Pseudomonal Bacteremia and Cefepime-Induced Neurotoxicity: A

<!DOCTYPE html> <html lang="fr"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <title>Pseudomonal Bacteremia and Cefepime-Induced Neurotoxicity: A | 127879</title> <meta name="keywords" content="Megan Smith, Chris Mehdizadeh, Avrodet Mourkus, Saad Ansari A, "/> <meta name="description" content="Cefepime is a broad-spectrum fourth-generation cephalosporin with activity against both gram positive and negative bacteria, including Pseudomonas aerugino..127879"/> <meta name="citation_publisher" content="OMICS International" /> <meta name="citation_journal_title" content="Toxicologie : accès libre"> <meta name="citation_title" content="Pseudomonal Bacteremia and Cefepime-Induced Neurotoxicity: A Case Report"> <meta name="citation_author" content="Megan Smith" /> <meta name="citation_author" content="Chris Mehdizadeh" /> <meta name="citation_author" content="Avrodet Mourkus" /> <meta name="citation_author" content="Saad Ansari A" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="9"> <meta name="citation_issue" content="6"> <meta name="citation_abstract" content="Cefepime is a broad-spectrum fourth-generation cephalosporin with activity against both gram positive and negative bacteria, including Pseudomonas aeruginosa [1]. Cefepime is most commonly used for urinary tract infections, soft tissue infections, and febrile neutropenia [2]. Up to 15% of ICU patients on cefepime may experience cefepime-induced neurotoxicity, with risk factors including renal dysfunction, excessive dosage, elevated serum cefepime concentrations, and history of prior brain injury [3]. The adverse effects of cefepime-induced neurotoxicity including encephalopathy, seizures, and coma can be resolved with drug cessation, antiepileptics, or hemodialysis [3]. Here, we present the case of cefepime induced neurotoxicity in a 59-year-old female patient with long-term cefepime antibiotic prescription for Pseudomonal endocarditis and bacteremia with multiple risk factors for reduced renal function. We discuss the relevant risk factors and preventive measures that may have prevented her from developing encephalopathy, as well as the importance of early recognition and prevention of cefepime-induced neurotoxicity in patient care."> <meta name="citation_abstract_html_url" content="https://french.omicsonline.org/abstract/pseudomonal-bacteremia-and-cefepimeinduced-neurotoxicity-a-case-report-127879.html"> <link rel="shortcut icon" href="https://french.omicsonline.org/assets/images/favicon.ico"/> <meta http-equiv="Content-Language" content="fr"> <link rel="canonical" href="https://french.omicsonline.org/peer-reviewed/pseudomonal-bacteremia-and-cefepimeinduced-neurotoxicity-a-case-report-127879.html"> <meta name="google-site-verification" content="qN-HrL2WXoaG2H19_JlH51p2Wb35uW3rvhvy4fVnXnE" /> <link rel="alternate" href="https://french.omicsonline.org/peer-reviewed/pseudomonal-bacteremia-and-cefepimeinduced-neurotoxicity-a-case-report-127879.html" hreflang="fr-FR"/> <link 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Cefepime is most commonly used for urinary tract infections, soft tissue infections, and febrile neutropenia [2]. Up to 15% of ICU patients on cefepime may experience cefepime-induced neurotoxicity, with risk factors including renal dysfunction, excessive dosage, elevated serum cefepime concentrations, and history of prior brain injury [3].</p> <p>The adverse effects of cefepime-induced neurotoxicity including encephalopathy, seizures, and coma can be resolved with drug cessation, antiepileptics, or hemodialysis [3]. Here, we present the case of cefepime induced neurotoxicity in a 59-year-old female patient with long-term cefepime antibiotic prescription for Pseudomonal endocarditis and bacteremia with multiple risk factors for reduced renal function. We discuss the relevant risk factors and preventive measures that may have prevented her from developing encephalopathy, as well as the importance of early recognition and prevention of cefepime-induced neurotoxicity in patient care.</p></p> <div class="alert alert-info text-left"><b>Avertissement:</b> Ce r茅sum茅 a 茅t茅 traduit 脿 l'aide d'outils d'intelligence artificielle et n'a pas encore 茅t茅 examin茅 ni v茅rifi茅.</div> <div class="nav social-icons align-items-center"> <p class="m-0"> Partager cette page:</p> <a class="nav-link" title="Cliquez ici" target="_blank" rel="noopener" href="https://www.facebook.com/sharer.php?u=https://french.omicsonline.org/abstract/pseudomonal-bacteremia-and-cefepimeinduced-neurotoxicity-a-case-report-127879.html"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="Cliquez ici" target="_blank" rel="noopener" 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Pseudomonal Bacteremia and Cefepime-Induced Neurotoxicity: A | 127879