SciELO Brasil - Assessment of patient’s anxiety and expectation associated with hemodynamic changes during surgical procedure under local anesthesia Assessment of patient’s anxiety and expectation associated with hemodynamic changes during surgical procedure under local anesthesia

<!DOCTYPE html>     <html class="no-js" lang="pt-BR" xmlns:mml="http://www.w3.org/1998/Math/MathML">  <head> <meta charset="utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="viewport" content="width=device-width, initial-scale=1, maximum-scale=1.0"> <title>SciELO Brasil - Assessment of patient’s anxiety and expectation associated with hemodynamic changes during surgical procedure under local anesthesia Assessment of patient’s anxiety and expectation associated with hemodynamic changes during surgical procedure under local anesthesia </title>  <meta property="og:url" content="https://www.scielo.br/j/rounesp/a/tjKGtmnFK4ZJmbYBctVvddh/?lang=en"/> <meta property="og:type" content="article"/> <meta property="og:title" content="Assessment of patient’s anxiety and expectation associated with hemodynamic changes during surgical procedure under local anesthesia"/> <meta property="og:description" content="Abstract Introduction The dental patient’s anxiety and expectation may significantly alter their..."/> <meta property="og:image" content="https://www.scielo.br/media/images/rounesp_glogo.gif"/>  <meta name="citation_author" content="DANTAS, Marcos Vinícius Mendes"></meta> <meta name="citation_author" content="NESSO, Bianca"></meta> <meta name="citation_author" content="MITUUTI, Daniel Sagawa"></meta> <meta name="citation_author" content="GABRIELLI, Marisa Aparecida Cabrini"></meta> <meta name="citation_journal_title" content="Revista de Odontologia da UNESP"></meta> <meta name="citation_journal_abbrev" content="Rev. odontol. UNESP"></meta> <meta name="citation_journal_abbrev" content="Rev. odontol. UNESP"></meta> <meta name="citation_publisher" content="Universidade Estadual Paulista Júlio de Mesquita Filho"></meta> <meta name="citation_volume" content="46"></meta> <meta name="citation_number" content="5"></meta> <meta name="citation_pdf_url" content="https://www.scielo.br/j/rounesp/a/tjKGtmnFK4ZJmbYBctVvddh/?lang=en&format=pdf"></meta> <meta name="citation_xml_url" content="https://www.scielo.br/j/rounesp/a/tjKGtmnFK4ZJmbYBctVvddh/?format=xml&lang=en"></meta> <meta name="citation_firstpage" content="299"></meta> <meta name="citation_lastpage" content="306"></meta> <meta name="citation_doi" content="10.1590/1807-2577.02917"></meta> <meta name="citation_fulltext_world_readable" content=""></meta> <meta name="citation_issn" content="0101-1774"></meta> <meta name="citation_issn" content="1807-2577"></meta> <meta name="citation_title" content="Assessment of patient’s anxiety and expectation associated with hemodynamic changes during surgical procedure under local anesthesia"></meta> <meta name="citation_language" content="en"></meta> <meta name="citation_abstract" content="Abstract Introduction The dental patient’s anxiety and expectation may significantly alter their vital signs. The use of local anesthetics associated with a vasoconstrictor may also alter the vital signs of these patients, promoting hemodynamic changes that may result in emergency situations. Objective To evaluate the influence of anxiety of patients submitted to third molar extraction and the use of different anesthetic substances with adrenaline on their vital signs (oxygen saturation, heart rate, and systolic and diastolic blood pressure) in different moments. Material and method Forty patients answered the questionnaire of the Dental Anxiety Scale (Corah’s Scale) and fear (KleinKnecht’s Scale) and were submitted to third molar extraction in two surgical times for the use of articaine or mepivacaine, both associated with adrenaline. The results were analyzed by ANOVA followed by Tukey post hoc test, Student's t test, and Pearson's correlation coefficients (α=0.05). Result There was no significant differences in saturation or heart rate. The blood pressure showed significant variations during time for both anesthetics, however mepivacaine resulted in a longer postoperative time to restore blood pressure. Patients with high or moderate anxiety and high fear index were those who had positive correlations with the highest blood pressure values. Conclusion Anxiety and fear positively influence the increase in blood pressure. Mepivacaine promoted a greater resistance to the return of normal vital signs, especially blood pressure levels."></meta> <meta name="citation_article_type" content="research-article"></meta> <meta name="citation_publication_date" content="2017-Sep-Oct"></meta> <meta name="citation_keywords" content="Anxiety"></meta><meta name="citation_keywords" content="fear"></meta><meta name="citation_keywords" content="vital signs"></meta><meta name="citation_keywords" content="blood pressure"></meta><meta name="citation_keywords" content="local anesthetic"></meta> <link rel="icon" href="/static/img/favicon.ico" /> <link href="/static/css/bootstrap.css?v=1.1.11" rel="stylesheet">    <div class="widget widget-Lockss widget-instance-IssueBrowseByYear_Lockss"> <input class="at-locks-messaging" type="hidden" value="LOCKSS system has permission to collect, preserve, and serve this Archival Unit" /> <input class="at-clockss-messaging" type="hidden" value="CLOCKSS system has permission to ingest, 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Odontol. UNESP 46 (5) <span class="_separator"> • </span>Oct 2017</span><span class="_separator"> • </span><span class="group-doi"><a href="https://doi.org/10.1590/1807-2577.02917" class="_doi" target="_blank">https://doi.org/10.1590/1807-2577.02917</a> <a href="javascript:;" class="btn btn-secondary btn-sm scielo__btn-with-icon--left copyLink" data-clipboard-text="https://doi.org/10.1590/1807-2577.02917"><span class="material-icons-outlined">link</span>copy</a></span> </div> <h1 class="article-title"> <img alt="Open-access" class="logo-open-access" data-bs-toggle="tooltip" src="https://ds.scielo.org/img/logo-open-access.svg" data-original-title="by 4.0 "> Assessment of patient’s anxiety and expectation associated with hemodynamic changes during surgical procedure under local anesthesia<a id="shorten" href="#" class="short-link"><span class="sci-ico-link"></span></a> </h1> <h2 class="article-title">Avaliação da ansiedade e da expectativa do paciente associadas às alterações hemodinâmicas durante procedimento cirúrgico sob anestesia local</h2> <div class="articleMeta"></div> <div class="scielo__contribGroup"> <a href="" class="btn btn-secondary btn-sm outlineFadeLink" data-bs-toggle="modal" data-bs-target="#ModalTutors">Authorship</a><a href="" class="btn btn-secondary btn-sm outlineFadeLink" data-bs-toggle="modal" data-bs-target="#ModalScimago">SCIMAGO INSTITUTIONS RANKINGS</a> </div> <div class="row"> <ul class="d-none d-lg-block col-lg-2 articleMenu"></ul> <article id="articleText" class="col-sm-12 col-lg-10 offset-lg-2"><div class="articleSection articleSection--abstract" data-anchor="Abstract"> <h3 class="h5">Abstract</h3> <p> <strong>Introduction</strong> The dental patient’s anxiety and expectation may significantly alter their vital signs. The use of local anesthetics associated with a vasoconstrictor may also alter the vital signs of these patients, promoting hemodynamic changes that may result in emergency situations. </p> <p> <strong>Objective</strong> To evaluate the influence of anxiety of patients submitted to third molar extraction and the use of different anesthetic substances with adrenaline on their vital signs (oxygen saturation, heart rate, and systolic and diastolic blood pressure) in different moments. </p> <p> <strong>Material and method</strong> Forty patients answered the questionnaire of the Dental Anxiety Scale (Corah’s Scale) and fear (KleinKnecht’s Scale) and were submitted to third molar extraction in two surgical times for the use of articaine or mepivacaine, both associated with adrenaline. The results were analyzed by ANOVA followed by Tukey post hoc test, Student's t test, and Pearson's correlation coefficients (α=0.05). </p> <p> <strong>Result</strong> There was no significant differences in saturation or heart rate. The blood pressure showed significant variations during time for both anesthetics, however mepivacaine resulted in a longer postoperative time to restore blood pressure. Patients with high or moderate anxiety and high fear index were those who had positive correlations with the highest blood pressure values. </p> <p> <strong>Conclusion</strong> Anxiety and fear positively influence the increase in blood pressure. Mepivacaine promoted a greater resistance to the return of normal vital signs, especially blood pressure levels. </p> <p><strong>Descriptors: </strong> Anxiety; fear; vital signs; blood pressure; local anesthetic</p> </div> <div class="articleSection articleSection--resumo" data-anchor="Resumo"> <h3 class="h5">Resumo</h3> <p> <strong>Introdução</strong> A ansiedade e a expectativa do paciente odontológico podem alterar de forma significativa seus sinais vitais. Da mesma forma, o uso de anestésico local associado a um vasoconstrictor também alteram os sinais vitais desses pacientes, promovendo alterações hemodinâmicas que podem resultar em situações de emergência. </p> <p> <strong>Objetivo</strong> Avaliar a influência da ansiedade de pacientes submetidos à exodontia de terceiros molares e do uso de diferentes substâncias anestésicas com adrenalina sobre seus sinais vitais (saturação de oxigênio, pulsação e pressão arterial sistólica e diastólica) em diferentes momentos operatórios. </p> <p> <strong>Material e método</strong> Quarenta pacientes responderam os questionários da Escala de Ansiedade Dentária (Escala de Corah) e de medo (Escala de Kleinknecht) e foram submetidos à exodontia dos terceiros molares em dois tempos cirúrgicos para utilização de articaína ou mepivacaína, ambos associados com adrenalina. Os resultados obtidos foram analisados por ANOVA seguido do teste post hoc de Tukey, t de Student e coeficientes de correlação de Pearson (α=0,05). </p> <p> <strong>Resultado</strong> Não houve alteração significativa na saturação nem na frequência cardíaca. A pressão arterial apresentou variações significantes nos tempos aferidos para os dois anestésicos, entretanto a mepivacaína resultou em maior tempo de pós-operatório para o restabelecimento da pressão arterial. Os pacientes com muita ou moderada ansiedade e alto índice de medo foram os que tiveram correlações positivas com os maiores números pressóricos aferidos. </p> <p> <strong>Conclusão</strong> A ansiedade e medo influenciam positivamente no aumento da pressão arterial. A mepivacaína promoveu uma maior resistência ao retorno da normalidade dos sinais vitais, especialmente dos níveis pressóricos. </p> <p><strong>Descritores: </strong> Ansiedade; medo; sinais vitais; pressão sanguínea; anestésico local</p> </div> <div class="articleSection" data-anchor="Text"> <h3 class="articleSectionTitle">INTRODUCTION</h3> <p>The basic monitoring of vital signs is commonly used in the practice of ambulatory care. Its use allows to obtain important information about the patient’s current state, such as blood pressure, heart rate, oxygen saturation and respiratory rate. These signs can be obtained in a non-invasive way through easily manipulated devices, sphygmomanometer and pulse oximeter. This practice has been increasingly used because of the growing number of high-risk patients in oral surgeries<span class="ref"><sup class="xref xrefblue"><a href="#B001_ref" data-ref="1 1 Arrigoni J, Lambrecht JT, Filippi A. Cardiovascular monitoring and its consequences in oral surgery. Schweiz Monatsschr Zahnmed. 