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li{display:table-cell;float:none!important;width:10%;padding:0 15px;border-right:1px solid rgba(0,0,0,0.05)}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:last-child{border-right-width:0}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li.hide-border{border-right-width:0}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li a{border-bottom-width:0;padding:9px 15px;line-height:120%}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title{font-weight:700}.rtl .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child{border-right-width:0}.rtl .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:last-child{border-right-width:1px}body.header-shop #Top_bar #menu{display:flex!important;background-color:transparent}.header-shop #Top_bar.is-sticky .top_bar_row_second{display:none}.header-plain:not(.menuo-right) #Header .top_bar_left{width:auto!important}.header-stack.header-center #Top_bar #menu{display:inline-block!important}.header-simple #Top_bar #menu{display:none;height:auto;width:300px;bottom:auto;top:100%;right:1px;position:absolute;margin:0}.header-simple #Header a.responsive-menu-toggle{display:block;right:10px}.header-simple #Top_bar #menu > ul{width:100%;float:left}.header-simple #Top_bar #menu ul li{width:100%;padding-bottom:0;border-right:0;position:relative}.header-simple #Top_bar #menu ul li a{padding:0 20px;margin:0;display:block;height:auto;line-height:normal;border:none}.header-simple #Top_bar #menu ul li a:not(.menu-toggle):after{display:none}.header-simple #Top_bar #menu ul li a span{border:none;line-height:44px;display:inline;padding:0}.header-simple #Top_bar #menu ul li.submenu .menu-toggle{display:block;position:absolute;right:0;top:0;width:44px;height:44px;line-height:44px;font-size:30px;font-weight:300;text-align:center;cursor:pointer;color:#444;opacity:0.33;transform:unset}.header-simple #Top_bar #menu ul li.submenu .menu-toggle:after{content:"+";position:static}.header-simple #Top_bar #menu ul li.hover > .menu-toggle:after{content:"-"}.header-simple #Top_bar #menu ul li.hover a{border-bottom:0}.header-simple #Top_bar #menu ul.mfn-megamenu li .menu-toggle{display:none}.header-simple #Top_bar #menu ul li ul{position:relative!important;left:0!important;top:0;padding:0;margin:0!important;width:auto!important;background-image:none}.header-simple #Top_bar #menu ul li ul li{width:100%!important;display:block;padding:0}.header-simple #Top_bar #menu ul li ul li a{padding:0 20px 0 30px}.header-simple #Top_bar #menu ul li ul li a .menu-arrow{display:none}.header-simple #Top_bar #menu ul li ul li a span{padding:0}.header-simple #Top_bar #menu ul li ul li a span:after{display:none!important}.header-simple #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title{text-transform:uppercase;font-weight:400}.header-simple #Top_bar .menu > li > ul.mfn-megamenu > li > ul{display:block!important;position:inherit;left:auto;top:auto}.header-simple #Top_bar #menu ul li ul li ul{border-left:0!important;padding:0;top:0}.header-simple #Top_bar #menu ul li ul li ul li a{padding:0 20px 0 40px}.rtl.header-simple #Top_bar #menu{left:1px;right:auto}.rtl.header-simple #Top_bar a.responsive-menu-toggle{left:10px;right:auto}.rtl.header-simple #Top_bar #menu ul li.submenu .menu-toggle{left:0;right:auto}.rtl.header-simple #Top_bar #menu ul li ul{left:auto!important;right:0!important}.rtl.header-simple #Top_bar #menu ul li ul li a{padding:0 30px 0 20px}.rtl.header-simple #Top_bar #menu ul li ul li ul li a{padding:0 40px 0 20px}.menu-highlight #Top_bar .menu > li{margin:0 2px}.menu-highlight:not(.header-creative) #Top_bar .menu > li > a{padding:0;-webkit-border-radius:5px;border-radius:5px}.menu-highlight #Top_bar .menu > li > a:after{display:none}.menu-highlight #Top_bar .menu > li > a span:not(.description){line-height:50px}.menu-highlight #Top_bar .menu > li > a span.description{display:none}.menu-highlight.header-stack #Top_bar .menu > li > a{margin:10px 0!important}.menu-highlight.header-stack #Top_bar .menu > li > a span:not(.description){line-height:40px}.menu-highlight.header-simple #Top_bar #menu ul li,.menu-highlight.header-creative #Top_bar #menu ul li{margin:0}.menu-highlight.header-simple #Top_bar #menu ul li > a,.menu-highlight.header-creative #Top_bar #menu ul li > a{-webkit-border-radius:0;border-radius:0}.menu-highlight:not(.header-fixed):not(.header-simple) #Top_bar.is-sticky .menu > li > a{margin:10px 0!important;padding:5px 0!important}.menu-highlight:not(.header-fixed):not(.header-simple) #Top_bar.is-sticky .menu > li > a span{line-height:30px!important}.header-modern.menu-highlight.menuo-right .menu_wrapper{margin-right:20px}.menu-line-below #Top_bar .menu > li > a:not(.menu-toggle):after{top:auto;bottom:-4px}.menu-line-below #Top_bar.is-sticky .menu > li > a:not(.menu-toggle):after{top:auto;bottom:-4px}.menu-line-below-80 #Top_bar:not(.is-sticky) .menu > li > a:not(.menu-toggle):after{height:4px;left:10%;top:50%;margin-top:20px;width:80%}.menu-line-below-80-1 #Top_bar:not(.is-sticky) .menu > li > a:not(.menu-toggle):after{height:1px;left:10%;top:50%;margin-top:20px;width:80%}.menu-link-color #Top_bar .menu > li > a:not(.menu-toggle):after{display:none!important}.menu-arrow-top #Top_bar .menu > li > a:after{background:none repeat scroll 0 0 rgba(0,0,0,0)!important;border-color:#ccc transparent transparent;border-style:solid;border-width:7px 7px 0;display:block;height:0;left:50%;margin-left:-7px;top:0!important;width:0}.menu-arrow-top #Top_bar.is-sticky .menu > li > a:after{top:0!important}.menu-arrow-bottom #Top_bar .menu > li > a:after{background:none!important;border-color:transparent transparent #ccc;border-style:solid;border-width:0 7px 7px;display:block;height:0;left:50%;margin-left:-7px;top:auto;bottom:0;width:0}.menu-arrow-bottom #Top_bar.is-sticky .menu > li > a:after{top:auto;bottom:0}.menuo-no-borders #Top_bar .menu > li > a span{border-width:0!important}.menuo-no-borders #Header_creative #Top_bar .menu > li > a span{border-bottom-width:0}.menuo-no-borders.header-plain #Top_bar a#header_cart,.menuo-no-borders.header-plain #Top_bar a#search_button,.menuo-no-borders.header-plain #Top_bar .wpml-languages,.menuo-no-borders.header-plain #Top_bar a.action_button{border-width:0}.menuo-right #Top_bar .menu_wrapper{float:right}.menuo-right.header-stack:not(.header-center) #Top_bar .menu_wrapper{margin-right:150px}body.header-creative{padding-left:50px}body.header-creative.header-open{padding-left:250px}body.error404,body.under-construction,body.template-blank,body.under-construction.header-rtl.header-creative.header-open{padding-left:0!important;padding-right:0!important}.header-creative.footer-fixed #Footer,.header-creative.footer-sliding #Footer,.header-creative.footer-stick #Footer.is-sticky{box-sizing:border-box;padding-left:50px}.header-open.footer-fixed #Footer,.header-open.footer-sliding #Footer,.header-creative.footer-stick #Footer.is-sticky{padding-left:250px}.header-rtl.header-creative.footer-fixed #Footer,.header-rtl.header-creative.footer-sliding #Footer,.header-rtl.header-creative.footer-stick #Footer.is-sticky{padding-left:0;padding-right:50px}.header-rtl.header-open.footer-fixed #Footer,.header-rtl.header-open.footer-sliding #Footer,.header-rtl.header-creative.footer-stick #Footer.is-sticky{padding-right:250px}#Header_creative{background-color:#fff;position:fixed;width:250px;height:100%;left:-200px;top:0;z-index:9002;-webkit-box-shadow:2px 0 4px 2px rgba(0,0,0,.15);box-shadow:2px 0 4px 2px rgba(0,0,0,.15)}#Header_creative .container{width:100%}#Header_creative .creative-wrapper{opacity:0;margin-right:50px}#Header_creative a.creative-menu-toggle{display:block;width:34px;height:34px;line-height:34px;font-size:22px;text-align:center;position:absolute;top:10px;right:8px;border-radius:3px}.admin-bar #Header_creative a.creative-menu-toggle{top:42px}#Header_creative #Top_bar{position:static;width:100%}#Header_creative #Top_bar .top_bar_left{width:100%!important;float:none}#Header_creative #Top_bar .logo{float:none;text-align:center;margin:15px 0}#Header_creative #Top_bar #menu{background-color:transparent}#Header_creative #Top_bar .menu_wrapper{float:none;margin:0 0 30px}#Header_creative #Top_bar .menu > li{width:100%;float:none;position:relative}#Header_creative #Top_bar .menu > li > a{padding:0;text-align:center}#Header_creative #Top_bar .menu > li > a:after{display:none}#Header_creative #Top_bar .menu > li > a span{border-right:0;border-bottom-width:1px;line-height:38px}#Header_creative #Top_bar .menu li ul{left:100%;right:auto;top:0;box-shadow:2px 2px 2px 0 rgba(0,0,0,0.03);-webkit-box-shadow:2px 2px 2px 0 rgba(0,0,0,0.03)}#Header_creative #Top_bar .menu > li > ul.mfn-megamenu{margin:0;width:700px!important}#Header_creative #Top_bar .menu > li > ul.mfn-megamenu > li > ul{left:0}#Header_creative #Top_bar .menu li ul li a{padding-top:9px;padding-bottom:8px}#Header_creative #Top_bar .menu li ul li ul{top:0}#Header_creative #Top_bar .menu > li > a span.description{display:block;font-size:13px;line-height:28px!important;clear:both}.menuo-arrows #Top_bar .menu > li.submenu > a > span:after{content:unset!important}#Header_creative #Top_bar .top_bar_right{width:100%!important;float:left;height:auto;margin-bottom:35px;text-align:center;padding:0 20px;top:0;-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}#Header_creative #Top_bar .top_bar_right:before{content:none}#Header_creative #Top_bar .top_bar_right .top_bar_right_wrapper{flex-wrap:wrap;justify-content:center}#Header_creative #Top_bar .top_bar_right .top-bar-right-icon,#Header_creative #Top_bar .top_bar_right .wpml-languages,#Header_creative #Top_bar .top_bar_right .top-bar-right-button,#Header_creative #Top_bar .top_bar_right .top-bar-right-input{min-height:30px;margin:5px}#Header_creative #Top_bar .search_wrapper{left:100%;top:auto}#Header_creative #Top_bar .banner_wrapper{display:block;text-align:center}#Header_creative #Top_bar .banner_wrapper img{max-width:100%;height:auto;display:inline-block}#Header_creative #Action_bar{display:none;position:absolute;bottom:0;top:auto;clear:both;padding:0 20px;box-sizing:border-box}#Header_creative #Action_bar .contact_details{width:100%;text-align:center;margin-bottom:20px}#Header_creative #Action_bar .contact_details li{padding:0}#Header_creative #Action_bar .social{float:none;text-align:center;padding:5px 0 15px}#Header_creative #Action_bar .social li{margin-bottom:2px}#Header_creative #Action_bar .social-menu{float:none;text-align:center}#Header_creative #Action_bar .social-menu li{border-color:rgba(0,0,0,.1)}#Header_creative .social li a{color:rgba(0,0,0,.5)}#Header_creative .social li a:hover{color:#000}#Header_creative .creative-social{position:absolute;bottom:10px;right:0;width:50px}#Header_creative .creative-social li{display:block;float:none;width:100%;text-align:center;margin-bottom:5px}.header-creative .fixed-nav.fixed-nav-prev{margin-left:50px}.header-creative.header-open .fixed-nav.fixed-nav-prev{margin-left:250px}.menuo-last #Header_creative #Top_bar .menu li.last ul{top:auto;bottom:0}.header-open #Header_creative{left:0}.header-open #Header_creative .creative-wrapper{opacity:1;margin:0!important}.header-open #Header_creative .creative-menu-toggle,.header-open #Header_creative .creative-social{display:none}.header-open #Header_creative #Action_bar{display:block}body.header-rtl.header-creative{padding-left:0;padding-right:50px}.header-rtl #Header_creative{left:auto;right:-200px}.header-rtl #Header_creative .creative-wrapper{margin-left:50px;margin-right:0}.header-rtl #Header_creative a.creative-menu-toggle{left:8px;right:auto}.header-rtl #Header_creative .creative-social{left:0;right:auto}.header-rtl #Footer #back_to_top.sticky{right:125px}.header-rtl #popup_contact{right:70px}.header-rtl #Header_creative #Top_bar .menu li ul{left:auto;right:100%}.header-rtl #Header_creative #Top_bar .search_wrapper{left:auto;right:100%}.header-rtl .fixed-nav.fixed-nav-prev{margin-left:0!important}.header-rtl .fixed-nav.fixed-nav-next{margin-right:50px}body.header-rtl.header-creative.header-open{padding-left:0;padding-right:250px!important}.header-rtl.header-open #Header_creative{left:auto;right:0}.header-rtl.header-open #Footer #back_to_top.sticky{right:325px}.header-rtl.header-open #popup_contact{right:270px}.header-rtl.header-open .fixed-nav.fixed-nav-next{margin-right:250px}#Header_creative.active{left:-1px}.header-rtl #Header_creative.active{left:auto;right:-1px}#Header_creative.active .creative-wrapper{opacity:1;margin:0}.header-creative .vc_row[data-vc-full-width]{padding-left:50px}.header-creative.header-open .vc_row[data-vc-full-width]{padding-left:250px}.header-open .vc_parallax .vc_parallax-inner{left:auto;width:calc(100% - 