CINXE.COM

Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations - Penn Genetics

<!DOCTYPE html> <html xmlns="http://www.w3.org/1999/xhtml" lang="en-US"> <head> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /> <meta name="viewport" content="width=device-width, initial-scale=1, user-scalable=yes"> <!--[if lt IE 9]> <script src="http://cdnjs.cloudflare.com/ajax/libs/html5shiv/3.7/html5shiv.js"></script> <script src="http://cdnjs.cloudflare.com/ajax/libs/selectivizr/1.0.2/selectivizr-min.js"></script> <![endif]--> <link rel="pingback" href="https://genetics.med.upenn.edu/xmlrpc.php" /> <meta name='robots' content='index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1' /> <!-- This site is optimized with the Yoast SEO plugin v23.9 - https://yoast.com/wordpress/plugins/seo/ --> <title>Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations - Penn Genetics</title> <link rel="canonical" href="https://genetics.med.upenn.edu/integrative-analysis-reveals-rna-g-quadruplexes-in-utrs-are-selectively-constrained-and-enriched-for-functional-associations/" /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="article" /> <meta property="og:title" content="Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations - Penn Genetics" /> <meta property="og:description" content="Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations. David S. M. Lee,聽Louis R. Ghanem聽&amp;聽Yoseph Barash" /> <meta property="og:url" content="https://genetics.med.upenn.edu/integrative-analysis-reveals-rna-g-quadruplexes-in-utrs-are-selectively-constrained-and-enriched-for-functional-associations/" /> <meta property="og:site_name" content="Penn Genetics" /> <meta property="article:published_time" content="2020-01-27T15:40:59+00:00" /> <meta property="article:modified_time" content="2020-06-11T17:42:41+00:00" /> <meta name="author" content="Kimberly Runyan" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:label1" content="Written by" /> <meta name="twitter:data1" content="Kimberly Runyan" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"WebPage","@id":"https://genetics.med.upenn.edu/integrative-analysis-reveals-rna-g-quadruplexes-in-utrs-are-selectively-constrained-and-enriched-for-functional-associations/","url":"https://genetics.med.upenn.edu/integrative-analysis-reveals-rna-g-quadruplexes-in-utrs-are-selectively-constrained-and-enriched-for-functional-associations/","name":"Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations - Penn Genetics","isPartOf":{"@id":"https://genetics.med.upenn.edu/#website"},"datePublished":"2020-01-27T15:40:59+00:00","dateModified":"2020-06-11T17:42:41+00:00","author":{"@id":"https://genetics.med.upenn.edu/#/schema/person/b1d553e62aea0e27398c8cca652238c4"},"breadcrumb":{"@id":"https://genetics.med.upenn.edu/integrative-analysis-reveals-rna-g-quadruplexes-in-utrs-are-selectively-constrained-and-enriched-for-functional-associations/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https://genetics.med.upenn.edu/integrative-analysis-reveals-rna-g-quadruplexes-in-utrs-are-selectively-constrained-and-enriched-for-functional-associations/"]}]},{"@type":"BreadcrumbList","@id":"https://genetics.med.upenn.edu/integrative-analysis-reveals-rna-g-quadruplexes-in-utrs-are-selectively-constrained-and-enriched-for-functional-associations/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://genetics.med.upenn.edu/"},{"@type":"ListItem","position":2,"name":"Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations"}]},{"@type":"WebSite","@id":"https://genetics.med.upenn.edu/#website","url":"https://genetics.med.upenn.edu/","name":"Penn Genetics","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://genetics.med.upenn.edu/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https://genetics.med.upenn.edu/#/schema/person/b1d553e62aea0e27398c8cca652238c4","name":"Kimberly Runyan","sameAs":["https://genetics.med.upenn.edu"],"url":"https://genetics.med.upenn.edu/author/kimberlygenetics/"}]}</script> <!