Research advancement in cancer |

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font-size-2 text-warning w-75">Research Article</p> <span class="w-25 ml-4 text-right"> Pages: 1 - 8 </span> </div> <h3 class="font-size-4 w-75 mb-1"> <a href="https://www.hilarispublisher.com/open-access/analysis-of-the-clinical-management-and-quality-of-life-of-frail-patients-with-cancer-and-breakthrough-cancer-pain-in-clinical-pra-91230.html" title="Analysis of the Clinical Management and Quality of Life of frail Patient’s with Cancer and Breakthrough Cancer Pain in Clinical Practice">Analysis of the Clinical Management and Quality of Life of frail Patient’s with Cancer and Breakthrough Cancer Pain in Clinical Practice</a> </h3> <p class="mb-1 font-size-3 text-muted"> <i class="fas fa-user"></i> <a href='https://www.hilarispublisher.com/author/gemma-soler-gonzaacutelez-24942' style='color:#555; border-bottom:1px dotted #CCC;' title='Gemma Soler González'>Gemma Soler González</a>, <a href='https://www.hilarispublisher.com/author/juan-peacuterez-cajaraville-24943' style='color:#555; border-bottom:1px dotted #CCC;' title='Juan Pérez Cajaraville'>Juan Pérez Cajaraville</a>, <a href='https://www.hilarispublisher.com/author/silvia-forcano-sanjuan-24944' style='color:#555; border-bottom:1px dotted #CCC;' title='Silvia Forcano Sanjuan'>Silvia Forcano Sanjuan</a>, <a href='https://www.hilarispublisher.com/author/joseacute-luis-firvida-peacuterez-24945' style='color:#555; border-bottom:1px dotted #CCC;' title='José Luis Firvida Pérez'>José Luis Firvida Pérez</a>, <a href='https://www.hilarispublisher.com/author/ceacutesar-margarit-ferri-24946' style='color:#555; border-bottom:1px dotted #CCC;' title='César Margarit Ferri'>César Margarit Ferri</a>, <a href='https://www.hilarispublisher.com/author/natividad-martiacutenez-banaclocha-24947' style='color:#555; border-bottom:1px dotted #CCC;' title='Natividad Martínez Banaclocha'>Natividad Martínez Banaclocha</a>, <a href='https://www.hilarispublisher.com/author/antonio-javier-jimeacutenez-loacutepez-24948' style='color:#555; border-bottom:1px dotted #CCC;' title='Antonio Javier Jiménez López'>Antonio Javier Jiménez López</a>, <a href='https://www.hilarispublisher.com/author/ana-cabezoacuten-aacutelvarez-24949' style='color:#555; border-bottom:1px dotted #CCC;' title='Ana Cabezón Álvarez'>Ana Cabezón Álvarez</a>, <a href='https://www.hilarispublisher.com/author/ibone-huerta-gonzaacutelez-24950' style='color:#555; border-bottom:1px dotted #CCC;' title='Ibone Huerta González'>Ibone Huerta González</a> and <a href='https://www.hilarispublisher.com/author/begontildea-soler-loacutepez-24951' style='color:#555; border-bottom:1px dotted #CCC;' title='Begoña Soler López'>Begoña Soler López</a>* </p> <p class="mb-2 font-size-3">DOI: <p class="mb-1 font-size-3 text-muted">DOI: <a href="https://www.hilarispublisher.com/open-access/analysis-of-the-clinical-management-and-quality-of-life-of-frail-patients-with-cancer-and-breakthrough-cancer-pain-in-clinical-pra-91230.html" title="Click here">10.37421/1948-5956.2022.S8.011</a></p> </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract91230" role="button" aria-expanded="false" aria-controls="collapseAbstract"> Preview Abstract </a> </div> <div class="col-12 col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://www.hilarispublisher.com/abstract/analysis-of-the-clinical-management-and-quality-of-life-of-frail-patientrsquos-with-cancer-and-breakthrough-cancer-pain--91230.html" title="Abstract" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> Abstract</a> <a href="https://www.hilarispublisher.com/open-access/analysis-of-the-clinical-management-and-quality-of-life-of-frail-patients-with-cancer-and-breakthrough-cancer-pain-in-clinical-pra-91230.html" title="HTML" class="nav-link"><i class="fas fa-file-code fa-lg"></i> Full-Text</a> <a href="https://www.hilarispublisher.com/open-access/analysis-of-the-clinical-management-and-quality-of-life-of-frail-patients-with-cancer-and-breakthrough-cancer-pain-in-cl.pdf" title="PDF" class="card-link border-bottom-2 border-blue-900"><i class="fas fa-file-pdf fa-lg"></i> PDF</a> </nav> </div> <div class="col-12 col-sm-auto"> <div class="d-flex align-items-center"> Share this article <nav class="nav a-px-2"> <a href="https://www.facebook.com/sharer.php?u=https://www.hilarispublisher.com/open-access/analysis-of-the-clinical-management-and-quality-of-life-of-frail-patients-with-cancer-and-breakthrough-cancer-pain-in-clinical-pra-91230.html" class="nav-link" target="_blank"><i class="fab fa-facebook-f facebook"></i></a> <a href="https://twitter.com/share?url=https://www.hilarispublisher.com/open-access/analysis-of-the-clinical-management-and-quality-of-life-of-frail-patients-with-cancer-and-breakthrough-cancer-pain-in-clinical-pra-91230.html" class="nav-link" target="_blank"><i class="fab fa-twitter twitter"></i></a> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.hilarispublisher.com/open-access/analysis-of-the-clinical-management-and-quality-of-life-of-frail-patients-with-cancer-and-breakthrough-cancer-pain-in-clinical-pra-91230.html" class="nav-link" target="_blank"><i class="fab fa-linkedin-in linkedin"></i></a> <a href="https://pinterest.com/pin/create/button/?url=https://www.hilarispublisher.com/open-access/analysis-of-the-clinical-management-and-quality-of-life-of-frail-patients-with-cancer-and-breakthrough-cancer-pain-in-clinical-pra-91230.html" class="nav-link" target="_blank"><i class="fab fa-pinterest-p pinterest"></i></a> <a href="https://www.blogger.com/blog-this.g?u=https://www.hilarispublisher.com/open-access/analysis-of-the-clinical-management-and-quality-of-life-of-frail-patients-with-cancer-and-breakthrough-cancer-pain-in-clinical-pra-91230.html" class="nav-link" target="_blank"><i class="fab fa-blogger-b blogger"></i></a> </nav> </div> </div> </div> <div class="collapse" id="collapseAbstract91230"> <div class="card card-body p-2 bg-light"><p><strong>Purpose: </strong>The purpose of this study was to analyse the clinical management and Quality of Life (QoL) of frail patients with cancer, chronic background pain and Breakthrough Cancer Pain (BTcP) and to assess whether treatment was conditioned by their frailty status.