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University of Manchester</a>, <a class="u-tcGrayDarker" href="https://manchester.academia.edu/Departments/Mechanical_Aerospace_and_civil_engineering/Documents">Mechanical, Aerospace and civil engineering</a>, <span class="u-tcGrayDarker">Graduate Student</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="yutong" data-follow-user-id="19104765" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="19104765"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">34</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">3</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;"><b>Address: </b>Manchester, Manchester, United Kingdom<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="19104765" href="https://www.academia.edu/Documents/in/Management"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://manchester.academia.edu/yutongsong","location":"/yutongsong","scheme":"https","host":"manchester.academia.edu","port":null,"pathname":"/yutongsong","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Management"]}" data-trace="false" data-dom-id="Pill-react-component-41e13525-3c8b-4087-aad8-7961c225589c"></div> <div id="Pill-react-component-41e13525-3c8b-4087-aad8-7961c225589c"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="19104765" href="https://www.academia.edu/Documents/in/Physics"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Physics"]}" data-trace="false" data-dom-id="Pill-react-component-8aa47fbf-e6be-44cc-8aa5-f613a780cf21"></div> <div id="Pill-react-component-8aa47fbf-e6be-44cc-8aa5-f613a780cf21"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="19104765" href="https://www.academia.edu/Documents/in/Project_Management"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Project Management"]}" data-trace="false" data-dom-id="Pill-react-component-2a7df443-841a-41e2-90c5-318232e8c68b"></div> <div id="Pill-react-component-2a7df443-841a-41e2-90c5-318232e8c68b"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="19104765" href="https://www.academia.edu/Documents/in/Construction_Project_Management"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Construction Project Management"]}" data-trace="false" data-dom-id="Pill-react-component-5390a084-80b4-4dd8-9486-2ac5de3e6778"></div> <div id="Pill-react-component-5390a084-80b4-4dd8-9486-2ac5de3e6778"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="19104765" href="https://www.academia.edu/Documents/in/Political_Campaigns"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Political Campaigns"]}" data-trace="false" data-dom-id="Pill-react-component-5cf059df-0112-4086-be7c-664b7b1be395"></div> <div id="Pill-react-component-5cf059df-0112-4086-be7c-664b7b1be395"></div> </a></div></div><div class="external-links-container"><ul class="profile-links new-profile js-UserInfo-social"><li class="profile-profiles js-social-profiles-container"><i class="fa fa-spin fa-spinner"></i></li></ul></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by yutong song</h3></div><div class="js-work-strip profile--work_container" data-work-id="8810583"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/8810583/High_frequency_of_p53_intronic_point_mutations_in_laryngeal_squamous_cell_carcinoma"><img alt="Research paper thumbnail of High frequency of p53 intronic point mutations in laryngeal squamous cell carcinoma" class="work-thumbnail" src="https://attachments.academia-assets.com/35156223/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/8810583/High_frequency_of_p53_intronic_point_mutations_in_laryngeal_squamous_cell_carcinoma">High frequency of p53 intronic point mutations in laryngeal squamous cell carcinoma</a></div><div class="wp-workCard_item"><span>Progress in Natural Science</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This paper presents a framework for characterising project complexity in large engineering projec...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This paper presents a framework for characterising project complexity in large engineering projects, which can be used to adapt the front-end development phase of engineering projects to the particular complexity. Recently, a large number of project complexity related papers were published, demonstrating the evident importance of "complexity" in current project management research. However, no generally accepted framework is available to support the characterising and understanding of project complexity that appreciates the richness of project complexity in large engineering projects. Therefore the TOE (Technical, Organizational, and Environmental) framework was developed, based on a literature survey building upon existing work and on new empirical work consisting of eighteen interviews about six projects in the process engineering industry. As a result of an inductive approach, this framework presents the elements that contribute to project complexity from a theoretical as well as a practical perspective. The framework can be used to assess the complexity of engineering projects, and subsequently adapt the front-end development phase of projects in order to better manage the complexity of the project.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6eff94c3963d26c66be438510c3cb20b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":35156223,"asset_id":8810583,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/35156223/download_file?st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="8810583"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="8810583"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 8810583; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=8810583]").text(description); $(".js-view-count[data-work-id=8810583]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 8810583; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='8810583']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 8810583, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6eff94c3963d26c66be438510c3cb20b" } } $('.js-work-strip[data-work-id=8810583]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":8810583,"title":"High frequency of p53 intronic point mutations in laryngeal squamous cell carcinoma","translated_title":"","metadata":{"grobid_abstract":"This paper presents a framework for characterising project complexity in large engineering projects, which can be used to adapt the front-end development phase of engineering projects to the particular complexity. 