-- / Yoast SEO plugin. --> <link rel="alternate" type="application/rss+xml" title="Penn Genetics &raquo; Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations Comments Feed" href="https://genetics.med.upenn.edu/integrative-analysis-reveals-rna-g-quadruplexes-in-utrs-are-selectively-constrained-and-enriched-for-functional-associations/feed/" /> <script type="text/javascript"> /* <![CDATA[ */ window._wpemojiSettings = {"baseUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/72x72\/","ext":".png","svgUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/svg\/","svgExt":".svg","source":{"concatemoji":"https:\/\/genetics.med.upenn.edu\/wp-includes\/js\/wp-emoji-release.min.js?ver=6.6.2"}}; /*! This file is auto-generated */ !function(i,n){var o,s,e;function c(e){try{var t={supportTests:e,timestamp:(new Date).valueOf()};sessionStorage.setItem(o,JSON.stringify(t))}catch(e){}}function p(e,t,n){e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(t,0,0);var t=new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data),r=(e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(n,0,0),new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data));return t.every(function(e,t){return e===r[t]})}function u(e,t,n){switch(t){case"flag":return n(e,"\ud83c\udff3\ufe0f\u200d\u26a7\ufe0f","\ud83c\udff3\ufe0f\u200b\u26a7\ufe0f")?!1:!n(e,"\ud83c\uddfa\ud83c\uddf3","\ud83c\uddfa\u200b\ud83c\uddf3")&&!n(e,"\ud83c\udff4\udb40\udc67\udb40\udc62\udb40\udc65\udb40\udc6e\udb40\udc67\udb40\udc7f","\ud83c\udff4\u200b\udb40\udc67\u200b\udb40\udc62\u200b\udb40\udc65\u200b\udb40\udc6e\u200b\udb40\udc67\u200b\udb40\udc7f");case"emoji":return!n(e,"\ud83d\udc26\u200d\u2b1b","\ud83d\udc26\u200b\u2b1b")}return!1}function f(e,t,n){var r="undefined"!=typeof WorkerGlobalScope&&self instanceof WorkerGlobalScope?new OffscreenCanvas(300,150):i.createElement("canvas"),a=r.getContext("2d",{willReadFrequently:!0}),o=(a.textBaseline="top",a.font="600 32px Arial",{});return e.forEach(function(e){o[e]=t(a,e,n)}),o}function t(e){var t=i.createElement("script");t.src=e,t.defer=!0,i.head.appendChild(t)}"undefined"!=typeof Promise&&(o="wpEmojiSettingsSupports",s=["flag","emoji"],n.supports={everything:!0,everythingExceptFlag:!0},e=new Promise(function(e){i.addEventListener("DOMContentLoaded",e,{once:!0})}),new Promise(function(t){var n=function(){try{var e=JSON.parse(sessionStorage.getItem(o));if("object"==typeof e&&"number"==typeof e.timestamp&&(new Date).valueOf()<e.timestamp+604800&&"object"==typeof e.supportTests)return e.supportTests}catch(e){}return null}();if(!n){if("undefined"!=typeof Worker&&"undefined"!=typeof OffscreenCanvas&&"undefined"!=typeof URL&&URL.createObjectURL&&"undefined"!=typeof Blob)try{var e="postMessage("+f.toString()+"("+[JSON.stringify(s),u.toString(),p.toString()].join(",")+"));",r=new Blob([e],{type:"text/javascript"}),a=new Worker(URL.createObjectURL(r),{name:"wpTestEmojiSupports"});return void(a.onmessage=function(e){c(n=e.data),a.terminate(),t(n)})}catch(e){}c(n=f(s,u,p))}t(n)}).then(function(e){for(var t in e)n.supports[t]=e[t],n.supports.everything=n.supports.everything&&n.supports[t],"flag"!==t&&(n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&n.supports[t]);n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&!n.supports.flag,n.DOMReady=!1,n.readyCallback=function(){n.DOMReady=!0}}).then(function(){return e}).then(function(){var e;n.supports.everything||(n.readyCallback(),(e=n.source||{}).concatemoji?t(e.concatemoji):e.wpemoji&&e.twemoji&&(t(e.twemoji),t(e.wpemoji)))}))}((window,document),window._wpemojiSettings); /* ]]> */ </script> <style type="text/css"> #wpadminbar #wp-admin-bar-my-networks > .ab-item:first-child:before { content: "\f325"; top: 3px; } </style> <style id='wp-emoji-styles-inline-css' type='text/css'> img.wp-smiley, img.emoji { display: inline !important; border: none !important; box-shadow: none !important; height: 1em !important; width: 1em !important; margin: 0 0.07em !important; vertical-align: -0.1em !important; background: none !important; padding: 0 !important; } </style> <link rel='stylesheet' id='wp-block-library-css' href='https://genetics.med.upenn.edu/wp-includes/css/dist/block-library/style.min.css?ver=6.6.2' type='text/css' media='all' /> <style id='classic-theme-styles-inline-css' type='text/css'> /*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} </style> <style id='global-styles-inline-css' type='text/css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--color--black: #000000;--wp--preset--color--cyan-bluish-gray: #abb8c3;--wp--preset--color--white: #ffffff;--wp--preset--color--pale-pink: #f78da7;--wp--preset--color--vivid-red: #cf2e2e;--wp--preset--color--luminous-vivid-orange: #ff6900;--wp--preset--color--luminous-vivid-amber: #fcb900;--wp--preset--color--light-green-cyan: #7bdcb5;--wp--preset--color--vivid-green-cyan: #00d084;--wp--preset--color--pale-cyan-blue: #8ed1fc;--wp--preset--color--vivid-cyan-blue: #0693e3;--wp--preset--color--vivid-purple: #9b51e0;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: 20px;--wp--preset--font-size--large: 36px;--wp--preset--font-size--x-large: 42px;--wp--preset--spacing--20: 0.44rem;--wp--preset--spacing--30: 0.67rem;--wp--preset--spacing--40: 1rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2.25rem;--wp--preset--spacing--70: 3.38rem;--wp--preset--spacing--80: 5.06rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);}:where(.is-layout-flex){gap: 0.5em;}:where(.is-layout-grid){gap: 0.5em;}body .is-layout-flex{display: flex;}.is-layout-flex{flex-wrap: wrap;align-items: center;}.is-layout-flex > :is(*, div){margin: 0;}body .is-layout-grid{display: grid;}.is-layout-grid > :is(*, div){margin: 0;}:where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;}:where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;}.has-black-color{color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-color{color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-color{color: var(--wp--preset--color--white) !important;}.has-pale-pink-color{color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-color{color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-color{color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-color{color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-color{color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-color{color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-color{color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-color{color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-color{color: var(--wp--preset--color--vivid-purple) !important;}.has-black-background-color{background-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-background-color{background-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-background-color{background-color: var(--wp--preset--color--white) !important;}.has-pale-pink-background-color{background-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-background-color{background-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-background-color{background-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-background-color{background-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-background-color{background-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-background-color{background-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-background-color{background-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-background-color{background-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-background-color{background-color: var(--wp--preset--color--vivid-purple) !important;}.has-black-border-color{border-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-border-color{border-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-border-color{border-color: var(--wp--preset--color--white) !important;}.has-pale-pink-border-color{border-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-border-color{border-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-border-color{border-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-border-color{border-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-border-color{border-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-border-color{border-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-border-color{border-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-border-color{border-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-border-color{border-color: var(--wp--preset--color--vivid-purple) !important;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;} :where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;} :where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;} :root :where(.wp-block-pullquote){font-size: 1.5em;line-height: 1.6;} </style> <link rel='stylesheet' id='ctf_styles-css' href='https://genetics.med.upenn.edu/wp-content/plugins/custom-twitter-feeds/css/ctf-styles.min.css?ver=2.2.5' type='text/css' media='all' /> <link rel='stylesheet' id='upcoming_events-css' href='https://genetics.med.upenn.edu/wp-content/plugins/livewhale_events_integration//css/style.css?ver=1.0.0' type='text/css' media='all' /> <link rel='stylesheet' id='style-css' href='https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/style.css?ver=6.6.2' type='text/css' media='all' /> <link