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Small decreases in PaO2, produced by forced ventilation of hypoxic gas mixtures, resulted in decreased amplitude of the characteristic negative shift in extracellular potential which accompanies such stimulation and smaller oxidative response of NADH and cytochrome oxidase. When paO 2 fell below 40-50 Torr, stimulation produced reductive rather than oxidative shifts of the mitochondrial respiratory chain components.","publication_date":"1984,,","publication_name":"Brain Research","grobid_abstract_attachment_id":"39754669"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Oxygen insufficiency during hypoxic hypoxia in rat brain cortex","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [32868221]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div 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class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/93871623/Hypoxemia_oxygen_content_and_the_regulation_of_cerebral_blood_flow">Hypoxemia, oxygen content, and the regulation of cerebral blood flow</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="251334834" href="https://independent.academia.edu/RiegerMatt">Matt Rieger</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2016</p><p class="ds-related-work--abstract ds2-5-body-sm">This review highlights the influence of oxygen (O2) availability on cerebral blood flow (CBF). Evidence for reductions in O2content (CaO2) rather than arterial O2tension (PaO2) as the chief regulator of cerebral vasodilation, with deoxyhemoglobin as the primary O2sensor and upstream response effector, is discussed. We review in vitro and in vivo data to summarize the molecular mechanisms underpinning CBF responses during changes in CaO2. We surmise that 1) during hypoxemic hypoxia in healthy humans (e.g., conditions of acute and chronic exposure to normobaric and hypobaric hypoxia), elevations in CBF compensate for reductions in CaO2and thus maintain cerebral O2delivery; 2) evidence from studies implementing iso- and hypervolumic hemodilution, anemia, and polycythemia indicate that CaO2has an independent influence on CBF; however, the increase in CBF does not fully compensate for the lower CaO2during hemodilution, and delivery is reduced; and 3) the mechanisms underpinning CBF regul...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hypoxemia, oxygen content, and the regulation of cerebral blood flow","attachmentId":96488311,"attachmentType":"pdf","work_url":"https://www.academia.edu/93871623/Hypoxemia_oxygen_content_and_the_regulation_of_cerebral_blood_flow","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/93871623/Hypoxemia_oxygen_content_and_the_regulation_of_cerebral_blood_flow"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":39754669,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":39754669,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_39754669" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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