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Here, we report that glutamate increases astrocyte water permeability and that the molecular target for this effect is the aquaporin-4 (AQP4) serine 111 residue, which is in a strategic position for control of the water channel gating. The glutamate effect involves activation of group I metabotropic glutamate receptors (mGluR), intracellular calcium release, and activation of calcium/calmodulin-dependent protein kinase II (CaMKII) and nitric oxide synthase (NOS). The physiological impact of our results is underlined by the finding that mGluR activation increases the rate of hypoosmotic tissue swelling in acute rat hippocampal slices. Cerebral ischemia is associated with an excessive release of glutamate, and in postischemic cerebral edema ablation of AQP4 attenuates the degree of damage. Thus, we have identified AQP4 as the molecular target for drugs that may attenuate the development of brain edema. 漏 2008 Wiley-Liss, Inc.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="48eb1976b136fc26bcf5fb61a6fe7b51" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":35156220,"asset_id":8810581,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/35156220/download_file?st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="8810581"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="8810581"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 8810581; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=8810581]").text(description); $(".js-view-count[data-work-id=8810581]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 8810581; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='8810581']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 8810581, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "48eb1976b136fc26bcf5fb61a6fe7b51" } } $('.js-work-strip[data-work-id=8810581]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":8810581,"title":"Identification of a molecular target for glutamate regulation of astrocyte water permeability","translated_title":"","metadata":{"abstract":"Astrocytes play a key role for maintenance of brain water homeostasis, but little is known about mechanisms of short-term regulation of astrocyte water permeability. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="8810579"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/8810579/Erythropoietin_modulation_of_astrocyte_water_permeability_as_a_component_of_neuroprotection"><img alt="Research paper thumbnail of Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection" class="work-thumbnail" src="https://attachments.academia-assets.com/35156212/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/8810579/Erythropoietin_modulation_of_astrocyte_water_permeability_as_a_component_of_neuroprotection">Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection</a></div><div class="wp-workCard_item"><span>Proceedings of The National Academy of Sciences</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose -The purpose of this paper is to scrutinize the influence of the highly cited Organizatio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose -The purpose of this paper is to scrutinize the influence of the highly cited Organization Theory and Project Management on consequent project research and to highlight the key contributions of the book, how it has affected consequent project research and to identify areas that could be further explored in future research. Design/methodology/approach -The paper takes the form of a book review and literature analysis. Findings -It is found that the book offers insights to elaborating the salient characteristics of large, complex and uncertain projects. It identifies the underlying theories and concepts to improve our understanding of the three main issues: the sources of uncertainty in large engineering intensive projects; management and governance approaches utilized to tackle uncertainty; and project routines and innovation. Some of these insights have later been acknowledged by project scholars focusing topics such as project governance and the management of uncertainty in projects. Practical implications -The book offers several insights and lessons to scholars and practitioners working with large engineering intensive projects. Originality/value -The contribution of the book is not used to its full potential in project research.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f6ca40fe9cfd7c00d4ec1547cc76886f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":35156212,"asset_id":8810579,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/35156212/download_file?st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="8810579"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="8810579"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 8810579; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=8810579]").text(description); $(".js-view-count[data-work-id=8810579]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 8810579; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='8810579']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 8810579, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f6ca40fe9cfd7c00d4ec1547cc76886f" } } $('.js-work-strip[data-work-id=8810579]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":8810579,"title":"Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection","translated_title":"","metadata":{"grobid_abstract":"Purpose -The purpose of this paper is to scrutinize the influence of the highly cited Organization Theory and Project Management on consequent project research and to highlight the key contributions of the book, how it has affected consequent project research and to identify areas that could be further explored in future research. 