaXTZ1Ae~OQTMEaX~QgrfFJ-DMa-t27sl3eAdzB-GKQUVSPp9Vla9HoEvUJXFJS2kNM8CVEb~LySDYXBw2mHpUh3~RMUYclJh8Bv~uAZdBwTrsHRi8d0IJAg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":89995,"name":"Diuretics","url":"https://www.academia.edu/Documents/in/Diuretics"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy"},{"id":644860,"name":"Veterinary Sciences","url":"https://www.academia.edu/Documents/in/Veterinary_Sciences"},{"id":977495,"name":"Digoxin","url":"https://www.academia.edu/Documents/in/Digoxin"},{"id":1135799,"name":"Furosemide","url":"https://www.academia.edu/Documents/in/Furosemide"},{"id":1227768,"name":"Angiotensin Converting Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme_Inhibitors"},{"id":1272981,"name":"Proportional Hazards Models","url":"https://www.academia.edu/Documents/in/Proportional_Hazards_Models"},{"id":1749710,"name":"Veterinary Internal Medicine","url":"https://www.academia.edu/Documents/in/Veterinary_Internal_Medicine"},{"id":2057471,"name":"Mitral regurgitation","url":"https://www.academia.edu/Documents/in/Mitral_regurgitation"},{"id":2990585,"name":"mitral valve disease","url":"https://www.academia.edu/Documents/in/mitral_valve_disease"},{"id":3329465,"name":"Spironolactone","url":"https://www.academia.edu/Documents/in/Spironolactone"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069661"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069661/Evaluation_of_Soluble_Bioadhesive_Ophthalmic_Drug_Inserts_BODI_for_Prolonged_Release_of_Gentamicin_Lachrymal_Pharmacokinetics_and_Ocular_Tolerance"><img alt="Research paper thumbnail of Evaluation of Soluble Bioadhesive Ophthalmic Drug Inserts (BODI®) for Prolonged Release of Gentamicin: Lachrymal Pharmacokinetics and Ocular Tolerance" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069661/Evaluation_of_Soluble_Bioadhesive_Ophthalmic_Drug_Inserts_BODI_for_Prolonged_Release_of_Gentamicin_Lachrymal_Pharmacokinetics_and_Ocular_Tolerance">Evaluation of Soluble Bioadhesive Ophthalmic Drug Inserts (BODI®) for Prolonged Release of Gentamicin: Lachrymal Pharmacokinetics and Ocular Tolerance</a></div><div class="wp-workCard_item"><span>Journal of Ocular Pharmacology and Therapeutics</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The purpose of this investigation was the evaluation of Bioadhesive Ophthalmic Drug Inserts (BODI...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The purpose of this investigation was the evaluation of Bioadhesive Ophthalmic Drug Inserts (BODI) for prolonged release of gentamicin sulfate (GS) in tears. The BODIs (length 5.0 mm, diameter 2.0 mm, weight 20.5 mg, average GS content 5.0 mg) were prepared by extrusion of a mixture based on hydroxypropylcellulose (HPC), ethylcellulose (EC) and carbomer. Two methods were tested to prolong the release of GS in tears: (1) preliminary treatment of GS and (2) use of a less hydrophilic polymer than HPC, hydroxypropylmethylcellulose (HPMC), as a vehicle constituent. The preliminary treatment consisted of the formation of a GS/cellulose acetate phthalate (CAP) solid dispersion (ratio GS/CAP: 10/6) made in acetonic medium, and in the coating of GS/EC granules (GS/EC ratio: 10/0.5) with an aqueous dispersion of CAP, to form a GS/EC/CAP coprecipitate (GS/EC/CAP ratio: 10/0.5/6). Inserts containing GS/CAP solid dispersion, GS/EC/CAP coprecipitate and HPMC resulted in improved time of efficacy (t(eff)) (43.8, 23.3, and 33.1 h, respectively), when compared to inserts containing GS without preliminary treatment (t(eff) = 11.9 h). A high irritation level was observed for inserts containing the GS/EC/CAP and HPMC. A relation between t(eff) and irritation score was established, emphasizing the importance of irritability as a factor during the evaluation of the potential of these systems.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069661"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069661"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069661; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069661]").text(description); $(".js-view-count[data-work-id=66069661]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069661; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069661']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069661, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069661]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069661,"title":"Evaluation of Soluble Bioadhesive Ophthalmic Drug Inserts (BODI®) for Prolonged Release of Gentamicin: Lachrymal Pharmacokinetics and Ocular Tolerance","translated_title":"","metadata":{"abstract":"The purpose of this investigation was the evaluation of Bioadhesive Ophthalmic Drug Inserts (BODI) for prolonged release of gentamicin sulfate (GS) in tears. The BODIs (length 5.0 mm, diameter 2.0 mm, weight 20.5 mg, average GS content 5.0 mg) were prepared by extrusion of a mixture based on hydroxypropylcellulose (HPC), ethylcellulose (EC) and carbomer. Two methods were tested to prolong the release of GS in tears: (1) preliminary treatment of GS and (2) use of a less hydrophilic polymer than HPC, hydroxypropylmethylcellulose (HPMC), as a vehicle constituent. The preliminary treatment consisted of the formation of a GS/cellulose acetate phthalate (CAP) solid dispersion (ratio GS/CAP: 10/6) made in acetonic medium, and in the coating of GS/EC granules (GS/EC ratio: 10/0.5) with an aqueous dispersion of CAP, to form a GS/EC/CAP coprecipitate (GS/EC/CAP ratio: 10/0.5/6). Inserts containing GS/CAP solid dispersion, GS/EC/CAP coprecipitate and HPMC resulted in improved time of efficacy (t(eff)) (43.8, 23.3, and 33.1 h, respectively), when compared to