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mechanism of action</title> <meta name="description" content="Search results for: extract mechanism of action"> <meta name="keywords" content="extract mechanism of action"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="extract mechanism of action"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 7280</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: extract mechanism of action</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7280</span> Anti-Microbial Activity of Senna garrettiana Extract</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Pun%20Jankrajangjaeng">Pun Jankrajangjaeng</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Senna garrettiana is a climatic tropical plant in Southeast Asia. Senna garrettiana (Craib) is used as a medicinal plant in Thailand, in which the experiment reported that the plant contains triterpenoids, ligans, phenolics, and fungal metabolites. Thus, it is also reported that the plant possesses interesting biological activity such as antioxidant activity. Therefore, Senna garrettiana is selected to examine the antimicrobial activity. The purpose of this study is to examine the antimicrobial activity of Senna garrettiana (crab) extract against Gram-positive Staphylococcus aureus and Gram-negative Salmonella typhi, and the fungus Candida albicans. This study performed the agar disk-diffusion method and broth microdilution by using five concentrations of plant extract to determine the minimum inhibitory concentration (MIC) of S. garrettiana extract. The result showed that S. garrettiana extract gave the maximum zone inhibition of 11.7 mm, 13.7 mm, and 14.0 mm against S. aureus, S. typhi, and C. albicans, respectively. The MIC value of S. garrettiana against S. aureus was 125 µg/mL while the MIC in S. typhi and C. albicans greater than 2000 µg/mL. To conclude, S. garrettiana extract showed higher sensitivity of antibacterial activity against gram-positive bacteria than gram-negative bacteria. In addition, the plant extracts also possessed antifungal activity. Therefore, further investigation to confirm the mechanism of action of antimicrobial activity in S. garrettiana extract should be performed to identify the target of the antimicrobial action. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20activity" title="antimicrobial activity">antimicrobial activity</a>, <a href="https://publications.waset.org/abstracts/search?q=Candida%20albicans" title=" Candida albicans"> Candida albicans</a>, <a href="https://publications.waset.org/abstracts/search?q=Salmonella%20typhi" title=" Salmonella typhi"> Salmonella typhi</a>, <a href="https://publications.waset.org/abstracts/search?q=Senna%20garrettiana" title=" Senna garrettiana"> Senna garrettiana</a>, <a href="https://publications.waset.org/abstracts/search?q=Staphylococcus%20aureus" title=" Staphylococcus aureus"> Staphylococcus aureus</a> </p> <a href="https://publications.waset.org/abstracts/140930/anti-microbial-activity-of-senna-garrettiana-extract" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/140930.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">196</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7279</span> The Influence of Temperature on the Corrosion and Corrosion Inhibition of Steel in Hydrochloric Acid Solution: Thermodynamic Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fatimah%20Al-Hayazi">Fatimah Al-Hayazi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ehteram.%20A.%20Noor"> Ehteram. A. Noor</a>, <a href="https://publications.waset.org/abstracts/search?q=Aisha%20H.%20Moubaraki"> Aisha H. Moubaraki</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The inhibitive effect of Securigera securidaca seed extract (SSE) on mild steel corrosion in 1 M HCl solution has been studied by weight loss and electrochemical techniques at four different temperatures. All techniques studied provided data that the studied extract does well at all temperatures, and its inhibitory action increases with increasing its concentration. SEM images indicate thin-film formation on mild steel when corroded in solutions containing 1 g L-1 of inhibitor either at low or high temperatures. The polarization studies showed that SSE acts as an anodic inhibitor. Both polarization and impedance techniques show an acceleration behaviour for SSE at concentrations ≤ 0.1 g L-1 at all temperatures. At concentrations ≥ 0.1 g L-1, the efficiency of SSE is dramatically increased with increasing concentration, and its value does not change appreciably with increasing temperature. It was found that all adsorption data obeyed Temkin adsorption isotherm. Kinetic activation and thermodynamic adsorption parameters are evaluated and discussed. The results revealed an endothermic corrosion process with an associative activation mechanism, while a comprehensive adsorption mechanism for SSE on mild steel surfaces is suggested, in which both physical and chemical adsorption are involved in the adsorption process. A good correlation between inhibitor constituents and their inhibitory action was obtained. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=corrosion" title="corrosion">corrosion</a>, <a href="https://publications.waset.org/abstracts/search?q=inhibition%20of%20steel" title=" inhibition of steel"> inhibition of steel</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrochloric%20acid" title=" hydrochloric acid"> hydrochloric acid</a>, <a href="https://publications.waset.org/abstracts/search?q=thermodynamic%20study" title=" thermodynamic study"> thermodynamic study</a> </p> <a href="https://publications.waset.org/abstracts/148994/the-influence-of-temperature-on-the-corrosion-and-corrosion-inhibition-of-steel-in-hydrochloric-acid-solution-thermodynamic-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/148994.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">100</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7278</span> The Mechanism of Antimicrobial Activity and Antioxidant Effects of the Essential Oil and the Methanolic Extract of Carum montanum (Coss. et Dur.) Benth. Et Hook. Aerial Parts from Algeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Meriem%20El%20Kolli">Meriem El Kolli</a>, <a href="https://publications.waset.org/abstracts/search?q=Hocine%20Laouer"> Hocine Laouer</a>, <a href="https://publications.waset.org/abstracts/search?q=Hayet%20El%20Kolli"> Hayet El Kolli</a>, <a href="https://publications.waset.org/abstracts/search?q=Salah%20Akkal"> Salah Akkal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The methanolic extract (ME) of C. montanum obtained by a hydo-alcoholic maceration and its polyphenol content was evaluated by Folin-Ciocalteu method. This extract and C. montanum essential oil were screened for antimicrobial activity against 21 microbial strains by agar diffusion method. MICs of the EO were determined by the broth micro dilution method. The mechanism of action of the EO was determined on the susceptible strains by the time kill assay and the lysis experience. Antioxidant properties were studied by both free DPPH radical scavenging and reducing power techniques. The TPC in the ME showed a high level of 101.50 ± 5.33 mg GAE /mg. B. cereus was the most sensitive strain with MIC of 55.5 µg/ml , then K. pneumoniae (111 µg/ml). A remarkable decrease in a survival rate as well as in the absorbance at 260 nm were recorded, which suggest that the cytoplasm membrane is one of the targets of the EO. Antioxidant effects were concentration dependent and IC50 values were 1.09 ± 0.37 µg/ml for the EO and 65.04 ± 0.00 µg/ml for the ME by DPPH method and a reducing power dose-dependent. In conclusion, C. montanum extracts showed potent which could be exploited in the food industry for food preservation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=C.%20montanum" title="C. montanum">C. montanum</a>, <a href="https://publications.waset.org/abstracts/search?q=Apiaceae" title=" Apiaceae"> Apiaceae</a>, <a href="https://publications.waset.org/abstracts/search?q=essential%20oils" title=" essential oils"> essential oils</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20activity" title=" antimicrobial activity"> antimicrobial activity</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title=" antioxidant activity"> antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=reducing%20power" title=" reducing power"> reducing power</a> </p> <a href="https://publications.waset.org/abstracts/41814/the-mechanism-of-antimicrobial-activity-and-antioxidant-effects-of-the-essential-oil-and-the-methanolic-extract-of-carum-montanum-coss-et-dur-benth-et-hook-aerial-parts-from-algeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41814.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">236</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7277</span> Antioxidant Activity Of Gracilaria Fisheri Extract</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Paam%20Bidaya">Paam Bidaya</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The red seaweed Gracilaria fisheri, widely distributed along Thailand's southern coastlines, has been discovered to be edible. Sulfated polysaccharides from G. fisheri were extracted in low-temperature (25 °C) water. Seaweed polysaccharides (SPs) have been shown to have various advantageous biological effects. This study aims to investigate total phenolic content and antioxidant capacity of G. fisheri extract. The total phenolic content of G. fisheri extract was determined using Folin-Cioucalteu method and calculated as gallic acid equivalents (GAE). The antioxidant activity of G. fisheri extract was performed via 2, 2-diphenyl-1- picrylhydrazyl (DPPH) free radical scavenging assay and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging capacity assays. The findings exhibited a strong correlation between antioxidant activity and the total phenol contents. In addition, DPPH and ABTS assays showed that G. fisheri extract showed antioxidant activities as a concentration-dependent manner. The IC50 values of G. fisheri extract were 902.19 μg/mL ± 0.785 and 727.98 μg/mL ± 0.822 for DPPH and ABTS, respectively. Vitamin C was used as a positive control in DPPH assay, while Trolox was used as a positive control in ABTS assay. To conclude, G. fisheri extract consists of a high amount of total phenolic content, which exhibit a significant antioxidant activity. However, further investigation regarding antioxidant activity should be performed in order to identify the mechanism of Gracilaria fisheri action. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ABTS%20assay" title="ABTS assay">ABTS assay</a>, <a href="https://publications.waset.org/abstracts/search?q=DPPH%20assay" title=" DPPH assay"> DPPH assay</a>, <a href="https://publications.waset.org/abstracts/search?q=sulfated%20polysaccharides" title=" sulfated polysaccharides"> sulfated polysaccharides</a>, <a href="https://publications.waset.org/abstracts/search?q=total%20phenolic%20content" title=" total phenolic content"> total phenolic content</a> </p> <a href="https://publications.waset.org/abstracts/140926/antioxidant-activity-of-gracilaria-fisheri-extract" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/140926.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">197</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7276</span> Effect of Ocimum americanum Water Extract on Antioxidant System in Rat </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Pornrut%20Rabintossaporn">Pornrut Rabintossaporn</a>, <a href="https://publications.waset.org/abstracts/search?q=Suphaket%20Saenthaweesuk"> Suphaket Saenthaweesuk</a>, <a href="https://publications.waset.org/abstracts/search?q=Amornnat%20Thuppia"> Amornnat Thuppia</a>, <a href="https://publications.waset.org/abstracts/search?q=Nuntiya%20Somparn"> Nuntiya Somparn </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Several dietary and herbal plants have been shown to possess cytoprotective and antioxidant effects with various mechanisms of action. The aim of this study was to determine the antioxidant effects and its mechanism of aqueous leaves extract of Ocimum americanum (OA), commonly known as American basil or 'hoary basil', in rat. The extract was screened for its phytochemical contents and antioxidant activity in vitro. Moreover, the extract was studied in rats to evaluate its effects in vivo. Rats were orally administered with the extract at the dose of 100, 200 and 400 mg/kg for 28 days. Phytochemical screening of plant extracts revealed the presence of alkaloid, cardiac glycosides, tannin and steroid compounds. The extract contained phenolic compounds 36.91 ± 0.66 mg of gallic acid equivalents per gram OA extract. The free radical scavenging activity assessed by DPPH assay gave IC50 of 41.27 ± 1.86 µg/mL, which is relatively lower than that of BHT with IC50 of 12.34 ± 1.14µg/mL. In the animals, the extract was well tolerated by the animals throughout the 28 days of study as shown by normal serum levels AST, ALP, ALT, BUN and Cr as well as normal histology of liver and pancreatic and kidney tissue. The protein expression of antioxidant enzymes, γ-glutamylcysteine ligase (γ-GCL) in liver was significantly increased compared with normal control. Consistent with the induction of γ-GCL protein expression significantly reduction of serum oxidative stress marker malondialdehyde (MDA) was found in rat treated with OA extract compared with control. Taken together, this study provides evidence that Ocimum americanum exhibits direct antioxidant properties and can induce cytoprotective enzyme in vivo. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title="antioxidant">antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=%CE%B3-glutamylcysteine%20ligase" title=" γ-glutamylcysteine ligase"> γ-glutamylcysteine ligase</a>, <a href="https://publications.waset.org/abstracts/search?q=MDA" title=" MDA"> MDA</a>, <a href="https://publications.waset.org/abstracts/search?q=Ocimum%20americanum" title=" Ocimum americanum"> Ocimum americanum</a> </p> <a href="https://publications.waset.org/abstracts/69529/effect-of-ocimum-americanum-water-extract-on-antioxidant-system-in-rat" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/69529.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">245</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7275</span> Antimicrobial Action and Its Underlying Mechanism by Methanolic Seed Extract of Syzygium cumini on Bacillus subtilis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alok%20Kumar%20Yadav">Alok Kumar Yadav</a>, <a href="https://publications.waset.org/abstracts/search?q=Saurabh%20Saraswat"> Saurabh Saraswat</a>, <a href="https://publications.waset.org/abstracts/search?q=Preeti%20Sirohi"> Preeti Sirohi</a>, <a href="https://publications.waset.org/abstracts/search?q=Manjoo%20Rani"> Manjoo Rani</a>, <a href="https://publications.waset.org/abstracts/search?q=Sameer%20Srivastava"> Sameer Srivastava</a>, <a href="https://publications.waset.org/abstracts/search?q=Manish%20Pratap%20Singh"> Manish Pratap Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Nand%20K.%20Singh"> Nand K. Singh </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The development of antibiotic resistance in bacteria is increasing at an alarming rate, and this is considered as one of the most serious threats in the history of medicine, and an alternative solution should be derived so as to tackle this problem. In many countries, people use the medicinal plants for the treatment of various diseases as these are cheaper, easily available and least toxic. Syzygium cumini is used for the treatment of various kinds of diseases but their mechanism of action is not reported. The antimicrobial activity of Syzygium cumini was tested by the well diffusion assay and zone of inhibition was reported to be 20.06 mm as compared to control with MIC of 0.3 mg/ml. Genomic DNA fragmentation of Bacillus subtilis revealed apoptosis and FE-SEM indicate cell wall cracking on several intervals of time. Propidium iodide staining results showed that few bacterial cells were stained in the control and population of stained cells increase after exposing them for various period of time. Flow cytometric kinetic data analysis on the membrane permeabilization in bacterial cell showed the significant contribution of antimicrobial potential of the seed extract on antimicrobial-induced permeabilization. Two components of Syzygium cumini methanolic seed extract was found to be quite active against four enzymes like PDB ID- 1W5D, 4OX3, 3MFD and 5E2F which have a very crucial role in membrane synthesis in Bacillus subtilis by in silico analysis. Through in silico analysis, lupeol showed highest binding energy for macromolecule 1W5D and 4OX3 whereas stigmasterol showed the highest binding energy for macromolecule 3MFD and 5E2F respectively. It showed that methanolic seed extract of Syzygium cumini can be used for the inhibition of foodborne infections caused by Bacillus subtilis and also as an alternative of prevalent antibiotics. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antibiotics" title="antibiotics">antibiotics</a>, <a href="https://publications.waset.org/abstracts/search?q=Bacillus%20subtilis" title=" Bacillus subtilis"> Bacillus subtilis</a>, <a href="https://publications.waset.org/abstracts/search?q=inhibition" title=" inhibition"> inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=Syzygium%20cumini" title=" Syzygium cumini"> Syzygium cumini</a> </p> <a href="https://publications.waset.org/abstracts/85752/antimicrobial-action-and-its-underlying-mechanism-by-methanolic-seed-extract-of-syzygium-cumini-on-bacillus-subtilis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85752.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">199</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7274</span> Bioavailability Enhancement of Ficus religiosa Extract by Solid Lipid Nanoparticles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanjay%20Singh">Sanjay Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Karunanithi%20Priyanka"> Karunanithi Priyanka</a>, <a href="https://publications.waset.org/abstracts/search?q=Ramoji%20Kosuru"> Ramoji Kosuru</a>, <a href="https://publications.waset.org/abstracts/search?q=Raju%20Prasad%20Sharma"> Raju Prasad Sharma</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Herbal drugs are well known for their mixed pharmacological activities with the benefit of no harmful side effects. The use of herbal drugs is limited because of their higher dose requirement, frequent drug administration, poor bioavailability of phytochemicals and delayed onset of action. Ficus religiosa, a potent anti-oxidant plant useful in the treatment of diabetes and cancer was selected for the study. Solid lipid nanoparticles (SLN) of Ficus religiosa extract was developed for the enhancement in oral bioavailability of stigmasterol and β-sitosterol-d-glucoside, principal components present in the extract. Hot homogenization followed by ultrasonication method was used to develop extract loaded SLN. Developed extract loaded SLN were characterized for particle size, PDI, zeta potential, entrapment efficiency, in vitro drug release and kinetics, fourier transform infra-red spectroscopy, differential scanning calorimetry, powder X-ray diffractrometry and stability studies. Entrapment efficiency of optimized extract loaded SLN was found to be 68.46 % (56.13 % of stigmasterol and 12.33 % of β-sitosteryl-d-glucoside, respectively). RP HPLC method development was done for simultaneous estimation of stigmasterol and β-sitosterol-d-glucoside in Ficus religiosa extract in rat plasma. Bioavailability studies were carried out for extract in suspension form and optimized extract loaded SLN. AUC of stigmasterol and β-sitosterol-d-glucoside were increased by 6.7-folds by 9.2-folds, respectively in rats treated with extract loaded SLN compared to extract suspension. Also, Cmax of stigmasterol and β-sitosterol-d-glucoside were increased by 4.3-folds by 3.9-folds, respectively in rats treated with extract loaded SLN compared to extract suspension. Mean residence times (MRT) for stigmasterol were found to be 12.3 ± 0.67 hours from extract and 7.4 ± 2.1 hours from SLN and for β-sitosterol-d-glucoside, 10.49 ± 2.9 hours from extract and 6.4 ± 0.3 hours from SLN. Hence, it was concluded that SLN enhanced the bioavailability and reduced the MRT of stigmasterol and β-sitosterol-d-glucoside in Ficus religiosa extract which in turn may lead to reduction in dose of Ficus religiosa extract, prolonged duration of action and also enhanced therapeutic efficacy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ficus%20religiosa" title="Ficus religiosa">Ficus religiosa</a>, <a href="https://publications.waset.org/abstracts/search?q=phytosterolins" title=" phytosterolins"> phytosterolins</a>, <a href="https://publications.waset.org/abstracts/search?q=bioavailability" title=" bioavailability"> bioavailability</a>, <a href="https://publications.waset.org/abstracts/search?q=solid%20lipid%20nanoparticles" title=" solid lipid nanoparticles"> solid lipid nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=stigmasterol%20and%20%CE%B2-sitosteryl-d-glucoside" title=" stigmasterol and β-sitosteryl-d-glucoside"> stigmasterol and β-sitosteryl-d-glucoside</a> </p> <a href="https://publications.waset.org/abstracts/17390/bioavailability-enhancement-of-ficus-religiosa-extract-by-solid-lipid-nanoparticles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17390.