250px)}.header-open.header-rtl .vc_parallax .vc_parallax-inner{left:0;right:auto}#Header_creative.scroll{height:100%;overflow-y:auto}#Header_creative.scroll:not(.dropdown) .menu li ul{display:none!important}#Header_creative.scroll #Action_bar{position:static}#Header_creative.dropdown{outline:none}#Header_creative.dropdown #Top_bar .menu_wrapper{float:left;width:100%}#Header_creative.dropdown #Top_bar #menu ul li{position:relative;float:left}#Header_creative.dropdown #Top_bar #menu ul li a:not(.menu-toggle):after{display:none}#Header_creative.dropdown #Top_bar #menu ul li a span{line-height:38px;padding:0}#Header_creative.dropdown #Top_bar #menu ul li.submenu .menu-toggle{display:block;position:absolute;right:0;top:0;width:38px;height:38px;line-height:38px;font-size:26px;font-weight:300;text-align:center;cursor:pointer;color:#444;opacity:0.33;z-index:203}#Header_creative.dropdown #Top_bar #menu ul li.submenu .menu-toggle:after{content:"+";position:static}#Header_creative.dropdown #Top_bar #menu ul li.hover > .menu-toggle:after{content:"-"}#Header_creative.dropdown #Top_bar #menu ul.sub-menu li:not(:last-of-type) a{border-bottom:0}#Header_creative.dropdown #Top_bar #menu ul.mfn-megamenu li .menu-toggle{display:none}#Header_creative.dropdown #Top_bar #menu ul li ul{position:relative!important;left:0!important;top:0;padding:0;margin-left:0!important;width:auto!important;background-image:none}#Header_creative.dropdown #Top_bar #menu ul li ul li{width:100%!important}#Header_creative.dropdown #Top_bar #menu ul li ul li a{padding:0 10px;text-align:center}#Header_creative.dropdown #Top_bar #menu ul li ul li a .menu-arrow{display:none}#Header_creative.dropdown #Top_bar #menu ul li ul li a span{padding:0}#Header_creative.dropdown #Top_bar #menu ul li ul li a span:after{display:none!important}#Header_creative.dropdown #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title{text-transform:uppercase;font-weight:400}#Header_creative.dropdown #Top_bar .menu > li > ul.mfn-megamenu > li > ul{display:block!important;position:inherit;left:auto;top:auto}#Header_creative.dropdown #Top_bar #menu ul li ul li ul{border-left:0!important;padding:0;top:0}#Header_creative{transition:left .5s ease-in-out,right .5s ease-in-out}#Header_creative .creative-wrapper{transition:opacity .5s ease-in-out,margin 0s ease-in-out .5s}#Header_creative.active .creative-wrapper{transition:opacity .5s ease-in-out,margin 0s ease-in-out}}@media only screen and (min-width:1240px){#Top_bar.is-sticky{position:fixed!important;width:100%;left:0;top:-60px;height:60px;z-index:701;background:#fff;opacity:.97;-webkit-box-shadow:0 2px 5px 0 rgba(0,0,0,0.1);-moz-box-shadow:0 2px 5px 0 rgba(0,0,0,0.1);box-shadow:0 2px 5px 0 rgba(0,0,0,0.1)}.layout-boxed.header-boxed #Top_bar.is-sticky{left:50%;-webkit-transform:translateX(-50%);transform:translateX(-50%)}#Top_bar.is-sticky .top_bar_left,#Top_bar.is-sticky .top_bar_right,#Top_bar.is-sticky .top_bar_right:before{background:none;box-shadow:unset}#Top_bar.is-sticky .logo{width:auto;margin:0 30px 0 20px;padding:0}#Top_bar.is-sticky #logo,#Top_bar.is-sticky .custom-logo-link{padding:5px 0!important;height:50px!important;line-height:50px!important}.logo-no-sticky-padding #Top_bar.is-sticky #logo{height:60px!important;line-height:60px!important}#Top_bar.is-sticky #logo img.logo-main{display:none}#Top_bar.is-sticky #logo img.logo-sticky{display:inline;max-height:35px}.logo-sticky-width-auto #Top_bar.is-sticky #logo img.logo-sticky{width:auto}#Top_bar.is-sticky .menu_wrapper{clear:none}#Top_bar.is-sticky .menu_wrapper .menu > li > a{padding:15px 0}#Top_bar.is-sticky .menu > li > a,#Top_bar.is-sticky .menu > li > a span{line-height:30px}#Top_bar.is-sticky .menu > li > a:after{top:auto;bottom:-4px}#Top_bar.is-sticky .menu > li > a span.description{display:none}#Top_bar.is-sticky .secondary_menu_wrapper,#Top_bar.is-sticky .banner_wrapper{display:none}.header-overlay #Top_bar.is-sticky{display:none}.sticky-dark #Top_bar.is-sticky,.sticky-dark #Top_bar.is-sticky #menu{background:rgba(0,0,0,.8)}.sticky-dark #Top_bar.is-sticky .menu > li:not(.current-menu-item) > a{color:#fff}.sticky-dark #Top_bar.is-sticky .top_bar_right .top-bar-right-icon{color:rgba(255,255,255,.9)}.sticky-dark #Top_bar.is-sticky .top_bar_right .top-bar-right-icon svg .path{stroke:rgba(255,255,255,.9)}.sticky-dark #Top_bar.is-sticky .wpml-languages a.active,.sticky-dark #Top_bar.is-sticky .wpml-languages ul.wpml-lang-dropdown{background:rgba(0,0,0,0.1);border-color:rgba(0,0,0,0.1)}.sticky-white #Top_bar.is-sticky,.sticky-white #Top_bar.is-sticky #menu{background:rgba(255,255,255,.8)}.sticky-white #Top_bar.is-sticky .menu > li:not(.current-menu-item) > a{color:#222}.sticky-white #Top_bar.is-sticky .top_bar_right .top-bar-right-icon{color:rgba(0,0,0,.8)}.sticky-white #Top_bar.is-sticky .top_bar_right .top-bar-right-icon svg .path{stroke:rgba(0,0,0,.8)}.sticky-white #Top_bar.is-sticky .wpml-languages a.active,.sticky-white #Top_bar.is-sticky .wpml-languages 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a{color:#0095eb}#Action_bar .contact_details a:hover{color:#007cc3}#Action_bar .social li a,#Action_bar .social-menu a{color:#bbbbbb!important}#Action_bar .social li a:hover,#Action_bar .social-menu a:hover{color:#777777!important}} form input.display-none{display:none!important} </style> <link rel='stylesheet' id='style-css' href='https://www.wyatt.com/wp-content/themes/betheme-child/style.css?ver=6.4.5' type='text/css' media='all' /> <style id='mfn-custom-inline-css' type='text/css'> @supports (-ms-ime-align: auto) { } span {font-family:"Open Sans", Arial, Tahoma, sans-serif !important;} @media only screen and (min-width: 1240px) { .header-classic #Header .top_bar_left {width:1306px;} #Top_bar .menu > li > a {padding:15px 5px;} #Top_bar.is-sticky .menu_wrapper .menu > li > a {padding:15px 5px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu{ padding-top:0px; padding-bottom:0px; width:92.5%!important; margin:0px 3%;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu .container {display:block;} /** Added 121024 **/ h1 { line-height: 44px !important; } .h2-underline {border-bottom: thick solid #ffb600; padding-bottom: 15px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu::before {content:' '; background:#fff; position:absolute; width:100vw; height:100%; margin-left: -50vw; left: 50%; } .mm-vertical #Top_bar .menu > li > .menu-overlap {z-index:1;background:rgba(0,0,0,0.4); position:absolute; width:100vw; height:100vh; margin-left: -50vw; left: 50%; cursor:hand; cursor:pointer;} .mm-vertical #Top_bar .menu > li.not-active a{color:#444444;} .mm-vertical #Top_bar .menu > li.not-active a::after {opacity:0;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title, .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title:hover {padding:5px 0px; background:transparent; color:#444444; text-transform:unset;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title:hover span {text-decoration:none ;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu ul {background:transparent; } .mm-vertical #Top_bar .menu > li >ul.mfn-megamenu ul a {color:#007dc5; } .mm-vertical #Top_bar .menu > li >ul.mfn-megamenu ul a:hover {background:transparent;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li a {padding:5px 0px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li a:hover {text-decoration:underline;} .mm-vertical #Top_bar .menu > li > ul {padding:20px 20px 20px 2px;} .mm-vertical #Top_bar .menu > li > ul a {padding:5px; border:0px; color:#007dc5;} .mm-vertical #Top_bar .menu > li > ul a:hover {background:transparent; } .mm-vertical #Top_bar .menu > li > ul a:hover span {text-decoration:underline ;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li {padding-top:20px; padding-bottom:25px; border-right: 0px solid rgba(0, 0, 0, 0.05);} /*for parent title in sbmenu*/ .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child {display:none; width:auto; padding-bottom:0px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child h3 {padding-top:20px; line-height:30px; border-bottom:1px solid #ccc; font-weight:600;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child h3 a{color:#444444;} /*for contact submenu*/ .mm-vertical #Top_bar .menu > li#menu-item-2437 li.mfn-megamenu-cols-2 li {} /*menu button css*/ .mm-vertical #Top_bar .menu > li#menu-item-5221 a span {background:#007dc5; color:#fff; border-radius:6px; line-height:40px; margin-top:8px; margin-left:20px;} .mm-vertical #Top_bar .menu > li#menu-item-5221 a:after {display:none;} #Top_bar.is-sticky .menu > li#menu-item-5221 > a, #Top_bar.is-sticky .menu > li#menu-item-5221 > a span {line-height:30px; margin-top:0px;} .mm-vertical #Top_bar li#menu-item-6152 a {color:#000 !important; padding-top:0px !important; white-space:nowrap; color: #007dc5 !important; font-weight: 400;} /*set width of menu item*/ .mm-vertical #Top_bar li#menu-item-2341 {width:343px; padding-left: 80px;} .mm-vertical #Top_bar li#menu-item-2348 {width:278px;} .mm-vertical #Top_bar li#menu-item-2355 {width:288px;} .mm-vertical #Top_bar li#menu-item-2363 {width:240px;} .mm-vertical #Top_bar li#menu-item-2369 {width:541px; padding-left:70px;} .mm-vertical #Top_bar li#menu-item-2379 {width:340px;} .mm-vertical #Top_bar li#menu-item-2384 {width:280px;} .mm-vertical #Top_bar li#menu-item-2391 {width:350px; padding-left:80px;} .mm-vertical #Top_bar li#menu-item-2395 {width:310px;} .mm-vertical #Top_bar li#menu-item-2403 {width:310px;} .mm-vertical #Top_bar li#menu-item-2408 {width:210px;} .mm-vertical #Top_bar li#menu-item-5918 {width:487px; padding-left:115px;} .mm-vertical #Top_bar li#menu-item-5919 {width:387px;} .mm-vertical #Top_bar li#menu-item-5920 {width:280px;} .mm-vertical #Top_bar li#menu-item-2427 {width:700px; padding-left:300px;} .mm-vertical #Top_bar li#menu-item-5235 {width:487px; padding-left:115px;} .mm-vertical #Top_bar li#menu-item-5765 {width:310px;} .mm-vertical #Top_bar li#menu-item-26131 {width:387px;} .mm-vertical #Top_bar li#menu-item-15082 {width:700px; padding-left:300px;} .mm-vertical #Top_bar li#menu-item-15044 {width:397px;} } @media only screen and (max-width: 1239px) { #menu > ul > li > a, a.action_button, #overlay-menu ul li a { font-size: 15px; font-weight: 400; letter-spacing: 1px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child {display:none; width:auto; padding-bottom:0px;} .mm-vertical #Top_bar #menu ul li ul li a {font-size:16px;} .mm-vertical #Top_bar #menu ul li ul li ul li a {font-size:15px;} } /* Header */ .header-classic #Top_bar { border-bottom: 0px solid #e1e1e1;} .header-classic:not(.home) #Content { border-top: 0px solid #e1e1e1; } .header-classic.home .mfn-rev-slider { border-top: 1px solid #e1e1e1; } /*Action Bar*/ #Action_bar a {color:#fff;} /* Widget */ .widget-area:before { display: none; } .aside_left .widget-area { border: 0; } /* Icon box */ .icon_box.has_border { background: #fff; border: 1px solid #e1e1e1; padding: 40px 10%; } .icon_box.no_border {background: #fff; border:0px; padding: 40px 10%;} .icon_box.has_border:after {border:0px} /* Offer box */ .offer_box { background-color: #252525; padding: 20px 20px 5px; text-align: center; } .offer_box .offer_box_list { border-width: 1px 1px 0 1px; border-style: solid; border-color: #929292; font-weight: 700; font-size: 16px; letter-spacing: 2px; margin-bottom: 20px; } .offer_box .offer_box_list a { display: block; color: #fff; border-bottom: 1px solid #929292; padding: 18px 15px; word-wrap: break-word; } /* Footer */ /*#Footer { border-top: 1px solid #e1e1e1; }*/ #Footer .widget > h4 { font-size: 18px; font-weight: 300; margin-bottom: 20px; } #Footer .footer_copy { background: #465158; border-top: 0; } .before-footer {background: #f9f9f9;} #Footer .footer_copy .social { display: none; } /**/ .top-widgets-container {float:right} .top-widgets-container .widget {padding-bottom:0px; margin-bottom:0px; float:right;margin-top:0px;} .top-widgets-container .widget ul.menu{list-style:none; padding:0px;} .top-widgets-container .widget ul.menu li {float:left; padding:12px 0px;} .top-widgets-container .widget ul.menu li a{padding:0px 20px; border-right:1px solid #ccc; line-height:15px;} .top-widgets-container .widget ul.menu li:last-child a{border-right:0px;} .top-widgets-container .widget_search .icon-search-fine {font-size:24px; line-height:40px;} .top-widgets-container .widget_search input[type="text"] {width:82%; float:right; padding:5px 10px 5px 5px; border:0px; margin-top:7px; height:30px;min-height:30px;} #menu-top-navigation .cart a {padding:0px 20px; } #menu-top-navigation .cart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; padding-right:10px; font-size:26px; color:#fff; text-indent:0;} .mobilecart {display:none; width:30px; float:right; margin-top:11px;} .mobilecart a { padding:0px; border:0px;} .mobilecart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; left:15px; font-size:26px; color:#fff; text-indent:0;} @media only screen and (min-width:320px) and (max-width:767px) { .top-widgets-container .widget {float:none;} .top-widgets-container .widget.widget_nav_menu {max-width:245px; margin:0px auto; clear:both;} .top-widgets-container .widget ul.menu li a {padding:0px 15px;} #menu-top-navigation .cart.menu-item-2449 {display:none;} #menu-top-navigation .cart a {padding:0px 10px;} .widget_archive ul li:after, .widget_nav_menu ul li:after {display:none;} .widget:after {display:none;} .top-widgets-container {float:none; margin:0px auto;} .top-widgets-container .widget_search input[type="text"] {width:80%;} .mobilecart {display:block;} .top-widgets-container .widget_search {width:254px; overflow:hidden;padding-bottom:20px; margin:0px auto;} .top-widgets-container .widget_search .searchform{width:210px; float:left;} } .icon-100 .image_wrapper img {width:150px; height:150px;} .down-heading, .heading {padding-left:17px;} @media only screen and (min-width:320px) and (max-width:767px) { .down-heading, .heading {padding:0px; text-align:center;} } .ui-tabs .ui-tabs-nav li {border-width:0px;} .page-id-2602 .ui-tabs .ui-tabs-nav li a {padding:14px 28px !important;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li {border:0px; padding:5px 0px;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li a {background-image:none; font-size:100%; color:#2991d6; padding:5px 10px 5px 20px !important;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li a:hover {text-decoration:underline;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a {color:#000; border-left:3px solid #2991d6; border-radius:0px !important; padding:5px 10px 5px 17px !important;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav {width:23%; border:0px !important;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-panel {width:76.7%; border:0px !important; padding-top:5px;} @media only screen and (min-width:768px) and (max-width:1239px) { .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li a {font-size:100%;} } @media only screen and (min-width:320px) and (max-width:767px) { .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav {width:100%;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-panel {width:100%; padding-top:15px;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li a {-webkit-box-shadow:none;-moz-box-shadow:none;box-shadow:none;} } .ui-tabs .ui-tabs-nav li h3 {margin:0px; padding:0px;} .ui-tabs .ui-tabs-nav li h3 a { text-decoration: none; display: block; padding: 14px 30px !important; font-size: 100%; font-weight:initial; } .ui-tabs .ui-tabs-panel .icon_box {padding-bottom:2px;} .ui-tabs .ui-tabs-panel .column.one-fourth {width:25%;} .ui-tabs .ui-tabs-panel .column.one-second, .ui-tabs .ui-tabs-panel .column.one-fourth, .ui-tabs .ui-tabs-panel .column.one-third, .ui-tabs .ui-tabs-panel .column.two-third{margin-left:0px; margin-right:0px;} @media only screen and (min-width: 960px) and (max-width: 1239px) { .ui-tabs .ui-tabs-nav li h3 a {font-size:100%; padding:10px 20px !important;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .ui-tabs .ui-tabs-nav li h3 a {font-size:100%; padding:5px 10px !important;} } /* Make Nav Subheadings unclickable */ .unclickable > a:hover { cursor: default;} .wp-caption-text { background: transparent; color: #075c97; font-size:90%;} .ls-wrapper h3 a {color: #075c97;} .column_sidebar_widget {float:none;} /*app notes*/ ul.clients.appnotes .client_wrapper {text-align:left; height:auto !important; line-height:auto !important; overflow:hidden;} ul.clients.appnotes li:nth-child(2n+1) {clear:both;} ul.clients.appnotes .client_wrapper img { position:relative; left:auto !important; top: auto !important; float:left; -webkit-transform: none!important; -moz-transform: none!important; transform: none!important; padding-right:20px; width:auto!important; } ul.clients.appnotes .client_wrapper h3 { line-height:20px; font-size:16px; letter-spacing:1px; padding-top:10px;} ul.clients.appnotes .client_wrapper a:hover {text-decoration:none;} @media only screen and (max-width: 640px) { ul.clients.appnotes li {width:100% !important; clear:both;} } .pager {padding-top:20px;} .pager .page-numbers {border:1px solid #ccc; padding:3px 5px;} .pager .prev.page-numbers, .pager .next.page-numbers {border:0px;} .alignleft {margin:3px 10px 10px 0px;} dl {clear:both;} .team.team_vertical img.scale-with-grid {width:100%;} .column_placeholder {margin-bottom:0px;} .icon-height img{max-height:50px;} .single .post-header {margin-left:0px; margin-right:0px;} .single .section-post-header .single-photo-wrapper.image {display:none;} .widget_mfn_menu ul li.menu-item-has-children > a::after {content: '\e868'; font-family: "mfn-icons"; right:2px; position:absolute; width:20px; height:15px; color:#ccc; } table th ul, table td ul {list-style-position:inside !important;} .sticky-white #Top_bar.is-sticky, .sticky-white #Top_bar.is-sticky #menu, #Top_bar.is-sticky {background:#fff; opacity:1;} /*Webinars latest posts*/ .parent-pageid-3663 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .parent-pageid-3663 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .parent-pageid-3663 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .parent-pageid-3663 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .parent-pageid-3663 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .parent-pageid-3663 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .parent-pageid-3663 .Latest_news ul li.category-webinars .desc h5 a{color:#007dc5;} .parent-pageid-3663 .Latest_news ul li .desc_footer .date {display:none;} .parent-pageid-3663 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .parent-pageid-3663 .Latest_news ul li .desc_footer .post-comments {display:none;} .parent-pageid-3663 .Latest_news ul li .desc_footer .button-love {display:none;} .parent-pageid-3663 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .parent-pageid-3663 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Upcoming Live Webinars*/ .page-id-2653 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .page-id-2653 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .page-id-2653 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .page-id-2653 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .page-id-2653 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .page-id-2653 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .page-id-2653 .Latest_news ul li.category-webinars .desc h5 a{color:#007dc5;} .page-id-2653 .Latest_news ul li .desc_footer .date {display:none;} .page-id-2653 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .page-id-2653 .Latest_news ul li .desc_footer .post-comments {display:none;} .page-id-2653 .Latest_news ul li .desc_footer .button-love {display:none;} .page-id-2653 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .page-id-2653 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Newsletter Archive*/ .page-id-3661 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .page-id-3661 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .page-id-3661 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .page-id-3661 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .page-id-3661 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .page-id-3661 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .page-id-3661 .Latest_news ul li.category-newsletter-archive .desc h5 a{color:#007dc5;} .page-id-3661 .Latest_news ul li .desc_footer .date {display:none;} .page-id-3661 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .page-id-3661 .Latest_news ul li .desc_footer .post-comments {display:none;} .page-id-3661 .Latest_news ul li .desc_footer .button-love {display:none;} .page-id-3661 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .page-id-3661 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Ask the Expert*/ .page-id-5348 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .page-id-5348 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .page-id-5348 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .page-id-5348 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .page-id-5348 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .page-id-5348 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .page-id-5348 .Latest_news ul li .desc h5{margin-bottom:0px;} .page-id-5348 .Latest_news ul li.category-ask-the-expert .desc h5 a{color:#007dc5;} .page-id-5348 .Latest_news ul li .desc_footer {display:none;} .page-id-5348 .Latest_news ul li .desc_footer .date {display:none;} .page-id-5348 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .page-id-5348 .Latest_news ul li .desc_footer .post-comments {display:none;} .page-id-5348 .Latest_news ul li .desc_footer .button-love {display:none;} .page-id-5348 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .page-id-5348 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; font-weight:normal; line-height:20px;} /*accordion title as h3*/ .accordion .question .title h3 {margin-bottom:0px; } .accordion .question.active .title h3{color:#2991d6} /*column padding*/ .column, .columns {margin:0px 10px 40px;} .accordion .answer .one-second.column {width:47%;} .wrap .one-second.column {width:47%;} /*.column_column ul li {margin-bottom:2px;}*/ .single .post-header {margin-bottom:10px;} /* Appnote seach box*/ .widget_appnote_search_widget {clear:both; display:block; overflow:hidden;} .widget_appnote_search_widget .widget-title {display:inline-block; float:left; margin-right:15px; margin-top:5px;} .widget_appnote_search_widget .searchform {display:inline-block; float:left;} .widget_appnote_search_widget .searchform input[type=text] {float:left; margin:0px; min-width:350px; padding:7px 10px;} .widget_appnote_search_widget .searchform input[type=submit] {background:#0065a4; margin:0px; margin-left:15px; padding:8px 20px;} @media only screen and (min-width: 320px) and (max-width: 650px) { .widget_appnote_search_widget .searchform input[type=text] {min-width:240px;} } @media only screen and (min-width: 320px) and (max-width: 519px) { .widget_appnote_search_widget .searchform input[type=submit] {margin:0px; margin-top:15px;} } /*flat box*/ .flat_box .photo_wrapper .icon {display:none;} .flat_box .photo_wrapper img.photo {transform: translateX(0px)} .flat_box .desc_wrapper {margin-left:0px;} /*center images at user profile*/ .page-id-2504 .image_frame .image_wrapper {text-align:center} .page-id-2504.if-overlay .image_frame:hover .image_wrapper img, .page-id-2504.if-overlay .image_frame.hover .image_wrapper img {transform: scale(1);} .if-overlay .image_frame .image_wrapper .image_links {display:none;} /* Changes for ClickDimensions submit button */ a.button_theme, a.tp-button.button_theme, button, input[type="submit"], input[type="reset"], input[type="button"] { background-color: #0065a4 !important; color: #ffffff !important; font-family: inherit !important; /*padding:0px;*/ } /*isotope wrapper*/ .blog_wrapper.isotope_wrapper .post-item .post-footer {background:none;} .blog_wrapper.isotope_wrapper .post-item .post-footer .post-links{border:0px;} .blog_wrapper.isotope_wrapper .grid .post-photo-wrapper {border:0px;} /* product page*/ .page-id-2582 .ui-tabs-panel .team.team_vertical .image_frame {border:0px;} .page-id-2582 .ui-tabs-panel .team.team_vertical hr.hr_color {background:none;} .page-id-2582.if-overlay .ui-tabs-panel .team.team_vertical .image_frame:hover .image_wrapper img, .page-id-2582.if-overlay .ui-tabs-panel .team.team_vertical .image_frame.hover .image_wrapper img {-webkit-transform: scale(1); -moz-transform: scale(1); -o-transform: scale(1); transform: scale(1); } .page-id-2582 .ui-tabs-panel .one-third.column:nth-child(4n-3) {margin-left:10px; margin-right:17px; } .page-id-2582 .ui-tabs-panel .one-third.column:nth-child(4n-2) {margin-left:18px; margin-right:17px; } .page-id-2582 .ui-tabs-panel .one-third.column:nth-child(4n-1) {margin-left:18px; margin-right:10px; } .page-id-2582 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:65px; margin-right:52px; } .page-id-2582 .ui-tabs-panel .one-second.column:nth-child(even) {margin-left:53px; margin-right:65px; } @media only screen and (min-width: 1301px) { .page-id-2582 .ui-tabs-panel .one-third.column {width:30.9%;} .page-id-2582 .ui-tabs-panel .one-second.column {width:40.2%;} } @media only screen and (min-width: 1240px) and (max-width: 1300px) { .page-id-2582 .ui-tabs-panel .one-third.column {width:30.7%;} .page-id-2582 .ui-tabs-panel .one-second.column {width:47.6%;} } @media only screen and (min-width: 960px) and (max-width: 1239px) { .page-id-2582 .ui-tabs-panel .one-third.column {width:29.9%;} .page-id-2582 .ui-tabs-panel .one-second.column {width:36.6%;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .page-id-2582 .ui-tabs-panel .one-third.column {width:28.7%;} .page-id-2582 .ui-tabs-panel .one-second.column {width:38.9%;} } @media only screen and (min-width: 320px) and (max-width: 767px) { .page-id-2582 .ui-tabs-panel .one-third.column {margin-left:0px; margin-right:0px;} .page-id-2582 .ui-tabs-panel .one-second.column:nth-child(even), .page-id-2582 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:0px; margin-right:0px;} } .uk-margin-small-right {vertical-align:middle; margin-top:-2px;} .page-id-2647 .ui-tabs .ui-tabs-panel .column.one-second {margin-bottom:0px;} .page-id-3641 .blog_wrapper .classic .post-photo-wrapper {border-color:transparent;} @media only screen and (min-width: 960px) { .page-id-3641 .blog_wrapper .classic .post-photo-wrapper {width:12%;} .page-id-3641 .blog_wrapper .classic .post-desc-wrapper {width:88%;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .page-id-3641 .blog_wrapper .classic .post-photo-wrapper { width:25%} .page-id-3641 .blog_wrapper .classic .post-desc-wrapper {width:75%;} } @media only screen and (min-width: 768px) { .page-id-2640 .column.column_pricing_item {margin:0px 1% 40px;} } /* contact form 7 submit button*/ .wpcf7-form-control.wpcf7-submit {padding:10px 30px;} .wpcf7 .red {color:#990000;} .wpcf7 span.wpcf7-list-item {display:block; margin:0px;} .wpcf7 label {font-weight:400;} #lostusername {border:1px solid #ddd; padding:30px 20px 0px;} #lostusername .input {width:100%;} #lostusername .button {padding:10px 20px;} .ur-frontend-form button[type="submit"], .ur-frontend-form input[type="submit"] {float:none;} .page-id-2690.if-overlay .image_frame:hover .image_wrapper img, .page-id-2690.if-overlay .image_frame.hover .image_wrapper img {transform: scale(1);} .page-id-2690 .team .desc_wrapper hr {display:none;} .page-id-2690 .ui-tabs .ui-tabs-panel .column.one-second, .page-id-2690 .ui-tabs .ui-tabs-panel .column.one-fourth, .page-id-2690 .ui-tabs .ui-tabs-panel .column.one-third, .page-id-2690 .ui-tabs .ui-tabs-panel .column.two-third {margin-left:10px; margin-right:10px;} .page-id-2690 .ui-tabs .ui-tabs-panel .column.one-fourth {width:23.4%;} /* webinars seach box*/ .widget_webinars_search_widget {clear:both; display:block; overflow:hidden;} .widget_webinars_search_widget .widget-title {display:inline-block; float:left; margin-right:15px; margin-top:5px;} .widget_webinars_search_widget .searchform {display:inline-block; float:left;} .widget_webinars_search_widget .searchform input[type=text] {float:left; margin:0px; min-width:350px; padding:7px 10px;} .widget_webinars_search_widget .searchform input[type=submit] {background:#0065a4; margin:0px; margin-left:15px; padding:8px 20px;} @media only screen and (min-width: 320px) and (max-width: 650px) { .widget_webinars_search_widget .searchform input[type=text] {min-width:240px;} } @media only screen and (min-width: 320px) and (max-width: 519px) { .widget_webinars_search_widget .searchform input[type=submit] {margin:0px; margin-top:15px;} } /*Recent Webinars nav issue fix*/ .page-id-3665 li#menu-item-2421.current-menu-ancestor:not(.hover) a {color:#000000;} .page-id-3665 li#menu-item-2421.current-menu-ancestor:not(.hover) a:after {display:none;} /*login-in nav issue fix*/ .page-id-5451 li#menu-item-2390.current-menu-ancestor:not(.hover) a {color:#000000;} .page-id-5451 li#menu-item-2390.current-menu-ancestor:not(.hover) a:after {display:none;} /* Contact Customer Support nav issue fix*/ .page-id-9343 li#menu-item-2390.current-menu-ancestor:not(.hover) a {color:#000000;} .page-id-9343 li#menu-item-2390.current-menu-ancestor:not(.hover) a:after {display:none;} /* custom seach box*/ .search #Content .searchform {display:inline-block; float:left;} .search #Content .searchform h4{clear:both; padding:10px 0px; margin:0px;} .search #Content .searchform input[type=text] {float:left; margin:0px; min-width:350px; padding:7px 10px;} .search #Content .searchform select {-webkit-appearance:menulist; padding:7px 10px;} .search #Content .searchform input[type=submit] {background:#0065a4; margin:0px; margin-left:15px; padding:8px 20px;} @media only screen and (min-width: 320px) and (max-width: 650px) { .search #Content .searchform input[type=text] {min-width:240px;} } @media only screen and (min-width: 320px) and (max-width: 519px) { .search #Content .searchform input[type=submit] {margin:0px; margin-top:15px;} } .wpcf7-form .anr_captcha_field {position:absolute;} /*newsletter archive tables remove border*/ .post.category-newsletter-archive .post-wrapper-content table td {box-shadow:none; border:0px;} .be-ix-link-block {max-width:750px; text-align:center; margin:0px auto; padding-top:20px;} #Footer .widgets_wrapper .column {margin:0px 9px 0px;} @media only screen and (min-width: 768px) and (max-width: 959px) { #Footer .widgets_wrapper .column {margin:0px 5px 0px;} } /*Login page popup */ .page-id-5451.logged-in #pum-8728 {display:none !important;} #cookie-law-info-bar a {color:#fff; text-decoration:underline;} #cookie-law-info-bar a:hover {text-decoration:none;} #cookie-law-info-bar .cli-plugin-button {text-decoration:none;} @media only screen and (min-width: 320px) and (max-width: 767px) { #cookie-law-info-again{display:none !important;} } /*After Multi Language SETUP*/ #Action_bar .column {overflow:visible;} .top-widgets-container .widget_search input[type="text"] {margin-top:5px;} .widget.widget_nav_menu::after, .widget.widget_icl_lang_sel_widget::after, .widget_archive ul li:after, .widget_nav_menu ul li:after {display:none;} .wpml-ls-legacy-dropdown-click {margin-top:6px; } .wpml-ls-legacy-dropdown-click a, .wpml-ls-legacy-dropdown-click a:hover, .wpml-ls-legacy-dropdown-click a:focus, .wpml-ls-legacy-dropdown-click .wpml-ls-current-language:hover>a {color:#626262 !important; border:0px;text-decoration:none;} .wpml-ls-legacy-dropdown-click .wpml-ls-sub-menu {z-index:999;} .top-widgets-container h2.title {display:none;} @media only screen and (min-width: 320px) and (max-width: 767px) { .wpml-ls-legacy-dropdown-click {margin:6px auto 0px; } .top-widgets-container .widget_search {clear:both;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .wpml-ls-legacy-dropdown-click {width:auto;} } #menu-top-navigation-ch .cart a {padding:0px 20px; } #menu-top-navigation-ch .cart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; padding-right:10px; font-size:26px; color:#fff; text-indent:0;} @media only screen and (min-width:320px) and (max-width:767px) { #menu-top-navigation-ch .cart.menu-item-2449 {display:none;} #menu-top-navigation-ch .cart a {padding:0px 10px;} } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-13087 a span {background:#007dc5; color:#fff; border-radius:10px; line-height:40px; margin-top:8px; margin-left:20px;} .mm-vertical #Top_bar .menu > li#menu-item-13087 a:after {display:none;} #Top_bar.is-sticky .menu > li#menu-item-13087 > a, #Top_bar.is-sticky .menu > li#menu-item-13087 > a span {line-height:30px; margin-top:0px;} } .post-9911 .wpcf7 span.wpcf7-list-item{width: 260px;display: inline-block;} .post-9911 span.wpcf7-form-control-wrap{margin-bottom:20px;} .post-9911 .wpcf7-list-item-label{color:#000000;} .post-9911 .unique .one-third.column{width:30.333% !important;} .post-9911 .unique .required{color: #ff0000; font-size: 13px; padding: 0 5px 0 5px;} .post-9911 .wrap .one-second.column{width:32%;} .post-9911 .wpcf7 hr.small {color:#000000;background-color:#000000;height:1px; max-width: 440px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .post-9911 .wpcf7 hr.large{color:#000000;background-color:#000000;height:1px; max-width: 760px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .post-9911 .wpcf7 p strong{font-weight:normal; font-size:18px; color:#1F497D;} @media only screen and (min-width: 320px) and (max-width: 959px) { .post-9911 .wpcf7 span.wpcf7-list-item{width: 100%;} .post-9911 .unique .one-third.column{width:100% !important;} .post-9911 .wrap .one-second.column{width:100%;} .post-9911 span.wpcf7-form-control-wrap {margin-bottom:0px;} } /*remove meta from search-results*/ .search.search-results .post-item .post-meta {display:none;} .search.search-results .post-item .post-desc {padding-left:0px;} /*footer update*/ /*#Footer .widgets_wrapper {padding-bottom:10px;} #Footer .widgets_wrapper .column {margin-bottom:10px;} #Footer #custom_html-4 > h4 {text-align:center;} #Footer #custom_html-14 > h4 {text-align:center;} #Footer #custom_html-9 {max-width:160px; margin:0px auto; clear:both; padding-top:25px;} .footer-resources {max-width:80%; margin:0px auto; } .footer-resources li {float:left; line-height:28px;} .footer-resources li:nth-child(1), .footer-resources li:nth-child(6){width:12%; clear:both;} .footer-resources li:nth-child(2), .footer-resources li:nth-child(7){width:28%;} html[lang="zh-hans"] .footer-resources li:nth-child(1), html[lang="zh-hans"] .footer-resources li:nth-child(6){width:15%; clear:both;} html[lang="zh-hans"] .footer-resources li:nth-child(2), html[lang="zh-hans"] .footer-resources li:nth-child(7){width:25%;} .footer-resources li:nth-child(3), .footer-resources li:nth-child(8){width:17%;} .footer-resources li:nth-child(4), .footer-resources li:nth-child(9){width:18%;} .footer-resources li:nth-child(5), .footer-resources li:nth-child(10){width:25%;} @media only screen and (min-width:320px) and (max-width:1239px) { .footer-resources {max-width:60%; } .footer-resources li:nth-child(1), .footer-resources li:nth-child(6){width:50%; clear:none;} .footer-resources li:nth-child(2), .footer-resources li:nth-child(7){width:50%;} .footer-resources li:nth-child(3), .footer-resources li:nth-child(8){width:50%;} .footer-resources li:nth-child(4), .footer-resources li:nth-child(9){width:50%;} .footer-resources li:nth-child(5), .footer-resources li:nth-child(10){width:50%;} } @media only screen and (min-width:320px) and (max-width:767px) { .footer-resources {max-width:100%; } #Footer #custom_html-4 > h4 {text-align:left;} #Footer #custom_html-14 > h4 {text-align:left;} #Footer #custom_html-9 {max-width:100%;} } */ .tabs_vertical.ui-tabs .ui-tabs-nav li a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li a.button:hover, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button:hover { background: #007dc5; color: #fff; border-radius: 10px !important; text-align: center; margin-left: 20px; margin-top: 20px; display:inline-block; text-decoration: none; padding: 0px 20px !important; border:0px; text-transform: uppercase; line-height:30px; font-size: 15px; font-weight: 400;letter-spacing: 1px;} @media only screen and (min-width:320px) and (max-width:767px) { .tabs_vertical.ui-tabs .ui-tabs-nav li h3, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active h3 {text-align:center;} .tabs_vertical.ui-tabs .ui-tabs-nav li a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li a.button:hover, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button:hover {margin:20px auto;} } /*Webinars latest posts zh-hans*/ .parent-pageid-11725 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .parent-pageid-11725 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .parent-pageid-11725 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .parent-pageid-11725 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .parent-pageid-11725 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .parent-pageid-11725 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .parent-pageid-11725 .Latest_news ul li.category-webinars-zh-hans .desc h5 a{color:#007dc5;} .parent-pageid-11725 .Latest_news ul li .desc_footer .date {display:none;} .parent-pageid-11725 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .parent-pageid-11725 .Latest_news ul li .desc_footer .post-comments {display:none;} .parent-pageid-11725 .Latest_news ul li .desc_footer .button-love {display:none;} .parent-pageid-11725 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .parent-pageid-11725 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Upcoming Live Webinars zh-hans*/ .page-id-11764 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .page-id-11764 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .page-id-11764 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .page-id-11764 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .page-id-11764 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .page-id-11764 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .page-id-11764 .Latest_news ul li.category-webinars-zh-hans .desc h5 a{color:#007dc5;} .page-id-11764 .Latest_news ul li .desc_footer .date {display:none;} .page-id-11764 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .page-id-11764 .Latest_news ul li .desc_footer .post-comments {display:none;} .page-id-11764 .Latest_news ul li .desc_footer .button-love {display:none;} .page-id-11764 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .page-id-11764 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Request Product Quote zh-hans*/ .page-id-12227 .wpcf7 span.wpcf7-list-item{width: 260px;display: inline-block;} .page-id-12227 span.wpcf7-form-control-wrap{margin-bottom:20px;} .page-id-12227 .wpcf7-list-item-label{color:#000000;} .page-id-12227 .unique .one-third.column{width:29% !important;} .page-id-12227 .unique .required{color: #ff0000; font-size: 13px; padding: 0 5px 0 5px;} .page-id-12227 .wrap .one-second.column{width:32%;} .page-id-12227 .wpcf7 hr.small {color:#000000;background-color:#000000;height:1px; max-width: 440px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .page-id-12227 .wpcf7 hr.large{color:#000000;background-color:#000000;height:1px; max-width: 760px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .page-id-12227 .wpcf7 p strong{font-weight:normal; font-size:18px; color:#1F497D;} @media only screen and (min-width: 320px) and (max-width: 959px) { .page-id-12227 .wpcf7 span.wpcf7-list-item{width: 100%;} .page-id-12227 .unique .one-third.column{width:100% !important;} .page-id-12227 .wrap .one-second.column{width:100%;} .page-id-12227 span.wpcf7-form-control-wrap {margin-bottom:0px;} } /*Request Product Info zh-hans*/ .page-id-12612 .wpcf7 span.wpcf7-list-item{width: 260px;display: inline-block;} .page-id-12612 span.wpcf7-form-control-wrap{margin-bottom:20px;} .page-id-12612 .wpcf7-list-item-label{color:#000000;} .page-id-12612 .unique .one-third.column{width:29% !important;} .page-id-12612 .unique .required{color: #ff0000; font-size: 13px; padding: 0 5px 0 5px;} .page-id-12612 .wrap .one-second.column{width:32%;} .page-id-12612 .wpcf7 hr.small {color:#000000;background-color:#000000;height:1px; max-width: 440px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .page-id-12612 .wpcf7 hr.large{color:#000000;background-color:#000000;height:1px; max-width: 760px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .page-id-12612 .wpcf7 p strong{font-weight:normal; font-size:18px; color:#1F497D;} @media only screen and (min-width: 320px) and (max-width: 959px) { .page-id-12612 .wpcf7 span.wpcf7-list-item{width: 100%;} .page-id-12612 .unique .one-third.column{width:100% !important;} .page-id-12612 .wrap .one-second.column{width:100%;} .page-id-12612 span.wpcf7-form-control-wrap {margin-bottom:0px;} } /*Team in zh-hans*/ .page-id-12002.if-overlay .image_frame:hover .image_wrapper img, .page-id-12002.if-overlay .image_frame.hover .image_wrapper img {transform: scale(1);} .page-id-12002 .team .desc_wrapper hr {display:none;} .page-id-12002 .ui-tabs .ui-tabs-panel .column.one-second, .page-id-12002 .ui-tabs .ui-tabs-panel .column.one-fourth, .page-id-12002 .ui-tabs .ui-tabs-panel .column.one-third, .page-id-12002 .ui-tabs .ui-tabs-panel .column.two-third {margin-left:10px; margin-right:10px;} .page-id-12002 .ui-tabs .ui-tabs-panel .column.one-fourth {width:23.4%;} /* product page in zh-hans*/ .page-id-12156 .ui-tabs-panel .team.team_vertical .image_frame {border:0px;} .page-id-12156 .ui-tabs-panel .team.team_vertical hr.hr_color {background:none;} .page-id-12156.if-overlay .ui-tabs-panel .team.team_vertical .image_frame:hover .image_wrapper img, .page-id-12156.if-overlay .ui-tabs-panel .team.team_vertical .image_frame.hover .image_wrapper img {-webkit-transform: scale(1); -moz-transform: scale(1); -o-transform: scale(1); transform: scale(1); } .page-id-12156 .ui-tabs-panel .one-third.column:nth-child(4n-3) {margin-left:10px; margin-right:17px; } .page-id-12156 .ui-tabs-panel .one-third.column:nth-child(4n-2) {margin-left:18px; margin-right:17px; } .page-id-12156 .ui-tabs-panel .one-third.column:nth-child(4n-1) {margin-left:18px; margin-right:10px; } .page-id-12156 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:65px; margin-right:52px; } .page-id-12156 .ui-tabs-panel .one-second.column:nth-child(even) {margin-left:53px; margin-right:65px; } @media only screen and (min-width: 1301px) { .page-id-12156 .ui-tabs-panel .one-third.column {width:30.9%;} .page-id-12156 .ui-tabs-panel .one-second.column {width:40.2%;} } @media only screen and (min-width: 1240px) and (max-width: 1300px) { .page-id-12156 .ui-tabs-panel .one-third.column {width:30.7%;} .page-id-12156 .ui-tabs-panel .one-second.column {width:47.6%;} } @media only screen and (min-width: 960px) and (max-width: 1239px) { .page-id-12156 .ui-tabs-panel .one-third.column {width:29.9%;} .page-id-12156 .ui-tabs-panel .one-second.column {width:36.6%;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .page-id-12156 .ui-tabs-panel .one-third.column {width:28.7%;} .page-id-12156 .ui-tabs-panel .one-second.column {width:38.9%;} } @media only screen and (min-width: 320px) and (max-width: 767px) { .page-id-12156 .ui-tabs-panel .one-third.column {margin-left:0px; margin-right:0px;} .page-id-12156 .ui-tabs-panel .one-second.column:nth-child(even), .page-id-12156 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:0px; margin-right:0px;} } /*Recent Webinars nav issue fix for zh-hans*/ .page-id-11728 li#menu-item-13052.current-menu-ancestor:not(.hover) a {color:#000000;} .page-id-11728 li#menu-item-13052.current-menu-ancestor:not(.hover) a:after {display:none;} .large h3{font-size:22px; line-height:30px;} .small {margin-left:25px;} sup {display:inline-block; margin-top:-4px;} sub {display:inline-block; margin-bottom:-4px;} sup, sub {display:inline-table;} .ui-tabs-panel .one-second.column {width:50%;} .parent-pageid-2582 .ui-tabs-panel td {text-align:left !important;} .ls-borderlessdark3d .ls-shadow { display: none !important;} #menu-top-navigation-de .cart a {padding:0px 20px;} #menu-top-navigation-de .cart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; padding-right:15px; font-size:26px; color:#fff; text-indent:0;} @media only screen and (min-width:320px) and (max-width:767px) { #menu-top-navigation-de .cart.menu-item-14543{display:none;} #menu-top-navigation-de .cart a {padding:0px 10px;} } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-15087 a span {background:#007dc5; color:#fff; border-radius:10px; line-height:40px; margin-top:8px; margin-left:20px;} .mm-vertical #Top_bar .menu > li#menu-item-15087 a:after {display:none;} #Top_bar.is-sticky .menu > li#menu-item-15087 > a, #Top_bar.is-sticky .menu > li#menu-item-15087 > a span {line-height:30px; margin-top:0px;} } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar li#menu-item-12984 a {color:#000 !important; padding-top:20px !important;} .mm-vertical #Top_bar li#menu-item-14978 a {color:#000 !important; padding-top:20px !important;} } #Footer #custom_html-15 > h4 {text-align:center;} /* product page German */ .page-id-14845 .ui-tabs-panel .team.team_vertical .image_frame {border:0px;} .page-id-14845 .ui-tabs-panel .team.team_vertical hr.hr_color {background:none;} .page-id-14845.if-overlay .ui-tabs-panel .team.team_vertical .image_frame:hover .image_wrapper img, .page-id-14295.if-overlay .ui-tabs-panel .team.team_vertical .image_frame.hover .image_wrapper img {-webkit-transform: scale(1); -moz-transform: scale(1); -o-transform: scale(1); transform: scale(1); } .page-id-14845 .ui-tabs-panel .one-third.column:nth-child(4n-3) {margin-left:10px; margin-right:17px; } .page-id-14845 .ui-tabs-panel .one-third.column:nth-child(4n-2) {margin-left:18px; margin-right:17px; } .page-id-14845 .ui-tabs-panel .one-third.column:nth-child(4n-1) {margin-left:18px; margin-right:10px; } .page-id-14845 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:65px; margin-right:52px; } .page-id-14845 .ui-tabs-panel .one-second.column:nth-child(even) {margin-left:53px; margin-right:65px; } @media only screen and (min-width: 1301px) { .page-id-14845 .ui-tabs-panel .one-third.column {width:30.9%;} .page-id-14845 .ui-tabs-panel .one-second.column {width:40.2%;} } @media only screen and (min-width: 1240px) and (max-width: 1300px) { .page-id-14845 .ui-tabs-panel .one-third.column {width:30.7%;} .page-id-14845 .ui-tabs-panel .one-second.column {width:47.6%;} } @media only screen and (min-width: 960px) and (max-width: 1239px) { .page-id-14845 .ui-tabs-panel .one-third.column {width:29.9%;} .page-id-14845 .ui-tabs-panel .one-second.column {width:36.6%;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .page-id-14845 .ui-tabs-panel .one-third.column {width:28.7%;} .page-id-14845 .ui-tabs-panel .one-second.column {width:38.9%;} } @media only screen and (min-width: 320px) and (max-width: 767px) { .page-id-14845 .ui-tabs-panel .one-third.column {margin-left:0px; margin-right:0px;} .page-id-14845 .ui-tabs-panel .one-second.column:nth-child(even), .page-id-14845 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:0px; margin-right:0px;} } .parent-pageid-14845 .ui-tabs-panel td {text-align:left !important;} .button_align.align_left .button {text-align:left; padding:10px 0;} .button_align.align_left .as_tab {font-size: 18px; line-height: 20px; font-weight: 400; background:#fff; letter-spacing: 0px; color: #2991d6 !important; padding: 5px 10px 5px 20px;margin:0; } .button_align.align_left .button.as_tab:hover {text-decoration:underline !important; background-color:#fff!important;} .button_align.align_left .button.as_tab:after {display:none;} .button_align.align_left .button.as_tab.active {color: #000; border-left: 3px solid #2991d6; border-radius: 0px !important; padding: 5px 10px 5px 17px !important;} .button_align.align_left .button.as_tab .button_label {margin:0!important;} .button_align.align_left .button.as_tab_btn { background: #007dc5; color: #fff; border-radius: 10px !important; text-align: center; margin-left: 20px; margin-top: 20px; display: inline-block; text-decoration: none; padding: 0px 20px !important; border: 0px; text-transform: uppercase; line-height: 30px; font-size: 15px; font-weight: 400; letter-spacing: 1px; } /*Japan language*/ #Footer #custom_html-22 > h4 { text-align: center; } #menu-top-navigation-ja .cart a {padding:0px 20px;} #menu-top-navigation-ja .cart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; padding-right:15px; font-size:26px; color:#fff; text-indent:0;} @media only screen and (min-width:320px) and (max-width:767px) { #menu-top-navigation-ja .cart.menu-item-2449 {display:none;} #menu-top-navigation-ja .cart a {padding:0px 10px;} } .mm-vertical #Top_bar .menu > li#menu-item-18403 a span {background:#007dc5; color:#fff; border-radius:10px; line-height:40px; margin-top:8px; margin-left:20px;} .mm-vertical #Top_bar .menu > li#menu-item-18403 a:after {display:none;} #Top_bar.is-sticky .menu > li#menu-item-18403 > a, #Top_bar.is-sticky .menu > li#menu-item-18403 > a span {line-height:30px; margin-top:0px;} @media only screen and (min-width: 1240px) { #Top_bar #menu-german-main-menu > li > a span:not(.description) { padding: 0 3px; font-size:14px; } } body, ul.timeline_items, .icon_box a .desc, .icon_box a:hover .desc, .feature_list ul li a, .list_item a, .list_item a:hover, .widget_recent_entries ul li a, .flat_box a, .flat_box a:hover, .story_box .desc, .content_slider.carousel ul li a .title, .content_slider.flat.description ul li .desc, .content_slider.flat.description ul li a .desc, .post-nav.minimal a i { color: #333333 !important; } .column_column ul, .column_column ol, .the_content_wrapper:not(.is-elementor) ul, .the_content_wrapper:not(.is-elementor) ol { color: #333333 !important; } .hero { margin-top: 20px; } .bg-hero { background: radial-gradient(circle at 100% 0,#ebf1f2 0% 30%,#0e81a7 100%); } .hero-full { min-height: 450px; background-color: rgba(0, 0, 0, 0.5); } .column, .columns { margin: 0px 8px 40px; } .image-container { position: relative; display: inline-block; /* oder 'block' je nach Layout */ } .ribbon { position: absolute; top: 10px; /* Abstand von oben */ left: -20px; /* Verschiebung nach links, um das Ribbon schräg zu positionieren */ background-color: #FF5733; /* Farbe des Ribbons */ color: white; /* Textfarbe */ padding: 5px 15px; /* Innenabstand */ transform: rotate(-0deg); /* Dreht das Ribbon */ transform-origin: 0 0; /* Setzt den Drehpunkt */ font-size: 14px; /* Schriftgröße */ box-shadow: 2px 2px 5px rgba(0,0,0,0.3); /* Schatten für 3D-Effekt */ z-index: 10; /* Stellt sicher, dass das Ribbon über dem Bild liegt */ } .event-badge { position: relative; margin-right: 10px; border-radius: 6px; top: 0px; /* Abstand von oben */ left: 0px; /* Verschiebung nach links, um das Ribbon schräg zu positionieren */ background-color: #007dc5; /* Farbe des Ribbons */ color: white; /* Textfarbe */ padding: 2px 8px; /* Innenabstand */ font-size: 10px; /* Schriftgröße */ box-shadow: 1px 1px 2px rgba(0,0,0,0.3); /* Schatten für 3D-Effekt */ z-index: 10; /* Stellt sicher, dass das Ribbon über dem Bild liegt */ } .btn-default { background: #007dc5; color: #fff; border-radius: 6px; line-height: 40px; margin-top: 8px; margin-left: 20px; padding: 0px 10px; } .wpcf7 form.sent .wpcf7-response-output { color: #ffffff; background-color: #46b450; } .jumpto { padding-top: 100px; /* Adjust this value to match your header's height */ margin-top: -100px; /* This should be the same value as padding-top but negative */ } .post-item { margin-bottom: 40px; position: relative; float: left; width: 100%; border: 1px solid #ccc; padding: 20px; background-color: #f8f8f8; } .post-links { background-color: #007dc5; border: 1px solid #ccc; padding: 5px 20px; } #field_1_18, 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.title > .acc-icon-minus { display: block;} .accordion .question > .title > .acc-icon-plus, .accordion .question .title > .acc-icon-minus {left:15px; top:16px;} .mcb-wrap-inner {display:block;} @media only screen and (max-width: 767px) { .section_wrapper .mcb-wrap, .section_wrapper .column, .container .column { width:100%!important; } } @media only screen and (min-width: 768px) { .be-ix-link-block .be-related-link-container .be-label {flex:0 0 17%;} .be-ix-link-block .be-related-link-container .be-list {flex:0 0 83%;} } ul.clients.appnotes .client_wrapper a, ul.clients.appnotes .client_wrapper .gs-wrapper { justify-content:left; } /*Top bar search*/ #Action_bar #global-searchfield-container .addsearch-searchfield input[type=search].icon {margin-bottom:0px; margin-top:4px; padding:5px 5px 5px 40px!important; height:30px;} #Action_bar #global-searchfield-container .addsearch-searchfield button {display:none;} #Action_bar .adds-components {padding:0px;} /*Top Shadow */ .header-classic #Top_bar { border-bottom: 0px solid #e1e1e1; box-shadow: rgba(0, 0, 0, 0.15) 0px 1.95px 2.6px; margin-bottom: 1px; } .sticky-submenu { position: -webkit-sticky; /* Für Safari */ position: sticky; top: 80px; z-index: 9999; /*background-color: #fff;*/ padding: 10px; /*border-bottom: 1px solid #ccc;*/ text-align: center; } .sticky-submenu ul { list-style-type: none; margin: 0; padding: 0; } .sticky-submenu ul li { display: inline; margin: 0 15px; } .sticky-submenu ul li a { text-decoration: none; /*color: #000;*/ color:#fff; padding: 5px; transition: border-bottom 0.3s; } .sticky-submenu ul li a.active, .sticky-submenu ul li a:hover { /*border-bottom: 2px solid #000;*/ border-bottom: 2px solid #fff; } .page-section { padding: 50px; margin-top: 50px; } .anchor-offset { display: block; position: relative; top: -60px; /* Höhe des sticky-submenu */ } .copyright a {padding:0px 7px;} .before-footer h4 {font-size:18px;} .before-footer .button {border-radius:4px;} .footer-button { padding: 10px 5px; border-radius: 5px; text-align: center; display: inline-block; width: 180px; border:1px solid #fff !important;} #Footer .widget_nav_menu ul { list-style-type: none; padding: 0px; background: none;} #Footer .widget_nav_menu ul a{padding:0px;} #Footer .widget_nav_menu {margin:20px 0px;} #Footer .one-fifth {width:16%;} #Footer .one-fifth:first-child {width:27%;} .social .icon_bar, .social .icon_bar span {width:auto !important; height:auto!important; line-height:0px!important; background-color:transparent; border:0px !important; color:#fff; font-size:24px; -webkit-box-shadow:none;box-shadow:none;} .social a:hover.icon_bar span { -webkit-transform: translateY(0%); -moz-transform: translateY(0%); transform: translateY(0%); } /*30aug2024*/ table tr:first-child td {box-shadow:none;} .btn_radius {border-radius: 4px;} #Top_bar .menu > li > a span:not(.description) {padding:0px 3px;} @media only screen and (min-width: 1300px) { #Top_bar .menu > li > a span:not(.description) {padding:0px 10px;} #Top_bar.is-sticky .menu > li > a span {padding:0px 15px;} } /** Added 11/14/24 **/ .scroll { text-decoration: none; transition: color 0.3s ease, font-weight 0.3s ease; } .scroll.active { font-weight: bold; } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-5221 a span { background: #13b5ea !important; } } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-15087 a span { background: #13b5ea !important; } } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-13087 a span { background: #13b5ea !important; } } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-18403 a span { background: #13b5ea !important; } } /** Added 11/18/24 **/ .header-section { border-bottom: 8px solid #fdbb30 !important; } .header-section .mcb-background-overlay{ } .solution-box { padding: 20px; border: 4px solid #EBEDEF; min-height: 150px; } .image_frame:hover 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</div> </header> </div>  <div id="Content" role="main"> <div class="content_wrapper clearfix"> <main class="sections_group"> <div class="entry-content" itemprop="mainContentOfPage"> <div class="mfn-builder-content mfn-default-content-buider"><section class="section mcb-section mfn-default-section mcb-section-f14a7280a header-section default-width" style="" ><div class="mcb-background-overlay"></div><div class="section_wrapper mfn-wrapper-for-wraps mcb-section-inner mcb-section-inner-f14a7280a"><div class="wrap mcb-wrap mcb-wrap-2b7ac0187 one tablet-one laptop-one mobile-one clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-2b7ac0187 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="wrap mcb-wrap mcb-wrap-547501b92 three-fourth tablet-three-fourth laptop-three-fourth mobile-one mfn-nested-wrap clearfix" data-desktop-col="three-fourth" data-laptop-col="laptop-three-fourth" data-tablet-col="tablet-three-fourth" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-547501b92 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-868be2c64 three-fourth laptop-three-fourth tablet-three-fourth mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-868be2c64 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h1 style="color: white;">AAV characterization and quantitation</h1> <p style="font-size: 18px;">Wyatt’s AAV solutions feature real-time PAT for better yield, precise quantification, and CQA analysis using DLS and MALS, tailored for research and QC needs.</p></div></div></div></div></div></div></div></div></section><section class="section mcb-section mfn-default-section mcb-section-8fa954328 default-width" style="" ><div class="mcb-background-overlay"></div><div class="section_wrapper mfn-wrapper-for-wraps mcb-section-inner mcb-section-inner-8fa954328"><div class="wrap mcb-wrap mcb-wrap-c828f7fd4 one-fourth tablet-one-fourth laptop-one-fourth mobile-one sticky-desktop clearfix" data-desktop-col="one-fourth" data-laptop-col="laptop-one-fourth" data-tablet-col="tablet-one-fourth" data-mobile-col="mobile-one" style="--sticky-offset-desktop:110px" ><div class="mcb-wrap-inner mcb-wrap-inner-c828f7fd4 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="wrap mcb-wrap mcb-wrap-b1d004359 one tablet-one laptop-one mobile-one mfn-item-custom-width mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-b1d004359 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-8c43e31a9 one laptop-one tablet-one mobile-one column_table_of_contents" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-8c43e31a9 mcb-item-table_of_contents-inner"><div class="table_of_content clearfix " data-tags="H2"><div class="title"><h4 class="title-inner">Table of contents</h4></div><div class="table_of_content_wrapper"><ol class="mfn_toc_numbers"><li data-depth="1" ><i></i><a class="scroll" href="#introduction">Introduction</a></li><li><i></i><a class="scroll" href="#aav-analytical-methods-based-on-light-scattering">AAV analytical methods based on light scattering</a></li><li><i></i><a class="scroll" href="#sec-mals-multiple-aav-cqas">SEC-MALS: Multiple AAV CQAs</a></li><li><i></i><a class="scroll" href="#aav-sop-guidance-manual">AAV SOP guidance manual</a></li><li><i></i><a class="scroll" href="#aav-method-implementation-training">AAV method implementation & training</a></li><li><i></i><a class="scroll" href="#dls-high-throughput-for-formulation-screening-and-process-characterization">DLS: High-throughput for formulation screening and process characterization</a></li><li><i></i><a class="scroll" href="#fff-mals-extended-aggregate-characterization">FFF-MALS: Extended aggregate characterization</a></li><li><i></i><a class="scroll" href="#rt-mals-process-analytical-technology-pat-for-aavs">RT-MALS: Process analytical technology (PAT) for AAVs</a></li><li><i></i><a class="scroll" href="#resources">Resources</a></li></ol></div></div> </div></div><div class="column mcb-column mcb-item-c4h5hn8vi one laptop-one tablet-one mobile-one column_plain_text" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-c4h5hn8vi mcb-item-plain_text-inner"><div class="desc"><a href="https://www.wyatt.com/products/request-product-info.html" class="sidebar-btn" target="_blank" rel="noopener noreferrer"> Request Product Information </a></div></div></div></div></div></div></div><div class="wrap mcb-wrap mcb-wrap-b5e4b0b0d three-fourth tablet-three-fourth laptop-three-fourth mobile-one clearfix" data-desktop-col="three-fourth" data-laptop-col="laptop-three-fourth" data-tablet-col="tablet-three-fourth" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-b5e4b0b0d mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div id="introduction" class="wrap mcb-wrap mcb-wrap-b704da88f one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-b704da88f mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-32731d9d3 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-32731d9d3 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Introduction</h2></div></div></div><div class="column mcb-column mcb-item-jxadi1j2 two-third laptop-two-third tablet-two-third mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-jxadi1j2 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><p>Adeno-associated viruses (AAVs) have emerged as one of the main delivery vehicles for gene therapies. With their rapid growth in development and production, it is essential to implement simple, fast AAV quantification methods for accurately determining the critical quality attributes (CQA) of AAV serotypes, as well as providing extended characterization. Analytical methods based on dynamic light scattering (<a href="/solutions/techniques/dynamic-light-scattering-nanoparticle-size.html">DLS</a>) and multi-angle light scattering (<a href="/solutions/techniques/sec-mals-molar-mass-size-multi-angle-light-scattering.html">MALS</a>) are advantageous for quantifying CQAs and other characteristics of AAV vectors: they require no special reagents, extensive sample preparation or calibration curves, are highly reproducible, and results are obtained in just seconds to minutes.</p> <p><i>Click on the buttons to explore how light scattering is used to measure different properties of viral vectors or continue reading to learn about Wyatt solutions to industry and regulatory needs for AAVs.