CINXE.COM

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id="recombinant-proteins" name="recombinant-proteins"> <div class="row"> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="/research-area/ubiquitin-and-ubiquitin--like-modifiers"><img alt="Ubiquitin and Ubiquitin-like Modifiers" class="img-responsive center-block" src="//resources.rndsystems.com/images/design/ubi-ubi-250x250.png" /></a> <div class="group-title-wrapper"> <p><a href="/research-area/ubiquitin-and-ubiquitin--like-modifiers"><strong>Ubiquitin and<br /> Ubiquitin-like Modifiers </strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="/products/e3-ligases"><img alt="E3 Ligases" class="img-responsive center-block" src="//resources.rndsystems.com/images/design/e3-250x250.png" /></a> <div class="group-title-wrapper"> <p><a href="/products/e3-ligases"><strong>E3 Ligases </strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a 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href="/search?keywords=APPBP1+or+ATG7+or+ISG15+or+NEDD8+or+SAE1+or+UBA3+or+UBE1+or+UBA5+or+PYR41+or+NSC624206+or+ATG3+or+UBE2+or+UbcH+or+Uev1a+or+Ufc1+or+Use1+or+CC0651+or+Bay11-7821"><strong>E1 and E2<br /> Enzymes </strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="https://www.tocris.com/product-type/targeted-protein-degradation" target="_blank"><img alt="PROTACs and Targeted Protein Degradation" class="img-responsive center-block" src="//resources.rndsystems.com/images/design/trac-250x250.png" /></a> <div class="group-title-wrapper"> <p><a href="https://www.tocris.com/product-type/targeted-protein-degradation" target="_blank"><strong>PROTACs<sup>®</sup> and Targeted<br /> Protein Degradation </strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="/services/bulk-quote-request"><img alt="Bulk Proteins" class="img-responsive center-block" 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href="/research-area/ubiquitin--like-modifiers--ubls--and-regulators">Ubiquitin-like Modifiers and Regulators</a>, <a href="/search?keywords=ubiquitin%20mutant">mutants</a>, <a href="/search?keywords=uf-%20or%20uc-%20or%20ucm-%20or%20ucn-%20or%20ucb-&category=Proteins%20and%20Enzymes&brand=rnd">chains</a>, and <a href="/search?keywords=a-101+OR+a-104+OR+a-110">antibodies</a></p> <p><a href="/search?keywords=sumo">SUMO</a>, <a href="/target/nedd8">NEDD8</a>, <a href="/target/fat10">FAT10</a>, <a href="/target/isg15-ucrp">ISG15</a>, and <a href="/target/ufm1">UFM1</a><strong> </strong></p> <h2 style="margin-top: 30px">E1 Activating Enzymes</h2> <p style="margin-top: 20px">E1 <a href="/research-area/e1-ubiquitin-ubl-activating-enzymes">enzymes</a> and <a href="/search?keywords=nae+inhibitor">inhibitors</a></p> <h2 style="margin-top: 30px">E2 Conjugating Enzymes</h2> <p style="margin-top: 20px">E2 <a href="/research-area/e2-ubiquitin-ubl-conjugating-enzymes">enzymes</a> and <a href="/search?keywords=(ubc*%20AND%20conjugating)%20OR%20a-615&category=Primary%20Antibodies">antibodies</a></p> <h2 style="margin-top: 30px">E3 Ligases</h2> <p style="margin-top: 20px">E3 <a href="/products/e3-ligases">ligases</a>, <a href="/products/e3-ligases">inhibitors</a>, and <a href="/products/e3-ligases">accessory proteins</a></p> <h2 style="margin-top: 30px">Affinity Matrices</h2> <p style="margin: 20px 0px 30px 0px"><a href="/search?keywords=u-400+OR+(agarose+AND+ucn-*)+OR+(agarose+AND+ul-*)">Affinity matrices</a></p> </div> <div class="col-xs-4"> <h2 style="margin-top: 30px">Deubiquitinating/Deconjugating Enzymes</h2> <p style="margin-top: 20px">Deubiquitinating/deconjugating <a href="/research-area/deubiquitinating-enzymes--dubs">enzymes</a>, <a href="/target/deubiquitinating-enzyme-inhibitors">inhibitors</a>, and <a href="/search?keywords=deubiquitinase&category=Primary%20Antibodies">antibodies</a></p> <h2 style="margin-top: 30px">Heat Shock Proteins</h2> <p style="margin-top: 20px">Heat shock <a href="/search?keywords=hsp*%20AND%20ap-*&category=Proteins%20and%20Enzymes">proteins</a>, <a href="/search?keywords=hsp%20inhibitors&category=Small%20Molecules">inhibitors</a>, and <a href="/search?keywords=hsp&category=Primary%20Antibodies">antibodies</a></p> <h2 style="margin-top: 30px">Buffers and Substrates</h2> <p style="margin: 20px 0px 30px 0px"><a href="/search?keywords=buffer&category=Supplemental%20Reagents">Buffers</a> and <a href="/search?keywords=substrate&category=Peptides&brand=rnd">substrates</a></p> <h2 style="margin-top: 30px">Proteasome</h2> <p style="margin: 20px 0px 20px 0px">Proteasome <a href="/search?keywords=(e-*%20AND%20proteasome)%20OR%20immunoproteasome&category=Proteins%20and%20Enzymes">enzymes</a>, <a href="/search?keywords=i-*%20AND%20proteasome&category=Small%20Molecules">inhibitors</a>, and <a href="/search?keywords=leu&category=Peptides">substrates</a></p> </div> </div> </div> </div> </div> </div></div></div></p></div> </div> </div> </div><div class="field-item even"><div class="entity entity-paragraphs-item paragraphs-item-title-and-basic-html" about="" typeof=""> <div class="content"> <div class="group-basic-div field-group-div"><p class="group-desc field-group-html-element"><div class="field field-name-field-teaser-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><p> </p> <h2 style="line-height: 30px">R&D Systems is your best source for Ubiquitin Proteasome System (UPS) related research products.