inserts containing GS without preliminary treatment (t(eff) = 11.9 h). A high irritation level was observed for inserts containing the GS/EC/CAP and HPMC. A relation between t(eff) and irritation score was established, emphasizing the importance of irritability as a factor during the evaluation of the potential of these systems.","publisher":"Mary Ann Liebert Inc","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Journal of Ocular Pharmacology and Therapeutics"},"translated_abstract":"The purpose of this investigation was the evaluation of Bioadhesive Ophthalmic Drug Inserts (BODI) for prolonged release of gentamicin sulfate (GS) in tears. The BODIs (length 5.0 mm, diameter 2.0 mm, weight 20.5 mg, average GS content 5.0 mg) were prepared by extrusion of a mixture based on hydroxypropylcellulose (HPC), ethylcellulose (EC) and carbomer. Two methods were tested to prolong the release of GS in tears: (1) preliminary treatment of GS and (2) use of a less hydrophilic polymer than HPC, hydroxypropylmethylcellulose (HPMC), as a vehicle constituent. The preliminary treatment consisted of the formation of a GS/cellulose acetate phthalate (CAP) solid dispersion (ratio GS/CAP: 10/6) made in acetonic medium, and in the coating of GS/EC granules (GS/EC ratio: 10/0.5) with an aqueous dispersion of CAP, to form a GS/EC/CAP coprecipitate (GS/EC/CAP ratio: 10/0.5/6). Inserts containing GS/CAP solid dispersion, GS/EC/CAP coprecipitate and HPMC resulted in improved time of efficacy (t(eff)) (43.8, 23.3, and 33.1 h, respectively), when compared to inserts containing GS without preliminary treatment (t(eff) = 11.9 h). A high irritation level was observed for inserts containing the GS/EC/CAP and HPMC. A relation between t(eff) and irritation score was established, emphasizing the importance of irritability as a factor during the evaluation of the potential of these systems.","internal_url":"https://www.academia.edu/66069661/Evaluation_of_Soluble_Bioadhesive_Ophthalmic_Drug_Inserts_BODI_for_Prolonged_Release_of_Gentamicin_Lachrymal_Pharmacokinetics_and_Ocular_Tolerance","translated_internal_url":"","created_at":"2021-12-26T23:44:32.421-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Evaluation_of_Soluble_Bioadhesive_Ophthalmic_Drug_Inserts_BODI_for_Prolonged_Release_of_Gentamicin_Lachrymal_Pharmacokinetics_and_Ocular_Tolerance","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":228471,"name":"Tears","url":"https://www.academia.edu/Documents/in/Tears"},{"id":245634,"name":"Eye","url":"https://www.academia.edu/Documents/in/Eye"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents"},{"id":359001,"name":"Optometry and Ophthalmology","url":"https://www.academia.edu/Documents/in/Optometry_and_Ophthalmology"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"},{"id":1136192,"name":"Biological Availability","url":"https://www.academia.edu/Documents/in/Biological_Availability"},{"id":1137112,"name":"Ophthalmic Solutions","url":"https://www.academia.edu/Documents/in/Ophthalmic_Solutions"},{"id":1309706,"name":"Area Under Curve","url":"https://www.academia.edu/Documents/in/Area_Under_Curve"},{"id":2467505,"name":"Gentamicins","url":"https://www.academia.edu/Documents/in/Gentamicins"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"},{"id":3986399,"name":"tissue adhesives","url":"https://www.academia.edu/Documents/in/tissue_adhesives"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069660"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069660/Long_acting_soluble_bioadhesive_ophthalmic_drug_insert_BODI_containing_gentamicin_for_veterinary_use_optimization_and_clinical_investigation"><img alt="Research paper thumbnail of Long-acting soluble bioadhesive ophthalmic drug insert (BODI) containing gentamicin for veterinary use: optimization and clinical investigation" class="work-thumbnail" src="https://attachments.academia-assets.com/77406332/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069660/Long_acting_soluble_bioadhesive_ophthalmic_drug_insert_BODI_containing_gentamicin_for_veterinary_use_optimization_and_clinical_investigation">Long-acting soluble bioadhesive ophthalmic drug insert (BODI) containing gentamicin for veterinary use: optimization and clinical investigation</a></div><div class="wp-workCard_item"><span>Journal of Controlled Release</span><span>, 1995</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cec668ba83586b0813231b16a62f035d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77406332,"asset_id":66069660,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77406332/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069660"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069660"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069660; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069660]").text(description); $(".js-view-count[data-work-id=66069660]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069660; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069660']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069660, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cec668ba83586b0813231b16a62f035d" } } $('.js-work-strip[data-work-id=66069660]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069660,"title":"Long-acting soluble bioadhesive ophthalmic drug insert (BODI) containing gentamicin for veterinary use: optimization and clinical investigation","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"In animal health care, current therapeutic regimens for severe external infections require repeated instillations of antibiotic eye drop solutions. The aim of this work is to drastically decrease the frequency