</i></p></div></div></div><div class="column mcb-column mcb-item-j6r5nc9r one-third laptop-one-third tablet-one-third mobile-one column_column column-margin-0px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-j6r5nc9r mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><p align="center"><a class="button button_full_width button_size_2" href="/solutions/aav-titer-and-empty-full-ratio.html" style="background-color:#02386c!important;color:#fff;" target="_blank" title=""><span class="button_label">Titer & Empty-Full Ratio</span></a> </p> <p align="center"><a class="button button_full_width button_size_2" href="/solutions/aav-stability-and-aggregation.html" style="background-color:#005eb8!important;color:#fff;" target="_blank" title=""><span class="button_label">Stability & Aggregation</span></a> </p> <p align="center"><a class="button button_full_width button_size_2" href="/solutions/aav-purity-capsid-size-and-molar-mass.html" style="background-color:#13b5ea!important;color:#fff;" target="_blank" title=""><span class="button_label">Purity & Extended Characterization</span></a> </p> <p align="center"><a class="button button_full_width button_size_2" href="/solutions/techniques/real-time-mals.html" style="background-color:#005eb8!important;color:#fff;" target="_blank" title=""><span class="button_label">Process Analytics</span></a> </p> </div></div></div></div></div><div id="aav-analytical-methods-based-on-light-scattering" class="wrap mcb-wrap mcb-wrap-e7ca7e289 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-e7ca7e289 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-0d20018dc one laptop-one tablet-one mobile-one column_column column-margin-0px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-0d20018dc mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 style="border-bottom: thick solid #ffb600; padding-bottom: 15px;">AAV analytical methods based on light scattering</h2></div></div></div></div></div><div id="sec-mals-multiple-aav-cqas" class="wrap mcb-wrap mcb-wrap-lymnepiln one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-lymnepiln mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-cbi4zg1a one-second laptop-one-second tablet-one-second mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-cbi4zg1a mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2>SEC-MALS: Multiple AAV CQAs</h2> <p>Size-exclusion chromatography combined with multi-angle light scattering (<a href="/solutions/techniques/sec-mals-molar-mass-size-multi-angle-light-scattering.html">SEC-MALS</a>) delivers high-precision AAV quantitation in a <b>single 30-minute experiment</b>. The following AAV quality attributes are measured simultaneously by SEC-MALS:</p> <ul> <li><a href="/solutions/aav-titer-and-empty-full-ratio.html">Empty/full ratio</a></li> <li><a href="/solutions/aav-titer-and-empty-full-ratio.html">Capsid titer (Cp) and genome titer (Vg)</a></li> <li><a href="/solutions/aav-titer-and-empty-full-ratio.html">Aggregate content</a></li> </ul> <p>The same experiments can provide extended characterization of AAV vectors:</p> <ul> <li>Capsid integrity</li> <li><a href="/solutions/aav-purity-capsid-size-and-molar-mass.html">Capsid size (<i>R</i><sub>h</sub> or <i>R</i><sub>g</sub>) and distribution</a></li> <li><a href="/solutions/aav-purity-capsid-size-and-molar-mass.html">Capsid and genome molar mass (<i>M</i><sub>w</sub>)</a></li> <li><a href="/solutions/aav-purity-capsid-size-and-molar-mass.html">Impurities such as free DNA or host-cell proteins</a></li> </ul> <p>Instrument control, data acquisition, analysis and reporting are all provided by <a href="/products/software/astra.html">ASTRA<sup>™</sup></a> software with the <a href="/products/software/astra-benefits.html#benefits-2_viralvector">Viral Vector Analysis module</a>. We provide a platform SEC-MALS method, specifically built for AAV quantitation and is easily customizable for every product and serotype. With ASTRA’s <a href="/products/services/21-cfr-part-11-compliance.html">21 CFR Part 11-compliant</a> option, SEC-MALS is readily positioned for supporting IND or BLA analytics packages, lot-to-lot comparisons and release assays of AAV-based gene therapy products.</p></div></div></div><div class="column mcb-column mcb-item-j2lxk344 one-second laptop-one-second tablet-one-second mobile-one column_image" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-j2lxk344 mcb-item-image-inner"><div class="image_frame image_item no_link scale-with-grid alignnone no_border" ><div class="image_wrapper "><img width="960" height="750" src="https://www.wyatt.com/wp-content/uploads/2024/02/AAV-Attributes-Quantified-960x750-1.webp" class="scale-with-grid" alt="" style="" decoding="async" fetchpriority="high" srcset="https://www.wyatt.com/wp-content/uploads/2024/02/AAV-Attributes-Quantified-960x750-1.webp 960w, https://www.wyatt.com/wp-content/uploads/2024/02/AAV-Attributes-Quantified-960x750-1-300x234.webp 300w, https://www.wyatt.com/wp-content/uploads/2024/02/AAV-Attributes-Quantified-960x750-1-768x600.webp 768w, https://www.wyatt.com/wp-content/uploads/2024/02/AAV-Attributes-Quantified-960x750-1-96x75.webp 96w, https://www.wyatt.com/wp-content/uploads/2024/02/AAV-Attributes-Quantified-960x750-1-640x500.webp 640w, https://www.wyatt.com/wp-content/uploads/2024/02/AAV-Attributes-Quantified-960x750-1-614x480.webp 614w, https://www.wyatt.com/wp-content/uploads/2024/02/AAV-Attributes-Quantified-960x750-1-480x375.webp 480w" sizes="(max-width:767px) 480px, (max-width:960px) 100vw, 960px" /></div></div> </div></div><div class="column mcb-column mcb-item-wclygf8jh one laptop-one tablet-one mobile-one column_html" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-wclygf8jh mcb-item-html-inner"><div class="mfn-html-editor-wrapper"> <div class="responsive-container"> <img src="https://www.wyatt.com/wp-content/uploads/2024/11/thumb-white-paper-wp1615.webp" alt="White Paper Thumbnail"> <div> <h4>White Paper WP1615</h4> <p style="margin: 0 0 10px;"> The white paper <i>WP1615: SEC-MALS for absolute biophysical characterization</i> discusses SEC- MALS technology for biophysical characterization of several biomolecules.</p> <a href="/library/request-wp1615.html" style="" class="cta-box-btn" target="_blank" rel="noopener noreferrer"><i class="fas fa-file-pdf cta-box-icon"></i> Read the White Paper </a> </div> </div></div></div></div></div></div><div id="aav-sop-guidance-manual" class="wrap mcb-wrap mcb-wrap-qa8oveyi one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-qa8oveyi mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-t3t95v5la one-second laptop-one-second tablet-one-second mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-t3t95v5la mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2>AAV SOP guidance manual</h2> <p>This comprehensive document serves as a complete reference and pathway to customizing, qualifying and implementing the SEC-MALS AAV method for your specific needs.</p> <h2 id="aav-method-implementation-training">AAV method implementation & training</h2> <p>Wyatt has developed a personalized AAV training program that saves significant time and effort in learning, method development and validation.</p> <p><a class="button button_size_2" href="/products/services/aav-services.html" style="background-color:#0065a4!important;color:#ffffff;" target="_blank" title=""><span class="button_label">Learn More</span></a> </p> </div></div></div><div class="column mcb-column mcb-item-mv7qjfsk one-second laptop-one-second tablet-one-second mobile-one column_image" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-mv7qjfsk mcb-item-image-inner"><div class="image_frame image_item no_link scale-with-grid aligncenter no_border" ><div class="image_wrapper "><img class="scale-with-grid" src="https://www.wyatt.com/wp-content/uploads/2022/10/aav-dawn-opti-setup.png" alt="A complete SEC-MALS system includes Wyatt’s DAWN<sup>™</sup> MALS detector, an Optilab<sup>™</sup> dRI detector, an AAV separation column and an industry-standard HPLC pump, an autosampler, and a UV detector." title="" width="500" height="399" style=""/></div><p class="wp-caption-text">A complete SEC-MALS system includes Wyatt’s DAWN™ MALS detector, an Optilab™ dRI detector, an AAV separation column and an industry-standard HPLC pump, an autosampler, and a UV detector.</p></div> </div></div></div></div><div id="dls-high-throughput-for-formulation-screening-and-process-characterization" class="wrap mcb-wrap mcb-wrap-60bbbdb99 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-60bbbdb99 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-1oqm9fwid one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-1oqm9fwid mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">DLS: High-throughput for formulation screening and process characterization</h2></div></div></div><div class="column mcb-column mcb-item-tem7jn6op two-third laptop-two-third tablet-two-third mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-tem7jn6op mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><p><a href="/solutions/techniques/dynamic-light-scattering-nanoparticle-size.html">DLS</a> provides rapid, low-volume, non-destructive AAV quantification to determine size, size distribution and physical titer. Typical experiment times are <b>30 seconds per sample</b>.</p> <p><strong>AAV characterization by DLS is essential for:</strong></p> <ul> <li><a href="/solutions/aav-titer-and-empty-full-ratio.html">Monitoring titer</a> of fractions during AAV production, especially in downstream processes</li> <li>Screening buffers and serotypes for colloidal stability and <a href="/solutions/aav-stability-and-aggregation.html">propensity to aggregate</a></li> <li>Assessing thermal stability by measuring the <a href="/solutions/aav-stability-and-aggregation.html">aggregation onset temperature</a>, melting temperature, or the temperature dependence of aggregation kinetics</li> <li><a href="/solutions/aav-stability-and-aggregation.html">Identifying SEC mobile phase</a> or formulation buffers that promote well-assembled product</li> </ul> <p>The <a href="/products/instruments/dynapro-dynamic-light-scattering-plate-reader.html">DynaPro<sup>™</sup> Plate Reader</a> is the premier tool for high-throughput DLS: it evaluates product quality, quantity and stability for up to over a thousand samples at a time. Since the DynaPro Plate Reader measures directly in standard microwell plates, consumable and labor costs are minimal, and common automation tools such as robotic pipettors may be incorporated in the workflow.</p></div></div></div><div class="column mcb-column mcb-item-z4wfgoftp one-third laptop-one-third tablet-one-third mobile-one column_image" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-z4wfgoftp mcb-item-image-inner"><div class="image_frame image_item no_link scale-with-grid aligncenter no_border" style="margin-top:60px;"><div class="image_wrapper "><img width="300" height="220" src="https://www.wyatt.com/wp-content/uploads/2023/09/DynaPro-Plate-Reader-III-1000-300x220.jpg" class="scale-with-grid" alt="DynaPro<sup>™</sup> Plate Reader<br />High-throughput, automated measurements." style="" decoding="async" srcset="https://www.wyatt.com/wp-content/uploads/2023/09/DynaPro-Plate-Reader-III-1000-300x220.jpg 300w, https://www.wyatt.com/wp-content/uploads/2023/09/DynaPro-Plate-Reader-III-1000-768x563.jpg 768w, https://www.wyatt.com/wp-content/uploads/2023/09/DynaPro-Plate-Reader-III-1000-102x75.jpg 102w, https://www.wyatt.com/wp-content/uploads/2023/09/DynaPro-Plate-Reader-III-1000-682x500.jpg 682w, https://www.wyatt.com/wp-content/uploads/2023/09/DynaPro-Plate-Reader-III-1000-655x480.jpg 655w, https://www.wyatt.com/wp-content/uploads/2023/09/DynaPro-Plate-Reader-III-1000-480x352.jpg 480w, https://www.wyatt.com/wp-content/uploads/2023/09/DynaPro-Plate-Reader-III-1000.jpg 1000w" sizes="(max-width:767px) 300px, 300px" /></div><p class="wp-caption-text">DynaPro™ Plate Reader<br />High-throughput, automated measurements.</p></div> </div></div><div class="column mcb-column mcb-item-tkqx6q7t0l one laptop-one tablet-one mobile-one column_html" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-tkqx6q7t0l mcb-item-html-inner"><div class="mfn-html-editor-wrapper"> <div class="responsive-container"> <img src="https://www.wyatt.com/wp-content/uploads/2024/11/thumb-white-paper-wp5003.webp" alt="White Paper Thumbnail"> <div> <h4>White Paper WP5003</h4> <p style="margin: 0 0 10px; line-height: 1.5;"> The white paper <i>WP5003: Automated dynamic and static light scattering in microwell plates for fast, productive development of biologics</i> describes the capabilities of the DynaPro Plate Reader for performing multiple assays.</p> <a href="/library/request-wp5003.html" style="" class="cta-box-btn" target="_blank" rel="noopener noreferrer"><i class="fas fa-file-pdf cta-box-icon"></i> Read the White Paper </a> </div> </div></div></div></div><div class="column mcb-column mcb-item-930o1qokq one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-930o1qokq mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><p>The <a href="/products/instruments/dynapro-nanostar-dynamic-light-scattering-detector.html">DynaPro<sup>™</sup> NanoStar<sup>™</sup></a> performs the same measurements in quartz cuvettes with volumes as low as 2 µL and in disposable cuvettes with just 4 µL.</p> <p>With the suite of instrument control, analyses and visualization tools provided by <a href="/products/software/dynamics.html">DYNAMICS<sup>™</sup></a> software, scientists can easily evaluate multiple product attributes over many samples, to develop stable, robust products and processes.