GMP Small Molecule Production for Ancillary Reagents

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paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:h1_2_2_text_to_media:field_indv_h1"> <div><h1>GMP Small Molecules for Stem Cell Therapy Manufacturing</h1></div> </div> <div class="field_block:paragraph:h1_2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>GMP Small Molecules are used as ancillary reagents in the further manufacture of stem cell therapies. Ancillary reagents are used in the reprogramming, expansion, and differentiation of stem cells, but are not intended to be present in the final product.</p></div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:h1_2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/images/webinar/LP_images/t-cell-manufacturing-small-molecules-v2.png" alt="Small molecules" fetchpriority="high" > </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> </div> </header> </div> <div id="main" class="container-fluid container-wide"> <div class="row"> <div class="col-md-12"> <div> <div id="block-bio-techne-global-breadcrumbs" class="system_breadcrumb_block"> <nav role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/gmp-products">GMP Products</a> </li> <li> GMP Small Molecules </li> </ol> </nav> </div> </div> </div> </div> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <article> <div> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a href="#find">Find Your GMP Small Molecule</a> | <a href="#products">GMP Products and Services</a> | <a href="#resources">Resources</a> | <a href="#about">FAQs</a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>GMP Small Molecules as Ancillary Reagents</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>Stem cells offer great potential for use as therapies in regenerative medicine. They can be used to generate cells to replace lost or unhealthy cells in a wide range of conditions including trauma, diabetes and Parkinson’s disease. The small molecules used as ancillary materials in the generation of stem cell therapies are required to be safe, reliable, consistent and quality-assured in order to ensure the safety of the stem cell therapy. Our GMP Small Molecules, manufactured according to cGMP guidelines, provide this assurance.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2><a name="find"></a>GMP Small Molecules</h2> <figure class="responsive-figure-table"><table class="table table-bordered"> <thead> <tr> <th> <p><strong>Product Name</strong></p> </th> <th> <p><strong>Catalog #</strong></p> </th> <th> <p><strong>Description</strong></p> </th> </tr> </thead> <tbody> <tr> <td> <p><a href="/p/small-molecules-peptides/chir-99021_tb4423-gmp">CHIR 99021</a></p> </td> <td> <p>TB4423-GMP</p> </td> <td> <p>GSK-3 Inhibitor and WNT pathway activator. Enables reprogramming of human somatic cells into iPSCs</p> </td> </tr> <tr> <td> <p><a href="/p/small-molecules-peptides/ldn-193189_tb6053-gmp">LDN 193189</a></p> </td> <td> <p>TB6053-GMP</p> </td> <td> <p>Potent and selective ALK2 and ALK3 inhibitor. Promotes neural induction of hPSCs</p> </td> </tr> <tr> <td> <p><a href="/p/small-molecules-peptides/sb-431542_tb1614-gmp">SB 431542</a></p> </td> <td> <p>TB1614-GMP</p> </td> <td> <p>TGF Beta 1 (TGF-β1), ALK4 and ALK7 Inhibitor. Replaces SOX2 in reprogramming of fibroblasts to iPSCs</p> </td> </tr> <tr> <td> <p><a href="/p/small-molecules-peptides/xav-939_tb3748-gmp">XAV 939</a></p> </td> <td> <p>TB3748-GMP</p> </td> <td> <p>Tankyrase Inhibitor; inhibits WNT signaling. Promotes cardiomyocyte differentiation from ESCs</p> </td> </tr> <tr> <td> <p><a href="/p/small-molecules-peptides/y-27632-dihydrochloride_tb1254-gmp">Y-27632</a></p> </td> <td> <p>TB1254-GMP</p> </td> <td> <p>Selective ROCK Inhibitor. Increases survival of ESCs and iPSCs undergoing cryopreservation</p> </td> </tr> </tbody> </table></figure></div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="products"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <h2>Additional GMP Products and Services</h2> <div class="row card_row"> <div class="col-md-6"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/gmp-products/gmp-proteins" > <div class="teaser-card-image-crop mb-3"> <img loading="lazy" class="card-background-image card-img-top" src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/dw-gmp-small-molecules-cytokines-background.png" /> </div> <div class="card-foreground-image"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/proteinsolo08a.png?2.png" alt="Structure of R&D Systems GMP Protein" loading="lazy" > </div> </a> <a class="card_title_link" href="/gmp-products/gmp-proteins" > <h3 class="card_title_htag"> <div><h3>GMP Cytokines and Growth Factors</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Our large portfolio of GMP proteins is backed by our dedication to providing cell therapy manufacturers with a consistent, safe, and traceable supply of reagents.