2005;115(3):208-13. PMid:15832655.">1</a></sup></span>, mainly because many of them come to the clinic to undergo dental treatments without knowing if they have any type of systemic problem. The identification and control of these physiological indicators are some of the factors responsible for the promotion of successful treatments, avoiding emergencies that expose the patient to risky situations<span class="ref"><sup class="xref xrefblue"><a href="#B002_ref" data-ref="2 2 Costa RR, Silva PVR, Iwaki L Fo, Takeshita WM, Farah GJ. Avaliação da influência da expectativa e da ansiedade do paciente odontológico submetido a procedimento cirúrgico a partir de seus sinais vitais. Rev Odontol UNESP. 2012 Jan-Fev;41(1):43-7.">2</a></sup></span>. Therefore, monitoring has three major advantages: the ability to detect, evaluate and prevent emergencies in clinical practice.</p> <p>In dental surgical procedures, usually medium- or long-term local anesthetics are used to promote anesthesia during the transoperative period. Local anesthetics cause depression of the excitation of the nerve endings or inhibition of the conduction process in the peripheral nerves in a certain circumscribed area of the body<span class="ref"><sup class="xref xrefblue"><a href="#B003_ref" data-ref="3 3 Malamed SF. Manual de anestesia local. Rio de Janeiro: Guanabara Koogan; 2001.">3</a></sup></span>. In addition, anesthetic salts cause peripheral vasodilatation<span class="ref"><sup class="xref xrefblue"><a href="#B004_ref" data-ref="4 4 Palma FR, Lins LHS, Branco FP, Wygladala LG. Verificação da variação da pressão arterial pelo uso de anestésicos locais com vasoconstritor. Rev Odonto Ciência. 2005 Jan-Mar;20(47):35-9.">4</a></sup></span>, causing an increase in the blood volume in the site and consequently there is more bleeding during the surgical procedure. Therefore, the duration and effectiveness of the anesthetic become reduced. Among these anesthetic solutions, mepivacaine hydrochloride and articaine hydrochloride are the most commonly indicated for surgical procedures due to their longer duration.</p> <p>Mepivacaine, an amide group local anesthetic, has been used in dentistry since 1960. It is biotransformed in the liver and has a discrete vasodilator property, so its duration is 2 to 3 hours when associated with a vasoconstrictor. Its half-life is 1.9 hour with onset of action of 2 minutes. Articaine has been used as a local anesthetic in dentistry in Brazil since 1999. It also belongs to the amide group, but, unlike other anesthetics, it has a thiophene ring as a chemical chain radical, being the only local anesthetic of the amide group containing an ester group. Therefore, its biotransformation begins in blood plasma and tissues, and later part of it is metabolized in the liver, presenting a half-life of 27 minutes and low toxicity<span class="ref"><sup class="xref xrefblue"><a href="#B005_ref" data-ref="5 5 Schertzer ER Jr. Articaine vs. lidocaine. J Am Dent Assoc. 2000 Sep;131(9):1248-50.">5</a></sup></span>. Due to the presence of the thiophene ring, which gives it greater solubility, articaine exhibits high penetration and diffusion in the tissues, including bone tissue. Studies show that this anesthetic has a latency time of around 3 minutes and, when associated with adrenaline, duration of approximately 71 minutes<span class="ref"><sup class="xref xrefblue"><a href="#B004_ref" data-ref="4 4 Palma FR, Lins LHS, Branco FP, Wygladala LG. Verificação da variação da pressão arterial pelo uso de anestésicos locais com vasoconstritor. Rev Odonto Ciência. 2005 Jan-Mar;20(47):35-9.">4</a></sup></span><sup>,</sup><span class="ref"><sup class="xref xrefblue"><a href="#B006_ref" data-ref="6 6 Oertel R, Rahn R, Kirch W. Clinical pharmacohinetics of articaine. Clin Pharmacokinet. 1997 Dec;33(6):417-25. PMid:9435991. http://dx.doi.org/10.2165/00003088-199733060-00002. ">6</a></sup></span>.</p> <p>The association of vasoconstrictors with local anesthetics increases the anesthetic duration and effectiveness, and decreases its toxicity, since it becomes possible to use a lower volume of these solutions, in addition to the advantage of reducing local bleeding in the surgical procedure. However, the use of vasoconstrictors in dental practice is still an issue of high controversy because many dentists state that the use of substances such as adrenaline and noradrenaline cause significant hemodynamic changes, especially to blood pressure. In fact, the use of adrenaline in local anesthetics bears the risk of systemic absorption when used in large amounts, resulting in undesirable cardiovascular effects that can alter patients’ hemodynamics<span class="ref"><sup class="xref xrefblue"><a href="#B005_ref" data-ref="5 5 Schertzer ER Jr. Articaine vs. lidocaine. J Am Dent Assoc. 2000 Sep;131(9):1248-50.">5</a></sup></span>. On the other hand, several studies<span class="ref"><sup class="xref xrefblue"><a href="#B004_ref" data-ref="4 4 Palma FR, Lins LHS, Branco FP, Wygladala LG. Verificação da variação da pressão arterial pelo uso de anestésicos locais com vasoconstritor. Rev Odonto Ciência. 2005 Jan-Mar;20(47):35-9.">4</a></sup></span><sup>,</sup><span class="ref"><sup class="xref xrefblue"><a href="#B007_ref" data-ref="7 Tolas AG, Pflug AE, Halter JB. Arterial plasma epinephrine concentrations and hemodynamic responses after dental injection of local anesthetic with epinephrine. J Am Dent Assoc. 1982 Jan;104(1):41-3. PMid:6948029. http://dx.doi.org/10.14219/jada.archive.1982.0114. http://dx.doi.org/10.14219/jada.archive.... 8 Zottis D, Bernardes R, Wannmacher L. Efeito de vasoconstritor usado em anestesia local sobre a PA sistêmica e FC durante o atendimento odontológico. Rev ABO Nac. 1999;7:289-93.">7</a></sup></span><sup>-</sup><span class="ref"><sup class="xref xrefblue"><a href="#B009_ref" data-ref="9 9 Dantas MVM, Gabrielli MAC, Hochuli-Vieira E. Efeito da mepivacaínia 2% com adrenalina 1:100.000 sobre a pressão arterial. Rev Odontol UNESP. 2008;37(3):223-7.">9</a></sup></span> show that the amount of vasoconstrictors present in the local anesthetic is insufficient to cause any significant alteration. Mepivacaine and articaine, when associated with adrenaline 1:100,000 or 1:200,000 and administered in therapeutic doses, often do not promote major changes to blood pressure, heart rate, respiratory rate and oxygen saturation<span class="ref"><sup class="xref xrefblue"><a href="#B004_ref" data-ref="4 4 Palma FR, Lins LHS, Branco FP, Wygladala LG. Verificação da variação da pressão arterial pelo uso de anestésicos locais com vasoconstritor. Rev Odonto Ciência. 2005 Jan-Mar;20(47):35-9.">4</a></sup></span><sup>,</sup><span class="ref"><sup class="xref xrefblue"><a href="#B007_ref" data-ref="7 Tolas AG, Pflug AE, Halter JB. Arterial plasma epinephrine concentrations and hemodynamic responses after dental injection of local anesthetic with epinephrine. J Am Dent Assoc. 1982 Jan;104(1):41-3. PMid:6948029. http://dx.doi.org/10.14219/jada.archive.1982.0114. http://dx.doi.org/10.14219/jada.archive.... 8 Zottis D, Bernardes R, Wannmacher L. Efeito de vasoconstritor usado em anestesia local sobre a PA sistêmica e FC durante o atendimento odontológico. Rev ABO Nac. 1999;7:289-93.">7</a></sup></span><sup>-</sup><span class="ref"><sup class="xref xrefblue"><a href="#B009_ref" data-ref="9 9 Dantas MVM, Gabrielli MAC, Hochuli-Vieira E. Efeito da mepivacaínia 2% com adrenalina 1:100.000 sobre a pressão arterial. Rev Odontol UNESP. 2008;37(3):223-7.">9</a></sup></span>.</p> <p>The substances used in anesthesia are not the only ones capable of promoting hemodynamic changes<span class="ref"><sup class="xref xrefblue"><a href="#B010_ref" data-ref="10 10 Alemany-Martínez A, Valmaseda-Castellón E, Berini-Aytés L, Gay-Escoda C. Hemodynamic changes during the surgical removal of lower third molars. J Oral Maxillofac Surg. 2008 Mar;66(3):453-61. PMid:18280377. http://dx.doi.org/10.1016/j.joms.2007.06.634. ">10</a></sup></span>. Factors inherent to the patient can also trigger fear and decrease the pain threshold<span class="ref"><sup class="xref xrefblue"><a href="#B010_ref" data-ref="10 10 Alemany-Martínez A, Valmaseda-Castellón E, Berini-Aytés L, Gay-Escoda C. Hemodynamic changes during the surgical removal of lower third molars. J Oral Maxillofac Surg. 2008 Mar;66(3):453-61. PMid:18280377. http://dx.doi.org/10.1016/j.joms.2007.06.634. ">10</a></sup></span>. Since the patient is frequently in a state of anxiety and fear during the procedure, these emotional issues can imply changes to vital signs and in turn cause transoperative and postoperative complications. In 2001, Malamed<span class="ref"><sup class="xref xrefblue"><a href="#B003_ref" data-ref="3 3 Malamed SF. Manual de anestesia local. Rio de Janeiro: Guanabara Koogan; 2001.">3</a></sup></span> described that the stress to the patient caused by minor oral surgeries causes endogenous catecholamines (adrenaline and noradrenaline) to be released from their original site in an amount 40 times greater than the adrenaline present in the local anesthetic tube. In 2012, Costa et al.