</p></div></div></div></div></div><div id="fff-mals-extended-aggregate-characterization" class="wrap mcb-wrap mcb-wrap-4udquh7ra one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-4udquh7ra mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-h9bexe15 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-h9bexe15 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style="padding:1%;"><h2 class="section-headline">FFF-MALS: Extended aggregate characterization</h2></div></div></div><div class="column mcb-column mcb-item-rastkfnx three-fifth laptop-three-fifth tablet-three-fifth mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-rastkfnx mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style="padding:1%;"><p>For the characterization of large <a href="/solutions/aav-stability-and-aggregation.html">AAV aggregates</a> or other large species, field-flow fractionation in combination with MALS (<a href="/solutions/techniques/fff-mals-characterization-of-nanoparticles-colloids-macromolecules.html">FFF-MALS</a>) is the method of choice. The <a href="/products/instruments/eclipse-field-flow-fractionation-system.html">Eclipse<sup>™</sup></a> FFF system separates particles from 1 – 1000 nm in an open channel with no stationary phase and is invaluable for analyzing particles that are too large for separation by SEC or may be removed or dissociated by column shear.</p></div></div></div><div class="column mcb-column mcb-item-3h1t51fer two-fifth laptop-two-fifth tablet-two-fifth mobile-one column_image" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-3h1t51fer mcb-item-image-inner"><div class="image_frame image_item no_link scale-with-grid alignleft no_border" ><div class="image_wrapper "><img class="scale-with-grid" src="https://www.wyatt.com/wp-content/uploads/2022/10/fff-mals-setup.png" alt="A complete FFF-MALS system includes Wyatt’s Eclipse, DAWN MALS detector, Optilab dRI detector, a separation channel and an industry-standard HPLC pump, an autosampler, and a UV detector." title="" width="500" height="1227" style=""/></div><p class="wp-caption-text">A complete FFF-MALS system includes Wyatt’s Eclipse, DAWN MALS detector, Optilab dRI detector, a separation channel and an industry-standard HPLC pump, an autosampler, and a UV detector.</p></div> </div></div><div class="column mcb-column mcb-item-v7fnu6goq one laptop-one tablet-one mobile-one column_html" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-v7fnu6goq mcb-item-html-inner"><div class="mfn-html-editor-wrapper"> <div class="responsive-container"> <img src="https://www.wyatt.com/wp-content/uploads/2024/11/thumb-app-note-2004.webp" alt="Thumbnail"> <div> <h4>More Information</h4> <p style="margin: 0 0 10px;"> <p>For more information on the theory and applications of FFF-MALS, please refer to our <a href="https://www.wyatt.com/solutions/techniques/fff-mals-characterization-of-nanoparticles-colloids-macromolecules.html" target="_blank">FFF-MALS page</a>, or read AN2004 which describes the characterization and quantitation of large AAV aggregates using FFF-MALS.</p> <a href="/library/request-an2004.html" style="" class="cta-box-btn" target="_blank" rel="noopener noreferrer"><i class="fas fa-file-pdf cta-box-icon"></i> Read the Application Note </a> </div> </div></div></div></div></div></div><div id="rt-mals-process-analytical-technology-pat-for-aavs" class="wrap mcb-wrap mcb-wrap-mniqhb6ar one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-mniqhb6ar mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-80c657e73 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-80c657e73 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">RT-MALS: Process analytical technology (PAT) for AAVs</h2></div></div></div><div class="column mcb-column mcb-item-i81hzmi48 three-fifth laptop-three-fifth tablet-three-fifth mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-i81hzmi48 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><p><a href="/solutions/techniques/real-time-mals.html">RT-MALS</a> is a real-time technology for determining empty/full ratio, titer, molar mass and radius. It is valuable in both early- and late stage process environments to monitor quality, collect the appropriate fraction, or flag deviations from acceptable AAV attribute values. RT-MALS is implemented with an <a href="/products/instruments/ultradawn.html">ultraDAWN<sup>™</sup></a> MALS instrument and <a href="/products/software/observer.html">OBSERVER<sup>™</sup></a> software.</p> <p><strong>Benefits of RT-MALS:</strong></p> <ul> <li>Accelerate process development and scale-up</li> <li>Increase yield, reduce overall time until lot release</li> <li>Maintain product quality with confidence</li> </ul> <p><strong>Applications of RT-MALS:</strong></p> <ul> <li>Chromatographic purification and enrichment of full capsids</li> <li>Concentration of viral vectors by ultrafiltration</li> </ul></div></div></div><div class="column mcb-column mcb-item-0fd8c7b90 two-fifth laptop-two-fifth tablet-two-fifth mobile-one column_image" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-0fd8c7b90 mcb-item-image-inner"><div class="image_frame image_item no_link scale-with-grid aligncenter no_border" style="margin-bottom:20px;"><div class="image_wrapper "><img class="scale-with-grid" src="https://www.wyatt.com/wp-content/uploads/2022/06/ultraDAWN-On-line-Workflow-Vertical-6-29-22-1200.jpg" alt="ultraDAWN-On-line-Workflow-Vertical-6-29-22-1200" title="" width="400" height="1278" style=""/></div></div> </div></div><div class="column mcb-column mcb-item-r6pzp5vqh one laptop-one tablet-one mobile-one column_html" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-r6pzp5vqh mcb-item-html-inner"><div class="mfn-html-editor-wrapper"> <div class="responsive-container"> <img src="https://www.wyatt.com/wp-content/uploads/2024/11/thumb-app-note-8008.webp" alt="Thumbnail"> <div> <h4>Application Note AN8008</h4> <p style="margin: 0 0 10px;"> Learn how RT-MALS is used to accelerate the development of a process for AAV enrichment by ion-exchange chromatography in our application note <i>AN8008: Real-time monitoring and control of AAV chromatographic enrichment with RT-MALS</i>.</p> <a href="/solutions/an8008-request.html" style="" class="cta-box-btn" target="_blank" rel="noopener noreferrer"><i class="fas fa-file-pdf cta-box-icon"></i> Read the Application Note </a> </div> </div></div></div></div></div></div><div id="resources" class="wrap mcb-wrap mcb-wrap-9k1omd2wt one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-9k1omd2wt mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-5b2ebb30f one laptop-one tablet-one mobile-one column_column column-margin-20px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-5b2ebb30f mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Resources</h2></div></div></div></div></div><div id="process-analytical-technology-for-lnps" class="wrap mcb-wrap mcb-wrap-l7jqzbk64 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-l7jqzbk64 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-afpn1m00b one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-afpn1m00b mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style="padding:2%;"><h3>Webinars:</h3> <ul style="list-style: none; padding: 0; margin: 0;"> <li style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px; justify-content: flex-start;"><i class="fa-regular fa-circle-play" style="color: #8a8a8d; font-size: 20px;"></i> <a href="/library/webinars/biophysical-characterization-and-quality-control-of-vaccines-and-gene-vectors-with-light-scattering.html" target="_blank" rel="noopener">Viral vector characterization by DLS, SEC-MALS and FFF-MALS multi-detector system.</a></li> <li style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px; justify-content: flex-start;"><i class="fa-regular fa-circle-play" style="color: #8a8a8d; font-size: 20px;"></i> <a href="/library/webinars/quantification-of-viral-and-non-viral-vector-cqas.html" target="_blank" rel="noopener">Quantification of viral and non-viral vector CQAs by DLS, SEC-MALS, FFF-MALS, and PAT applications</a></li> <li style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px; justify-content: flex-start;"><i class="fa-regular fa-circle-play" style="color: #8a8a8d; font-size: 20px;"></i> <a href="/library/webinars/virtual-user-meeting-protein-conjugate-and-copolymer-analysis.html" target="_blank" rel="noopener">The special case of viral vector/AAV analysis</a></li> </ul></div></div></div></div></div><div id="process-analytical-technology-for-lnps" class="wrap mcb-wrap mcb-wrap-yjfxihogw one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-yjfxihogw mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-bf1a93312 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-bf1a93312 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style="padding:2%;"><h3>Application Notes / White papers:</h3> <ul style="list-style: none; padding: 0; margin: 0;"> <li style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px; justify-content: flex-start;"><i class="fas fa-file-pdf" style="color: #8a8a8d; font-size: 22px;"></i> <a href="https://wyattfiles.s3-us-west-2.amazonaws.com/literature/app-notes/AAV-Application-Notebook.pdf" target="_blank" rel="noopener">AAV Application Notebook</a></li> <li style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px; justify-content: flex-start;"><i class="fas fa-file-pdf" style="color: #8a8a8d; font-size: 22px;"></i> <a href="https://wyattfiles.s3-us-west-2.amazonaws.com/literature/white-papers/Optimizing-Analysis-of-Viral-Vectors-with-SEC-MALS-eBook.pdf" target="_blank" rel="noopener">E-book: Optimizing the Analysis of Viral Vectors with Light Scattering</a></li> <li style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px; justify-content: flex-start;"><i class="fas fa-file-pdf" style="color: #8a8a8d; font-size: 22px;"></i> <a href="https://wyattfiles.s3.us-west-2.amazonaws.com/literature/app-notes/fff-mals/AN2004-How_to_quantify_AAV+aggregates_by_FFF-MALS.pdf" target="_blank" rel="noopener">Why and how to quantify AAV aggregates by FFF-MALS</a></li> </ul></div></div></div></div></div><div id="process-analytical-technology-for-lnps" class="wrap mcb-wrap mcb-wrap-o9ucvx67 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-o9ucvx67 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-i57p7igf one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-i57p7igf mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style="padding:2%;"><h3>Brochures:</h3> <ul style="list-style: none; padding: 0; margin: 0;"> <li style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px; justify-content: flex-start;"><i class="fa-solid fa-arrow-up-right-from-square" style="color: #8a8a8d; font-size: 16px;"></i> <a href="/products/services/aav-solutions-guide-request.html" target="_blank" rel="noopener">AAV Solutions Guide</a></li> <li style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px; justify-content: flex-start;"><i class="fa-solid fa-arrow-up-right-from-square" style="color: #8a8a8d; font-size: 16px;"></i> <a href="/request-biologics-guide.html" target="_blank" rel="noopener">Characterization of Biologics and Complex Drugs</a></li> </ul></div></div></div></div></div><div id="process-analytical-technology-for-lnps" class="wrap mcb-wrap mcb-wrap-hm9dsjzb one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-hm9dsjzb mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-pcstqqo6m one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-pcstqqo6m mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h3>Featured publications:</h3> <ul> <li><a href="https://www.mdpi.com/1422-0067/23/21/12715" target="_blank" rel="noopener">Biophysical Characterization of Adeno-Associated Virus Vectors Using Ion-Exchange Chromatography Coupled to Light Scattering Detectors</a> - International Journal of Molecular Sciences (2022).</li> <li><a href="https://www.sciencedirect.com/science/article/pii/S2329050121001352" target="_blank" rel="noopener">Comparison of analytical techniques to quantitate the capsid content of adeno-associated viral vectors</a> - Molecular Therapy: Methods & Clinical Development (2021).</li> <li><a href="https://doi.org/10.1038/s41598-021-82599-1" target="_blank" rel="noopener">Comprehensive characterization and quantification of adeno associated vectors by size exclusion chromatography and multi angle light scattering</a> - Scientific Reports (2021).</li> <li><a href="https://www.liebertpub.com/doi/10.1089/hum.2020.054" target="_blank" rel="noopener">Detailed Protocol for the Novel and Scalable Viral Vector Upstream Process for AAV Gene Therapy Manufacturing</a> - Human Gene Therapy (2021).</li> </ul> <p>For additional publications see <a href="https://wyattfiles.s3-us-west-2.amazonaws.com/literature/app-notes/others/PL9008-Key-publications-on-the-characterization-of-gene-vectors-by-light-scattering.pdf" target="_blank" rel="noopener">PL9008: Key publications on the characterization of gene vectors by light scattering</a></p></div></div></div></div></div></div></div></div></section></div><section class="section mcb-section the_content no_content"><div class="section_wrapper"><div class="the_content_wrapper "></div></div></section> <section class="section section-page-footer"> <div 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