rel='stylesheet' id='fontawesome-css' href='https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/assets/css/font-awesome.min.css?ver=6.6.2' type='text/css' media='all' /> <link rel='stylesheet' id='lightbox-css' href='https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/css/lightbox.css?ver=6.6.2' type='text/css' media='all' /> <link rel='stylesheet' id='bxslidercss-css' href='https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/css/jquery.bxslider.css?ver=6.6.2' type='text/css' media='all' /> <link rel='stylesheet' id='animations-css' href='https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/css/animations.css?ver=6.6.2' type='text/css' media='all' /> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-includes/js/jquery/jquery.min.js?ver=3.7.1" id="jquery-core-js"></script> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-includes/js/jquery/jquery-migrate.min.js?ver=3.4.1" id="jquery-migrate-js"></script> <link rel="https://api.w.org/" href="https://genetics.med.upenn.edu/wp-json/" /><link rel="alternate" title="JSON" type="application/json" href="https://genetics.med.upenn.edu/wp-json/wp/v2/posts/1444" /><link rel='shortlink' href='https://genetics.med.upenn.edu/?p=1444' /> <link rel="alternate" title="oEmbed (JSON)" type="application/json+oembed" href="https://genetics.med.upenn.edu/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fgenetics.med.upenn.edu%2Fintegrative-analysis-reveals-rna-g-quadruplexes-in-utrs-are-selectively-constrained-and-enriched-for-functional-associations%2F" /> <link rel="alternate" title="oEmbed (XML)" type="text/xml+oembed" href="https://genetics.med.upenn.edu/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fgenetics.med.upenn.edu%2Fintegrative-analysis-reveals-rna-g-quadruplexes-in-utrs-are-selectively-constrained-and-enriched-for-functional-associations%2F&#038;format=xml" /> <link rel="icon" href="https://genetics.med.upenn.edu/wp-content/blogs.dir/66/files/sites/66/2020/02/cropped-favicon-1-32x32.png" sizes="32x32" /> <link rel="icon" href="https://genetics.med.upenn.edu/wp-content/blogs.dir/66/files/sites/66/2020/02/cropped-favicon-1-192x192.png" sizes="192x192" /> <link rel="apple-touch-icon" href="https://genetics.med.upenn.edu/wp-content/blogs.dir/66/files/sites/66/2020/02/cropped-favicon-1-180x180.png" /> <meta name="msapplication-TileImage" content="https://genetics.med.upenn.edu/wp-content/blogs.dir/66/files/sites/66/2020/02/cropped-favicon-1-270x270.png" /> </head> <body class="post-template-default single single-post postid-1444 single-format-standard"> <!--Mobile Menu--> <div class="sidenav"> <div class="sidenav-content"> <div class="closebtn"><a class="menu-close">&times;</a></div> <nav class="navigation"> <div class="menu-top-navigation-container"><ul id="menu-top-navigation" class="mobile-nav"><li id="menu-item-1240" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-1240"><a href="https://genetics.med.upenn.edu/"><span>Home</span></a></li> <li id="menu-item-1226" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1226"><a href="https://genetics.med.upenn.edu/cores/"><span>Cores</span></a> <ul class="sub-menu"> <li id="menu-item-1243" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1243"><a href="https://genetics.med.upenn.edu/cores/cell-center-stockroom/">Cell Center Stockroom</a></li> <li id="menu-item-1242" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1242"><a href="https://genetics.med.upenn.edu/cores/cell-center-services/">Cell Center Services</a></li> <li id="menu-item-1229" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1229"><a href="https://genetics.med.upenn.edu/cores/pgsc/">Penn Genomic and Sequencing Core</a></li> <li id="menu-item-1227" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1227"><a href="https://genetics.med.upenn.edu/cores/genetic-diagnostic-laboratory/">Genetic Diagnostic Laboratory</a></li> <li id="menu-item-1230" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1230"><a href="https://genetics.med.upenn.edu/cores/tcmf/">Transgenic and Chimeric Mouse Facility</a></li> </ul> </li> <li id="menu-item-1239" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1239"><a href="https://genetics.med.upenn.edu/faculty/"><span>Faculty</span></a></li> <li id="menu-item-1231" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1231"><a href="https://genetics.med.upenn.edu/education/"><span>Education</span></a> <ul class="sub-menu"> <li