CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '91338d4cafe99c4d',cH: 'tAxheJPY5bUgOq1lr5Onc0Nu60FcoyzVIjYzH91vqJ8-1739771972-1.2.1.1-ZqVk7xMRcfymBBpa3hCmg0KG9RxT644Td.ixXbN1VyheW_eAteRKafIfDtlX7OWA',cUPMDTk: "\/doi\/10.1021\/ac1001492?__cf_chl_tk=VxDRvm.P1JAgHGtNnpIHsdk4SOBsCRBbrLQ7MzpV9pQ-1739771972-1.0.1.1-LzAt.o2RI8akxPWI79nlJE.lgWFdiTrzEkKyRSVm8mQ",cFPWv: 'b',cITimeS: '1739771972',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1021\/ac1001492?__cf_chl_f_tk=VxDRvm.P1JAgHGtNnpIHsdk4SOBsCRBbrLQ7MzpV9pQ-1739771972-1.0.1.1-LzAt.o2RI8akxPWI79nlJE.lgWFdiTrzEkKyRSVm8mQ",md: "fVT_gPdnttRcztZ84z6iK7acT7VKnpW_Q6DBjJkvHag-1739771972-1.2.1.1-h4e1yBMHRUdJuyVjmwauAI1brSgSCipRG6_tyI.jaNFNOk30g2kEIFpjiR5FdFAbHMVWKo.7gNMwDLp7icuh4p4Aofbms8qEwrA8nWFFqxU6FKX1QPFfIjP9zft8uQBE9O7TC8CEbOiJ2b389WRkyNwLfL1BTpLxSu6TPOULqMRIGfUZeoXs9Ar1T5BnVY1Se4NJw4iZEJ6MNDbp9w95Pyx47ohU2Qp4zD9zT.nr9fOjN.2qfOLQMjktZsr48AaZw85fymsgr3zV1gl0RZQMVUr01zZ2YkHSYzrexDOMruzzEJp3xCo9wfmmAzQvrlmpkNZcVn7JiOc1paD6EP2CjoDeOxKNGfWk4HssHisc_i1n_gu9h6uWlYWpM67kGVtHpk8MeckOsuBy5cAXsQ12TYfehPMAq5Gj09o30pdD84skuelCyjw3yVonrc6lNJVJ_zuHKpoBMxBqv1cfEFUeFBGGznxRuY7w.uLmpl8795e10FEViCsnGNcQE8QFr0xZNng0nIEeB9a5ExSbzDrQWJs5zOQuxc4IIBxZkI2XPNRTcZI3HIDFZq4WfSjVRhDCdCyiXEacF__4LDuzlI043vvv3os4.FgC6nS3TshRLM21RIBPfKfuWi6ug8ZUrBKRR417vPUm3TGLQCe5utmXq6nRVa7W0xH_dXUy1FN9QDjxV2bEFVvwtkmo08t3Ulh.Rx0d4Ps9wsd_rgyJ05xrU77gn4sGIThcTbXOdKVxGbxXqVyAJr28rAAXHVxyKSJm0SJ3T8uy5brToUkWkTjRKZaidkPl32CvR2RxRL6jf9IESGWGAqnBNZZtTXeXcjWTfGMRtbv41yzXVgOsf5VyAGekPPZ1QU6C4c11LokxarnmVhLZX3qv4GXGFq6Az.Q6hl5d.OvqGZ3g9_vymogyai5GEk8nfxm6BVXDxokCwInZdNycUxSeZM5TDC0qlkjmb_pXEcFrF2Spp.GoFUMs3_EOKSQvcMRPgWWHQ97dqDgjswYDit5MsnkO1sfEYaMC.af9S_T1ZrkJMo8FZY.VBi5g7DcJJEJKtHqA8Wl5xe.XL2RGUjzsQ_muxaccayQCIJKzATDozeHyl3EFPwg04mXiRHdjem75OyPeFyab4YEN3bN1Iw5SfHr8grM31HCLRYbLp90p7sNdNoMBylmBIwZvuJOhHvFphHu38Xa6_7IGX5y_z