GeCIPing Sarcoma : University College London Hospitals NHS Foundation Trust

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href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/rnoh-cns-ahp-team-win-macmillan-professionals-excellence-award" target="_self" class="nav-item " tabindex="-1">RNOH CNS & AHP Team win Macmillan Professionals Excellence Award!</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/rnoh-wins-physiotherapy-excellence-award" target="_self" class="nav-item " tabindex="-1">RNOH WINS PHYSIOTHERAPY EXCELLENCE AWARD</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/review-emsos-2022" target="_self" class="nav-item " tabindex="-1">EMSOS 2022</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a 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href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/goodybe-and-good-luck-dr-seddon" target="_self" class="nav-item " tabindex="-1">Goodbye and Good Luck Dr Seddon!</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/sarcoma-awareness-month-2023" target="_self" class="nav-item " tabindex="-1">SARCOMA AWARENESS MONTH 2023</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/congratulations-professor-strauss" target="_self" class="nav-item " tabindex="-1">Congratulations Professor Strauss!</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/sarcoma-awareness-month-team-picnic" target="_self" class="nav-item " tabindex="-1">Sarcoma Awareness Month Team Picnic</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/rnoh-cuppa-and-cake-event-raises-428" target="_self" class="nav-item " tabindex="-1">RNOH Cuppa and Cake Event raises £428</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/sarcoma-awareness-month-stall" target="_self" class="nav-item " tabindex="-1">Sarcoma Awareness Month Stall</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/london-sarcoma-strategy-day" target="_self" class="nav-item " tabindex="-1">The London Sarcoma Strategy Day</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/rnoh-wins-noa-awards-2023" target="_self" class="nav-item " tabindex="-1">RNOH wins at NOA Awards 2023!</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/new-soft-tissue-sarcoma-hub-and-spoke-services-london" target="_self" class="nav-item " tabindex="-1">New hub and spoke GP urgent referral process for adult soft tissue sarcoma</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/ctos-dublin-2023" target="_self" class="nav-item " tabindex="-1">CTOS Dublin 2023</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/london-sarcoma-support-group" target="_self" class="nav-item " tabindex="-1">London Sarcoma Support Group</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/congratulations-anne-mctiernan-winning-sarcoma-uks-inaugural-shining-star-award" target="_self" class="nav-item " tabindex="-1">Congratulations to Anne McTiernan and Jo Coleman on winning Sarcoma UK’s inaugural Shining Star award</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/congratulations-mr-vasilios-karavasilis" target="_self" class="nav-item " tabindex="-1">Congratulations Dr Vasilios Karavasilis</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/fundraising-rare-cancer" target="_self" class="nav-item " tabindex="-1">Fundraising for RARE Cancer</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/surgeon-year" target="_self" class="nav-item " tabindex="-1">Surgeon of the Year</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/wood-green-community-diagnostic-centre-prior-suspected-cancer-referral" target="_self" class="nav-item " tabindex="-1">Wood Green Community Diagnostic Centre (prior to a suspected cancer referral)</a> </div></li><li class=" level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/additional-sarcoma-diagnostic-spoke-goes-live-barts-health" target="_self" class="nav-item " tabindex="-1">Additional Sarcoma diagnostic ‘spoke’ goes live at Barts Health</a> </div></li><li class="nav-last level-2 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news/pilot-virtual-hope-help-overcome-problems-effectively-programme" target="_self" class="nav-item nav-last " tabindex="-1">Pilot of the Virtual HOPE [Help Overcome Problems Effectively] Programme with Sarcoma Cohort at RNOH receives commendation at international meeting</a> </div></li></ul></div></div></li><li class="nav-dropdown hidden-md hidden-lg level-1 contact_us"><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/contact-us" target="_self" class="nav-item nav-dropdown