id="menu-item-1237" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1237"><a href="https://genetics.med.upenn.edu/education/undergraduate/">Undergraduate Education</a></li> <li id="menu-item-1233" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1233"><a href="https://genetics.med.upenn.edu/education/graduate/">Graduate Studies</a></li> <li id="menu-item-1236" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1236"><a href="https://genetics.med.upenn.edu/education/postdoctoral/">Postdoctoral Programs</a></li> <li id="menu-item-1235" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1235"><a href="https://genetics.med.upenn.edu/education/post-baccalaureate/">Post-Baccalaureate Education</a></li> <li id="menu-item-1232" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1232"><a href="https://genetics.med.upenn.edu/education/training-grant/">Genetics Training Grant</a></li> <li id="menu-item-1234" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1234"><a href="https://genetics.med.upenn.edu/education/md-phd-program/">MD / PHD Programs</a></li> </ul> </li> <li id="menu-item-1241" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1241"><a href="https://genetics.med.upenn.edu/news/"><span>News</span></a> <ul class="sub-menu"> <li id="menu-item-1215" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-1215"><a href="https://genetics.med.upenn.edu/category/announcements/">Announcements</a></li> <li id="menu-item-1217" class="menu-item menu-item-type-taxonomy menu-item-object-category current-post-ancestor current-menu-parent current-post-parent menu-item-1217"><a href="https://genetics.med.upenn.edu/category/publications/">Publications</a></li> <li id="menu-item-1216" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-1216"><a href="https://genetics.med.upenn.edu/category/in-the-news/">In the News</a></li> </ul> </li> <li id="menu-item-1238" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1238"><a href="https://genetics.med.upenn.edu/events/"><span>Events</span></a></li> <li id="menu-item-1225" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1225"><a href="https://genetics.med.upenn.edu/contact/"><span>Contact</span></a></li> </ul></div> </nav> <div class="mobile-contact"> <div class="social"> <ul> <li> <a href="https://twitter.com/PennGenetics" target="_blank" title=""> <div class="social-icon"> <i class="fab fa-twitter" aria-hidden="true"></i> </div> </a> </li> </ul> </div> </div> </div> </div> <!--End Mobile Menu--> <!--Wrap--> <div id="wrap" class="clear width-100"> <header> <div class="logo-title-wrap clear"> <div class="inner-container clear"> <div class="site-title"> <div class="menu-open"><i class="fa fa-bars"></i></div> <a href="https://genetics.med.upenn.edu/">Department of Genetics</a> </div> <div class="perelman-logo"> <a href="https://www.med.upenn.edu/" target="_blank"> <img src="https://genetics.med.upenn.edu/wp-content/blogs.dir/66/files/sites/66/2020/02/psom-logo.png" alt="Perelman School of Medicine at the University of Pennsylvania" title="Perelman School of Medicine at the University of Pennsylvania" /> </a> </div> </div> </div> <div class="nav-wrap clear"> <nav class="navigation drops"><div class="menu-top-navigation-container"><ul id="menu-top-navigation-1" class="top-nav"><li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-1240"><a href="https://genetics.med.upenn.edu/"><span>Home</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1226"><a href="https://genetics.med.upenn.edu/cores/"><span>Cores</span></a> <ul class="sub-menu"> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1243"><a href="https://genetics.med.upenn.edu/cores/cell-center-stockroom/">Cell Center Stockroom</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1242"><a href="https://genetics.med.upenn.edu/cores/cell-center-services/">Cell Center Services</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1229"><a href="https://genetics.med.upenn.edu/cores/pgsc/">Penn Genomic and Sequencing Core</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1227"><a href="https://genetics.med.upenn.edu/cores/genetic-diagnostic-laboratory/">Genetic Diagnostic Laboratory</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1230"><a href="https://genetics.med.upenn.edu/cores/tcmf/">Transgenic and Chimeric Mouse Facility</a></li> </ul> </li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1239"><a href="https://genetics.med.upenn.edu/faculty/"><span>Faculty</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1231"><a