</p> <p><strong>Methods:</strong> This was an observational study in adult frail patients with cancer, chronic background pain and BTcP. Outcomes of interest collected include clinical and sociodemographic data, Karnofsky Performance Status, quality of life (EuroQoL-5D-5L), chronic pain and BTcP characteristics, as well as treatments administered for their control.</p> <p><strong>Results:</strong> A total of 222 patients were included with a mean age of 68 years (range 24-91), 60.5% men, with a mean Karnofsky of 63.2%. The number of daily episodes of BTcP was 3.8 (95% CI 3.3-4.3), with a duration of 34.6 minutes (95% CI 28.8-40.3), and 56.8% had a gradual onset. Opioids were administered to 88.3% of patients for the chronic pain, and to 83.8% for BTcP. The treatment's daily doses administered for chronic pain and BTcP did not differ from those usually recommended. QoL was significantly worst in frail patients with cancer than EuroQol-5D-5L healthy age-matched no frail patients and was related to performance status (p<0.001) and to the social-familial status (p=0.045).</p> <p><strong>Conclusion: </strong>BTP in frail patients with cancer presents with more episodes, of a shorter duration and more gradual onset compared to other published references of patients with BTcP. QoL was seriously affected in this group of patients. No relevant differences were seen in the doses or method of administration of treatments for chronic pain and BTP in frail patients with cancer as compared to the standard recommendations for non-frail patients. Our findings support the importance of the frailty assessment in all patients with BTcP.</p></div> </div> </div> <div class="mb-4"> <div class="d-flex w-100 justify-content-between border-bottom-1 mb-1"> <p class="mb-1 font-size-2 text-warning w-75">Research Article</p> <span class="w-25 ml-4 text-right"> Pages: 1 - 7 </span> </div> <h3 class="font-size-4 w-75 mb-1"> <a href="https://www.hilarispublisher.com/open-access/prostate-cancer-screening-in-hospitalized-patients-results-from-the-nationwide-inpatient-sample-91234.html" title="Prostate Cancer Screening in Hospitalized Patients: Results from the Nationwide Inpatient Sample">Prostate Cancer Screening in Hospitalized Patients: Results from the Nationwide Inpatient Sample</a> </h3> <p class="mb-1 font-size-3 text-muted"> <i class="fas fa-user"></i> <a href='https://www.hilarispublisher.com/author/furqan-b-irfan-24838' style='color:#555; border-bottom:1px dotted #CCC;' title='Furqan B. Irfan'>Furqan B. Irfan</a>*, <a href='https://www.hilarispublisher.com/author/fahad-shabbir-ahmed-24839' style='color:#555; border-bottom:1px dotted #CCC;' title='Fahad Shabbir Ahmed'>Fahad Shabbir Ahmed</a>, <a href='https://www.hilarispublisher.com/author/monica-v-masucci-24840' style='color:#555; border-bottom:1px dotted #CCC;' title='Monica V. Masucci'>Monica V. Masucci</a>, <a href='https://www.hilarispublisher.com/author/angelina-a-cerimele-24843' style='color:#555; border-bottom:1px dotted #CCC;' title='Angelina A. Cerimele'>Angelina A. Cerimele</a>, <a href='https://www.hilarispublisher.com/author/thu-nguyen-24844' style='color:#555; border-bottom:1px dotted #CCC;' title='Thu Nguyen'>Thu Nguyen</a>, <a href='https://www.hilarispublisher.com/author/aryana-sharrak-24845' style='color:#555; border-bottom:1px dotted #CCC;' title='Aryana Sharrak'>Aryana Sharrak</a>, <a href='https://www.hilarispublisher.com/author/david-m-nguyen-24846' style='color:#555; border-bottom:1px dotted #CCC;' title='David M Nguyen'>David M Nguyen</a>, <a href='https://www.hilarispublisher.com/author/tooba-tariq-24849' style='color:#555; border-bottom:1px dotted #CCC;' title='Tooba Tariq'>Tooba Tariq</a>, <a href='https://www.hilarispublisher.com/author/hussein-baydoun-24851' style='color:#555; border-bottom:1px dotted #CCC;' title='Hussein Baydoun'>Hussein Baydoun</a>, <a href='https://www.hilarispublisher.com/author/ahmad-hasan-24855' style='color:#555; border-bottom:1px dotted #CCC;' title='Ahmad Hasan'>Ahmad Hasan</a>, <a href='https://www.hilarispublisher.com/author/mohamed-e-awad-24856' style='color:#555; border-bottom:1px dotted #CCC;' title='Mohamed E Awad'>Mohamed E Awad</a>, <a href='https://www.hilarispublisher.com/author/khaled-saleh-24857' style='color:#555; border-bottom:1px dotted #CCC;' title='Khaled Saleh'>Khaled Saleh</a> and <a href='https://www.hilarispublisher.com/author/patrick-karabon-24858' style='color:#555; border-bottom:1px dotted #CCC;' title='Patrick Karabon'>Patrick Karabon</a> </p> <p class="mb-2 font-size-3">DOI: <p class="mb-1 font-size-3 text-muted">DOI: <a href="https://www.hilarispublisher.com/open-access/prostate-cancer-screening-in-hospitalized-patients-results-from-the-nationwide-inpatient-sample-91234.html" title="Click here">10.37421/1948-5956.2022.14.S8.009</a></p> </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract91234" role="button" aria-expanded="false" aria-controls="collapseAbstract"> Preview Abstract </a> </div> <div class="col-12 col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://www.hilarispublisher.com/abstract/prostate-cancer-screening-in-hospitalized-patients-results-from-the-nationwide-inpatient-sample-91234.html" title="Abstract" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> Abstract</a> <a href="https://www.hilarispublisher.com/open-access/prostate-cancer-screening-in-hospitalized-patients-results-from-the-nationwide-inpatient-sample-91234.html" title="HTML" class="nav-link"><i class="fas fa-file-code fa-lg"></i> Full-Text</a> <a href="https://www.hilarispublisher.com/open-access/prostate-cancer-screening-in-hospitalized-patients-results-from-the-nationwide-inpatient-sample.pdf" title="PDF" class="card-link border-bottom-2 border-blue-900"><i class="fas fa-file-pdf fa-lg"></i> PDF</a> </nav> </div> <div class="col-12 col-sm-auto"> <div class="d-flex