CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>IRHD Journal - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="Hg81JduW6sdfaO2ud/X3d5R0ITNt0Eqk9Y3WVofrWLTJ6WEdGK98rCHeFex1CLmPwFcjcnsW8j6zGRak91kIpA==" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-77f7b87cb1583fc59aa8f94756ebfe913345937eb932042b4077563bebb5fb4b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-1c712297ae3ac71207193b1bae0ecf1aae125886850f62c9c0139dd867630797.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-b2b823dd904da60a48fd1bfa1defd840610c2ff414d3f39ed3af46277ab8df3b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> <meta name="author" content="irhd journal" /> <meta name="description" content="IRHD Journal: 14 Followers, 4 Following, 27 Research papers." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = 'c7ac46e400875c3b13c788ad246730fe5f6b36cc'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":15272,"monthly_visitors":"113 million","monthly_visitor_count":113784677,"monthly_visitor_count_in_millions":113,"user_count":277494680,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1732754577000); window.Aedu.timeDifference = new Date().getTime() - 1732754577000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-296162c7af6fd81dcdd76f1a94f1fad04fb5f647401337d136fe8b68742170b1.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-7734a8b54dedb8fefe75ef934203d0ef41d066c1c5cfa6ba2a13dd7ec8bce449.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-9eaa790b1139e2d88eb4ac931dcbc6d7cea4403a763db5cc5a695dd2eaa34151.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://independent.academia.edu/IRHDJournal" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://medium.com/@academia">Blog</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-533ab26e53b28997c1064a839643ef40d866d497c665279ed26b743aacb62042.js" defer="defer"></script><script>Aedu.rankings = { showPaperRankingsLink: false } $viewedUser = Aedu.User.set_viewed( {"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal","photo":"https://0.academia-photos.com/282244998/130400338/119808755/s65_irhd.journal.png","has_photo":true,"is_analytics_public":false,"interests":[]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/IRHDJournal","location":"/IRHDJournal","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/IRHDJournal","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-4e04385e-3e9a-47d2-9bff-6ac0c091f241"></div> <div id="ProfileCheckPaperUpdate-react-component-4e04385e-3e9a-47d2-9bff-6ac0c091f241"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="IRHD Journal" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/282244998/130400338/119808755/s200_irhd.journal.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">IRHD Journal</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="IRHD" data-follow-user-id="282244998" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="282244998"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">14</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">4</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">4</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by IRHD Journal</h3></div><div class="js-work-strip profile--work_container" data-work-id="121978069"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121978069/Dysregulation_of_Neuronal_Iron_Homeostasis_as_an_Alternative_Unifying_Effect_of_Mutations_Causing_Familial_Alzheimers_Disease"><img alt="Research paper thumbnail of Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease" class="work-thumbnail" src="https://attachments.academia-assets.com/116734018/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121978069/Dysregulation_of_Neuronal_Iron_Homeostasis_as_an_Alternative_Unifying_Effect_of_Mutations_Causing_Familial_Alzheimers_Disease">Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease</a></div><div class="wp-workCard_item"><span>Frontiers in neuroscience</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The overwhelming majority of dominant mutations causing early onset familial Alzheimer&#39;s dise...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The overwhelming majority of dominant mutations causing early onset familial Alzheimer&#39;s disease (EOfAD) occur in only three genes, , and . An effect-in-common of these mutations is alteration of production of the APP-derived peptide, amyloid β (Aβ). It is this key fact that underlies the authority of the Amyloid Hypothesis that has informed Alzheimer&#39;s disease research for over two decades. Any challenge to this authority must offer an alternative explanation for the relationship between the genes and . In this paper, we explore one possible alternative relationship - the dysregulation of cellular iron homeostasis as a common effect of EOfAD mutations in these genes. This idea is attractive since it provides clear connections between EOfAD mutations and major characteristics of Alzheimer&#39;s disease such as dysfunctional mitochondria, vascular risk factors/hypoxia, energy metabolism, and inflammation. We combine our ideas with observations by others to describe a &quot;St...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7edc46e08096cd49c7519dcc7503f977" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116734018,"asset_id":121978069,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116734018/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121978069"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121978069"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121978069; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121978069]").text(description); $(".js-view-count[data-work-id=121978069]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121978069; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121978069']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 121978069, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7edc46e08096cd49c7519dcc7503f977" } } $('.js-work-strip[data-work-id=121978069]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121978069,"title":"Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease","translated_title":"","metadata":{"abstract":"The overwhelming majority of dominant mutations causing early onset familial Alzheimer\u0026#39;s disease (EOfAD) occur in only three genes, , and . An effect-in-common of these mutations is alteration of production of the APP-derived peptide, amyloid β (Aβ). It is this key fact that underlies the authority of the Amyloid Hypothesis that has informed Alzheimer\u0026#39;s disease research for over two decades. Any challenge to this authority must offer an alternative explanation for the relationship between the genes and . In this paper, we explore one possible alternative relationship - the dysregulation of cellular iron homeostasis as a common effect of EOfAD mutations in these genes. This idea is attractive since it provides clear connections between EOfAD mutations and major characteristics of Alzheimer\u0026#39;s disease such as dysfunctional mitochondria, vascular risk factors/hypoxia, energy metabolism, and inflammation. We combine our ideas with observations by others to describe a \u0026quot;St...","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Frontiers in neuroscience"},"translated_abstract":"The overwhelming majority of dominant mutations causing early onset familial Alzheimer\u0026#39;s disease (EOfAD) occur in only three genes, , and . An effect-in-common of these mutations is alteration of production of the APP-derived peptide, amyloid β (Aβ). It is this key fact that underlies the authority of the Amyloid Hypothesis that has informed Alzheimer\u0026#39;s disease research for over two decades. Any challenge to this authority must offer an alternative explanation for the relationship between the genes and . In this paper, we explore one possible alternative relationship - the dysregulation of cellular iron homeostasis as a common effect of EOfAD mutations in these genes. This idea is attractive since it provides clear connections between EOfAD mutations and major characteristics of Alzheimer\u0026#39;s disease such as dysfunctional mitochondria, vascular risk factors/hypoxia, energy metabolism, and inflammation. We combine our ideas with observations by others to describe a \u0026quot;St...","internal_url":"https://www.academia.edu/121978069/Dysregulation_of_Neuronal_Iron_Homeostasis_as_an_Alternative_Unifying_Effect_of_Mutations_Causing_Familial_Alzheimers_Disease","translated_internal_url":"","created_at":"2024-07-11T22:14:50.524-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":116734018,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116734018/thumbnails/1.jpg","file_name":"271405.pdf","download_url":"https://www.academia.edu/attachments/116734018/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dysregulation_of_Neuronal_Iron_Homeostas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116734018/271405-libre.pdf?1720765573=\u0026response-content-disposition=attachment%3B+filename%3DDysregulation_of_Neuronal_Iron_Homeostas.pdf\u0026Expires=1732758176\u0026Signature=Ip8wu3ncveomHHaPzjYPyj5fMII-m-Opcs2Dvn1DH6eMoG8dVGIsp3YnWNCUDI5sL1gJeeldXLZtduxVsxupUuw2MBkA-jKSCZ-6be06YeCNEkNdx~4b81C~9qJrTi2M4nRIwCfABNnstD1efk9E9q-Lf3RGO1-ifyTxtC~W-1jvCKeou~ZXlnzJ5kPa9jPnV~nGLycp75zhzqBMBxPGXHNaxmehbrkVYz5ZnlsAVViKAKSSHEQPEEkNkJLnqlV1K6IWViOInw-hgmPPBvKEVkLtxNfFk1rFpwL2mNIB~EbUWxnlU~Qve3vfpfIHtGKyaNxUDnLdK9UPCOj7yY3TRQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Dysregulation_of_Neuronal_Iron_Homeostasis_as_an_Alternative_Unifying_Effect_of_Mutations_Causing_Familial_Alzheimers_Disease","translated_slug":"","page_count":21,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":116734018,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116734018/thumbnails/1.jpg","file_name":"271405.pdf","download_url":"https://www.academia.edu/attachments/116734018/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dysregulation_of_Neuronal_Iron_Homeostas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116734018/271405-libre.pdf?1720765573=\u0026response-content-disposition=attachment%3B+filename%3DDysregulation_of_Neuronal_Iron_Homeostas.pdf\u0026Expires=1732758176\u0026Signature=Ip8wu3ncveomHHaPzjYPyj5fMII-m-Opcs2Dvn1DH6eMoG8dVGIsp3YnWNCUDI5sL1gJeeldXLZtduxVsxupUuw2MBkA-jKSCZ-6be06YeCNEkNdx~4b81C~9qJrTi2M4nRIwCfABNnstD1efk9E9q-Lf3RGO1-ifyTxtC~W-1jvCKeou~ZXlnzJ5kPa9jPnV~nGLycp75zhzqBMBxPGXHNaxmehbrkVYz5ZnlsAVViKAKSSHEQPEEkNkJLnqlV1K6IWViOInw-hgmPPBvKEVkLtxNfFk1rFpwL2mNIB~EbUWxnlU~Qve3vfpfIHtGKyaNxUDnLdK9UPCOj7yY3TRQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience"},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":99773,"name":"Disease","url":"https://www.academia.edu/Documents/in/Disease"},{"id":452440,"name":"Presenilin-2","url":"https://www.academia.edu/Documents/in/Presenilin-2"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="120126583"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120126583/Early_Glycogen_Synthase_Kinase_3%CE%B2_GSK_3%CE%B2_and_Protein_Phosphatase_2A_PP2A_independent_tau_dephosphorylation_during_global_brain_ischemia_and_reperfusion_following_cardiac_arrest_and_the_role_of_the_Adenosine_Monophosphate_Kinase_AMPK_pathway"><img alt="Research paper thumbnail of Early Glycogen Synthase Kinase-3β (GSK-3β) and Protein Phosphatase 2A (PP2A) independent tau dephosphorylation during global brain ischemia and reperfusion following cardiac arrest and the role of the Adenosine Monophosphate Kinase (AMPK) pathway" class="work-thumbnail" src="https://attachments.academia-assets.com/115377719/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120126583/Early_Glycogen_Synthase_Kinase_3%CE%B2_GSK_3%CE%B2_and_Protein_Phosphatase_2A_PP2A_independent_tau_dephosphorylation_during_global_brain_ischemia_and_reperfusion_following_cardiac_arrest_and_the_role_of_the_Adenosine_Monophosphate_Kinase_AMPK_pathway">Early Glycogen Synthase Kinase-3β (GSK-3β) and Protein Phosphatase 2A (PP2A) independent tau dephosphorylation during global brain ischemia and reperfusion following cardiac arrest and the role of the Adenosine Monophosphate Kinase (AMPK) pathway</a></div><div class="wp-workCard_item"><span>The European journal of neuroscience</span><span>, Jan 14, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abnormal tau phosphorylation (p-tau) has been shown after hypoxic damage to the brain associated ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abnormal tau phosphorylation (p-tau) has been shown after hypoxic damage to the brain associated with traumatic brain injury and stroke. As the level of p-tau is controlled by Glycogen Synthase Kinase (GSK)-3β, Protein Phosphatase 2A (PP2A) and Adenosine Monophosphate Kinase (AMPK), different activity levels of these enzymes could be involved in tau phosphorylation following ischemia. This study assessed the effects of global brain ischemia/reperfusion on the immediate status of p-tau in a rat model of cardiac arrest (CA) followed by cardiopulmonary resuscitation (CPR). We reported an early dephosphorylation of tau at its AMPK sensitive residues, Ser(396) and Ser(262) after 2 min of ischemia, which did not recover during up to two hours of reperfusion, while the tau phosphorylation at GSK-3β sensitive but AMPK insensitive residues, Ser(202) /Thr(205) (AT8), as well as the total amount of tau remained unchanged. Our data showed no alteration in the activities of GSK-3β and PP2A durin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f4d57eeda026c470d7d0980f81f640df" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115377719,"asset_id":120126583,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115377719/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120126583"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120126583"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120126583; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120126583]").text(description); $(".js-view-count[data-work-id=120126583]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120126583; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120126583']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 120126583, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f4d57eeda026c470d7d0980f81f640df" } } $('.js-work-strip[data-work-id=120126583]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120126583,"title":"Early Glycogen Synthase Kinase-3β (GSK-3β) and Protein Phosphatase 2A (PP2A) independent tau dephosphorylation during global brain ischemia and reperfusion following cardiac arrest and the role of the Adenosine Monophosphate Kinase (AMPK) pathway","translated_title":"","metadata":{"abstract":"Abnormal tau phosphorylation (p-tau) has been shown after hypoxic damage to the brain associated with traumatic brain injury and stroke. As the level of p-tau is controlled by Glycogen Synthase Kinase (GSK)-3β, Protein Phosphatase 2A (PP2A) and Adenosine Monophosphate Kinase (AMPK), different activity levels of these enzymes could be involved in tau phosphorylation following ischemia. This study assessed the effects of global brain ischemia/reperfusion on the immediate status of p-tau in a rat model of cardiac arrest (CA) followed by cardiopulmonary resuscitation (CPR). We reported an early dephosphorylation of tau at its AMPK sensitive residues, Ser(396) and Ser(262) after 2 min of ischemia, which did not recover during up to two hours of reperfusion, while the tau phosphorylation at GSK-3β sensitive but AMPK insensitive residues, Ser(202) /Thr(205) (AT8), as well as the total amount of tau remained unchanged. Our data showed no alteration in the activities of GSK-3β and PP2A durin...","publication_date":{"day":14,"month":1,"year":2016,"errors":{}},"publication_name":"The European journal of neuroscience"},"translated_abstract":"Abnormal tau phosphorylation (p-tau) has been shown after hypoxic damage to the brain associated with traumatic brain injury and stroke. As the level of p-tau is controlled by Glycogen Synthase Kinase (GSK)-3β, Protein Phosphatase 2A (PP2A) and Adenosine Monophosphate Kinase (AMPK), different activity levels of these enzymes could be involved in tau phosphorylation following ischemia. This study assessed the effects of global brain ischemia/reperfusion on the immediate status of p-tau in a rat model of cardiac arrest (CA) followed by cardiopulmonary resuscitation (CPR). We reported an early dephosphorylation of tau at its AMPK sensitive residues, Ser(396) and Ser(262) after 2 min of ischemia, which did not recover during up to two hours of reperfusion, while the tau phosphorylation at GSK-3β sensitive but AMPK insensitive residues, Ser(202) /Thr(205) (AT8), as well as the total amount of tau remained unchanged. Our data showed no alteration in the activities of GSK-3β and PP2A durin...","internal_url":"https://www.academia.edu/120126583/Early_Glycogen_Synthase_Kinase_3%CE%B2_GSK_3%CE%B2_and_Protein_Phosphatase_2A_PP2A_independent_tau_dephosphorylation_during_global_brain_ischemia_and_reperfusion_following_cardiac_arrest_and_the_role_of_the_Adenosine_Monophosphate_Kinase_AMPK_pathway","translated_internal_url":"","created_at":"2024-05-27T16:53:23.687-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115377719,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115377719/thumbnails/1.jpg","file_name":"pmc5089632.pdf","download_url":"https://www.academia.edu/attachments/115377719/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Early_Glycogen_Synthase_Kinase_3_GSK_3.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115377719/pmc5089632-libre.pdf?1716856565=\u0026response-content-disposition=attachment%3B+filename%3DEarly_Glycogen_Synthase_Kinase_3_GSK_3.pdf\u0026Expires=1732758176\u0026Signature=D9Fo2FPYV8-J1qjtboJOekGVhpUuDunFfFXm78~1VlHZ6AfpK9h4rhuM~5tRECSIe3r3DcnWN-YnbbMU0mmmY7xSP6BEbKQcDXD9b94A4ii3lK1rkq9cAdQimVrj420qDrLRkWm936RtzBXn~7TdiuZypmouItJHT-PZAfx7aH4limzmCB2~YQ7JSV1RWjJbnEiXxu~HUkf7oB8hVA7hWTOb80FMcg6H-P2VIagAaS8yRsAzgzb8Wo00SlqLRPTE2lGY83codRHTqo7DT7RRkDXvPvgYKsnKqg7wJfUSFW96gGb3lO1xi0sZNhXrFrb~LUPQtD~cwsEZ6dnDRtIunw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Early_Glycogen_Synthase_Kinase_3β_GSK_3β_and_Protein_Phosphatase_2A_PP2A_independent_tau_dephosphorylation_during_global_brain_ischemia_and_reperfusion_following_cardiac_arrest_and_the_role_of_the_Adenosine_Monophosphate_Kinase_AMPK_pathway","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":115377719,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115377719/thumbnails/1.jpg","file_name":"pmc5089632.pdf","download_url":"https://www.academia.edu/attachments/115377719/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Early_Glycogen_Synthase_Kinase_3_GSK_3.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115377719/pmc5089632-libre.pdf?1716856565=\u0026response-content-disposition=attachment%3B+filename%3DEarly_Glycogen_Synthase_Kinase_3_GSK_3.pdf\u0026Expires=1732758176\u0026Signature=D9Fo2FPYV8-J1qjtboJOekGVhpUuDunFfFXm78~1VlHZ6AfpK9h4rhuM~5tRECSIe3r3DcnWN-YnbbMU0mmmY7xSP6BEbKQcDXD9b94A4ii3lK1rkq9cAdQimVrj420qDrLRkWm936RtzBXn~7TdiuZypmouItJHT-PZAfx7aH4limzmCB2~YQ7JSV1RWjJbnEiXxu~HUkf7oB8hVA7hWTOb80FMcg6H-P2VIagAaS8yRsAzgzb8Wo00SlqLRPTE2lGY83codRHTqo7DT7RRkDXvPvgYKsnKqg7wJfUSFW96gGb3lO1xi0sZNhXrFrb~LUPQtD~cwsEZ6dnDRtIunw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":172083,"name":"Phosphorylation","url":"https://www.academia.edu/Documents/in/Phosphorylation"},{"id":172084,"name":"AMPK","url":"https://www.academia.edu/Documents/in/AMPK"},{"id":223869,"name":"Protein Phosphatase 2A","url":"https://www.academia.edu/Documents/in/Protein_Phosphatase_2A"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1818690,"name":"Adenosine monophosphate","url":"https://www.academia.edu/Documents/in/Adenosine_monophosphate"},{"id":1953129,"name":"Dephosphorylation","url":"https://www.academia.edu/Documents/in/Dephosphorylation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="118605431"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/118605431/Access_to_Ambulance_Services_for_People_with_Dementia_A_Comprehensive_Review_of_Facts_Challenges_Strategies_and_Future_Scopes"><img alt="Research paper thumbnail of Access to Ambulance Services for People with Dementia: A Comprehensive Review of Facts, Challenges, Strategies and Future Scopes" class="work-thumbnail" src="https://attachments.academia-assets.com/114191115/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/118605431/Access_to_Ambulance_Services_for_People_with_Dementia_A_Comprehensive_Review_of_Facts_Challenges_Strategies_and_Future_Scopes">Access to Ambulance Services for People with Dementia: A Comprehensive Review of Facts, Challenges, Strategies and Future Scopes</a></div><div class="wp-workCard_item"><span>International Journal of Research Publication and Reviews</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3701d267359e19325e88701ed19297a5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":114191115,"asset_id":118605431,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/114191115/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="118605431"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="118605431"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 118605431; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=118605431]").text(description); $(".js-view-count[data-work-id=118605431]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 118605431; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='118605431']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 118605431, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3701d267359e19325e88701ed19297a5" } } $('.js-work-strip[data-work-id=118605431]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":118605431,"title":"Access to Ambulance Services for People with Dementia: A Comprehensive Review of Facts, Challenges, Strategies and Future Scopes","translated_title":"","metadata":{"publisher":"Genesis Global Publication","grobid_abstract":"Dementia is a progressive neurological impairment, causing a significant public health challenge worldwide. This pathological condition is characterized by cognitive decline and impairment in memory, thinking, behaviour, and the ability to perform daily activities. In Australia, dementia is a major health issue, with over 472,000 cases as of 2022. As the population ages, it is expected for this number to increase to 1.1 million by 2058, if no effective interventions are found. The impact of dementia on individuals, families, caregivers, and society in general, leads to an increase in demand for healthcare and emergency services. Currently, there is limited research on challenges that are faced by individuals with dementia in navigating the healthcare system for a timely and proper access to emergency care such as ambulance services. This review article will provide a comprehensive overview of the current state of research on the access of patients with dementia to ambulance services and the impact of dementia on ambulance utilization. This article also identifies the opportunities and directions for future research and interventions to improve the care and outcomes for individuals with dementia in the prehospital setting.","publication_name":"International Journal of Research Publication and Reviews","grobid_abstract_attachment_id":114191115},"translated_abstract":null,"internal_url":"https://www.academia.edu/118605431/Access_to_Ambulance_Services_for_People_with_Dementia_A_Comprehensive_Review_of_Facts_Challenges_Strategies_and_Future_Scopes","translated_internal_url":"","created_at":"2024-05-05T20:33:31.691-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":114191115,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/114191115/thumbnails/1.jpg","file_name":"gengpi.4.623.pdf","download_url":"https://www.academia.edu/attachments/114191115/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Access_to_Ambulance_Services_for_People.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/114191115/gengpi.4.623-libre.pdf?1714967168=\u0026response-content-disposition=attachment%3B+filename%3DAccess_to_Ambulance_Services_for_People.pdf\u0026Expires=1732758176\u0026Signature=Tfs~UlUmOhTOmiaHRu-SYSon8ieb-8XX6Jkh4q4BnY9iI~b-JFyZJ0frS5nW-6LW2G-czA-~gHFLo~O6j6kaGhzl-PgcKkf2dF-qnZ9TeyyOfjCKlz-LdkDzkmJVjB92U8-0poTH~NwTCIHV0Zpfb3Gg3FE2XCsR~v1l3ezY214mVXh9CbQLvazX8gRmQrqCnyDHFwehqojJWwYFE846jpVAYOunmT8zdV~96qDLj3COa0WfZVziawcQ2DLvX-eE6O9-9PUre-ta7ewFNOmbSnj8tlcZuUAyP2ipHPVOA~Fmccz3iWusJFOY4ccr~IGozq-05fe-a3~OCy210zIq3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Access_to_Ambulance_Services_for_People_with_Dementia_A_Comprehensive_Review_of_Facts_Challenges_Strategies_and_Future_Scopes","translated_slug":"","page_count":12,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":114191115,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/114191115/thumbnails/1.jpg","file_name":"gengpi.4.623.pdf","download_url":"https://www.academia.edu/attachments/114191115/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Access_to_Ambulance_Services_for_People.