href="https://genetics.med.upenn.edu/education/"><span>Education</span></a> <ul class="sub-menu"> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1237"><a href="https://genetics.med.upenn.edu/education/undergraduate/">Undergraduate Education</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1233"><a href="https://genetics.med.upenn.edu/education/graduate/">Graduate Studies</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1236"><a href="https://genetics.med.upenn.edu/education/postdoctoral/">Postdoctoral Programs</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1235"><a href="https://genetics.med.upenn.edu/education/post-baccalaureate/">Post-Baccalaureate Education</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1232"><a href="https://genetics.med.upenn.edu/education/training-grant/">Genetics Training Grant</a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1234"><a href="https://genetics.med.upenn.edu/education/md-phd-program/">MD / PHD Programs</a></li> </ul> </li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-1241"><a href="https://genetics.med.upenn.edu/news/"><span>News</span></a> <ul class="sub-menu"> <li class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-1215"><a href="https://genetics.med.upenn.edu/category/announcements/">Announcements</a></li> <li class="menu-item menu-item-type-taxonomy menu-item-object-category current-post-ancestor current-menu-parent current-post-parent menu-item-1217"><a href="https://genetics.med.upenn.edu/category/publications/">Publications</a></li> <li class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-1216"><a href="https://genetics.med.upenn.edu/category/in-the-news/">In the News</a></li> </ul> </li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1238"><a href="https://genetics.med.upenn.edu/events/"><span>Events</span></a></li> <li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-1225"><a href="https://genetics.med.upenn.edu/contact/"><span>Contact</span></a></li> </ul></div></nav> </div> </header><div id="page" class="body-wrap clear sub"> <main class="blogwrap"> <div class="inner-container blog-sidebar-wrap animatedParent animateOnceclear"> <div class="post-single the-content animated fadeInUpShort clear"> <h1 class="post-title">Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations</h1> <div class="date-social clear"> <div class="date">Posted On: January 27, 2020</div> <div class="social-share"> <ul class="social-links"> <li>Share:</li> <li> <a href="https://www.facebook.com/sharer/sharer.php?u=https://genetics.med.upenn.edu/integrative-analysis-reveals-rna-g-quadruplexes-in-utrs-are-selectively-constrained-and-enriched-for-functional-associations/" target="blank" title="Share on Facebook"> <i class="fab fa-facebook-f" aria-hidden="true"></i> </a> </li> <li> <a href="https://twitter.com/home?status=Check%20out%20this%20article:%20Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations%20https://genetics.med.upenn.edu/integrative-analysis-reveals-rna-g-quadruplexes-in-utrs-are-selectively-constrained-and-enriched-for-functional-associations/" target="blank" title="Share on Twitter"> <i class="fab fa-twitter" aria-hidden="true"></i> </a> </li> <li> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https://genetics.med.upenn.edu/integrative-analysis-reveals-rna-g-quadruplexes-in-utrs-are-selectively-constrained-and-enriched-for-functional-associations/&title=Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations" target="blank" title="Share on LinkedIn"> <i class="fab fa-linkedin" aria-hidden="true"></i> </a> </li> </ul> </div> </div> <p><strong><a class="in-cell-link" href="https://www.nature.com/articles/s41467-020-14404-y" target="_blank" rel="noopener noreferrer">Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations</a>. </strong>David S. M. Lee,聽Louis R. Ghanem聽&amp;聽Yoseph Barash</p> <div class="previous-next clear"> <div class="previous-post"><div class="left-arrow"><i class="fa fa-chevron-left"></i></div> Previous Post<br/> <a href="https://genetics.med.upenn.edu/african-centric-tp53-variant-increases-iron-accumulation-and-bacterial-pathogenesis-but-improves-response-to-malaria-toxin/" rel="prev">African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin</a></div> <div class="next-post"><div class="right-arrow"><i class="fa fa-chevron-right"></i></div>Next Post<br/> <a