CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="120"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "publications.waset.org",cType: 'non-interactive',cRay: '9133a188e908fdc1',cH: 'qVq0tbmwVHr01M30iZZ34bfs5TlchNdrz6Ewb3uoRX0-1739772801-1.2.1.1-ltULRza.2MtZzrjU01f2JBgsFQweiIKDly4pXN2LjME9iSQZ4zaOk973Yc_.XJB3',cUPMDTk: "\/abstracts\/search?q=IC50&__cf_chl_tk=bqm0E4nvR_.ROMx8NIP815eoGrh.3Yv4JLzKuRI.7Po-1739772801-1.0.1.1-uijoeQaFbiQ4dRA67cqmtLNciALDQnZrwTRZBHsEM6M",cFPWv: 'b',cITimeS: '1739772801',cTTimeMs: '1000',cMTimeMs: '120000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/abstracts\/search?q=IC50&__cf_chl_f_tk=bqm0E4nvR_.ROMx8NIP815eoGrh.3Yv4JLzKuRI.7Po-1739772801-1.0.1.1-uijoeQaFbiQ4dRA67cqmtLNciALDQnZrwTRZBHsEM6M",md: "KMj5ojP43NBbNjsXLAjEYlf6tTp76csrNnzZaGaRyvw-1739772801-1.2.1.1-cXUDGC8BewbWVjh1gGc2jAJ0vFrzzLZvWkbqMZHb0..32vNw2UAer8nAkNvL69i3WnwOY1lMGbriRsMPxtjivSZnF4uD.yLbcdJCHkCGrhtSRaDS_.91YzWJ3YpEvn2FYvqjWa0KfqCX02F5ZC4vtON7A0m6yGcconN.UEbM4OTEJELZCWRrh8FFjLgmmKp8dbli6WmKvlSf.m13_7SFYamHHfGSH0yUQUfi1w32tiaQalBmF3RFtadX2szz15gUKjv.A82RjT.SUbeDJ.deoORbhDU.VvVYvG0oRJFqkU951XwMF72.ieLDOA4CxVlPXnEyP95GZz70_FQu49hNOJdTpMFYs3qfC15rHT3HkEYnPDUjh9EI1L3GJZLOTsHUFohr319xMIFze5EqbAOBpV5LP708v6l2jsAUrpu4f5zAK6fe_4kWHg1esPnHA.GPmxeD3r4yGv4rQerSHaHpRHhhZb8ymckeDRZtu9H906fXxUO61jI58qTgfL2yWrMFbB9aYaD7ix4id8liSii9gjUBwdB.A9L.oxvixbAjuZj10Jd6TTjpQnXE3RltowlFIKtgtVVsAm_iMXLgtX5.2YXmjWroTCUNk7HV_YX_yniP7S5GrGVIcf94mD1zNP1a5HtCoXRVaHw0pMq7jhQKBAIxglDqxEi8TU5HxWLv9qqPub0f4ATXP4CmEmxIB_PO6lMEBTYaZ7AzC23NTwgzoYqL9iIOFcRo3zGwgmBsI7_Dgqy.fzsIdLtvb2esVFW8bU74avDWELeiOxn1pcfT_FW9m8xeDuS7UVfjcmBqR2WbgWoKaJ6zIT2t.IPqxZ99DzN7Yn9OP8_MkcNvCbs6rdjaoW0YbmH5F40Ocj6mtHtaduT7RdQbgH213gKkGBt8j7CR65QibBqhS03r5QYntggOMTjVJ3Z1bnaX7XIX.VkvBrud4S5LivVjyLfKGMyhH2mwC9e1tM7sucV350jHKQqhy3aemJwwf00xaz3G0dCjRODBsERu4jWu2QGkFxlNZi8.baJbaD6aSEu_xgpKQRSak5z3pDkrqb1CUz2jGW.ZpMcjLRLUsaNG0SxNCRLHYTnBXoRSB9Lc9aH09.FEqAOnuvbGCmXPvvkX42cZzCD8YIgiwEO0oipWVHgGTDDu79.AGvieM5a9tPH3NhQH4qQQIYzNdBRRb_SDs_7DOOEXs9K6sHPoGFtThQoWRr2Munaz5GhY4oqJY6nOmd.uXfVJJX19G2hpIbnzeWrJ4QdT3QRLxJIKpTHoY7vdEhfFG4E4BSFO9dYSHgVjyAL4zKM4RdCHOUeCqrggDWZD8lfVm6oiNOuII8E3zm34i6IGEnf9dl0AhE9QO8bJ_8RtsftJ73YQfRJ326vf7rhkl7fnbc8nn8x4ceZTvFaGm1BMIjrWDAZTiBmmdphOHHtdKgP4L27gws7IsH11lIb3_txUTAPYFi35bOHivN6BCjdKiGyxERBd8AIFCu9v5B_4e7MMDDg7rRJRQPtHhGgDr7ysO.EK39sNWvr.fGtX5CkZFoqU9mdxcc7QiuZpJV06IKUAOEdkGjSftmSR9a5FXt3dB03gABeAM0aGN7j5PBUTzXJIw.GUqU7SM5.Zn6s6IIg7kvMJmeqZvZxN9p_NOKW91o3v8iXz8WpnFj_.GyNahVdjTG1tLvumLBFscpVBlSsx0nVVbxB5yGqBgDsw25tBNj2m4daSG_kjZV9R.1XVFPkda4oAuyfv7FST75N2VX5LbDlO8IelOy1ZgCUd9fjJDp7HikmcqN_TGdRKc_QcGCPPP6Z1FRGLtnjF5L6_1lOLfwdZsPkgkrPWbdQQcu8Q7pQByrslVmG9XhGIyCe88haOhf_5xLl1eaasfVcT3a3DU9YuxKvnvcV2xC8Jh6ti7QB4c7XH1zAUB_vABq.k",mdrd: "XFk_hjzVg7Uoym0ER3uxj2KG5EpzCm.ND.06B6oe0TU-1739772801-1.2.1.1-vx0FiMEB1hZsc.ko8O95muWPkLhJk9bXGJmDc72a8G1PQEfkFNMiqFBHQ8vExzRv35wd9CgRUVu8_Vusv3_Uioo8cHlsJO3BfsV9FIc5e2U8OvlgLpJkQJ_o1OFZPkqroT7kxMLLhPDr_DLnUUZQyPkAby5Ot57a1Ea5sHsW8fYbt5iiLO3FEmFxv_PoUGn5ndW5REILU45WaR9eaOR0PpynNDTOIvbb_w0Z9YLz0T5_ha0KFvFOxPAkrxRkt5fAeGGvyHlGFD5lKHtKlpHWUv56YBCEHx.EfC_oV3R_MhRlHzykDknKMj7zmOiJ1.Vu8hv0i.K60xbjZDH4buzipEDjgyE_TXhKOIWk94G_qvrDRiRZ0EnQ9.WSH1KWLwCRx2BfKKAEK.v2kpkpdcuhfUJIX5ekVmxPR6Uwdnhmi_8xOntrWxJhI7guMzcacL19UoSiusv_fiE2Br8n2r5vaPDhyX5BgWPInsXZFwUTpikey2w3pk6jj43tHXnxJ9toFhKB5EfdZwOS010iauGUiv8ZLXB7t8y2P5fe5jUZ.NyDCeY4WrYZh0i7m0KahB2LKvreV3gjnScxJhXlW9tVzAXSgwBCG0LAil6.8smZ2rDs0imoRA4Z_VzAaiqTADLIhoOo7dO73zMwWVg2I4jxIDHsNmOfIJQUlGO2geQNiqhE1nkgbW34z5_HQwO844rIh9OsKz6LED21lf0IW9taDT2me21Ja2mOBoX2SF.JYusWBAxPvXOlvo2nVS7J8T8cbjdMlJguPDve7hXnl56zX9T5FHaykLsLoRzNutfBcAFI17KbSRRTruMNZJdeGD6XXuSFchCzOsyc7Jx5FeF8nhj7hpyDMog_ION23vkm.0aErK1goOmWnmqZMQ0zk.jiF.uYCc8TkNv2.kpceREuQbao8gJVf7g37fuH.h0tX416tn6FSweHpky54scWxHsmoPRQ2Ua7bxC3V0QFkk.NraIowa2rGtLu0N79rDLllwDs6XJuqvTTBrK9yf0CcTwevGtTAwX1PLID5hyKR7BNBT4wBOw3wVfrYDve0yww8QMx_wNgTWDnXxeGfgKjBd_i5nUJySrzQyd2HJMwgWa.ImoUsKynfgvLbkGz8yAGTCSgHktStXh09_w8_St1XMyOf6UOnHW5WEnUA64dgCEpwtIDaJWoxEnYhlpQPDNaOyENZBLu7pV9xj9omySIH4jADl4iu42SUWhE5MYzCioKW3MflnXuiDEOYKoIBPdNuhkOlMLlGQ8kI5utpiZRV368uScdipQmHs24F7PeL5ZABjkiMBKzIPrTIJBDGNfz1ApSSGODjQIAON3HjLsGB.tq0MwNVUdL2E.x4YS3R4OsXG.v.QgZrzWoCFp7WiHb83ZNPSEwWFy60xaabZtvDhN3l_qCEdiH7Rr0kxDWSJX7Y1fEVXBSieHnS0NXJZz4AvIRrFhYdByDWjmIi2VBhiUb8LKGaPVXENLojPC0.N0Fgiz4eGSGLvbWCb7buyUKty9uWrBKn.oO0PXpb8fH1gilWtY4bs2ONTdCYSieMLBtHnd3_FG6qYSq7VSUkkSuGHhryC0DyWVNpMPqHPDuKLeo1URXHdC19z0w5vLUBp0z2O3gm9EV.PLxVzkvxCOK4ZW_G.UHwqgN5yUxEl6218KupoVr9Vnsb2WD3u57cE5woM.ZOp7DjmIrrbg8OlcevJmgEMoo0Z9WeMOIpXe9h6oeAyarB7hm6Z7ildLLYl7s4kgy9T4V5Htm6m1mEZeuvi1vaHW.HZUtOE2j04Y7o7HxiLlvg3tzoyXx3j6YO1Zyh2JAQfV7dD6t8D1nE725hUwa1l0NQRkom97okIni5_bk.FiJtBBvAcuiFAINYNmoOnvq_yDsgcQpFTBEUMkmZlPHEqzgM_H.K.uJIcsLGD1Q9mkVKuzFIkJPtckjXRKf_Dky5zlsI9wYaGKz35FiAvIr4QzQim8ISGBDPCOMz0rUeY5.GErF3aRV7NWV5M2miA"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=9133a188e908fdc1';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/abstracts\/search?q=IC50&__cf_chl_rt_tk=bqm0E4nvR_.ROMx8NIP815eoGrh.3Yv4JLzKuRI.7Po-1739772801-1.0.1.1-uijoeQaFbiQ4dRA67cqmtLNciALDQnZrwTRZBHsEM6M" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>