CINXE.COM

Just a moment...

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "www.science.org",cType: 'managed',cRay: '8e7d17f08e89603e',cH: 'pStvj24BOkcK87mI1MgtcKgLLILkx0MoFViXO07Y3Bk-1732490048-1.2.1.1-Ew9sCWcxf2jLNLMpwzMiOwes9scH8yiliXG6TODCyP.jX2w9_gOD09KVJHVQcQCE',cUPMDTk: "\/doi\/10.1126\/sciadv.adg3747?__cf_chl_tk=kMOSMq1brkkg129J.QYV9iNaIcq7DDNqm4M1wJjkR7g-1732490048-1.0.1.1-HX3qtQwP66C0cvQCfPACvHpzNHnxXyoATOFEagniPts",cFPWv: 'g',cITimeS: '1732490048',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1126\/sciadv.adg3747?__cf_chl_f_tk=kMOSMq1brkkg129J.QYV9iNaIcq7DDNqm4M1wJjkR7g-1732490048-1.0.1.1-HX3qtQwP66C0cvQCfPACvHpzNHnxXyoATOFEagniPts",md: "RjjrOz9M2p9oXkxuc8mvTsHuGLUN30m7Q9YnCviPegg-1732490048-1.2.1.1-95W3VovADwvfhCzGD1.vBYzKIbJGMycvbBg5S3DjHyaLW9Y2nxtiUM8QOxipAqfAKJi7GubJXWcc4hjibCVPSu9hgSY03ca1009ln2b.bZpuGB81Nv9tuA2Z_Md_b_phqgdK3ISzUsc7GbZ3EQWYaRtEYHKBlRGVfTMUG5Gt.7NEWlEf8UYIo9DXBYwPmORNRGmH2_GB_2AnoRmif6eUDlz3jMgkrqaeR_59JyKntab2dDiwqrUcEoBzt_X26vZkyRH_L_xv9alwQDYvlETENb.nbM4owXYF1Vb9dJs8oQn9envtvmTfbDxMW4dvF6xfahPQ7.lyTy.zZur7xgQCLGflNne509soqbU8vi9bB_L2KXUsDypN4G02EJVhMB9paSxzZp3ZQVjlAq8t1ZI2Ynf4f0evuaaaDhV7EoVcSVhPS70c1uz4TJyukGGAo2eqFT02fJpQu7gTstJ.repjj8cjGMXPNEECVOQ_Pkz8IPTs3Ga0rALBLlHlgnVajY49EXvjd11nXfK1Z_Ml7fxgOVTv0t0xoTvI5iudswTL7EEFR0hrkFbavypDxxooOsJYrUyHJsu_5.q5EMIEex5_hnbOq4S9ssX1xUGI2BnrDpic74qeP72iBiaYvZRfsl4YHOoX3068RmqWYM4FwgpUn2YJPpQge5TAAJ8JGdlF8tJituqugd.9ov7X6JgnRuQOwkz3FP9nqHER4P_gKNjeyI8DZob7b3XMRFJTtcXtGqnXvxQBAARuo1z1E_GqtSu3LB1sbCVcmXg5H4f8RYGMuum8HbS8jXE9izYCGD6AiSnky_hNDE8U712yZ7nSQFEXZjvzt9AhdzSgnUyrrHOZz_iCz_1YwyHwVi1jKo5aUOz_LfgJU3XjneZ4.fkCDFj9td7QFy_kEWxt5EcSXodhFfbz1X8AcW12O454p4.E1WIRAjGLZ.Serv7wWU2acO7sXs5VmpZoXX6nIdFhTYy4uJCs.PI9.c3GLbRJcisyK9.lbcmlP3M7YgLZcknyZApM91Eei.wndM5JbtVnMxN0I4SYXIzmduuajo65WCxhVuqBW6phm83DnGlMa4OxjX0b65B1h4AQxdiHxAxPFXZ1xVOf4r8.YOw5njbKOPmujWwMgyVGbaxp4fV3_X_qprTiUpfna9wRyK6Qb57Upc37A28ae7Cvh2pm_pb7zFLpC.8wNLsLApBu7nzMnsruNbeum2V4nUEQoEuasl2g48ukjXRtSSj_2J6aTSmGCVH_Kvr5rIc_4ltij4YQkLkD_YnXZx62ID1HJwhCtB73io06xOQt6KtVOjjJmWdOEZxTg99_afK_qgsVqpeYDA4btGK648EzsxuEO0ezkdzkLSjaJKP2Y.8.t.puE2Xu5fqYkGORk1TyNKLGajoiQpJPHli7ntC0czZjuXecdu92PQyTXYU_NvbaXmCIj3ogrc7Yby12QwSyLvY_JneiIwJ0TJdkQ2D_eQow_isCSuR0qN_EetdiqnigkzIqTFHVtEPcDcqwtJbPiF7mfyhJeZyHLtW19_BBDADot9fm0MjWctQObisnO91HH.ReW4nt4Qs.tiyw0QFJCJXSDlj5keG2G5CAlEY0RZZ36axYhHr8suprPcJNy33E2TofiGJauN6ZQfByWVPDbhUAj4YiySLj9wuTSjBTgPsqvVrvOKj.EJQ9zOGtmz4fEFCU49c6eRmv.IcPJXkokGa5RpoxIgYou6pTNnIRv.RguUjPgiqxZSADh3_ZZNGuhgWW4j5H30wGqUv3OOpTuwgmTqlsg6SUWnu7R9ptkB6AVOxW3V.XZ4yfwSqApCp4V1I7P68k1rZIoIaThIs0lyi.cAdQqoFgPdS8iUcT.8fSRxQQJTLdbZ5yIIOrwrT7LvNIb6i2NJVVNsidVz4hDviv8SBA2iJGI._WzIXQ2F29b5fiTrV92rxmOJsgCI.NnLJ5IpfyF__t.57Q3UlIfvxLXQL.BBCI8qqqnEcyUoUs7C9I8Mn8uFVgvj01MFjOsKakp75utnmKpeFkdd0gBEsakH8jn7RyvRdINkCoFKiKnIOrt0otWQi8ICZ_J0VYYNIvYVG7jUUwHR4j0SjXRHHklSfJhB1ZEVBN7AJ_bvxOraFs4NfL4e6hG5iK_U1CD5FcYh0__wfETXh2MjH5imn0_pwfGPPbzqVGsJbwsefOv4Et7b9i3CsA8y7z9fevPpeI3y7a23LDj7pArdua9De8ctKeXJOxtH5_GUXe48s8SImRbiOvuEGljifohoJgFHDKObBsVsMlPAqEZCWlWtge3QaaOU9zloudhS8tl8.OETDAtLOV1UGPj.9sYQsBH0YMhaDLx617manKOrrV.kguRrMvvMPvmyF2nf0QINQhL5Dd3dRippXPHbt1acJDeak4gfwyApYhMWo6JzB7q6zBsye5k_kS.FXJSEn2I433PEB5PFlIViRDgLFqdKAYJ74IoVgHATjo0IZx.tQLzZ3YTSP.LzOmYW3p8u9f0XpKPUGJW_tWkMTVH7siOFts5cj1uBaEdzGJS4RU_gTeC3V8oSK_Qr4M0qPj6Ybtf0g1Ulscp5P2GTUYmWdGlfp7WADG..SGU2K_UixsMdF.W_T9U7vBP409DAYGHONDE9k4QNmYJ7pHaVWcKM6kJWAdOqBREfrDS42.KHlkMvlojQJG4fl9T7.Bfq80MQ4PUBp_Y5R.doe1axgQehA3FFks0m_0YQjHqQHT26BolTCZsIq9WwJDOOgNOBD8TQEw5qo_yCegSfY7Sf_102JmhYwnxFEyPLn36q1LbIp3MptMFDSGHJkI4TOSBg2pKZFpC2ylsyNmcGAjuDJ9cDn6s97NtIP3WYflac2cUAZJlTx3g2yIIgVl4V0fXPcqgeAyCD7afAt_ZQLRY4p7bpgeRwhYNRlHZBI0E1Fxoz8UjF_hbLjoSv79Ces2zIRgsnqtlNHK7f3i2bqr1TQZN35MidtBChuH2bYLZKJNcc8",mdrd: "tWRSPz9prd.ZwEHI21Jw8DkrdPE6QJNHiN63zCVRYCI-1732490048-1.2.1.1-FN9igpAiVrcHZlOGPF8VFcO_mJMOkIw6RCRVAO13fETgi6uo.DvOOGuq6p2NclHvMmXB4ElSRwQEag5dLvp.fYn4rTU1GBd7G8tWzCcL0CVpeaScSuHCPIRpMUSQXs7_umTB7JiYH.TxV5RWsPazCEXrGW.iInP9JcNHzANK.J5_t_7Tvh_a9q7wlXDy4a1EsMooVQQ.5GA0.jg9fV0_OXUTaMj0phtUcrL7qy8WhiHCpn9HA_6QNfuuji5eruh10_4K