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/114191115/gengpi.4.623-libre.pdf?1714967168=\u0026response-content-disposition=attachment%3B+filename%3DAccess_to_Ambulance_Services_for_People.pdf\u0026Expires=1732758176\u0026Signature=Tfs~UlUmOhTOmiaHRu-SYSon8ieb-8XX6Jkh4q4BnY9iI~b-JFyZJ0frS5nW-6LW2G-czA-~gHFLo~O6j6kaGhzl-PgcKkf2dF-qnZ9TeyyOfjCKlz-LdkDzkmJVjB92U8-0poTH~NwTCIHV0Zpfb3Gg3FE2XCsR~v1l3ezY214mVXh9CbQLvazX8gRmQrqCnyDHFwehqojJWwYFE846jpVAYOunmT8zdV~96qDLj3COa0WfZVziawcQ2DLvX-eE6O9-9PUre-ta7ewFNOmbSnj8tlcZuUAyP2ipHPVOA~Fmccz3iWusJFOY4ccr~IGozq-05fe-a3~OCy210zIq3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115714170"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115714170/Evaluation_of_Cardiopulmonary_Resuscitation_CPR_Training_Programs_to_Schoolchildren_A_Comprehensive_Systematic_Review"><img alt="Research paper thumbnail of Evaluation of Cardiopulmonary Resuscitation (CPR) Training Programs to Schoolchildren: A Comprehensive Systematic Review" class="work-thumbnail" src="https://attachments.academia-assets.com/112510449/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115714170/Evaluation_of_Cardiopulmonary_Resuscitation_CPR_Training_Programs_to_Schoolchildren_A_Comprehensive_Systematic_Review">Evaluation of Cardiopulmonary Resuscitation (CPR) Training Programs to Schoolchildren: A Comprehensive Systematic Review</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/IRHDJournal">IRHD Journal</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MajdShohreh">Shohreh Majd</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MojcaBizjakMikic">Mojca Bizjak-Mikic</a></span></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cardiopulmonary resuscitation (CPR) is a lifesaving technique that holds immense significance in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cardiopulmonary resuscitation (CPR) is a lifesaving technique that holds immense significance in improving survival rates following cardiac arrest incidents. In the context of out-of-hospital cardiac arrest (OHCA), which remains a critical public health concern, the prompt initiation of CPR by bystanders significantly enhances the chances of survival. OHCA occurs suddenly and unexpectedly. Despite advancements in medical care, survival rates for OHCA remain low (Berdowski et al., 2010). According to Bystander CPR and Survival Rates, a study by Berdowski et al., the survival rate from OHCA in the US varied widely, ranging from</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6d16960355d0b2db8f46dbcd5f89df7b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112510449,"asset_id":115714170,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112510449/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115714170"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115714170"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115714170; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115714170]").text(description); $(".js-view-count[data-work-id=115714170]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115714170; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115714170']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115714170, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6d16960355d0b2db8f46dbcd5f89df7b" } } $('.js-work-strip[data-work-id=115714170]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115714170,"title":"Evaluation of Cardiopulmonary Resuscitation (CPR) Training Programs to Schoolchildren: A Comprehensive Systematic Review","translated_title":"","metadata":{"doi":"10.5281/zenodo.10828254","abstract":"Cardiopulmonary resuscitation (CPR) is a lifesaving technique that holds immense significance in improving survival rates following cardiac arrest incidents. In the context of out-of-hospital cardiac arrest (OHCA), which remains a critical public health concern, the prompt initiation of CPR by bystanders significantly enhances the chances of survival. OHCA occurs suddenly and unexpectedly. Despite advancements in medical care, survival rates for OHCA remain low (Berdowski et al., 2010). According to Bystander CPR and Survival Rates, a study by Berdowski et al., the survival rate from OHCA in the US varied widely, ranging from","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"Cardiopulmonary resuscitation (CPR) is a lifesaving technique that holds immense significance in improving survival rates following cardiac arrest incidents. In the context of out-of-hospital cardiac arrest (OHCA), which remains a critical public health concern, the prompt initiation of CPR by bystanders significantly enhances the chances of survival. OHCA occurs suddenly and unexpectedly. Despite advancements in medical care, survival rates for OHCA remain low (Berdowski et al., 2010). According to Bystander CPR and Survival Rates, a study by Berdowski et al., the survival rate from OHCA in the US varied widely, ranging from","internal_url":"https://www.academia.edu/115714170/Evaluation_of_Cardiopulmonary_Resuscitation_CPR_Training_Programs_to_Schoolchildren_A_Comprehensive_Systematic_Review","translated_internal_url":"","created_at":"2024-03-03T04:02:25.317-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41185643,"work_id":115714170,"tagging_user_id":282244998,"tagged_user_id":306498366,"co_author_invite_id":8076569,"email":"s***d@caa.net.au","display_order":1,"name":"Shohreh Majd","title":"Evaluation of Cardiopulmonary Resuscitation (CPR) Training Programs to Schoolchildren: A Comprehensive Systematic Review"},{"id":41185644,"work_id":115714170,"tagging_user_id":282244998,"tagged_user_id":305665511,"co_author_invite_id":8076570,"email":"d***s@caa.net.au","display_order":2,"name":"David Waters","title":"Evaluation of Cardiopulmonary Resuscitation (CPR) Training Programs to Schoolchildren: A Comprehensive Systematic Review"},{"id":41185645,"work_id":115714170,"tagging_user_id":282244998,"tagged_user_id":306085081,"co_author_invite_id":8076571,"email":"m***c@caa.net.au","display_order":3,"name":"Mojca Bizjak-Mikic","title":"Evaluation of Cardiopulmonary Resuscitation (CPR) Training Programs to Schoolchildren: A Comprehensive Systematic Review"}],"downloadable_attachments":[{"id":112510449,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112510449/thumbnails/1.jpg","file_name":"SchoolChirldren_CPR.docx.pdf","download_url":"https://www.academia.edu/attachments/112510449/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evaluation_of_Cardiopulmonary_Resuscitat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112510449/SchoolChirldren_CPR.docx-libre.pdf?1710720667=\u0026response-content-disposition=attachment%3B+filename%3DEvaluation_of_Cardiopulmonary_Resuscitat.pdf\u0026Expires=1732758176\u0026Signature=gDd1pt-MtfRIQlIeKSaGy9TwhpsZXcx2ks83uqV2qfvDXmu6DHOV2OM7PoRSD~ZxfvIzDJUBmoU3roYcOZt3STAY38lvxxgkrOngPLPwMfTqoVt913IoBzvzQxL66T2uMJcG2-GYZuQVs8g177-DZLzC6FZx-O2WnzGUbjsJkOghHCNToL3FFonkPMrHFFL8jk8IInBoRUVsQ85JI0tRVA62UL2~HCdHpgAdxRC7C4A~zGeYzq7iJ~0eUAx8pGIPml1DyK0XMDHUr3W1gSv49jg1T9-1QQ~aB-NHVCpD8lccsqFV-L1XHya0gN2EnPRlV~Uh06L7TNgqZVZDqQCRtA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Evaluation_of_Cardiopulmonary_Resuscitation_CPR_Training_Programs_to_Schoolchildren_A_Comprehensive_Systematic_Review","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":112510449,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112510449/thumbnails/1.jpg","file_name":"SchoolChirldren_CPR.docx.pdf","download_url":"https://www.academia.edu/attachments/112510449/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evaluation_of_Cardiopulmonary_Resuscitat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112510449/SchoolChirldren_CPR.docx-libre.pdf?1710720667=\u0026response-content-disposition=attachment%3B+filename%3DEvaluation_of_Cardiopulmonary_Resuscitat.pdf\u0026Expires=1732758176\u0026Signature=gDd1pt-MtfRIQlIeKSaGy9TwhpsZXcx2ks83uqV2qfvDXmu6DHOV2OM7PoRSD~ZxfvIzDJUBmoU3roYcOZt3STAY38lvxxgkrOngPLPwMfTqoVt913IoBzvzQxL66T2uMJcG2-GYZuQVs8g177-DZLzC6FZx-O2WnzGUbjsJkOghHCNToL3FFonkPMrHFFL8jk8IInBoRUVsQ85JI0tRVA62UL2~HCdHpgAdxRC7C4A~zGeYzq7iJ~0eUAx8pGIPml1DyK0XMDHUr3W1gSv49jg1T9-1QQ~aB-NHVCpD8lccsqFV-L1XHya0gN2EnPRlV~Uh06L7TNgqZVZDqQCRtA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4441,"name":"Health Care","url":"https://www.academia.edu/Documents/in/Health_Care"},{"id":258680,"name":"Cardiopulmonary Resuscitation","url":"https://www.academia.edu/Documents/in/Cardiopulmonary_Resuscitation"},{"id":487398,"name":"Ambulance","url":"https://www.academia.edu/Documents/in/Ambulance"},{"id":836015,"name":"Studies on First Aid Awareness","url":"https://www.academia.edu/Documents/in/Studies_on_First_Aid_Awareness"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114616965"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114616965/Advancing_Childrens_Mental_Health_and_Wellbeing_Through_Healthcare_Policies"><img alt="Research paper thumbnail of Advancing Children's Mental Health and Wellbeing Through Healthcare Policies" class="work-thumbnail" src="https://attachments.academia-assets.com/111676280/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114616965/Advancing_Childrens_Mental_Health_and_Wellbeing_Through_Healthcare_Policies">Advancing Children's Mental Health and Wellbeing Through Healthcare Policies</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Children's mental health and wellbeing are fundamental components of their overall development an...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Children's mental health and wellbeing are fundamental components of their overall development and quality of life. Developing effective healthcare policies aimed at promoting and safeguarding children's mental health is crucial for addressing the growing challenges in this domain. That brings a need for a comprehensive examination of the different aspects and significance of healthcare policies focused on children's mental health and wellbeing, addressing these challenges. The various dimensions of policy development, implementation, and evaluation demand a holistic approach that integrates preventive, promotive, and therapeutic interventions. Drawing on insights from interdisciplinary fields such as psychology, public health, and policy analysis, this article offers practical and feasible recommendations for policymakers, healthcare practitioners, and researchers to enhance the effectiveness of children's mental health policies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="230171ae47346b2600f92c6088f60603" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111676280,"asset_id":114616965,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111676280/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114616965"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114616965"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114616965; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114616965]").text(description); $(".js-view-count[data-work-id=114616965]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114616965; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114616965']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114616965, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "230171ae47346b2600f92c6088f60603" } } $('.js-work-strip[data-work-id=114616965]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114616965,"title":"Advancing Children's Mental Health and Wellbeing Through Healthcare Policies","translated_title":"","metadata":{"doi":"10686046","issue":"1","volume":"2","abstract":"Children's mental health and wellbeing are fundamental components of their overall development and quality of life. Developing effective healthcare policies aimed at promoting and safeguarding children's mental health is crucial for addressing the growing challenges in this domain. That brings a need for a comprehensive examination of the different aspects and significance of healthcare policies focused on children's mental health and wellbeing, addressing these challenges. The various dimensions of policy development, implementation, and evaluation demand a holistic approach that integrates preventive, promotive, and therapeutic interventions. Drawing on insights from interdisciplinary fields such as psychology, public health, and policy analysis, this article offers practical and feasible recommendations for policymakers, healthcare practitioners, and researchers to enhance the effectiveness of children's mental health policies.","page_numbers":"29-39","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"Children's mental health and wellbeing are fundamental components of their overall development and quality of life. Developing effective healthcare policies aimed at promoting and safeguarding children's mental health is crucial for addressing the growing challenges in this domain. That brings a need for a comprehensive examination of the different aspects and significance of healthcare policies focused on children's mental health and wellbeing, addressing these challenges. The various dimensions of policy development, implementation, and evaluation demand a holistic approach that integrates preventive, promotive, and therapeutic interventions. Drawing on insights from interdisciplinary fields such as psychology, public health, and policy analysis, this article offers practical and feasible recommendations for policymakers, healthcare practitioners, and researchers to enhance the effectiveness of children's mental health policies.","internal_url":"https://www.academia.edu/114616965/Advancing_Childrens_Mental_Health_and_Wellbeing_Through_Healthcare_Policies","translated_internal_url":"","created_at":"2024-02-07T17:50:34.331-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41055790,"work_id":114616965,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":1,"name":"Shohreh Majd","title":"Advancing Children's Mental Health and Wellbeing Through Healthcare Policies"}],"downloadable_attachments":[{"id":111676280,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111676280/thumbnails/1.jpg","file_name":"5_Children_Mental_Health.pdf","download_url":"https://www.academia.edu/attachments/111676280/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Advancing_Childrens_Mental_Health_and_We.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111676280/5_Children_Mental_Health-libre.pdf?1708497737=\u0026response-content-disposition=attachment%3B+filename%3DAdvancing_Childrens_Mental_Health_and_We.pdf\u0026Expires=1732758176\u0026Signature=b-Sek8F1eU8iN5lOIk22nMlTUEKMiPcL5M0HWyYvmIY~mMLWerD5rjuMFl54Z85jhbXtuWFcxmI-Jht~MC2kJricN4pwy40pBfszg-ly39GJ~d~7E6WhwXE0UmLMl22V1WxEw52BauNHRXWGb4IQoVl-beJTvXojFIXe39u-3haUUFFH5c1TEIm3xf4FLvlbaiXwNdi-sdlYOJZAtmqj24c7B~XRH4N4H1FJAbVO3wdobdVA-8w2LGAxyd3aHOuUzw20w1GAUY~vvQwnUPfzsY0Q65fLjudElVTAnWgGnh5uopiGi75yDh4jLUzQJihAi8RshrIBcTOmIuCyvOyXeA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Advancing_Childrens_Mental_Health_and_Wellbeing_Through_Healthcare_Policies","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111676280,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111676280/thumbnails/1.jpg","file_name":"5_Children_Mental_Health.pdf","download_url":"https://www.academia.edu/attachments/111676280/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Advancing_Childrens_Mental_Health_and_We.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111676280/5_Children_Mental_Health-libre.pdf?1708497737=\u0026response-content-disposition=attachment%3B+filename%3DAdvancing_Childrens_Mental_Health_and_We.pdf\u0026Expires=1732758176\u0026Signature=b-Sek8F1eU8iN5lOIk22nMlTUEKMiPcL5M0HWyYvmIY~mMLWerD5rjuMFl54Z85jhbXtuWFcxmI-Jht~MC2kJricN4pwy40pBfszg-ly39GJ~d~7E6WhwXE0UmLMl22V1WxEw52BauNHRXWGb4IQoVl-beJTvXojFIXe39u-3haUUFFH5c1TEIm3xf4FLvlbaiXwNdi-sdlYOJZAtmqj24c7B~XRH4N4H1FJAbVO3wdobdVA-8w2LGAxyd3aHOuUzw20w1GAUY~vvQwnUPfzsY0Q65fLjudElVTAnWgGnh5uopiGi75yDh4jLUzQJihAi8RshrIBcTOmIuCyvOyXeA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":2827,"name":"Mental Health","url":"https://www.academia.edu/Documents/in/Mental_Health"},{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health"},{"id":29840,"name":"Public Policy Development","url":"https://www.academia.edu/Documents/in/Public_Policy_Development"},{"id":827809,"name":"Mental Health of Children and Young People","url":"https://www.academia.edu/Documents/in/Mental_Health_of_Children_and_Young_People"},{"id":979904,"name":"Publich Health Policy","url":"https://www.academia.edu/Documents/in/Publich_Health_Policy"}],"urls":[{"id":39655271,"url":"https://integratedrhd.com/2024-21-p29-39/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114569538"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114569538/Promoting_Public_Health_Trainings_in_Diverse_Communities"><img alt="Research paper thumbnail of Promoting Public Health Trainings in Diverse Communities" class="work-thumbnail" src="https://attachments.academia-assets.com/111675873/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114569538/Promoting_Public_Health_Trainings_in_Diverse_Communities">Promoting Public Health Trainings in Diverse Communities</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Public health trainings hold a pivotal role in bolstering communities against health challenges, ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Public health trainings hold a pivotal role in bolstering communities against health challenges, nurturing well-being, and fostering equitable access to healthcare. This article delves into the multifaceted significance of public health trainings, emphasizing their impact on enhancing health literacy, preventing diseases, and improving healthcare access across diverse communities. Through tailored interventions, individuals are empowered to make informed health decisions, cultivate healthy behaviours, and navigate intricate healthcare systems. These trainings address barriers to healthcare access and promote cultural competence, contributing to the establishment of inclusive healthcare ecosystems conducive to optimal health outcomes and societal resilience. Disseminating evidence-based information, fostering community engagement, and facilitating resource accessibility, public health trainings empower individuals to proactively enhance their health. Moreover, fostering collaboration between healthcare providers and community members, these initiatives bridge gaps in healthcare delivery, ensuring responsiveness to the unique needs of each population. Ultimately, public health trainings serve as linchpins of community health promotion, fostering empowerment, resilience, and equitable healthcare access for all.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3b4ab1d127d8e4e61afaab732f209f13" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111675873,"asset_id":114569538,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111675873/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114569538"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114569538"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114569538; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114569538]").text(description); $(".js-view-count[data-work-id=114569538]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114569538; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114569538']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114569538, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3b4ab1d127d8e4e61afaab732f209f13" } } $('.js-work-strip[data-work-id=114569538]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114569538,"title":"Promoting Public Health Trainings in Diverse Communities","translated_title":"","metadata":{"doi":"10.5281/zenodo.10686017","issue":"1","volume":"2","abstract":"Public health trainings hold a pivotal role in bolstering communities against health challenges, nurturing well-being, and fostering equitable access to healthcare. This article delves into the multifaceted significance of public health trainings, emphasizing their impact on enhancing health literacy, preventing diseases, and improving healthcare access across diverse communities. Through tailored interventions, individuals are empowered to make informed health decisions, cultivate healthy behaviours, and navigate intricate healthcare systems. These trainings address barriers to healthcare access and promote cultural competence, contributing to the establishment of inclusive healthcare ecosystems conducive to optimal health outcomes and societal resilience. Disseminating evidence-based information, fostering community engagement, and facilitating resource accessibility, public health trainings empower individuals to proactively enhance their health. Moreover, fostering collaboration between healthcare providers and community members, these initiatives bridge gaps in healthcare delivery, ensuring responsiveness to the unique needs of each population. Ultimately, public health trainings serve as linchpins of community health promotion, fostering empowerment, resilience, and equitable healthcare access for all.","page_numbers":"24-28","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"Public health trainings hold a pivotal role in bolstering communities against health challenges, nurturing well-being, and fostering equitable access to healthcare. This article delves into the multifaceted significance of public health trainings, emphasizing their impact on enhancing health literacy, preventing diseases, and improving healthcare access across diverse communities. Through tailored interventions, individuals are empowered to make informed health decisions, cultivate healthy behaviours, and navigate intricate healthcare systems. These trainings address barriers to healthcare access and promote cultural competence, contributing to the establishment of inclusive healthcare ecosystems conducive to optimal health outcomes and societal resilience. Disseminating evidence-based information, fostering community engagement, and facilitating resource accessibility, public health trainings empower individuals to proactively enhance their health. Moreover, fostering collaboration between healthcare providers and community members, these initiatives bridge gaps in healthcare delivery, ensuring responsiveness to the unique needs of each population. Ultimately, public health trainings serve as linchpins of community health promotion, fostering empowerment, resilience, and equitable healthcare access for all.","internal_url":"https://www.academia.edu/114569538/Promoting_Public_Health_Trainings_in_Diverse_Communities","translated_internal_url":"","created_at":"2024-02-06T15:34:12.024-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41050346,"work_id":114569538,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":8053328,"email":"a***6@gmail.com","display_order":2,"name":"Agarwal V","title":"Promoting Public Health Trainings in Diverse Communities"}],"downloadable_attachments":[{"id":111675873,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111675873/thumbnails/1.jpg","file_name":"4_Public_Health.pdf","download_url":"https://www.academia.edu/attachments/111675873/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Promoting_Public_Health_Trainings_in_Div.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111675873/4_Public_Health-libre.pdf?1708497808=\u0026response-content-disposition=attachment%3B+filename%3DPromoting_Public_Health_Trainings_in_Div.pdf\u0026Expires=1732758176\u0026Signature=AYus4ATPGqQKOCb4yiT2F4u~HUV9ni8rfDKBi-T4lYTUa7cO9pkat9pPdmwZM0en4LlGDjygR1c~AxdWthqdpcnAmQea242Q4dliW3DH371APxcu0wHlPAvd2RxC7jXmmPdXizzkF3Eqmwdd1yQtJKfSL4k5QlOsOY7B21j3ruhE48znP~f3NwLfAYpAkRM14oltZqFqAK15JrvgH~pcbdSXgaqtVDe4ohy71DmuS9KvIy8pws4RJh~JszyieJIWVjVd~kL8TYPpF6kh0qoWEUBGVBfTSw~LpVF-6UBX4BV04JH3TQVf~LYwKRBsxGiYoGauGz47Xds87TdrFCY~Fw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Promoting_Public_Health_Trainings_in_Diverse_Communities","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111675873,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111675873/thumbnails/1.jpg","file_name":"4_Public_Health.pdf","download_url":"https://www.academia.edu/attachments/111675873/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Promoting_Public_Health_Trainings_in_Div.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111675873/4_Public_Health-libre.pdf?1708497808=\u0026response-content-disposition=attachment%3B+filename%3DPromoting_Public_Health_Trainings_in_Div.pdf\u0026Expires=1732758176\u0026Signature=AYus4ATPGqQKOCb4yiT2F4u~HUV9ni8rfDKBi-T4lYTUa7cO9pkat9pPdmwZM0en4LlGDjygR1c~AxdWthqdpcnAmQea242Q4dliW3DH371APxcu0wHlPAvd2RxC7jXmmPdXizzkF3Eqmwdd1yQtJKfSL4k5QlOsOY7B21j3ruhE48znP~f3NwLfAYpAkRM14oltZqFqAK15JrvgH~pcbdSXgaqtVDe4ohy71DmuS9KvIy8pws4RJh~JszyieJIWVjVd~kL8TYPpF6kh0qoWEUBGVBfTSw~LpVF-6UBX4BV04JH3TQVf~LYwKRBsxGiYoGauGz47Xds87TdrFCY~Fw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":922,"name":"Education","url":"https://www.academia.edu/Documents/in/Education"},{"id":981,"name":"Health Promotion","url":"https://www.academia.edu/Documents/in/Health_Promotion"},{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health"},{"id":35646,"name":"Community Empowerment","url":"https://www.academia.edu/Documents/in/Community_Empowerment"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114529807"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114529807/The_Bidirectional_Relationship_Between_Depression_and_High_Blood_Pressure"><img alt="Research paper thumbnail of The Bidirectional Relationship Between Depression and High Blood Pressure" class="work-thumbnail" src="https://attachments.academia-assets.com/111675698/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114529807/The_Bidirectional_Relationship_Between_Depression_and_High_Blood_Pressure">The Bidirectional Relationship Between Depression and High Blood Pressure</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">High blood pressure (HBP) stands as a critical public health concern, given its pervasive nature ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">High blood pressure (HBP) stands as a critical public health concern, given its pervasive nature and the substantial morbidity and mortality associated with its complications, including cardiovascular diseases, stroke, and renal failure. With its silent and insidious progression, HBP often manifests asymptomatically. Concurrently, depression, a prevalent mental health disorder affecting millions worldwide, has emerged as a significant player in the intricate web of health-related interconnections. Extensive epidemiological evidence has shed light on the bidirectional relationship between depression and HBP, suggesting that individuals grappling with depression face an augmented risk of developing HBP, and conversely, those with HBP are more susceptible to depressive disorders. This intricate association is underscored by the intricate interplay of neurobiological, hormonal, and inflammatory mechanisms, fuelling a cycle that perpetuates the progression of both conditions. Here, we aim to provide a comprehensive synthesis of the existing scientific data and to promote a deeper understanding of this bidirectional relationship and illuminate avenues for targeted interventions that can concurrently address mental and cardiovascular health.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f940cb77978ff88978a76ce03ffa23f9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111675698,"asset_id":114529807,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111675698/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114529807"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114529807"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114529807; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114529807]").text(description); $(".js-view-count[data-work-id=114529807]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114529807; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114529807']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114529807, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f940cb77978ff88978a76ce03ffa23f9" } } $('.js-work-strip[data-work-id=114529807]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114529807,"title":"The Bidirectional Relationship Between Depression and High Blood Pressure","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685968","issue":"1","volume":"2","abstract":"High blood pressure (HBP) stands as a critical public health concern, given its pervasive nature and the substantial morbidity and mortality associated with its complications, including cardiovascular diseases, stroke, and renal failure. With its silent and insidious progression, HBP often manifests asymptomatically. Concurrently, depression, a prevalent mental health disorder affecting millions worldwide, has emerged as a significant player in the intricate web of health-related interconnections. Extensive epidemiological evidence has shed light on the bidirectional relationship between depression and HBP, suggesting that individuals grappling with depression face an augmented risk of developing HBP, and conversely, those with HBP are more susceptible to depressive disorders. This intricate association is underscored by the intricate interplay of neurobiological, hormonal, and inflammatory mechanisms, fuelling a cycle that perpetuates the progression of both conditions. Here, we aim to provide a comprehensive synthesis of the existing scientific data and to promote a deeper understanding of this bidirectional relationship and illuminate avenues for targeted interventions that can concurrently address mental and cardiovascular health.","page_numbers":"15-23","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"High blood pressure (HBP) stands as a critical public health concern, given its pervasive nature and the substantial morbidity and mortality associated with its complications, including cardiovascular diseases, stroke, and renal failure. With its silent and insidious progression, HBP often manifests asymptomatically. Concurrently, depression, a prevalent mental health disorder affecting millions worldwide, has emerged as a significant player in the intricate web of health-related interconnections. Extensive epidemiological evidence has shed light on the bidirectional relationship between depression and HBP, suggesting that individuals grappling with depression face an augmented risk of developing HBP, and conversely, those with HBP are more susceptible to depressive disorders. This intricate association is underscored by the intricate interplay of neurobiological, hormonal, and inflammatory mechanisms, fuelling a cycle that perpetuates the progression of both conditions. Here, we aim to provide a comprehensive synthesis of the existing scientific data and to promote a deeper understanding of this bidirectional relationship and illuminate avenues for targeted interventions that can concurrently address mental and cardiovascular health.","internal_url":"https://www.academia.edu/114529807/The_Bidirectional_Relationship_Between_Depression_and_High_Blood_Pressure","translated_internal_url":"","created_at":"2024-02-05T20:04:15.540-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41044850,"work_id":114529807,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":5,"name":"Shohreh Majd","title":"The Bidirectional Relationship Between Depression and High Blood Pressure"}],"downloadable_attachments":[{"id":111675698,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111675698/thumbnails/1.jpg","file_name":"3_Depression_and_HBP.pdf","download_url":"https://www.academia.edu/attachments/111675698/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Bidirectional_Relationship_Between_D.