ASH 2024: Regeneron’s Ordspono faces challenges, but positive results signal hope

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Opinion</a></li> <li class=""><a href="https://www.pharmaceutical-technology.com/data-insights/">Data Insights</a></li> </ul> </div> </div> </div> </nav> <div class="menu-bg"></div> </header> <main class="article-page gdm-opinion-article"> <article> <div class="grid-x"> <div class="cell large-8"> <header class="article-header"> <div class="breadcrumbs-container"> <ul class="breadcrumbs"> <li class="breadcrumbs-item"> <a href="https://www.pharmaceutical-technology.com/analyst-comment/" class="c-post-content__category">Analyst Comment</a> </li> </ul> <div class="date"> <span class="date-published"></span> </div> </div>  <div class="article-header__content"> <h1 class="article-header__title">ASH 2024: Regeneron’s Ordspono faces challenges, but positive results signal hope</h1> <p class="article-header__excerpt">While 88.1% of patients completed one cycle, patient adherence beyond the fourth cycle was relatively low.</p> <div class="article-meta"> <span class="article-author"><a href="https://www.pharmaceutical-technology.com/author/globaldata/" title="Posts by GlobalData Healthcare" class="author url fn" rel="author">GlobalData Healthcare</a></span> <span class="date-published">December 10, 2024</span>  </div>  <div class="gdm-article-actions"> <div class="gdm-article-share"> <span class="button-toggle transparent-with-border gdm-article-share__button">Share <ul class="gdm-article-share-list__container"> <li><a href="https://www.pharmaceutical-technology.com/analyst-comment/ash-2024-regenerons-ordspono-faces-challenges-but-positive-results-signal-hope/" class="copy-link">Copy Link</a></li> <li><a href="https://twitter.com/intent/tweet?text=ASH+2024%3A+Regeneron%E2%80%99s+Ordspono+faces+challenges%2C+but+positive+results+signal+hope%0a&url=https://www.pharmaceutical-technology.com/analyst-comment/ash-2024-regenerons-ordspono-faces-challenges-but-positive-results-signal-hope/&via=PharmaTechFocus" class="x-share" target="_blank">Share on X</a></li> <li><a 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srcset="https://live-b2b-gdm-figaro1.pantheonsite.io/wp-content/uploads/sites/24/2024/12/shutterstock_1665700435-940x528.jpg" /> <img src="https://live-b2b-gdm-figaro1.pantheonsite.io/wp-content/uploads/sites/24/2024/12/shutterstock_1665700435-430x241.jpg" alt="" /> </picture> <figcaption class="c-featured-image__description">Pleural fluid cytology showing involvement by malignant cells of a mantle cell lymphoma, pleomorphic variant.. Image credit: Shutterstock/David A Litman</figcaption> </figure> </div> <p class="drop-cap">Data from the Phase II ELM-2 trial was presented at the American Society of Hematology (ASH) 2024 Annual Meeting, held on December 7–10. The trial evaluated Regeneron’s Ordspono (odronextamab) for relapsed/refractory (r/r) marginal zone lymphoma (MZL) in extranodal, nodal, and splenic locations in patients who had undergone second-line or later systemic therapy. The limited treatment options in the third-line setting for MZL highlight a significant opportunity for novel therapeutic modalities, such as bispecific antibodies, to fill this gap.</p> <p>Ordspono is a CD20xCD3 bispecific monoclonal antibody that facilitates T cell engagement for the targeted killing of CD20-expressing tumor B cells. The Phase II ELM-2 study implemented a step-up dosing strategy to mitigate cytokine release syndrome (CRS), followed by maintenance dosing every two weeks or every four weeks for patients who achieved a complete response (CR) lasting over nine months. While 88.1% of patients completed one cycle, patient adherence beyond the fourth cycle was relatively low (64.3%), highlighting a potential challenge in long-term administration. The trial reported promising efficacy with an objective response rate (ORR) and CR rate of 77.1% each (95% CI 59.9–89.6). The 12-month duration of response (DOR) was 80.2 (95% CI 49.6–93.3), indicating a durable response. However, the overall median DOR, median duration of complete response (DOCR), median progression-free survival (PFS), and median overall survival (OS) were not reached, with a median of 11 months.</p><div class="cell large-2 sidebar-scalar mobile-only"> <div class="gdm-widget gdm-recommended-reports gdm-pi-recommended-reports gdm-orange-banner recommended-whitepapers"><h3>Go deeper with GlobalData</h3><ul><li class="grid-x"><div class="cell small-2"><figure><a href=""><img decoding="async" src="https://pr-fr-json-b2b-gdm-figaro1.pantheonsite.io/pharmaceutical-technology/wp-content/themes/goodlife-wp-B2B/assets/img/report.png" alt="ReportsLogo" /></a></figure></div><div class="cell small-10 details"><div class="category"><a href="https://www.globaldata.com/store/report/" target="_blank">Reports</a></div><h4><a href=https://www.globaldata.com/store/report/ims-001-in-relapsing-remitting-multiple-sclerosis-rrms-loa-and-ptsr-drug-analysis-299042?scalar=true&pid=342057&sid=24 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</svg> Data Insights </h5> <p> The gold standard of business intelligence. </p> <p class="find-out-more"><a href="https://www.pharmaceutical-technology.com/buy-reports/?utm_source=LGP-Article&utm_content=Find_out_more&utm_campaign=LGP_Premium-Insight-Landing-Page" target="_blank"> Find out more <svg xmlns="http://www.w3.org/2000/svg" width="16" height="10" viewBox="0 0 16 10" fill="none"> <path d="M1 1.48846L8.02309 8.51156L15.0462 1.48846" stroke="#FF5D2B" stroke-linecap="round"></path> </svg> </a> </p> </div> </div><div class="sidebar-content company-comment"><div class="gd-widget related-company-profiles"><header><h3>Related Company Profiles</h3></header><div class="grid-x"><article class="cell large-12"><h4><a