href="https://genetics.med.upenn.edu/an-ancient-baboon-genome-demonstrates-long-term-population-continuity-in-southern-africa/" rel="next">An Ancient Baboon Genome Demonstrates Long-Term Population Continuity in Southern Africa</a></div> </div> </div> <aside class="animated fadeInLeftShort"> <div class="latest-posts the-content"> <h3>Latest News</h3> <ul> <li> <a href="https://genetics.med.upenn.edu/new-department-of-genetics-website-in-progress/">Genetics Website in Progress</a> </li> <li> <a href="https://genetics.med.upenn.edu/single-cell-multi-omics-analysis-of-human-pancreatic-islets-reveals-novel-cellular-states-in-type-1-diabetes/">Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes</a> </li> <li> <a href="https://genetics.med.upenn.edu/single-cell-analysis-of-the-human-pancreas-in-type-2-diabetes-using-multi-spectral-imaging-mass-cytometry/">Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry</a> </li> <li> <a href="https://genetics.med.upenn.edu/temporal-manipulation-of-cdkl5-reveals-essential-postdevelopmental-functions-and-reversible-cdkl5-deficiency-disorder-related-deficits/">Temporal manipulation of Cdkl5 reveals essential postdevelopmental functions and reversible CDKL5 deficiency disorder鈥搑elated deficits</a> </li> </ul> </div> <div class="categories the-content"> <h3>Categories</h3> <ul class="archive"> <li class="cat-item cat-item-2"><a href="https://genetics.med.upenn.edu/category/announcements/">Announcements</a> </li> <li class="cat-item cat-item-3"><a href="https://genetics.med.upenn.edu/category/in-the-news/">In the News</a> </li> <li class="cat-item cat-item-4"><a href="https://genetics.med.upenn.edu/category/news/">News</a> </li> <li class="cat-item cat-item-5"><a href="https://genetics.med.upenn.edu/category/publications/">Publications</a> </li> <li class="cat-item cat-item-1"><a href="https://genetics.med.upenn.edu/category/uncategorized/">Uncategorized</a> </li> </ul> </div> </aside> </div> </main> </div> <footer class="clear"> <!--Footer Content--> <section class="footer-main clear"> <div class="columns-wrap clear"> <div class="map-info" style="background-image: url('https://genetics.med.upenn.edu/wp-content/blogs.dir/66/files/sites/66/2020/02/footer-bg.jpg');"> <div class="trans-bg clear"> <div class="map-info-wrap"> <div class="map"></div> <div class="info"><p>Department of Genetics<br /> Perelman School of Medicine<br /> Clinical Research Building 500<br /> 415 Curie Blvd.<br /> University of Pennsylvania<br /> Philadelphia, PA 19104</p> </div> </div> </div> </div> <div class="search-wrap the-content"> <div class="search clear"> <h4>Search</h4> <form role="search" method="get" id="searchform" class="searchform" action="https://genetics.med.upenn.edu/"> <div class="search-fields"> <input type="text" value="" name="s" id="s" placeholder="Search Penn Genetics..." /> <button type="submit" class="search-submit" title="Search"><i class="fa fa-search" aria-hidden="true"></i></button> </div> </form> </div> <div class="social clear"> <h4>Follow Us</h4> <ul> <li> <a href="https://twitter.com/PennGenetics" target="_blank" title=""> <div class="social-icon"> <i class="fab fa-twitter" aria-hidden="true"></i> </div> </a> </li> </ul> </div> </div> </div> <!--Copyright--> <div class="copyright clear"> <div>Copyright &copy; 2024</div> <div><p>The Trustees of the University of Pennsylvania. All Rights Reserved. Privacy Policy.</p> </div> </div> <!--End Copyright--> </section> <!--End Footer Content--> </footer> </div> <!-- End Wrap --> <a href="#0" class="cd-top" title="Return to Top" alt="Return to Top">Top</a> <link rel='stylesheet' id='font-awesome-css' href='https://use.fontawesome.com/releases/v5.15.4/css/all.css?ver=6.6.2' type='text/css' media='all' /> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/js/classie.js?ver=6.6.2" id="classie-js-js"></script> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/js/jquery.bxslider.min.js?ver=6.6.2" id="bxslider-js-js"></script> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/js/main.js?ver=6.6.2" id="main-js-js"></script> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/js/jquery.min.js?ver=6.6.2" id="jquery-new-js"></script> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/js/css3-animate-it.js?ver=6.6.2" id="animate-js-js"></script> <script type="text/javascript" src="https://genetics.med.upenn.edu/wp-content/themes/upenngenetics/js/lightbox.js?ver=6.6.2" id="lightbox-js-js"></script> </body> </html>

Pages: 1 2 3 4 5 6 7 8 9 10