of instillations by developing a long-acting ophthalmic insert. Ophthalmic inserts based on mixtures of hydroxypropyl cellulose, ethyl cellulose, poly(acrylic) acid and 25.0% (w/w) of gentamicin sulfate either combined with cellulose acetate phthalate or not were prepared using a specially designed ram extruder. The content of each component was optimized by evaluating tolerance and drug release in rabbits. Preliminary in vivo assays in rabbits led to a formulation with the favourable characteristics needed. These inserts were tested in dogs for drug release and compared with a commercially sold collyrium. The results show that the inserts ensure effective gentamicin levels over 72 h with variation coefficients between 2 and 10%. These results are compared with those obtained with the eye drop solution (0.3%), which provides effective concentrations lasting less than 15 min with variation coefficients ranging from 63-96%. These soluble Bioadhesive Ophthalmic Drug Inserts (BODI) can be considered as a promising new ophthalmic delivery concept specifically designed for animal health care.","publication_date":{"day":null,"month":null,"year":1995,"errors":{}},"publication_name":"Journal of Controlled Release","grobid_abstract_attachment_id":77406332},"translated_abstract":null,"internal_url":"https://www.academia.edu/66069660/Long_acting_soluble_bioadhesive_ophthalmic_drug_insert_BODI_containing_gentamicin_for_veterinary_use_optimization_and_clinical_investigation","translated_internal_url":"","created_at":"2021-12-26T23:44:32.305-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":77406332,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406332/thumbnails/1.jpg","file_name":"0168-3659_2894_2900096-d20211226-23550-j6u10r.pdf","download_url":"https://www.academia.edu/attachments/77406332/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Long_acting_soluble_bioadhesive_ophthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406332/0168-3659_2894_2900096-d20211226-23550-j6u10r-libre.pdf?1640595262=\u0026response-content-disposition=attachment%3B+filename%3DLong_acting_soluble_bioadhesive_ophthalm.pdf\u0026Expires=1733024047\u0026Signature=Mlr1e318HiPT-KgUTodrpusAlpPSFLXYxeQu19vWnd7feAHZQuIeZ4BDIIgXj0o4YNWX5ujvxI~OT5XRhE2TZowDw3h2Zu28Ffew7x~-F-PYCpe-Wuq5f5jvTSwqH2ss9uSs1w1RohOlkojVGeYHzXG4ByUIYqvYX2n-gYzqHCFY3G3DW1KvffqL7hTfYI0OrVJ8pqv0MwqcR5KY7s8H6-x4S~HSGgr8LMKttmbhMxGVgVN01NlVH-but4FcLusVP3DSOitIK9GxkPhhiCG50RHDOxeRrJ7ylykFiQvrubWtW2y0S7UoqYC~lSRMTqtW0IqD1-APkWlLtJzAhAls2w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Long_acting_soluble_bioadhesive_ophthalmic_drug_insert_BODI_containing_gentamicin_for_veterinary_use_optimization_and_clinical_investigation","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[{"id":77406332,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406332/thumbnails/1.jpg","file_name":"0168-3659_2894_2900096-d20211226-23550-j6u10r.pdf","download_url":"https://www.academia.edu/attachments/77406332/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Long_acting_soluble_bioadhesive_ophthalm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406332/0168-3659_2894_2900096-d20211226-23550-j6u10r-libre.pdf?1640595262=\u0026response-content-disposition=attachment%3B+filename%3DLong_acting_soluble_bioadhesive_ophthalm.pdf\u0026Expires=1733024047\u0026Signature=Mlr1e318HiPT-KgUTodrpusAlpPSFLXYxeQu19vWnd7feAHZQuIeZ4BDIIgXj0o4YNWX5ujvxI~OT5XRhE2TZowDw3h2Zu28Ffew7x~-F-PYCpe-Wuq5f5jvTSwqH2ss9uSs1w1RohOlkojVGeYHzXG4ByUIYqvYX2n-gYzqHCFY3G3DW1KvffqL7hTfYI0OrVJ8pqv0MwqcR5KY7s8H6-x4S~HSGgr8LMKttmbhMxGVgVN01NlVH-but4FcLusVP3DSOitIK9GxkPhhiCG50RHDOxeRrJ7ylykFiQvrubWtW2y0S7UoqYC~lSRMTqtW0IqD1-APkWlLtJzAhAls2w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":657,"name":"Veterinary Medicine","url":"https://www.academia.edu/Documents/in/Veterinary_Medicine"},{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery"},{"id":28505,"name":"Adhesion","url":"https://www.academia.edu/Documents/in/Adhesion"},{"id":41747,"name":"Dosage Form","url":"https://www.academia.edu/Documents/in/Dosage_Form"},{"id":64660,"name":"Controlled release","url":"https://www.academia.edu/Documents/in/Controlled_release"},{"id":119176,"name":"Animal health","url":"https://www.academia.edu/Documents/in/Animal_health"},{"id":245634,"name":"Eye","url":"https://www.academia.edu/Documents/in/Eye"},{"id":1136003,"name":"Cellulose Acetate","url":"https://www.academia.edu/Documents/in/Cellulose_Acetate"},{"id":1139957,"name":"Drug Release","url":"https://www.academia.edu/Documents/in/Drug_Release"},{"id":1303345,"name":"Poly Acrylic Acid","url":"https://www.academia.edu/Documents/in/Poly_Acrylic_Acid"},{"id":2282998,"name":"Insert","url":"https://www.academia.edu/Documents/in/Insert"},{"id":2296520,"name":"Ethyl Cellulose","url":"https://www.academia.edu/Documents/in/Ethyl_Cellulose-1"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069659"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069659/Cephradin_plaga_microspheres_for_sustained_delivery_to_cattle"><img alt="Research paper thumbnail of Cephradin-plaga microspheres for sustained delivery to cattle" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069659/Cephradin_plaga_microspheres_for_sustained_delivery_to_cattle">Cephradin-plaga microspheres for sustained delivery to cattle</a></div><div class="wp-workCard_item"><span>Journal of microencapsulation</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the field of controlled drug delivery, most of the reported work is aimed at introducing new s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the field of controlled drug delivery, most of the reported