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111675698/3_Depression_and_HBP-libre.pdf?1708497845=\u0026response-content-disposition=attachment%3B+filename%3DThe_Bidirectional_Relationship_Between_D.pdf\u0026Expires=1732758176\u0026Signature=XzCH-gvuusa~a0X84~~x2RYXLy1eKBdZP~t09P36JoXYst1btsoxGW3NEtP-VMy6UeTvMRDLjB6lNiY9Qg-ej7PRLSQa9Y4LiLrBNm0d~0BkHiLw88qXNEM6YgXS24qiMQ-YsdZC~rRnSZ8AMClePzJaM~8xNvRwZdW0~APJYbNroOBD~tQZjxuHHGF60LnJ4F-1WLcoCOKUoai9d1si80EDEpGNIC07MWcAorUbPrz4OePW5miDIXgATnHBU4746IKN0O6afwsYlvFG7VQ2gU8-lvnHlBVOeUwzYmLXcxrfO2VCczgots4LXijnl-~PbkKGqhlaQ~eCeLzIuXjWAw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Bidirectional_Relationship_Between_Depression_and_High_Blood_Pressure","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111675698,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111675698/thumbnails/1.jpg","file_name":"3_Depression_and_HBP.pdf","download_url":"https://www.academia.edu/attachments/111675698/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Bidirectional_Relationship_Between_D.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111675698/3_Depression_and_HBP-libre.pdf?1708497845=\u0026response-content-disposition=attachment%3B+filename%3DThe_Bidirectional_Relationship_Between_D.pdf\u0026Expires=1732758176\u0026Signature=XzCH-gvuusa~a0X84~~x2RYXLy1eKBdZP~t09P36JoXYst1btsoxGW3NEtP-VMy6UeTvMRDLjB6lNiY9Qg-ej7PRLSQa9Y4LiLrBNm0d~0BkHiLw88qXNEM6YgXS24qiMQ-YsdZC~rRnSZ8AMClePzJaM~8xNvRwZdW0~APJYbNroOBD~tQZjxuHHGF60LnJ4F-1WLcoCOKUoai9d1si80EDEpGNIC07MWcAorUbPrz4OePW5miDIXgATnHBU4746IKN0O6afwsYlvFG7VQ2gU8-lvnHlBVOeUwzYmLXcxrfO2VCczgots4LXijnl-~PbkKGqhlaQ~eCeLzIuXjWAw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":168,"name":"Human Physiology","url":"https://www.academia.edu/Documents/in/Human_Physiology"},{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":2827,"name":"Mental Health","url":"https://www.academia.edu/Documents/in/Mental_Health"},{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension"},{"id":689957,"name":"Cardivascular Disease","url":"https://www.academia.edu/Documents/in/Cardivascular_Disease"}],"urls":[{"id":39654658,"url":"https://integratedrhd.com/2024-21-p15-23/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114321575"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114321575/The_Interplay_between_Chronic_Kidney_Disease_and_Dementia"><img alt="Research paper thumbnail of The Interplay between Chronic Kidney Disease and Dementia" class="work-thumbnail" src="https://attachments.academia-assets.com/111675283/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114321575/The_Interplay_between_Chronic_Kidney_Disease_and_Dementia">The Interplay between Chronic Kidney Disease and Dementia</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The interplay between chronic kidney disease (CKD) and dementia holds paramount significance in g...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The interplay between chronic kidney disease (CKD) and dementia holds paramount significance in global public health, given the prevalence and debilitating nature of these conditions. Recent evidence underscores a bidirectional relationship between kidney disease and cognitive impairment, emphasizing the need for in-depth exploration into shared risk factors and mechanistic pathways connecting these disorders. This article comprehensively reviews the intricate relationship between CKD and dementia, delving into the bidirectional link, shared risk factors, and mechanistic pathways inherent to these prevalent and debilitating conditions. Furthermore, we explore the impact of kidney disease on cognitive function and delves into the implications for patient care, providing a comprehensive overview of the multifaceted interconnection between CKD and dementia.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cd1286eaf1952d56dcd36b87ee6a7688" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111675283,"asset_id":114321575,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111675283/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114321575"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114321575"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114321575; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114321575]").text(description); $(".js-view-count[data-work-id=114321575]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114321575; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114321575']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114321575, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cd1286eaf1952d56dcd36b87ee6a7688" } } $('.js-work-strip[data-work-id=114321575]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114321575,"title":"The Interplay between Chronic Kidney Disease and Dementia","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685944","issue":"1","volume":"2","abstract":"The interplay between chronic kidney disease (CKD) and dementia holds paramount significance in global public health, given the prevalence and debilitating nature of these conditions. Recent evidence underscores a bidirectional relationship between kidney disease and cognitive impairment, emphasizing the need for in-depth exploration into shared risk factors and mechanistic pathways connecting these disorders. This article comprehensively reviews the intricate relationship between CKD and dementia, delving into the bidirectional link, shared risk factors, and mechanistic pathways inherent to these prevalent and debilitating conditions. Furthermore, we explore the impact of kidney disease on cognitive function and delves into the implications for patient care, providing a comprehensive overview of the multifaceted interconnection between CKD and dementia.","page_numbers":"7-14","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"The interplay between chronic kidney disease (CKD) and dementia holds paramount significance in global public health, given the prevalence and debilitating nature of these conditions. Recent evidence underscores a bidirectional relationship between kidney disease and cognitive impairment, emphasizing the need for in-depth exploration into shared risk factors and mechanistic pathways connecting these disorders. This article comprehensively reviews the intricate relationship between CKD and dementia, delving into the bidirectional link, shared risk factors, and mechanistic pathways inherent to these prevalent and debilitating conditions. Furthermore, we explore the impact of kidney disease on cognitive function and delves into the implications for patient care, providing a comprehensive overview of the multifaceted interconnection between CKD and dementia.","internal_url":"https://www.academia.edu/114321575/The_Interplay_between_Chronic_Kidney_Disease_and_Dementia","translated_internal_url":"","created_at":"2024-01-31T19:00:39.198-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41017689,"work_id":114321575,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":2,"name":"Shohreh Majd","title":"The Interplay between Chronic Kidney Disease and Dementia"},{"id":41017688,"work_id":114321575,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":8047360,"email":"y***0@gmail.com","display_order":5,"name":"Yejun Jang","title":"The Interplay between Chronic Kidney Disease and Dementia"}],"downloadable_attachments":[{"id":111675283,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111675283/thumbnails/1.jpg","file_name":"2_CKD_Dementia.pdf","download_url":"https://www.academia.edu/attachments/111675283/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Interplay_between_Chronic_Kidney_Dis.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111675283/2_CKD_Dementia-libre.pdf?1708493766=\u0026response-content-disposition=attachment%3B+filename%3DThe_Interplay_between_Chronic_Kidney_Dis.pdf\u0026Expires=1732758176\u0026Signature=dNgSsPaTbxbbeQ1Qvc03lFYw10kAqw3aUjUQE49cHrekoJ4GyH8-PFXluBbUzXB0EYe4zKakjR7b4Xeg3vO7Fro2~KpRUvvwI4OyyHi454hiBkvUoa14~-nYmTq7sQ6v58QyuyXaZHleJ80uHH-gyRSqZFDo4d2D0CD4rob-z2Vj8bhjrErunfyl~hSwxGIdYtIzoj~ClWFS4f91Mk3BDJ2E5WJfEkJlgAtsiiWnYGJOjijwvHON7Ls13F8b5X6HmYEyR2jagP1Dpe~1yp9W7N54v1hpAxR8G-iAYVYaAvw8MEbCtoS5C5zhboEFR~0EwGBMrXcwfXM~9Jg0DBkX~g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Interplay_between_Chronic_Kidney_Disease_and_Dementia","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111675283,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111675283/thumbnails/1.jpg","file_name":"2_CKD_Dementia.pdf","download_url":"https://www.academia.edu/attachments/111675283/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Interplay_between_Chronic_Kidney_Dis.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111675283/2_CKD_Dementia-libre.pdf?1708493766=\u0026response-content-disposition=attachment%3B+filename%3DThe_Interplay_between_Chronic_Kidney_Dis.pdf\u0026Expires=1732758176\u0026Signature=dNgSsPaTbxbbeQ1Qvc03lFYw10kAqw3aUjUQE49cHrekoJ4GyH8-PFXluBbUzXB0EYe4zKakjR7b4Xeg3vO7Fro2~KpRUvvwI4OyyHi454hiBkvUoa14~-nYmTq7sQ6v58QyuyXaZHleJ80uHH-gyRSqZFDo4d2D0CD4rob-z2Vj8bhjrErunfyl~hSwxGIdYtIzoj~ClWFS4f91Mk3BDJ2E5WJfEkJlgAtsiiWnYGJOjijwvHON7Ls13F8b5X6HmYEyR2jagP1Dpe~1yp9W7N54v1hpAxR8G-iAYVYaAvw8MEbCtoS5C5zhboEFR~0EwGBMrXcwfXM~9Jg0DBkX~g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3776,"name":"Alzheimer's Disease","url":"https://www.academia.edu/Documents/in/Alzheimers_Disease"},{"id":9001,"name":"Chronic kidney disease","url":"https://www.academia.edu/Documents/in/Chronic_kidney_disease"}],"urls":[{"id":39654247,"url":"https://integratedrhd.com/2024-21-p7-14/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114176528"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114176528/Prevalence_of_Periodontal_Disease_Its_Association_with_Systemic_Diseases_and_Prevention"><img alt="Research paper thumbnail of Prevalence of Periodontal Disease, Its Association with Systemic Diseases, and Prevention" class="work-thumbnail" src="https://attachments.academia-assets.com/111674943/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114176528/Prevalence_of_Periodontal_Disease_Its_Association_with_Systemic_Diseases_and_Prevention">Prevalence of Periodontal Disease, Its Association with Systemic Diseases, and Prevention</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Periodontal disease is a prevalent oral health issue affecting a significant portion of the globa...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Periodontal disease is a prevalent oral health issue affecting a significant portion of the global population. The multifactorial etiology of periodontal disease involves dysregulated host responses to microbial biofilm, leading to progressive tissue destruction, ranging from reversible gingivitis to irreversible stages impacting periodontal ligament and alveolar bone. Variations in disease prevalence among populations underscore the influence of factors like age, gender, and socioeconomic status. Emphasizing the pivotal role of effective oral hygiene practices, this review delves into the global prevalence of periodontal disease, noting regional disparities influenced by cultural practices, socioeconomic conditions, and healthcare accessibility. Here we also explore the bidirectional relationship between periodontal disease and systemic conditions, focusing on diabetes mellitus, cardiovascular diseases, and rheumatoid arthritis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="610a3652b1b70d9477d65f94755850c0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111674943,"asset_id":114176528,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111674943/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114176528"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114176528"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114176528; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114176528]").text(description); $(".js-view-count[data-work-id=114176528]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114176528; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114176528']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114176528, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "610a3652b1b70d9477d65f94755850c0" } } $('.js-work-strip[data-work-id=114176528]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114176528,"title":"Prevalence of Periodontal Disease, Its Association with Systemic Diseases, and Prevention","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685921","abstract":"Periodontal disease is a prevalent oral health issue affecting a significant portion of the global population. The multifactorial etiology of periodontal disease involves dysregulated host responses to microbial biofilm, leading to progressive tissue destruction, ranging from reversible gingivitis to irreversible stages impacting periodontal ligament and alveolar bone. Variations in disease prevalence among populations underscore the influence of factors like age, gender, and socioeconomic status. Emphasizing the pivotal role of effective oral hygiene practices, this review delves into the global prevalence of periodontal disease, noting regional disparities influenced by cultural practices, socioeconomic conditions, and healthcare accessibility. Here we also explore the bidirectional relationship between periodontal disease and systemic conditions, focusing on diabetes mellitus, cardiovascular diseases, and rheumatoid arthritis.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"Periodontal disease is a prevalent oral health issue affecting a significant portion of the global population. The multifactorial etiology of periodontal disease involves dysregulated host responses to microbial biofilm, leading to progressive tissue destruction, ranging from reversible gingivitis to irreversible stages impacting periodontal ligament and alveolar bone. Variations in disease prevalence among populations underscore the influence of factors like age, gender, and socioeconomic status. Emphasizing the pivotal role of effective oral hygiene practices, this review delves into the global prevalence of periodontal disease, noting regional disparities influenced by cultural practices, socioeconomic conditions, and healthcare accessibility. Here we also explore the bidirectional relationship between periodontal disease and systemic conditions, focusing on diabetes mellitus, cardiovascular diseases, and rheumatoid arthritis.","internal_url":"https://www.academia.edu/114176528/Prevalence_of_Periodontal_Disease_Its_Association_with_Systemic_Diseases_and_Prevention","translated_internal_url":"","created_at":"2024-01-28T20:02:42.854-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40999832,"work_id":114176528,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":8043848,"email":"a***o@outlook.com","display_order":3,"name":"F. Agra","title":"Prevalence of Periodontal Disease, Its Association with Systemic Diseases, and Prevention"}],"downloadable_attachments":[{"id":111674943,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111674943/thumbnails/1.jpg","file_name":"1_Prevalence_of_Periodontal_Disease.pdf","download_url":"https://www.academia.edu/attachments/111674943/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prevalence_of_Periodontal_Disease_Its_As.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111674943/1_Prevalence_of_Periodontal_Disease-libre.pdf?1708492508=\u0026response-content-disposition=attachment%3B+filename%3DPrevalence_of_Periodontal_Disease_Its_As.pdf\u0026Expires=1732758176\u0026Signature=b~5S2bBKs52PrL~vKJXBayBB8SPjPBv96n7ZBz9NJCm~8p5EQ7QRHEW7rzkBcH-MABhuLhp4IGsYE0myI3MehWNEgWuANZ4t1Mk9aUOGcDEvJnpy1QAfrnXh45bZeEk6lUuJ6MveLvG1EoEnpwHF0NryAu9E9o0OrcLKsyn0F-la36HKG-G7SEhse9-XMMzEWX2~8IlOi7Dkfm2HiJwSz7xMrAvppCgKu4deqF6Oe9DSCNTrlMaI5DiY8tkMkXKlMtolchzyWUyK2CrmqFkeqdhPYNzdR4Ym6wYniOycxf6I4Ni1VsaGmP8YPp~9Rdz~8bV1BYfSS82w9eDKm1Cc-Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Prevalence_of_Periodontal_Disease_Its_Association_with_Systemic_Diseases_and_Prevention","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111674943,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111674943/thumbnails/1.jpg","file_name":"1_Prevalence_of_Periodontal_Disease.pdf","download_url":"https://www.academia.edu/attachments/111674943/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prevalence_of_Periodontal_Disease_Its_As.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111674943/1_Prevalence_of_Periodontal_Disease-libre.pdf?1708492508=\u0026response-content-disposition=attachment%3B+filename%3DPrevalence_of_Periodontal_Disease_Its_As.pdf\u0026Expires=1732758176\u0026Signature=b~5S2bBKs52PrL~vKJXBayBB8SPjPBv96n7ZBz9NJCm~8p5EQ7QRHEW7rzkBcH-MABhuLhp4IGsYE0myI3MehWNEgWuANZ4t1Mk9aUOGcDEvJnpy1QAfrnXh45bZeEk6lUuJ6MveLvG1EoEnpwHF0NryAu9E9o0OrcLKsyn0F-la36HKG-G7SEhse9-XMMzEWX2~8IlOi7Dkfm2HiJwSz7xMrAvppCgKu4deqF6Oe9DSCNTrlMaI5DiY8tkMkXKlMtolchzyWUyK2CrmqFkeqdhPYNzdR4Ym6wYniOycxf6I4Ni1VsaGmP8YPp~9Rdz~8bV1BYfSS82w9eDKm1Cc-Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":12733,"name":"Rheumatoid Arthritis","url":"https://www.academia.edu/Documents/in/Rheumatoid_Arthritis"},{"id":24735,"name":"Cardiovascular disease","url":"https://www.academia.edu/Documents/in/Cardiovascular_disease"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":419881,"name":"Oral Hygiene","url":"https://www.academia.edu/Documents/in/Oral_Hygiene"}],"urls":[{"id":39653884,"url":"https://integratedrhd.com/prevalence-of-periodontal-disease-its-association-with-systemic-diseases-and-prevention/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113801044"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113801044/Neuronal_response_in_Alzheimers_and_Parkinsons_disease_the_effect_of_toxic_proteins_on_intracellular_pathways"><img alt="Research paper thumbnail of Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways" class="work-thumbnail" src="https://attachments.academia-assets.com/110669837/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113801044/Neuronal_response_in_Alzheimers_and_Parkinsons_disease_the_effect_of_toxic_proteins_on_intracellular_pathways">Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways</a></div><div class="wp-workCard_item"><span>BMC neuroscience</span><span>, Jan 23, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Accumulation of protein aggregates is the leading cause of cellular dysfunction in neurodegenerat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Accumulation of protein aggregates is the leading cause of cellular dysfunction in neurodegenerative disorders. Alzheimer&#39;s disease (AD), Parkinson&#39;s disease (PD), Huntington&#39;s disease, Prion disease and motor disorders such as amyotrophic lateral sclerosis, present with a similar pattern of progressive neuronal death, nervous system deterioration and cognitive impairment. The common characteristic is an unusual misfolding of proteins which is believed to cause protein deposition and trigger degenerative signals in the neurons. A similar clinical presentation seen in many neurodegenerative disorders suggests the possibility of shared neuronal responses in different disorders. Despite the difference in core elements of deposits in each neurodegenerative disorder, the cascade of neuronal reactions such as activation of glycogen synthase kinase-3 beta, mitogen-activated protein kinases, cell cycle re-entry and oxidative stress leading to a progressive neurodegeneration are ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4f7beb6cb6adf3789440126cfce5d43a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110669837,"asset_id":113801044,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110669837/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113801044"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113801044"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113801044; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113801044]").text(description); $(".js-view-count[data-work-id=113801044]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113801044; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113801044']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113801044, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4f7beb6cb6adf3789440126cfce5d43a" } } $('.js-work-strip[data-work-id=113801044]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113801044,"title":"Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways","translated_title":"","metadata":{"abstract":"Accumulation of protein aggregates is the leading cause of cellular dysfunction in neurodegenerative disorders. Alzheimer\u0026#39;s disease (AD), Parkinson\u0026#39;s disease (PD), Huntington\u0026#39;s disease, Prion disease and motor disorders such as amyotrophic lateral sclerosis, present with a similar pattern of progressive neuronal death, nervous system deterioration and cognitive impairment. The common characteristic is an unusual misfolding of proteins which is believed to cause protein deposition and trigger degenerative signals in the neurons. A similar clinical presentation seen in many neurodegenerative disorders suggests the possibility of shared neuronal responses in different disorders. Despite the difference in core elements of deposits in each neurodegenerative disorder, the cascade of neuronal reactions such as activation of glycogen synthase kinase-3 beta, mitogen-activated protein kinases, cell cycle re-entry and oxidative stress leading to a progressive neurodegeneration are ...","publication_date":{"day":23,"month":1,"year":2015,"errors":{}},"publication_name":"BMC neuroscience"},"translated_abstract":"Accumulation of protein aggregates is the leading cause of cellular dysfunction in neurodegenerative disorders. Alzheimer\u0026#39;s disease (AD), Parkinson\u0026#39;s disease (PD), Huntington\u0026#39;s disease, Prion disease and motor disorders such as amyotrophic lateral sclerosis, present with a similar pattern of progressive neuronal death, nervous system deterioration and cognitive impairment. The common characteristic is an unusual misfolding of proteins which is believed to cause protein deposition and trigger degenerative signals in the neurons. A similar clinical presentation seen in many neurodegenerative disorders suggests the possibility of shared neuronal responses in different disorders. Despite the difference in core elements of deposits in each neurodegenerative disorder, the cascade of neuronal reactions such as activation of glycogen synthase kinase-3 beta, mitogen-activated protein kinases, cell cycle re-entry and oxidative stress leading to a progressive neurodegeneration are ...","internal_url":"https://www.academia.edu/113801044/Neuronal_response_in_Alzheimers_and_Parkinsons_disease_the_effect_of_toxic_proteins_on_intracellular_pathways","translated_internal_url":"","created_at":"2024-01-20T21:06:12.927-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40979549,"work_id":113801044,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":0,"name":"Shohreh Majd","title":"Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways"}],"downloadable_attachments":[{"id":110669837,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110669837/thumbnails/1.jpg","file_name":"s12868-015-0211-1.pdf","download_url":"https://www.academia.edu/attachments/110669837/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Neuronal_response_in_Alzheimers_and_Park.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110669837/s12868-015-0211-1-libre.pdf?1705816913=\u0026response-content-disposition=attachment%3B+filename%3DNeuronal_response_in_Alzheimers_and_Park.pdf\u0026Expires=1732758176\u0026Signature=g-1dx8l6Wygcv1J7Wl3tgozwv5k2Htv7~P9DZ7xVG6GMqM26tfbJdInyFYNTCU8AwjElNszuh1InxIcLsoCdOTHcPaMy4k-vPnEi6WZQHaPPASd9hqGzwlzhAd3RHX0HKI~qfl2oXasNchTAxmgJMsKUdFfYEVYOIcOA-ym0hBtVYtPhPpPlUB9H1HNnOuoIbKYNnsJdz~bZOJpcYumI2Wk4eT1vXek2kA9jgfx8-jGYjSsb2a0kGuHKJAiZKz3oHuide1l-zPoPdCb9JzMTq77LUiNEmErnNiB1S1boUh2D2vaAackoNCk2bXq1l0glutM2u2PwtC8rXZUJ5TcLJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Neuronal_response_in_Alzheimers_and_Parkinsons_disease_the_effect_of_toxic_proteins_on_intracellular_pathways","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":110669837,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110669837/thumbnails/1.jpg","file_name":"s12868-015-0211-1.pdf","download_url":"https://www.academia.edu/attachments/110669837/download_file?st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Neuronal_response_in_Alzheimers_and_Park.