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/gmp-products/gmp-proteins" > View All GMP Proteins </a> </div> </div> </div> </div> </div> <div class="col-md-6"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.rndsystems.com/services/gmp-antibody-services" > <div class="teaser-card-image-crop mb-3"> <img loading="lazy" class="card-background-image card-img-top" src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/dw-gmp-small-molecules-antibodies-background-v3.png" /> </div> <div class="card-foreground-image"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/antibodiesSolo05.png" alt="Antibody" loading="lazy" > </div> </a> <a class="card_title_link" href="https://www.rndsystems.com/services/gmp-antibody-services" > <h3 class="card_title_htag"> <div><h3>Custom GMP Antibodies</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Our GMP antibodies are manufactured recombinantly for use in drug discovery, diagnostic, and cell & gene therapy manufacturing processes.</p> <h3> </h3></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.rndsystems.com/services/gmp-antibody-services" > R&D Systems Custom GMP Antibody Services </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <div class="row card_row"> <div class="col-md-6"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/gmp-products/gmp-capabilities" > <div class="teaser-card-image-crop mb-3"> <img loading="lazy" class="card-background-image card-img-top" src="https://resources.bio-techne.com/images/webinar/LP_images/cgt-gmp-capabilities-benefits-background.png" /> </div> <div class="card-foreground-image"> <img src="https://resources.bio-techne.com/images/webinar/LP_images/cgt-gmp-capabilities-transitioning-research.png" alt="GMP" loading="lazy" > </div> </a> <a class="card_title_link" href="/gmp-products/gmp-capabilities" > <h3 class="card_title_htag"> <div><h3>GMP Capabilities</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Learn about the quality standards and certifications for each of our GMP facilities as well as our quality control testing capabilities. We serve clients from around the world, and we guarantee the confidentiality of every contract.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/gmp-products/gmp-capabilities" > View Our GMP Capabilities </a> </div> </div> </div> </div> </div> <div class="col-md-6"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/services/gene-engineering-services-tcbuster" > <div class="teaser-card-image-crop mb-3"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/dw-ges-page-img-8-v4.png" alt="Cell Engineering Services graphic" loading="lazy" > </div> </a> <a class="card_title_link" href="/services/gene-engineering-services-tcbuster" > <h3 class="card_title_htag"> <div><h3>GMP Cell Manufacturing and Process Development</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>We offer process development services for any gene modified therapy, GMP patient processing for Phase I and Phase II clinical trials, and GMP manufacturing of iPSC cell lines.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/services/gene-engineering-services-tcbuster" > View GMP Cell Manufacturing and Process Development </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="resources"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <h2>GMP Small Molecule Resources</h2> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/resources/literature/t-cell-therapies-ebook" > <div class="teaser-card-image-crop mb-3"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/t-cell-ebook-featured-350x210.jpg" alt="image of T Cell-Based Therapies eBook" loading="lazy" > </div> </a> <a class="card_title_link" href="/resources/literature/t-cell-therapies-ebook" > <h3 class="card_title_htag"> <div><h3>eBook: T Cell-Based Therapies</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>This eBook outlines biological and manufacturing challenges facing T cell therapies. It follows with examples of how Bio-Techne products and services address these challenges. </p></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/literature/t-cell-therapies-ebook" > Download eBook </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.tocris.com/literature/life-science-posters/stem-cell-workflow" > <div class="teaser-card-image-crop mb-3"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/dw-gmp-small-molecules-stem-cell-workflow-poster-background.png" alt="GMP Small Molecules Stem Cell Workflow Poster" loading="lazy" > </div> </a> <a class="card_title_link" href="https://www.tocris.com/literature/life-science-posters/stem-cell-workflow" > <h3 class="card_title_htag"> <div><h3>Poster: Stem Cell Workflow Using Small Molecules</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Our Tocris Stem Cell Workflow poster summarizes how small molecules have been used in protocols across the stem cell workflow, and highlights some of the key advantages of using small molecules. </p></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.tocris.com/literature/life-science-posters/stem-cell-workflow" > Request or Download Poster </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.tocris.com/resources/protocols/stem-cells" > <div class="teaser-card-image-crop mb-3"> <img loading="lazy" class="card-background-image card-img-top" src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/dw-gmp-small-molecules-stem-cell-protocol-background.png" /> </div> <div class="card-foreground-image"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/stemCellSolo04.png?v=2.png" alt="Stem