work is aimed at introducing new systems, or at providing basic information on the critical parameters which affect release profiles in vitro and occasionally in vivo. The situation is totally different when one wants to ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069659"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069659"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069659; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069659]").text(description); $(".js-view-count[data-work-id=66069659]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069659; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069659']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069659, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069659]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069659,"title":"Cephradin-plaga microspheres for sustained delivery to cattle","translated_title":"","metadata":{"abstract":"In the field of controlled drug delivery, most of the reported work is aimed at introducing new systems, or at providing basic information on the critical parameters which affect release profiles in vitro and occasionally in vivo. The situation is totally different when one wants to ...","publisher":"informahealthcare.com","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Journal of microencapsulation"},"translated_abstract":"In the field of controlled drug delivery, most of the reported work is aimed at introducing new systems, or at providing basic information on the critical parameters which affect release profiles in vitro and occasionally in vivo. The situation is totally different when one wants to ...","internal_url":"https://www.academia.edu/66069659/Cephradin_plaga_microspheres_for_sustained_delivery_to_cattle","translated_internal_url":"","created_at":"2021-12-26T23:44:32.139-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Cephradin_plaga_microspheres_for_sustained_delivery_to_cattle","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":511,"name":"Materials Science","url":"https://www.academia.edu/Documents/in/Materials_Science"},{"id":532,"name":"Physical Chemistry","url":"https://www.academia.edu/Documents/in/Physical_Chemistry"},{"id":21466,"name":"Polymers","url":"https://www.academia.edu/Documents/in/Polymers"},{"id":23390,"name":"Pharmaceutical Chemistry","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs"},{"id":57800,"name":"Microencapsulation","url":"https://www.academia.edu/Documents/in/Microencapsulation"},{"id":161226,"name":"Cephalosporins","url":"https://www.academia.edu/Documents/in/Cephalosporins"},{"id":260829,"name":"Cattle","url":"https://www.academia.edu/Documents/in/Cattle"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"},{"id":794074,"name":"Microspheres","url":"https://www.academia.edu/Documents/in/Microspheres"},{"id":1074508,"name":"Lactic Acid","url":"https://www.academia.edu/Documents/in/Lactic_Acid"},{"id":1137107,"name":"Delayed-Action Preparations","url":"https://www.academia.edu/Documents/in/Delayed-Action_Preparations"},{"id":1745595,"name":"Solvents","url":"https://www.academia.edu/Documents/in/Solvents"},{"id":1842148,"name":"Cephradine","url":"https://www.academia.edu/Documents/in/Cephradine"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":15723559,"url":"http://direct.bl.uk/research/5E/32/RN057045980.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069658"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069658/Labile_conjugation_of_a_hydrophilic_drug_to_PLA_oligomers_to_modify_a_drug_delivery_system_cephradin_in_a_PLAGA_matrix"><img alt="Research paper thumbnail of Labile conjugation of a hydrophilic drug to PLA oligomers to modify a drug delivery system: cephradin in a PLAGA matrix" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069658/Labile_conjugation_of_a_hydrophilic_drug_to_PLA_oligomers_to_modify_a_drug_delivery_system_cephradin_in_a_PLAGA_matrix">Labile conjugation of a hydrophilic drug to PLA oligomers to modify a drug delivery system: cephradin in a PLAGA matrix</a></div><div class="wp-workCard_item"><span>Journal of …</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficult because of poor entrapment yield and/or fast release, depending on the microsphere fabrication method. In order to counter the effects of drug hydrophilicity, it is proposed to ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069658"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069658"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069658; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069658]").text(description); $(".js-view-count[data-work-id=66069658]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069658; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069658']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069658, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069658]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069658,"title":"Labile conjugation of a hydrophilic drug to PLA oligomers to modify a drug delivery system: cephradin in a PLAGA matrix","translated_title":"","metadata":{"abstract":"The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficult because of poor entrapment yield and/or fast release, depending on the microsphere fabrication method. In order to counter the effects of drug hydrophilicity, it is proposed to ...","publisher":"informahealthcare.com","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"Journal of …"},"translated_abstract":"The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficult because of poor entrapment yield and/or fast release, depending on the microsphere fabrication