hidden-md hidden-lg " aria-haspopup="true">Contact us</a> <button class="sub-button" title="Open Contact us submenu" aria-label="Contact us submenu" type="button" aria-expanded="false"><span></span></button><div class="sub-menu nav-dropdown hidden-md hidden-lg level-2"><ul class="sub-menu-list"><li 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hidden-md hidden-lg " tabindex="-1">Radiotherapy</a> </div></li><li class="hidden-md hidden-lg level-3 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/treating-sarcoma/chemotherapy" target="_self" class="nav-item hidden-md hidden-lg " tabindex="-1">Chemotherapy</a> </div></li><li class="hidden-md hidden-lg level-3 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/treating-sarcoma/shared-care" target="_self" class="nav-item hidden-md hidden-lg " tabindex="-1">Shared Care</a> </div></li><li class="hidden-md hidden-lg level-3 "><div class="item-wrapper"><a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/treating-sarcoma/ablative-therapies" target="_self" class="nav-item hidden-md hidden-lg " tabindex="-1">Interventional Therapies</a> 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href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-research/genomics/geciping-sarcoma" target="_self">GeCIPing Sarcoma</a></li></ol></nav> <div class="breadcrumb-back"> <a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-research/genomics" class="button-link arrow-left">Back to Genomics</a> </div> </div> </div> </div> </div> </div> </div> <div class="main-content "> <div class="container"> <div class="row"> <div class="col-md-6 hidden-md hidden-lg"> <div class="sidebar sidebar-nav"> <div class="core-style"> <div class="single-accordion default open"> <h2 class="single-accordion-title-shell"> <button type="button" aria-expanded="true" aria-controls="sidebar-nav" id="sidebar-nav-btn">In this section</button> </h2> <div class="single-accordion-content-wrapper" aria-labelledby="sidebar-nav-btn" id="sidebar-nav"> <div class="single-accordion-content"> <ul class="sidebar-list"> <li class=" "> <a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-research/genomics/100000-genomes-project" target="_self" >The 100,000 Genomes Project</a> </li> <li class=" "> <a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-research/genomics/whole-genome-sequencing" target="_self" >Whole Genome Sequencing</a> </li> <li class="active "> <a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-research/genomics/geciping-sarcoma" target="_self" >GeCIPing Sarcoma</a> </li> <li class=" "> <a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-research/genomics/tom-prince-osteosarcoma-research-project" target="_self" >Tom Prince Osteosarcoma Research Project</a> </li> <li class=" "> <a href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-research/genomics/genomics-malignant-peripheral-nerve-sheath-tumour-gem-consortium" target="_self" >Genomics of Malignant Peripheral Nerve Sheath Tumour (GEM) Consortium</a> </li> </ul> </div> </div> </div> </div> </div> </div> <div class="col-md-17"> <div class="main-content-column"> <div class="content-wrapper"> <div class="core-style"> <div class="content-block clearfix"> <p style="text-align:justify"><span><span>The Sarcoma Genomics England Clinical Interpretation Partnership (GeCIP), led by Professor Adrienne Flanagan of the London Sarcoma Service, brings together sarcoma researchers and clinicians in the UK to process, analyse and interpret the genomics data generated by the 100,000 Genomes Project. Key partners in the genomics working group include scientists from the Francis Crick Institute, University College London,  University of Birmingham and the Wellcome Trust Sanger Institute.</span></span></p> <p style="text-align:justify"><span><span>The genomic datasets from sarcoma participants will allow the team to discover genomic mutations (CNVs, SNVs, SVs, indels) contributing to the tumour initiation, development, evolution and intra-tumour heterogeneity. Additional ongoing research studies, led by various Sarcoma GeCIP members, to decipher the transcriptomic and epigenomic landscape of these sarcoma samples from the 100,000 Genomes Project will further contribute to a comprehensive understanding of the recurrent genetic driver mutations in a range of sarcoma subtypes and help to identify and better define the different tumours.