Cells" loading="lazy" > </div> </a> <a class="card_title_link" href="https://www.tocris.com/resources/protocols/stem-cells" > <h3 class="card_title_htag"> <div><h3>Protocols: Key Stem Cell Protocol Highlights</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Our Stem Cell Protocol snapshots highlight how small molecules may be used in place of or alongside proteins in cell culture, reprogramming and differentiation procedures. </p></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.tocris.com/resources/protocols/stem-cells" > View Tocris Stem Cell Protocols </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph accordion mb-4 paragraph--type--extendable-paragraph paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#expPara-additional-resources2" role="button" aria-expanded="false" aria-controls="expPara"> <h5>Additional Resources</h5> </a> </div> <div class="collapse" id="expPara-additional-resources2" aria-expanded="false" aria-controls="expPara"> <div class="card-body p-4"> <br/> <div><p><a href="/gmp-products/gmp-capabilities">GMP Capabilities</a></p> <p><a href="/research-areas/stem-cells">Stem Cells</a></p> <p><a href="/research-areas/regenerative-medicine">Regenerative Medicine</a></p> <p><a href="/research-areas/immune-cell-therapy">Immune Cell Therapy</a></p></div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>About GMP Small Molecules</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>GMP small molecules are important in the manufacture of stem cell therapies for translational research and clinical applications, where they are used as ancillary reagents. Ancillary reagents are utilized in the growth and manipulation of <a href="/research-areas/stem-cells">stem cells</a>. Although they are not intended to be present in the final cell therapy product, they may influence its safety, so the use of GMP ancillary reagents is advisable.</p> <p>The clinical phases of development of any therapy are highly regulated in order to mitigate the risk to patient safety, and this includes the use of GMP ancillary reagents (raw materials) for developing stem cell therapies. Our GMP small molecules are manufactured following relevant sections of <a href="https://www.ich.org/page/quality-guidelines" target="_blank">ICH Q7</a> guidelines (Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients), which ensures batch-to-batch consistency, traceability from starting material to final product and animal-free production.</p> <p><strong>View Our <a href="/research-areas/cell-and-gene-therapy">Cell and Gene Therapy</a> Resources</strong></p></div> </div> </div> <div> <div class="thin-banner banner_wrapper"> <div class="banner-dark"> <div> <div><h2>RUO to Ancillary Materials to GMP</h2></div> <a href="/gmp-products/ruo-to-gmp" > <button type="button" class="btn btn-primary"> Streamline Your Transition to GMP </button> </a> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_header_2_global"> <div><h3>Serum-Free and Animal-Free Cell Culture</h3></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p> </p> <p>Increase the consistency of your cell cultures as you approach translational studies for regenerative medicine and cell therapy programs. Adopting these media will</p> <ul> <li>Reduce variability in media composition</li> <li>Simplify compliance with regulatory guidelines</li> <li>Simplify comparability testing for raw material changes</li> </ul></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_call_to_action_global"> <a href="/reagents/cell-culture-reagents/serum-free-animal-free" class="btn btn-primary" type="link"> Culture Your Cells Serum-Free and Animal-Free </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_indv_media"> <div> <a href="https://www.bio-techne.com/reagents/cell-culture-reagents/serum-free-animal-free" title="Culture Your Cells Serum-Free and Animal-Free" target="_self" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/adherent-cells-culture-v2.jpg" alt="Adherent cells in culture supported by extracellular matrix" loading="lazy" > </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <a href="https://www.bio-techne.com/promotions/excellerate-ipsc-medium-sample" title="Try Our GMP iPSC Medium" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/products/gmp-excellerate-ipsc-expansion-medium-angle-1.png" alt="GMP ExCellerate iPSC Expansion Medium" loading="lazy" > </a> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div><h3>New! ExCellerate™ GMP iPSC Expansion Medium</h3></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>For seamless transition from our equivalent RUO iPSC Expansion Medium. Both media support robust expansion and maintenance of pluripotent stem cell culture for enhanced consistency and reproducibility.