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Diabetes - Mass General Advances in Motion
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-padding--horizontal -padding--vertical -background--blue"> <div class="layout-columns__sidebar__content"> <h1 class="sidebar-heading"> <span class="sidebar-heading__subheading">Topic</span>Diabetes </h1> </div> </div> <div class="layout-columns__main -padding--vertical -padding--horizontal"> <div class="layout-columns__main__content"> <ul class="content-tease__list"> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/endocrinology/journal.aspx?id=2202" itemprop="url"> Newly Identified Genetic Variant Has Substantial Effect on Risk of Type 2 Diabetes</a> </h3> <p itemprop="description"> <p><span>Most genome-wide association studies (GWAS) are likely to miss variants with recessive effects. In a large recessive-model GWAS, Massachusetts General Hospital researchers identified a novel locus associated with 2.56 greater risk of type 2 diabetes in homozygous carriers that also had substantial effects on lipids.</span></p></p> <p class="content-tease__related"> <a href="/endocrinology/topic.aspx?id=1105" itemprop="relatedLink">Diabetes</a>, <a href="/endocrinology/specialty.aspx?id=1015" itemprop="relatedLink">Endocrinology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2022-04-19" itemprop="datePublished">April 19, 2022</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/endocrinology/article-external.aspx?id=1168" itemprop="url"> Bionic Pancreas Improves Glycemic Control in Patients With Cystic Fibrosis-related Diabetes</a> </h3> <p itemprop="description"> <p>Melissa Putman, MD, Jordan Sherwood, MD, and colleagues report that the insulin-only iLet bionic pancreas improved glucose control in patients with cystic fibrosis-related diabetes (CFRD) compared to usual care, without an increase in continuous glucose monitoring-measured hypoglycemia.</p></p> <p class="content-tease__related"> <a href="/endocrinology/topic.aspx?id=1105" itemprop="relatedLink">Diabetes</a>, <a href="/endocrinology/specialty.aspx?id=1015" itemprop="relatedLink">Endocrinology</a>, <a href="/pulmonary/specialty.aspx?id=1012" itemprop="relatedLink">Pulmonary and Critical Care</a> </p> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2024-08-14" itemprop="datePublished">August 14, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/ortho/journal.aspx?id=2635" itemprop="url"> HbA1c Levels >6.6% Linked to Greater Risk of Repeat Surgery After ACL Reconstruction</a> </h3> <p itemprop="description"> <p><span>Ophelie Lavoie-Gagne, MD, Miho J. Tanaka, MD, PhD, and colleagues conducted the first study of how preoperative glycemic control affects outcomes of ACL reconstruction, finding HbA1c ≥6.7% increases the risk of any surgical complication by 66% and increases the need for reoperation for surgical complications by 45%.</span></p></p> <p class="content-tease__related"> <a href="/endocrinology/topic.aspx?id=1105" itemprop="relatedLink">Diabetes</a>, <a href="/ortho/topic.aspx?id=1007" itemprop="relatedLink">Hip and Knee</a>, <a href="/ortho/specialty.aspx?id=1003" itemprop="relatedLink">Orthopaedics</a>, <a href="/ortho/topic.aspx?id=1009" itemprop="relatedLink">Sports Medicine</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-07-11" itemprop="datePublished">July 11, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/endocrinology/journal.aspx?id=2620" itemprop="url"> Continuous Glucose Monitoring Predicts Long-term Nutritional Outcomes in Adults With Cystic Fibrosis</a> </h3> <p itemprop="description"> <p><span>Melissa S. Putman, MD, and colleagues correlated findings on continuous glucose monitoring with a decline in body weight and a decline in body mass index over one year in adults with cystic fibrosis. Their data also suggest advanced glycation end products may represent a useful marker in this population.</span></p></p> <p class="content-tease__related"> <a href="/endocrinology/topic.aspx?id=1105" itemprop="relatedLink">Diabetes</a>, <a href="/endocrinology/specialty.aspx?id=1015" itemprop="relatedLink">Endocrinology</a>, <a href="/pulmonary/specialty.aspx?id=1012" itemprop="relatedLink">Pulmonary and Critical Care</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-05-13" itemprop="datePublished">May 13, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/cardiovascular/journal.aspx?id=2609" itemprop="url"> Cardiorenal Biomarkers Predict Major Complications in Patients With Type 2 Diabetes and Chronic Kidney Disease</a> </h3> <p itemprop="description"> <p><span>James L. Januzzi, MD, and colleagues showed that among people with type 2 diabetes and albuminuria, baseline and follow-up concentrations of four biomarkers of cardiorenal stress individually and collectively predicted the risk of heart failure, progression of kidney disease, and related outcomes.