align-items-center"> Share this article <nav class="nav a-px-2"> <a href="https://www.facebook.com/sharer.php?u=https://www.hilarispublisher.com/open-access/prostate-cancer-screening-in-hospitalized-patients-results-from-the-nationwide-inpatient-sample-91234.html" class="nav-link" target="_blank"><i class="fab fa-facebook-f facebook"></i></a> <a href="https://twitter.com/share?url=https://www.hilarispublisher.com/open-access/prostate-cancer-screening-in-hospitalized-patients-results-from-the-nationwide-inpatient-sample-91234.html" class="nav-link" target="_blank"><i class="fab fa-twitter twitter"></i></a> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.hilarispublisher.com/open-access/prostate-cancer-screening-in-hospitalized-patients-results-from-the-nationwide-inpatient-sample-91234.html" class="nav-link" target="_blank"><i class="fab fa-linkedin-in linkedin"></i></a> <a href="https://pinterest.com/pin/create/button/?url=https://www.hilarispublisher.com/open-access/prostate-cancer-screening-in-hospitalized-patients-results-from-the-nationwide-inpatient-sample-91234.html" class="nav-link" target="_blank"><i class="fab fa-pinterest-p pinterest"></i></a> <a href="https://www.blogger.com/blog-this.g?u=https://www.hilarispublisher.com/open-access/prostate-cancer-screening-in-hospitalized-patients-results-from-the-nationwide-inpatient-sample-91234.html" class="nav-link" target="_blank"><i class="fab fa-blogger-b blogger"></i></a> </nav> </div> </div> </div> <div class="collapse" id="collapseAbstract91234"> <div class="card card-body p-2 bg-light"><p class="MsoNoSpacing" style="text-align:justify"><span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Verdana,"><b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:">Objective:</span></span></span></b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:"> The aim of the study was to determine the nationwide prevalence, trends, and predictors of inpatient PCa screening in average risk patients using the National Inpatient Sample (NIS) database.</span></span></span></span></span></span></p> <p class="MsoNoSpacing" style="text-align:justify"><span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Verdana,"><b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:">Methods:</span></span></span></b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:"> NIS records from 2006 to 2014 were used to evaluate inpatient PCa screening encounters across United States (US) hospitals. All male patients between the ages of 45 and 69 at average risk for PCa were included. The outcome was whether a patient had an encounter for PCa as noted on their discharge record. Variables analyzed included demographic factors, hospital characteristics, and other concomitant diagnoses for prostatic or urologic problems.</span></span></span></span></span></span></p> <p class="MsoNoSpacing" style="text-align:justify"><span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Verdana,"><b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:">Results:</span></span></span></b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:"> The prevalence of inpatient PCa screening was 2.57 per 100,000 hospital discharges. In a multivariate setting, the following were significant factors associated with greater odds of inpatient screening: Medicare (AOR: 3.07; P=0.0016), self-pay or uninsured patients (AOR: 1.74; P=0.0371), rural (AOR: 11.9; P </span></span></span><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">≤</span></span></span><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:"> 0.0001) or urban nonteaching hospitals (AOR: 5.26; P </span></span></span><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">≤ </span></span></span><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:">0.0001), Midwest hospitals (AOR: 4.90; P </span></span></span><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span cambria="" style="font-family:">≤ </span></span></span><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:">0.0001), urinary tract infection (P=0.0367), genitourinary symptoms (P<0.0001), prostatic hyperplasia (P=0.0006), or other male genital disorder diagnoses (P<0.0001).</span></span></span></span></span></span></p> <p class="MsoNoSpacing" style="text-align:justify"><span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Verdana,"><b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:">Conclusion:</span></span></span></b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:"> In light of unequal access to healthcare, disparities exist in uninsured and rural populations regarding cancer screening. PSA is a minimally invasive test that can help screen individuals at increased risk for the development of prostate cancer, allowing for early detection, prevention, improved rates of cure and ultimately, decreased rates of mortality.</span></span></span></span></span></span></p></div> </div> </div> <div class="mb-4"> <div class="d-flex w-100 justify-content-between border-bottom-1 mb-1"> <p class="mb-1 font-size-2 text-warning w-75">Brief Report</p> <span class="w-25 ml-4 text-right"> Pages: 1 - 3 </span> </div> <h3 class="font-size-4 w-75 mb-1"> <a href="https://www.hilarispublisher.com/open-access/challenges-in-treating-hodgkins-lymphoma-starting-at-the-beginning-91235.html" title="Challenges in treating Hodgkin's Lymphoma: Starting at the Beginning">Challenges in treating Hodgkin's Lymphoma: Starting at the Beginning</a> </h3> <p class="mb-1 font-size-3 text-muted"> <i class="fas fa-user"></i> <a href='https://www.hilarispublisher.com/author/fernanda-lagares-xavier-peres-24866' style='color:#555; border-bottom:1px dotted #CCC;' title='Fernanda Lagares Xavier Peres'>Fernanda Lagares Xavier Peres</a>, <a href='https://www.hilarispublisher.com/author/antocircnia-pardo-chaga-24867' style='color:#555; border-bottom:1px dotted #CCC;' title='Antônia Pardo Chaga'>Antônia Pardo Chaga</a>, <a href='https://www.hilarispublisher.com/author/nataacutelia-dassi-24868' style='color:#555; border-bottom:1px dotted #CCC;' title='Natália