<span class="ref"><sup class="xref xrefblue"><a href="#B002_ref" data-ref="2 2 Costa RR, Silva PVR, Iwaki L Fo, Takeshita WM, Farah GJ. Avaliação da influência da expectativa e da ansiedade do paciente odontológico submetido a procedimento cirúrgico a partir de seus sinais vitais. Rev Odontol UNESP. 2012 Jan-Fev;41(1):43-7.">2</a></sup></span> showed in their study that the patient’s discomfort during the surgical procedure reflects on behavioral and physiological changes, which are extremely important, as they promote significant changes to the patient’s vital signs. In 2002, Chaia et al.<span class="ref"><sup class="xref xrefblue"><a href="#B011_ref" data-ref="11 11 Chaia A, Mandarino SCA, Gandelmann JH, Cavalcante MA, Alencastro VC. Análise da média aritmética da pressão arterial, frequência cardíaca e saturação de oxigênio durante as cirurgias de terceiros molares inclusos sob anestesia local e sedação prévia. Rev Bras Implant. 2002;8(4):29-31.">11</a></sup></span> analyzed that the expectation and fear can promote changes to blood pressure and cause tachycardia. In addition to these variations, altered emotional state can lead to a reduction in pain tolerance, raising the level of anxiety, thus establishing a vicious circle where local anesthetic agents could not act efficiently because they do not interfere directly with anxiety and stress<span class="ref"><sup class="xref xrefblue"><a href="#B012_ref" data-ref="12 12 Meyer FU. Haemodynamic changes under emotional stress following a minor surgical procedure under local anaesthesia. Int J Oral Maxillofac Surg. 1987 Dec;16(6):688-94. PMid:3125267. http://dx.doi.org/10.1016/S0901-5027(87)80054-1. ">12</a></sup></span>. Thus, ensuring the patient's comfort and safety so he/she is in a less apprehensive state is more effective to decrease the possible hemodynamic variations throughout the surgical procedure than avoiding the use of vasoconstrictors, since stress is also generated by the pain of an inadequate anesthesia.</p> <p>Considering that the great majority of patients who arrive at the dental office have some type of fear or anxiety about dental treatments, Corah et al.<span class="ref"><sup class="xref xrefblue"><a href="#B013_ref" data-ref="13 13 Corah NL, Gale EN, Illig SJ. Assessment of a dental anxiety scale. J Am Dent Assoc. 1978 Nov;97(5):816-9.">13</a></sup></span> in 1978 developed a questionnaire containing only four questions to rate the patients’ level of anxiety, thus allowing the dentist to prepare himself/herself to deal with certain types of patients. Similarly, in 1978, Kleinknecht, Bernstein<span class="ref"><sup class="xref xrefblue"><a href="#B014_ref" data-ref="14 14 Kleinknecht RA, Bernstein DA. The assessment of dental fear. Behav Ther. 1978 Sep;9(4):626-34. http://dx.doi.org/10.1016/S0005-7894(78)80138-5. ">14</a></sup></span> developed a questionnaire simulating various situations in the daily routine of a dental appointment, from the time of scheduling to the anesthesia, in order to rate the level of fear felt by the patient in certain situations, allowing the dentist to know in advance when his/her patient will require special attention.</p> <p>Considering the information above, this study evaluated the possible changes to vital signs (systolic and diastolic blood pressure [SBP and DBP}, heart rate and oxygen saturation) that occurred during the surgical extraction of included third molars, under local anesthesia, using vasoconstrictor (mepivacaine and articaine associated with adrenaline). Furthermore, the degree of anxiety and fear and their possible relation with the changes to vital signs, as part of changes to hemodynamics, were also evaluated.</p> <h3 class="articleSectionTitle">MATERIAL AND METHOD</h3> <h4>Sample Selection</h4> <p>This prospective study was conducted with patients who underwent surgical procedures, under local anesthesia, for extraction of included third molars. These patients were treated in “Oral and Maxillofacial Surgery and Traumatology” clinic of the Araraquara School of Dentistry - UNESP, and were operated by a single experienced surgeon.</p> <p>For this study, 40 healthy ASA I and II patients (American Society of Anesthesiologists, physical status 1), of both genders, aged 18-45 years, who had the four third molars indicated for extraction, and mandatorily followed these exclusion criteria, were selected: smoker; presence of infection sites involving third molars; presence of uncontrolled systemic diseases or psychiatric problems that can counter indicate the surgical procedure or interfere with the methodology; history of radiation in the head and neck region or use of chemotherapy; patients on chronic use of corticosteroids; female patients in menopause; pregnant patients; patients with cardiac alterations using (or not) medications; patients allergic to the study anesthetics; patients with systemic alterations or using medications that change bone repair; and immunosuppressed patients.</p> <p>All patients included in this study signed the informed consent form. In addition, we submitted the research work to the approval by the Ethics Committee on Human Research (CAAE: 30245314.0.0000.5416).</p> <h4>Preoperative Evaluation</h4> <p>We used a standardized health form of the “Oral and Maxillofacial Surgery and Traumatology” clinic of the Araraquara School of Dentistry to perform the anamnesis and clinical exam of the patients. Imaging evaluation was performed with panoramic radiographs to surgical planning and the type of impaction of the third molar was not considered for patient inclusion (or not) in this study.</p> <h4>Experimental Groups</h4> <p>The forty patients were divided into two groups, according to the type of local anesthetic used:</p> <p>Group M (n=20): Patients submitted to surgery using local anesthetic containing mepivacaine hydrochloride 2% (36mg) with epinephrine 1:100,000 (18μg)/1.8ml tube (DFL-Rio de Janeiro-RJ).</p> <p>Group A (n=20): Patients submitted to surgery using local anesthetic containing articaine hydrochloride 4% (72mg) with epinephrine 1:100,000 (18μg)/1.8ml tube (DFL-Rio de Janeiro-RJ).</p> <h4>Pre-surgical Procedures</h4> <p>Prior to the surgical procedure, in a quiet room separated from the surgical center, and after the patient was seated in the room for about 5 minutes, the vital signs were checked and noted on a standardized form. Afterwards, the patient completed a Corah’s Scale<span class="ref"><sup class="xref xrefblue"><a href="#B013_ref" data-ref="13 13 Corah NL, Gale EN, Illig SJ. Assessment of a dental anxiety scale. J Am Dent Assoc. 1978 Nov;97(5):816-9.">13</a></sup></span> and Kleinknecht’s Scale form<span class="ref"><sup class="xref xrefblue"><a href="#B014_ref" data-ref="14 14 Kleinknecht RA, Bernstein DA. The assessment of dental fear. Behav Ther. 1978 Sep;9(4):626-34. http://dx.doi.org/10.1016/S0005-7894(78)80138-5. ">14</a></sup></span>.</p> <p>In addition, at that time, each patient received 1g of amoxicillin, 500mg of sodium dipyrone and 20mg of omeprazole. Patients allergic to penicillin received 600mg of clindamycin, and those allergic to dipyrone received 750mg of paracetamol.</p> <h4>Vital Signs</h4> <p>We noted the values of vital signs of blood pressure (BP) expressed in millimeters of mercury (mmHg), heart rate (HR) expressed in beats per minute (bpm), respiratory rate (RR) expressed in breaths per minute (bpm) and oxygen saturation (SaO<sup>2</sup>) expressed in percentage (%), using the digital monitor FOXIMETER (MD 300C21): at 5 different time points:</p> <ul style="list-style-type: none" id="L1" type="1"> <li> <p>T<sub>0</sub>: Before the beginning of the procedure and outside the surgical environment</p> </li> <li> <p>T<sub>1</sub>: Five minutes after the end of local anesthetic application</p> </li> <li> <p>T<sub>2</sub>: Halfway through the surgical procedure</p> </li> <li> <p>T<sub>3</sub>: Immediately after the end of surgery and</p> </li> <li> <p>T<sub>4</sub>: Fifteen minutes after the end of surgery</p> </li> </ul> <p>All values obtained were recorded in tables and the data inserted in spreadsheets for analysis. A single trained and calibrated examiner recorded the vital signs.</p> <h4>Anxiety and Fear Scales</h4> <p>Prior to the surgical procedure, we instructed each patient to complete two anxiety and fear assessment forms, described below:</p> <ul style="list-style-type: none" id="L2" type="1"> <li> <p>1 - Corah’s Dental Anxiety Scale (DAS)<span class="ref"><sup class="xref xrefblue"><a href="#B013_ref" data-ref="13 13 Corah NL, Gale EN, Illig SJ. Assessment of a dental anxiety scale. J Am Dent Assoc. 1978 Nov;97(5):816-9.">13</a></sup></span> - Corah’s scale of anxiety for dental treatment [the peak was 15, and over 12 was considered intense anxiety]. The scale is composed of three questions. Each question has five alternatives: a (value 1), b (value 2), c (value 3), d (value 4), and e (value 5).</p> </li> <li> <p>2 - Kleinknecht's Dental Fear Scale (DFS)<span class="ref"><sup class="xref xrefblue"><a href="#B014_ref" data-ref="14 14 Kleinknecht RA, Bernstein DA. The assessment of dental fear. Behav Ther. 1978 Sep;9(4):626-34. http://dx.doi.org/10.1016/S0005-7894(78)80138-5. ">14</a></sup></span> - Kleinknecht’s Scale for the evaluation of fear of dental treatment [composed of six different situations with 20 alternatives].</p> </li> </ul> <h4>Pain Scale</h4> <p>We used the visual analog scale, ranging from 0 (no pain) to 10 (intense pain) to obtain the pain intensity in the transoperative period (completed by the patient at the end of the surgical) and postoperative period.