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">473</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7273</span> Patterns of Positive Feedback Formation in the System of Online Action</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=D.%20Gvozdikov">D. Gvozdikov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The purpose of this study is an attempt to describe an online action as a system that combines disjointed events and behavioral chains into a whole. The research focuses on patterns of naturally-formed chains of actions united by an orientation towards the online environment. A key characteristic of the system of online action is that it acts as an attractor for separate actions and chains of behavioral repertoire accumulating time and efforts made by users. The article demonstrates how the chains of online-offline actions are combined into a single pattern due to a simple identifiable mechanism, a positive feedback system. Using methods of digital ethnography and analyzing the content of the Instagram application and media blogs, the research reveals how through the positive feedback mechanism the entire system of online action acquires stability and can expand involving new spheres of human activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=digital%20anthropology" title="digital anthropology">digital anthropology</a>, <a href="https://publications.waset.org/abstracts/search?q=internet%20studies" title=" internet studies"> internet studies</a>, <a href="https://publications.waset.org/abstracts/search?q=systems%20theory" title=" systems theory"> systems theory</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20media" title=" social media"> social media</a> </p> <a href="https://publications.waset.org/abstracts/100749/patterns-of-positive-feedback-formation-in-the-system-of-online-action" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/100749.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">133</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7272</span> Aristotle's Notion of Akratic Action through the Prism of Moral Psychology</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Manik%20Konch">Manik Konch</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Actions are generally evaluated from moral point of view. Either the action is praised or condemned, but in all cases it involves the agent who performs it. The agent is held morally responsible for bringing out an action. This paper is an attempt to explore the Aristotle’s notion of action and its relation with moral development in response to modern philosophical moral psychology. Particularly, the distinction between voluntary, involuntary, and non-voluntary action in the Nicomachean Ethics with some basic problems from the perspective of moral psychology: the role of choice, moral responsibility, desire, and akrasia for an action. How to do a morally right action? Is there any role of virtue, character to do a moral action? These problems are analyzed and interpreted in order to show that the Aristotelian theory of action significantly contributes to the philosophical study of moral psychology. In this connection, the paper juxtaposes Aristotle’s theory of action with response from David Charles, John R. Searle’s, and Alfred Mele theorization of action in the mechanism of human moral behaviours. To achieve this addressed problem, we consider, how the recent moral philosophical moral psychology research can shed light on Aristotle's ethics by focusing on theory of action. In this connection, we argue that the desire is the only responsible for the akratic action. According to Aristotle, desire is primary source of action and it is the starting point of action and also the endpoint of an action. Therefore we are trying to see how desire can make a person incontinent and motivate to do such irrational actions. Is there any causes which we can say such actions are right or wrong? To measure an action we have need to see the consequences such act. Thus, we discuss the relationship between akrasia and action from the perspective of contemporary moral psychologists and philosophers whose are currently working on it. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=action" title="action">action</a>, <a href="https://publications.waset.org/abstracts/search?q=desire" title=" desire"> desire</a>, <a href="https://publications.waset.org/abstracts/search?q=moral%20psychology" title=" moral psychology"> moral psychology</a>, <a href="https://publications.waset.org/abstracts/search?q=Aristotle" title=" Aristotle"> Aristotle</a> </p> <a href="https://publications.waset.org/abstracts/55260/aristotles-notion-of-akratic-action-through-the-prism-of-moral-psychology" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/55260.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">260</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7271</span> Antimicrobial Activity of the Natural Products Derived from Phyllanthus Emblica and Gracilaria Fisheri Against Staphylococcus Aureus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Woraprat%20Amnuaychaichana">Woraprat Amnuaychaichana</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Several medicinal plants are well known to contain active constituents such as flavonoids and phenolic compounds with are plausible candidates for therapeutic purposes. An infectious disease caused by microbial infection is the leading cause of death. Antibiotics are typically used to eradicate these microbes, but recent evidence indicates that they are developing antibiotic-resistant effects. This study focused on antimicrobial activities of Phyllanthus emblica and Gracilaria fisheri using the agar disk diffusion method and broth microdilution to determine the minimum inhibitory concentration (MIC) value. The extracts were screened against Staphylococcus aureus. Five concentrations of plant extracts were used to determine the minimum inhibitory concentration (MIC) by 2-fold dilution of plant extract. The results indicated that G. fisheri extract gave the maximum zones of inhibition of 11.7 mm against S. aureus while P. emblica showed no effects. The MIC values of G. fisheri extract against S. aureus was 500 µg/ml. To summarise, G. fisheri extracts demonstrated high efficacy of antibacterial activity against Gram-positive S. aureus, which may pave the way for developing a formulation containing this plant. G. fisheri extract should be subjected to additional investigation in order to determine the mechanism of action of its antimicrobial activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antibacterial%20activity" title="antibacterial activity">antibacterial activity</a>, <a href="https://publications.waset.org/abstracts/search?q=Staphylococcus%20aureus" title=" Staphylococcus aureus"> Staphylococcus aureus</a>, <a href="https://publications.waset.org/abstracts/search?q=gracilaria%20fishery" title=" gracilaria fishery"> gracilaria fishery</a>, <a href="https://publications.waset.org/abstracts/search?q=Phyllanthus%20emblica" title=" Phyllanthus emblica"> Phyllanthus emblica</a> </p> <a href="https://publications.waset.org/abstracts/141049/antimicrobial-activity-of-the-natural-products-derived-from-phyllanthus-emblica-and-gracilaria-fisheri-against-staphylococcus-aureus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141049.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">188</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7270</span> Efficacy of Ethanolic Extract of Aerva javanica Aerial Parts in the Amelioration of CCl4-Induced Hepatotoxicity and Oxidative Damage in Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20K.%20Parvez">Mohammad K. Parvez</a>, <a href="https://publications.waset.org/abstracts/search?q=Ahmed%20H.%20Arbab"> Ahmed H. Arbab</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20S.%20Al-Dosari"> Mohammed S. Al-Dosari</a>, <a href="https://publications.waset.org/abstracts/search?q=Adnan%20J.%20Al-Rehaily"> Adnan J. Al-Rehaily</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We investigated ex vivo and in vivo antioxidative and hepatoprotective effect of Aerva javanica. Total ethanol extract of A. javanica aerial parts was prepared, and tested on DCFH-toxicated HepG2 cell in CCl4-injured Wistar rats. MTT-assay was used to determine cell viability, and serum biochemical markers of liver injury as well as histopathology were performed. In vitro DPPH and β-carotene free-radical scavenging assay and phytochemical screening of the extract was done. Furthermore, A. javanica total extract was standardized and validated by HPTLC method. While DCFH-injured cells were recovered to about 56.7% by 100 microg/ml of the extract, a 200 microg/ml dose resulted in hepatocytes recovery by about 90.2%. Oral administration of the extract (100 and 200 mg/kg.bw/day) significantly normalized the serum SGOT, SGPT, GGT, ALP, bilirubin, cholesterol, HDL, LDL, VLDL, TG and MDA levels, including tissue NP-SH and TP in CCl4-injured rats. In addition, the histopathology of dissected liver also revealed that A. javanica cured the tissue lesion compared to reference drug, Silymarin. In vitro assays revealed strong free-radical scavenging ability of the extract and presence of alkaloids, flavonoids, tannins, sterols and saponins where Rutin, a well-known antioxidant flavonoid was identified. Our finding therefore, suggests the therapeutic potential of A. javanica in various liver diseases. However, isolation of the active principles, their mechanism of action and other therapeutic contribution remain to be addressed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aerva%20javanica" title="Aerva javanica">Aerva javanica</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=hepatoprotection" title=" hepatoprotection"> hepatoprotection</a>, <a href="https://publications.waset.org/abstracts/search?q=rutin" title=" rutin"> rutin</a> </p> <a href="https://publications.waset.org/abstracts/46694/efficacy-of-ethanolic-extract-of-aerva-javanica-aerial-parts-in-the-amelioration-of-ccl4-induced-hepatotoxicity-and-oxidative-damage-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46694.