href=https://www.globaldata.com/store/report/?cdmsid=1695074&scalar=true&pid=342057&sid=24 target="_blank">Regeneron Pharmaceuticals Inc</a></h4></article><article class="cell large-12"><h4><a href=https://www.globaldata.com/store/report/?cdmsid=1649729&scalar=true&pid=342057&sid=24 target="_blank">AbbVie Inc</a></h4></article><article class="cell large-12"><h4><a href=https://www.globaldata.com/store/report/?cdmsid=1395103&scalar=true&pid=342057&sid=24 target="_blank">Genmab AS</a></h4></article><article class="cell large-12"><h4><a href=https://www.globaldata.com/store/report/?cdmsid=1595583&scalar=true&pid=342057&sid=24 target="_blank">Roche Diagnostics International Ltd</a></h4></article><span class="view-all mobile-only"><a href="https://www.globaldata.com/companies/" target="_blank" class="new-window">View all</a></span></div></div></div></div> <p>The safety profile was generally manageable. Common treatment-emergent adverse events (TEAEs) included CRS (54.8%), infusion-related reaction (35.7%), pyrexia (35.7%), and neutropenia (31%). Grade 3 or higher TEAEs occurred in 83.3% of patients, the most common of which was neutropenia (23.8%). Notably, CRS was reported in 56.5% of patients who received the step-up regimen. All CRS events were limited to grade 1–2 severity, reflecting the effectiveness of step-up dosing and prophylactic steroid use. Additionally, no cases of immune effector cell-associated neurotoxicity syndrome (ICANS) events were observed, further supporting the safety profile.</p><div id="slot-one"></div> <p>Overall, Ordspono demonstrates promising clinical efficacy and a manageable safety profile in r/r MZL, but challenges persist. The FDA rejected Regeneron’s biologics license application for Ordspono, as the confirmatory trials were not underway, and the agency required Regeneron to establish a clear timeline before resubmission. This regulatory setback could delay broader US market adoption, affecting its competitiveness. However, Ordspono received European Commission approval earlier this year based on the same Phase II ELM-2 trial for treating adult patients with r/r FL or r/r diffuse large B-cell lymphoma (DLBCL) after two or more lines of systemic therapy. This approval indicates regulatory confidence and may make future expansion into MZL, an indolent lymphoma similar to FL, possible.</p> <p>Ordspono faces pressures from other bispecific T-cell engager therapies (BiTEs), like <a href="https://www.globaldata.com/store/report/?cdmsid=1649729&scalar=true&utm_source=Analyst Comment&utm_medium=24-342057&utm_campaign=company-profile-hyperlink-nonlgp" target="_blank">AbbVie</a> and <a href="https://www.globaldata.com/store/report/?cdmsid=1395103&scalar=true&utm_source=Analyst Comment&utm_medium=24-342057&utm_campaign=company-profile-hyperlink-nonlgp" target="_blank">Genmab</a>‘s Epkinly (epcoritamab), Roche’s Columvi (glofitamab), and Roche’s Lunsumio (mosunetuzumab). In terms of route of administration, Ordspono’s intravenous administration is less convenient than Epkinly’s subcutaneous administration. While Columvi and Lunsumio are also intravenously administered, their dosing schedules are more defined and less frequent than that of Ordspono, which occurs over two days. Additionally, increasing the limited sample size within the study poses another challenge given the rarity of MZL. GlobalData’s analyst consensus forecast projects Ordspono’s total global sales to reach $569 million by 2030, contingent on confirmatory trials that provide robust comparisons to standard-of-care treatments or competing BiTEs. Regeneron’s OLYMPIA odronextamab development program is expected to establish Ordspono’s niche in several B-cell non-Hodgkin lymphoma subtypes and earlier lines of therapy with multiple ongoing studies, such as the Phase III OLYMPIA-5 trial evaluating odronextamab-lenalidomide versus lenalidomide-rituximab (R2) including a cohort of patients with r/r MZL. If these challenges are addressed, Ordspono could represent a significant advancement in the treatment landscape across other B-cell malignancies and potentially expand its impact to the underserved third-line MZL setting.</p> <div id="Sgpollsputhere"></div><div id="slot-three"></div></p><div class="gdm-company-profile-unit" id="company_profile_form"> <h1 class="gdm-company-profile-unit__heading">How well do you <span style="text-decoration: underline;">really</span> know your competitors?</h1> <p class="gdm-company-profile-unit__sub-heading">Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. 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permutive.segment(40190, function(result){ if (result && getCookie('Smartstream') !== "shown") { jQuery('#Smartstream').css('display','block'); setCookie('Smartstream', 'shown', 7) permutive.track('ipTarget', { company:company_id, target_reason: "Smartstream", content: "Fit for the future, whatever it looks like", content_type: "targeted popup", content_url: "https://www.verdict.co.uk/private-banker-international/future-banking-technology/fit-for-the-future-whatever-it-looks-like/" }) } }); permutive.segment(30918, function(result){ if (result && getCookie('target-novotech') !== "shown") { jQuery('#target-novotech').css('display','block'); setCookie('target-novotech', 'shown', 1) permutive.track('ipTarget', { company:company_id, target_reason: "Accelerating Clinical Trials", content: "Clinical Trial Continuity in Asia-Pacific during the COVID-19 pandemic", content_type: "targeted popup", content_url: "https://www.pharmaceutical-technology.com/sponsored/clinical-trial-continuity-in-asia-pacific-during-the-covid-19-pandemic/" }) } }); 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}) </script> <script> jQuery( document ).ready(function() { function vmsnewTargetpopup(p1,p2,p3){ if( p1 != null && p2 !