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Recently, a large number of project complexity related papers were published, demonstrating the evident importance of "complexity" in current project management research. However, no generally accepted framework is available to support the characterising and understanding of project complexity that appreciates the richness of project complexity in large engineering projects. Therefore the TOE (Technical, Organizational, and Environmental) framework was developed, based on a literature survey building upon existing work and on new empirical work consisting of eighteen interviews about six projects in the process engineering industry. As a result of an inductive approach, this framework presents the elements that contribute to project complexity from a theoretical as well as a practical perspective. The framework can be used to assess the complexity of engineering projects, and subsequently adapt the front-end development phase of projects in order to better manage the complexity of the project.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b779e488e28471be026e8d4f88566a50" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":35156203,"asset_id":8810577,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/35156203/download_file?st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="8810577"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="8810577"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 8810577; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=8810577]").text(description); $(".js-view-count[data-work-id=8810577]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 8810577; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='8810577']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 8810577, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b779e488e28471be026e8d4f88566a50" } } $('.js-work-strip[data-work-id=8810577]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":8810577,"title":"Grasping project complexity in large engineering projects: The TOE (Technical, Organizational and Environmental) framework","translated_title":"","metadata":{"grobid_abstract":"This paper presents a framework for characterising project complexity in large engineering projects, which can be used to adapt the front-end development phase of engineering projects to the particular complexity. 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Recently, a large number of project complexity related papers were published, demonstrating the evident importance of "complexity" in current project management research. However, no generally accepted framework is available to support the characterising and understanding of project complexity that appreciates the richness of project complexity in large engineering projects. Therefore the TOE (Technical, Organizational, and Environmental) framework was developed, based on a literature survey building upon existing work and on new empirical work consisting of eighteen interviews about six projects in the process engineering industry. As a result of an inductive approach, this framework presents the elements that contribute to project complexity from a theoretical as well as a practical perspective. The framework can be used to assess the complexity of engineering projects, and subsequently adapt the front-end development phase of projects in order to better manage the complexity of the project.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6eff94c3963d26c66be438510c3cb20b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":35156223,"asset_id":8810583,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/35156223/download_file?st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="8810583"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="8810583"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 8810583; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=8810583]").text(description); $(".js-view-count[data-work-id=8810583]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 8810583; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='8810583']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 8810583, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6eff94c3963d26c66be438510c3cb20b" } } $('.js-work-strip[data-work-id=8810583]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":8810583,"title":"High frequency of p53 intronic point mutations in laryngeal squamous cell carcinoma","translated_title":"","metadata":{"grobid_abstract":"This paper presents a framework for characterising project complexity in large engineering projects, which can be used to adapt the front-end development phase of engineering projects to the particular complexity. Recently, a large number of project complexity related papers were published, demonstrating the evident importance of \"complexity\" in current project management research. However, no generally accepted framework is available to support the characterising and understanding of project complexity that appreciates the richness of project complexity in large engineering projects. Therefore the TOE (Technical, Organizational, and Environmental) framework was developed, based on a literature survey building upon existing work and on new empirical work consisting of eighteen interviews about six projects in the process engineering industry. As a result of an inductive approach, this framework presents the elements that contribute to project complexity from a theoretical as well as a practical perspective. 