</p> <h4>Surgical Procedures</h4> <p>In the first surgical time point, we removed the lower and upper third molars from one of the sides of the jaws, randomly chosen (e.g. teeth 18 and 48 or 28 and 38). Likewise, we randomly selected the anesthetic for the procedure of the first surgical time point. The surgery side and anesthetic type were randomly selected to ensure an unbiased representation for each experimental group, not compromising the results (for example, the side where the anesthetic was more easily applied could be favored and the side where the teeth were greatly impacted could be disfavored).</p> <p>The second surgical time point, performed three weeks after the first one, started in the same way previously described, that is, measuring vital signs and giving medications. Then, we removed the other two (upper and lower) third molars, using a different anesthetic from the one used in the first time point, in order to guarantee that both anesthetic solutions were used in the same patient.</p> <p>We noted the duration of surgical procedures as well as the number of anesthetic tubes used for each patient from groups M and A.</p> <p>In each surgical time point, we prescribed in the postoperative period: amoxicillin or clindamycin; sodium dipyrone or paracetamol; nimesulide and omeprazole (orally) and chlorhexidine for use in mouthwashes.</p> <h4>Statistical Analyses</h4> <p>For the data correlated with the changes to physiological signs as for the type of anesthetic used and pain sensitivity, we applied ANOVA followed by Tukey post hoc test (α=0.05). To evaluate the results obtained for anxiety, we applied the Student's statistical t-test and Pearson's correlation coefficients (α=0.05).</p> <h3 class="articleSectionTitle">RESULT</h3> <p>In this study, the mean age of the patients was 22.4 years, with minimum age of 18 years and maximum age of 30 years. The population consisted of 26 women (65%) and 14 men (35%).</p> <p><a href="" class="open-asset-modal" data-bs-toggle="modal" data-bs-target="#ModalTablet01"><span class="sci-ico-fileTable"></span>Tables 1</a> and <a href="" class="open-asset-modal" data-bs-toggle="modal" data-bs-target="#ModalTablet02"><span class="sci-ico-fileTable"></span>2</a> show the means and standard deviations for the physiological indicators: systolic and diastolic blood pressure, oxygen saturation and heart rate, recorded at five different time points from preoperative to postoperative period for patients submitted to third molar extraction and anesthetized, respectively, with articaine 4% associated with adrenaline (1:100,000) and mepivacaine 2% associated with adrenaline (1:100,000).</p> <div class="row table" id="t01"> <a name="t01"></a><div class="col-md-4 col-sm-4"><a data-bs-toggle="modal" data-bs-target="#ModalTablet01"><div class="thumbOff"> Thumbnail <div class="zoom"><span class="sci-ico-zoom"></span></div> </div></a></div> <div class="col-md-8 col-sm-8"> <strong><strong>Table 1</strong></strong><br> Means (standard deviations) of physiological indicators monitored in subjects under anesthesia with articaine, according to the 5 monitoring periods <br> </div> </div> <div class="row table" id="t02"> <a name="t02"></a><div class="col-md-4 col-sm-4"><a data-bs-toggle="modal" data-bs-target="#ModalTablet02"><div class="thumbOff"> Thumbnail <div class="zoom"><span class="sci-ico-zoom"></span></div> </div></a></div> <div class="col-md-8 col-sm-8"> <strong><strong>Table 2</strong></strong><br> Means (standard deviations) of physiological indicators monitored in subjects under anesthesia with mepivacaine, according to the 5 monitoring periods <br> </div> </div> <p>From the tables we can observe that there were changes to the vital signs during the surgical procedure for both anesthetics. Oxygen saturation was the only physiological indicator to remain stable during all recorded time points, with no significant variations for the results. We observed that the changes to heart rate and blood pressure were similar, and at the time point T<sub>1</sub> both of them increased significantly and remained at this level until halfway through the surgical procedure. At the time point T<sub>4</sub> the values returned to the initial value. The return of the indicators to the initial level was more effective when using articaine, occurring at the end of the surgical procedure, while for mepivacaine it took fifteen minutes after surgery.</p> <p>The analyses of variance found no differences between means of saturation during monitoring (p=0.388 for articaine and p=0.143 for mepivacaine). In all other cases there was evidence of a significant variation of the means during monitoring (p<0.05). The Tukey test was applied to explain these variations of means of physiological indicators and the results are summarized in <a href="" class="open-asset-modal" data-bs-toggle="modal" data-bs-target="#ModalTablet01"><span class="sci-ico-fileTable"></span>Tables 1</a> and <a href="" class="open-asset-modal" data-bs-toggle="modal" data-bs-target="#ModalTablet02"><span class="sci-ico-fileTable"></span>2</a>.</p> <p><a href="" class="open-asset-modal" data-bs-toggle="modal" data-bs-target="#ModalTablet03"><span class="sci-ico-fileTable"></span>Table 3</a> shows the means and standard deviations of pain intensity monitored at certain postoperative time points for both anesthetic solutions used in this study. The analyses of variance revealed differences between means in the monitoring period of pain (p<0.05). The results of the Tukey test are summarized in <a href="" class="open-asset-modal" data-bs-toggle="modal" data-bs-target="#ModalTablet03"><span class="sci-ico-fileTable"></span>Table 3</a>. We observed that the means of pain intensity experienced by the patients were higher in the first 12 postoperative hours and decreased progressively up to 36 postoperative hours, remaining at this level in the next evaluation, after 48 hours. However, throughout the monitoring period, the intensity of pain after surgical intervention with articaine always remained below the levels following intervention with mepivacaine.</p> <div class="row table" id="t03"> <a name="t03"></a><div class="col-md-4 col-sm-4"><a data-bs-toggle="modal" data-bs-target="#ModalTablet03"><div class="thumbOff"> Thumbnail <div class="zoom"><span class="sci-ico-zoom"></span></div> </div></a></div> <div class="col-md-8 col-sm-8"> <strong><strong>Table 3</strong></strong><br> Intensity of pain at the specified time points following the surgical procedure <br> </div> </div> <p>Regarding the emotional factor, <a href="" class="open-asset-modal" data-bs-toggle="modal" data-bs-target="#ModalFiggf01"><span class="sci-ico-fileFigure"></span>Figure 1</a> shows the percentages in each category of level of fear experienced by the 40 patients in certain situations, according to the questions proposed by Kleinknecht, Bernstein<span class="ref"><sup class="xref xrefblue"><a href="#B014_ref" data-ref="14 14 Kleinknecht RA, Bernstein DA. The assessment of dental fear. Behav Ther. 1978 Sep;9(4):626-34. http://dx.doi.org/10.1016/S0005-7894(78)80138-5. ">14</a></sup></span>. We observed that 20% of the patients reported they always felt tense during the consultation with the dentist. No patient reported to experience nausea (100%) during consultations. In addition, the patients reported to have more fear in the following time points: when he/she sees and feels the anesthesia needle and when he/she hears and feels the motor.</p> <div class="row fig" id="gf01"> <a name="gf01"></a><div class="col-md-4 col-sm-4"><a data-bs-toggle="modal" data-bs-target="#ModalFiggf01"><div class="thumbImg"> <img src="https://minio.scielo.br/documentstore/1807-2577/tjKGtmnFK4ZJmbYBctVvddh/d5158f5a217fae0aa44c7b488fa8c977bd77d774.jpg"><div class="zoom"><span class="sci-ico-zoom"></span></div> </div></a></div> <div class="col-md-8 col-sm-8"> <strong><strong>Figure 1</strong></strong><br> Percentages of responses to the Kleinknecht’s scale<span class="ref"><sup class="xref xrefblue"><a href="#B014_ref" data-ref="14 14 Kleinknecht RA, Bernstein DA. The assessment of dental fear. Behav Ther. 1978 Sep;9(4):626-34. http://dx.doi.org/10.1016/S0005-7894(78)80138-5. ">14</a></sup></span> scores. <br> </div> </div> <p>In the evaluation of the anxiety index through the Corah’s Scale<span class="ref"><sup class="xref xrefblue"><a href="#B013_ref" data-ref="13 13 Corah NL, Gale EN, Illig SJ. Assessment of a dental anxiety scale. J Am Dent Assoc. 1978 Nov;97(5):816-9.">13</a></sup></span>, we obtained the means of 10.1 (standard deviation 3.5) for females and 9.5 (standard deviation 9.5) for males. The patients could be rated into four levels of anxiety according to the score obtained by the scale: <9 for low anxious patients; 9-12 for moderately anxious patients; 13-14 for very anxious patients; and >15 for severely anxious patients. Both men and women participating in the study were classifed as moderately anxious. No significant difference was observed between genders for the means of anxiety (Student's t-test - p=0.800). We also observed no significant correlation between the anxiety rates and any of the variables studied, for neither articaine nor mepivacaine. Pearson's correlation coefficients ranged from -0.219 to 0.355, all of which were not significantly different from zero (p>0.05).</p> <h3 class="articleSectionTitle">DISCUSSION</h3> <p>Surgery for the extraction of third molars is one of the most common occurrences among all surgical procedures and, mainly, under local anesthesia. This study evaluated the possible changes to vital signs that occurred during this surgical procedure using two local anesthetics with vasoconstrictor. Furthermore, the degree of anxiety and fear and their possible relation with the changes to vital signs, as part of changes to hemodynamics, were also evaluated.</p> <p>The population of this study was composed of young people who are the age group who most seek this type of surgical procedure. This confirms the research potential, which was performed with patients (exclusively ASA I) under 40 years of age who did not present any type of health impairment or use medications routinely. These data, as described above, support the data reported in other studies in the literature, including a larger proportion of female patients, reflecting the gender that most seeks treatment<span class="ref"><sup class="xref xrefblue"><a href="#B002_ref" data-ref="2 2 Costa RR, Silva PVR, Iwaki L Fo, Takeshita WM, Farah GJ. Avaliação da influência da expectativa e da ansiedade do paciente odontológico submetido a procedimento cirúrgico a partir de seus sinais vitais. Rev Odontol UNESP. 