Dassi'>Natália Dassi</a>, <a href='https://www.hilarispublisher.com/author/thais-g-almeida-24912' style='color:#555; border-bottom:1px dotted #CCC;' title='Thais G. Almeida'>Thais G. Almeida</a>, <a href='https://www.hilarispublisher.com/author/acircngela-rech-cagol-24913' style='color:#555; border-bottom:1px dotted #CCC;' title='Ângela Rech Cagol'>Ângela Rech Cagol</a>, <a href='https://www.hilarispublisher.com/author/ceciacutelia-fernandes-lorea-24914' style='color:#555; border-bottom:1px dotted #CCC;' title='Cecília Fernandes Lorea'>Cecília Fernandes Lorea</a>, <a href='https://www.hilarispublisher.com/author/pablo-santiago-24915' style='color:#555; border-bottom:1px dotted #CCC;' title='Pablo Santiago'>Pablo Santiago</a>, <a href='https://www.hilarispublisher.com/author/laura-garcia-de-borba-24916' style='color:#555; border-bottom:1px dotted #CCC;' title='Laura Garcia de Borba'>Laura Garcia de Borba</a>, <a href='https://www.hilarispublisher.com/author/liane-esteves-daudt-24917' style='color:#555; border-bottom:1px dotted #CCC;' title='Liane Esteves Daudt'>Liane Esteves Daudt</a> and <a href='https://www.hilarispublisher.com/author/mariana-bohns-michalowski-24919' style='color:#555; border-bottom:1px dotted #CCC;' title='Mariana Bohns Michalowski'>Mariana Bohns Michalowski</a>* </p> <p class="mb-2 font-size-3">DOI: <p class="mb-1 font-size-3 text-muted">DOI: <a href="https://www.hilarispublisher.com/open-access/challenges-in-treating-hodgkins-lymphoma-starting-at-the-beginning-91235.html" title="Click here">10.37421/1948-5956.2022.14.S8.010</a></p> </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract91235" role="button" aria-expanded="false" aria-controls="collapseAbstract"> Preview Abstract </a> </div> <div class="col-12 col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://www.hilarispublisher.com/abstract/challenges-in-treating-hodgkins-lymphoma-starting-at-the-beginning-91235.html" title="Abstract" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> Abstract</a> <a href="https://www.hilarispublisher.com/open-access/challenges-in-treating-hodgkins-lymphoma-starting-at-the-beginning-91235.html" title="HTML" class="nav-link"><i class="fas fa-file-code fa-lg"></i> Full-Text</a> <a href="https://www.hilarispublisher.com/open-access/challenges-in-treating-hodgkins-lymphoma-starting-at-the-beginning.pdf" title="PDF" class="card-link border-bottom-2 border-blue-900"><i class="fas fa-file-pdf fa-lg"></i> PDF</a> </nav> </div> <div class="col-12 col-sm-auto"> <div class="d-flex align-items-center"> Share this article <nav class="nav a-px-2"> <a href="https://www.facebook.com/sharer.php?u=https://www.hilarispublisher.com/open-access/challenges-in-treating-hodgkins-lymphoma-starting-at-the-beginning-91235.html" class="nav-link" target="_blank"><i class="fab fa-facebook-f facebook"></i></a> <a href="https://twitter.com/share?url=https://www.hilarispublisher.com/open-access/challenges-in-treating-hodgkins-lymphoma-starting-at-the-beginning-91235.html" class="nav-link" target="_blank"><i class="fab fa-twitter twitter"></i></a> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.hilarispublisher.com/open-access/challenges-in-treating-hodgkins-lymphoma-starting-at-the-beginning-91235.html" class="nav-link" target="_blank"><i class="fab fa-linkedin-in linkedin"></i></a> <a href="https://pinterest.com/pin/create/button/?url=https://www.hilarispublisher.com/open-access/challenges-in-treating-hodgkins-lymphoma-starting-at-the-beginning-91235.html" class="nav-link" target="_blank"><i class="fab fa-pinterest-p pinterest"></i></a> <a href="https://www.blogger.com/blog-this.g?u=https://www.hilarispublisher.com/open-access/challenges-in-treating-hodgkins-lymphoma-starting-at-the-beginning-91235.html" class="nav-link" target="_blank"><i class="fab fa-blogger-b blogger"></i></a> </nav> </div> </div> </div> <div class="collapse" id="collapseAbstract91235"> <div class="card card-body p-2 bg-light"><p class="MsoNoSpacing" style="text-align:justify"><span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Verdana,"sans-serif""><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Archivo narrow","serif"">Standard of care and protocols for the treatment of pediatric cancer lead to a clear improvement in survival rates and quality of life. Little is known about how these treatments are implemented in Brazil. Our study aimed to evaluate children treated for Hodgkin Disease (HD) in south Brazil between 2002 and 2013 through the analysis of medical records in 6 different centers.</span></span></span></span></span></span></p> <p class="MsoNoSpacing" style="text-align:justify"><span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Verdana,"sans-serif""><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Archivo narrow","serif"">Fifty-nine children and adolescents were included. The median age was 12 years (range 3-18 years). Male:Female ratio was 1.95:1. Localized disease (stage I/II) was observed in 30 patients (50.8%) while the remaining 29 (49.2%) had advanced disease (Stage III/IV).</span></span></span></span></span></span></p> <p class="MsoNoSpacing" style="text-align:justify"><span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Verdana,"sans-serif""><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Archivo narrow","serif"">The chemotherapeutic treatment schema was different among services and comprised three different based protocols. ABVD schema was the most frequently used (52 children (88.1%). The number of cycles was highly variable (4-16 cycles) even at the same clinical stage and with similar clinical response.</span></span></span></span></span></span></p> <p class="MsoNoSpacing" style="text-align:justify"><span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Verdana,"sans-serif""><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Archivo narrow","serif"">These data highlight the importance of turning the “best practice policies” readily available to all pediatric oncologists. Local protocols allow integrative studies among centers that would certainly maintain or improve cure rates, reduce long-term toxicity and evaluate specific biological characteristics of these diseases in our population.