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110669837/s12868-015-0211-1-libre.pdf?1705816913=\u0026response-content-disposition=attachment%3B+filename%3DNeuronal_response_in_Alzheimers_and_Park.pdf\u0026Expires=1732758176\u0026Signature=g-1dx8l6Wygcv1J7Wl3tgozwv5k2Htv7~P9DZ7xVG6GMqM26tfbJdInyFYNTCU8AwjElNszuh1InxIcLsoCdOTHcPaMy4k-vPnEi6WZQHaPPASd9hqGzwlzhAd3RHX0HKI~qfl2oXasNchTAxmgJMsKUdFfYEVYOIcOA-ym0hBtVYtPhPpPlUB9H1HNnOuoIbKYNnsJdz~bZOJpcYumI2Wk4eT1vXek2kA9jgfx8-jGYjSsb2a0kGuHKJAiZKz3oHuide1l-zPoPdCb9JzMTq77LUiNEmErnNiB1S1boUh2D2vaAackoNCk2bXq1l0glutM2u2PwtC8rXZUJ5TcLJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience"},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":3971,"name":"Protein Folding","url":"https://www.academia.edu/Documents/in/Protein_Folding"},{"id":22764,"name":"Neurodegeneration","url":"https://www.academia.edu/Documents/in/Neurodegeneration"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":40538,"name":"Alpha Synuclein","url":"https://www.academia.edu/Documents/in/Alpha_Synuclein"},{"id":42973,"name":"Amyotrophic Lateral Sclerosis","url":"https://www.academia.edu/Documents/in/Amyotrophic_Lateral_Sclerosis"},{"id":125522,"name":"Neurotoxicity","url":"https://www.academia.edu/Documents/in/Neurotoxicity"},{"id":1120234,"name":"Alzheimer Disease","url":"https://www.academia.edu/Documents/in/Alzheimer_Disease"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1541077,"name":"Parkinson Disease","url":"https://www.academia.edu/Documents/in/Parkinson_Disease"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113317194"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113317194/Alzheimer_s_Disease_and_Cancer_When_Two_Monsters_Cannot_Be_Together"><img alt="Research paper thumbnail of Alzheimer’s Disease and Cancer: When Two Monsters Cannot Be Together" class="work-thumbnail" src="https://attachments.academia-assets.com/110307608/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113317194/Alzheimer_s_Disease_and_Cancer_When_Two_Monsters_Cannot_Be_Together">Alzheimer’s Disease and Cancer: When Two Monsters Cannot Be Together</a></div><div class="wp-workCard_item"><span>Frontiers in Neuroscience</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1287009ae13086edb534035ae0214786" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110307608,"asset_id":113317194,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110307608/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113317194"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113317194"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113317194; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113317194]").text(description); $(".js-view-count[data-work-id=113317194]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113317194; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113317194']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113317194, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1287009ae13086edb534035ae0214786" } } $('.js-work-strip[data-work-id=113317194]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113317194,"title":"Alzheimer’s Disease and Cancer: When Two Monsters Cannot Be Together","translated_title":"","metadata":{"publisher":"Frontiers Media SA","grobid_abstract":"Alzheimer's disease (AD) and cancer are among the leading causes of human death around the world. While neurodegeneration is the main feature of AD, the most important characteristic of malignant tumors is cell proliferation, placing these two diseases in opposite sides of cell division spectrum. Interestingly, AD and cancer's pathologies consist of a remarkable common feature and that is the presence of active cell cycle in both conditions. In an in vitro model of primary adult neuronal culture, we previously showed that treating cell with beta amyloid forced neurons to start a cell cycle. Instead of cell division, however, neuronal cell cycle was aborted and a massive neurodegeneration was left behind as the consequence. A high level of cell cycle entry, which is a requirement for cancer pathogenesis, was reported in clinically diagnosed cases of AD, leading to neurodegeneration. The diverse clinical manifestation of a similar etiology, have puzzled researchers for many years. In fact, the evidence showed an inverse association between AD and cancer prevalence, suggesting that switching pathogenesis toward AD protects patients against cancer and vice versa. In this mini review, we discussed the possibility of involvement of cell proliferation and survival dysregulation as the underlying mechanism of neurodegeneration in AD, and the leading event to develop both disorders' pathology. As examples, the role of phosphoinositide 3 kinase/Akt/ mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway in cell cycle re-entry and blocking autophagy are discussed as potential common intracellular components between AD and cancer pathogenesis, with diverse clinical diagnosis.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"Frontiers in Neuroscience","grobid_abstract_attachment_id":110307608},"translated_abstract":null,"internal_url":"https://www.academia.edu/113317194/Alzheimer_s_Disease_and_Cancer_When_Two_Monsters_Cannot_Be_Together","translated_internal_url":"","created_at":"2024-01-10T23:46:29.517-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40920231,"work_id":113317194,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":0,"name":"Shohreh Majd","title":"Alzheimer’s Disease and Cancer: When Two Monsters Cannot Be Together"}],"downloadable_attachments":[{"id":110307608,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110307608/thumbnails/1.jpg","file_name":"7b9d9497ba51e2f5d33f62e96a94eb93a614.pdf","download_url":"https://www.academia.edu/attachments/110307608/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alzheimer_s_Disease_and_Cancer_When_Two.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110307608/7b9d9497ba51e2f5d33f62e96a94eb93a614-libre.pdf?1704960434=\u0026response-content-disposition=attachment%3B+filename%3DAlzheimer_s_Disease_and_Cancer_When_Two.pdf\u0026Expires=1732758177\u0026Signature=QOZz4CCcTt1OBpCJ3J4uQADTdlgQ27RXPi0otr69NtanE6WNj0w6QsYvlKzic~JxED5LqKLhWl3xD8FFspl5bZS2jNWZ9hNsbLtXbjHkBH6h-FIm-Dt7PqXPvaT8eR7wu0H5GCKC-~YSXaSJQbrqbPu7WFypbrBYxHT4EvtIRfIuts0qlDFeF29M2CZLXjPu6zcnaLwtz9-AwQifedifgEI4OIBzjyEsrgdxQvnkc4Oc1dk9JRe0U-8r~xn3PhbdcoXw2Rrx8wCSSJ6alduxiv9ZAx31vgEZkUt6SHkCx2BCutgG3hekboiE9MV-CEvPYDUfkYOlapZrEP3AArS8Bg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Alzheimer_s_Disease_and_Cancer_When_Two_Monsters_Cannot_Be_Together","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":110307608,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110307608/thumbnails/1.jpg","file_name":"7b9d9497ba51e2f5d33f62e96a94eb93a614.pdf","download_url":"https://www.academia.edu/attachments/110307608/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alzheimer_s_Disease_and_Cancer_When_Two.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110307608/7b9d9497ba51e2f5d33f62e96a94eb93a614-libre.pdf?1704960434=\u0026response-content-disposition=attachment%3B+filename%3DAlzheimer_s_Disease_and_Cancer_When_Two.pdf\u0026Expires=1732758177\u0026Signature=QOZz4CCcTt1OBpCJ3J4uQADTdlgQ27RXPi0otr69NtanE6WNj0w6QsYvlKzic~JxED5LqKLhWl3xD8FFspl5bZS2jNWZ9hNsbLtXbjHkBH6h-FIm-Dt7PqXPvaT8eR7wu0H5GCKC-~YSXaSJQbrqbPu7WFypbrBYxHT4EvtIRfIuts0qlDFeF29M2CZLXjPu6zcnaLwtz9-AwQifedifgEI4OIBzjyEsrgdxQvnkc4Oc1dk9JRe0U-8r~xn3PhbdcoXw2Rrx8wCSSJ6alduxiv9ZAx31vgEZkUt6SHkCx2BCutgG3hekboiE9MV-CEvPYDUfkYOlapZrEP3AArS8Bg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience"},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":9113,"name":"Cell Cycle","url":"https://www.academia.edu/Documents/in/Cell_Cycle"},{"id":22764,"name":"Neurodegeneration","url":"https://www.academia.edu/Documents/in/Neurodegeneration"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":295271,"name":"Protein kinase B","url":"https://www.academia.edu/Documents/in/Protein_kinase_B"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":38448412,"url":"https://www.frontiersin.org/article/10.3389/fnins.2019.00155/full"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112062765"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112062765/The_impact_of_tau_hyperphosphorylation_at_Ser_262_on_memory_and_learning_after_global_brain_ischaemia_in_a_rat_model_of_reversible_cardiac_arrest"><img alt="Research paper thumbnail of The impact of tau hyperphosphorylation at Ser 262 on memory and learning after global brain ischaemia in a rat model of reversible cardiac arrest" class="work-thumbnail" src="https://attachments.academia-assets.com/109409879/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112062765/The_impact_of_tau_hyperphosphorylation_at_Ser_262_on_memory_and_learning_after_global_brain_ischaemia_in_a_rat_model_of_reversible_cardiac_arrest">The impact of tau hyperphosphorylation at Ser 262 on memory and learning after global brain ischaemia in a rat model of reversible cardiac arrest</a></div><div class="wp-workCard_item"><span>IBRO Reports</span><span>, 2017</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e81603cb9ab5dc82b840cbe7ef973668" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109409879,"asset_id":112062765,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109409879/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112062765"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112062765"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112062765; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112062765]").text(description); $(".js-view-count[data-work-id=112062765]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112062765; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112062765']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112062765, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e81603cb9ab5dc82b840cbe7ef973668" } } $('.js-work-strip[data-work-id=112062765]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112062765,"title":"The impact of tau hyperphosphorylation at Ser 262 on memory and learning after global brain ischaemia in a rat model of reversible cardiac arrest","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"The impact of tau hyperphosphorylation at Ser²⁶² on memory and learning after global brain ischaemia in a rat model of reversible cardiac arrest","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"IBRO Reports","grobid_abstract_attachment_id":109409879},"translated_abstract":null,"internal_url":"https://www.academia.edu/112062765/The_impact_of_tau_hyperphosphorylation_at_Ser_262_on_memory_and_learning_after_global_brain_ischaemia_in_a_rat_model_of_reversible_cardiac_arrest","translated_internal_url":"","created_at":"2023-12-22T03:27:48.668-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":109409879,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109409879/thumbnails/1.jpg","file_name":"hdl_109318.pdf","download_url":"https://www.academia.edu/attachments/109409879/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_impact_of_tau_hyperphosphorylation_a.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109409879/hdl_109318-libre.pdf?1703247340=\u0026response-content-disposition=attachment%3B+filename%3DThe_impact_of_tau_hyperphosphorylation_a.pdf\u0026Expires=1732758177\u0026Signature=A5RIFhNFW3A9o0vRddz9QcPWXyZjlvXqopdGcvLnX0-X~VAGjXECFBADtTqexH0Wzk5gen~uvahr77b0zLU3bbjVvmkHYxoRTtd9XIV8lzts6loo-t8Pwnqc98SFj1yQlPtdSoMg95BegOrZcmelEefgF3ZpLVIHgm99H8aXFNHSIAzVWWcxF-TYdYzsL5CBeNnWzHdSlgTvC~55Fh6t2F9kJqBlYiUkyd4vrhQ-0acKKBKlIJu6F-TLYojMmizKhSLjG4GnA~9VajRUSc98MuRF9a3yPK8hWiYkYbgmNDXdFJwftdcmAnq-qW05iKhbq9QY2WpT0z-8KX~97IKysg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_impact_of_tau_hyperphosphorylation_at_Ser_262_on_memory_and_learning_after_global_brain_ischaemia_in_a_rat_model_of_reversible_cardiac_arrest","translated_slug":"","page_count":14,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":109409879,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109409879/thumbnails/1.jpg","file_name":"hdl_109318.pdf","download_url":"https://www.academia.edu/attachments/109409879/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_impact_of_tau_hyperphosphorylation_a.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109409879/hdl_109318-libre.pdf?1703247340=\u0026response-content-disposition=attachment%3B+filename%3DThe_impact_of_tau_hyperphosphorylation_a.pdf\u0026Expires=1732758177\u0026Signature=A5RIFhNFW3A9o0vRddz9QcPWXyZjlvXqopdGcvLnX0-X~VAGjXECFBADtTqexH0Wzk5gen~uvahr77b0zLU3bbjVvmkHYxoRTtd9XIV8lzts6loo-t8Pwnqc98SFj1yQlPtdSoMg95BegOrZcmelEefgF3ZpLVIHgm99H8aXFNHSIAzVWWcxF-TYdYzsL5CBeNnWzHdSlgTvC~55Fh6t2F9kJqBlYiUkyd4vrhQ-0acKKBKlIJu6F-TLYojMmizKhSLjG4GnA~9VajRUSc98MuRF9a3yPK8hWiYkYbgmNDXdFJwftdcmAnq-qW05iKhbq9QY2WpT0z-8KX~97IKysg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":81065,"name":"Phosphatase","url":"https://www.academia.edu/Documents/in/Phosphatase"},{"id":172083,"name":"Phosphorylation","url":"https://www.academia.edu/Documents/in/Phosphorylation"},{"id":172084,"name":"AMPK","url":"https://www.academia.edu/Documents/in/AMPK"},{"id":223869,"name":"Protein Phosphatase 2A","url":"https://www.academia.edu/Documents/in/Protein_Phosphatase_2A"},{"id":247490,"name":"Kinase","url":"https://www.academia.edu/Documents/in/Kinase"},{"id":2928105,"name":"Tau protein","url":"https://www.academia.edu/Documents/in/Tau_protein"}],"urls":[{"id":37563984,"url":"https://api.elsevier.com/content/article/PII:S2451830116300243?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111374869"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111374869/Clinical_Features_of_Coronavirus_Infection_An_Updated_Review"><img alt="Research paper thumbnail of Clinical Features of Coronavirus Infection: An Updated Review" class="work-thumbnail" src="https://attachments.academia-assets.com/111674700/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111374869/Clinical_Features_of_Coronavirus_Infection_An_Updated_Review">Clinical Features of Coronavirus Infection: An Updated Review</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The coronavirus (CoV) family, particularly severe acute respiratory syndrome coronavirus 2 (SARS-...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The coronavirus (CoV) family, particularly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has garnered global attention due to the ongoing coronavirus disease 2019 (COVID-19) pandemic. This review article aims to provide an up-to-date overview of the clinical features associated with coronavirus infections. Here we explore the diverse manifestations of the disease, ranging from mild respiratory symptoms to severe respiratory distress and multi-organ dysfunction. Additionally, we discuss the latest advancements in our understanding of the clinical spectrum, risk factors, and long-term sequelae associated with COVID-19.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fbb296d0ef382ff0be777563f014abb8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111674700,"asset_id":111374869,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111674700/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111374869"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111374869"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111374869; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111374869]").text(description); $(".js-view-count[data-work-id=111374869]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111374869; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111374869']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111374869, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fbb296d0ef382ff0be777563f014abb8" } } $('.js-work-strip[data-work-id=111374869]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111374869,"title":"Clinical Features of Coronavirus Infection: An Updated Review","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685879","issue":"2","volume":"1","abstract":"The coronavirus (CoV) family, particularly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has garnered global attention due to the ongoing coronavirus disease 2019 (COVID-19) pandemic. This review article aims to provide an up-to-date overview of the clinical features associated with coronavirus infections. Here we explore the diverse manifestations of the disease, ranging from mild respiratory symptoms to severe respiratory distress and multi-organ dysfunction. Additionally, we discuss the latest advancements in our understanding of the clinical spectrum, risk factors, and long-term sequelae associated with COVID-19.","page_numbers":"32-38","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"The coronavirus (CoV) family, particularly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has garnered global attention due to the ongoing coronavirus disease 2019 (COVID-19) pandemic. This review article aims to provide an up-to-date overview of the clinical features associated with coronavirus infections. Here we explore the diverse manifestations of the disease, ranging from mild respiratory symptoms to severe respiratory distress and multi-organ dysfunction. Additionally, we discuss the latest advancements in our understanding of the clinical spectrum, risk factors, and long-term sequelae associated with COVID-19.","internal_url":"https://www.academia.edu/111374869/Clinical_Features_of_Coronavirus_Infection_An_Updated_Review","translated_internal_url":"","created_at":"2023-12-13T21:05:38.510-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40712286,"work_id":111374869,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":1,"name":"Shohreh Majd","title":"Clinical Features of Coronavirus Infection: An Updated Review"},{"id":40712285,"work_id":111374869,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":7989393,"email":"d***i@gmail.com","display_order":10,"name":"Li Y","title":"Clinical Features of Coronavirus Infection: An Updated Review"}],"downloadable_attachments":[{"id":111674700,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111674700/thumbnails/1.jpg","file_name":"6_Clinical_Features_of_Coronavirus_Infection_An_Updated_Review.pdf","download_url":"https://www.academia.edu/attachments/111674700/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_Features_of_Coronavirus_Infecti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111674700/6_Clinical_Features_of_Coronavirus_Infection_An_Updated_Review-libre.pdf?1708492550=\u0026response-content-disposition=attachment%3B+filename%3DClinical_Features_of_Coronavirus_Infecti.pdf\u0026Expires=1732758177\u0026Signature=Hcr52y9kx~LstXY8LG9u0H6n6VphlEqC7Y2rOVW~bMTtNOZVj3Ja2Dp6UUR5WuC1ZN-8VTtH33zHUymubcnBsTvcIzcnhZdDvkysZWoPPcjezzI9Rdp356bmKz6pYSXzpZr04aHohiaucH9ir5NCXqgDEyAw8Ai6rGVaFCe49ijC7bMqBYbPcW0h2kHtOa-EPgW9YZBzxLMabyUDz0FN2eyUqV3aGWmLOq1v1xMx8UKXQL1GuhbFAPHrVRShzFYvdPZR~Cdg-e-QHyvE1lkpXrMQNOe-A-X1M1YKRyBITqEnErlWMZjMKAY8Lxh~J5XlxPED7IGhw~GD27JcL5gzIw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Clinical_Features_of_Coronavirus_Infection_An_Updated_Review","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111674700,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111674700/thumbnails/1.jpg","file_name":"6_Clinical_Features_of_Coronavirus_Infection_An_Updated_Review.pdf","download_url":"https://www.academia.edu/attachments/111674700/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_Features_of_Coronavirus_Infecti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111674700/6_Clinical_Features_of_Coronavirus_Infection_An_Updated_Review-libre.pdf?1708492550=\u0026response-content-disposition=attachment%3B+filename%3DClinical_Features_of_Coronavirus_Infecti.pdf\u0026Expires=1732758177\u0026Signature=Hcr52y9kx~LstXY8LG9u0H6n6VphlEqC7Y2rOVW~bMTtNOZVj3Ja2Dp6UUR5WuC1ZN-8VTtH33zHUymubcnBsTvcIzcnhZdDvkysZWoPPcjezzI9Rdp356bmKz6pYSXzpZr04aHohiaucH9ir5NCXqgDEyAw8Ai6rGVaFCe49ijC7bMqBYbPcW0h2kHtOa-EPgW9YZBzxLMabyUDz0FN2eyUqV3aGWmLOq1v1xMx8UKXQL1GuhbFAPHrVRShzFYvdPZR~Cdg-e-QHyvE1lkpXrMQNOe-A-X1M1YKRyBITqEnErlWMZjMKAY8Lxh~J5XlxPED7IGhw~GD27JcL5gzIw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health"},{"id":17960,"name":"Infectious Diseases","url":"https://www.academia.edu/Documents/in/Infectious_Diseases"},{"id":385972,"name":"Immunocompromised host","url":"https://www.academia.edu/Documents/in/Immunocompromised_host"}],"urls":[{"id":39653668,"url":"https://integratedrhd.com/2023-12-p27-31-2/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111290830"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111290830/A_comparison_of_LKB1_AMPK_mTOR_metabolic_axis_response_to_global_ischaemia_in_brain_heart_liver_and_kidney_in_a_rat_model_of_cardiac_arrest"><img alt="Research paper thumbnail of A comparison of LKB1/AMPK/mTOR metabolic axis response to global ischaemia in brain, heart, liver and kidney in a rat model of cardiac arrest" class="work-thumbnail" src="https://attachments.academia-assets.com/108869647/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111290830/A_comparison_of_LKB1_AMPK_mTOR_metabolic_axis_response_to_global_ischaemia_in_brain_heart_liver_and_kidney_in_a_rat_model_of_cardiac_arrest">A comparison of LKB1/AMPK/mTOR metabolic axis response to global ischaemia in brain, heart, liver and kidney in a rat model of cardiac arrest</a></div><div class="wp-workCard_item"><span>BMC Cell Biology</span><span>, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ce03e8d99fd34735621fcf89373c52af" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108869647,"asset_id":111290830,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108869647/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111290830"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111290830"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111290830; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111290830]").text(description); $(".js-view-count[data-work-id=111290830]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111290830; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111290830']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111290830, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ce03e8d99fd34735621fcf89373c52af" } } $('.js-work-strip[data-work-id=111290830]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111290830,"title":"A comparison of LKB1/AMPK/mTOR metabolic axis response to global ischaemia in brain, heart, liver and kidney in a rat model of cardiac arrest","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","grobid_abstract":"Background: Cellular energy failure in high metabolic rate organs is one of the underlying causes for many disorders such as neurodegenerative diseases, cardiomyopathies, liver and renal failures. In the past decade, numerous studies have discovered the cellular axis of LKB1/AMPK/mTOR as an essential modulator of cell homeostasis in response to energy stress. Through regulating adaptive mechanisms, this axis adjusts the energy availability to its demand by a systematized control on metabolism. Energy stress, however, could be sensed at different levels in various tissues, leading to applying different strategies in response to hypoxic insults. Methods: Here the immediate strategies of high metabolic rate organs to time-dependent short episodes of ischaemia were studied by using a rat model (n = 6/group) of cardiac arrest (CA) (15 and 30 s, 1, 2, 4 and 8 min CA). Using western blot analysis, we examined the responses of LKB1/AMPK/mTOR pathway in brain, heart, liver and kidney from 15 s up to 8 min of global ischaemia. The ratio of ADP/ATP was assessed in all ischemic and control groups, using ApoSENSOR bioluminescent assay kit. Results: Brain, followed by kidney showed the early dephosphorylation response in AMPK (Thr 172) and LKB1 (Ser 431); in the absence of ATP decline (ADP/ATP elevation). Dephosphorylation of AMPK was followed by rephosphorylation and hyperphosphorylation, which was associated with a significant ATP decline. While heart's activity of AMPK and LKB1 remained at the same level during short episodes of ischaemia, liver's LKB1 was dephosphorylated after 2 min. AMPK response to ischaemia in liver was mainly based on an early alternative and a late constant hyperphosphorylation. No significant changes was observed in mTOR activity in all groups. Conclusion: Together our results suggest that early AMPK dephosphorylation followed by late hyperphosphorylation is the strategy of brain and kidney in response to ischaemia. While the liver seemed to get benefit of its AMPK system in early ischameia, possibly to stabilize ATP, the level of LKB1/AMPK activity in heart remained unchanged in short ischaemic episodes up to 8 min. Further researches must be conducted to elucidate the molecular mechanism underlying LKB1/AMPK response to oxygen supply.","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"BMC Cell Biology","grobid_abstract_attachment_id":108869647},"translated_abstract":null,"internal_url":"https://www.academia.edu/111290830/A_comparison_of_LKB1_AMPK_mTOR_metabolic_axis_response_to_global_ischaemia_in_brain_heart_liver_and_kidney_in_a_rat_model_of_cardiac_arrest","translated_internal_url":"","created_at":"2023-12-12T22:24:28.897-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":108869647,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108869647/thumbnails/1.jpg","file_name":"s12860-018-0159-y.pdf","download_url":"https://www.academia.edu/attachments/108869647/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_comparison_of_LKB1_AMPK_mTOR_metabolic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108869647/s12860-018-0159-y-libre.pdf?1702452247=\u0026response-content-disposition=attachment%3B+filename%3DA_comparison_of_LKB1_AMPK_mTOR_metabolic.pdf\u0026Expires=1732758177\u0026Signature=VGBi1og~7K2m~zuWluBPH0wUK1TX8CY7n7iYKTkZlzpTM4azf21bQLI30wHSUZNEkTNDTU87Phusc3U~Z8ysaHlUWznlVwS49iMrPyUQ1kIvNXeIsmoxTAMEuphkzdIINaZkVqM2I4a-T9ywjE7alcfkOjxq3ld2EAn8OHAIJ3bntvd3QKuqL73pKHEnWN8MA5b3oqc5VuH~Q~WxFT3p8fnFvbfTdHKh2drV3pSUysRcPjv1rfJYTBrjGHY33klk6yejf8IEkQsfPAxGrQZlxRmewlckVgSmOxS5jnpz5yuik5hos0B3sG2~qMRbmpPIavcVYQUUMqztFovMx7Typg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_comparison_of_LKB1_AMPK_mTOR_metabolic_axis_response_to_global_ischaemia_in_brain_heart_liver_and_kidney_in_a_rat_model_of_cardiac_arrest","translated_slug":"","page_count":12,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":108869647,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108869647/thumbnails/1.jpg","file_name":"s12860-018-0159-y.pdf","download_url":"https://www.academia.edu/attachments/108869647/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_comparison_of_LKB1_AMPK_mTOR_metabolic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108869647/s12860-018-0159-y-libre.pdf?1702452247=\u0026response-content-disposition=attachment%3B+filename%3DA_comparison_of_LKB1_AMPK_mTOR_metabolic.pdf\u0026Expires=1732758177\u0026Signature=VGBi1og~7K2m~zuWluBPH0wUK1TX8CY7n7iYKTkZlzpTM4azf21bQLI30wHSUZNEkTNDTU87Phusc3U~Z8ysaHlUWznlVwS49iMrPyUQ1kIvNXeIsmoxTAMEuphkzdIINaZkVqM2I4a-T9ywjE7alcfkOjxq3ld2EAn8OHAIJ3bntvd3QKuqL73pKHEnWN8MA5b3oqc5VuH~Q~WxFT3p8fnFvbfTdHKh2drV3pSUysRcPjv1rfJYTBrjGHY33klk6yejf8IEkQsfPAxGrQZlxRmewlckVgSmOxS5jnpz5yuik5hos0B3sG2~qMRbmpPIavcVYQUUMqztFovMx7Typg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":108869646,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108869646/thumbnails/1.jpg","file_name":"s12860-018-0159-y.pdf","download_url":"https://www.academia.edu/attachments/108869646/download_file","bulk_download_file_name":"A_comparison_of_LKB1_AMPK_mTOR_metabolic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108869646/s12860-018-0159-y-libre.pdf?1702452250=\u0026response-content-disposition=attachment%3B+filename%3DA_comparison_of_LKB1_AMPK_mTOR_metabolic.pdf\u0026Expires=1732758177\u0026Signature=I~GKygN7hwACAFr2siFpgSnhVMm0Ma5DNOwMq4d11A8qxhTS6M3iU7~lYwg~jhjLZKdy-SZERr3QVE1AQVJOYuioOQzSB6cJkwWNmlSvsBg3U5D48-EZH13ojGgcxciyXv0RXOophRlw41XQh45i5GEzJ5tQaQCAr6yaxF9wRE0kXfu7w2TylEPqnz1~mWcegIhS7QNpeGYSIz3KbHqBpdKS~rj2atTZ5xPLmIMArwfB8kHocIEphny8WqAsqgv6JxqR1L1Y38CEFkSGhzyowF4hJluj~X0KJuqxklm8k-t2qJiRTOgz9NSa00bAnThRO-s6AR8eWdWzmJrPB00m9Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":61235,"name":"Cardiac arrest","url":"https://www.academia.edu/Documents/in/Cardiac_arrest"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":82983,"name":"Ischemia","url":"https://www.academia.edu/Documents/in/Ischemia"},{"id":91391,"name":"mTOR","url":"https://www.academia.edu/Documents/in/mTOR"},{"id":172084,"name":"AMPK","url":"https://www.academia.edu/Documents/in/AMPK"},{"id":462111,"name":"Western blot","url":"https://www.academia.edu/Documents/in/Western_blot"},{"id":465842,"name":"Ischaemia","url":"https://www.academia.edu/Documents/in/Ischaemia"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":1953129,"name":"Dephosphorylation","url":"https://www.academia.edu/Documents/in/Dephosphorylation"}],"urls":[{"id":36990827,"url":"http://link.springer.com/content/pdf/10.1186/s12860-018-0159-y.