Eficacia terapandeacute;utica de la L-metioninasa como agent

<!doctype html> <html lang="es"> <head> <title>Eficacia terapandeacute;utica de la L-metioninasa como agent | 106788</title> <meta name="keywords" content="Bhawana Kharayat, Priyanka Singh* , "/> <meta name="description" content="La L-metioninasa tiene una aplicación importante como fármaco anticancerígeno quimioterapéutico en el sector farmacéutic..106788"/> <meta name="citation_publisher" content="Longdom Publicaci贸n SL" /> <meta name="citation_journal_title" content="Ingenier铆a enzim谩tica"> <meta name="citation_title" content="Eficacia terapandeacute;utica de la L-metioninasa como agente anticancerandiacute;geno: anandaacute;lisis in silico versus in vivo "> <meta name="citation_author" content="Bhawana Kharayat" /> <meta name="citation_author" content="Priyanka Singh" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="13"> <meta name="citation_issue" content="1"> <meta name="citation_abstract" content="La L-metioninasa tiene una aplicación importante como fármaco anticancerígeno quimioterapéutico en el sector farmacéutico. La actividad catalítica de la L-metioninasa ha agotado el suministro exógeno de L-metionina al detener el crecimiento de las células cancerosas dependientes de metionina. En este estudio, la L-metioninasa se purificó a partir de caldo fermentado de un nuevo aislado bacteriano Pseudomonas stutzeri MTCC 101 con peso molecular (45 kDa), constante de Michaelis (K m = 36,5 mM) y actividad máxima (V max = 500 μmol/min/mg de proteína). Esta enzima se resolvió en 291 secuencias de péptidos después de la espectroscopia MALDI-TOF/MS. Los estudios de acoplamiento molecular y simulación como enfoque in silico habían confirmado su mayor afinidad de unión hacia los sustratos L-treonina y L-metionina. La prueba de especificidad del sustrato había confirmado su actividad máxima para el sustrato de aminoácido específico L-metionina. La alta estabilidad conformacional de su modelo tridimensional con el sustrato L-metionina se validó realizando un análisis in vitro contra líneas celulares cancerosas. Los experimentos se validaron realizando un análisis in vitro de esta enzima contra el crecimiento de líneas celulares cancerosas. Esta enzima purificada mostró un buen efecto inhibidor contra el cáncer hepatocelular (Hep-G2) y el carcinoma pulmonar humano (A549) con un valor de CI50 de 56 μg/ml y 53 μg/ml respectivamente. Esta enzima podría usarse de manera efectiva para la formulación de fármacos terapéuticos contra el cáncer en el futuro. 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nav-link" href="https://spanish.longdom.org/chemistry-journals.html" title="haga clic aqu铆">Qu铆mica</a><br> </nav> </div> </div>  </aside> <div class="col-12 col-sm-9"> <h2 class="heading-1">abstracto</h2> <h3 class="">Eficacia terapéutica de la L-metioninasa como agente anticancerígeno: análisis in silico versus in vivo </h3> <p> <i class="fas fa-user"></i> Bhawana Kharayat, Priyanka Singh* </p> <p>La L-metioninasa tiene una aplicación importante como fármaco anticancerígeno quimioterapéutico en el sector farmacéutico. La actividad catalítica de la L-metioninasa ha agotado el suministro exógeno de L-metionina al detener el crecimiento de las células cancerosas dependientes de metionina. En este estudio, la L-metioninasa se purificó a partir de caldo fermentado de un nuevo aislado bacteriano Pseudomonas stutzeri MTCC 101 con peso molecular (45 kDa), constante de Michaelis (K <sub>m</sub> = 36,5 mM) y actividad máxima (V <sub>max</sub> = 500 μmol/min/mg de proteína). Esta enzima se resolvió en 291 secuencias de péptidos después de la espectroscopia MALDI-TOF/MS. Los estudios de acoplamiento molecular y simulación como enfoque in silico habían confirmado su mayor afinidad de unión hacia los sustratos L-treonina y L-metionina. La prueba de especificidad del sustrato había confirmado su actividad máxima para el sustrato de aminoácido específico L-metionina. La alta estabilidad conformacional de su modelo tridimensional con el sustrato L-metionina se validó realizando un análisis in vitro contra líneas celulares cancerosas. Los experimentos se validaron realizando un análisis in vitro de esta enzima contra el crecimiento de líneas celulares cancerosas. Esta enzima purificada mostró un buen efecto inhibidor contra el cáncer hepatocelular (Hep-G2) y el carcinoma pulmonar humano (A549) con un valor de CI50 <sub>de</sub> 56 μg/ml y 53 μg/ml respectivamente. Esta enzima podría usarse de manera efectiva para la formulación de fármacos terapéuticos contra el cáncer en el futuro.