</span></span></span></span></span></span></p></div> </div> </div> <div class="mb-4"> <div class="d-flex w-100 justify-content-between border-bottom-1 mb-1"> <p class="mb-1 font-size-2 text-warning w-75">Research Article</p> <span class="w-25 ml-4 text-right"> Pages: 1 - 7 </span> </div> <h3 class="font-size-4 w-75 mb-1"> <a href="https://www.hilarispublisher.com/open-access/impact-of-early-palliative-care-on-end-of-life-in-patients-with-advanced-biliary-tract-cancer-91280.html" title="Impact of Early Palliative Care on end of life in Patients with Advanced Biliary Tract Cancer">Impact of Early Palliative Care on end of life in Patients with Advanced Biliary Tract Cancer</a> </h3> <p class="mb-1 font-size-3 text-muted"> <i class="fas fa-user"></i> <a href='https://www.hilarispublisher.com/author/margaux-miralles-24723' style='color:#555; border-bottom:1px dotted #CCC;' title='Margaux Miralles'>Margaux Miralles</a>, <a href='https://www.hilarispublisher.com/author/marie-muller-24724' style='color:#555; border-bottom:1px dotted #CCC;' title='Marie Muller'>Marie Muller</a>, <a href='https://www.hilarispublisher.com/author/christophe-borg-24725' style='color:#555; border-bottom:1px dotted #CCC;' title='Christophe Borg'>Christophe Borg</a>, <a href='https://www.hilarispublisher.com/author/sylvain-manfredi-24727' style='color:#555; border-bottom:1px dotted #CCC;' title='Sylvain Manfredi'>Sylvain Manfredi</a>, <a href='https://www.hilarispublisher.com/author/anne-minello-24728' style='color:#555; border-bottom:1px dotted #CCC;' title='Anne Minello'>Anne Minello</a>, <a href='https://www.hilarispublisher.com/author/olivier-boucheacute-24729' style='color:#555; border-bottom:1px dotted #CCC;' title='Olivier Bouché'>Olivier Bouché</a>, <a href='https://www.hilarispublisher.com/author/marlegravene-tambou-24730' style='color:#555; border-bottom:1px dotted #CCC;' title='Marlène Tambou'>Marlène Tambou</a>, <a href='https://www.hilarispublisher.com/author/didier-mutter-24731' style='color:#555; border-bottom:1px dotted #CCC;' title='Didier Mutter'>Didier Mutter</a>, <a href='https://www.hilarispublisher.com/author/pascale-chiappa-24732' style='color:#555; border-bottom:1px dotted #CCC;' title='Pascale Chiappa'>Pascale Chiappa</a>, <a href='https://www.hilarispublisher.com/author/jeanemmanuel-kurtz-24733' style='color:#555; border-bottom:1px dotted #CCC;' title='Jean-Emmanuel Kurtz'>Jean-Emmanuel Kurtz</a>, <a href='https://www.hilarispublisher.com/author/amandine-luc-24734' style='color:#555; border-bottom:1px dotted #CCC;' title='Amandine Luc'>Amandine Luc</a> and <a href='https://www.hilarispublisher.com/author/anthony-lopez-24735' style='color:#555; border-bottom:1px dotted #CCC;' title='Anthony Lopez'>Anthony Lopez</a>* </p> <p class="mb-2 font-size-3">DOI: <p class="mb-1 font-size-3 text-muted">DOI: <a href="https://www.hilarispublisher.com/open-access/impact-of-early-palliative-care-on-end-of-life-in-patients-with-advanced-biliary-tract-cancer-91280.html" title="Click here">10.37421/1948-5956.2022.S8.007</a></p> </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract91280" role="button" aria-expanded="false" aria-controls="collapseAbstract"> Preview Abstract </a> </div> <div class="col-12 col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://www.hilarispublisher.com/abstract/impact-of-early-palliative-care-on-end-of-life-in-patients-with-advanced-biliary-tract-cancer-91280.html" title="Abstract" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> Abstract</a> <a href="https://www.hilarispublisher.com/open-access/impact-of-early-palliative-care-on-end-of-life-in-patients-with-advanced-biliary-tract-cancer-91280.html" title="HTML" class="nav-link"><i class="fas fa-file-code fa-lg"></i> Full-Text</a> <a href="https://www.hilarispublisher.com/open-access/impact-of-early-palliative-care-on-end-of-life-in-patients-with-advanced-biliary-tract-cancer.pdf" title="PDF" class="card-link border-bottom-2 border-blue-900"><i class="fas fa-file-pdf fa-lg"></i> PDF</a> </nav> </div> <div class="col-12 col-sm-auto"> <div class="d-flex align-items-center"> Share this article <nav class="nav a-px-2"> <a href="https://www.facebook.com/sharer.php?u=https://www.hilarispublisher.com/open-access/impact-of-early-palliative-care-on-end-of-life-in-patients-with-advanced-biliary-tract-cancer-91280.html" class="nav-link" target="_blank"><i class="fab fa-facebook-f facebook"></i></a> <a href="https://twitter.com/share?url=https://www.hilarispublisher.com/open-access/impact-of-early-palliative-care-on-end-of-life-in-patients-with-advanced-biliary-tract-cancer-91280.html" class="nav-link" target="_blank"><i class="fab fa-twitter twitter"></i></a> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.hilarispublisher.com/open-access/impact-of-early-palliative-care-on-end-of-life-in-patients-with-advanced-biliary-tract-cancer-91280.html" class="nav-link" target="_blank"><i class="fab fa-linkedin-in linkedin"></i></a> <a href="https://pinterest.com/pin/create/button/?url=https://www.hilarispublisher.com/open-access/impact-of-early-palliative-care-on-end-of-life-in-patients-with-advanced-biliary-tract-cancer-91280.html" class="nav-link" target="_blank"><i class="fab fa-pinterest-p pinterest"></i></a> <a href="https://www.blogger.com/blog-this.g?u=https://www.hilarispublisher.com/open-access/impact-of-early-palliative-care-on-end-of-life-in-patients-with-advanced-biliary-tract-cancer-91280.html" class="nav-link" target="_blank"><i class="fab fa-blogger-b blogger"></i></a> </nav> </div> </div> </div> <div class="collapse" id="collapseAbstract91280"> <div class="card card-body p-2 bg-light"><p class="MsoNoSpacing" style="text-align:justify"><span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Verdana,"><b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:">Background:</span></span></span></b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:"> Most of patient with Biliary Tract Cancer (BTC) has not access to surgery because of Advanced/metastatic disease at diagnosis (aBTC). They receive palliative chemotherapy and/or Palliative Care (PC). We studied if early palliative care referral might influence Overall Survival (OS) and the aggressiveness of end-of-life care.