== null ) { jQuery.ajax({ type: "POST", url: "https://www.pharmaceutical-technology.com/wp-content/themes/goodlife-wp-B2B/target_modal.php", dataType: "html", data: { "segmentid": p1, "blogid": p2, }, success: function(data){ if( data.indexOf("false_partner") >= 0 ){ return false; //setCookie("target-"+p1+"_"+'24', 'shown', 1); }else{ jQuery(p3).html(data); //setCookie("target-"+p1+"_"+'24', 'shown', 1); } } }); } } var per_loop =1; permutive.segment(164191, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(164191); if(per_loop==1){ vmsnewTargetpopup(164191, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(164191, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(164191, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(106931, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(106931); 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//console.log(88696); if(per_loop==1){ vmsnewTargetpopup(88696, 26, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(88696, 26,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(88696, 26, '#resultnew_third'); } per_loop++; } } }); permutive.segment(77419, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(77419); if(per_loop==1){ vmsnewTargetpopup(77419, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(77419, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(77419, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(83486, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(83486); if(per_loop==1){ vmsnewTargetpopup(83486, 17, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(83486, 17,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(83486, 17, '#resultnew_third'); } per_loop++; } } }); permutive.segment(199185, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(199185); if(per_loop==1){ vmsnewTargetpopup(199185, 30, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(199185, 30,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(199185, 30, '#resultnew_third'); } per_loop++; } } }); permutive.segment(72674, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(72674); if(per_loop==1){ vmsnewTargetpopup(72674, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(72674, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(72674, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(33196, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(33196); if(per_loop==1){ vmsnewTargetpopup(33196, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(33196, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(33196, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(202734, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(202734); if(per_loop==1){ vmsnewTargetpopup(202734, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(202734, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(202734, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(46314, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(46314); if(per_loop==1){ vmsnewTargetpopup(46314, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(46314, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(46314, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(106166, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(106166); if(per_loop==1){ vmsnewTargetpopup(106166, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(106166, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(106166, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(126060, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(126060); if(per_loop==1){ vmsnewTargetpopup(126060, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(126060, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(126060, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(176648, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(176648); if(per_loop==1){ vmsnewTargetpopup(176648, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(176648, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(176648, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(35985, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(35985); if(per_loop==1){ vmsnewTargetpopup(35985, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(35985, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(35985, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(44506, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(44506); if(per_loop==1){ vmsnewTargetpopup(44506, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(44506, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(44506, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(80549, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(80549); if(per_loop==1){ vmsnewTargetpopup(80549, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(80549, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(80549, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(116879, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(116879); if(per_loop==1){ vmsnewTargetpopup(116879, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(116879, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(116879, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(187596, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(187596); if(per_loop==1){ vmsnewTargetpopup(187596, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(187596, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(187596, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(212764, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(212764); if(per_loop==1){ vmsnewTargetpopup(212764, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(212764, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(212764, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(187960, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(187960); if(per_loop==1){ vmsnewTargetpopup(187960, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(187960, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(187960, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(202734, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(202734); if(per_loop==1){ vmsnewTargetpopup(202734, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(202734, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(202734, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(190006, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(190006); if(per_loop==1){ vmsnewTargetpopup(190006, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(190006, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(190006, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(126060, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(126060); if(per_loop==1){ vmsnewTargetpopup(126060, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(126060, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(126060, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(71444, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(71444); if(per_loop==1){ vmsnewTargetpopup(71444, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(71444, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(71444, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(39494, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(39494); if(per_loop==1){ vmsnewTargetpopup(39494, 22, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(39494, 22,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(39494, 22, '#resultnew_third'); } per_loop++; } } }); permutive.segment(207353, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(207353); if(per_loop==1){ vmsnewTargetpopup(207353, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(207353, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(207353, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(195099, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(195099); if(per_loop==1){ vmsnewTargetpopup(195099, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(195099, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(195099, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(20070, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(20070); if(per_loop==1){ vmsnewTargetpopup(20070, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(20070, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(20070, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(39494, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(39494); if(per_loop==1){ vmsnewTargetpopup(39494, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(39494, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(39494, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(39494, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(39494); if(per_loop==1){ vmsnewTargetpopup(39494, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(39494, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(39494, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(100301, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(100301); if(per_loop==1){ vmsnewTargetpopup(100301, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(100301, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(100301, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(187960, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(187960); if(per_loop==1){ vmsnewTargetpopup(187960, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(187960, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(187960, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(39150, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(39150); if(per_loop==1){ vmsnewTargetpopup(39150, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(39150, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(39150, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(209867, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(209867); if(per_loop==1){ vmsnewTargetpopup(209867, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(209867, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(209867, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(189369, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(189369); if(per_loop==1){ vmsnewTargetpopup(189369, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(189369, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(189369, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(98233, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(98233); if(per_loop==1){ vmsnewTargetpopup(98233, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(98233, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(98233, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(167527, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(167527); if(per_loop==1){ vmsnewTargetpopup(167527, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(167527, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(167527, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(185678, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(185678); if(per_loop==1){ vmsnewTargetpopup(185678, 2, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(185678, 2,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(185678, 2, '#resultnew_third'); } per_loop++; } } }); permutive.segment(98259, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(98259); if(per_loop==1){ vmsnewTargetpopup(98259, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(98259, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(98259, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(199243, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(199243); if(per_loop==1){ vmsnewTargetpopup(199243, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(199243, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(199243, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(193412, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(193412); if(per_loop==1){ vmsnewTargetpopup(193412, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(193412, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(193412, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(103918, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(103918); if(per_loop==1){ vmsnewTargetpopup(103918, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(103918, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(103918, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(47155, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(47155); if(per_loop==1){ vmsnewTargetpopup(47155, 26, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(47155, 26,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(47155, 26, '#resultnew_third'); } per_loop++; } } }); permutive.segment(207295, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(207295); if(per_loop==1){ vmsnewTargetpopup(207295, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(207295, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(207295, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(122205, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(122205); if(per_loop==1){ vmsnewTargetpopup(122205, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(122205, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(122205, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(141355, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(141355); if(per_loop==1){ vmsnewTargetpopup(141355, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(141355, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(141355, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(53241, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(53241); if(per_loop==1){ vmsnewTargetpopup(53241, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(53241, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(53241, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(130373, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(130373); if(per_loop==1){ vmsnewTargetpopup(130373, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(130373, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(130373, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(104754, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(104754); if(per_loop==1){ vmsnewTargetpopup(104754, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(104754, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(104754, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(72134, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(72134); if(per_loop==1){ vmsnewTargetpopup(72134, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(72134, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(72134, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(155983, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(155983); if(per_loop==1){ vmsnewTargetpopup(155983, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(155983, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(155983, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(133631, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(133631); if(per_loop==1){ vmsnewTargetpopup(133631, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(133631, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(133631, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(172149, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(172149); if(per_loop==1){ vmsnewTargetpopup(172149, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(172149, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(172149, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(176357, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(176357); if(per_loop==1){ vmsnewTargetpopup(176357, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(176357, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(176357, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(181571, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(181571); if(per_loop==1){ vmsnewTargetpopup(181571, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(181571, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(181571, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(61894, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(61894); if(per_loop==1){ vmsnewTargetpopup(61894, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(61894, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(61894, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(27581, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(27581); if(per_loop==1){ vmsnewTargetpopup(27581, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(27581, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(27581, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(199290, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(199290); if(per_loop==1){ vmsnewTargetpopup(199290, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(199290, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(199290, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(178673, function(result){ if(per_loop<4){ if (result) { console.log(result); //console.log(178673); if(per_loop==1){ vmsnewTargetpopup(178673, 24, '#resultnew'); }if(per_loop==2){ vmsnewTargetpopup(178673, 24,'#resultnew_secondary'); }if(per_loop==3){ vmsnewTargetpopup(178673, 24, '#resultnew_third'); } per_loop++; } } }); permutive.segment(131507, function(result){ if(per_loop<4){ if (result) { console.log(result); 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ASH 2024: Regeneron’s Ordspono faces challenges, but positive results signal hope - Pharmaceutical Technology