</h2> <p style="margin-top: 20px">With over 20 years’ experience providing high quality recombinant proteins, small molecules, and substrates to the ubiquitin research community, R&D Systems has built the widest available selection of ubiquitin and ubiquitin-related products. We develop and manufacture our proteins using the latest protein expression and purification strategies and pride ourselves on delivering quality proteins that perform as expected.. As the ubiquitin research field evolves and grows, R&D Systems is there to provide you with the best tools to advance your research.</p> <p>We offer a large range of full-length recombinant deubiquitinases (deubiquitylases, or DUBs) such as <a href="/target/usp7?category=Proteins%20and%20Enzymes">USP7</a> for enzymatic assays and high throughput screening campaigns, and provide the best quality DUB substrates such as <a href="/products/recombinant-human-ubiquitin-amc-protein-cf_u-550">Ubiquitin-AMC</a>, <a href="/products/recombinant-human-ubiquitin-rhodamine-110-protein-cf_u-555">Ubiquitin-rhodamine</a> and <a href="/products/recombinant-human-isg15-amc-protein-cf_ul-553">ISG15-AMC</a>.</p> <p>If you need help with Targeted Protein Degradation (TPD or PROTACS<sup>®</sup>) assays, we provide a rapidly expanding portfolio of highly active <a href="/products/e3-ligases">E3 Ubiquitin Ligases</a> including <a href="/search?keywords=vhl&category=Proteins%20and%20Enzymes">VHL</a> and <a href="/search?keywords=crbn&category=Proteins%20and%20Enzymes">Cereblon</a> (CRBN) proteins.  We also provide <a href="/search?keywords=cullin&category=Proteins%20and%20Enzymes">Cullin-Rbx</a> complexes (including <a href="/search?keywords=cullin&category=Proteins%20and%20Enzymes&common_name=NEDD8">neddylated cullins</a>) that can be coupled to your purified substrate binding complexes to generate active ligases.</p> <p>Interested in Alzheimer’s, Parkinson’s or ALS research?  We have recombinant <a href="/target/tau?category=Proteins%20and%20Enzymes">Tau</a> proteins, <a href="/target/alpha-synuclein?category=Proteins%20and%20Enzymes">α-Synuclein</a> and <a href="/products/recombinant-human-tdp-43-tardbp-protein-cf_ap-190">TDP-43</a>, as well as the most active <a href="/products/recombinant-human-his6-usp30-protein-cf_e-582">USP30</a> and <a href="/target/parkin?category=Proteins%20and%20Enzymes">Parkin</a> (PARK2) enzymes available.</p> <h2 style="margin-top: 30px">About Us</h2> <p style="margin-top: 20px">R&D Systems Ubiquitin-Proteasome Group, formerly known as Boston Biochem, is the leading global producer of ubiquitin-related research products. Since 1997, it has been our mission to provide ubiquitin proteasome system (UPS) researchers with innovative tools that facilitate and accelerate drug discovery efforts. We specialize in providing the highest quality ubiquitin and ubiquitin-like (Ubl) proteins, E1, E2 and E3 Ubiquitin ligases, proteasomes and other UPS-related reagents. Extensive expertise in protein purification, characterization and assay development, as well as a close relationship with the UPS research community, allows us to offer the most comprehensive product range available. The same ubiquitin expertise and quality that you have come to expect from Boston Biochem will continue within R&D Systems. We look forward to hearing from you and learning how we can help advance your research efforts.</p> <h2 style="margin-top: 30px">Can’t Find Your Protein? <a href="/services/protein-services">Talk to us!</a></h2> <p style="margin: 20px 0px 30px 0px">With the sheer number of proteins encompassing the ubiquitin field, we must prioritize which proteins to produce. We may not offer your protein, but it could be in development. Please reach out to our <a href="/services/protein-services">Custom Protein Team</a> to inquire about your protein of interest.</p> </div></div></div></p></div> </div> </div> </div><div class="field-item odd"><div class="entity entity-paragraphs-item paragraphs-item-title-and-basic-html" about="" typeof=""> <div class="content"> <div class="group-basic-div field-group-div"><p class="group-desc field-group-html-element"><div class="field field-name-field-teaser-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even"><h2 style="margin-top: 30px">Other Resources</h2> <ul style="margin-top: 20px"> <li><a href="/products/proteins">Recombinant Proteins</a></li> <li><a href="/products/enzymes">Enzymes</a></li> <li><a href="https://www.tocris.com/product-type/targeted-protein-degradation">Targeted Protein Degradation</a></li> <li><a href="/services/bulk-quote-request">Bulk Proteins</a></li> <li><a href="/services/protein-services">Custom Protein Services</a></li> </ul> <p style="margin: 20px 0px 30px 0px"><small><em>PROTAC<sup>®</sup> is a registered trademark of Arvinas Operations, Inc., and is used under license.