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Mac:</b><br> Mit diesen Tastenkombinationen k枚nnen Sie die Schriftgr枚脽e anpassen:<br></p><ul class="list-normal"><li>[Cmd] - [+]: Schrift vergr枚脽ern</li><li>[Cmd] - [-]: Schrift verkleinern</li><li>[Cmd] - [0]: Schriftgr枚脽e zur眉cksetzen</li></ul></div><et-popover-arrow></et-popover-arrow></dialog></et-popover-content></et-popover-root></li></ul></nav></div></div></div></div><div class="menu-main-container bg-blue-darkest"><div class="main-navigation-button-container frame-container frame-container-default d-md-none"><button class="btn main-navigation-button p-4" type="button" data-bs-toggle="offcanvas" data-bs-target="#main-navigation" aria-controls="main-navigation" aria-label="Men眉枚ffnen" ><span class="burger-icon"></span></button></div><nav id="main-navigation" tabindex="-1" class="navbar navbar-main frame-container frame-container-default offcanvas offcanvas-start" ><button type="button" class="btn-close btn-close-white text-reset navbar-main-mobile-close" 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id="frame-backgroundimage-8201" class="frame-backgroundimage"></div></div></div></div><div class="frame-type-intro"><div class="frame-container frame-container-default"><div class="frame-inner"><header class="frame-header"><h1 class="element-header mb-2"><span>Identifikation und Pathogenese heredit盲rer Nephropathien</span></h1></header></div></div></div></div><nav class="breadcrumb-section" aria-label="Brotkr眉melnavigation"><div class="container"><p class="sr-only" id="breadcrumb">Sie sind hier:</p><ol class="breadcrumb"><li class="breadcrumb-item"><a class="breadcrumb-link" href="https://www.uk-erlangen.de/" title="Zur Startseite des Universit盲tsklinikums Erlangen"><svg height="37" xmlns="http://www.w3.org/2000/svg" viewBox="0,0,63,64"><g><path d="M20.937+21.0438L0+21.0438L0+42.3789L20.937+42.3789L20.937+21.0438Z" opacity="1" fill="#00a579"/><path d="M62.813+21.0438L41.876+21.0438L41.876+42.3789L62.813+42.3789L62.813+21.0438Z" opacity="1" fill="#00a579"/><path 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class="breadcrumb-text">Identifikation und Pathogenese heredit盲rer Nephropathien</span></li></ol></div></nav><main id="page-content" class="bp-page-content main-section"><div class="section section-before-content"></div><div class="section section-default"><div id="c45959" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><p>The rate of chronic kidney disease (CKD) is continuously increasing worldwide. In general CKD causes high morbidity and mortality, therefore this disease has a very high socioeconomic impact. Importantly, more than 25% of patients with end stage renal disease (ESRD) have at least one first or second degree relative also suffering fromESRD. This figure illustrates the important role of genetics in CKD. Many of these patients and their nephrologists do not know the correct diagnosis. Furthermore, we expect that many genes of hereditary nephropathies have not yet been identified. </p><p>Our group is interested in such diseases and aims for a careful clinical characterization. We attempt to clarify the underlying cause of nephropathy in incident patients, as well as the pathogenesis of novel disease genes. For this purpose, we have a close clinical and scientific cooperation with the Institute for Human Genetics in Erlangen (Director Prof. Dr. Andr茅 Reis). Our scientific spectrum and methodology stretches from molecular genetics to molecular biology and attempts to transfer these findings from cell culture to model organisms such as mouse and zebra fish. Examples of our recent research objectives are autosomal dominant tubulointerstitial kidney diseases, autosomal recessive (novel) ciliopathies and hereditary complement-associated glomerulopathies (C3G).</p></div></div></div></div></div><div id="c65403" class=" frame frame-default frame-type-image frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h3 class="element-header "><span>Team AG Wiesener</span></h3></div><div class="gallery-row"><div class="gallery-item gallery-item-size-2"><div class="image-wrap image-wrap-lightbox"><figure class="image"><div class="position-relative"><a href="https://www.medizin4.uk-erlangen.de/fileadmin/_processed_/e/d/csm_AG_Wiesener_2022_V2_38904d3f0e.jpg" data-pswp-width="1200" data-pswp-height="861" target="_blank" class="lightbox" title="" ><picture class=""><source data-variant="default" data-width="781" data-height="585" media="(min-width: 1600px)" srcset="/fileadmin/_processed_/e/d/csm_AG_Wiesener_2022_V2_b8b2f63d1c.jpg 1x"><source data-variant="xlarge" data-width="611" data-height="458" media="(min-width: 1400px)" srcset="/fileadmin/_processed_/e/d/csm_AG_Wiesener_2022_V2_32eada0e90.jpg 1x"><source data-variant="large" data-width="611" data-height="458" media="(min-width: 1260px)" srcset="/fileadmin/_processed_/e/d/csm_AG_Wiesener_2022_V2_32eada0e90.jpg 1x"><source data-variant="medium" data-width="493" data-height="369" media="(min-width: 1024px)" srcset="/fileadmin/_processed_/e/d/csm_AG_Wiesener_2022_V2_30a0d0e3dd.jpg 1x"><source data-variant="small" data-width="341" data-height="255" media="(min-width: 720px)" srcset="/fileadmin/_processed_/e/d/csm_AG_Wiesener_2022_V2_0fd72d8835.jpg 1x"><source data-variant="extrasmall" data-width="682" data-height="511" srcset="/fileadmin/_processed_/e/d/csm_AG_Wiesener_2022_V2_325c7f0b7e.jpg 1x"><img class="img-fluid" loading="lazy" src="/fileadmin/_processed_/e/d/csm_AG_Wiesener_2022_V2_6bb6a651fa.jpg" width="781" height="585" title="" alt=""></picture></a></div></figure></div></div></div></div></div></div></div></div><div id="c65187" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h3 class="element-header "><span>Kooperationen</span></h3></div><ul class="list-normal"><li>SFB 1350, <a href="https://www.uni-regensburg.de/biologie-vorklinische-medizin/sfb1350/project-area-c/index.html" target="_blank" class="link link-external" title="EXT:site/Resources/Private/Language/locallang_rte.xml:external_link_titleText_new_window" rel="noreferrer">Universit盲t Regensburg</a></li></ul></div></div></div></div></div><div id="c42950" class=" frame frame-default frame-type-list frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h3 class="element-header "><span>Arbeitsgruppenleiter</span></h3></div><div class="result-list-items contact-items result-list-items-glossar columnsCount2"><div class="result-list-item result-list-item-image"><div class="list-item-image"><div class="image-wrap contact-image ratio ratio-1x1"><a title="脰ffnet die Visitenkarte von Prof. Dr. med. 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