method. In order to counter the effects of drug hydrophilicity, it is proposed to ...","internal_url":"https://www.academia.edu/66069658/Labile_conjugation_of_a_hydrophilic_drug_to_PLA_oligomers_to_modify_a_drug_delivery_system_cephradin_in_a_PLAGA_matrix","translated_internal_url":"","created_at":"2021-12-26T23:44:31.926-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Labile_conjugation_of_a_hydrophilic_drug_to_PLA_oligomers_to_modify_a_drug_delivery_system_cephradin_in_a_PLAGA_matrix","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":21466,"name":"Polymers","url":"https://www.academia.edu/Documents/in/Polymers"},{"id":57800,"name":"Microencapsulation","url":"https://www.academia.edu/Documents/in/Microencapsulation"},{"id":83128,"name":"Escherichia coli","url":"https://www.academia.edu/Documents/in/Escherichia_coli"},{"id":116078,"name":"Staphylococcus aureus","url":"https://www.academia.edu/Documents/in/Staphylococcus_aureus"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems"},{"id":995181,"name":"Capsules","url":"https://www.academia.edu/Documents/in/Capsules"},{"id":1074508,"name":"Lactic Acid","url":"https://www.academia.edu/Documents/in/Lactic_Acid"},{"id":1135812,"name":"Drug Compounding","url":"https://www.academia.edu/Documents/in/Drug_Compounding"},{"id":1137107,"name":"Delayed-Action Preparations","url":"https://www.academia.edu/Documents/in/Delayed-Action_Preparations"},{"id":1842148,"name":"Cephradine","url":"https://www.academia.edu/Documents/in/Cephradine"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"},{"id":3881526,"name":"In Vitro Techniques","url":"https://www.academia.edu/Documents/in/In_Vitro_Techniques"}],"urls":[{"id":15723558,"url":"http://direct.bl.uk/research/34/0C/RN083560630.html"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069657"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069657/Optimized_release_of_dexamethasone_and_gentamicin_from_a_soluble_ocular_insert_for_the_treatment_of_external_ophthalmic_infections"><img alt="Research paper thumbnail of Optimized release of dexamethasone and gentamicin from a soluble ocular insert for the treatment of external ophthalmic infections" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069657/Optimized_release_of_dexamethasone_and_gentamicin_from_a_soluble_ocular_insert_for_the_treatment_of_external_ophthalmic_infections">Optimized release of dexamethasone and gentamicin from a soluble ocular insert for the treatment of external ophthalmic infections</a></div><div class="wp-workCard_item"><span>Journal of controlled …</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the case of external ophthalmic infections, repeated instillations of antibiotics are required...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the case of external ophthalmic infections, repeated instillations of antibiotics are required to reach therapeutic level, above the minimal inhibitory concentration (MIC). An additional administration of a corticosteroid is often needed, in order to limit the precorneal damages caused by the infection. However, repeated administration of a corticosteroid can increase intraocular pressure and thus lead to glaucoma. To overcome the disadvantages of separated and repeated instillations of two products and to avoid the side effects of dexamethasone, a soluble insert containing gentamicin sulfate and dexamethasone phosphate was developed. The new system ensures the concomitant release of the two drugs during the first 10 h of treatment, followed by an adequate concentration of gentamicin sulfate, above the MIC of 4.0 microgram ml-1, during 50 h, due to a combination of gentamicin sulfate with cellulose acetate phthalate, which reduces the solubility of gentamicin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069657"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069657"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069657; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069657]").text(description); $(".js-view-count[data-work-id=66069657]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069657; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069657']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069657, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069657]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069657,"title":"Optimized release of dexamethasone and gentamicin from a soluble ocular insert for the treatment of external ophthalmic infections","translated_title":"","metadata":{"abstract":"In the case of external ophthalmic infections, repeated instillations of antibiotics are required to reach therapeutic level, above the minimal inhibitory concentration (MIC). An additional administration of a corticosteroid is often needed, in order to limit the precorneal damages caused by the infection. However, repeated administration of a corticosteroid can increase intraocular pressure and thus lead to glaucoma. To overcome the disadvantages of separated and repeated instillations of two products and to avoid the side effects of dexamethasone, a soluble insert containing gentamicin sulfate and dexamethasone phosphate was developed. The new system ensures the concomitant release of the two drugs during the first 10 h of treatment, followed by an adequate concentration of gentamicin sulfate, above the MIC of 4.0 microgram ml-1, during 50 h, due to a combination of gentamicin sulfate with cellulose acetate phthalate, which reduces the solubility of gentamicin.","publisher":"Elsevier","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Journal of controlled …"},"translated_abstract":"In the case of external