</span></span></span></span></span></span></p> <p class="MsoNoSpacing" style="text-align:justify"><span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Verdana,"><b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:">Participants:</span></span></span></b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:"> We conducted a retrospective multicentric cohort study in patients with non-curative BTC, diagnosed between 2013 and 2019 in 6 hospitals of Eastern France. PC was defined a specialist-delivered palliative care encounter.</span></span></span></span></span></span></p> <p class="MsoNoSpacing" style="text-align:justify"><span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Verdana,"><b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:">Results</span></span></span></b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:">: 200 patients with aBTC were included. 87 (44%) never received PC, 30 (15%) had very early PC (<3 months after aBTC diagnosis), 20 (10%) had an early PC (3-6 months), and 63 (32%) had late PC (>6 months). The median time between referral and death was 0.9 to 1.3 months. OS were 12.4 months (no PC), 3.0 months (PC<3 m), 6.4 months (PC 3-6 m), 16 months (PC>6 m). There was no evidence for survival improvement with early PC. PC tended to reduce chemotherapy near death (37% without PC, 30% with PC<3m, 11% with PC 3-6m, 10% with PC>6m), visits in emergency department (ED) during final month (respectively: 36%, 20 %, 15%, and 7%), intensive care unit hospitalizations (ICU) near death (13%, 0%, 0%, 2%). Place of death seemed to be positively impacted by PC (conventional acute unit, respectively: 73%, 21%, 21%, 25% and ICU or ED: 8%, 0%, 5%, 2%). </span></span></span></span></span></span></p> <p class="MsoNoSpacing" style="text-align:justify"><span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Verdana,"><b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:">Conclusion</span></span></span></b><span lang="EN-US" style="font-size:10.0pt"><span style="line-height:150%"><span archivo="" narrow="" style="font-family:">: Referral to PC remains too late in the support of patients with aBTC. Our practice should evolve: all patients with aBTC should be referred to early PC in palliative care unit after diagnosis to improve the management of end-of-life, symptoms, and family needs.</span></span></span></span></span></span></p></div> </div> </div> <div class="mb-4"> <div class="d-flex w-100 justify-content-between border-bottom-1 mb-1"> <p class="mb-1 font-size-2 text-warning w-75">Case Report</p> <span class="w-25 ml-4 text-right"> Pages: 1 - 3 </span> </div> <h3 class="font-size-4 w-75 mb-1"> <a href="https://www.hilarispublisher.com/open-access/durable-complete-response-to-first-line-treatment-with-avelumab-in-an-elderly-multimorbid-patient-with-advanced-merkel-cell-carcin-91281.html" title="Durable Complete Response to First Line Treatment with Avelumab in an Elderly, Multimorbid Patient with Advanced Merkel Cell Carcinoma: A Case Report">Durable Complete Response to First Line Treatment with Avelumab in an Elderly, Multimorbid Patient with Advanced Merkel Cell Carcinoma: A Case Report</a> </h3> <p class="mb-1 font-size-3 text-muted"> <i class="fas fa-user"></i> <a href='https://www.hilarispublisher.com/author/enrico-sammarco-25006' style='color:#555; border-bottom:1px dotted #CCC;' title='Enrico Sammarco'>Enrico Sammarco</a>*, <a href='https://www.hilarispublisher.com/author/amedeo-nuzzo-25007' style='color:#555; border-bottom:1px dotted #CCC;' title='Amedeo Nuzzo'>Amedeo Nuzzo</a>, <a href='https://www.hilarispublisher.com/author/simona-manacorda-25008' style='color:#555; border-bottom:1px dotted #CCC;' title='Simona Manacorda'>Simona Manacorda</a>, <a href='https://www.hilarispublisher.com/author/fiorella-manfredi-25009' style='color:#555; border-bottom:1px dotted #CCC;' title='Fiorella Manfredi'>Fiorella Manfredi</a>, <a href='https://www.hilarispublisher.com/author/chiara-mercinelli-25010' style='color:#555; border-bottom:1px dotted #CCC;' title='Chiara Mercinelli'>Chiara Mercinelli</a>, <a href='https://www.hilarispublisher.com/author/marco-ferrari-25011' style='color:#555; border-bottom:1px dotted #CCC;' title='Marco Ferrari'>Marco Ferrari</a>, <a href='https://www.hilarispublisher.com/author/giulia-massaro-25012' style='color:#555; border-bottom:1px dotted #CCC;' title='Giulia Massaro'>Giulia Massaro</a>, <a href='https://www.hilarispublisher.com/author/adele-bonato-25013' style='color:#555; border-bottom:1px dotted #CCC;' title='Adele Bonato'>Adele Bonato</a>, <a href='https://www.hilarispublisher.com/author/alessia-salfi-25014' style='color:#555; border-bottom:1px dotted #CCC;' title='Alessia Salfi'>Alessia Salfi</a>, <a href='https://www.hilarispublisher.com/author/debora-serafin-25015' style='color:#555; border-bottom:1px dotted #CCC;' title='Debora Serafin'>Debora Serafin</a>, <a href='https://www.hilarispublisher.com/author/luca-zatteri-luca-25016' style='color:#555; border-bottom:1px dotted #CCC;' title='Luca Zatteri Luca'>Luca Zatteri Luca</a>, <a href='https://www.hilarispublisher.com/author/galli-andrea-antonuzzo-25017' style='color:#555; border-bottom:1px dotted #CCC;' title='Galli Andrea Antonuzzo'>Galli Andrea Antonuzzo</a> and <a href='https://www.hilarispublisher.com/author/gianluca-masi-25018' style='color:#555; border-bottom:1px dotted #CCC;' title='Gianluca Masi'>Gianluca Masi</a> </p> <p class="mb-2 font-size-3">DOI: <p class="mb-1 font-size-3 text-muted">DOI: <a href="https://www.hilarispublisher.com/open-access/durable-complete-response-to-first-line-treatment-with-avelumab-in-an-elderly-multimorbid-patient-with-advanced-merkel-cell-carcin-91281.html" title="Click