2012 Jan-Fev;41(1):43-7.">2</a></sup></span><sup>,</sup><span class="ref"><sup class="xref xrefblue"><a href="#B015_ref" data-ref="15 15 Sirin Y, Humphris G, Sencan S, Firat D. What is the most fearful intervention in ambulatory oral surgery? Analysis of an outpatient clinic. Int J Oral Maxillofac Surg. 2012 Oct;41(10):1284-90. PMid:22832662. http://dx.doi.org/10.1016/j.ijom.2012.06.013. ">15</a></sup></span><sup>,</sup><span class="ref"><sup class="xref xrefblue"><a href="#B016_ref" data-ref="16 16 Aznar-Arasa L, Figueiredo R, Valmaseda-Castellón E, Gay-Escoda C. Patient anxiety and surgical difficulty in impacted lower third molar extractions: a prospective cohort study. Int J Oral Maxillofac Surg. 2014 Sep;43(9):1131-6. PMid:24837553. http://dx.doi.org/10.1016/j.ijom.2014.04.005. ">16</a></sup></span>.</p> <p>Adrenaline is the most used vasoconstrictor in dentistry, being an important additive in local anesthetic solutions, mainly for use in surgical procedures. The major advantages of using adrenaline are slowing the absorption rate and decreasing the systemic blood level of the anesthetic drug in addition to prolonging the duration of anesthesia. On the other hand, vasoconstrictors are not devoid of complications. Like the anesthetic substance, the vasoconstrictor is absorbed into the bloodstream and can reach levels that influence the hemodynamics of the heart and blood vessels. The increase in adrenaline plasma levels has a dose-dependent linear relationship and persists for hours<sup>3</sup>.</p> <p>The results showed that, generally, the highest increase in blood pressure, especially SBP, occurred within five minutes of infiltration of the anesthetic substance (T<sub>1</sub>), when using both articaine and mepivacaine associated with adrenaline. Cardiac hemodynamics seems to be affected early in the beginning of the vasoconstrictor absorption. A previous study by Brkovic et al.<span class="ref"><sup class="xref xrefblue"><a href="#B017_ref" data-ref="17 17 Brkovic B, Gardasevic M, Roganovic J, Jovic N, Todorovic L, Stojic D. Lidocaine+clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects. Int J Oral Maxillofac Surg. 2008 Feb;37(2):149-55. PMid:17822879. http://dx.doi.org/10.1016/j.ijom.2007.07.019. ">17</a></sup></span>, using lidocaine associated with adrenaline, observed that ten minutes (on average) following the application of the anesthesia there was an increase in the heart rate and pressure values and these are maintained on a prolonged basis. In fact, in our sample, this increase, mainly in blood pressure, was observed and maintained until halfway through the surgical procedure (T<sub>2</sub>). In all treated patients, the surgeon initiated the surgical procedure by removing the upper third molar and ended by removing the lower third molar, on the treated side at each surgical time point. In all patients of this sample, for the removal of the upper third molar, we used, on average, one and a half tubes of mepivacaine 2% with epinephrine 1:100,000 or articaine 4% with epinephrine 1:100,000. Therefore, we injected the same amount of vasoconstrictor as the different anesthetic solutions, that is, on average, 0.030mg of adrenaline. The same increased measure of blood pressure was maintained until the T<sub>2</sub> period, corresponding to half the time of the surgical procedure for the extraction of the upper and lower third molars on one side of the jaws. This means that at T<sub>2</sub> the anesthesia for the removal of the lower tooth was already performed and, on average, another two and a half tubes of anesthetic solution were used, adding more 0.050mg of adrenaline. Despite the addition of a greater amount of adrenaline, it did not cause an even greater increase in systolic or diastolic pressure, as we can see from the results described in <a href="" class="open-asset-modal" data-bs-toggle="modal" data-bs-target="#ModalTablet01"><span class="sci-ico-fileTable"></span>Tables 1</a> and <a href="" class="open-asset-modal" data-bs-toggle="modal" data-bs-target="#ModalTablet02"><span class="sci-ico-fileTable"></span>2</a>. In addition, we must take into account that the endogenous catecholamines corresponding to the stress of the surgical procedure are released.</p> <p>Absorption of adrenaline into the bloodstream results in some cardiac hemodynamic change related to both heart rate and blood pressure. Despite these changes, in healthy patients, it is not enough to exhibit a clinically significant effect<span class="ref"><sup class="xref xrefblue"><a href="#B018_ref" data-ref="18 18 Salonen M, Forssell H, Scheinin M. Local dental anaesthesia with lidocaine and adrenaline. Effects on plasma cathecolamines, heart rate and blood pressure. Int J Oral Maxillofac Surg. 1988 Dec;17(6):392-4. PMid:3145958. http://dx.doi.org/10.1016/S0901-5027(88)80071-7. ">18</a></sup></span>. Although increased heart rate and blood pressure were observed in all patients in the sample, none of them showed symptoms that clinically revealed the changes in these parameters.</p> <p>When analyzing the values found in <a href="" class="open-asset-modal" data-bs-toggle="modal" data-bs-target="#ModalTablet01"><span class="sci-ico-fileTable"></span>Tables 1</a> and <a href="" class="open-asset-modal" data-bs-toggle="modal" data-bs-target="#ModalTablet02"><span class="sci-ico-fileTable"></span>2</a> it is possible to observe that both anesthetics caused an increase in blood pressure that was almost reestablished at the end of the procedure. Of the 40 patients evaluated, with the use of articaine, 10 patients had systolic blood pressure between 130 and 145 and diastolic blood pressure of 90 to 111.5. When using mepivacaine, 11 patients had blood pressure change (values mentioned above). However, by using mepivacaine, the blood pressure levels remained longer with a high blood pressure pattern and required a longer rest period to match the initial value. Possibly, this fact is due to the vasodilation power of the anesthetic substance. In this case, the vasodilation capacity of mepivacaine is considered lower than that of articaine, allowing the associated vasoconstrictor to be partially inhibited according to the vasodilatory power of the anesthetic substance. In addition, it is possible that articaine had less prolonged effect on cardiac changes.</p> <p>Articaine is an anesthetic considered highly diffusible in both soft tissues and bone tissue. Due to its high diffusibility, it is also probably responsible for the result observed, i.e., that, on average, the patients reported less immediate postoperative pain. However, this capacity cannot be related to the fact that in later postoperative times the same result has occurred. Perhaps the explanation for the lower degree of pain demonstrated in the postoperative period of more than 12 hours is that the patient experienced less initial pain and, therefore, presented less postoperative stress and, consequently, it influenced the pain threshold, providing articaine with higher effectiveness. The transoperative difficulties must also be considered as the result of greater intensity and duration of pain. In this sense, we can consider the anatomical difficulties, such as the need for bone removal or odontosection, which make dental extraction and postoperative period more complex<span class="ref"><sup class="xref xrefblue"><a href="#B016_ref" data-ref="16 16 Aznar-Arasa L, Figueiredo R, Valmaseda-Castellón E, Gay-Escoda C. Patient anxiety and surgical difficulty in impacted lower third molar extractions: a prospective cohort study. Int J Oral Maxillofac Surg. 2014 Sep;43(9):1131-6. PMid:24837553. http://dx.doi.org/10.1016/j.ijom.2014.04.005. ">16</a></sup></span>.</p> <p>For patients who, at the end of the surgery, remained with high systolic and diastolic pressure, we observed that coincidentally they are the same subjects who (when using mepivacaine) took a longer time from the end of surgery until blood pressure was normalized. For these patients the Corah’s<span class="ref"><sup class="xref xrefblue"><a href="#B013_ref" data-ref="13 13 Corah NL, Gale EN, Illig SJ. Assessment of a dental anxiety scale. J Am Dent Assoc. 1978 Nov;97(5):816-9.">13</a></sup></span> and Kleinknecht’s<span class="ref"><sup class="xref xrefblue"><a href="#B014_ref" data-ref="14 14 Kleinknecht RA, Bernstein DA. The assessment of dental fear. Behav Ther. 1978 Sep;9(4):626-34. http://dx.doi.org/10.1016/S0005-7894(78)80138-5. ">14</a></sup></span> scales show that they can be classified as anxious or highly anxious and apprehensive people, with a high degree of fear of the proposed treatment. Of the 11 patients previously mentioned who presented a more significant pressure change, 7 were classified as anxious and only 1 as extremely anxious. These data are the same as those found in the studies by Costa et al.<span class="ref"><sup class="xref xrefblue"><a href="#B002_ref" data-ref="2 2 Costa RR, Silva PVR, Iwaki L Fo, Takeshita WM, Farah GJ. Avaliação da influência da expectativa e da ansiedade do paciente odontológico submetido a procedimento cirúrgico a partir de seus sinais vitais. Rev Odontol UNESP. 2012 Jan-Fev;41(1):43-7.">2</a></sup></span> and Maggirias, Locker<span class="ref"><sup class="xref xrefblue"><a href="#B019_ref" data-ref="19 19 Maggirias J, Locker D. Five-year incidence of dental anxiety in an adult population. Community Dent Health. 2002 Sep;19(3):173-9. PMid:12269464.">19</a></sup></span>. On the Kleinknecht’s scale<span class="ref"><sup class="xref xrefblue"><a href="#B014_ref" data-ref="14 14 Kleinknecht RA, Bernstein DA. The assessment of dental fear. Behav Ther. 1978 Sep;9(4):626-34. http://dx.doi.org/10.1016/S0005-7894(78)80138-5. ">14</a></sup></span>, 15 patients with high fear, 1 patient with very high fear and 1 patient with phobia (extreme fear) were found, making up a total of 30% of moderately to very anxious patients and 50% classified as fearing the procedure. In addition, the presence of anxiety and fear may have contributed to the increase in blood pressure. This becomes clear in cases in which the initial pressure values were already changed.