ophthalmic infections, repeated instillations of antibiotics are required to reach therapeutic level, above the minimal inhibitory concentration (MIC). An additional administration of a corticosteroid is often needed, in order to limit the precorneal damages caused by the infection. However, repeated administration of a corticosteroid can increase intraocular pressure and thus lead to glaucoma. To overcome the disadvantages of separated and repeated instillations of two products and to avoid the side effects of dexamethasone, a soluble insert containing gentamicin sulfate and dexamethasone phosphate was developed. The new system ensures the concomitant release of the two drugs during the first 10 h of treatment, followed by an adequate concentration of gentamicin sulfate, above the MIC of 4.0 microgram ml-1, during 50 h, due to a combination of gentamicin sulfate with cellulose acetate phthalate, which reduces the solubility of gentamicin.","internal_url":"https://www.academia.edu/66069657/Optimized_release_of_dexamethasone_and_gentamicin_from_a_soluble_ocular_insert_for_the_treatment_of_external_ophthalmic_infections","translated_internal_url":"","created_at":"2021-12-26T23:44:31.823-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Optimized_release_of_dexamethasone_and_gentamicin_from_a_soluble_ocular_insert_for_the_treatment_of_external_ophthalmic_infections","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":57801,"name":"Dexamethasone","url":"https://www.academia.edu/Documents/in/Dexamethasone"},{"id":64660,"name":"Controlled release","url":"https://www.academia.edu/Documents/in/Controlled_release"},{"id":121320,"name":"Intraocular Pressure","url":"https://www.academia.edu/Documents/in/Intraocular_Pressure"},{"id":159187,"name":"Drug Delivery Systems","url":"https://www.academia.edu/Documents/in/Drug_Delivery_Systems"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents"},{"id":698785,"name":"Side Effect","url":"https://www.academia.edu/Documents/in/Side_Effect"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"},{"id":1136003,"name":"Cellulose Acetate","url":"https://www.academia.edu/Documents/in/Cellulose_Acetate"},{"id":2282998,"name":"Insert","url":"https://www.academia.edu/Documents/in/Insert"},{"id":2467505,"name":"Gentamicins","url":"https://www.academia.edu/Documents/in/Gentamicins"},{"id":2764779,"name":"minimal inhibitory concentration","url":"https://www.academia.edu/Documents/in/minimal_inhibitory_concentration"},{"id":3421103,"name":"Eye infections","url":"https://www.academia.edu/Documents/in/Eye_infections"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069656"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069656/Determination_of_a_dosage_regimen_of_colistin_by_pharmacokinetic_pharmacodynamic_integration_and_modeling_for_treatment_of_GIT_disease_in_pigs"><img alt="Research paper thumbnail of Determination of a dosage regimen of colistin by pharmacokinetic/pharmacodynamic integration and modeling for treatment of GIT disease in pigs" class="work-thumbnail" src="https://attachments.academia-assets.com/77406287/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069656/Determination_of_a_dosage_regimen_of_colistin_by_pharmacokinetic_pharmacodynamic_integration_and_modeling_for_treatment_of_GIT_disease_in_pigs">Determination of a dosage regimen of colistin by pharmacokinetic/pharmacodynamic integration and modeling for treatment of GIT disease in pigs</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3047706330a1b0cc611ad5f7259681a1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77406287,"asset_id":66069656,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77406287/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069656"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069656"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069656; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069656]").text(description); $(".js-view-count[data-work-id=66069656]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069656; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069656']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069656, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3047706330a1b0cc611ad5f7259681a1" } } $('.js-work-strip[data-work-id=66069656]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069656,"title":"Determination of a dosage regimen of colistin by pharmacokinetic/pharmacodynamic integration and modeling for treatment of GIT disease in pigs","translated_title":"","metadata":{"grobid_abstract":"Colistin is an antimicrobial drug of the polymyxin group and COLIVET SOLUTION is an aqueous solution containing colistin sulphate (2 Â 10 6 IU/mL), formulated for oral administration. The target species is the pig, particularly the suckling and post weaning animal. This investigation was undertaken to provide pharmacokinetic and pharmacodynamic data on which to base the selection of dosage rate and interval of the solution for the treatment of porcine colibacillosis. Colistin absorption from the gastrointestinal tract of young pigs, when administered at dosage rates of 25,000, 50,000 and 1,00,000 IU/kg, was slight or absent. The drug was therefore restricted almost entirely to the required site of action. The colistin concentration-time profile within the jejunum and ileum was established, and this enabled determination of the pharmacokinetic variables, maximum concentration (C max) and area under curve (AUC) and derivation of the surrogate indices of antibacterial activity, C max /minimum inhibitory concentration (MIC) and AUC/MIC through integration of in vivo data with the results of in vitro potency studies for four strains of Escherichia coli. In the in vitro bacterial growth inhibition studies colistin acted by a concentration-dependent killing mechanism. Numerical values for the surrogate parameter AUC/MIC producing bactericidal and eradication effects of colistin against four strains of E. coli were established by PK-PD modeling based on the sigmoidal E max equation. These data were used to predict a daily dosage regimen for colistin.