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110602069"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110602069/Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis"><img alt="Research paper thumbnail of Decoding the Intricate Roles of Vitamin D in Bone Health: Beyond Calcium Homeostasis" class="work-thumbnail" src="https://attachments.academia-assets.com/111674248/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110602069/Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis">Decoding the Intricate Roles of Vitamin D in Bone Health: Beyond Calcium Homeostasis</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The intricate relationship between vitamin D and bone health encompasses a diverse spectrum of ro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The intricate relationship between vitamin D and bone health encompasses a diverse spectrum of roles, extending far beyond its classical functions in calcium homeostasis. Apart from the classical role of vitamin D in maintaining calcium homeostasis, it involves in intricate intracellular processes that contribute significantly to bone health. This includes modulation of oxidative stress, with vitamin D receptors in osteoblasts and osteoclasts regulating antioxidant enzymes, safeguarding bone cells from oxidative damage. Vitamin D's influence extends to energy metabolism, impacting adipocytes and muscle cells directly. Deficiency is associated with increased adiposity and altered muscle function, emphasizing its regulatory role in adipogenesis, lipolysis, and muscle protein synthesis. This intricate interplay highlights vitamin D's expanded role beyond calcium homeostasis. Vitamin D also emerges as a crucial regulator in promoting the anabolic state of bone. It enhances osteoblast differentiation and mineralization through intricate signalling pathways, ensuring proper bone formation. Simultaneously, it modulates the expression of growth factors and cytokines, promoting bone formation while inhibiting factors associated with bone resorption. Here we explore the multifaceted impact of vitamin D on bone and its role in preserving skeletal integrity. The review extends to discuss the preventive role of vitamin D in the catabolic state of bone, where bone resorption surpasses formation. Vitamin D's regulatory control over factors such as RANKL and OPG plays a pivotal role in maintaining skeletal integrity, preventing bone loss.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7b3e3c8ce95e8e42d13df8ca5b2b4adf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111674248,"asset_id":110602069,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111674248/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110602069"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110602069"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110602069; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110602069]").text(description); $(".js-view-count[data-work-id=110602069]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110602069; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110602069']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110602069, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7b3e3c8ce95e8e42d13df8ca5b2b4adf" } } $('.js-work-strip[data-work-id=110602069]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110602069,"title":"Decoding the Intricate Roles of Vitamin D in Bone Health: Beyond Calcium Homeostasis","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685856","issue":"2","volume":"1","abstract":"The intricate relationship between vitamin D and bone health encompasses a diverse spectrum of roles, extending far beyond its classical functions in calcium homeostasis. Apart from the classical role of vitamin D in maintaining calcium homeostasis, it involves in intricate intracellular processes that contribute significantly to bone health. This includes modulation of oxidative stress, with vitamin D receptors in osteoblasts and osteoclasts regulating antioxidant enzymes, safeguarding bone cells from oxidative damage. Vitamin D's influence extends to energy metabolism, impacting adipocytes and muscle cells directly. Deficiency is associated with increased adiposity and altered muscle function, emphasizing its regulatory role in adipogenesis, lipolysis, and muscle protein synthesis. This intricate interplay highlights vitamin D's expanded role beyond calcium homeostasis. Vitamin D also emerges as a crucial regulator in promoting the anabolic state of bone. It enhances osteoblast differentiation and mineralization through intricate signalling pathways, ensuring proper bone formation. Simultaneously, it modulates the expression of growth factors and cytokines, promoting bone formation while inhibiting factors associated with bone resorption. Here we explore the multifaceted impact of vitamin D on bone and its role in preserving skeletal integrity. The review extends to discuss the preventive role of vitamin D in the catabolic state of bone, where bone resorption surpasses formation. Vitamin D's regulatory control over factors such as RANKL and OPG plays a pivotal role in maintaining skeletal integrity, preventing bone loss.","ai_title_tag":"Vitamin D's Multifaceted Role in Bone Health and Integrity","page_numbers":"27-31","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"The intricate relationship between vitamin D and bone health encompasses a diverse spectrum of roles, extending far beyond its classical functions in calcium homeostasis. Apart from the classical role of vitamin D in maintaining calcium homeostasis, it involves in intricate intracellular processes that contribute significantly to bone health. This includes modulation of oxidative stress, with vitamin D receptors in osteoblasts and osteoclasts regulating antioxidant enzymes, safeguarding bone cells from oxidative damage. Vitamin D's influence extends to energy metabolism, impacting adipocytes and muscle cells directly. Deficiency is associated with increased adiposity and altered muscle function, emphasizing its regulatory role in adipogenesis, lipolysis, and muscle protein synthesis. This intricate interplay highlights vitamin D's expanded role beyond calcium homeostasis. Vitamin D also emerges as a crucial regulator in promoting the anabolic state of bone. It enhances osteoblast differentiation and mineralization through intricate signalling pathways, ensuring proper bone formation. Simultaneously, it modulates the expression of growth factors and cytokines, promoting bone formation while inhibiting factors associated with bone resorption. Here we explore the multifaceted impact of vitamin D on bone and its role in preserving skeletal integrity. The review extends to discuss the preventive role of vitamin D in the catabolic state of bone, where bone resorption surpasses formation. Vitamin D's regulatory control over factors such as RANKL and OPG plays a pivotal role in maintaining skeletal integrity, preventing bone loss.","internal_url":"https://www.academia.edu/110602069/Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis","translated_internal_url":"","created_at":"2023-12-04T23:40:49.911-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40648050,"work_id":110602069,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":7976704,"email":"g***2@gmail.com","display_order":4,"name":"Sharma Kaur","title":"Decoding the Intricate Roles of Vitamin D in Bone Health: Beyond Calcium Homeostasis"}],"downloadable_attachments":[{"id":111674248,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111674248/thumbnails/1.jpg","file_name":"5_Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis.pdf","download_url":"https://www.academia.edu/attachments/111674248/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Decoding_the_Intricate_Roles_of_Vitamin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111674248/5_Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis-libre.pdf?1708492615=\u0026response-content-disposition=attachment%3B+filename%3DDecoding_the_Intricate_Roles_of_Vitamin.pdf\u0026Expires=1732758177\u0026Signature=JMaKueGEOPTFhVfWzeEnLthVhJFsmVKMqIQNiQl5JwtRCK5yub3xM8WpCVMOggy0W1lIB4-jCguJz9wYC8cs1qaJLaurxBjwhEW4hCr2LzQf3s1TiV06G6W224xqGK3PZx0JbPOmVTfSG2cLQI93xO-5JR0E~yFjqL8GgQuEtURgsJ2E5xOkr7GsWHpx4c2u2nOzw5KuNewXusoQV7P6O5rZDTR22Ui5f7skN5NGwy1PFySAi3jY7QYuVNRoSyY4duff1-V5FrzSkV9b7rwdGDf20W4aiFxbuXRGkZl6lfJ8hVCYvT-zv8~wgsadn6-HGjb7Opg8rVEK1iTGvSV--w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111674248,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111674248/thumbnails/1.jpg","file_name":"5_Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis.pdf","download_url":"https://www.academia.edu/attachments/111674248/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Decoding_the_Intricate_Roles_of_Vitamin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111674248/5_Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis-libre.pdf?1708492615=\u0026response-content-disposition=attachment%3B+filename%3DDecoding_the_Intricate_Roles_of_Vitamin.pdf\u0026Expires=1732758177\u0026Signature=JMaKueGEOPTFhVfWzeEnLthVhJFsmVKMqIQNiQl5JwtRCK5yub3xM8WpCVMOggy0W1lIB4-jCguJz9wYC8cs1qaJLaurxBjwhEW4hCr2LzQf3s1TiV06G6W224xqGK3PZx0JbPOmVTfSG2cLQI93xO-5JR0E~yFjqL8GgQuEtURgsJ2E5xOkr7GsWHpx4c2u2nOzw5KuNewXusoQV7P6O5rZDTR22Ui5f7skN5NGwy1PFySAi3jY7QYuVNRoSyY4duff1-V5FrzSkV9b7rwdGDf20W4aiFxbuXRGkZl6lfJ8hVCYvT-zv8~wgsadn6-HGjb7Opg8rVEK1iTGvSV--w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1040,"name":"Food Science","url":"https://www.academia.edu/Documents/in/Food_Science"},{"id":9531,"name":"Vitamin D","url":"https://www.academia.edu/Documents/in/Vitamin_D"},{"id":10221,"name":"Food and Nutrition","url":"https://www.academia.edu/Documents/in/Food_and_Nutrition"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":36213,"name":"Energy Metabolism","url":"https://www.academia.edu/Documents/in/Energy_Metabolism"},{"id":70883,"name":"Bone health","url":"https://www.academia.edu/Documents/in/Bone_health"}],"urls":[{"id":39653264,"url":"https://integratedrhd.com/2023-12-p27-31/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110598756"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110598756/Optimizing_Healthcare_Project_Management_with_Positive_Psychology"><img alt="Research paper thumbnail of Optimizing Healthcare Project Management with Positive Psychology" class="work-thumbnail" src="https://attachments.academia-assets.com/111672546/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110598756/Optimizing_Healthcare_Project_Management_with_Positive_Psychology">Optimizing Healthcare Project Management with Positive Psychology</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">As healthcare organizations navigate the complexities of the industry, project managers play a ce...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">As healthcare organizations navigate the complexities of the industry, project managers play a central role in optimizing patient care and operational processes. In such dynamic setting, positive psychology emerges as a paradigm, offering a holistic framework that extends beyond traditional project management methodologies. Recent advancements in positive psychology research highlight its applicability across various professional domains and healthcare sector is not an exception.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6a1a563c5940cb5b2e95313c49192b58" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111672546,"asset_id":110598756,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111672546/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110598756"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110598756"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110598756; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110598756]").text(description); $(".js-view-count[data-work-id=110598756]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110598756; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110598756']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110598756, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6a1a563c5940cb5b2e95313c49192b58" } } $('.js-work-strip[data-work-id=110598756]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110598756,"title":"Optimizing Healthcare Project Management with Positive Psychology","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685707","issue":"2","volume":"1","abstract":"As healthcare organizations navigate the complexities of the industry, project managers play a central role in optimizing patient care and operational processes. In such dynamic setting, positive psychology emerges as a paradigm, offering a holistic framework that extends beyond traditional project management methodologies. Recent advancements in positive psychology research highlight its applicability across various professional domains and healthcare sector is not an exception.","page_numbers":"1-6","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"As healthcare organizations navigate the complexities of the industry, project managers play a central role in optimizing patient care and operational processes. In such dynamic setting, positive psychology emerges as a paradigm, offering a holistic framework that extends beyond traditional project management methodologies. Recent advancements in positive psychology research highlight its applicability across various professional domains and healthcare sector is not an exception.","internal_url":"https://www.academia.edu/110598756/Optimizing_Healthcare_Project_Management_with_Positive_Psychology","translated_internal_url":"","created_at":"2023-12-04T23:03:38.348-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40647630,"work_id":110598756,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":1,"name":"Shohreh Majd","title":"Optimizing Healthcare Project Management with Positive Psychology"},{"id":40647631,"work_id":110598756,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":7938022,"email":"d***d@gmx.net","display_order":2,"name":"Zohreh Majd","title":"Optimizing Healthcare Project Management with Positive Psychology"}],"downloadable_attachments":[{"id":111672546,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111672546/thumbnails/1.jpg","file_name":"1_Optimizing_Healthcare_Project_Management.pdf","download_url":"https://www.academia.edu/attachments/111672546/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Optimizing_Healthcare_Project_Management.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111672546/1_Optimizing_Healthcare_Project_Management-libre.pdf?1708484709=\u0026response-content-disposition=attachment%3B+filename%3DOptimizing_Healthcare_Project_Management.pdf\u0026Expires=1732758177\u0026Signature=AjZzjjZRqpsSqVlhfgF4DWrGSjdlkROsuKNdluBPvgGu6b0oFG-ZPYpa5bof17WkEh1rGWxoVlfoyBXvywECvlTR1qoyD6wk5AP8zXuaa2PPuYppxE417Qe0W1CqG2~PdlbyIAVRie1ibC8hm7YJGW1KeoB5l9uVPYDcTqimcaiA58o~tIuwLVqKrWA4FBJmNnvGOnziKTckPeCxcfPbgw9QvpuPOsb7DMY3cAH7FrEKGp3VCGrQ56z33l3hIsvWRNkyZ6vnPIVCABP1DcWGSB7RUYlgXy8LXTCYyawbTwsDk01lYIEmdx0YUw1IvCBfA8X9sEI6g~kUoaGJRpUL2Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Optimizing_Healthcare_Project_Management_with_Positive_Psychology","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111672546,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111672546/thumbnails/1.jpg","file_name":"1_Optimizing_Healthcare_Project_Management.pdf","download_url":"https://www.academia.edu/attachments/111672546/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Optimizing_Healthcare_Project_Management.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111672546/1_Optimizing_Healthcare_Project_Management-libre.pdf?1708484709=\u0026response-content-disposition=attachment%3B+filename%3DOptimizing_Healthcare_Project_Management.pdf\u0026Expires=1732758177\u0026Signature=AjZzjjZRqpsSqVlhfgF4DWrGSjdlkROsuKNdluBPvgGu6b0oFG-ZPYpa5bof17WkEh1rGWxoVlfoyBXvywECvlTR1qoyD6wk5AP8zXuaa2PPuYppxE417Qe0W1CqG2~PdlbyIAVRie1ibC8hm7YJGW1KeoB5l9uVPYDcTqimcaiA58o~tIuwLVqKrWA4FBJmNnvGOnziKTckPeCxcfPbgw9QvpuPOsb7DMY3cAH7FrEKGp3VCGrQ56z33l3hIsvWRNkyZ6vnPIVCABP1DcWGSB7RUYlgXy8LXTCYyawbTwsDk01lYIEmdx0YUw1IvCBfA8X9sEI6g~kUoaGJRpUL2Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":90896,"name":"Healthcare Management","url":"https://www.academia.edu/Documents/in/Healthcare_Management"}],"urls":[{"id":39651546,"url":"https://integratedrhd.com/2023-12-p1-6/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110595285"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110595285/Traumatic_Brain_Injury_and_its_Link_to_Alzheimers_Disease"><img alt="Research paper thumbnail of Traumatic Brain Injury and its Link to Alzheimer's Disease" class="work-thumbnail" src="https://attachments.academia-assets.com/111673940/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110595285/Traumatic_Brain_Injury_and_its_Link_to_Alzheimers_Disease">Traumatic Brain Injury and its Link to Alzheimer's Disease</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The intricate relationship between traumatic brain injury (TBI) and Alzheimer's disease (AD) is a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The intricate relationship between traumatic brain injury (TBI) and Alzheimer's disease (AD) is a focal point of neuroscientific inquiry. Growing evidence suggests that individuals with a history of TBI may face an elevated risk of developing memory loss later in life, including a persistent pattern connecting moderate and severe TBI with an elevated vulnerability to Alzheimer's disease and related dementias. This revelation raises significant public health concerns, prompting an in-depth exploration with a focus shift to the intricate interplay between TBI and alterations in both brain structure and function. <br />Of particular interest are the roles played by beta amyloid (Aβ) and tau protein, two molecular protagonists implicated in the trajectory from TBI to Alzheimer's pathology. Unravelling these intricacies not only elucidates the link between TBI and neurodegenerative disorders but also illuminates potential avenues for preventive interventions against Alzheimer's disease. This article contributes to a nuanced understanding of the profound consequences of TBI, offering insights that inform public health initiatives and clinical strategies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="09590ac663ae96d068ac6fe5b001f658" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111673940,"asset_id":110595285,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111673940/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110595285"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110595285"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110595285; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110595285]").text(description); $(".js-view-count[data-work-id=110595285]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110595285; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110595285']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110595285, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "09590ac663ae96d068ac6fe5b001f658" } } $('.js-work-strip[data-work-id=110595285]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110595285,"title":"Traumatic Brain Injury and its Link to Alzheimer's Disease","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685840","issue":"2","volume":"1","abstract":"The intricate relationship between traumatic brain injury (TBI) and Alzheimer's disease (AD) is a focal point of neuroscientific inquiry. Growing evidence suggests that individuals with a history of TBI may face an elevated risk of developing memory loss later in life, including a persistent pattern connecting moderate and severe TBI with an elevated vulnerability to Alzheimer's disease and related dementias. This revelation raises significant public health concerns, prompting an in-depth exploration with a focus shift to the intricate interplay between TBI and alterations in both brain structure and function. \nOf particular interest are the roles played by beta amyloid (Aβ) and tau protein, two molecular protagonists implicated in the trajectory from TBI to Alzheimer's pathology. Unravelling these intricacies not only elucidates the link between TBI and neurodegenerative disorders but also illuminates potential avenues for preventive interventions against Alzheimer's disease. This article contributes to a nuanced understanding of the profound consequences of TBI, offering insights that inform public health initiatives and clinical strategies.\n","page_numbers":"20-26","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"The intricate relationship between traumatic brain injury (TBI) and Alzheimer's disease (AD) is a focal point of neuroscientific inquiry. Growing evidence suggests that individuals with a history of TBI may face an elevated risk of developing memory loss later in life, including a persistent pattern connecting moderate and severe TBI with an elevated vulnerability to Alzheimer's disease and related dementias. This revelation raises significant public health concerns, prompting an in-depth exploration with a focus shift to the intricate interplay between TBI and alterations in both brain structure and function. \nOf particular interest are the roles played by beta amyloid (Aβ) and tau protein, two molecular protagonists implicated in the trajectory from TBI to Alzheimer's pathology. Unravelling these intricacies not only elucidates the link between TBI and neurodegenerative disorders but also illuminates potential avenues for preventive interventions against Alzheimer's disease. This article contributes to a nuanced understanding of the profound consequences of TBI, offering insights that inform public health initiatives and clinical strategies.\n","internal_url":"https://www.academia.edu/110595285/Traumatic_Brain_Injury_and_its_Link_to_Alzheimers_Disease","translated_internal_url":"","created_at":"2023-12-04T22:10:11.505-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40647400,"work_id":110595285,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":1,"name":"Shohreh Majd","title":"Traumatic Brain Injury and its Link to Alzheimer's Disease"}],"downloadable_attachments":[{"id":111673940,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111673940/thumbnails/1.jpg","file_name":"4_Traumatic_Brain_Injury_and_its_Link_to_Alzheimer_s_Disease.pdf","download_url":"https://www.academia.edu/attachments/111673940/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Traumatic_Brain_Injury_and_its_Link_to_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111673940/4_Traumatic_Brain_Injury_and_its_Link_to_Alzheimer_s_Disease-libre.pdf?1708492664=\u0026response-content-disposition=attachment%3B+filename%3DTraumatic_Brain_Injury_and_its_Link_to_A.pdf\u0026Expires=1732758177\u0026Signature=QzQv4sHXvFKh4kl7BBbCt00GNqyCmDHyZUNDo94002dLxLi7D6JNGTu7q8Ch6QfA4jADR~cz3OlXW3qdbBi5bKdWIChZMgQ4000xzE~kUzujuYVhqOhrBDgTgSy7f1aZWshklPEntbgvt4JLJDUPG9IBaQfE6Nrhgr5WIomPJ3aNWfmekYPRENo31RtQxtIKyEDc1-Zhy1xwopKZMwxGYMWYqIQKgUrwLrcIldvmUSxIX1QcyT1TTeMD-c8ItHnBdAJ0jJ6UL655uwJj~Bmsa7scD95b8ng-39ha0Ci~~qAknctT4IxxgOfbt3SH2AWjBK95RgrCCxliiTsqt0iMGg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Traumatic_Brain_Injury_and_its_Link_to_Alzheimers_Disease","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111673940,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111673940/thumbnails/1.jpg","file_name":"4_Traumatic_Brain_Injury_and_its_Link_to_Alzheimer_s_Disease.pdf","download_url":"https://www.academia.edu/attachments/111673940/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Traumatic_Brain_Injury_and_its_Link_to_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111673940/4_Traumatic_Brain_Injury_and_its_Link_to_Alzheimer_s_Disease-libre.pdf?1708492664=\u0026response-content-disposition=attachment%3B+filename%3DTraumatic_Brain_Injury_and_its_Link_to_A.pdf\u0026Expires=1732758177\u0026Signature=QzQv4sHXvFKh4kl7BBbCt00GNqyCmDHyZUNDo94002dLxLi7D6JNGTu7q8Ch6QfA4jADR~cz3OlXW3qdbBi5bKdWIChZMgQ4000xzE~kUzujuYVhqOhrBDgTgSy7f1aZWshklPEntbgvt4JLJDUPG9IBaQfE6Nrhgr5WIomPJ3aNWfmekYPRENo31RtQxtIKyEDc1-Zhy1xwopKZMwxGYMWYqIQKgUrwLrcIldvmUSxIX1QcyT1TTeMD-c8ItHnBdAJ0jJ6UL655uwJj~Bmsa7scD95b8ng-39ha0Ci~~qAknctT4IxxgOfbt3SH2AWjBK95RgrCCxliiTsqt0iMGg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3720,"name":"Traumatic Brain Injury","url":"https://www.academia.edu/Documents/in/Traumatic_Brain_Injury"},{"id":3776,"name":"Alzheimer's Disease","url":"https://www.academia.edu/Documents/in/Alzheimers_Disease"},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":162164,"name":"Beta Amyloid","url":"https://www.academia.edu/Documents/in/Beta_Amyloid"},{"id":245743,"name":"Tau Protein; Microtubules; Microtubule Dynamics","url":"https://www.academia.edu/Documents/in/Tau_Protein_Microtubules_Microtubule_Dynamics"}],"urls":[{"id":39652986,"url":"https://integratedrhd.com/2023-12-p20-26/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110592909"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110592909/Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research"><img alt="Research paper thumbnail of Tumour Microenvironment: Pivotal Players, Therapeutic Strategies, and Ongoing Frontiers in Cancer Research" class="work-thumbnail" src="https://attachments.academia-assets.com/111672904/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110592909/Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research">Tumour Microenvironment: Pivotal Players, Therapeutic Strategies, and Ongoing Frontiers in Cancer Research</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cancer progression hinges on the intricate interplay between cancer cells and the tumour microenv...