</p> <p>The idea of surgical procedure undoubtedly causes more anxiety than any other type of dental care<span class="ref"><sup class="xref xrefblue"><a href="#B015_ref" data-ref="15 15 Sirin Y, Humphris G, Sencan S, Firat D. What is the most fearful intervention in ambulatory oral surgery? Analysis of an outpatient clinic. Int J Oral Maxillofac Surg. 2012 Oct;41(10):1284-90. PMid:22832662. http://dx.doi.org/10.1016/j.ijom.2012.06.013. ">15</a></sup></span>. Eli et al.<span class="ref"><sup class="xref xrefblue"><a href="#B020_ref" data-ref="20 20 Eli I, Schwartz-Arad D, Baht R, Ben-Tuvim H. Effect of anxiety on the experience of pain in implant insertion. Clin Oral Implants Res. 2003 Feb;14(1):115-8. PMid:12562373. http://dx.doi.org/10.1034/j.1600-0501.2003.140115.x. ">20</a></sup></span>, who evaluated the relationship of anxiety and pain during and after the installation of dental implants, observed that women had higher relation of high anxiety levels with pain than men. In our study, the same correlation cannot be made because the number of female patients in the sample was higher (65% females/35% males). Even so, we observed a higher correlation between postoperative exacerbated pain and anxiety in female patients than in male patients.</p> <h3 class="articleSectionTitle">CONCLUSION</h3> <p>According to the information above, we can conclude that:</p> <ol id="L3" type="1"> <li> <sup><strong>1</strong></sup> <p>The presence of anxiety and fear positively influenced the increase in blood pressure;</p> </li> <li> <sup><strong>2</strong></sup> <p>The need for diagnosis and anxiety control was evident in patients who will undergo surgical procedures in order to avoid or prevent risk situations;</p> </li> <li> <sup><strong>3</strong></sup> <p>Mepivacaine promoted a greater resistance to the return to normal vital signs, especially blood pressure levels.</p> </li> </ol> </div> <div class="articleSection" data-anchor="REFERENCES"> <h3 class="articleSectionTitle">REFERENCES</h3> <div class="row"><div class="col ref-list"><ul class="refList articleFootnotes"> <li> <a class="" name="B001_ref"></a><sup class="xref">1</sup> Arrigoni J, Lambrecht JT, Filippi A. Cardiovascular monitoring and its consequences in oral surgery. Schweiz Monatsschr Zahnmed. 2005;115(3):208-13. PMid:15832655.</li> <li> <a class="" name="B002_ref"></a><sup class="xref">2</sup> Costa RR, Silva PVR, Iwaki L Fo, Takeshita WM, Farah GJ. Avaliação da influência da expectativa e da ansiedade do paciente odontológico submetido a procedimento cirúrgico a partir de seus sinais vitais. Rev Odontol UNESP. 2012 Jan-Fev;41(1):43-7.</li> <li> <a class="" name="B003_ref"></a><sup class="xref">3</sup> Malamed SF. Manual de anestesia local. Rio de Janeiro: Guanabara Koogan; 2001.</li> <li> <a class="" name="B004_ref"></a><sup class="xref">4</sup> Palma FR, Lins LHS, Branco FP, Wygladala LG. Verificação da variação da pressão arterial pelo uso de anestésicos locais com vasoconstritor. Rev Odonto Ciência. 2005 Jan-Mar;20(47):35-9.</li> <li> <a class="" name="B005_ref"></a><sup class="xref">5</sup> Schertzer ER Jr. Articaine vs. lidocaine. J Am Dent Assoc. 2000 Sep;131(9):1248-50.</li> <li> <a class="" name="B006_ref"></a><sup class="xref">6</sup> Oertel R, Rahn R, Kirch W. Clinical pharmacohinetics of articaine. Clin Pharmacokinet. 1997 Dec;33(6):417-25. PMid:9435991. http://dx.doi.org/10.2165/00003088-199733060-00002 <br><a href="http://dx.doi.org/10.2165/00003088-199733060-00002" target="_blank">» http://dx.doi.org/10.2165/00003088-199733060-00002</a> </li> <li> <a class="" name="B007_ref"></a><sup class="xref">7</sup> Tolas AG, Pflug AE, Halter JB. Arterial plasma epinephrine concentrations and hemodynamic responses after dental injection of local anesthetic with epinephrine. J Am Dent Assoc. 1982 Jan;104(1):41-3. PMid:6948029. http://dx.doi.org/10.14219/jada.archive.1982.0114 <br><a href="http://dx.doi.org/10.14219/jada.archive.1982.0114" target="_blank">» http://dx.doi.org/10.14219/jada.archive.1982.0114</a> </li> <li> <a class="" name="B008_ref"></a><sup class="xref">8</sup> Zottis D, Bernardes R, Wannmacher L. Efeito de vasoconstritor usado em anestesia local sobre a PA sistêmica e FC durante o atendimento odontológico. Rev ABO Nac. 1999;7:289-93.</li> <li> <a class="" name="B009_ref"></a><sup class="xref">9</sup> Dantas MVM, Gabrielli MAC, Hochuli-Vieira E. Efeito da mepivacaínia 2% com adrenalina 1:100.000 sobre a pressão arterial. Rev Odontol UNESP. 2008;37(3):223-7.</li> <li> <a class="" name="B010_ref"></a><sup class="xref">10</sup> Alemany-Martínez A, Valmaseda-Castellón E, Berini-Aytés L, Gay-Escoda C. Hemodynamic changes during the surgical removal of lower third molars. J Oral Maxillofac Surg. 2008 Mar;66(3):453-61. PMid:18280377. http://dx.doi.org/10.1016/j.joms.2007.06.634 <br><a href="http://dx.doi.org/10.1016/j.joms.2007.06.634" target="_blank">» http://dx.doi.org/10.1016/j.joms.2007.06.634</a> </li> <li> <a class="" name="B011_ref"></a><sup class="xref">11</sup> Chaia A, Mandarino SCA, Gandelmann JH, Cavalcante MA, Alencastro VC. Análise da média aritmética da pressão arterial, frequência cardíaca e saturação de oxigênio durante as cirurgias de terceiros molares inclusos sob anestesia local e sedação prévia. Rev Bras Implant. 2002;8(4):29-31.</li> <li> <a class="" name="B012_ref"></a><sup class="xref">12</sup> Meyer FU. Haemodynamic changes under emotional stress following a minor surgical procedure under local anaesthesia. Int J Oral Maxillofac Surg. 1987 Dec;16(6):688-94. PMid:3125267. http://dx.doi.org/10.1016/S0901-5027(87)80054-1 <br><a href="http://dx.doi.org/10.1016/S0901-5027(87)80054-1" target="_blank">» http://dx.doi.org/10.1016/S0901-5027(87)80054-1</a> </li> <li> <a class="" name="B013_ref"></a><sup class="xref">13</sup> Corah NL, Gale EN, Illig SJ. Assessment of a dental anxiety scale. J Am Dent Assoc. 1978 Nov;97(5):816-9.</li> <li> <a class="" name="B014_ref"></a><sup class="xref">14</sup> Kleinknecht RA, Bernstein DA. The assessment of dental fear. Behav Ther. 1978 Sep;9(4):626-34. http://dx.doi.org/10.1016/S0005-7894(78)80138-5 <br><a href="http://dx.doi.org/10.1016/S0005-7894(78)80138-5" target="_blank">» http://dx.doi.org/10.1016/S0005-7894(78)80138-5</a> </li> <li> <a class="" name="B015_ref"></a><sup class="xref">15</sup> Sirin Y, Humphris G, Sencan S, Firat D. What is the most fearful intervention in ambulatory oral surgery? Analysis of an outpatient clinic. Int J Oral Maxillofac Surg. 2012 Oct;41(10):1284-90. PMid:22832662. http://dx.doi.org/10.1016/j.ijom.2012.06.013 <br><a href="http://dx.doi.org/10.1016/j.ijom.2012.06.013" target="_blank">» http://dx.doi.org/10.1016/j.ijom.2012.06.013</a> </li> <li> <a class="" name="B016_ref"></a><sup class="xref">16</sup> Aznar-Arasa L, Figueiredo R, Valmaseda-Castellón E, Gay-Escoda C. Patient anxiety and surgical difficulty in impacted lower third molar extractions: a prospective cohort study. Int J Oral Maxillofac Surg. 2014 Sep;43(9):1131-6. PMid:24837553. http://dx.doi.org/10.1016/j.ijom.2014.04.005 <br><a href="http://dx.doi.org/10.1016/j.ijom.2014.04.005" target="_blank">» http://dx.doi.org/10.1016/j.ijom.2014.04.005</a> </li> <li> <a class="" name="B017_ref"></a><sup class="xref">17</sup> Brkovic B, Gardasevic M, Roganovic J, Jovic N, Todorovic L, Stojic D. Lidocaine+clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects. Int J Oral Maxillofac Surg. 2008 Feb;37(2):149-55. PMid:17822879. http://dx.doi.org/10.1016/j.ijom.2007.07.019 <br><a href="http://dx.doi.org/10.1016/j.ijom.2007.07.019" target="_blank">» http://dx.doi.org/10.1016/j.ijom.2007.07.019</a> </li> <li> <a class="" name="B018_ref"></a><sup class="xref">18</sup> Salonen M, Forssell H, Scheinin M. Local dental anaesthesia with lidocaine and adrenaline. Effects on plasma cathecolamines, heart rate and blood pressure. Int J Oral Maxillofac Surg. 1988 Dec;17(6):392-4. PMid:3145958. http://dx.doi.org/10.1016/S0901-5027(88)80071-7 <br><a href="http://dx.doi.org/10.1016/S0901-5027(88)80071-7" target="_blank">» http://dx.doi.org/10.1016/S0901-5027(88)80071-7</a> </li> <li> <a class="" name="B019_ref"></a><sup class="xref">19</sup> Maggirias J, Locker D. Five-year incidence of dental anxiety in an adult population. Community Dent Health. 2002 Sep;19(3):173-9. PMid:12269464.</li> <li> <a class="" name="B020_ref"></a><sup class="xref">20</sup> Eli I, Schwartz-Arad D, Baht R, Ben-Tuvim H. Effect of anxiety on the experience of pain in implant insertion. Clin Oral Implants Res. 2003 Feb;14(1):115-8. PMid:12562373. http://dx.doi.org/10.1034/j.1600-0501.2003.140115.x <br><a href="http://dx.doi.org/10.1034/j.1600-0501.2003.140115.x" target="_blank">» http://dx.doi.org/10.1034/j.1600-0501.2003.140115.x</a> </li> </ul></div></div> </div> <div class="articleSection" data-anchor="Publication Dates"> <h3 class="articleSectionTitle">Publication Dates</h3> <div class="row"><div class="col-md-12 col-sm-12"><ul class="articleTimeline"><li> <strong>Publication in this collection</strong><br>Oct 2017</li></ul></div></div> </div> <div class="articleSection" data-anchor="History"> <h3 class="articleSectionTitle">History</h3> <div class="row"><div class="col-md-12 col-sm-12"><ul class="articleTimeline"> <li> <strong>Received</strong><br>10 Apr 2017</li> <li> <strong>Accepted</strong><br>30 Aug 2017</li> </ul></div></div> </div> <section class="documentLicense"><div class="container-license"><div class="row"> <div class="col-sm-3 col-md-2"><a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" title=""><img src="https://licensebuttons.net/l/by/4.0//88x31.png" alt="Creative Common - by 4.0 "></a></div> <div class="col-sm-9 col-md-10"><a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" title="">This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</a></div> </div></div></section></article> </div> </div></div></section><div class="modal fade ModalDefault ModalTutors" id="ModalTutors" tabindex="-1" role="dialog" aria-hidden="true"><div class="modal-dialog"><div class="modal-content"> <div class="modal-header"> <h5 class="modal-title">Authorship</h5> <button class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button> </div> <div