</span></p></p> <p class="content-tease__related"> <a href="/cardiovascular/specialty.aspx?id=1002" itemprop="relatedLink">Cardiovascular</a>, <a href="/endocrinology/topic.aspx?id=1105" itemprop="relatedLink">Diabetes</a>, <a href="/cardiovascular/topic.aspx?id=1003" itemprop="relatedLink">Heart Failure</a>, <a href="/urology/topic.aspx?id=1026" itemprop="relatedLink">Kidney</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-04-15" itemprop="datePublished">April 15, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=2579" itemprop="url"> Tobacco Use and Type 2 Diabetes Have Additive Effect on Risk of Fibrosis in Patients With MASLD</a> </h3> <p itemprop="description"> <p><span>Oluwafemi Balogun, MBBS, MPH, Kathleen E. Corey, MD, MPH, MMSc, and colleagues demonstrated that smoking and underlying type 2 diabetes mellitus (T2DM) have a synergistic effect on the severity of fibrosis, nearly doubling the risk (OR, 1.88; P=0.0037) compared with nonsmokers who do not have T2DM.</span></p></p> <p class="content-tease__related"> <a href="/endocrinology/topic.aspx?id=1105" itemprop="relatedLink">Diabetes</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a>, <a href="/digestive-health/topic.aspx?id=1071" itemprop="relatedLink">Liver</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-01-29" itemprop="datePublished">January 29, 2024</time> </p> </div> </li> </ui> <p class="fat-link__cta u-flush u-text-right"> <a class="fat-link -caret -large" href="https://advances.massgeneral.org/search.aspx?q=*&st=1&topic=diabetes&maxResults=15">View all Diabetes updates</a> </p> </div> </div> </section> <section class="-background--grey -padding--vertical -padding--horizontal"> <div class="content-container -width--wide -centered"> <h2 class="section-heading -centered">Diabetes Contributors</h2> <ul class="profile-card__list" id="profile-cards"> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/camille-Powe_advances.png, /assets/images/contributors/camille-Powe_advances_2x.png 2x" src="/assets/images/contributors/camille-Powe_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1665" itemprop="url">Camille E. Powe, MD</a> </h3> <p itemprop="jobTitle"> Endocrinologist, Massachusetts General Hospital, Co-Director, Diabetes in Pregnancy Program</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/obgyn/journal.aspx?id=2041">Carbohydrate Intake Before Oral Glucose Tolerance Test May Prevent Accurate Diagnosis of Gestational Diabetes</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/camille-Powe_advances.png, /assets/images/contributors/camille-Powe_advances_2x.png 2x" src="/assets/images/contributors/camille-Powe_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/jose_flores_advances.png, /assets/images/contributors/jose_flores_advances_2x.png 2x" src="/assets/images/contributors/jose_flores_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=2158" itemprop="url">Jose C. Florez, MD, PhD</a> </h3> <p itemprop="jobTitle"> Chief, Diabetes Unit, Endocrine Division, John T. Potts Jr., MD Endowed Chair in Medicine, Massachusetts General Hospital, Professor of Medicine, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/endocrinology/journal.aspx?id=2202">Newly Identified Genetic Variant Has Substantial Effect on Risk of Type 2 Diabetes</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/jose_flores_advances.png, /assets/images/contributors/jose_flores_advances_2x.png 2x" src="/assets/images/contributors/jose_flores_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1865" itemprop="url">Josep M. Mercader, PhD</a> </h3> <p itemprop="jobTitle"> Research-Scientist, Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/endocrinology/journal.aspx?id=2333">Cardiometabolic Protein Biomarkers Help With Risk Stratification of COVID-19 Patients</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset=", 2x" src=""> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=2026" itemprop="url">Melissa S. Putman, MD</a> </h3> <p itemprop="jobTitle"> Endocrinologist, Massachusetts General Hospital, Assistant Professor of Pediatrics, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/endocrinology/article-external.aspx?id=1168">Bionic Pancreas Improves Glycemic Control in Patients With Cystic Fibrosis-related Diabetes</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset=", 2x" src=""> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1864" itemprop="url">Si Arn Aaron Leong, MD, MSc</a> </h3> <p itemprop="jobTitle"> Endocrinologist, Diabetes Unit, Massachusetts General Hospital</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/endocrinology/journal.aspx?id=2333">Cardiometabolic Protein Biomarkers Help With Risk Stratification of COVID-19 Patients</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset=", 2x" src=""> </p> </li> </ul> <p class="fat-link__wrapper u-text-centered"> <button class="fat-link -plus -large" data-module="view-cards" data-target="#profile-cards" data-show="4">Diabetes Contributors</button> </p> </div> </section> <div class="content-container -width--xwide -centered specialty-block__wrapper" id="specialty-block"> <style> #specialty-block .specialty-block__image { /* 540px */ background-image: url(/assets/raw/specialty-block/endo-specialty-1200.png); } only screen and (-webkit-min-device-pixel-ratio: 2), only screen and (min--moz-device-pixel-ratio: 2), only screen and (-moz-min-device-pixel-ratio: 2), only screen and (-o-min-device-pixel-ratio: 2/1), only screen and (min-device-pixel-ratio: 2), only screen and (min-resolution: 192dpi), only screen and (min-resolution: 2dppx) { #specialty-block .specialty-block__image { /* 1080 width */ 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