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cancer progression hinges on the intricate interplay between cancer cells and the tumour microenvironment (TME), where Cancer-Associated Fibroblasts (CAFs) play a pivotal role in creating a supportive milieu. Targeting CAFs and stromal components stands as an innovative therapeutic strategy with the potential to impede tumour progression. Simultaneously, immunotherapy, particularly immune checkpoint inhibitors, revolutionizes cancer treatment by unleashing potent anti-tumour immune responses. Ongoing research into novel immune checkpoint targets and combination strategies enhances the dynamic nature of immunotherapy. Molecular signalling pathways like Transforming Growth Factor-beta (TGF-β) and Hypoxia-Inducible Factor (HIF) provide intricate insights into TME crosstalk. Dysregulation of TGF-β signalling is associated with poor prognosis, highlighting its therapeutic potential. The dynamic reciprocity between cancer cells and the Extracellular Matrix (ECM) significantly influences cancer behaviour. While substantial strides have been made, ongoing research is imperative to unravel the full complexities of the TME. This exploration serves as the foundation for personalized and targeted therapeutic strategies, combining stromal-targeted therapies, immunotherapy advancements, and insights into molecular signalling pathways. This review navigates the multifaceted ways the TME influences cancer progression, offering a comprehensive understanding that propels innovative therapeutic interventions. Ultimately, this signifies the relentless pursuit of effective cancer treatments, fostering hope and a promising era in the fight against cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9614d2c4afeafaaf406ba2b2af2e9053" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111672904,"asset_id":110592909,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111672904/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110592909"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110592909"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110592909; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110592909]").text(description); $(".js-view-count[data-work-id=110592909]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110592909; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110592909']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110592909, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9614d2c4afeafaaf406ba2b2af2e9053" } } $('.js-work-strip[data-work-id=110592909]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110592909,"title":"Tumour Microenvironment: Pivotal Players, Therapeutic Strategies, and Ongoing Frontiers in Cancer Research","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685757","abstract":"Cancer progression hinges on the intricate interplay between cancer cells and the tumour microenvironment (TME), where Cancer-Associated Fibroblasts (CAFs) play a pivotal role in creating a supportive milieu. Targeting CAFs and stromal components stands as an innovative therapeutic strategy with the potential to impede tumour progression. Simultaneously, immunotherapy, particularly immune checkpoint inhibitors, revolutionizes cancer treatment by unleashing potent anti-tumour immune responses. Ongoing research into novel immune checkpoint targets and combination strategies enhances the dynamic nature of immunotherapy. Molecular signalling pathways like Transforming Growth Factor-beta (TGF-β) and Hypoxia-Inducible Factor (HIF) provide intricate insights into TME crosstalk. Dysregulation of TGF-β signalling is associated with poor prognosis, highlighting its therapeutic potential. The dynamic reciprocity between cancer cells and the Extracellular Matrix (ECM) significantly influences cancer behaviour. While substantial strides have been made, ongoing research is imperative to unravel the full complexities of the TME. This exploration serves as the foundation for personalized and targeted therapeutic strategies, combining stromal-targeted therapies, immunotherapy advancements, and insights into molecular signalling pathways. This review navigates the multifaceted ways the TME influences cancer progression, offering a comprehensive understanding that propels innovative therapeutic interventions. Ultimately, this signifies the relentless pursuit of effective cancer treatments, fostering hope and a promising era in the fight against cancer.","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"Cancer progression hinges on the intricate interplay between cancer cells and the tumour microenvironment (TME), where Cancer-Associated Fibroblasts (CAFs) play a pivotal role in creating a supportive milieu. Targeting CAFs and stromal components stands as an innovative therapeutic strategy with the potential to impede tumour progression. Simultaneously, immunotherapy, particularly immune checkpoint inhibitors, revolutionizes cancer treatment by unleashing potent anti-tumour immune responses. Ongoing research into novel immune checkpoint targets and combination strategies enhances the dynamic nature of immunotherapy. Molecular signalling pathways like Transforming Growth Factor-beta (TGF-β) and Hypoxia-Inducible Factor (HIF) provide intricate insights into TME crosstalk. Dysregulation of TGF-β signalling is associated with poor prognosis, highlighting its therapeutic potential. The dynamic reciprocity between cancer cells and the Extracellular Matrix (ECM) significantly influences cancer behaviour. While substantial strides have been made, ongoing research is imperative to unravel the full complexities of the TME. This exploration serves as the foundation for personalized and targeted therapeutic strategies, combining stromal-targeted therapies, immunotherapy advancements, and insights into molecular signalling pathways. This review navigates the multifaceted ways the TME influences cancer progression, offering a comprehensive understanding that propels innovative therapeutic interventions. Ultimately, this signifies the relentless pursuit of effective cancer treatments, fostering hope and a promising era in the fight against cancer.","internal_url":"https://www.academia.edu/110592909/Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research","translated_internal_url":"","created_at":"2023-12-04T21:27:54.410-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40647035,"work_id":110592909,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":1,"name":"Shohreh Majd","title":"Tumour Microenvironment: Pivotal Players, Therapeutic Strategies, and Ongoing Frontiers in Cancer Research"},{"id":40647036,"work_id":110592909,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":7976542,"email":"r***z@proton.me","display_order":5,"name":"Perez M","title":"Tumour Microenvironment: Pivotal Players, Therapeutic Strategies, and Ongoing Frontiers in Cancer Research"}],"downloadable_attachments":[{"id":111672904,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111672904/thumbnails/1.jpg","file_name":"3_Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research.pdf","download_url":"https://www.academia.edu/attachments/111672904/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tumour_Microenvironment_Pivotal_Players.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111672904/3_Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research-libre.pdf?1708510441=\u0026response-content-disposition=attachment%3B+filename%3DTumour_Microenvironment_Pivotal_Players.pdf\u0026Expires=1732758177\u0026Signature=VWsJaHKaErLhpRL0WoYUi8LoakGLQ-mjMrAW2BSw8MS-BX3nwRPlTqQT0YUfW6ZIE6aVrkZXvJ3XGfvFH5wWgAFog6tH4BLdPxqhxpU0d9pdbKGMaFLBhSEJeEGugQyUbMiH-cJU50OREvLkkKFj1gtYz6aH9NA4w9tTATkI7Y3IRGAEtnsI~IXPkF5-ryrb3j1ubAX-NtvvPDvul0WF-B8lKgFvNtcPXwqeFz5BHimDMf8gG-EQskKHlN~EuWfguBm-aYEaMS~8pGWw30SyYIh8J5r1wYiMZt7yw1gr-03uEHkwxG7QqcDAR~JHaDstzMtcyfBv9lcPs1KQC9LH5Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111672904,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111672904/thumbnails/1.jpg","file_name":"3_Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research.pdf","download_url":"https://www.academia.edu/attachments/111672904/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tumour_Microenvironment_Pivotal_Players.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111672904/3_Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research-libre.pdf?1708510441=\u0026response-content-disposition=attachment%3B+filename%3DTumour_Microenvironment_Pivotal_Players.pdf\u0026Expires=1732758177\u0026Signature=VWsJaHKaErLhpRL0WoYUi8LoakGLQ-mjMrAW2BSw8MS-BX3nwRPlTqQT0YUfW6ZIE6aVrkZXvJ3XGfvFH5wWgAFog6tH4BLdPxqhxpU0d9pdbKGMaFLBhSEJeEGugQyUbMiH-cJU50OREvLkkKFj1gtYz6aH9NA4w9tTATkI7Y3IRGAEtnsI~IXPkF5-ryrb3j1ubAX-NtvvPDvul0WF-B8lKgFvNtcPXwqeFz5BHimDMf8gG-EQskKHlN~EuWfguBm-aYEaMS~8pGWw30SyYIh8J5r1wYiMZt7yw1gr-03uEHkwxG7QqcDAR~JHaDstzMtcyfBv9lcPs1KQC9LH5Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":14195,"name":"Cancer Biology","url":"https://www.academia.edu/Documents/in/Cancer_Biology"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":78754,"name":"Cancer Therapy","url":"https://www.academia.edu/Documents/in/Cancer_Therapy"},{"id":256053,"name":"Tumour microenvironment","url":"https://www.academia.edu/Documents/in/Tumour_microenvironment"},{"id":1961441,"name":"Signalling Pathways","url":"https://www.academia.edu/Documents/in/Signalling_Pathways"}],"urls":[{"id":36463736,"url":"https://integratedrhd.com/2023-12-p13-19/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110497045"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110497045/Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage"><img alt="Research paper thumbnail of Advances in Understanding and Managing Postpartum Hemorrhage" class="work-thumbnail" src="https://attachments.academia-assets.com/111672707/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110497045/Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage">Advances in Understanding and Managing Postpartum Hemorrhage</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Postpartum hemorrhage (PPH), characterized by excessive bleeding within 24 hours of childbirth, p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Postpartum hemorrhage (PPH), characterized by excessive bleeding within 24 hours of childbirth, poses a significant global challenge in maternal healthcare, contributing substantially to mortality and morbidity, especially in low-income countries. The timely recognition of clinical manifestations, such as persistent bleeding and organ dysfunction are critical for effective intervention. This requires a comprehensive approach and management strategies such as pharmacological, surgical, and interventional techniques. Here we explore the multifactorial etiology of PPH, including uterine atony, genital tract trauma, retained placental tissue, and coagulopathies and examine the latest findings in the area of PPH management towards reducing mortality and morbidity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eb75a8bdf43946b56332b5a27c548f15" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111672707,"asset_id":110497045,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111672707/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110497045"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110497045"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110497045; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110497045]").text(description); $(".js-view-count[data-work-id=110497045]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110497045; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110497045']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110497045, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "eb75a8bdf43946b56332b5a27c548f15" } } $('.js-work-strip[data-work-id=110497045]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110497045,"title":"Advances in Understanding and Managing Postpartum Hemorrhage","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685736","issue":"2","volume":"1","abstract":"Postpartum hemorrhage (PPH), characterized by excessive bleeding within 24 hours of childbirth, poses a significant global challenge in maternal healthcare, contributing substantially to mortality and morbidity, especially in low-income countries. The timely recognition of clinical manifestations, such as persistent bleeding and organ dysfunction are critical for effective intervention. This requires a comprehensive approach and management strategies such as pharmacological, surgical, and interventional techniques. Here we explore the multifactorial etiology of PPH, including uterine atony, genital tract trauma, retained placental tissue, and coagulopathies and examine the latest findings in the area of PPH management towards reducing mortality and morbidity.","page_numbers":"7-12","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"Postpartum hemorrhage (PPH), characterized by excessive bleeding within 24 hours of childbirth, poses a significant global challenge in maternal healthcare, contributing substantially to mortality and morbidity, especially in low-income countries. The timely recognition of clinical manifestations, such as persistent bleeding and organ dysfunction are critical for effective intervention. This requires a comprehensive approach and management strategies such as pharmacological, surgical, and interventional techniques. Here we explore the multifactorial etiology of PPH, including uterine atony, genital tract trauma, retained placental tissue, and coagulopathies and examine the latest findings in the area of PPH management towards reducing mortality and morbidity.","internal_url":"https://www.academia.edu/110497045/Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage","translated_internal_url":"","created_at":"2023-12-03T22:07:00.474-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40638704,"work_id":110497045,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":7974923,"email":"i***z@aol.com","display_order":4,"name":"Isabella Alvarez","title":"Advances in Understanding and Managing Postpartum Hemorrhage"}],"downloadable_attachments":[{"id":111672707,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111672707/thumbnails/1.jpg","file_name":"2_Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage_.pdf","download_url":"https://www.academia.edu/attachments/111672707/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Advances_in_Understanding_and_Managing_P.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111672707/2_Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage_-libre.pdf?1708514403=\u0026response-content-disposition=attachment%3B+filename%3DAdvances_in_Understanding_and_Managing_P.pdf\u0026Expires=1732758177\u0026Signature=K1nwgQ05AeCnUNQvLy-S0~IPRPyeRscB-AUOfpA~Pnvc7c4fi51p-UAIhrutB7QHyQLBTig8fWsYp06fPczBbJqsQZobc61xeKr7ztrAZxgGyE6nW-9~KUODQHO0YEQ7SQEjafPCOn8IpjS4ZWHdCiv2GgmuKYf8DibXcO87GMbDfygZbHypEVD1THHHyJ87xbcRkA28zWFhxL4ig92IH2Q1Wkc9x2cwAkmoXu1bBHYbAZFVwk2ZgNTK2cbYmpYIxO893dqv-wDstv2D82RKTIaLaW98N~QhWSyfQJmpDJiq3uWMSLMAB169vD~6p5OGod4WL04--jUYtSelFj8i9Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111672707,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111672707/thumbnails/1.jpg","file_name":"2_Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage_.pdf","download_url":"https://www.academia.edu/attachments/111672707/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Advances_in_Understanding_and_Managing_P.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111672707/2_Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage_-libre.pdf?1708514403=\u0026response-content-disposition=attachment%3B+filename%3DAdvances_in_Understanding_and_Managing_P.pdf\u0026Expires=1732758177\u0026Signature=K1nwgQ05AeCnUNQvLy-S0~IPRPyeRscB-AUOfpA~Pnvc7c4fi51p-UAIhrutB7QHyQLBTig8fWsYp06fPczBbJqsQZobc61xeKr7ztrAZxgGyE6nW-9~KUODQHO0YEQ7SQEjafPCOn8IpjS4ZWHdCiv2GgmuKYf8DibXcO87GMbDfygZbHypEVD1THHHyJ87xbcRkA28zWFhxL4ig92IH2Q1Wkc9x2cwAkmoXu1bBHYbAZFVwk2ZgNTK2cbYmpYIxO893dqv-wDstv2D82RKTIaLaW98N~QhWSyfQJmpDJiq3uWMSLMAB169vD~6p5OGod4WL04--jUYtSelFj8i9Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":163604,"name":"Nursing and midwifery","url":"https://www.academia.edu/Documents/in/Nursing_and_midwifery"}],"urls":[{"id":39651702,"url":"https://integratedrhd.com/2023-12-p1-7-12/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110442257"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110442257/Beta_estradiol_and_norepinephrine_treatment_of_differentiated_SH_SY5Y_cells_enhances_tau_phosphorylation_at_Ser396_and_Ser262_via_AMPK_but_not_mTOR_signaling_pathway"><img alt="Research paper thumbnail of Beta estradiol and norepinephrine treatment of differentiated SH-SY5Y cells enhances tau phosphorylation at (Ser396) and (Ser262) via AMPK but not mTOR signaling pathway" class="work-thumbnail" src="https://attachments.academia-assets.com/108258639/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110442257/Beta_estradiol_and_norepinephrine_treatment_of_differentiated_SH_SY5Y_cells_enhances_tau_phosphorylation_at_Ser396_and_Ser262_via_AMPK_but_not_mTOR_signaling_pathway">Beta estradiol and norepinephrine treatment of differentiated SH-SY5Y cells enhances tau phosphorylation at (Ser396) and (Ser262) via AMPK but not mTOR signaling pathway</a></div><div class="wp-workCard_item"><span>Molecular and Cellular Neuroscience</span><span>, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e8a47e00eb86efd9839df7f735e895ee" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108258639,"asset_id":110442257,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108258639/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110442257"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110442257"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110442257; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110442257]").text(description); $(".js-view-count[data-work-id=110442257]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110442257; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110442257']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110442257, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e8a47e00eb86efd9839df7f735e895ee" } } $('.js-work-strip[data-work-id=110442257]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110442257,"title":"Beta estradiol and norepinephrine treatment of differentiated SH-SY5Y cells enhances tau phosphorylation at (Ser396) and (Ser262) via AMPK but not mTOR signaling pathway","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Beta estradiol and norepinephrine treatment of differentiated SH-SY5Y cells enhances tau phosphorylation at (Ser396) and (Ser262) via AMPK but not mTOR signaling pathway.","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Molecular and Cellular Neuroscience","grobid_abstract_attachment_id":108258639},"translated_abstract":null,"internal_url":"https://www.academia.edu/110442257/Beta_estradiol_and_norepinephrine_treatment_of_differentiated_SH_SY5Y_cells_enhances_tau_phosphorylation_at_Ser396_and_Ser262_via_AMPK_but_not_mTOR_signaling_pathway","translated_internal_url":"","created_at":"2023-12-03T05:55:28.089-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":108258639,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108258639/thumbnails/1.jpg","file_name":"Majd_Beta_AM2018.pdf","download_url":"https://www.academia.edu/attachments/108258639/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Beta_estradiol_and_norepinephrine_treatm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108258639/Majd_Beta_AM2018-libre.pdf?1701614612=\u0026response-content-disposition=attachment%3B+filename%3DBeta_estradiol_and_norepinephrine_treatm.pdf\u0026Expires=1732758177\u0026Signature=DqAsfxtdRgM8kcyBsCHnyuvUvg5VotNduHwKUgj5nQtVN42xbH0pnPrXJz9LKDfgkgD0GtUgtNYmfD9tfoBO4vxFn3hx6V6xsbSWWMx6sHzbyXq5c9HOVpATuTs7tCNp827toOrxhgBxfA76UyWFBKdorj7dIq~PL7B~A~EwISEzJUz81GuG5WzCbDcCmAcyamWlD4sik3wH-GugL8MPGT0c--m~TZqjEXZKMCSClBPU4XwndUGLBHZBJEWRtIOZ5N1SqGfEgkQ8T3rKOjTW7ukbCWWLUmutYCgzySGkqHLlrR54QjaVURDrJFCI76EFLXYYegrWjMmESE2U2zVHkg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Beta_estradiol_and_norepinephrine_treatment_of_differentiated_SH_SY5Y_cells_enhances_tau_phosphorylation_at_Ser396_and_Ser262_via_AMPK_but_not_mTOR_signaling_pathway","translated_slug":"","page_count":33,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":108258639,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108258639/thumbnails/1.jpg","file_name":"Majd_Beta_AM2018.pdf","download_url":"https://www.academia.edu/attachments/108258639/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Beta_estradiol_and_norepinephrine_treatm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108258639/Majd_Beta_AM2018-libre.pdf?1701614612=\u0026response-content-disposition=attachment%3B+filename%3DBeta_estradiol_and_norepinephrine_treatm.pdf\u0026Expires=1732758177\u0026Signature=DqAsfxtdRgM8kcyBsCHnyuvUvg5VotNduHwKUgj5nQtVN42xbH0pnPrXJz9LKDfgkgD0GtUgtNYmfD9tfoBO4vxFn3hx6V6xsbSWWMx6sHzbyXq5c9HOVpATuTs7tCNp827toOrxhgBxfA76UyWFBKdorj7dIq~PL7B~A~EwISEzJUz81GuG5WzCbDcCmAcyamWlD4sik3wH-GugL8MPGT0c--m~TZqjEXZKMCSClBPU4XwndUGLBHZBJEWRtIOZ5N1SqGfEgkQ8T3rKOjTW7ukbCWWLUmutYCgzySGkqHLlrR54QjaVURDrJFCI76EFLXYYegrWjMmESE2U2zVHkg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":172084,"name":"AMPK","url":"https://www.academia.edu/Documents/in/AMPK"},{"id":223869,"name":"Protein Phosphatase 2A","url":"https://www.academia.edu/Documents/in/Protein_Phosphatase_2A"},{"id":235189,"name":"Norepinephrine","url":"https://www.academia.edu/Documents/in/Norepinephrine"},{"id":364836,"name":"Rapamycin","url":"https://www.academia.edu/Documents/in/Rapamycin"},{"id":594811,"name":"Cellular and Molecular Neuroscience","url":"https://www.academia.edu/Documents/in/Cellular_and_Molecular_Neuroscience"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":36347158,"url":"https://api.elsevier.com/content/article/PII:S1044743117302397?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="18508617" id="papers"><div class="js-work-strip profile--work_container" data-work-id="121978069"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121978069/Dysregulation_of_Neuronal_Iron_Homeostasis_as_an_Alternative_Unifying_Effect_of_Mutations_Causing_Familial_Alzheimers_Disease"><img alt="Research paper thumbnail of Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease" class="work-thumbnail" src="https://attachments.academia-assets.com/116734018/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121978069/Dysregulation_of_Neuronal_Iron_Homeostasis_as_an_Alternative_Unifying_Effect_of_Mutations_Causing_Familial_Alzheimers_Disease">Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease</a></div><div class="wp-workCard_item"><span>Frontiers in neuroscience</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The overwhelming majority of dominant mutations causing early onset familial Alzheimer&#39;s dise...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The overwhelming majority of dominant mutations causing early onset familial Alzheimer&#39;s disease (EOfAD) occur in only three genes, , and . An effect-in-common of these mutations is alteration of production of the APP-derived peptide, amyloid β (Aβ). It is this key fact that underlies the authority of the Amyloid Hypothesis that has informed Alzheimer&#39;s disease research for over two decades. Any challenge to this authority must offer an alternative explanation for the relationship between the genes and . In this paper, we explore one possible alternative relationship - the dysregulation of cellular iron homeostasis as a common effect of EOfAD mutations in these genes. This idea is attractive since it provides clear connections between EOfAD mutations and major characteristics of Alzheimer&#39;s disease such as dysfunctional mitochondria, vascular risk factors/hypoxia, energy metabolism, and inflammation. We combine our ideas with observations by others to describe a &quot;St...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7edc46e08096cd49c7519dcc7503f977" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116734018,"asset_id":121978069,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116734018/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121978069"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121978069"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121978069; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121978069]").text(description); $(".js-view-count[data-work-id=121978069]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121978069; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121978069']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 121978069, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7edc46e08096cd49c7519dcc7503f977" } } $('.js-work-strip[data-work-id=121978069]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121978069,"title":"Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease","translated_title":"","metadata":{"abstract":"The overwhelming majority of dominant mutations causing early onset familial Alzheimer\u0026#39;s disease (EOfAD) occur in only three genes, , and . An effect-in-common of these mutations is alteration of production of the APP-derived peptide, amyloid β (Aβ). It is this key fact that underlies the authority of the Amyloid Hypothesis that has informed Alzheimer\u0026#39;s disease research for over two decades. Any challenge to this authority must offer an alternative explanation for the relationship between the genes and . In this paper, we explore one possible alternative relationship - the dysregulation of cellular iron homeostasis as a common effect of EOfAD mutations in these genes. This idea is attractive since it provides clear connections between EOfAD mutations and major characteristics of Alzheimer\u0026#39;s disease such as dysfunctional mitochondria, vascular risk factors/hypoxia, energy metabolism, and inflammation. We combine our ideas with observations by others to describe a \u0026quot;St...","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Frontiers in neuroscience"},"translated_abstract":"The overwhelming majority of dominant mutations causing early onset familial Alzheimer\u0026#39;s disease (EOfAD) occur in only three genes, , and . An effect-in-common of these mutations is alteration of production of the APP-derived peptide, amyloid β (Aβ). It is this key fact that underlies the authority of the Amyloid Hypothesis that has informed Alzheimer\u0026#39;s disease research for over two decades. Any challenge to this authority must offer an alternative explanation for the relationship between the genes and . In this paper, we explore one possible alternative relationship - the dysregulation of cellular iron homeostasis as a common effect of EOfAD mutations in these genes. This idea is attractive since it provides clear connections between EOfAD mutations and major characteristics of Alzheimer\u0026#39;s disease such as dysfunctional mitochondria, vascular risk factors/hypoxia, energy metabolism, and inflammation. We combine our ideas with observations by others to describe a \u0026quot;St...","internal_url":"https://www.academia.edu/121978069/Dysregulation_of_Neuronal_Iron_Homeostasis_as_an_Alternative_Unifying_Effect_of_Mutations_Causing_Familial_Alzheimers_Disease","translated_internal_url":"","created_at":"2024-07-11T22:14:50.524-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":116734018,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116734018/thumbnails/1.jpg","file_name":"271405.pdf","download_url":"https://www.academia.edu/attachments/116734018/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dysregulation_of_Neuronal_Iron_Homeostas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116734018/271405-libre.pdf?1720765573=\u0026response-content-disposition=attachment%3B+filename%3DDysregulation_of_Neuronal_Iron_Homeostas.pdf\u0026Expires=1732758176\u0026Signature=Ip8wu3ncveomHHaPzjYPyj5fMII-m-Opcs2Dvn1DH6eMoG8dVGIsp3YnWNCUDI5sL1gJeeldXLZtduxVsxupUuw2MBkA-jKSCZ-6be06YeCNEkNdx~4b81C~9qJrTi2M4nRIwCfABNnstD1efk9E9q-Lf3RGO1-ifyTxtC~W-1jvCKeou~ZXlnzJ5kPa9jPnV~nGLycp75zhzqBMBxPGXHNaxmehbrkVYz5ZnlsAVViKAKSSHEQPEEkNkJLnqlV1K6IWViOInw-hgmPPBvKEVkLtxNfFk1rFpwL2mNIB~EbUWxnlU~Qve3vfpfIHtGKyaNxUDnLdK9UPCOj7yY3TRQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Dysregulation_of_Neuronal_Iron_Homeostasis_as_an_Alternative_Unifying_Effect_of_Mutations_Causing_Familial_Alzheimers_Disease","translated_slug":"","page_count":21,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":116734018,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116734018/thumbnails/1.jpg","file_name":"271405.pdf","download_url":"https://www.academia.edu/attachments/116734018/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Dysregulation_of_Neuronal_Iron_Homeostas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116734018/271405-libre.pdf?1720765573=\u0026response-content-disposition=attachment%3B+filename%3DDysregulation_of_Neuronal_Iron_Homeostas.pdf\u0026Expires=1732758176\u0026Signature=Ip8wu3ncveomHHaPzjYPyj5fMII-m-Opcs2Dvn1DH6eMoG8dVGIsp3YnWNCUDI5sL1gJeeldXLZtduxVsxupUuw2MBkA-jKSCZ-6be06YeCNEkNdx~4b81C~9qJrTi2M4nRIwCfABNnstD1efk9E9q-Lf3RGO1-ifyTxtC~W-1jvCKeou~ZXlnzJ5kPa9jPnV~nGLycp75zhzqBMBxPGXHNaxmehbrkVYz5ZnlsAVViKAKSSHEQPEEkNkJLnqlV1K6IWViOInw-hgmPPBvKEVkLtxNfFk1rFpwL2mNIB~EbUWxnlU~Qve3vfpfIHtGKyaNxUDnLdK9UPCOj7yY3TRQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience"},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":99773,"name":"Disease","url":"https://www.academia.edu/Documents/in/Disease"},{"id":452440,"name":"Presenilin-2","url":"https://www.academia.edu/Documents/in/Presenilin-2"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="120126583"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120126583/Early_Glycogen_Synthase_Kinase_3%CE%B2_GSK_3%CE%B2_and_Protein_Phosphatase_2A_PP2A_independent_tau_dephosphorylation_during_global_brain_ischemia_and_reperfusion_following_cardiac_arrest_and_the_role_of_the_Adenosine_Monophosphate_Kinase_AMPK_pathway"><img alt="Research paper thumbnail of Early Glycogen Synthase Kinase-3β (GSK-3β) and Protein Phosphatase 2A (PP2A) independent tau dephosphorylation during global brain ischemia and reperfusion following cardiac arrest and the role of the Adenosine Monophosphate Kinase (AMPK) pathway" class="work-thumbnail" src="https://attachments.academia-assets.com/115377719/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120126583/Early_Glycogen_Synthase_Kinase_3%CE%B2_GSK_3%CE%B2_and_Protein_Phosphatase_2A_PP2A_independent_tau_dephosphorylation_during_global_brain_ischemia_and_reperfusion_following_cardiac_arrest_and_the_role_of_the_Adenosine_Monophosphate_Kinase_AMPK_pathway">Early Glycogen Synthase Kinase-3β (GSK-3β) and Protein Phosphatase 2A (PP2A) independent tau dephosphorylation during global brain ischemia and reperfusion following cardiac arrest and the role of the Adenosine Monophosphate Kinase (AMPK) pathway</a></div><div class="wp-workCard_item"><span>The European journal of neuroscience</span><span>, Jan 14, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abnormal tau phosphorylation (p-tau) has been shown after hypoxic damage to the brain associated ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abnormal tau phosphorylation (p-tau) has been shown after hypoxic damage to the brain associated with traumatic brain injury and stroke. As the level of p-tau is controlled by Glycogen Synthase Kinase (GSK)-3β, Protein Phosphatase 2A (PP2A) and Adenosine Monophosphate Kinase (AMPK), different activity levels of these enzymes could be involved in tau phosphorylation following ischemia. This study assessed the effects of global brain ischemia/reperfusion on the immediate status of p-tau in a rat model of cardiac arrest (CA) followed by cardiopulmonary resuscitation (CPR). We reported an early dephosphorylation of tau at its AMPK sensitive residues, Ser(396) and Ser(262) after 2 min of ischemia, which did not recover during up to two hours of reperfusion, while the tau phosphorylation at GSK-3β sensitive but AMPK insensitive residues, Ser(202) /Thr(205) (AT8), as well as the total amount of tau remained unchanged. Our data showed no alteration in the activities of GSK-3β and PP2A durin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f4d57eeda026c470d7d0980f81f640df" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115377719,"asset_id":120126583,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115377719/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120126583"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120126583"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120126583; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120126583]").text(description); $(".js-view-count[data-work-id=120126583]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120126583; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120126583']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 120126583, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f4d57eeda026c470d7d0980f81f640df" } } $('.js-work-strip[data-work-id=120126583]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120126583,"title":"Early Glycogen Synthase Kinase-3β (GSK-3β) and Protein Phosphatase 2A (PP2A) independent tau dephosphorylation during global brain ischemia and reperfusion following cardiac arrest and the role of the Adenosine Monophosphate Kinase (AMPK) pathway","translated_title":"","metadata":{"abstract":"Abnormal tau phosphorylation (p-tau) has been shown after hypoxic damage to the brain associated with traumatic brain injury and stroke. As the level of p-tau is controlled by Glycogen Synthase Kinase (GSK)-3β, Protein Phosphatase 2A (PP2A) and Adenosine Monophosphate Kinase (AMPK), different activity levels of these enzymes could be involved in tau phosphorylation following ischemia. This study assessed the effects of global brain ischemia/reperfusion on the immediate status of p-tau in a rat model of cardiac arrest (CA) followed by cardiopulmonary resuscitation (CPR). We reported an early dephosphorylation of tau at its AMPK sensitive residues, Ser(396) and Ser(262) after 2 min of ischemia, which did not recover during up to two hours of reperfusion, while the tau phosphorylation at GSK-3β sensitive but AMPK insensitive residues, Ser(202) /Thr(205) (AT8), as well as the total amount of tau remained unchanged. Our data showed no alteration in the activities of GSK-3β and PP2A durin...","publication_date":{"day":14,"month":1,"year":2016,"errors":{}},"publication_name":"The European journal of neuroscience"},"translated_abstract":"Abnormal tau phosphorylation (p-tau) has been shown after hypoxic damage to the brain associated with traumatic brain injury and stroke. As the level of p-tau is controlled by Glycogen Synthase Kinase (GSK)-3β, Protein Phosphatase 2A (PP2A) and Adenosine Monophosphate Kinase (AMPK), different activity levels of these enzymes could be involved in tau phosphorylation following ischemia. This study assessed the effects of global brain ischemia/reperfusion on the immediate status of p-tau in a rat model of cardiac arrest (CA) followed by cardiopulmonary resuscitation (CPR). We reported an early dephosphorylation of tau at its AMPK sensitive residues, Ser(396) and Ser(262) after 2 min of ischemia, which did not recover during up to two hours of reperfusion, while the tau phosphorylation at GSK-3β sensitive but AMPK insensitive residues, Ser(202) /Thr(205) (AT8), as well as the total amount of tau remained unchanged. Our data showed no alteration in the activities of GSK-3β and PP2A durin...","internal_url":"https://www.academia.edu/120126583/Early_Glycogen_Synthase_Kinase_3%CE%B2_GSK_3%CE%B2_and_Protein_Phosphatase_2A_PP2A_independent_tau_dephosphorylation_during_global_brain_ischemia_and_reperfusion_following_cardiac_arrest_and_the_role_of_the_Adenosine_Monophosphate_Kinase_AMPK_pathway","translated_internal_url":"","created_at":"2024-05-27T16:53:23.687-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115377719,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115377719/thumbnails/1.jpg","file_name":"pmc5089632.pdf","download_url":"https://www.academia.edu/attachments/115377719/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Early_Glycogen_Synthase_Kinase_3_GSK_3.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115377719/pmc5089632-libre.pdf?1716856565=\u0026response-content-disposition=attachment%3B+filename%3DEarly_Glycogen_Synthase_Kinase_3_GSK_3.pdf\u0026Expires=1732758176\u0026Signature=D9Fo2FPYV8-J1qjtboJOekGVhpUuDunFfFXm78~1VlHZ6AfpK9h4rhuM~5tRECSIe3r3DcnWN-YnbbMU0mmmY7xSP6BEbKQcDXD9b94A4ii3lK1rkq9cAdQimVrj420qDrLRkWm936RtzBXn~7TdiuZypmouItJHT-PZAfx7aH4limzmCB2~YQ7JSV1RWjJbnEiXxu~HUkf7oB8hVA7hWTOb80FMcg6H-P2VIagAaS8yRsAzgzb8Wo00SlqLRPTE2lGY83codRHTqo7DT7RRkDXvPvgYKsnKqg7wJfUSFW96gGb3lO1xi0sZNhXrFrb~LUPQtD~cwsEZ6dnDRtIunw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Early_Glycogen_Synthase_Kinase_3β_GSK_3β_and_Protein_Phosphatase_2A_PP2A_independent_tau_dephosphorylation_during_global_brain_ischemia_and_reperfusion_following_cardiac_arrest_and_the_role_of_the_Adenosine_Monophosphate_Kinase_AMPK_pathway","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":115377719,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115377719/thumbnails/1.jpg","file_name":"pmc5089632.pdf","download_url":"https://www.academia.edu/attachments/115377719/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Early_Glycogen_Synthase_Kinase_3_GSK_3.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115377719/pmc5089632-libre.pdf?1716856565=\u0026response-content-disposition=attachment%3B+filename%3DEarly_Glycogen_Synthase_Kinase_3_GSK_3.pdf\u0026Expires=1732758176\u0026Signature=D9Fo2FPYV8-J1qjtboJOekGVhpUuDunFfFXm78~1VlHZ6AfpK9h4rhuM~5tRECSIe3r3DcnWN-YnbbMU0mmmY7xSP6BEbKQcDXD9b94A4ii3lK1rkq9cAdQimVrj420qDrLRkWm936RtzBXn~7TdiuZypmouItJHT-PZAfx7aH4limzmCB2~YQ7JSV1RWjJbnEiXxu~HUkf7oB8hVA7hWTOb80FMcg6H-P2VIagAaS8yRsAzgzb8Wo00SlqLRPTE2lGY83codRHTqo7DT7RRkDXvPvgYKsnKqg7wJfUSFW96gGb3lO1xi0sZNhXrFrb~LUPQtD~cwsEZ6dnDRtIunw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":172083,"name":"Phosphorylation","url":"https://www.academia.edu/Documents/in/Phosphorylation"},{"id":172084,"name":"AMPK","url":"https://www.academia.edu/Documents/in/AMPK"},{"id":223869,"name":"Protein Phosphatase 2A","url":"https://www.academia.edu/Documents/in/Protein_Phosphatase_2A"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1818690,"name":"Adenosine monophosphate","url":"https://www.academia.edu/Documents/in/Adenosine_monophosphate"},{"id":1953129,"name":"Dephosphorylation","url":"https://www.academia.edu/Documents/in/Dephosphorylation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="118605431"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/118605431/Access_to_Ambulance_Services_for_People_with_Dementia_A_Comprehensive_Review_of_Facts_Challenges_Strategies_and_Future_Scopes"><img alt="Research paper thumbnail of Access to Ambulance Services for People with Dementia: A Comprehensive Review of Facts, Challenges, Strategies and Future Scopes" class="work-thumbnail" src="https://attachments.academia-assets.com/114191115/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/118605431/Access_to_Ambulance_Services_for_People_with_Dementia_A_Comprehensive_Review_of_Facts_Challenges_Strategies_and_Future_Scopes">Access to Ambulance Services for People with Dementia: A Comprehensive Review of Facts, Challenges, Strategies and Future Scopes</a></div><div class="wp-workCard_item"><span>International Journal of Research Publication and Reviews</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3701d267359e19325e88701ed19297a5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":114191115,"asset_id":118605431,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/114191115/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="118605431"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="118605431"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 118605431; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=118605431]").text(description); $(".js-view-count[data-work-id=118605431]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 118605431; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='118605431']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 118605431, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3701d267359e19325e88701ed19297a5" } } $('.js-work-strip[data-work-id=118605431]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":118605431,"title":"Access to Ambulance Services for People with Dementia: A Comprehensive Review of Facts, Challenges, Strategies and Future Scopes","translated_title":"","metadata":{"publisher":"Genesis Global Publication","grobid_abstract":"Dementia is a progressive neurological impairment, causing a significant public health challenge worldwide. This pathological condition is characterized by cognitive decline and impairment in memory, thinking, behaviour, and the ability to perform daily activities. In Australia, dementia is a major health issue, with over 472,000 cases as of 2022. As the population ages, it is expected for this number to increase to 1.1 million by 2058, if no effective interventions are found. The impact of dementia on individuals, families, caregivers, and society in general, leads to an increase in demand for healthcare and emergency services. Currently, there is limited research on challenges that are faced by individuals with dementia in navigating the healthcare system for a timely and proper access to emergency care such as ambulance services. This review article will provide a comprehensive overview of the current state of research on the access of patients with dementia to ambulance services and the impact of dementia on ambulance utilization. This article also identifies the opportunities and directions for future research and interventions to improve the care and outcomes for individuals with dementia in the prehospital setting.","publication_name":"International Journal of Research Publication and Reviews","grobid_abstract_attachment_id":114191115},"translated_abstract":null,"internal_url":"https://www.academia.edu/118605431/Access_to_Ambulance_Services_for_People_with_Dementia_A_Comprehensive_Review_of_Facts_Challenges_Strategies_and_Future_Scopes","translated_internal_url":"","created_at":"2024-05-05T20:33:31.691-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":114191115,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/114191115/thumbnails/1.jpg","file_name":"gengpi.4.623.pdf","download_url":"https://www.academia.edu/attachments/114191115/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Access_to_Ambulance_Services_for_People.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/114191115/gengpi.4.623-libre.pdf?1714967168=\u0026response-content-disposition=attachment%3B+filename%3DAccess_to_Ambulance_Services_for_People.pdf\u0026Expires=1732758176\u0026Signature=Tfs~UlUmOhTOmiaHRu-SYSon8ieb-8XX6Jkh4q4BnY9iI~b-JFyZJ0frS5nW-6LW2G-czA-~gHFLo~O6j6kaGhzl-PgcKkf2dF-qnZ9TeyyOfjCKlz-LdkDzkmJVjB92U8-0poTH~NwTCIHV0Zpfb3Gg3FE2XCsR~v1l3ezY214mVXh9CbQLvazX8gRmQrqCnyDHFwehqojJWwYFE846jpVAYOunmT8zdV~96qDLj3COa0WfZVziawcQ2DLvX-eE6O9-9PUre-ta7ewFNOmbSnj8tlcZuUAyP2ipHPVOA~Fmccz3iWusJFOY4ccr~IGozq-05fe-a3~OCy210zIq3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Access_to_Ambulance_Services_for_People_with_Dementia_A_Comprehensive_Review_of_Facts_Challenges_Strategies_and_Future_Scopes","translated_slug":"","page_count":12,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":114191115,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/114191115/thumbnails/1.jpg","file_name":"gengpi.4.623.pdf","download_url":"https://www.academia.edu/attachments/114191115/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Access_to_Ambulance_Services_for_People.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/114191115/gengpi.4.623-libre.pdf?1714967168=\u0026response-content-disposition=attachment%3B+filename%3DAccess_to_Ambulance_Services_for_People.pdf\u0026Expires=1732758176\u0026Signature=Tfs~UlUmOhTOmiaHRu-SYSon8ieb-8XX6Jkh4q4BnY9iI~b-JFyZJ0frS5nW-6LW2G-czA-~gHFLo~O6j6kaGhzl-PgcKkf2dF-qnZ9TeyyOfjCKlz-LdkDzkmJVjB92U8-0poTH~NwTCIHV0Zpfb3Gg3FE2XCsR~v1l3ezY214mVXh9CbQLvazX8gRmQrqCnyDHFwehqojJWwYFE846jpVAYOunmT8zdV~96qDLj3COa0WfZVziawcQ2DLvX-eE6O9-9PUre-ta7ewFNOmbSnj8tlcZuUAyP2ipHPVOA~Fmccz3iWusJFOY4ccr~IGozq-05fe-a3~OCy210zIq3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="115714170"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/115714170/Evaluation_of_Cardiopulmonary_Resuscitation_CPR_Training_Programs_to_Schoolchildren_A_Comprehensive_Systematic_Review"><img alt="Research paper thumbnail of Evaluation of Cardiopulmonary Resuscitation (CPR) Training Programs to Schoolchildren: A Comprehensive Systematic Review" class="work-thumbnail" src="https://attachments.academia-assets.com/112510449/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/115714170/Evaluation_of_Cardiopulmonary_Resuscitation_CPR_Training_Programs_to_Schoolchildren_A_Comprehensive_Systematic_Review">Evaluation of Cardiopulmonary Resuscitation (CPR) Training Programs to Schoolchildren: A Comprehensive Systematic Review</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/IRHDJournal">IRHD Journal</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MajdShohreh">Shohreh Majd</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/MojcaBizjakMikic">Mojca Bizjak-Mikic</a></span></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cardiopulmonary resuscitation (CPR) is a lifesaving technique that holds immense significance in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cardiopulmonary resuscitation (CPR) is a lifesaving technique that holds immense significance in improving survival rates following cardiac arrest incidents. In the context of out-of-hospital cardiac arrest (OHCA), which remains a critical public health concern, the prompt initiation of CPR by bystanders significantly enhances the chances of survival. OHCA occurs suddenly and unexpectedly. Despite advancements in medical care, survival rates for OHCA remain low (Berdowski et al., 2010). According to Bystander CPR and Survival Rates, a study by Berdowski et al., the survival rate from OHCA in the US varied widely, ranging from</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6d16960355d0b2db8f46dbcd5f89df7b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112510449,"asset_id":115714170,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112510449/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="115714170"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="115714170"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 115714170; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=115714170]").text(description); $(".js-view-count[data-work-id=115714170]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 115714170; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='115714170']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 115714170, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6d16960355d0b2db8f46dbcd5f89df7b" } } $('.js-work-strip[data-work-id=115714170]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":115714170,"title":"Evaluation of Cardiopulmonary Resuscitation (CPR) Training Programs to Schoolchildren: A Comprehensive Systematic Review","translated_title":"","metadata":{"doi":"10.5281/zenodo.10828254","abstract":"Cardiopulmonary resuscitation (CPR) is a lifesaving technique that holds immense significance in improving survival rates following cardiac arrest incidents. In the context of out-of-hospital cardiac arrest (OHCA), which remains a critical public health concern, the prompt initiation of CPR by bystanders significantly enhances the chances of survival. OHCA occurs suddenly and unexpectedly. Despite advancements in medical care, survival rates for OHCA remain low (Berdowski et al., 2010). According to Bystander CPR and Survival Rates, a study by Berdowski et al., the survival rate from OHCA in the US varied widely, ranging from","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"Cardiopulmonary resuscitation (CPR) is a lifesaving technique that holds immense significance in improving survival rates following cardiac arrest incidents. In the context of out-of-hospital cardiac arrest (OHCA), which remains a critical public health concern, the prompt initiation of CPR by bystanders significantly enhances the chances of survival. OHCA occurs suddenly and unexpectedly. Despite advancements in medical care, survival rates for OHCA remain low (Berdowski et al., 2010). According to Bystander CPR and Survival Rates, a study by Berdowski et al., the survival rate from OHCA in the US varied widely, ranging from","internal_url":"https://www.academia.edu/115714170/Evaluation_of_Cardiopulmonary_Resuscitation_CPR_Training_Programs_to_Schoolchildren_A_Comprehensive_Systematic_Review","translated_internal_url":"","created_at":"2024-03-03T04:02:25.317-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41185643,"work_id":115714170,"tagging_user_id":282244998,"tagged_user_id":306498366,"co_author_invite_id":8076569,"email":"s***d@caa.net.au","display_order":1,"name":"Shohreh Majd","title":"Evaluation of Cardiopulmonary Resuscitation (CPR) Training Programs to Schoolchildren: A Comprehensive Systematic Review"},{"id":41185644,"work_id":115714170,"tagging_user_id":282244998,"tagged_user_id":305665511,"co_author_invite_id":8076570,"email":"d***s@caa.net.au","display_order":2,"name":"David Waters","title":"Evaluation of Cardiopulmonary Resuscitation (CPR) Training Programs to Schoolchildren: A Comprehensive Systematic Review"},{"id":41185645,"work_id":115714170,"tagging_user_id":282244998,"tagged_user_id":306085081,"co_author_invite_id":8076571,"email":"m***c@caa.net.au","display_order":3,"name":"Mojca Bizjak-Mikic","title":"Evaluation of Cardiopulmonary Resuscitation (CPR) Training Programs to Schoolchildren: A Comprehensive Systematic Review"}],"downloadable_attachments":[{"id":112510449,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112510449/thumbnails/1.jpg","file_name":"SchoolChirldren_CPR.docx.pdf","download_url":"https://www.academia.edu/attachments/112510449/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evaluation_of_Cardiopulmonary_Resuscitat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112510449/SchoolChirldren_CPR.docx-libre.pdf?1710720667=\u0026response-content-disposition=attachment%3B+filename%3DEvaluation_of_Cardiopulmonary_Resuscitat.pdf\u0026Expires=1732758176\u0026Signature=gDd1pt-MtfRIQlIeKSaGy9TwhpsZXcx2ks83uqV2qfvDXmu6DHOV2OM7PoRSD~ZxfvIzDJUBmoU3roYcOZt3STAY38lvxxgkrOngPLPwMfTqoVt913IoBzvzQxL66T2uMJcG2-GYZuQVs8g177-DZLzC6FZx-O2WnzGUbjsJkOghHCNToL3FFonkPMrHFFL8jk8IInBoRUVsQ85JI0tRVA62UL2~HCdHpgAdxRC7C4A~zGeYzq7iJ~0eUAx8pGIPml1DyK0XMDHUr3W1gSv49jg1T9-1QQ~aB-NHVCpD8lccsqFV-L1XHya0gN2EnPRlV~Uh06L7TNgqZVZDqQCRtA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Evaluation_of_Cardiopulmonary_Resuscitation_CPR_Training_Programs_to_Schoolchildren_A_Comprehensive_Systematic_Review","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":112510449,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112510449/thumbnails/1.jpg","file_name":"SchoolChirldren_CPR.docx.pdf","download_url":"https://www.academia.edu/attachments/112510449/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evaluation_of_Cardiopulmonary_Resuscitat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112510449/SchoolChirldren_CPR.docx-libre.pdf?1710720667=\u0026response-content-disposition=attachment%3B+filename%3DEvaluation_of_Cardiopulmonary_Resuscitat.pdf\u0026Expires=1732758176\u0026Signature=gDd1pt-MtfRIQlIeKSaGy9TwhpsZXcx2ks83uqV2qfvDXmu6DHOV2OM7PoRSD~ZxfvIzDJUBmoU3roYcOZt3STAY38lvxxgkrOngPLPwMfTqoVt913IoBzvzQxL66T2uMJcG2-GYZuQVs8g177-DZLzC6FZx-O2WnzGUbjsJkOghHCNToL3FFonkPMrHFFL8jk8IInBoRUVsQ85JI0tRVA62UL2~HCdHpgAdxRC7C4A~zGeYzq7iJ~0eUAx8pGIPml1DyK0XMDHUr3W1gSv49jg1T9-1QQ~aB-NHVCpD8lccsqFV-L1XHya0gN2EnPRlV~Uh06L7TNgqZVZDqQCRtA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":4441,"name":"Health Care","url":"https://www.academia.edu/Documents/in/Health_Care"},{"id":258680,"name":"Cardiopulmonary Resuscitation","url":"https://www.academia.edu/Documents/in/Cardiopulmonary_Resuscitation"},{"id":487398,"name":"Ambulance","url":"https://www.academia.edu/Documents/in/Ambulance"},{"id":836015,"name":"Studies on First Aid Awareness","url":"https://www.academia.edu/Documents/in/Studies_on_First_Aid_Awareness"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114616965"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114616965/Advancing_Childrens_Mental_Health_and_Wellbeing_Through_Healthcare_Policies"><img alt="Research paper thumbnail of Advancing Children's Mental Health and Wellbeing Through Healthcare Policies" class="work-thumbnail" src="https://attachments.academia-assets.com/111676280/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114616965/Advancing_Childrens_Mental_Health_and_Wellbeing_Through_Healthcare_Policies">Advancing Children's Mental Health and Wellbeing Through Healthcare Policies</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Children's mental health and wellbeing are fundamental components of their overall development an...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Children's mental health and wellbeing are fundamental components of their overall development and quality of life. Developing effective healthcare policies aimed at promoting and safeguarding children's mental health is crucial for addressing the growing challenges in this domain. That brings a need for a comprehensive examination of the different aspects and significance of healthcare policies focused on children's mental health and wellbeing, addressing these challenges. The various dimensions of policy development, implementation, and evaluation demand a holistic approach that integrates preventive, promotive, and therapeutic interventions. Drawing on insights from interdisciplinary fields such as psychology, public health, and policy analysis, this article offers practical and feasible recommendations for policymakers, healthcare practitioners, and researchers to enhance the effectiveness of children's mental health policies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="230171ae47346b2600f92c6088f60603" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111676280,"asset_id":114616965,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111676280/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114616965"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114616965"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114616965; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114616965]").text(description); $(".js-view-count[data-work-id=114616965]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114616965; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114616965']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114616965, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "230171ae47346b2600f92c6088f60603" } } $('.js-work-strip[data-work-id=114616965]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114616965,"title":"Advancing Children's Mental Health and Wellbeing Through Healthcare Policies","translated_title":"","metadata":{"doi":"10686046","issue":"1","volume":"2","abstract":"Children's mental health and wellbeing are fundamental components of their overall development and quality of life. Developing effective healthcare policies aimed at promoting and safeguarding children's mental health is crucial for addressing the growing challenges in this domain. That brings a need for a comprehensive examination of the different aspects and significance of healthcare policies focused on children's mental health and wellbeing, addressing these challenges. The various dimensions of policy development, implementation, and evaluation demand a holistic approach that integrates preventive, promotive, and therapeutic interventions. Drawing on insights from interdisciplinary fields such as psychology, public health, and policy analysis, this article offers practical and feasible recommendations for policymakers, healthcare practitioners, and researchers to enhance the effectiveness of children's mental health policies.","page_numbers":"29-39","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"Children's mental health and wellbeing are fundamental components of their overall development and quality of life. Developing effective healthcare policies aimed at promoting and safeguarding children's mental health is crucial for addressing the growing challenges in this domain. That brings a need for a comprehensive examination of the different aspects and significance of healthcare policies focused on children's mental health and wellbeing, addressing these challenges. The various dimensions of policy development, implementation, and evaluation demand a holistic approach that integrates preventive, promotive, and therapeutic interventions. Drawing on insights from interdisciplinary fields such as psychology, public health, and policy analysis, this article offers practical and feasible recommendations for policymakers, healthcare practitioners, and researchers to enhance the effectiveness of children's mental health policies.","internal_url":"https://www.academia.edu/114616965/Advancing_Childrens_Mental_Health_and_Wellbeing_Through_Healthcare_Policies","translated_internal_url":"","created_at":"2024-02-07T17:50:34.331-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41055790,"work_id":114616965,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":1,"name":"Shohreh Majd","title":"Advancing Children's Mental Health and Wellbeing Through Healthcare Policies"}],"downloadable_attachments":[{"id":111676280,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111676280/thumbnails/1.jpg","file_name":"5_Children_Mental_Health.pdf","download_url":"https://www.academia.edu/attachments/111676280/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Advancing_Childrens_Mental_Health_and_We.