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"grobid_abstract_attachment_id":77406287},"translated_abstract":null,"internal_url":"https://www.academia.edu/66069656/Determination_of_a_dosage_regimen_of_colistin_by_pharmacokinetic_pharmacodynamic_integration_and_modeling_for_treatment_of_GIT_disease_in_pigs","translated_internal_url":"","created_at":"2021-12-26T23:44:31.711-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":77406287,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406287/thumbnails/1.jpg","file_name":"j.rvsc.2009.09.00120211226-20106-175klfz.pdf","download_url":"https://www.academia.edu/attachments/77406287/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Determination_of_a_dosage_regimen_of_col.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406287/j.rvsc.2009.09.00120211226-20106-175klfz-libre.pdf?1640595264=\u0026response-content-disposition=attachment%3B+filename%3DDetermination_of_a_dosage_regimen_of_col.pdf\u0026Expires=1733024047\u0026Signature=F3HC2jl7SxnX6o1Gzl~GWF6HKkXixZT1prqjcpcDYXrDR-xKenxXBw6PFxIDmUPQAGCpG7t4LYj9GdAsz5VGrL9BfkgIlcjgO6rI3ld-TuTo4MTGmOCNXPqRo7a5PuTethfJixhlB6Qfx0qlSCK-4UUR4u1rGBJ28536dARTw5sgllMkMcTCjX6DinaaZS3t9EW1MaqgcOACuIHec5XzRLYkAxlpoQtKqEsfR~CsYAjkvJq9e7w4UTmcjL7zQ2wLOOCal8wYB103VOp9oVAfqVCC~m-eeaa-yzIOcdyfnBMDD0WUCl0qCzMiyHlxaYg-ldGL7DlXWB2DuTfl~kkFyQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Determination_of_a_dosage_regimen_of_colistin_by_pharmacokinetic_pharmacodynamic_integration_and_modeling_for_treatment_of_GIT_disease_in_pigs","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[{"id":77406287,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77406287/thumbnails/1.jpg","file_name":"j.rvsc.2009.09.00120211226-20106-175klfz.pdf","download_url":"https://www.academia.edu/attachments/77406287/download_file?st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&st=MTczMzAyMDQ0Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Determination_of_a_dosage_regimen_of_col.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77406287/j.rvsc.2009.09.00120211226-20106-175klfz-libre.pdf?1640595264=\u0026response-content-disposition=attachment%3B+filename%3DDetermination_of_a_dosage_regimen_of_col.pdf\u0026Expires=1733024047\u0026Signature=F3HC2jl7SxnX6o1Gzl~GWF6HKkXixZT1prqjcpcDYXrDR-xKenxXBw6PFxIDmUPQAGCpG7t4LYj9GdAsz5VGrL9BfkgIlcjgO6rI3ld-TuTo4MTGmOCNXPqRo7a5PuTethfJixhlB6Qfx0qlSCK-4UUR4u1rGBJ28536dARTw5sgllMkMcTCjX6DinaaZS3t9EW1MaqgcOACuIHec5XzRLYkAxlpoQtKqEsfR~CsYAjkvJq9e7w4UTmcjL7zQ2wLOOCal8wYB103VOp9oVAfqVCC~m-eeaa-yzIOcdyfnBMDD0WUCl0qCzMiyHlxaYg-ldGL7DlXWB2DuTfl~kkFyQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":29980,"name":"Animal Production","url":"https://www.academia.edu/Documents/in/Animal_Production"},{"id":43294,"name":"Veterinary Science","url":"https://www.academia.edu/Documents/in/Veterinary_Science"},{"id":83128,"name":"Escherichia coli","url":"https://www.academia.edu/Documents/in/Escherichia_coli"},{"id":290432,"name":"Antibacterial activity","url":"https://www.academia.edu/Documents/in/Antibacterial_activity"},{"id":335984,"name":"Anti-Bacterial Agents","url":"https://www.academia.edu/Documents/in/Anti-Bacterial_Agents"},{"id":408997,"name":"Colistin","url":"https://www.academia.edu/Documents/in/Colistin"},{"id":419370,"name":"Swine","url":"https://www.academia.edu/Documents/in/Swine"},{"id":479537,"name":"Bacterial growth","url":"https://www.academia.edu/Documents/in/Bacterial_growth"},{"id":537759,"name":"Gastrointestinal Tract","url":"https://www.academia.edu/Documents/in/Gastrointestinal_Tract"},{"id":561014,"name":"Microbial Sensitivity Tests","url":"https://www.academia.edu/Documents/in/Microbial_Sensitivity_Tests"},{"id":644860,"name":"Veterinary Sciences","url":"https://www.academia.edu/Documents/in/Veterinary_Sciences"},{"id":770580,"name":"Swine Diseases","url":"https://www.academia.edu/Documents/in/Swine_Diseases"},{"id":989646,"name":"Aqueous Solution","url":"https://www.academia.edu/Documents/in/Aqueous_Solution"},{"id":1309706,"name":"Area Under Curve","url":"https://www.academia.edu/Documents/in/Area_Under_Curve"},{"id":1692059,"name":"Minimum inhibitory concentration","url":"https://www.academia.edu/Documents/in/Minimum_inhibitory_concentration"},{"id":2430299,"name":"Gastrointestinal Diseases","url":"https://www.academia.edu/Documents/in/Gastrointestinal_Diseases"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66069550"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66069550/Salivary_fluoride_concentrations_following_applications_of_bioadhesive_tablets_and_mouthrinses"><img alt="Research paper thumbnail of Salivary fluoride concentrations following applications of bioadhesive tablets and mouthrinses" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66069550/Salivary_fluoride_concentrations_following_applications_of_bioadhesive_tablets_and_mouthrinses">Salivary fluoride concentrations following applications of bioadhesive tablets and mouthrinses</a></div><div class="wp-workCard_item"><span>European Journal of Pharmaceutics and Biopharmaceutics</span><span>, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Presence of elevated fluoride concentration in saliva is important for the prevention of caries. ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Presence of elevated fluoride concentration in saliva is important for the prevention of caries. In the present study, we developed an intra-oral bioadhesive tablet aimed at delivering F(-) in the mouth over a prolonged period of time. Various tablet formulations were tested in vivo for their tolerance and adhesiveness. Two formulations were selected for further studies on salivary fluoride clearance. For comparison, mouthrinses with increasing F(-) concentrations were also examined. Results indicate that a bioadhesive tablet located on the upper gingiva is able to sustain salivary F(-) concentrations for about 10h without major side effects. Mouthrinses with high F(-) concentration were able to prolong salivary fluoride retention for more than 6h.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66069550"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66069550"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66069550; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66069550]").text(description); $(".js-view-count[data-work-id=66069550]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66069550; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='66069550']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 66069550, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=66069550]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":66069550,"title":"Salivary fluoride concentrations following applications of bioadhesive tablets and mouthrinses","translated_title":"","metadata":{"abstract":"Presence of elevated fluoride concentration in saliva is important for the prevention of caries. In the present study, we developed an intra-oral bioadhesive tablet aimed at delivering F(-) in the mouth over a prolonged period of time. Various tablet formulations were tested in vivo for their tolerance and adhesiveness. Two formulations were selected for further studies on salivary fluoride clearance. For comparison, mouthrinses with increasing F(-) concentrations were also examined. Results indicate that a bioadhesive tablet located on the upper gingiva is able to sustain salivary F(-) concentrations for about 10h without major side effects. Mouthrinses with high F(-) concentration were able to prolong salivary fluoride retention for more than 6h.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2000,"errors":{}},"publication_name":"European Journal of Pharmaceutics and Biopharmaceutics"},"translated_abstract":"Presence of elevated fluoride concentration in saliva is important for the prevention of caries. In the present study, we developed an intra-oral bioadhesive tablet aimed at delivering F(-) in the mouth over a prolonged period of time. Various tablet formulations were tested in vivo for their tolerance and adhesiveness. Two formulations were selected for further studies on salivary fluoride clearance. For comparison, mouthrinses with increasing F(-) concentrations were also examined. Results indicate that a bioadhesive tablet located on the upper gingiva is able to sustain salivary F(-) concentrations for about 10h without major side effects. Mouthrinses with high F(-) concentration were able to prolong salivary fluoride retention for more than 6h.","internal_url":"https://www.academia.edu/66069550/Salivary_fluoride_concentrations_following_applications_of_bioadhesive_tablets_and_mouthrinses","translated_internal_url":"","created_at":"2021-12-26T23:43:31.773-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":36529724,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Salivary_fluoride_concentrations_following_applications_of_bioadhesive_tablets_and_mouthrinses","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":36529724,"first_name":"V.","middle_initials":null,"last_name":"Kaltsatos","page_name":"VKaltsatos","domain_name":"independent","created_at":"2015-10-19T08:34:35.427-07:00","display_name":"V. Kaltsatos","url":"https://independent.academia.edu/VKaltsatos"},"attachments":[],"research_interests":[{"id":11257,"name":"Drug delivery","url":"https://www.academia.edu/Documents/in/Drug_delivery"},{"id":105826,"name":"Dental Caries","url":"https://www.academia.edu/Documents/in/Dental_Caries"},{"id":146936,"name":"Fluorides","url":"https://www.academia.edu/Documents/in/Fluorides"},{"id":344106,"name":"Saliva","url":"https://www.academia.edu/Documents/in/Saliva"},{"id":375098,"name":"Gingiva","url":"https://www.academia.edu/Documents/in/Gingiva"},{"id":421276,"name":"Delivery System","url":"https://www.academia.edu/Documents/in/Delivery_System"},{"id":469032,"name":"Mouthwashes","url":"https://www.academia.edu/Documents/in/Mouthwashes"},{"id":469096,"name":"Cariostatic Agents","url":"https://www.academia.edu/Documents/in/Cariostatic_Agents"},{"id":476883,"name":"Tablets","url":"https://www.academia.edu/Documents/in/Tablets"},{"id":687524,"name":"Adhesives","url":"https://www.academia.edu/Documents/in/Adhesives"},{"id":698785,"name":"Side Effect","url":"https://www.academia.edu/Documents/in/Side_Effect"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "07d2c3118f6f842b86fdde0140ef91dd0102c1ee9f00affe8f400bba5dceabce", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="/A+qm+MNuW87TG/iEX0aiulGqWybrySQw1RT1L54QPpTwguVjKiToxYcEBKooZRSM9rqHtj/DXAXfCtCMtgQiA==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://independent.academia.edu/VKaltsatos" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="5VJ4uhamjQNxL/ydlQ3OFiwIFsPamHkAnXk1qQkthONKn9m0eQOnz1x/g20s0UDO9pRVsZnIUOBJUU0/hY3UkQ==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>