9VARmpJvgACGrtkPTnPua5LwXBkOQ4SryTfhcHNaeRlOiYmN14aYp_RmkeQxQjN6xDZOEJmznr61TZfa.ztmHSa04zELS8mBREXnHdfs7tqO0y1D6_G87wDBEG.BwYvDxnK8OAl.Tl_tnJLl.a3pFtmGZUMuDCaZdCr9zNz9UDwX_SoreLudyiGj32myUBPunutMD8GVSfLtTkniMyxx7ZWQLddlKbPCOVWw6ifD9hgULyYQ8j8UYKQtrnEQiPr6Y1Q_n1PzTK2.j4r02L10ggUEWiHquhRYaQpbKAwlFvqBMjW30sSnb0.IeMjQPFn6B8Ios91cBJ89o_gv4_4boXNZJExPlpJOoqHEYfWBDGbpJoT52Y43T1JjZCoKQ05J9tIgpbwHcnf3ZZd6Aa2k_tsVGMyH0oQuQwG77JVrJk3_3KfKRTGTaT5xf7Day_gB9H0AjADVjql8.FGO8YK1QrPa.TGABb0d5xaIL64kttHuOoKinTbK6zV5jFfUt1KkHb34muhM.au6Dh2X5Fm2yS77V_kuS3gdOWoG83UIR5r4IBBXY2jML_ir432FQ0haEer62xA6luiB2ZldM4MotJI1ohqfGNYTU2I5Qi8wK7t8tmKYhSubR.Jj.SSj7jgGB1j4v8JdJMBLSNPNB4wYNQTNECkR2r.wJiTPCcoliOr1m4uEtu0ZaRGHQWyksgC5LJzyVNSXu3UZsYMGIWJE2RkfRC6AefZgzFpWD0ZM0jZTZ_OceEq.8L2.T8sak8O3psFfUI7Q_El.UBcBcy8am_QYp_Nv1DLe0jrVzmebklPPXNyz0r_xKAlwlCsxu3K5QV6DrQJpyFZZCHcBMGJ3ZnsHPTgNdGRWqpozD973GASqGmeqmF9wFbtnfXnzloIZ2ZGfB6xxlbA1M_TwnrizGON.XuqY2wXresvl7FcQi_wPeSBdgIKW1o6KnE6q2ENulgVSUfI7utqyOQoL4Rdj4FH4Ni_RMbgKUusPDiNMcbkuWMlqExd6XH1U3SUp1CpowdTj3AdzFhiw8idN5mxR3dSObMaKZjqH3GAiqRK0Ct3_9SuOg3SlPIBGqqoVlbENWTV4YP2sSl9UjssLF3ZnD6lqBn6W3s9F26MHecOdFL_WmHfILBAoFS5Hm30Mb.kJsXcV96Hr3QDBY7NA0X7s3gemwFm30oekfrxjCTABsaLLBZhyNg_hD5vIR8q9.3jDAPC2q18Cm8KMzKZJzg02OU70eTooTVWy8ffCqUmmCQ_s81ZR6YBNjLCNNDCamWxTNEl.ZHhjkDmO6DIC_wtaOdx7XyxJ1iYGdLM4SrBLAD_qYZlyFmeqFDHQRHCclcyf0gwCC6kskKjos_NBfmfVeG8GmImS.dGWQDwF79AxEGxVnZDUZQmaOPtN7eXc3nmo4CatvKIgTKCg.JT9q9hD03xL9N.4cMG2ss5HeGj46ypLvasgNzG6.BPYaRDglt5u2eT5JFIGTuJXGi1cy_FiFgL.AD2n8WEm68aHPekcbCPxlJp8DFPPYJBAOj_k4cKq8XigL7a7_1oqxuhtYmOR2PCQMbW6yKI6rPZ9kuoptDHk6NahKnw9U3VtlVX3sAWo1NR68rTR_2BDFud4VikR2gvO.NjSG4tfcIeM8z5RR0l8lNTx79VKIMjvZU1JaxzjU8LVGZD2c8KohLl86xTtnnWmOxfIHCQRArmKK.o"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=8e7d17f08e89603e';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1126\/sciadv.adg3747?__cf_chl_rt_tk=kMOSMq1brkkg129J.QYV9iNaIcq7DDNqm4M1wJjkR7g-1732490048-1.0.1.1-HX3qtQwP66C0cvQCfPACvHpzNHnxXyoATOFEagniPts" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>