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">295</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7269</span> Antioxidative Effect of Bauhinia acuminata Water Extract Consumption in Rat</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amornnat%20Thuppia">Amornnat Thuppia</a>, <a href="https://publications.waset.org/abstracts/search?q=Pornrut%20Rabintossaporn"> Pornrut Rabintossaporn</a>, <a href="https://publications.waset.org/abstracts/search?q=Suphaket%20Saenthaweesuk"> Suphaket Saenthaweesuk</a>, <a href="https://publications.waset.org/abstracts/search?q=Nuntiya%20Somparn"> Nuntiya Somparn</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this present study was to determine the antioxidant effects and its mechanism of aqueous leaves extract of Bauhinia acuminata (BA) in rat. The extract was screened for its phytochemical contents and antioxidant activity in vitro. Moreover, the extract was studied in rats to evaluate its effects in vivo. Rats were orally administered with the extract at the dose of 50, 100 and 200 mg/kg for 28 days. Phytochemical screening of plant extracts showed the presence of saponin, alkaloid, cardiac glycosides, flavonoids, tannin and steroid compounds. The extract contained phenolic compounds 53.36 ± 1.01 mg of gallic acid equivalents per gram BA extract. The free radical scavenging activity assessed by DPPH assay gave IC50 of 44.47 ± 2.83 µg/mL, which is relatively lower than that of BHT with IC50 of 12.34 ± 1.14µg/mL. In the animals, the extract was well tolerated by the animals throughout the 28 days of study as shown by normal serum levels AST, ALP, ALT, BUN and Cr as well as normal histology of liver and pancreatic and kidney tissue. Significantly, reduction of serum oxidative stress markers malondialdehyde (MDA) was found in rat treated with BA extract compared with control. Taken together, this study provides evidence that Bauhinia acuminata (BA) exhibits direct antioxidant properties and induces cytoprotective enzyme in vivo. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bauhinia%20acuminata" title="Bauhinia acuminata">Bauhinia acuminata</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=malondialdehyde%20%28MDA%29" title=" malondialdehyde (MDA)"> malondialdehyde (MDA)</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative%20marker" title=" oxidative marker"> oxidative marker</a> </p> <a href="https://publications.waset.org/abstracts/69547/antioxidative-effect-of-bauhinia-acuminata-water-extract-consumption-in-rat" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/69547.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">273</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7268</span> Identification of the Antimicrobial Effect of Liquorice Extracts on Gram-Positive Bacteria: Determination of Minimum Inhibitory Concentration and Mechanism of Action Using a luxABCDE Reporter Strain</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Madiha%20El%20Awamie">Madiha El Awamie</a>, <a href="https://publications.waset.org/abstracts/search?q=Catherine%20Rees"> Catherine Rees</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Natural preservatives have been used as alternatives to traditional chemical preservatives; however, a limited number have been commercially developed and many remain to be investigated as sources of safer and effective antimicrobials. In this study, we have been investigating the antimicrobial activity of an extract of <em>Glycyrrhiza glabra</em> (liquorice) that was provided as a waste material from the production of liquorice flavourings for the food industry, and to investigate if this retained the expected antimicrobial activity so it could be used as a natural preservative. Antibacterial activity of liquorice extract was screened for evidence of growth inhibition against eight species of Gram-negative and Gram-positive bacteria, including <em>Listeria monocytogenes, Listeria innocua, Staphylococcus aureus, Enterococcus faecalis</em> and <em>Bacillus subtilis</em>. The Gram-negative bacteria tested include <em>Pseudomonas aeruginosa, Escherichia coli </em>and<em> Salmonella typhimurium</em> but none of these were affected by the extract. In contrast, for all of the Gram-positive bacteria tested, growth was inhibited as monitored using optical density. However parallel studies using viable count indicated that the cells were not killed meaning that the extract was bacteriostatic rather than bacteriocidal. The Minimum Inhibitory Concentration [MIC] and Minimum Bactericidal Concentration [MBC] of the extract was also determined and a concentration of 50 µg ml<sup>-1</sup> was found to have a strong bacteriostatic effect on Gram-positive bacteria. Microscopic analysis indicated that there were changes in cell shape suggesting the cell wall was affected. In addition, the use of a reporter strain of <em>Listeria</em> transformed with the bioluminescence genes <em>luxABCDE</em> indicated that cell energy levels were reduced when treated with either 12.5 or 50 µg ml<sup>-1</sup> of the extract, with the reduction in light output being proportional to the concentration of the extract used. Together these results suggest that the extract is inhibiting the growth of Gram-positive bacteria only by damaging the cell wall and/or membrane. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antibacterial%20activity" title="antibacterial activity">antibacterial activity</a>, <a href="https://publications.waset.org/abstracts/search?q=bioluminescence" title=" bioluminescence"> bioluminescence</a>, <a href="https://publications.waset.org/abstracts/search?q=Glycyrrhiza%20glabra" title=" Glycyrrhiza glabra"> Glycyrrhiza glabra</a>, <a href="https://publications.waset.org/abstracts/search?q=natural%20preservative" title=" natural preservative"> natural preservative</a> </p> <a href="https://publications.waset.org/abstracts/48797/identification-of-the-antimicrobial-effect-of-liquorice-extracts-on-gram-positive-bacteria-determination-of-minimum-inhibitory-concentration-and-mechanism-of-action-using-a-luxabcde-reporter-strain" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/48797.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">340</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7267</span> Aqueous Extract of Picrorrhiza kurroa Royle ex Benth: A Potent Inhibitor of Human Topoisomerases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Syed%20Asif%20Hassan">Syed Asif Hassan</a>, <a href="https://publications.waset.org/abstracts/search?q=Ritu%20Barthwal"> Ritu Barthwal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Topoisomerase I and II α plays a crucial role in the DNA-maintenance in all living cells, and for this reason, inhibitors of this enzyme have been much studied. In this paper, we have described the inhibitory effect of the aqueous extract of Picrorrhiza kurroa on human topoisomerases by measuring the relaxation of superhelical plasmid pBR322 DNA. The aqueous extract inhibited topoisomerase I and II α in a concentration-dependent manner (Inhibitory concentration (IC) ≈ 25 and 50 µg, respectively). By stabilization studies of topoisomerase I-DNA complex and preincubation studies of topoisomerase I and II α with the extract; we conclude that the possible mechanism of inhibition is both; 1) stabilization of covalent complex of topo I-DNA complex and 2) direct inhibition of the enzyme topoisomerases. These findings might explain the antineoplastic activity of Picrorrhiza kurroa and encourage new studies to elucidate the usefulness of the extract as a potent antineoplastic agent. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Picrorrhiza%20kurroa" title="Picrorrhiza kurroa">Picrorrhiza kurroa</a>, <a href="https://publications.waset.org/abstracts/search?q=topoisomerase%20I%20and%20II%20%CE%B1" title=" topoisomerase I and II α"> topoisomerase I and II α</a>, <a href="https://publications.waset.org/abstracts/search?q=inhibition" title=" inhibition"> inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=antineoplastic%20agent" title=" antineoplastic agent"> antineoplastic agent</a> </p> <a href="https://publications.waset.org/abstracts/65175/aqueous-extract-of-picrorrhiza-kurroa-royle-ex-benth-a-potent-inhibitor-of-human-topoisomerases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/65175.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">340</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7266</span> Triggering Apoptosis to Uproot Breast Cancer: HPLC-MS/MS Profiling, in-vitro and in-silico Fascinating Results of Polyphenolics in Pomegranate Rind Extract</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alaa%20M.%20Badr%20Eldin">Alaa M. Badr Eldin</a>, <a href="https://publications.waset.org/abstracts/search?q=Mayar%20M.%20Shahen"> Mayar M. Shahen</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20S.%20Sedeek"> Mohammed S. Sedeek</a>, <a href="https://publications.waset.org/abstracts/search?q=Marwa%20I.%20Ezzat"> Marwa I. Ezzat</a>, <a href="https://publications.waset.org/abstracts/search?q=Sawsan%20M.%20ElSonbaty"> Sawsan M. ElSonbaty</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammed%20A.%20Saad"> Muhammed A. Saad</a>, <a href="https://publications.waset.org/abstracts/search?q=Manal%20S.%20Afifi"> Manal S. Afifi</a>, <a href="https://publications.waset.org/abstracts/search?q=Omar%20M.%20Sabry"> Omar M. Sabry</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Using HPLC-MS/MS technique, 133 polyphenolic compounds were identified in the methanol extract of pomegranate rind (Punica granatum L.). In-vitro cytotoxic activity against breast cancer cell line MCF-7 was investigated, with an IC50 of 54 ug/ml. In-silico molecular docking using ellagic acid, gallagic acid, and Punicalagin as model compounds identified in pomegranate rind extract confirmed the intriguing anti-estrogenic action of the key polyphenolic components in pomegranate rind extract. Surprisingly, taxol showed low activity compared to pomegranate compounds as ERα antagonist and ERβ agonist. Pomegranate rind extract enhanced apoptosis of breast cancer cells through upregulation of the caspase-3 expression and downregulation of NF-κB transcription factor. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=HPLC-MS%2FMS" title="HPLC-MS/MS">HPLC-MS/MS</a>, <a href="https://publications.waset.org/abstracts/search?q=pomegranate%20rind" title=" pomegranate rind"> pomegranate rind</a>, <a href="https://publications.waset.org/abstracts/search?q=cytotoxicity" title=" cytotoxicity"> cytotoxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=MCF-7" title=" MCF-7"> MCF-7</a>, <a href="https://publications.waset.org/abstracts/search?q=ER" title=" ER"> ER</a>, <a href="https://publications.waset.org/abstracts/search?q=caspase-3" title=" caspase-3"> caspase-3</a>, <a href="https://publications.waset.org/abstracts/search?q=NF-kB" title=" NF-kB"> NF-kB</a> </p> <a href="https://publications.waset.org/abstracts/163413/triggering-apoptosis-to-uproot-breast-cancer-hplc-msms-profiling-in-vitro-and-in-silico-fascinating-results-of-polyphenolics-in-pomegranate-rind-extract" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163413.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">116</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7265</span> Impact of Ethnomedicinal Plants on Toothpaste Improvement</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Muna%20Jalal%20Ali">Muna Jalal Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Essam%20A.%20Makky"> Essam A. Makky</a>, <a href="https://publications.waset.org/abstracts/search?q=Mashitah%20M.%20Yusoff"> Mashitah M. Yusoff</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objectives: The aim of this study to evaluate the antimicrobial susceptibility of combined toothpaste with medicinal plants and the relations between the commercial toothpaste to its price and the patient age as well. Materials and Methods: Oral isolates of different patients aged 3 to 60 years were obtained, purified, and tested against four different ethnomedicinal plant extracts for antimicrobial activity. A total of 10 different commercial toothpastes (different brands and prices) were collected from the market, and the combined action of the medicinal plants and toothpaste was studied. Results: We found a higher bacterial population in the age group of 3–40 years than the group of 40–60 years, with approximately 44% and 32%, respectively. The combined action of ethanolic extract (alone) against oral isolates showed a synergistic effect, with 32.20, 30.50, and 25.42% for combinations A (Ci/Ca), B (Ci/Ca/P), and C (Ci/Ca/P/N), respectively. By contrast, the combined action of ethnomedicinal plants with 10 different toothpastes improved the antimicrobial sensitivity by 60, 100, and 0% for combinations A, B, and C respectively. Clinical relevance: The ethanolic extract of only combinations A and B with commercial toothpaste showed high antibacterial activity against oral isolates and the effectiveness of toothpaste is not related to the price. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=microbial%20evolution" title="microbial evolution">microbial evolution</a>, <a href="https://publications.waset.org/abstracts/search?q=oral%20isolates" title=" oral isolates"> oral isolates</a>, <a href="https://publications.waset.org/abstracts/search?q=ethnomedicinal%20plants" title=" ethnomedicinal plants"> ethnomedicinal plants</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20activity" title=" antimicrobial activity"> antimicrobial activity</a>, <a href="https://publications.waset.org/abstracts/search?q=toothpaste" title=" toothpaste"> toothpaste</a> </p> <a href="https://publications.waset.org/abstracts/53260/impact-of-ethnomedicinal-plants-on-toothpaste-improvement" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/53260.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">314</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7264</span> Inhibition of the Corrosion of Copper in 0.5 NaCl Solutions by Aqueous Extract and Hydrolysis Acid of Olive Leaf Extract</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chahla%20Rahal">Chahla Rahal</a>, <a href="https://publications.waset.org/abstracts/search?q=Philippe%20Refait"> Philippe Refait</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Oleuropein-rich extract from olive leaf and acid hydrolysates, rich in hydroxytyrosol and elenolic acid was prepared under different experimental conditions. These phenolic compounds may be used as a corrosion inhibitor. The inhibitive action of these extracts and its major constituents on the corrosion of copper in 0.5 M NaCl solution has been evaluated by potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and weight loss measurements. The product of extraction was analyzed with high performance liquid chromatography (HPLC), whose analysis shows that olive leaf extract are greatly rich in phenolic compounds, mainly Oleuropeine (OLE), Hydroxytyrosol (HT) and elenolic acid (EA). After the acid hydrolysis and high temperature of extraction, an increase in hydroxytyrosol concentration was detected, coupled with relatively low oleuropeine content and high concentration of elenolic acid. The potentiodynamic measurements have shown that this extract acts as a mixed-type corrosion inhibitor, and good inhibition efficiency is observed with the increase in HT and EA concentration. These results suggest that the inhibitive effect of olive leaf extract might be due to the adsorption of the various phenolic compounds onto the copper surface. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=olive%20leaf%20extract" title="olive leaf extract">olive leaf extract</a>, <a href="https://publications.waset.org/abstracts/search?q=oleuropein" title=" oleuropein"> oleuropein</a>, <a href="https://publications.waset.org/abstracts/search?q=voltammetry" title=" voltammetry"> voltammetry</a>, <a href="https://publications.waset.org/abstracts/search?q=copper" title=" copper"> copper</a>, <a href="https://publications.waset.org/abstracts/search?q=corrosion" title=" corrosion"> corrosion</a>, <a href="https://publications.waset.org/abstracts/search?q=HPLC" title=" HPLC"> HPLC</a>, <a href="https://publications.waset.org/abstracts/search?q=EIS" title=" EIS"> EIS</a> </p> <a href="https://publications.waset.org/abstracts/61014/inhibition-of-the-corrosion-of-copper-in-05-nacl-solutions-by-aqueous-extract-and-hydrolysis-acid-of-olive-leaf-extract" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61014.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">302</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7263</span> Effect Mechanisms of Aromatic Plants: Effects on Intestinal Health and Broiler Feeding</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ozlem%20Durna%20Aydin">Ozlem Durna Aydin</a>, <a href="https://publications.waset.org/abstracts/search?q=Gultekin%20Yildiz"> Gultekin Yildiz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Antibiotics are microbial metabolites with low molecular weight produced by fungi and algae, inhibiting the development of other microorganisms even in low growth. Antibiotics have been used as growth factors in animal feeds for many years. They prohibited; because of increased residue problem and increased resistance to antibiotics in bacteria due to prolonged use. Aromatic plants and extracts have attracted the attention of scientists nowadays due to positive reasons such as confidence of the community to the products those are coming from nature, desire to consume, and no residue problems. Plant extracts are obtained from aromatic plants, and they come forward with antifungal, antibacterial, antiviral, antioxidant and antilipidemic properties. It has been stated that intestinal histomorphology and microbiosis are positively affected by the use of plant extract in feeds. In the present day, aromatic plants and extracts are a remarkable research field with intriguing unknowns in the field of animal nutrition, and they continue to exist in the journal in vitro and in vivo studies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aromatic%20plant" title="aromatic plant">aromatic plant</a>, <a href="https://publications.waset.org/abstracts/search?q=broilers" title=" broilers"> broilers</a>, <a href="https://publications.waset.org/abstracts/search?q=extract%20mechanism%20of%20action" title=" extract mechanism of action"> extract mechanism of action</a>, <a href="https://publications.waset.org/abstracts/search?q=intestinal%20health" title=" intestinal health"> intestinal health</a> </p> <a href="https://publications.waset.org/abstracts/85014/effect-mechanisms-of-aromatic-plants-effects-on-intestinal-health-and-broiler-feeding" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85014.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">166</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7262</span> Phytochemical Screening, and Antimicrobial Evaluation of Bioactive Compounds from Red Millipede (Trigoniulus corallinus)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Y.%20B.%20Idris">Y. B. Idris</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Sirajo"> M. Sirajo</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20G.%20Hassan"> L. G. Hassan</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Izuagie"> T. Izuagie</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Muktar"> T. Muktar</a>, <a href="https://publications.waset.org/abstracts/search?q=I.%20Lawal"> I. Lawal</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20U.%20Abubakar"> A. U. Abubakar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study investigates the extraction, phytochemical composition, and antimicrobial activity of bioactive compounds from red millipedes using three different solvents: n-Hexane, Chloroform, and Methanol. The largest yield was obtained from the methanol extract, which had percentage yields of 0.8%, 2.2%, and 5.6%, respectively. Terpenoids and sterols were found in all extracts according to preliminary zoochemical screening, but only the methanol extract included saponins and phenols. With a maximum zone of inhibition of 9 mm at 1000 µg/ml, antimicrobial susceptibility tests revealed that the methanol extract had the strongest antibacterial activity, especially against Escherichia coli and Staphylococcus aureus. Significant activity was also shown by the n-hexane extract, although the chloroform extract had only mild antibacterial activity. Tests for minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) verified that the methanol extract was more effective than the other extracts, particularly against S. aureus and S. typhi. None of the extracts, nonetheless, showed any discernible antifungal action. The potential of red millipede extracts, especially those based on methanol, as a source of antimicrobial chemicals for use in the future is highlighted by this work. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=millipedes" title="millipedes">millipedes</a>, <a href="https://publications.waset.org/abstracts/search?q=defensive%20extraction" title=" defensive extraction"> defensive extraction</a>, <a href="https://publications.waset.org/abstracts/search?q=antibacterial" title=" antibacterial"> antibacterial</a>, <a href="https://publications.waset.org/abstracts/search?q=antifungal" title=" antifungal"> antifungal</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial" title=" antimicrobial"> antimicrobial</a>, <a href="https://publications.waset.org/abstracts/search?q=minimum%20inhibitory%20concentration%20%28MIC%29" title=" minimum inhibitory concentration (MIC)"> minimum inhibitory concentration (MIC)</a>, <a href="https://publications.waset.org/abstracts/search?q=minimum%20bacterial%20concentration%20%28MBC%29" title=" minimum bacterial concentration (MBC)"> minimum bacterial concentration (MBC)</a> </p> <a href="https://publications.waset.org/abstracts/192970/phytochemical-screening-and-antimicrobial-evaluation-of-bioactive-compounds-from-red-millipede-trigoniulus-corallinus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/192970.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">12</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7261</span> Phytochemical Screening and Toxicological Studies of Aqueous Stem Bark Extract of Boswellia papyrifera (DEL) in Albino Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Y.%20Abdulmumin">Y. Abdulmumin</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20I.%20Matazu"> K. I. Matazu</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20M.%20Wudil"> A. M. Wudil</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20J.%20Alhassan"> A. J. Alhassan</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20A.%20Imam"> A. A. Imam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Phytochemical analysis of Boswellia papryfera confirms the presence of various phytochemicals such as alkaloids, flavonoids, tannins, saponins and cardiac glycosides in its aqueous stem bark extract at different concentration, with tannins being the highest (0.611 ± 0.002 g %). Acute toxicity test (LD50,oral, rat) of the extract showed no mortality at up to 5000 mg/kg and the animals were found active and healthy. The extract was declared as practically non-toxic, this suggest the safety of the extract in traditional medicine. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acute%20toxicity" title="acute toxicity">acute toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=aqueous%20extract" title=" aqueous extract"> aqueous extract</a>, <a href="https://publications.waset.org/abstracts/search?q=boswellia%20papryfera" title=" boswellia papryfera"> boswellia papryfera</a>, <a href="https://publications.waset.org/abstracts/search?q=phytochemicals" title=" phytochemicals"> phytochemicals</a>, <a href="https://publications.waset.org/abstracts/search?q=stem%20bark%20extract" title=" stem bark extract"> stem bark extract</a> </p> <a href="https://publications.waset.org/abstracts/34096/phytochemical-screening-and-toxicological-studies-of-aqueous-stem-bark-extract-of-boswellia-papyrifera-del-in-albino-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/34096.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">427</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7260</span> Antistress Effects of Hydrangeae Dulcis Folium on Net Handing Stress-Induced Anxiety-Like Behavior in Zebrafish: Possible Mechanism of Action of Adrenocorticotropin Hormone (ACTH) Receptor</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lee%20Seungheon">Lee Seungheon</a>, <a href="https://publications.waset.org/abstracts/search?q=Kim%20Ba-Ro"> Kim Ba-Ro</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, the anti-stress effects of the ethanolic extract of Hydrangeae Dulcis Folium (EHDF) were investigated. To determine the effects of EHDF on physical stress, changes in the whole-body cortisol level and behaviour were monitored in zebrafish. To induce physical stress, we used the net handling stress (NHS). Fish were treated with EHDF for 6 min before they were exposed to stress, and the fish were either evaluated via behavioural tests, including a novel tank test and an open field test or sacrificed to collect body fluid from the whole body. The results indicate that increased anxiety-like behaviours in the novel tank test and open field test under stress were recovered by treatment with EHDF at 5, 10 and 20 mg/L (P < 0.05). Moreover, compared with the normal group, which was not treated with NHS, the whole-body cortisol level was significantly increased by treatment with NHS in the control group. Compared with the control group, pre-treatment with EHDF at concentrations of 5, 10 and 20 mg/L for 6 min significantly prevented the increase in the whole-body cortisol level induced by NHS (P < 0.05). In addition, adrenocorticotropin hormone (ACTH) challenge studies showed that EHDF completely blocked the effects of ACTH (0.2 IU/g, IP) on cortisol secretion. These results suggest that EHDF may be a good anti-stress candidate and that its mechanism of action may be related to its positive effects on cortisol release. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=net%20handling%20stress" title="net handling stress">net handling stress</a>, <a href="https://publications.waset.org/abstracts/search?q=zebrafish" title=" zebrafish"> zebrafish</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrangeae%20dulcis%20folium" title=" hydrangeae dulcis folium"> hydrangeae dulcis folium</a>, <a href="https://publications.waset.org/abstracts/search?q=whole-body%20cortisol" title=" whole-body cortisol"> whole-body cortisol</a>, <a href="https://publications.waset.org/abstracts/search?q=novel%20tank%20test" title=" novel tank test"> novel tank test</a>, <a href="https://publications.waset.org/abstracts/search?q=open%20field%20test" title=" open field test"> open field test</a> </p> <a href="https://publications.waset.org/abstracts/63359/antistress-effects-of-hydrangeae-dulcis-folium-on-net-handing-stress-induced-anxiety-like-behavior-in-zebrafish-possible-mechanism-of-action-of-adrenocorticotropin-hormone-acth-receptor" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/63359.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">299</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7259</span> Protective Effect of the Standardized Extract of Holmskioldia sanguinea on Tumor Bearing Mice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mahesh%20Pal">Mahesh Pal</a>, <a href="https://publications.waset.org/abstracts/search?q=Tripti%20Mishra"> Tripti Mishra</a>, <a href="https://publications.waset.org/abstracts/search?q=Chandana%20Rao"> Chandana Rao</a>, <a href="https://publications.waset.org/abstracts/search?q=Dalip%20Upreti"> Dalip Upreti</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cancer has been considered to be a very dreadful disease. Holmskioldia sanguinea is a large climbing shrub found in the Himalayas at an altitude of 5,000 ft and preliminary investigation showed the excellent yield of andrographolide and subjected for the anticancer activity. Protective effect of Holmskioldia sanguinea leaf ethanolic extract has been investigated against Ehrlich ascites carcinoma (EAC) and Daltons ascites lymphoma (DAL) in Swiss albino mice to evaluate the possible mechanism of action. The enzymatic antioxidant status was studied on tumor bearing mice, which shows the potential of the compound to possess significant free radical scavenging property and revealed significant tumor regression and prolonged survival time. The isolated bioactive molecule andrographolide from Holmskioldia sanguinea yields (2.5%) in subject to HPTLC/HPLC analysis. The cellular defense system constituting the superoxide dismutase, catalyses was enhanced whereby the lipid peroxidation content was restricted to a larger extent. The Holmskioldia sanguinea is a new source of andrographolide and demonstrated the potency in treatment of cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Holmskioldia%20sanguinea" title="Holmskioldia sanguinea">Holmskioldia sanguinea</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor" title=" tumor"> tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=mice" title=" mice"> mice</a>, <a href="https://publications.waset.org/abstracts/search?q=andrographolide" title=" andrographolide"> andrographolide</a> </p> <a href="https://publications.waset.org/abstracts/69400/protective-effect-of-the-standardized-extract-of-holmskioldia-sanguinea-on-tumor-bearing-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/69400.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">263</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7258</span> Mechanism of in Vitro Inhibition of Alpha-Amylase, Alpha-Glucosidase by Ethanolic Extracts of Polyalthia Longifolia, Its in Vitro Cytotoxicity on L6, Vero Cell-Lines and Influence of Glucose Uptake by Rat Hemi-Diaphragm</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=P.%20Gayathri">P. Gayathri</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20P.%20Jeyanthi"> G. P. Jeyanthi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The bark of Polyalthia longifolia is used in ayurvedic system of medicine for the manangement of various ailments including diabetes mellitus. The bark of P. longifolia extracts was extracted using various polar and non-polar solvents and tested for inhibition of alpha-amylase and alpha-glucosidase among which the ethanolic extracts were found to be more potent. The ethanolic extracts of the bark were tested for the in vitro inhibition of alpha-amylase using starch as substrate and alpha-glucosidase using p-nitro phenyl alpha-D-gluco pyranoside as substrate to establish its in vitro antidiabetic effect. The mechanism of inhibition was determined by Dixon plot and Cornish-Bowden plot. The cytotoxic effect of the extract was tested on L6 and Vero cell-lines. The extract was partially purified by TLC. The individual effect of the ethanolic extract, TLC fractions and its combinatorial effect with insulin and glibenclamide on glucose uptake by rat hemi-diaphragm were studied.Results revealed that the ethanolic extracts of Polyalthia longifolia bark exhibited competitive inhibition of alpha-amylase and alpha-glucosidase. The extracts were also found not to be cytotoxic at the highest dose of 1 mg/mL. Glucose uptake study revealed that the extract alone and when combined with insulin, decreased the glucose uptake when compared to insulin control, however the purified TLC fractions exhibited significantly higher (p<0.05) glucose uptake by the rat hemi-diaphragm when compared to insulin. The study shows various possible mechanism of in vitro antidiabetic effect of the P. longifolia bark. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alpha-amylase" title="alpha-amylase">alpha-amylase</a>, <a href="https://publications.waset.org/abstracts/search?q=alpha-glucosidase" title=" alpha-glucosidase"> alpha-glucosidase</a>, <a href="https://publications.waset.org/abstracts/search?q=dixon" title=" dixon"> dixon</a>, <a href="https://publications.waset.org/abstracts/search?q=cornish-bowden" title=" cornish-bowden"> cornish-bowden</a>, <a href="https://publications.waset.org/abstracts/search?q=L6" title=" L6 "> L6 </a>, <a href="https://publications.waset.org/abstracts/search?q=Vero%20cell-lines" title=" Vero cell-lines"> Vero cell-lines</a>, <a href="https://publications.waset.org/abstracts/search?q=glucose%20uptake" title=" glucose uptake"> glucose uptake</a>, <a href="https://publications.waset.org/abstracts/search?q=polyalthia%20longifolia%20bark" title=" polyalthia longifolia bark"> polyalthia longifolia bark</a>, <a href="https://publications.waset.org/abstracts/search?q=ethanolic%20extract" title=" ethanolic extract"> ethanolic extract</a>, <a href="https://publications.waset.org/abstracts/search?q=TLC%20fractions" title=" TLC fractions"> TLC fractions</a> </p> <a href="https://publications.waset.org/abstracts/34899/mechanism-of-in-vitro-inhibition-of-alpha-amylase-alpha-glucosidase-by-ethanolic-extracts-of-polyalthia-longifolia-its-in-vitro-cytotoxicity-on-l6-vero-cell-lines-and-influence-of-glucose-uptake-by-rat-hemi-diaphragm" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/34899.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">469</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7257</span> Evaluation of Phytochemical and Antidiarrhoeal Activity of Butanol Fraction of Terminalia avicennioides Leaf in Swiss Albino Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fatima%20Mohammed%20Musa">Fatima Mohammed Musa</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20B.%20Ameh"> J. B. Ameh</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20A.%20Ado"> S. A. Ado</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20S.%20Olonitola"> O. S. Olonitola</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study was undertaken to evaluate the phytochemical constituents of extracts of Terminalia avicennioides leaf and the antidiarrhoeal effect of n-butanol fraction of the leaf extract in Swiss albino rats infected with Salmonella Typhimurium and Escherichia coli. Ethanol crude extract of Terminalia avicennioides leaf was dissolved in 1.5 liters of sterile distilled water. The extract solution was partitioned with 250 ml each of chloroform, ethyl acetate and n-butanol solvents (1:1v/v) to obtain soluble fractions from the extract. The leaf extract and its fractions were screened for the presence of phytocompounds using standard analytical methods. The antidirrhoeal activity of n-butanol fraction was evaluated in Swiss albino rats using standard methods. The results of phytochemical screening of extract of Terminalia avicennioides leaf and its fractions, revealed the presence of carbohydrates, alkaloids, tannins, flavonoids, saponins, steroids, triterpens, glycosides and phenols. The results of in vivo activity showed that 60 % of each group of rats infected with 2.0 x 108 cfu/ml viable cells of S. Typhimurium and 2.0 x109 cfu/ml viable cells of E. coli manifested the symptoms of diarrhoea, 72 hours after the rats were challenged with bacteria. Other symptoms observed among the infected animals included, loss of appetite, loss of weight, general body weakness and 40 % mortality in S. Typhimurium infected non treated group of rats. Similarly, 60 %, and 20 % mortality was observed among E. coli infected none treated and E. coli infected antibiotic (metronidazole) treated groups of rats respectively. However, there was a reduction in the number of infected rats defecating watery stools over time among all the infected rats that were treated with n-butanol fraction of the leaf extract and mortality was also not observed in the group, indicating high efficacy of n-butanol fraction of T. avicennioides leaf. The results also indicated that n-butanol can be used as alternative source of antidiarrhoeal agent in the treatment of diarrhoea caused by Salmonella Typhimurium and Escherichia coli. In the light of this, there is a need for further research on the mechanism of action of the candidate fraction of T. avicennioides leaf which could be responsible for the observed in vivo antibacterial activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antidirrhoeal%20effect" title="antidirrhoeal effect">antidirrhoeal effect</a>, <a href="https://publications.waset.org/abstracts/search?q=phytochemical%20constituents" title=" phytochemical constituents"> phytochemical constituents</a>, <a href="https://publications.waset.org/abstracts/search?q=swiss%20albino%20rats" title=" swiss albino rats"> swiss albino rats</a>, <a href="https://publications.waset.org/abstracts/search?q=terminalia%20avicennioides" title=" terminalia avicennioides"> terminalia avicennioides</a> </p> <a href="https://publications.waset.org/abstracts/80614/evaluation-of-phytochemical-and-antidiarrhoeal-activity-of-butanol-fraction-of-terminalia-avicennioides-leaf-in-swiss-albino-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/80614.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">381</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7256</span> Targeted Nano Anti-Cancer Drugs for Curing Cancers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Imran%20Ali">Imran Ali</a> </p> <p class="card-text"><strong>Abstract:</strong></p> General chemotherapy for cancer treatment has many side and toxic effects. A new approach of targeting nano anti-cancer drug is under development stage and only few drugs are available in the market today. The unique features of these drugs are targeted action on cancer cells only without any side effect. Sometimes, these are called magic drugs. The important molecules used for nano anti-cancer drugs are cisplatin, carboplatin, bleomycin, 5-fluorouracil, doxorubicin, dactinomycin, 6-mercaptopurine, paclitaxel, topotecan, vinblastin and etoposide etc. The most commonly used materials for preparing nano particles carriers are dendrimers, polymeric, liposomal, micelles inorganic, organic etc. The proposed lecture will comprise the-of-art of nano drugs in cancer chemo-therapy including preparation, types of drugs, mechanism, future perspectives etc. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cancer" title="cancer">cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=nano-anti-cancer%20drugs" title=" nano-anti-cancer drugs"> nano-anti-cancer drugs</a>, <a href="https://publications.waset.org/abstracts/search?q=chemo-therapy" title=" chemo-therapy"> chemo-therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=mechanism%20of%20action" title=" mechanism of action"> mechanism of action</a>, <a href="https://publications.waset.org/abstracts/search?q=future%20perspectives" title=" future perspectives"> future perspectives</a> </p> <a href="https://publications.waset.org/abstracts/32360/targeted-nano-anti-cancer-drugs-for-curing-cancers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/32360.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">447</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7255</span> Olive Leaf Extract as Natural Corrosion Inhibitor for Pure Copper in 0.5 M NaCl Solution: A Study by Voltammetry around OCP </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chahla%20Rahal">Chahla Rahal</a>, <a href="https://publications.waset.org/abstracts/search?q=Philippe%20Refait"> Philippe Refait </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Oleuropein-rich extract from olive leaf and acid hydrolysates, rich in hydroxytyrosol and elenolic acid was prepared under different experimental conditions. These phenolic compounds may be used as a corrosion inhibitor. The inhibitive action of these extracts and its major constituents on the corrosion of copper in 0.5 M NaCl solution has been evaluated by potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and weight loss measurements. The product of extraction was analyzed with high performance liquid chromatography (HPLC), whose analysis shows that olive leaf extract are greatly rich in phenolic compounds, mainly Oleuropeine (OLE), Hydroxytyrosol (HT) and elenolic acid (EA). After the acid hydrolysis and high temperature of extraction, an increase in hydroxytyrosol concentration was detected, coupled with relatively low oleuropeine content and high concentration of elenolic acid. The potentiodynamic measurements have shown that this extract acts as a mixed-type corrosion inhibitor, and good inhibition efficiency is observed with the increase in HT and EA concentration. These results suggest that the inhibitive effect of olive leaf extract might be due to the adsorption of the various phenolic compounds onto the copper surface. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Olive%20leaf%20extract" title="Olive leaf extract">Olive leaf extract</a>, <a href="https://publications.waset.org/abstracts/search?q=Oleuropein" title=" Oleuropein"> Oleuropein</a>, <a href="https://publications.waset.org/abstracts/search?q=hydroxytyrosol" title=" hydroxytyrosol"> hydroxytyrosol</a>, <a href="https://publications.waset.org/abstracts/search?q=elenolic%20acid" title=" elenolic acid "> elenolic acid </a>, <a href="https://publications.waset.org/abstracts/search?q=Copper" title=" Copper"> Copper</a>, <a href="https://publications.waset.org/abstracts/search?q=Corrosion" title=" Corrosion"> Corrosion</a>, <a href="https://publications.waset.org/abstracts/search?q=HPLC%2FDAD" title=" HPLC/DAD"> HPLC/DAD</a>, <a href="https://publications.waset.org/abstracts/search?q=Polarisation" title=" Polarisation"> Polarisation</a>, <a href="https://publications.waset.org/abstracts/search?q=EIS" title=" EIS"> EIS</a> </p> <a href="https://publications.waset.org/abstracts/61007/olive-leaf-extract-as-natural-corrosion-inhibitor-for-pure-copper-in-05-m-nacl-solution-a-study-by-voltammetry-around-ocp" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61007.