here">10.37421/1948-5956.2022.14.S8.008</a></p> </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract91281" role="button" aria-expanded="false" aria-controls="collapseAbstract"> Preview Abstract </a> </div> <div class="col-12 col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://www.hilarispublisher.com/abstract/durable-complete-response-to-first-line-treatment-with-avelumab-in-an-elderly-multimorbid-patient-with-advanced-merkel-c-91281.html" title="Abstract" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> Abstract</a> <a href="https://www.hilarispublisher.com/open-access/durable-complete-response-to-first-line-treatment-with-avelumab-in-an-elderly-multimorbid-patient-with-advanced-merkel-cell-carcin-91281.html" title="HTML" class="nav-link"><i class="fas fa-file-code fa-lg"></i> Full-Text</a> <a href="https://www.hilarispublisher.com/open-access/durable-complete-response-to-first-line-treatment-with-avelumab-in-an-elderly-multimorbid-patient-with-advanced-merkel-c.pdf" title="PDF" class="card-link border-bottom-2 border-blue-900"><i class="fas fa-file-pdf fa-lg"></i> PDF</a> </nav> </div> <div class="col-12 col-sm-auto"> <div class="d-flex align-items-center"> Share this article <nav class="nav a-px-2"> <a href="https://www.facebook.com/sharer.php?u=https://www.hilarispublisher.com/open-access/durable-complete-response-to-first-line-treatment-with-avelumab-in-an-elderly-multimorbid-patient-with-advanced-merkel-cell-carcin-91281.html" class="nav-link" target="_blank"><i class="fab fa-facebook-f facebook"></i></a> <a href="https://twitter.com/share?url=https://www.hilarispublisher.com/open-access/durable-complete-response-to-first-line-treatment-with-avelumab-in-an-elderly-multimorbid-patient-with-advanced-merkel-cell-carcin-91281.html" class="nav-link" target="_blank"><i class="fab fa-twitter twitter"></i></a> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.hilarispublisher.com/open-access/durable-complete-response-to-first-line-treatment-with-avelumab-in-an-elderly-multimorbid-patient-with-advanced-merkel-cell-carcin-91281.html" class="nav-link" target="_blank"><i class="fab fa-linkedin-in linkedin"></i></a> <a href="https://pinterest.com/pin/create/button/?url=https://www.hilarispublisher.com/open-access/durable-complete-response-to-first-line-treatment-with-avelumab-in-an-elderly-multimorbid-patient-with-advanced-merkel-cell-carcin-91281.html" class="nav-link" target="_blank"><i class="fab fa-pinterest-p pinterest"></i></a> <a href="https://www.blogger.com/blog-this.g?u=https://www.hilarispublisher.com/open-access/durable-complete-response-to-first-line-treatment-with-avelumab-in-an-elderly-multimorbid-patient-with-advanced-merkel-cell-carcin-91281.html" class="nav-link" target="_blank"><i class="fab fa-blogger-b blogger"></i></a> </nav> </div> </div> </div> <div class="collapse" id="collapseAbstract91281"> <div class="card card-body p-2 bg-light"><p class="MsoBodyTextFirstIndent" style="text-align:justify; text-indent:18pt; margin-top:8px; margin-bottom:8px"><span style="font-size:12pt"><span style="font-family:"Times New Roman","serif""><strong>Introduction:</strong> Metastatic Merkel Cell Carcinoma (MCC) is characterized by poor prognosis and poor response to cytotoxic chemotherapy. Immune Checkpoint Inhibitors (ICIs) were evaluated in several clinical trials, providing interesting results in terms of activity and efficacy, with a generally manageable safety profile. Limited data are available for use of ICIs in patients affected by multiple chronic diseases. We present the case of a patient with several comorbidities treated with Avelumab for advanced MCC, who developed a durable complete response.</span></span></p> <p class="MsoBodyTextFirstIndent" style="text-align:justify; text-indent:18pt; margin-top:8px; margin-bottom:8px"><span style="font-size:12pt"><span style="font-family:"Times New Roman","serif""><strong>Case description:</strong> A 78-year-old woman with several chronic diseases was treated with Avelumab for MCC with lung and subcutaneous metastases, developing radiological complete response after 5 cycles. Treatment was well tolerated and no severe adverse events were observed.</span></span></p> <p class="MsoBodyTextFirstIndent" style="text-align:justify; text-indent:18pt; margin-top:8px; margin-bottom:8px"><span style="font-size:12pt"><span style="font-family:"Times New Roman","serif""><strong>Conclusion:</strong> Our case shows that Avelumab is an active and safe treatment in multimorbid patients with advanced MCC. More consistent data from randomized clinical trials are needed to confirm these results in a large patient population presenting these special features. </span></span></p></div> </div> </div> <div class="mb-4"> <div class="d-flex w-100 justify-content-between border-bottom-1 mb-1"> <p class="mb-1 font-size-2 text-warning w-75">Research Article</p> <span class="w-25 ml-4 text-right"> Pages: 1 - 5 </span> </div> <h3 class="font-size-4 w-75 mb-1"> <a href="https://www.hilarispublisher.com/open-access/liver-inflammation-parameters-in-relation-to-survival-in--patients-with-hepatocellular-carcinoma-tumor-of-differing--siz.pdf" title="Liver Inflammation Parameters in Relation to Survival in Patients with Hepatocellular Carcinoma Tumor of differing Sizes">Liver Inflammation Parameters in Relation to Survival in Patients with Hepatocellular Carcinoma Tumor of differing Sizes</a> </h3> <p class="mb-1 font-size-3 text-muted"> <i class="fas fa-user"></i> <a href='https://www.hilarispublisher.com/author/brian-carr-28340' style='color:#555; border-bottom:1px dotted #CCC;' title='Brian Carr'>Brian Carr</a>*, <a href='https://www.hilarispublisher.com/author/vito-guerra-28341' style='color:#555; border-bottom:1px dotted #CCC;' title='Vito Guerra'>Vito Guerra</a>, <a href='https://www.hilarispublisher.com/author/uumlmit-karao287ullar305ndan-28342' style='color:#555; border-bottom:1px dotted #CCC;' title='Ümit Karaoğullarından'>Ümit Karaoğullarından</a>, <a