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Recently, a large number of project complexity related papers were published, demonstrating the evident importance of \"complexity\" in current project management research. However, no generally accepted framework is available to support the characterising and understanding of project complexity that appreciates the richness of project complexity in large engineering projects. Therefore the TOE (Technical, Organizational, and Environmental) framework was developed, based on a literature survey building upon existing work and on new empirical work consisting of eighteen interviews about six projects in the process engineering industry. As a result of an inductive approach, this framework presents the elements that contribute to project complexity from a theoretical as well as a practical perspective. The framework can be used to assess the complexity of engineering projects, and subsequently adapt the front-end development phase of projects in order to better manage the complexity of the project.","owner":{"id":19104765,"first_name":"yutong","middle_initials":null,"last_name":"song","page_name":"yutongsong","domain_name":"manchester","created_at":"2014-10-16T02:33:23.563-07:00","display_name":"yutong song","url":"https://manchester.academia.edu/yutongsong"},"attachments":[{"id":35156223,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/35156223/thumbnails/1.jpg","file_name":"project_failure.pdf","download_url":"https://www.academia.edu/attachments/35156223/download_file?st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"High_frequency_of_p53_intronic_point_mut.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/35156223/project_failure-libre.pdf?1413452152=\u0026response-content-disposition=attachment%3B+filename%3DHigh_frequency_of_p53_intronic_point_mut.pdf\u0026Expires=1733961486\u0026Signature=WdnQ5jovdhHbO0Zk2Lv8OmDwnCuN08o9M-QXYJnbWIzEZuOyRPFClwmfuQrBBZuPCHkeaK2sCINSwBmO6ZiOKFTVWePT7ZGgZPu4d4BUiAZOPc7mDyrW6ml6kxgGAsv5DmWgludyNrp2WMxm5-sBKrVa6w9BnjCaWIzXpRhfD76SRhxxERw1TxDztXpOZEfSL7kLFIUQJyXalKfIIpJqCi0WdxPalYPVehiCWF1Ihq8obfA5syovASgPeJpHzFHQ8kYbgxuforxxJrZB8pts20MGeYEE1gEDmQHTJfqbiGm9cXOtFpBstRGSyDvqmro2f49wl0mdwgC5t5BczPzvig__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":498,"name":"Physics","url":"https://www.academia.edu/Documents/in/Physics"}],"urls":[{"id":3655429,"url":"http://www.informaworld.com/openurl?genre=article\u0026doi=10.1080/10020070412331343991\u0026magic=crossref%7C%7CD404A21C5BB053405B1A640AFFD44AE3"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="8810581"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/8810581/Identification_of_a_molecular_target_for_glutamate_regulation_of_astrocyte_water_permeability"><img alt="Research paper thumbnail of Identification of a molecular target for glutamate regulation of astrocyte water permeability" class="work-thumbnail" src="https://attachments.academia-assets.com/35156220/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/8810581/Identification_of_a_molecular_target_for_glutamate_regulation_of_astrocyte_water_permeability">Identification of a molecular target for glutamate regulation of astrocyte water permeability</a></div><div class="wp-workCard_item"><span>Glia</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Astrocytes play a key role for maintenance of brain water homeostasis, but little is known about ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Astrocytes play a key role for maintenance of brain water homeostasis, but little is known about mechanisms of short-term regulation of astrocyte water permeability. Here, we report that glutamate increases astrocyte water permeability and that the molecular target for this effect is the aquaporin-4 (AQP4) serine 111 residue, which is in a strategic position for control of the water channel gating. The glutamate effect involves activation of group I metabotropic glutamate receptors (mGluR), intracellular calcium release, and activation of calcium/calmodulin-dependent protein kinase II (CaMKII) and nitric oxide synthase (NOS). The physiological impact of our results is underlined by the finding that mGluR activation increases the rate of hypoosmotic tissue swelling in acute rat hippocampal slices. Cerebral ischemia is associated with an excessive release of glutamate, and in postischemic cerebral edema ablation of AQP4 attenuates the degree of damage. Thus, we have identified AQP4 as the molecular target for drugs that may attenuate the development of brain edema. 漏 2008 Wiley-Liss, Inc.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="48eb1976b136fc26bcf5fb61a6fe7b51" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":35156220,"asset_id":8810581,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/35156220/download_file?st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="8810581"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="8810581"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 8810581; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=8810581]").text(description); $(".js-view-count[data-work-id=8810581]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 8810581; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='8810581']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 8810581, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "48eb1976b136fc26bcf5fb61a6fe7b51" } } $('.js-work-strip[data-work-id=8810581]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":8810581,"title":"Identification of a molecular target for glutamate regulation of astrocyte water permeability","translated_title":"","metadata":{"abstract":"Astrocytes play a key role for maintenance of brain water homeostasis, but little is known about mechanisms of short-term regulation of astrocyte water permeability. Here, we report that glutamate increases astrocyte water permeability and that the molecular target for this effect is the aquaporin-4 (AQP4) serine 111 residue, which is in a strategic position for control of the water channel gating. The glutamate effect involves activation of group I metabotropic glutamate receptors (mGluR), intracellular calcium release, and activation of calcium/calmodulin-dependent protein kinase II (CaMKII) and nitric oxide synthase (NOS). The physiological impact of our results is underlined by the finding that mGluR activation increases the rate of hypoosmotic tissue swelling in acute rat hippocampal slices. Cerebral ischemia is associated with an excessive release of glutamate, and in postischemic cerebral edema ablation of AQP4 attenuates the degree of damage. 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The physiological impact of our results is underlined by the finding that mGluR activation increases the rate of hypoosmotic tissue swelling in acute rat hippocampal slices. Cerebral ischemia is associated with an excessive release of glutamate, and in postischemic cerebral edema ablation of AQP4 attenuates the degree of damage. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="8810579"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/8810579/Erythropoietin_modulation_of_astrocyte_water_permeability_as_a_component_of_neuroprotection"><img alt="Research paper thumbnail of Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection" class="work-thumbnail" src="https://attachments.academia-assets.com/35156212/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/8810579/Erythropoietin_modulation_of_astrocyte_water_permeability_as_a_component_of_neuroprotection">Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection</a></div><div class="wp-workCard_item"><span>Proceedings of The National Academy of Sciences</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Purpose -The purpose of this paper is to scrutinize the influence of the highly cited Organizatio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Purpose -The purpose of this paper is to scrutinize the influence of the highly cited Organization Theory and Project Management on consequent project research and to highlight the key contributions of the book, how it has affected consequent project research and to identify areas that could be further explored in future research. Design/methodology/approach -The paper takes the form of a book review and literature analysis. Findings -It is found that the book offers insights to elaborating the salient characteristics of large, complex and uncertain projects. It identifies the underlying theories and concepts to improve our understanding of the three main issues: the sources of uncertainty in large engineering intensive projects; management and governance approaches utilized to tackle uncertainty; and project routines and innovation. Some of these insights have later been acknowledged by project scholars focusing topics such as project governance and the management of uncertainty in projects. Practical implications -The book offers several insights and lessons to scholars and practitioners working with large engineering intensive projects. Originality/value -The contribution of the book is not used to its full potential in project research.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f6ca40fe9cfd7c00d4ec1547cc76886f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":35156212,"asset_id":8810579,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/35156212/download_file?st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="8810579"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="8810579"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 8810579; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=8810579]").text(description); $(".js-view-count[data-work-id=8810579]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 8810579; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='8810579']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 8810579, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f6ca40fe9cfd7c00d4ec1547cc76886f" } } $('.js-work-strip[data-work-id=8810579]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":8810579,"title":"Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection","translated_title":"","metadata":{"grobid_abstract":"Purpose -The purpose of this paper is to scrutinize the influence of the highly cited Organization Theory and Project Management on consequent project research and to highlight the key contributions of the book, how it has affected consequent project research and to identify areas that could be further explored in future research. 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Recently, a large number of project complexity related papers were published, demonstrating the evident importance of "complexity" in current project management research. However, no generally accepted framework is available to support the characterising and understanding of project complexity that appreciates the richness of project complexity in large engineering projects. Therefore the TOE (Technical, Organizational, and Environmental) framework was developed, based on a literature survey building upon existing work and on new empirical work consisting of eighteen interviews about six projects in the process engineering industry. As a result of an inductive approach, this framework presents the elements that contribute to project complexity from a theoretical as well as a practical perspective. The framework can be used to assess the complexity of engineering projects, and subsequently adapt the front-end development phase of projects in order to better manage the complexity of the project.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b779e488e28471be026e8d4f88566a50" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":35156203,"asset_id":8810577,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/35156203/download_file?st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&st=MTczMzk1Nzg4Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="8810577"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="8810577"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 8810577; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=8810577]").text(description); $(".js-view-count[data-work-id=8810577]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 8810577; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='8810577']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 8810577, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b779e488e28471be026e8d4f88566a50" } } $('.js-work-strip[data-work-id=8810577]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":8810577,"title":"Grasping project complexity in large engineering projects: The TOE (Technical, Organizational and Environmental) framework","translated_title":"","metadata":{"grobid_abstract":"This paper presents a framework for characterising project complexity in large engineering projects, which can be used to adapt the front-end development phase of engineering projects to the particular complexity. 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