class="modal-body"> <div class="info"> <div class="tutors"> <strong> Marcos Vinícius Mendes DANTAS </strong><span class="ref footnote"><sup class="xref">*</sup><span class="refCtt closed"><span class="refCttPadding"><strong class="fn-title">*</strong>Marcos Vinícius Mendes Dantas, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, UNESP – Universidade Estadual Paulista, Rua Humaitá, 1680, Centro, 14801-903 Araraquara - SP, Brasil, e-mail: mvmdantas@hotmail.com </span></span></span><br><div> <span data-aff-display="aff01">Faculdade de Odontologia de Araraquara, UNESP – Universidade Estadual Paulista, Araraquara, SP, Brasil</span><span data-aff-orgname="aff01" hidden="">Universidade Estadual Paulista</span><span data-aff-country="aff01" hidden="">Brasil</span><span data-aff-country-code="aff01" hidden="" country="BR"></span><span data-aff-location="aff01" hidden="">Araraquara, SP, Brasil</span><span data-aff-full="aff01" hidden="">Faculdade de Odontologia de Araraquara, UNESP – Universidade Estadual Paulista, Araraquara, SP, Brasil</span><a href="" class="scimago-link" data-scimago-link="aff01"></a> </div> <div class="clearfix"></div> </div> <div class="tutors"> <strong> Bianca NESSO </strong><br><div> <span data-aff-display="aff01">Faculdade de Odontologia de Araraquara, UNESP – Universidade Estadual Paulista, Araraquara, SP, Brasil</span><span data-aff-orgname="aff01" hidden="">Universidade Estadual Paulista</span><span data-aff-country="aff01" hidden="">Brasil</span><span data-aff-country-code="aff01" hidden="" country="BR"></span><span data-aff-location="aff01" hidden="">Araraquara, SP, Brasil</span><span data-aff-full="aff01" hidden="">Faculdade de Odontologia de Araraquara, UNESP – Universidade Estadual Paulista, Araraquara, SP, Brasil</span><a href="" class="scimago-link" data-scimago-link="aff01"></a> </div> <div class="clearfix"></div> </div> <div class="tutors"> <strong> Daniel Sagawa MITUUTI </strong><br><div> <span data-aff-display="aff01">Faculdade de Odontologia de Araraquara, UNESP – Universidade Estadual Paulista, Araraquara, SP, Brasil</span><span data-aff-orgname="aff01" hidden="">Universidade Estadual Paulista</span><span data-aff-country="aff01" hidden="">Brasil</span><span data-aff-country-code="aff01" hidden="" country="BR"></span><span data-aff-location="aff01" hidden="">Araraquara, SP, Brasil</span><span data-aff-full="aff01" hidden="">Faculdade de Odontologia de Araraquara, UNESP – Universidade Estadual Paulista, Araraquara, SP, Brasil</span><a href="" class="scimago-link" data-scimago-link="aff01"></a> </div> <div class="clearfix"></div> </div> <div class="tutors"> <strong> Marisa Aparecida Cabrini GABRIELLI </strong><br><div> <span data-aff-display="aff01">Faculdade de Odontologia de Araraquara, UNESP – Universidade Estadual Paulista, Araraquara, SP, Brasil</span><span data-aff-orgname="aff01" hidden="">Universidade Estadual Paulista</span><span data-aff-country="aff01" hidden="">Brasil</span><span data-aff-country-code="aff01" hidden="" country="BR"></span><span data-aff-location="aff01" hidden="">Araraquara, SP, Brasil</span><span data-aff-full="aff01" hidden="">Faculdade de Odontologia de Araraquara, UNESP – Universidade Estadual Paulista, Araraquara, SP, Brasil</span><a href="" class="scimago-link" data-scimago-link="aff01"></a> </div> <div class="clearfix"></div> </div> </div> <div class="info"> <div>CONFLICTS OF INTERESTS The authors declare no conflicts of interest.</div> </div> <div class="corresp"> <a class="" name="c01_ref"></a><strong>*</strong>Marcos Vinícius Mendes Dantas, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, UNESP – Universidade Estadual Paulista, Rua Humaitá, 1680, Centro, 14801-903 Araraquara - SP, Brasil, e-mail: <a href="mailto:mvmdantas@hotmail.com">mvmdantas@hotmail.com</a> </div> </div> </div></div></div> <div class="modal fade ModalDefault ModalTutors" id="ModalScimago" tabindex="-1" role="dialog" aria-hidden="true"><div class="modal-dialog"><div class="modal-content"> <div class="modal-header"> <h5 class="modal-title"> SCIMAGO INSTITUTIONS RANKINGS </h5> <button class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button> </div> <div class="modal-body"><div class="info"><div> <span data-aff-display="aff01">Faculdade de Odontologia de Araraquara, UNESP – Universidade Estadual Paulista, Araraquara, SP, Brasil</span><span data-aff-orgname="aff01" hidden="">Universidade Estadual Paulista</span><span data-aff-country="aff01" hidden="">Brasil</span><span data-aff-country-code="aff01" hidden="" country="BR"></span><span data-aff-location="aff01" hidden="">Araraquara, SP, Brasil</span><span data-aff-full="aff01" hidden="">Faculdade de Odontologia de Araraquara, UNESP – Universidade Estadual Paulista, Araraquara, SP, Brasil</span><a href="" class="scimago-link" data-scimago-link="aff01"></a><br> </div></div></div> </div></div></div> <div class="modal fade ModalDefault" id="ModalTablesFigures" tabindex="-1" role="dialog" aria-hidden="true"><div class="modal-dialog"><div class="modal-content"> <div class="modal-header"> <h5 class="modal-title">Figures | Tables</h5> <button class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button> </div> <div class="modal-body"> <ul class="nav nav-tabs" role="tablist"> <li role="presentation" class="nav-item"><a href="#figures" class="nav-link active" data-bs-toggle="tab">Figures (1) </a></li> <li role="presentation" class="nav-item"><a href="#tables" class="nav-link" data-bs-toggle="tab">Tables (3) </a></li> </ul> <div class="clearfix"></div> <div class="tab-content"> <div class="tab-pane fade show active" id="figures" role="tabpanel" aria-labelledby="figures"><div class="row fig"> <div class="col-4"><a data-bs-toggle="modal" data-bs-target="#ModalFiggf01"><div class="thumbImg"> <img src="https://minio.scielo.br/documentstore/1807-2577/tjKGtmnFK4ZJmbYBctVvddh/d5158f5a217fae0aa44c7b488fa8c977bd77d774.jpg"> Thumbnail <div class="zoom"><span class="sci-ico-zoom"></span></div> </div></a></div> <div class="col-12"> <strong><strong>Figure 1</strong></strong><br> Percentages of responses to the Kleinknecht’s scale<span class="ref"><sup class="xref xrefblue"><a href="#B014_ref" data-ref="14 14 Kleinknecht RA, Bernstein DA. The assessment of dental fear. Behav Ther. 1978 Sep;9(4):626-34. http://dx.doi.org/10.1016/S0005-7894(78)80138-5. ">14</a></sup></span> scores. </div> </div></div> <div class="tab-pane fade show" id="tables" role="tabpanel" aria-labelledby="tables"> <div class="row table"> <div class="col-4"><a data-bs-toggle="modal" data-bs-target="#ModalTablet01"><div class="thumbOff"> Thumbnail <div class="zoom"><span class="sci-ico-zoom"></span></div> </div></a></div> <div class="col-12"> <strong><strong>Table 1</strong></strong><br> Means (standard deviations) of physiological indicators monitored in subjects under anesthesia with articaine, according to the 5 monitoring periods </div> </div> <div class="row table"> <div class="col-4"><a data-bs-toggle="modal" data-bs-target="#ModalTablet02"><div class="thumbOff"> Thumbnail <div class="zoom"><span class="sci-ico-zoom"></span></div> </div></a></div> <div class="col-12"> <strong><strong>Table 2</strong></strong><br> Means (standard deviations) of physiological indicators monitored in subjects under anesthesia with mepivacaine, according to the 5 monitoring periods </div> </div> <div class="row table"> <div class="col-4"><a data-bs-toggle="modal" data-bs-target="#ModalTablet03"><div class="thumbOff"> Thumbnail <div class="zoom"><span class="sci-ico-zoom"></span></div> </div></a></div> <div class="col-12"> <strong><strong>Table 3</strong></strong><br> Intensity of pain at the specified time points following the surgical procedure </div> </div> </div> </div> </div> </div></div></div> <div class="modal fade ModalFigs" id="ModalFiggf01" tabindex="-1" role="dialog" aria-hidden="true"><div class="modal-dialog modal-lg"><div class="modal-content"> <div class="modal-header"> <h5 class="modal-title"> <span class="material-icons-outlined">image</span><strong>Figure 1</strong> Percentages of responses to the Kleinknecht’s scale<span class="ref"><sup class="xref xrefblue"><a href="#B014_ref" data-ref="14 14 Kleinknecht RA, Bernstein DA. The assessment of dental fear. Behav Ther. 1978 Sep;9(4):626-34. http://dx.doi.org/10.1016/S0005-7894(78)80138-5. ">14</a></sup></span> scores. <a class="link-newWindow showTooltip" target="_blank" data-placement="left" title="Open new window" href="https://minio.scielo.br/documentstore/1807-2577/tjKGtmnFK4ZJmbYBctVvddh/884fdf6440f2a62e399c9abb43a47e1d231ff986.jpg"><span class="material-icons-outlined">open_in_new</span></a> </h5> <button class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button> </div> <div class="modal-body"><img style="max-width:100%" src="https://minio.scielo.br/documentstore/1807-2577/tjKGtmnFK4ZJmbYBctVvddh/884fdf6440f2a62e399c9abb43a47e1d231ff986.jpg"></div> </div></div></div> <div class="modal fade ModalTables" id="ModalTablet01" tabindex="-1" role="dialog" aria-hidden="true"><div class="modal-dialog modal-lg"><div class="modal-content"> <div class="modal-header"> <h5 class="modal-title"> <span class="material-icons-outlined">table_chart</span><strong><strong>Table 1</strong></strong> Means (standard deviations) of physiological indicators monitored in subjects under anesthesia with articaine, according to the 5 monitoring periods <br> </h5> <button class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button> </div> <div class="modal-body"><div class="table table-hover"><table frame="hsides" rules="groups"> <col width="23.41%"> <col width="13.35%"> <col width="13.33%"> <col width="17.05%"> <col width="17.05%"> <col width="15.81%"> <thead> <tr> <th align="center" scope="col" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>Indicator</b> </th> <th align="center" scope="col" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>T<sub>0</sub></b> </th> <th align="center" scope="col" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>T<sub>1</sub></b> </th> <th align="center" scope="col" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>T<sub>2</sub></b> </th> <th align="center" scope="col" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>T<sub>3</sub></b> </th> <th