CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "www.slas-discovery.org",cType: 'managed',cRay: '91346fd88ff9fcdf',cH: 'kDcW7I2ZbuFamxW5smGMuG5YJlqNrTMPdAhENmuzOK0-1739781251-1.2.1.1-xPi3ghFTP2VIUaxZ5KnBMqih2q57N5QNP4zbsQZJAdWtvymDS5GXR2EeIOT9bSAq',cUPMDTk: "\/article\/S2472-5552(24)00018-2\/fulltext?__cf_chl_tk=60EhTS.arCEGWz_DQzZ.dSVGHiE_kNxJChvxC07fuJU-1739781251-1.0.1.1-T_f_n7Vsg1pgXSupa8i4gER6xlLyzk0i627WANStm7c",cFPWv: 'b',cITimeS: '1739781251',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/article\/S2472-5552(24)00018-2\/fulltext?__cf_chl_f_tk=60EhTS.arCEGWz_DQzZ.dSVGHiE_kNxJChvxC07fuJU-1739781251-1.0.1.1-T_f_n7Vsg1pgXSupa8i4gER6xlLyzk0i627WANStm7c",md: "Ja_N.d9y8bdq5hJaum30K7GqWveApgWTlgRw3pD3aaY-1739781251-1.2.1.1-r8uqakHdBdrgRz_gZHHo.uPOwj0S77bX.gqgIbk4k3QsfOfIqh8AmGbIPiCbzAQl0RRoeYr59ariXJ4EUTjpEJYyC4XSjAe_EDI2kiV3.jZp_G.coANxl9kAlq3jXFltVSv3SHI2zL61fYX8fPVI6qcFiLyrMT8VZ0YzwN.hk0EXqM9dHHsV3B1zNNHUUqLpcBvXkzvEiCZ6X45lvqlv4OKR3FkzmoFORft6xiYb4KB_g1X9x48Fd_t9bGxQ27Aa9bu3hTfObcEyffZtccacAreSlu9mYAMXirJ.ACeoDxaefIQ_2hGOEFKWz.etdp06xF3W9mHxMoPzi9QdCxfBMKCTcuRErEQWXZS964PyNltLD31KdsUHnSabIeCY1L2POUyQQeIt.QEiUMLQghRpPAGpuW_4gnIzlKx6R.rjQBkp7ENh.mK5DUU9ipzMCJV1gx45v1NjP9e0BnMmQMuaojMtPVkQmkL_J_M8bhY..2Xodbr9hskfygTIBfVqGpf4nZQv_lYsanT_EAZT0FUB2zi.vGTebWYKp5ZPnmdllcwTVm.cIJgXE9vWa5dWqcL34DjSR6eIpfY4EfID0KmNyr_b8_r2dCmOAOWgdb2FE52XL7PxRWAOm9NfqrF7PsRHXU9ZsPKNJIbzAnV7vc216zbcQQcwk.Q.wAQCowmQtU0ZUcRVj7Lb500TFUUXgSNxmejdlorxWu5JgK4DHLKtUfM38Du4Rt4SDPdc8fM4CCppDfxVOOcMtBS81ZvlYZfwSGbMXFZOiYq3p7.UhISoQcjC3jVHw_KbNa3aOMWCEjPVYMnbPSlgSYtBlmocqZt2Nj9Zgaq81NXs39Nps2GhGIbs_vBNKJzPxqXr5SpG_I64B3izboNuMeFfHOoDnYJT36jNw6CUv7P8qHrcVZWsWKTPheP2ga5zu3bZ0cY4xAoFiPgKv.W6UPiJcD2KYi.M17q_mCuujN8bsvhRW66Ocr81lcJUu4agcXWBRXwu4eOipFPxqlQnwiARQKB6S5Gg7iiTgny2WD5CAurK7h7RXwl7xUM421fLNt94Emv2oirAuMn155oBWZUBu4BOkpBp_NKzKiFVT8R4hUQf1Y1hN17RlGMGF1l0a3DaaEcT6WrVDhMSXH3v6C0bnpp3X5RmJE3sZw_lNKeZtHE7aojVqaOhoS9RhbvaPfIt4LliZlZrSGFcApuhOChZbx1XokfPqw6gEQzBk055ygZQ8LHARb9mzP_OicLj6SiB0J1H679MKikk8JYctvZEjncVJvsTW_PH57NQ03KYW1BuUpyV1yKUA8VxOVSztZvaqD3WG8L8qsSTmbSoZMh69Y62SdYttRBFy4CJAaP9xRbO5.jnGCZ4_ezV9Z_yB3x1K9nBoVbPb8wj_ukIeGjeIzdUtLvDGY.OaMF5jcV.wPe_yNxh4Q4QbfOdVc.T_OjjBjJGjkxRGTVj5Hk.ydlJmjcYz4wpM6o4VTtmBIoMvoXMTkGnUwcgm1WQTbMklhW58YRv2QDeLW_vIG4VnrrPVNrnSUwZafhy9ScJCLTw0xXTPRarmv.wix7Bf8gj7AXW0Am4VMW1VujaCh2rddfWL5HvCy6kixHYZYgrTnVdOf_fOddCp36oyvNk3Mtup.3QZdgDu97Lluq6QxK7Eb_xh1gIXPWzst14exlThWGCQVu4shw5JPz.oKtY_TYRHPC96Gkid0sHtA.p4lzgiiv6mU6uuNowYEZUn404twjCiaCXS6b4ZB2p9OKqL6LLb5itfF.wMSdMcp2hxNNDa7TCQG5Sk9oBYT7lafBQIUTz68nq_T9DluFiFkY.syFxQp2YHWMLVnASU8O3Js0pIdUgVLoymIKynfzRjY8id6n6NyDNcmKLhmPbhU5cbkIXixy0tgP97ZbocNho3IWcsFzz6Xsw.SVlYeYYOesXorE.T2DqTjQbzJUwUjXriaMj96hQZCqd7zqtyFnxlw4XgIIbYNR5dE4yT0UAlolYyDXDO7LzhZxAv6qfkX9Fq3KSsq2j6hV5gXt2QyiYPoknwle5Qgtz9U4V9K0DukXkdXoeVlVHzrDAFv6jWnCLuXA.Yd19CG8nt_zBvfHlzYB6f6dO_TPukLxNKH_ZDatshMsnXf7YxI3tW4SmCmouY21wnXTlQKlGg3ruSPWYzUgVEXyc692qh1OFwfKNx7QGgilNL11xXTZrn_V.KWefIAGdPcpkgexZ.bJEeESC1NKgNJwP0H2kaiuGd.OdzJ1BDOA1fLiLlmiXlUvdGHMtAruLApIhylWbRBElveGtuR1TeD1LlkyJZwJtbd6ZhI65b.TfRzO6gW6Vy2XThxa6g.45wZZ2lcTjLwXK3qCajvOKdLktZCW1AZZB8pwO6hnNn5GhvDJO64ImBd5Os10jJqLmLI27I.ODzSibo6fpknrTQzFXhm27C06_1hdWYQi_uWdySvADkvqM894V5GtLuqhcQuTQ6KQKYZDwCYolVT3kfSmExQvnVxbJa.Iijgv2DiZT9H33PmM7wwVL1HPJ59U3SzX2bmRtV3NhKEnsSPemH4pkToMfRBeFFXJP0KKJjmjas1il7gs6YmWXxXcTiqTfSxfSERu2Dp3ExdjzdC2RsygbePs4.i_e",mdrd: "MFAnwSYQ4BEmTZYaN6KwX8N7lsQ5u3c71n_bVcYmNb0-1739781251-1.2.1.1-WXa.lhl6VZaBrLN6D9Do7yZCaQPDqXq_jiLNzhYVRPGWTyPsZupF3LfppSR5nK6qgYGtA9eRxHDF29CVGr0dapX4_ZsLlqBbv2Jm2UZDS57nq9jEPK6MC.BhzJJvI6okpQoQEnqOgvH54CVHITXWAZY1YUaUaG6ZvFL841GDtzRCfU6Bc66RQGg372Ui94OXhW7gIjME.jApnffEhfyvS_ImMinMUCc8li00Xt_C9dgeKstU9C2sR.DTsXjLvjpfsLewHGO1qBDOWNIHa9ephK6l.YTVNCrlnkVEgykU1CcNcUOMeRRdHMbKbZd9Pyp6z2syHe0R_aV08uWf.hTQmuhJLkkKU4eHpkKnykg1_ktOZ1yJMfei10xqIDmYEnhiZRi_MH8htvAbkNOqEU_6AueVmevX5YEINVfRQV82vCOdfObjjz1t8.Hz4EfHRvuR4Sao.561EUArDbSGu.4Yvap_VTxMiGG1YtpzJKTr1Evf6iLbaoero_DukM7lgvbkeQuAkXBIkgIKyc.i6NjA2wZlwVUxjO7UVouJhzs4fgHbLgLQzcO2D63gVkia2EwK5QV2VVCFocnN8ThxvhKr0yotmtaG1dPyRbH_fO8nYWA_563BvOMcbEIoS_xwvSX13HjzLM8ObT4YhxHO6Qlz8ioPZciQKAaAy9kCFFN45cdMlqCWcZLBOC.nwl_dLLe2YGY7JyrmY1kKbrOFdvJ3yujOV5HbZrmn63p51VzeZMhb0cg8x4h75SZ6ywfeh.Fukdzi857Ijmc7_7RRKwcM1pk6pqwDBoDpZZJotQfINwl1XHJ7HJ8gItDtfZIoe.vTjZYyYMxAnkdOcgwpgT8xOA.HXJ4d0UgtZS2Vk8qLVa_5pTTQUTT0niGTtjVcKiRTWPPziokKJj5I7tQVnkvi9jIxIOJYIZuM1YsspqNGycWMW7lE19MkuyCT_sxFSJbFKQQV6waSdDQkzOl_B8h6HEluLGIIJuK_00JWs.U.HYKuyLTVglHbVBfn7gGOK6t4aOMHuCObkqA_beqdBuqw_.IRqcIWC4sty.wmsazcsZITPVo67U2I9FseU7Qw9J9J.EdGtqKhm.0kxGGNYP59MW.dfN1fVuovUmZucEVLAO8otXDNYnjM_B4gwU9kdv8nmfga2nK8U2H9GzqR7qoDfxcRj5ORhzwvenilySt8L1LjCKosy4mC49cPBJZSYKOFLQwCE5Cm.QAlutEgqiTIaxR9Lnfrn4j7LFph._amVeOgLuM__eTbqvQ3v3t2mTeBhKHUEW4TXl5LTkGuiY72_f_kNP9Rq4.ELWAy5UCw5.QCiFAnxkCLTTUFP2JfGffEiVgLqYVz7LIxS9K0TEr11cto4h50KQPM59J6lpqOfA4kuL8JtErekiO8q.1LCWYBKwbZfEiviqh8Aam5qo.ZNxFJBI_nnIaGdYMTLHlTAu2LkEvTNta8TF60_nFQthagfAyju0OMdQFMMnN1vKEASLar4sdLgXbmJLWQEjixe.fD4jZvapg9x500ZdObCkxNl_MtsYD3mHNAssCW8th7bzH0LBrRjDxSKmPrrFbd3BbhMhP1YCG_XJmB_wYfekEh2vAP32S10CQk9wuqr3HxB2VXvceTbkfCPxMrqOB8E8rnLz9X6_HAaBFLTgT0ZmFsaatTEapwYh_9MLCLHzy66KK895yQsvgDL3XmRpG1H8UAv80APK1bEhIoO8TmSt_CJyxomVuVjA3ohqWNzxqhPsyeFlC0hVFW3jWp.fkL0dUzS9LmcFlWrRd2_AXQelrN40TMyC1EH7yxoHnc5_Kh.kcRq4tr.onyXcA0DSR_RAXjaViNlia3M399GrfKvmkJOOQW4OOy7zydOjYINzvw_7q70BT7JT81X7iJddVFzRPzLNDQTROgDwf932_z6Gl4qQxDJdh8kqN8YFeNhw2j2mhP.J.KUFnnj97gU6neNaw8IFPIfI1BwtLcnMKRNZ5vwxVyp.TqwOXD0n.FITe9VQ"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=91346fd88ff9fcdf';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/article\/S2472-5552(24)00018-2\/fulltext?__cf_chl_rt_tk=60EhTS.arCEGWz_DQzZ.dSVGHiE_kNxJChvxC07fuJU-1739781251-1.0.1.1-T_f_n7Vsg1pgXSupa8i4gER6xlLyzk0i627WANStm7c" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>