_DLA.epgAI0mLVcLcJFgQJ1DAGmf01TMWizN92.gVdk7Z9Woq04ro46WVEkRUeu2jBmgiLAe9lDTYacosQ2M8BgZDC.E1vpTki6hhOSL2cTgX72WvZPdvKFXNG9klXI_XEiV7xCZmCCtIXt8eG1DMHhgoF_v59p83LJHoXY8VK7aiJ.yfeOpD5IezIVHcA3r7eHKCmhv.8AQShYw4CpCDWBmKtR5y426aJgEHwULABYfxGmH_ujVe2C5LGwrShSH99aOG9BTTF5AW5gStpB.Fvz6FY0XiUvfq.aAHsClzxNqx18E3ixaLJgHraWavTf2opvI4x.hvNvca6lm6wmFFmHtkS.afWe7Zv_CGwh5yWKFs0oMsgDr6p0YgIddyeJZWJZZvX6ksXK5vLanZ8jG8i3S13.0PvgR_yFGV7cEeeU1Qgm3nL3l.HUvD0djx8q2eS2K1Ut9ZSkeRFMhyCac1AZAql3LJZEwHL4CqOcxnBoLKdE2JHNqVQZwFSDmpaVlaSifOmTQeGSFPVsMZESFcfkREBhV8GCyynYrFyInIvd.GrNTrJmZFbU3DOjuRBjFLmIPsDnH1Wwe4NXXrpoV9GL5izh_MWNmgQN9_2xbPzwt.XZYgWZDHkehWIg_rRlvcApp9seWNOukC0SZwc4yLyeV3NCBn2XNcX1MguYuey7wOFSNBP_hXxcbJnjmGAYjcbul.B9qj1M49kej76FKHKY0I5ZuoRbvST7_0Rz.1gqa3p4gfFMAixdtxN8NligMx.CSzEHGCzI9y4iWy7oy.kLaeqp3FIObUK.QNSQAg_7QPIoWnKSPtUWuqfYYLGFiJnhtoLixyUBX.J6DhY44qZ6yuSxuqWh_SzP5o0h1g.gh2zbbShrM6ozqqlfJJ6xBUe4R5toqx0GDyoyRELBiTO9VR2N0ESvwIpJu.YWxPvFh_YMSY230jnPhidNDZnuIBeUezS7wOwOUAhmtBa1QTNolVTIfJtUM75rMTzYjifvwb.Z_fN9hBX5dHqsW7ueWPydM8YIUcqr5Mtd1Uvb4tCpolKIStclTWjBxYrE.HSu_C9uVq9G3mGxMSTWBegVs2MQQlKPBgh3ILSrn09v1zQynMvGmCuMymRN.b0I12jGDeI9l0xXvmMeGvb5Qj6b6puiISr.xnlJVY8DQU8sbnnZPKV3n7DCyJH37BJn3iqsZ.l9fDvfqy7xXfUDW_nrAxe_NExqcbL_y4cnttjgqOcOsHRr505fGA5pnOtL_6DxzPxd_IuUQgRblq1bLMxAZESFpDd9TTbidrtcYP.DHgUfYEZKb2LeY6y3dWAeeatEmjRLksPxoUU03v8lpKUtR7Hlr5tF0WxCyjed",mdrd: "QakbY9NyP7EpTtA6KvuuF3BD6WvfAPQZpd8clVbcBaY-1739771972-1.2.1.1-4wwhjXjfusD5Ai8rA8deW3aiZRmYgFZ3RGMFxOLUbeA3psnzNM17hzge4q7VamDls7weNLRZk_4kgP_kK7wiDoxE2PRtU79v0KEhfWlc7jI.tIOClnNF2lHNWgweaeFzNOZDJpJPFhC5Ne6L37qynPAVoqcG4fzxXC.9IHT28PJY.MGzQyDDZKyFheZifVOPXFz29IZcslc5fRKX1XiCuP1_QPWG2Gc3OvFQwRFWZULFX4WXViSJOqe.9ghnwmqB2ngFxTIaoQfw1xoDCozIgJfCQCNpCeDlsaRbO.puB_Wrx8yj6n21CqxRvdNjmAvH9baDRAyPs9M6xB1.SARNM7OJ_2qBqg0jcl7Ud4QwVhuefg3Vji3YOwceWipdtCTVSSJnnnlBSdl0boXDFRJ6aztkgNtDq1UwZd2ypmqrBIz19FYgCpRi1tmHCmcvxAT7OihHZ_9ODc3uWKFYUxoQ1hGaagRTV2Hxd1sh5ePO_53o5wO9Epfg36l_3VxyaOOp8sUPTssA4sI7IFruUgNdOcms4j0nc4RT7fDicW0qve8qVhb_lmMEK2JjdIW5KVLaBPr_hfApzhnQah2cevUto60uYMDBP6x07ZD5ovRJnMLcKQzGDkIqeetdaYQdstku9w.ebZMy6kheJ04N_pc1anr0g_6XlMyMd_.1dOunQ8anmNKV_0UbLqJlfSDdfkqR1mK7WoPwv7KHfq5Y3ldPg2F1mHpX2JZApSjcJIMpwafbEQYu.YCJaZPHbKzqJ_XdVrn587GqDiZstDbuNDvay5uZHF8FkCYPB0v_BbJFNIW_25x8DdN6RQvd.mvKOag6ZWg6tPsc_facgC4C3BxgkHNG_Bd44LqsuKSwFHPqdhj2aFby24guoEvnkFzQIEBWxh_x2q1Znh1EmS_hABIa2fuDFMcjtUbnolhxXlSFK3H7sPujcgWVGPQmDXTF4HC0p7nRmlV61q96oT26DdNaKPYpfeM3yF_.0CVY1THJiUBkEhFmptYs82ERhjD8KBoqsKeCmC4Vkp1K0cuXKgRaN9QxkvMEg6uSWX1EcRvwMSoDiNW8zvDpgNRkTu9rJw19VCP5er8vtPOXn7On7xlHXp69dzl6siZCHwvvoGCT.GF.WwmBwKWeyrOaNc5Q607q9PEWZoXdjd.r4t2EuTfmOoMGatLDkXzRIbfd5dr6MRGOCFxQmtx8gE5m6VPko0njwqv8BJgCOwu5RdWB_0SAWWxF8KvWERdrvPZPejTmCNG1AfinWbq7nqrLSwveSk84AT70ASzDwegGC.wPWZ5x794Ni2.DvrQI2yrNrZ2tEB_SreuaDvkIfB1JqIdPLEZanSDmBo33ik21l.wtBgn8RjNRNL1D2Vp_g66oclvCTsYmIdhvk006ndgMXPXkDJ.d3ztxN0_G8.E4tkZSzv5ttXmzUayTvVPkv_evdwbYBsC0NkkOjYHASStQ42h9JJ2TrOPMPYWthO6P__b.Id4IaP6vUsbvLkUF3YQF8KKXPgwG8zb1HHx4R0UHmCLj5DTMbXe6WZteE2rWw35TmXyv6RUvmLxw6j3nUPr8L6BBNG5lDaLc2r0q4PyzQbKkXTnXzYbBFEX9CoML9XjKHbkHxDTlV6OHUwrCmQb48cBMdpvtryUg5WTRo1R7JGZz2ToWjKrlqOKsS6OuZhd5L8HceWw.5IeA1V0RfCEwP0nQF.1Fn5QYEqiz5oF4ZeHRihKu8FsTJFEYvtyiDCyQE7.wI7zEGl53FZ77zbTm_UsesZ8SGL9vFdHps_QCFnMbDo_eBT0PTmSMev4b7TSlsbJVcLmikOUlgTskx.olxx042llW09Sqo3Suz5oLXuFEEHcLSSM2IzDpa6hyvE8tiCkynN.V31tdSHA7wwrLtjSl2QrvYkMxMob53PlyJxgYfTthV_.OJaQLAn21CP11gOb6yvmhwHkZqmyYZkF_0j7PZQc"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=91338d4cafe99c4d';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1021\/ac1001492?__cf_chl_rt_tk=VxDRvm.P1JAgHGtNnpIHsdk4SOBsCRBbrLQ7MzpV9pQ-1739771972-1.0.1.1-LzAt.o2RI8akxPWI79nlJE.lgWFdiTrzEkKyRSVm8mQ" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>