href='https://www.hilarispublisher.com/author/hikmet-akkiz-28344' style='color:#555; border-bottom:1px dotted #CCC;' title='Hikmet Akkiz'>Hikmet Akkiz</a>, <a href='https://www.hilarispublisher.com/author/volkan-ince-28345' style='color:#555; border-bottom:1px dotted #CCC;' title='Volkan Ince'>Volkan Ince</a>, <a href='https://www.hilarispublisher.com/author/burak-isik-28346' style='color:#555; border-bottom:1px dotted #CCC;' title='Burak Isik'>Burak Isik</a> and <a href='https://www.hilarispublisher.com/author/sezai-yilmaz-28347' style='color:#555; border-bottom:1px dotted #CCC;' title='Sezai Yilmaz'>Sezai Yilmaz</a> </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract93889" role="button" aria-expanded="false" aria-controls="collapseAbstract"> Preview Abstract </a> </div> <div class="col-12 col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://www.hilarispublisher.com/abstract/liver-inflammation-parameters-in-relation-to-survival-in-patients-with-hepatocellular-carcinoma-tumor-of-differing-sizes-93889.html" title="Abstract" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> Abstract</a> <a href="https://www.hilarispublisher.com/open-access/liver-inflammation-parameters-in-relation-to-survival-in--patients-with-hepatocellular-carcinoma-tumor-of-differing--siz.pdf" title="PDF" class="card-link border-bottom-2 border-blue-900"><i class="fas fa-file-pdf fa-lg"></i> PDF</a> </nav> </div> <div class="col-12 col-sm-auto"> <div class="d-flex align-items-center"> Share this article <nav class="nav a-px-2"> <a href="https://www.facebook.com/sharer.php?u=https://www.hilarispublisher.com/open-access/liver-inflammation-parameters-in-relation-to-survival-in--patients-with-hepatocellular-carcinoma-tumor-of-differing--siz.pdf" class="nav-link" target="_blank"><i class="fab fa-facebook-f facebook"></i></a> <a href="https://twitter.com/share?url=https://www.hilarispublisher.com/open-access/liver-inflammation-parameters-in-relation-to-survival-in--patients-with-hepatocellular-carcinoma-tumor-of-differing--siz.pdf" class="nav-link" target="_blank"><i class="fab fa-twitter twitter"></i></a> <a href="https://www.linkedin.com/shareArticle?mini=true&url=https://www.hilarispublisher.com/open-access/liver-inflammation-parameters-in-relation-to-survival-in--patients-with-hepatocellular-carcinoma-tumor-of-differing--siz.pdf" class="nav-link" target="_blank"><i class="fab fa-linkedin-in linkedin"></i></a> <a href="https://pinterest.com/pin/create/button/?url=https://www.hilarispublisher.com/open-access/liver-inflammation-parameters-in-relation-to-survival-in--patients-with-hepatocellular-carcinoma-tumor-of-differing--siz.pdf" class="nav-link" target="_blank"><i class="fab fa-pinterest-p pinterest"></i></a> <a href="https://www.blogger.com/blog-this.g?u=https://www.hilarispublisher.com/open-access/liver-inflammation-parameters-in-relation-to-survival-in--patients-with-hepatocellular-carcinoma-tumor-of-differing--siz.pdf" class="nav-link" target="_blank"><i class="fab fa-blogger-b blogger"></i></a> </nav> </div> </div> </div> <div class="collapse" id="collapseAbstract93889"> <div class="card card-body p-2 bg-light"><p><strong>Introduction: </strong>Survival in patients with Hepatocellular Carcinoma (HCC) has been previously found to be worse with increase in tumor size, but also with increase in inflammation. To examine these issues separately, we aimed to study the influences on survival of various liver inflammation parameters in the whole cohort, and separately in patients with HCCs of defined Maximum Tumor Diameter (MTD).</p> <p><strong>Methods:</strong> A prospectively collected large database of Turkish HCC patients with documented survival was interrogated. Patients had baseline liver function tests and CT scans for tumor characteristics. Liver function and inflammation parameters included blood tests for levels of albumin, AST, GGT, ALKP, CRP, ESR and WBC.</p> <p><strong>Results:</strong> Survival was worse for patients with larger HCCs, including those with low or high serum AFP levels. Highest hazard ratios were found for patients with abnormal blood albumin (low) or AST (high) levels, regardless of AFP status. When patients were separately examined according to tumor size, only albumin and AST were significant for survival in patients with small <3cm tumors; whereas albumin, AST and ALKP were significant in patients with >3cm HCCs. Abnormal albumin or AST levels in different HCC size cohorts significantly related to percent patients with PVT, higher AFP or increased tumor focality, regardless of tumor size.</p> <p><strong>Results:</strong> Survival was worse for patients with larger HCCs, including those with low or high serum AFP levels. Highest hazard ratios were found for patients with abnormal blood albumin (low) or AST (high) levels, regardless of AFP status. When patients were separately examined according to tumor size, only albumin and AST were significant for survival in patients with small <3cm tumors; whereas albumin, AST and ALKP were significant in patients with >3cm HCCs. Abnormal albumin or AST levels in different HCC size cohorts significantly related to percent patients with PVT, higher AFP or increased tumor focality, regardless of tumor size.</p></div> </div> </div> </div> <div class="col-12 col-sm-3">    <div class="mb-3"> <h4><a href="https://www.hilarispublisher.com/cancer-science-therapy/awards-nomination.html" class="btn btn-danger btn-block mb-3 font-size-4">Awards & Nominations</a></h4> <h4><a href="https://www.hilarispublisher.com/cancer-science-therapy-online-visitors-readers-89.html" class="btn btn-danger btn-block mb-3 font-size-4"><i class="fas fa-book-reader"></i> 50+ Million Readerbase</a></h4> <h4>Journal Highlights</h4> <nav class="nav flex-column scrollbar a-pl-0" style="max-height:50vh;"> <a href="https://www.hilarispublisher.com/scholarly/advances-in-alternative-lung-cancer-treatment-journals-articles-ppts-list-2298.html" class="nav-link" title="Advances in Alternative Lung Cancer Treatment"><i class="far 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