align="center" scope="col" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>T<sub>4</sub></b> </th> </tr> </thead> <tbody> <tr> <td align="center" scope="row" style="border-top: solid 1pt" valign="middle">SBP (mmHg)</td> <td align="center" style="border-top: solid 1pt" valign="middle">115 (10)<sup>a</sup> </td> <td align="center" style="border-top: solid 1pt" valign="middle">124 (13)<sup>b</sup> </td> <td align="center" style="border-top: solid 1pt" valign="middle">124 (14)<sup>b</sup> </td> <td align="center" style="border-top: solid 1pt" valign="middle">119 (13)<sup>a</sup> </td> <td align="center" style="border-top: solid 1pt" valign="middle">115 (12)<sup>a</sup> </td> </tr> <tr> <td align="center" scope="row" style="background-color:rgb(217,217,217)" valign="middle">DBP (mmHg)</td> <td align="center" style="background-color:rgb(217,217,217)" valign="middle">74 (9)<sup>a</sup> </td> <td align="center" style="background-color:rgb(217,217,217)" valign="middle">80 (9)<sup>c</sup> </td> <td align="center" style="background-color:rgb(217,217,217)" valign="middle">79 (9)<sup>bc</sup> </td> <td align="center" style="background-color:rgb(217,217,217)" valign="middle">77 (8)<sup>ab</sup> </td> <td align="center" style="background-color:rgb(217,217,217)" valign="middle">75 (8)<sup>a</sup> </td> </tr> <tr> <td align="center" scope="row" valign="middle">Saturation (%)</td> <td align="center" valign="middle">98 (2)<sup>a</sup> </td> <td align="center" valign="middle">98 (1)<sup>a</sup> </td> <td align="center" valign="middle">98 (1)<sup>a</sup> </td> <td align="center" valign="middle">97 (3)<sup>a</sup> </td> <td align="center" valign="middle">97 (2)<sup>a</sup> </td> </tr> <tr> <td align="center" scope="row" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="middle">Rate (bpm)</td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="middle">78 (13)<sup>a</sup> </td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="middle">93 (15)<sup>b</sup> </td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="middle">89 (14)<sup>b</sup> </td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="middle">83 (10)<sup>a</sup> </td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="middle">81 (12)<sup>a</sup> </td> </tr> </tbody> </table></div></div> <div class="modal-footer"><div class="ref-list"><ul class="refList footnote"><li fn-type="other"> <div>Means with equal letters in the same line are not significantly different by the Tukey test (p>0.05).</div> </li></ul></div></div> </div></div></div> <div class="modal fade ModalTables" id="ModalTablet02" tabindex="-1" role="dialog" aria-hidden="true"><div class="modal-dialog modal-lg"><div class="modal-content"> <div class="modal-header"> <h5 class="modal-title"> <span class="material-icons-outlined">table_chart</span><strong><strong>Table 2</strong></strong> Means (standard deviations) of physiological indicators monitored in subjects under anesthesia with mepivacaine, according to the 5 monitoring periods <br> </h5> <button class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button> </div> <div class="modal-body"><div class="table table-hover"><table frame="hsides" rules="groups"> <col width="23.38%"> <col width="13.35%"> <col width="13.32%"> <col width="17.05%"> <col width="17.06%"> <col width="15.84%"> <thead> <tr> <th align="center" scope="col" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>Indicator</b> </th> <th align="center" scope="col" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>T<sub>0</sub></b> </th> <th align="center" scope="col" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>T<sub>1</sub></b> </th> <th align="center" scope="col" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>T<sub>2</sub></b> </th> <th align="center" scope="col" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>T<sub>3</sub></b> </th> <th align="center" scope="col" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>T<sub>4</sub></b> </th> </tr> </thead> <tbody> <tr> <td align="center" scope="row" style="border-top: solid 1pt" valign="middle">SBP (mmHg)</td> <td align="center" style="border-top: solid 1pt" valign="middle">114 (13)<sup>a</sup> </td> <td align="center" style="border-top: solid 1pt" valign="middle">126 (14)<sup>c</sup> </td> <td align="center" style="border-top: solid 1pt" valign="middle">126 (15)<sup>bc</sup> </td> <td align="center" style="border-top: solid 1pt" valign="middle">121 (11)<sup>b</sup> </td> <td align="center" style="border-top: solid 1pt" valign="middle">114 (11)<sup>a</sup> </td> </tr> <tr> <td align="center" scope="row" style="background-color:rgb(217,217,217)" valign="middle">DBP (mmHg)</td> <td align="center" style="background-color:rgb(217,217,217)" valign="middle">72 (10)<sup>a</sup> </td> <td align="center" style="background-color:rgb(217,217,217)" valign="middle">78 (8)<sup>c</sup> </td> <td align="center" style="background-color:rgb(217,217,217)" valign="middle">79 (9)<sup>c</sup> </td> <td align="center" style="background-color:rgb(217,217,217)" valign="middle">77 (8)<sup>bc</sup> </td> <td align="center" style="background-color:rgb(217,217,217)" valign="middle">74 (7)<sup>ab</sup> </td> </tr> <tr> <td align="center" scope="row" valign="middle">Saturation (%)</td> <td align="center" valign="middle">97 (2)<sup>a</sup> </td> <td align="center" valign="middle">98 (2)<sup>a</sup> </td> <td align="center" valign="middle">98 (1)<sup>a</sup> </td> <td align="center" valign="middle">97 (2)<sup>a</sup> </td> <td align="center" valign="middle">97 (2)<sup>a</sup> </td> </tr> <tr> <td align="center" scope="row" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="middle">Rate (bpm)</td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="middle">77 (16)<sup>a</sup> </td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="middle">97 (18)<sup>d</sup> </td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="middle">90 (14)<sup>cd</sup> </td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="middle">85 (13)<sup>bc</sup> </td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="middle">82 (13)<sup>ab</sup> </td> </tr> </tbody> </table></div></div> <div class="modal-footer"><div class="ref-list"><ul class="refList footnote"><li fn-type="other"> <div>Means with equal letters in the same line are not significantly different by the Tukey test (p>0.05).</div> </li></ul></div></div> </div></div></div> <div class="modal fade ModalTables" id="ModalTablet03" tabindex="-1" role="dialog" aria-hidden="true"><div class="modal-dialog modal-lg"><div class="modal-content"> <div class="modal-header"> <h5 class="modal-title"> <span class="material-icons-outlined">table_chart</span><strong><strong>Table 3</strong></strong> Intensity of pain at the specified time points following the surgical procedure <br> </h5> <button class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button> </div> <div class="modal-body"><div class="table table-hover"><table frame="hsides" rules="groups"> <col width="20.35%"> <col width="19.94%"> <col width="19.92%"> <col width="19.92%"> <col width="19.87%"> <thead> <tr> <th align="center" rowspan="2" scope="col" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>Anesthetic</b> </th> <th align="center" colspan="4" scope="colgroup" style="border-top: solid 2.25pt; border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>Post-operative period (h)</b> </th> </tr> <tr> <th align="center" colspan="1" scope="colgroup" style="border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>12</b> </th> <th align="center" scope="col" style="border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>24</b> </th> <th align="center" scope="col" style="border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>36</b> </th> <th align="center" scope="col" style="border-bottom: solid 1pt; background-color:rgb(217,217,217)" valign="middle"> <b>48</b> </th> </tr> </thead> <tbody> <tr> <td align="center" scope="row" style="border-top: solid 1pt" valign="bottom">Articaine</td> <td align="center" style="border-top: solid 1pt" valign="bottom">4(3)<sup>c</sup> </td> <td align="center" style="border-top: solid 1pt" valign="bottom">3 (2)<sup>b</sup> </td> <td align="center" style="border-top: solid 1pt" valign="bottom">2 (2)<sup>a</sup> </td> <td align="center" style="border-top: solid 1pt" valign="bottom">1 (2)<sup>a</sup> </td> </tr> <tr> <td align="center" scope="row" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="bottom">Mepivacaine</td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="bottom">5 (3)<sup>c</sup> </td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="bottom">4 (3)<sup>bc</sup> </td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="bottom">3 (3)<sup>ab</sup> </td> <td align="center" style="border-bottom: solid 2.25pt; background-color:rgb(217,217,217)" valign="bottom">2 (2)<sup>a</sup> </td> </tr> </tbody> </table></div></div> <div class="modal-footer"><div class="ref-list"><ul class="refList footnote"><li fn-type="other"> <div>Means with equal letters in the same line are not significantly different by the Tukey test (p>0.05).</div> </li></ul></div></div> </div></div></div> <div class="modal fade ModalDefault" id="ModalArticles" tabindex="-1" role="dialog" aria-hidden="true"><div class="modal-dialog"><div class="modal-content"> <div class="modal-header"> <h5 class="modal-title">How to cite</h5> <button class="btn-close" data-bs-dismiss="modal" aria-label="Close"></button> </div> <div class="modal-body"> <p id="citation"></p> <input id="citationCut" type="text" value=""><a class="btn btn-secondary btn-sm scielo__btn-with-icon--left copyLink" data-clipboard-target="#citationCut"><span class="material-icons-outlined">link</span>copy</a> </div> </div></div></div> <script type="text/javascript"> function currentDate() { var today = new Date(); 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Assessment of patient’s anxiety and expectation associated with hemodynamic changes during surgical procedure under local anesthesia. Revista de Odontologia da UNESP [online]. 2017, v. 46, n. 5 [Accessed CURRENTDATE], pp. 299-306. Available from: <https://doi.org/10.1590/1807-2577.02917>. Epub Sep-Oct 2017. 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