</p> <div class="alert alert-info text-left"><b>Descargo de responsabilidad:</b> este resumen se tradujo utilizando herramientas de inteligencia artificial y a煤n no ha sido revisado ni verificado.</div> <div class="nav social-icons"> <a class="nav-link w-auto">Comparte este art铆culo</a> <a title="haga clic aqu铆" target="_blank" href="https://www.facebook.com/sharer.php?u=https://spanish.longdom.org/abstract/therapeutic-effectiveness-of-lmethioninase-as-anticancer-agent-in-silico-versus-in-vivo-analysis-106788.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="haga clic aqu铆" target="_blank" href="https://twitter.com/share?url=https://spanish.longdom.org/abstract/therapeutic-effectiveness-of-lmethioninase-as-anticancer-agent-in-silico-versus-in-vivo-analysis-106788.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="haga clic aqu铆" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://spanish.longdom.org/abstract/therapeutic-effectiveness-of-lmethioninase-as-anticancer-agent-in-silico-versus-in-vivo-analysis-106788.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="haga clic aqu铆" target="_blank" href="https://plus.google.com/share?url=https://spanish.longdom.org/abstract/therapeutic-effectiveness-of-lmethioninase-as-anticancer-agent-in-silico-versus-in-vivo-analysis-106788.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Enlaces de contenido</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://spanish.longdom.org/privacy-policy.html" title="haga clic aqu铆">Pol铆tica de Privacidad</a></li> <li><a class="" href="https://spanish.longdom.org/terms-conditions.html" title="haga clic aqu铆">T茅rminos y condiciones Condiciones</a></li> <li><a class="" href="https://spanish.longdom.org/authors-reviewers-editors.html" title="haga clic aqu铆">Autores, revisores y editor</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Contacto Longdom</h4> <p><font style="vertical-align:inherit"><font style="vertical-align:inherit">Longdom Group SA </font></font><br /> <font style="vertical-align:inherit"><font style="vertical-align:inherit">Avenue Roger Vandendriessche, </font></font><br /> <font style="vertical-align:inherit"><font style="vertical-align:inherit">18, 1150 Bruselas, Bélgica </font></font><br /> <font style="vertical-align:inherit"><font style="vertical-align:inherit">Teléfono: +442038085340 </font></font><br /> <strong><font style="vertical-align:inherit"><font style="vertical-align:inherit">Correo electrónico: </font></font></strong> <a class="white" href="mailto:info@longdom.org" title="haga clic aqu铆"><font style="vertical-align:inherit"><font style="vertical-align:inherit">info@longdom.org</font></font></a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Conectar</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="haga clic aqu铆" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i></a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="haga clic aqu铆" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i></a> <a href="https://twitter.com/LongdomP" title="haga clic aqu铆" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i></a> <a href="https://www.instagram.com/longdom_publisher/" title="haga clic aqu铆" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i></a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>derechos de autor © 2024 <a href="https://spanish.longdom.org/" title="haga clic aqu铆" class="white">Longdom Publicaci贸n SL</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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Eficacia terapandeacute;utica de la L-metioninasa como agent | 106788