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">257</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7254</span> Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Compounds from Bauhinia kockiana Korth and Their Mechanism of Antibacterial Activity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yik%20Ling%20Chew">Yik Ling Chew</a>, <a href="https://publications.waset.org/abstracts/search?q=Adlina%20Maisarah%20Mahadi"> Adlina Maisarah Mahadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Joo%20Kheng%20Goh"> Joo Kheng Goh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Bauhinia kockiana originates from Peninsular Malaysia, and it is grown as a garden ornamental plant. However, it is used as medicinal plant by Malaysia ‘Kelabit’ ethic group in treating various diseases and illnesses. This study focused on the assessment of the antibacterial activity of B. kockiana towards MRSA, to purify and identify the antibacterial compounds, and to determine the mechanism of antibacterial activity. Antibacterial activity of B. kockiana flower is evaluated qualitatively and quantitatively using disc diffusion assay and microbroth dilution method to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of extracts. Phytochemical analysis is performed to determine the classes of phytochemicals in the extracts. Bioactivity-guided isolation is performed to purify the antibacterial agents and identified the chemical structures via various spectroscopy methods. Scanning electron microscopy (SEM) technique is adopted to evaluate the antibacterial mechanism of extract and compounds isolated. B. kockiana flower is found to exhibit fairly strong antibacterial activity towards both strains of MRSA bacteria. Gallic acid and its ester derivatives are purified from ethyl acetate extract and the antibacterial activity is evaluated. SEM has revealed the mechanism of the extracts and compounds isolated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alkyl%20gallates" title="alkyl gallates">alkyl gallates</a>, <a href="https://publications.waset.org/abstracts/search?q=Bauhinia%20kockiana" title=" Bauhinia kockiana"> Bauhinia kockiana</a>, <a href="https://publications.waset.org/abstracts/search?q=MRSA" title=" MRSA"> MRSA</a>, <a href="https://publications.waset.org/abstracts/search?q=scanning%20electron%20microscopy" title=" scanning electron microscopy"> scanning electron microscopy</a> </p> <a href="https://publications.waset.org/abstracts/69391/anti-methicillin-resistant-staphylococcus-aureus-mrsa-compounds-from-bauhinia-kockiana-korth-and-their-mechanism-of-antibacterial-activity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/69391.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">369</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7253</span> Phytochemical and in vitro Antimicrobial Screening of Extract of Sunflower Chrysanthlum indicum</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I.%20Ibrahim">I. Ibrahim</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Mann"> A. Mann</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Phytochemical screening of crude Chrysanthlum Indicum revealed the presence of carbohydrates, flavonoids, saponins, tannins, alkanoids, steroidal nucleus and cardiac glycosides. The extract was evaluated against some pathogenic organisms by agar dilution method. The minimum inhibitory concentration and minimum bacteriocidal concentration (MBC) of the active extract of Chrysanthlum Indicum shows that its extract could be a potential source of antimicrobial agents. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=extract" title="extract">extract</a>, <a href="https://publications.waset.org/abstracts/search?q=phytochemicals" title=" phytochemicals"> phytochemicals</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial" title=" antimicrobial"> antimicrobial</a>, <a href="https://publications.waset.org/abstracts/search?q=antibacterial" title=" antibacterial"> antibacterial</a>, <a href="https://publications.waset.org/abstracts/search?q=Chrysanthlum%20indicum" title=" Chrysanthlum indicum "> Chrysanthlum indicum </a> </p> <a href="https://publications.waset.org/abstracts/15042/phytochemical-and-in-vitro-antimicrobial-screening-of-extract-of-sunflower-chrysanthlum-indicum" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15042.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">570</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7252</span> Synergistic Effect of Curcumin and Insulin on GLUT4 Translocation in C2C12 Cell</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Javad%20Mohiti-Ardekani">Javad Mohiti-Ardekani</a>, <a href="https://publications.waset.org/abstracts/search?q=Shabodin%20Asadii"> Shabodin Asadii</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Moradi"> Ali Moradi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Curcumin, the yellow pigment in turmeric, has been shown as an anti-diabetic agent for centuries but only in recent few years, its mechanism of action has been under investigation. Some studies showed that curcumin might exert its anti-diabetic effect via increasing glucose transporter isotype-4 (GLUT4) gene and glycoprotein contents in cells. To investigate this possibility, we investigate the effects of extract and commercial curcumin with and without insulin on GLUT4 translocation from intracellular compartments of nuclear or endoplasmic reticulum membranes (N/ER) into the cytoplasmic membrane (CM). Methods and Material: C2C12 myoblastic cell line were seeded in DMEM plus 20 % FBS and differentiated to myotubes using 2 % horse serum. After myotubes formation, 40 µmolar Extract and Commercial curcumin, with or without insulin as intervention, and as control 1 % DMSO were added for 3 h. Cells were washed and homogenized followed by ultracentrifuge fractionation, protein separation by SDS-PAGE and GLUT4 detection using semi-quantitative Western blotting. Data analysis was done by two independent samples t-test for comparison of mean ± SD of GLUT4 percent in categories. GLUT4 contents were higher in CM groups curcumin and curcumin with insulin in comparison to 1 % DMSO-treated myotubes control group. Results: As our results have shown extract and commercial curcumin induces GLUT4 translocation from intra-cell into cell surface. The results have also shown synergic effect of curcumin on translocation of GLUT4 from intra-cell into cell surface in the presence of 100 nm insulin. Discussion: We conclude that curcumin may be a choice of type-2 diabetes mellitus treatment because its extract and commercial enhances GLUT4 contents in CM where it facilitates glucose entrance into the cell. However, it is necessary to trace the signaling pathways which are activated by curcumin. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Curcumin" title="Curcumin">Curcumin</a>, <a href="https://publications.waset.org/abstracts/search?q=insulin" title=" insulin"> insulin</a>, <a href="https://publications.waset.org/abstracts/search?q=Diabetes%20type-2" title=" Diabetes type-2"> Diabetes type-2</a>, <a href="https://publications.waset.org/abstracts/search?q=GLUT4" title=" GLUT4"> GLUT4</a> </p> <a href="https://publications.waset.org/abstracts/41841/synergistic-effect-of-curcumin-and-insulin-on-glut4-translocation-in-c2c12-cell" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41841.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">243</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7251</span> Evolution Mechanism of the Formation of Rock Heap under Seismic Action and Analysis on Engineering Geological Structure </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jian-Xiu%20Wan">Jian-Xiu Wan</a>, <a href="https://publications.waset.org/abstracts/search?q=Yao%20Yin"> Yao Yin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In complex terrain and poor geological conditions areas, Railway, highway and other transportation constructions are still strongly developing. However, various geological disasters happened such as landslide, rock heap and so on. According to the results of geological investigation, the form of skirt (trapezoidal), semicircle and triangle rock heaps are mainly due to complex internal force and external force, in a certain extent, which is related to the terrain, the nature of the rock mass, the supply area and the surface shape of rock heap. Combined with the above factors, discrete element numerical simulation of rock mass is established under different terrain conditions based on 3DEC, and accelerated formation process of rock heap under seismic action is simulated. The fragmentation structure supply area is calculated, in which the most dangerous area is located. At the same time, the formation mechanism and development process are studied in different terrain conditions, and the structure of rock heap is judged by section, which can provide a strong theoretical and technical support for the prevention and control of geological disasters. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=3DEC" title="3DEC">3DEC</a>, <a href="https://publications.waset.org/abstracts/search?q=fragmentation%20structure" title=" fragmentation structure"> fragmentation structure</a>, <a href="https://publications.waset.org/abstracts/search?q=rock%20heap" title=" rock heap"> rock heap</a>, <a href="https://publications.waset.org/abstracts/search?q=slope" title=" slope"> slope</a>, <a href="https://publications.waset.org/abstracts/search?q=seismic%20action" title=" seismic action"> seismic action</a> </p> <a href="https://publications.waset.org/abstracts/40697/evolution-mechanism-of-the-formation-of-rock-heap-under-seismic-action-and-analysis-on-engineering-geological-structure" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40697.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">296</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=extract%20mechanism%20of%20action&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=extract%20mechanism%20of%20action&page=3">3</a></li> <li class="page-item"><a class="page-link" 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