</em></small></p> </div></div></div></p></div> </div> </div> </div></div></div></div> </div></div><div class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3 group-featured-content-wrapper field-group-div"><h2 class="field-group-html-element"><div class="field field-name-field-featured-content-title field-type-text field-label-hidden"><div class="field-items"><div class="field-item even"> Featured Content</div></div></div></h2> <div class="paragraphs-items paragraphs-items-field-featured-content paragraphs-items-field-featured-content-full paragraphs-items-full"> <div class="field field-name-field-featured-content field-type-paragraphs field-label-hidden"><div class="field-items"><div class="field-item even"><div class="entity entity-paragraphs-item paragraphs-item-featured-content" about="" typeof=""> <div class="content"> <div class="collapsible group-featured-content field-group-div m-featured-product speed-fast effect-none"> <h3><span class="field-group-format-toggler">Featured Content</span></h3> <div class="field-group-format-wrapper" style="display: block;"><h4 class="group-title-wrapper field-group-html-element"><div class="field field-name-field-featured-title field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.tocris.com/product-type/targeted-protein-degradation" target="_blank">Targeted Protein Degradation Guide</a></div></div></div></h4><div class="required-fields group-img-wrapper field-group-html-element"><div class="field field-name-field-img field-type-et-image-field field-label-hidden"><div class="field-items"><div class="field-item even"><div class=""> <div class="hero-image-text-content"> <div class="hero-image-text-content-inner"> </div> </div> <img loading="lazy" src="https://resources.rndsystems.com/images/design/tpd-750x471.jpg" class="et-image-image" title="Targeted Protein Degradation Guide" alt="Targeted Protein Degradation Guide" /> </div> </div></div></div></div><p class="group-featured-content-text field-group-html-element"><div class="field field-name-field-featured-content-text field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">The brochure highlights to products and services available from Bio-Techne to support Targeted Protein Degradation research.</div></div></div></p><div class="group-learn-more-wrapper field-group-html-element btn btn-tertiary"><div class="field field-name-field-learn-more field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.tocris.com/product-type/targeted-protein-degradation" target="_blank">Download PDF</a></div></div></div></div></div></div> </div> </div> </div><div class="field-item odd"><div class="entity entity-paragraphs-item paragraphs-item-featured-content" about="" typeof=""> <div class="content"> <div class="collapsible group-featured-content field-group-div m-featured-product speed-fast effect-none"> <h3><span class="field-group-format-toggler">Featured Content</span></h3> <div class="field-group-format-wrapper" style="display: block;"><h4 class="group-title-wrapper field-group-html-element"><div class="field field-name-field-featured-title field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.tocris.com/literature/scientific-posters/targeted-protein-degradation" target="_blank">A Chemical Toolbox to Support PROTACs</a></div></div></div></h4><div class="required-fields group-img-wrapper field-group-html-element"><div class="field field-name-field-img field-type-et-image-field field-label-hidden"><div class="field-items"><div class="field-item even"><div class=""> <div class="hero-image-text-content"> <div class="hero-image-text-content-inner"> </div> </div> <img loading="lazy" src="https://resources.rndsystems.com/images/site/featured-tocris-protac-750x471.jpg" class="et-image-image" title="Targeted Protein Degradation Scientific Poster" alt="Targeted Protein Degradation Scientific Poster" /> </div> </div></div></div></div><p class="group-featured-content-text field-group-html-element"><div class="field field-name-field-featured-content-text field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">This poster discusses the generation of a toolbox of building blocks for the development of Degraders</div></div></div></p><div class="group-learn-more-wrapper field-group-html-element btn btn-tertiary"><div class="field field-name-field-learn-more field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://www.tocris.com/literature/scientific-posters/targeted-protein-degradation" target="_blank">Download 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