Hepato-renal protective potential of dimethyl fumarate in alloxan-induced mice model of diabetes type 1

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} </script> <script src="//translate.google.com/translate_a/element.js?cb=googleTranslateElementInit"></script> </ul> </div> </nav> <div class="container-fluid bg-grey"> <div class="container pt-3 pb-4"> <div class="white-container mt-4"> <h2 class="bg-hdr">Hepato-renal protective potential of dimethyl fumarate in alloxan-induced mice model of diabetes type 1</h2> <p><strong>Introduction:</strong> Diabetes mellitus is a growing epidemic and is the most common cause of chronic kidney disease and liver failure. Therefore, there is an urgent need to develop more effective medication-assisted treatments.</p> <p><strong>Methods:</strong> In this study, forty female mice were divided into eight groups with five animals in each. Type 1 diabetes mice models was established using multiple low-dose alloxan, and the diabetic mice were treated with three doses of dimethyl fumarate (DMF) i.e low, medium, and high viz. 20, 40 and 80 mg/kg, respectively for a period of 21 days. Then, specific test were done to evaluate blood biochemical parameters, oxidative stress markers, inflammatory cytokine, and histopathological changes in mice kidney and liver.</p> <p><strong>Results:</strong> Diabetic liver and kidney tissue showed marked dilation of bile ducts, tubules, infiltration, and inflammation. In addition, nuclear factor erythroid-2 related factor 2 (Nrf2) and its downstream effectors (Sirt1) were suppressed in these two diabetic tissues (p< 0.001). On the contrary, diabetic mice treated with DMF showed improvement in oxidative stress indices, inflammation, and this with increased Nrf2 and Sirt1 activation (p< 0.001).</p> <p><strong>Conclusion:</strong> Collectively, it can be concluded that the role of DMF as a blood sugar reducer and improvement of diabetes complications is very significant, likely via reducing activation of pro-inflammatory cytokines function. Although, some contradictory effects of inflammatory factors were observed in kidney and liver tissues, but overall, the therapeutic combination of DMF and metformin (MET) has a good hepato-renal protective ability in alloxan-induced diabetic mice model.</p> <div class="border-top py-2"><b>Posted by: </b>Ramin Ataee, Associate Prof, Mazandaran University of Medical Sciences, Iran (<span class="f-sm">22-May-2023</span>)</div> </div> </div> </div> <div class="container_fluid"> <div class="bg-footer"> <div class="container py-4"> <div class="d-flex justify-content-center pt-4"> <div class="text-center f-sm"> <a href="/" title="Home page" class="text-grey me-2">Home</a><span class="me-1">|</span> <a href="/international-conferences/" title="Conferences" class="text-grey me-1">Conferences</a><span class="me-1">|</span> <a href="/international-exhibitions/" title="International Exhibition" class="text-grey me-2">Exhibitions</a><span class="me-1">|</span> <a href="/event-organizers/" 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Hepato-renal protective potential of dimethyl fumarate in alloxan-induced mice model of diabetes type 1