</span></span></p> <p style="text-align:justify"><span><span>Dr Nischalan Pillay, Honorary Consultant Pathologist at RNOH and Cancer Research UK clinician scientist is a member of the team co-ordinating the analysis of the sarcoma genomes. Dr Pillay’s lab is focussed on unravelling the complex genetics of some sarcoma subtypes for clinical benefit (<a href="https://www.ucl.ac.uk/cancer/research/department-pathology/sarcoma-biology-and-genomics" target="_blank" data-link_text="https://www.ucl.ac.uk/cancer/research/department-pathology/sarcoma-biology-and-genomics">https://<wbr>www.<wbr>ucl.ac.uk/<wbr>cancer/<wbr>research/<wbr>department-pathology/<wbr>sarcoma-biology-and-genomics</a>). Recently Dr Christopher Steele in the Pillay lab developed a novel method to extract biologically and clinically useful information from the genomes undifferentiated pleomorphic sarcomas which was published in Cancer Cell (<a href="https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30097-2" target="_blank" data-link_text="https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30097-2)">https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30097-2)</a>. Ms Shadi Hames, a PhD student funded by Sarcoma UK (Sayako Grace Robinson fellowship) will work with Dr Steele to apply this method to the sarcoma genomes sequenced by GEL which has many other sarcoma subtypes. She will also be investigating the genetic determinants of immune evasion in sarcoma which is of clinical importance due to the rapid advances being made in the immunotherapy field.</span></span></p> </div> </div> </div> </div> </div> <div class="col-md-7"> <div class="sidebar-wrapper"> <div class="sidebar sidebar-plain"> <div class="core-style"> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/what-sarcoma" target="_self" aria-label="What is sarcoma?"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/2116/0630/6586/Icon1.png" alt=""> </div> <div class="box-title"> <p>What is sarcoma?</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/diagnosing-sarcoma" target="_self" aria-label="Diagnosing sarcoma"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/9516/0630/6596/LSdiag.png" alt=""> </div> <div class="box-title"> <p>Diagnosing sarcoma</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/treating-sarcoma" target="_self" aria-label="Treating sarcoma"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/5316/0630/6596/LStreat.png" alt=""> </div> <div class="box-title"> <p>Treating sarcoma</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/rehabilitation-and-support-services" target="_self" aria-label="Rehabilitation"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/2116/0630/6596/LSrehab.png" alt=""> </div> <div class="box-title"> <p>Rehabilitation and support services</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-referrals" target="_self" aria-label="Sarcoma referrals"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/6516/0562/3089/BDrefericon.png" alt=""> </div> <div class="box-title"> <p>Sarcoma referrals</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/our-sarcoma-teams" target="_self" aria-label="Sarcoma teams"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/8316/0630/6596/LSteam.png" alt=""> </div> <div class="box-title"> <p>Meet the sarcoma teams</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-research" target="_self" aria-label="Sarcoma research and innovation"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/9316/0630/6596/LSresearch.png" alt=""> </div> <div class="box-title"> <p>Sarcoma research</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/news" target="_self" aria-label="News"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/2016/0630/6596/LSnewicon.jpg" alt=""> </div> <div class="box-title"> <p>Sarcoma news</p> </div> </div> </a> </div> <div class="box-link-block box-block box-small-icon"> <a class="box-link" href="https://www.uclh.nhs.uk/our-services/find-service/cancer-services/londonsarcomaservice/sarcoma-patients/patient-information/useful-sarcoma-links" target="_self" aria-label="Useful sarcoma links"> <div class="box-content"> <div class="box-image"> <img src="https://www.uclh.nhs.uk/application/files/1416/0596/1506/UsefulLinks.jpg" alt=""> </div> <div class="box-title"> <p>Sarcoma links</p> </div> </div> </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="main__feedback has-sidebar"> <div class="container"> <div class="row"> <div class="col-xs-24"> <div class="core-style"> <p>Was this page helpful? 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GeCIPing Sarcoma : University College London Hospitals NHS Foundation Trust