</p> <ul> <li>Completely animal-free</li> <li>All-in-one formulation</li> <li>Stable cell integrity over long term culture</li> </ul></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_call_to_action_global"> <a href="/promotions/excellerate-ipsc-medium-sample" class="btn btn-primary" type="link"> Try Our GMP iPSC Medium </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="about"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--background-information mb-4 paragraph--view-mode--default"> <div class="row"> <div class="col"> <div> <h3>Background Information </h3> </div> <div> <div id="accordion" class="paragraph paragraph--type--background-about paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#aboutPara-about-gmp-small-molecules14" role="button" aria-expanded="false" aria-controls="aboutContents"> <h5>About GMP Small Molecules</h5> </a> </div> <div class="collapse" id="aboutPara-about-gmp-small-molecules14" aria-expanded="false" aria-controls="aboutContents"> <div class="card-body"> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>GMP small molecules are important in the manufacture of stem cell therapies for translational research and clinical applications, where they are used as ancillary reagents. Ancillary reagents are utilized in the growth and manipulation of <a href="/research-areas/stem-cells">stem cells</a>. Although they are not intended to be present in the final cell therapy product, they may influence its safety, so the use of GMP ancillary reagents is advisable.</p> <p>The clinical phases of development of any therapy are highly regulated in order to mitigate the risk to patient safety, and this includes the use of GMP ancillary reagents (raw materials) for developing stem cell therapies. Our GMP small molecules are manufactured following relevant sections of ICH Q7 guidelines (Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients), which ensures batch-to-batch consistency, traceability from starting material to final product and animal-free production.</p> <p><strong>View Our <a href="/research-areas/cell-and-gene-therapy">Cell and Gene Therapy</a> Resources</strong></p></div> </div> </div> </div> </div> </div> </div> </div> <div> <div id="accordion" class="paragraph paragraph--type--faq-container paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#faqPara-faqs24" role="button" aria-expanded="false" aria-controls="faqPara"> <h5>FAQs</h5> </a> </div> <div class="collapse" id="faqPara-faqs24" aria-expanded="false" aria-controls="faqPara"> <div class="card-body p-4"> <div> <div> <div class="paragraph paragraph--type--individual-faq paragraph--view-mode--default"> <div><h4>What is the difference between RUO and GMP small molecules?</h4></div> <div><p>We manufacture our GMP (current Good Manufacturing Practice) small molecules according to relevant sections of ICH Q7 guidelines. They can be categorized in the risk tier 2 classification (low risk, well characterized materials with intended use as ancillary reagents, produced in compliance with GMP) of USP <1043>. Our RUO (research use only) products, like those of other suppliers, are categorized in the risk tier 3 classification (moderate-risk materials not intended for use as ancillary reagents) of USP <1043>.</p> <p>Each vial is weighed to a precise amount. We also carry out microbiological testing on our GMP small molecules, specifically endotoxin and bioburden testing.</p> <p><strong>Explore our <a href="/support/cofa-finder-tool">Certificate of Analysis Finder Tool</a>.</strong></p></div> </div> </div> <div> <div class="paragraph paragraph--type--individual-faq paragraph--view-mode--default"> <div><h4>Are GMP small molecules animal-free?</h4></div> <div><p>Yes. We ensure that our GMP small molecules are animal-free.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--individual-faq paragraph--view-mode--default"> <div><h4>Can GMP small molecules be used as therapeutics?</h4></div> <div><p>No. Our GMP compounds are intended for use only as ancillary reagents for the further manufacture of advanced therapy medicinal products (ATMP), such as stem cell therapies.</p> <p><strong>Watch our webinar on the <a href="https://info.bio-techne.com/WBNBIO-TECHNE-2020-07webinar-AnalysingATMPS_LP-webinar-main.html" target="_blank">Challenges of Analyzing ATMPs</a>.</strong></p></div> </div> </div> <div> <div class="paragraph paragraph--type--individual-faq paragraph--view-mode--default"> <div><h4>Why has Bio-Techne developed a GMP product line?</h4></div> <div><p>As stem cell therapies are now entering the clinic, there is a requirement to use GMP compounds as ancillary reagents to ensure the safety and suitability of the stem cell therapy product. By introducing a GMP product line, Bio-Techne is fulfilling its commitment to provide the life science community with the latest and most relevant reagents available, to make new discoveries possible.</p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </article> </div> </div> </section> </main> </div> <div id="brandsbar-footer" class="bg-bt-primary"> <div class="container-wide container-fluid text-white"> <div class="row py-5"> <div class="footer-logo col-xl-3 col-lg-auto d-flex"> <img class="brand-bar-footer-logo" src="/themes/custom/bio_techne_global/logo.svg" alt="Bio-techne logo"> </div> <div class="col-xl-9 col-lg-auto"> <p class="ml-xl-4 bt-px_groteskbold footer-tagline">Global Developer, Manufacturer, and Supplier of High-Quality Reagents, Analytical Instruments, and Precision Diagnostics.</p> </div> <div class="included-brands col"> <span class="font-weight-bold mr-3 bt-inter_regular">INCLUDES</span> <span class="mr-3 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