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111676280/5_Children_Mental_Health-libre.pdf?1708497737=\u0026response-content-disposition=attachment%3B+filename%3DAdvancing_Childrens_Mental_Health_and_We.pdf\u0026Expires=1732758176\u0026Signature=b-Sek8F1eU8iN5lOIk22nMlTUEKMiPcL5M0HWyYvmIY~mMLWerD5rjuMFl54Z85jhbXtuWFcxmI-Jht~MC2kJricN4pwy40pBfszg-ly39GJ~d~7E6WhwXE0UmLMl22V1WxEw52BauNHRXWGb4IQoVl-beJTvXojFIXe39u-3haUUFFH5c1TEIm3xf4FLvlbaiXwNdi-sdlYOJZAtmqj24c7B~XRH4N4H1FJAbVO3wdobdVA-8w2LGAxyd3aHOuUzw20w1GAUY~vvQwnUPfzsY0Q65fLjudElVTAnWgGnh5uopiGi75yDh4jLUzQJihAi8RshrIBcTOmIuCyvOyXeA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Advancing_Childrens_Mental_Health_and_Wellbeing_Through_Healthcare_Policies","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111676280,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111676280/thumbnails/1.jpg","file_name":"5_Children_Mental_Health.pdf","download_url":"https://www.academia.edu/attachments/111676280/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Advancing_Childrens_Mental_Health_and_We.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111676280/5_Children_Mental_Health-libre.pdf?1708497737=\u0026response-content-disposition=attachment%3B+filename%3DAdvancing_Childrens_Mental_Health_and_We.pdf\u0026Expires=1732758176\u0026Signature=b-Sek8F1eU8iN5lOIk22nMlTUEKMiPcL5M0HWyYvmIY~mMLWerD5rjuMFl54Z85jhbXtuWFcxmI-Jht~MC2kJricN4pwy40pBfszg-ly39GJ~d~7E6WhwXE0UmLMl22V1WxEw52BauNHRXWGb4IQoVl-beJTvXojFIXe39u-3haUUFFH5c1TEIm3xf4FLvlbaiXwNdi-sdlYOJZAtmqj24c7B~XRH4N4H1FJAbVO3wdobdVA-8w2LGAxyd3aHOuUzw20w1GAUY~vvQwnUPfzsY0Q65fLjudElVTAnWgGnh5uopiGi75yDh4jLUzQJihAi8RshrIBcTOmIuCyvOyXeA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":2827,"name":"Mental Health","url":"https://www.academia.edu/Documents/in/Mental_Health"},{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health"},{"id":29840,"name":"Public Policy Development","url":"https://www.academia.edu/Documents/in/Public_Policy_Development"},{"id":827809,"name":"Mental Health of Children and Young People","url":"https://www.academia.edu/Documents/in/Mental_Health_of_Children_and_Young_People"},{"id":979904,"name":"Publich Health Policy","url":"https://www.academia.edu/Documents/in/Publich_Health_Policy"}],"urls":[{"id":39655271,"url":"https://integratedrhd.com/2024-21-p29-39/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114569538"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114569538/Promoting_Public_Health_Trainings_in_Diverse_Communities"><img alt="Research paper thumbnail of Promoting Public Health Trainings in Diverse Communities" class="work-thumbnail" src="https://attachments.academia-assets.com/111675873/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114569538/Promoting_Public_Health_Trainings_in_Diverse_Communities">Promoting Public Health Trainings in Diverse Communities</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Public health trainings hold a pivotal role in bolstering communities against health challenges, ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Public health trainings hold a pivotal role in bolstering communities against health challenges, nurturing well-being, and fostering equitable access to healthcare. This article delves into the multifaceted significance of public health trainings, emphasizing their impact on enhancing health literacy, preventing diseases, and improving healthcare access across diverse communities. Through tailored interventions, individuals are empowered to make informed health decisions, cultivate healthy behaviours, and navigate intricate healthcare systems. These trainings address barriers to healthcare access and promote cultural competence, contributing to the establishment of inclusive healthcare ecosystems conducive to optimal health outcomes and societal resilience. Disseminating evidence-based information, fostering community engagement, and facilitating resource accessibility, public health trainings empower individuals to proactively enhance their health. Moreover, fostering collaboration between healthcare providers and community members, these initiatives bridge gaps in healthcare delivery, ensuring responsiveness to the unique needs of each population. Ultimately, public health trainings serve as linchpins of community health promotion, fostering empowerment, resilience, and equitable healthcare access for all.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3b4ab1d127d8e4e61afaab732f209f13" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111675873,"asset_id":114569538,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111675873/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114569538"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114569538"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114569538; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114569538]").text(description); $(".js-view-count[data-work-id=114569538]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114569538; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114569538']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114569538, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3b4ab1d127d8e4e61afaab732f209f13" } } $('.js-work-strip[data-work-id=114569538]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114569538,"title":"Promoting Public Health Trainings in Diverse Communities","translated_title":"","metadata":{"doi":"10.5281/zenodo.10686017","issue":"1","volume":"2","abstract":"Public health trainings hold a pivotal role in bolstering communities against health challenges, nurturing well-being, and fostering equitable access to healthcare. This article delves into the multifaceted significance of public health trainings, emphasizing their impact on enhancing health literacy, preventing diseases, and improving healthcare access across diverse communities. Through tailored interventions, individuals are empowered to make informed health decisions, cultivate healthy behaviours, and navigate intricate healthcare systems. These trainings address barriers to healthcare access and promote cultural competence, contributing to the establishment of inclusive healthcare ecosystems conducive to optimal health outcomes and societal resilience. Disseminating evidence-based information, fostering community engagement, and facilitating resource accessibility, public health trainings empower individuals to proactively enhance their health. Moreover, fostering collaboration between healthcare providers and community members, these initiatives bridge gaps in healthcare delivery, ensuring responsiveness to the unique needs of each population. Ultimately, public health trainings serve as linchpins of community health promotion, fostering empowerment, resilience, and equitable healthcare access for all.","page_numbers":"24-28","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"Public health trainings hold a pivotal role in bolstering communities against health challenges, nurturing well-being, and fostering equitable access to healthcare. This article delves into the multifaceted significance of public health trainings, emphasizing their impact on enhancing health literacy, preventing diseases, and improving healthcare access across diverse communities. Through tailored interventions, individuals are empowered to make informed health decisions, cultivate healthy behaviours, and navigate intricate healthcare systems. These trainings address barriers to healthcare access and promote cultural competence, contributing to the establishment of inclusive healthcare ecosystems conducive to optimal health outcomes and societal resilience. Disseminating evidence-based information, fostering community engagement, and facilitating resource accessibility, public health trainings empower individuals to proactively enhance their health. Moreover, fostering collaboration between healthcare providers and community members, these initiatives bridge gaps in healthcare delivery, ensuring responsiveness to the unique needs of each population. Ultimately, public health trainings serve as linchpins of community health promotion, fostering empowerment, resilience, and equitable healthcare access for all.","internal_url":"https://www.academia.edu/114569538/Promoting_Public_Health_Trainings_in_Diverse_Communities","translated_internal_url":"","created_at":"2024-02-06T15:34:12.024-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41050346,"work_id":114569538,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":8053328,"email":"a***6@gmail.com","display_order":2,"name":"Agarwal V","title":"Promoting Public Health Trainings in Diverse Communities"}],"downloadable_attachments":[{"id":111675873,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111675873/thumbnails/1.jpg","file_name":"4_Public_Health.pdf","download_url":"https://www.academia.edu/attachments/111675873/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Promoting_Public_Health_Trainings_in_Div.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111675873/4_Public_Health-libre.pdf?1708497808=\u0026response-content-disposition=attachment%3B+filename%3DPromoting_Public_Health_Trainings_in_Div.pdf\u0026Expires=1732758176\u0026Signature=AYus4ATPGqQKOCb4yiT2F4u~HUV9ni8rfDKBi-T4lYTUa7cO9pkat9pPdmwZM0en4LlGDjygR1c~AxdWthqdpcnAmQea242Q4dliW3DH371APxcu0wHlPAvd2RxC7jXmmPdXizzkF3Eqmwdd1yQtJKfSL4k5QlOsOY7B21j3ruhE48znP~f3NwLfAYpAkRM14oltZqFqAK15JrvgH~pcbdSXgaqtVDe4ohy71DmuS9KvIy8pws4RJh~JszyieJIWVjVd~kL8TYPpF6kh0qoWEUBGVBfTSw~LpVF-6UBX4BV04JH3TQVf~LYwKRBsxGiYoGauGz47Xds87TdrFCY~Fw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Promoting_Public_Health_Trainings_in_Diverse_Communities","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111675873,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111675873/thumbnails/1.jpg","file_name":"4_Public_Health.pdf","download_url":"https://www.academia.edu/attachments/111675873/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Promoting_Public_Health_Trainings_in_Div.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111675873/4_Public_Health-libre.pdf?1708497808=\u0026response-content-disposition=attachment%3B+filename%3DPromoting_Public_Health_Trainings_in_Div.pdf\u0026Expires=1732758176\u0026Signature=AYus4ATPGqQKOCb4yiT2F4u~HUV9ni8rfDKBi-T4lYTUa7cO9pkat9pPdmwZM0en4LlGDjygR1c~AxdWthqdpcnAmQea242Q4dliW3DH371APxcu0wHlPAvd2RxC7jXmmPdXizzkF3Eqmwdd1yQtJKfSL4k5QlOsOY7B21j3ruhE48znP~f3NwLfAYpAkRM14oltZqFqAK15JrvgH~pcbdSXgaqtVDe4ohy71DmuS9KvIy8pws4RJh~JszyieJIWVjVd~kL8TYPpF6kh0qoWEUBGVBfTSw~LpVF-6UBX4BV04JH3TQVf~LYwKRBsxGiYoGauGz47Xds87TdrFCY~Fw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":922,"name":"Education","url":"https://www.academia.edu/Documents/in/Education"},{"id":981,"name":"Health Promotion","url":"https://www.academia.edu/Documents/in/Health_Promotion"},{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health"},{"id":35646,"name":"Community Empowerment","url":"https://www.academia.edu/Documents/in/Community_Empowerment"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114529807"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114529807/The_Bidirectional_Relationship_Between_Depression_and_High_Blood_Pressure"><img alt="Research paper thumbnail of The Bidirectional Relationship Between Depression and High Blood Pressure" class="work-thumbnail" src="https://attachments.academia-assets.com/111675698/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114529807/The_Bidirectional_Relationship_Between_Depression_and_High_Blood_Pressure">The Bidirectional Relationship Between Depression and High Blood Pressure</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">High blood pressure (HBP) stands as a critical public health concern, given its pervasive nature ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">High blood pressure (HBP) stands as a critical public health concern, given its pervasive nature and the substantial morbidity and mortality associated with its complications, including cardiovascular diseases, stroke, and renal failure. With its silent and insidious progression, HBP often manifests asymptomatically. Concurrently, depression, a prevalent mental health disorder affecting millions worldwide, has emerged as a significant player in the intricate web of health-related interconnections. Extensive epidemiological evidence has shed light on the bidirectional relationship between depression and HBP, suggesting that individuals grappling with depression face an augmented risk of developing HBP, and conversely, those with HBP are more susceptible to depressive disorders. This intricate association is underscored by the intricate interplay of neurobiological, hormonal, and inflammatory mechanisms, fuelling a cycle that perpetuates the progression of both conditions. Here, we aim to provide a comprehensive synthesis of the existing scientific data and to promote a deeper understanding of this bidirectional relationship and illuminate avenues for targeted interventions that can concurrently address mental and cardiovascular health.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f940cb77978ff88978a76ce03ffa23f9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111675698,"asset_id":114529807,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111675698/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114529807"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114529807"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114529807; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114529807]").text(description); $(".js-view-count[data-work-id=114529807]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114529807; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114529807']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114529807, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f940cb77978ff88978a76ce03ffa23f9" } } $('.js-work-strip[data-work-id=114529807]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114529807,"title":"The Bidirectional Relationship Between Depression and High Blood Pressure","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685968","issue":"1","volume":"2","abstract":"High blood pressure (HBP) stands as a critical public health concern, given its pervasive nature and the substantial morbidity and mortality associated with its complications, including cardiovascular diseases, stroke, and renal failure. With its silent and insidious progression, HBP often manifests asymptomatically. Concurrently, depression, a prevalent mental health disorder affecting millions worldwide, has emerged as a significant player in the intricate web of health-related interconnections. Extensive epidemiological evidence has shed light on the bidirectional relationship between depression and HBP, suggesting that individuals grappling with depression face an augmented risk of developing HBP, and conversely, those with HBP are more susceptible to depressive disorders. This intricate association is underscored by the intricate interplay of neurobiological, hormonal, and inflammatory mechanisms, fuelling a cycle that perpetuates the progression of both conditions. Here, we aim to provide a comprehensive synthesis of the existing scientific data and to promote a deeper understanding of this bidirectional relationship and illuminate avenues for targeted interventions that can concurrently address mental and cardiovascular health.","page_numbers":"15-23","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"High blood pressure (HBP) stands as a critical public health concern, given its pervasive nature and the substantial morbidity and mortality associated with its complications, including cardiovascular diseases, stroke, and renal failure. With its silent and insidious progression, HBP often manifests asymptomatically. Concurrently, depression, a prevalent mental health disorder affecting millions worldwide, has emerged as a significant player in the intricate web of health-related interconnections. Extensive epidemiological evidence has shed light on the bidirectional relationship between depression and HBP, suggesting that individuals grappling with depression face an augmented risk of developing HBP, and conversely, those with HBP are more susceptible to depressive disorders. This intricate association is underscored by the intricate interplay of neurobiological, hormonal, and inflammatory mechanisms, fuelling a cycle that perpetuates the progression of both conditions. Here, we aim to provide a comprehensive synthesis of the existing scientific data and to promote a deeper understanding of this bidirectional relationship and illuminate avenues for targeted interventions that can concurrently address mental and cardiovascular health.","internal_url":"https://www.academia.edu/114529807/The_Bidirectional_Relationship_Between_Depression_and_High_Blood_Pressure","translated_internal_url":"","created_at":"2024-02-05T20:04:15.540-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41044850,"work_id":114529807,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":5,"name":"Shohreh Majd","title":"The Bidirectional Relationship Between Depression and High Blood Pressure"}],"downloadable_attachments":[{"id":111675698,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111675698/thumbnails/1.jpg","file_name":"3_Depression_and_HBP.pdf","download_url":"https://www.academia.edu/attachments/111675698/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Bidirectional_Relationship_Between_D.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111675698/3_Depression_and_HBP-libre.pdf?1708497845=\u0026response-content-disposition=attachment%3B+filename%3DThe_Bidirectional_Relationship_Between_D.pdf\u0026Expires=1732758176\u0026Signature=XzCH-gvuusa~a0X84~~x2RYXLy1eKBdZP~t09P36JoXYst1btsoxGW3NEtP-VMy6UeTvMRDLjB6lNiY9Qg-ej7PRLSQa9Y4LiLrBNm0d~0BkHiLw88qXNEM6YgXS24qiMQ-YsdZC~rRnSZ8AMClePzJaM~8xNvRwZdW0~APJYbNroOBD~tQZjxuHHGF60LnJ4F-1WLcoCOKUoai9d1si80EDEpGNIC07MWcAorUbPrz4OePW5miDIXgATnHBU4746IKN0O6afwsYlvFG7VQ2gU8-lvnHlBVOeUwzYmLXcxrfO2VCczgots4LXijnl-~PbkKGqhlaQ~eCeLzIuXjWAw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Bidirectional_Relationship_Between_Depression_and_High_Blood_Pressure","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111675698,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111675698/thumbnails/1.jpg","file_name":"3_Depression_and_HBP.pdf","download_url":"https://www.academia.edu/attachments/111675698/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Bidirectional_Relationship_Between_D.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111675698/3_Depression_and_HBP-libre.pdf?1708497845=\u0026response-content-disposition=attachment%3B+filename%3DThe_Bidirectional_Relationship_Between_D.pdf\u0026Expires=1732758176\u0026Signature=XzCH-gvuusa~a0X84~~x2RYXLy1eKBdZP~t09P36JoXYst1btsoxGW3NEtP-VMy6UeTvMRDLjB6lNiY9Qg-ej7PRLSQa9Y4LiLrBNm0d~0BkHiLw88qXNEM6YgXS24qiMQ-YsdZC~rRnSZ8AMClePzJaM~8xNvRwZdW0~APJYbNroOBD~tQZjxuHHGF60LnJ4F-1WLcoCOKUoai9d1si80EDEpGNIC07MWcAorUbPrz4OePW5miDIXgATnHBU4746IKN0O6afwsYlvFG7VQ2gU8-lvnHlBVOeUwzYmLXcxrfO2VCczgots4LXijnl-~PbkKGqhlaQ~eCeLzIuXjWAw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":168,"name":"Human Physiology","url":"https://www.academia.edu/Documents/in/Human_Physiology"},{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":2827,"name":"Mental Health","url":"https://www.academia.edu/Documents/in/Mental_Health"},{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension"},{"id":689957,"name":"Cardivascular Disease","url":"https://www.academia.edu/Documents/in/Cardivascular_Disease"}],"urls":[{"id":39654658,"url":"https://integratedrhd.com/2024-21-p15-23/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114321575"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114321575/The_Interplay_between_Chronic_Kidney_Disease_and_Dementia"><img alt="Research paper thumbnail of The Interplay between Chronic Kidney Disease and Dementia" class="work-thumbnail" src="https://attachments.academia-assets.com/111675283/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114321575/The_Interplay_between_Chronic_Kidney_Disease_and_Dementia">The Interplay between Chronic Kidney Disease and Dementia</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The interplay between chronic kidney disease (CKD) and dementia holds paramount significance in g...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The interplay between chronic kidney disease (CKD) and dementia holds paramount significance in global public health, given the prevalence and debilitating nature of these conditions. Recent evidence underscores a bidirectional relationship between kidney disease and cognitive impairment, emphasizing the need for in-depth exploration into shared risk factors and mechanistic pathways connecting these disorders. This article comprehensively reviews the intricate relationship between CKD and dementia, delving into the bidirectional link, shared risk factors, and mechanistic pathways inherent to these prevalent and debilitating conditions. Furthermore, we explore the impact of kidney disease on cognitive function and delves into the implications for patient care, providing a comprehensive overview of the multifaceted interconnection between CKD and dementia.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cd1286eaf1952d56dcd36b87ee6a7688" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111675283,"asset_id":114321575,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111675283/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114321575"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114321575"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114321575; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114321575]").text(description); $(".js-view-count[data-work-id=114321575]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114321575; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114321575']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114321575, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cd1286eaf1952d56dcd36b87ee6a7688" } } $('.js-work-strip[data-work-id=114321575]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114321575,"title":"The Interplay between Chronic Kidney Disease and Dementia","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685944","issue":"1","volume":"2","abstract":"The interplay between chronic kidney disease (CKD) and dementia holds paramount significance in global public health, given the prevalence and debilitating nature of these conditions. Recent evidence underscores a bidirectional relationship between kidney disease and cognitive impairment, emphasizing the need for in-depth exploration into shared risk factors and mechanistic pathways connecting these disorders. This article comprehensively reviews the intricate relationship between CKD and dementia, delving into the bidirectional link, shared risk factors, and mechanistic pathways inherent to these prevalent and debilitating conditions. Furthermore, we explore the impact of kidney disease on cognitive function and delves into the implications for patient care, providing a comprehensive overview of the multifaceted interconnection between CKD and dementia.","page_numbers":"7-14","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"The interplay between chronic kidney disease (CKD) and dementia holds paramount significance in global public health, given the prevalence and debilitating nature of these conditions. Recent evidence underscores a bidirectional relationship between kidney disease and cognitive impairment, emphasizing the need for in-depth exploration into shared risk factors and mechanistic pathways connecting these disorders. This article comprehensively reviews the intricate relationship between CKD and dementia, delving into the bidirectional link, shared risk factors, and mechanistic pathways inherent to these prevalent and debilitating conditions. Furthermore, we explore the impact of kidney disease on cognitive function and delves into the implications for patient care, providing a comprehensive overview of the multifaceted interconnection between CKD and dementia.","internal_url":"https://www.academia.edu/114321575/The_Interplay_between_Chronic_Kidney_Disease_and_Dementia","translated_internal_url":"","created_at":"2024-01-31T19:00:39.198-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":41017689,"work_id":114321575,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":2,"name":"Shohreh Majd","title":"The Interplay between Chronic Kidney Disease and Dementia"},{"id":41017688,"work_id":114321575,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":8047360,"email":"y***0@gmail.com","display_order":5,"name":"Yejun Jang","title":"The Interplay between Chronic Kidney Disease and Dementia"}],"downloadable_attachments":[{"id":111675283,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111675283/thumbnails/1.jpg","file_name":"2_CKD_Dementia.pdf","download_url":"https://www.academia.edu/attachments/111675283/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Interplay_between_Chronic_Kidney_Dis.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111675283/2_CKD_Dementia-libre.pdf?1708493766=\u0026response-content-disposition=attachment%3B+filename%3DThe_Interplay_between_Chronic_Kidney_Dis.pdf\u0026Expires=1732758176\u0026Signature=dNgSsPaTbxbbeQ1Qvc03lFYw10kAqw3aUjUQE49cHrekoJ4GyH8-PFXluBbUzXB0EYe4zKakjR7b4Xeg3vO7Fro2~KpRUvvwI4OyyHi454hiBkvUoa14~-nYmTq7sQ6v58QyuyXaZHleJ80uHH-gyRSqZFDo4d2D0CD4rob-z2Vj8bhjrErunfyl~hSwxGIdYtIzoj~ClWFS4f91Mk3BDJ2E5WJfEkJlgAtsiiWnYGJOjijwvHON7Ls13F8b5X6HmYEyR2jagP1Dpe~1yp9W7N54v1hpAxR8G-iAYVYaAvw8MEbCtoS5C5zhboEFR~0EwGBMrXcwfXM~9Jg0DBkX~g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Interplay_between_Chronic_Kidney_Disease_and_Dementia","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111675283,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111675283/thumbnails/1.jpg","file_name":"2_CKD_Dementia.pdf","download_url":"https://www.academia.edu/attachments/111675283/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_Interplay_between_Chronic_Kidney_Dis.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111675283/2_CKD_Dementia-libre.pdf?1708493766=\u0026response-content-disposition=attachment%3B+filename%3DThe_Interplay_between_Chronic_Kidney_Dis.pdf\u0026Expires=1732758176\u0026Signature=dNgSsPaTbxbbeQ1Qvc03lFYw10kAqw3aUjUQE49cHrekoJ4GyH8-PFXluBbUzXB0EYe4zKakjR7b4Xeg3vO7Fro2~KpRUvvwI4OyyHi454hiBkvUoa14~-nYmTq7sQ6v58QyuyXaZHleJ80uHH-gyRSqZFDo4d2D0CD4rob-z2Vj8bhjrErunfyl~hSwxGIdYtIzoj~ClWFS4f91Mk3BDJ2E5WJfEkJlgAtsiiWnYGJOjijwvHON7Ls13F8b5X6HmYEyR2jagP1Dpe~1yp9W7N54v1hpAxR8G-iAYVYaAvw8MEbCtoS5C5zhboEFR~0EwGBMrXcwfXM~9Jg0DBkX~g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3776,"name":"Alzheimer's Disease","url":"https://www.academia.edu/Documents/in/Alzheimers_Disease"},{"id":9001,"name":"Chronic kidney disease","url":"https://www.academia.edu/Documents/in/Chronic_kidney_disease"}],"urls":[{"id":39654247,"url":"https://integratedrhd.com/2024-21-p7-14/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="114176528"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/114176528/Prevalence_of_Periodontal_Disease_Its_Association_with_Systemic_Diseases_and_Prevention"><img alt="Research paper thumbnail of Prevalence of Periodontal Disease, Its Association with Systemic Diseases, and Prevention" class="work-thumbnail" src="https://attachments.academia-assets.com/111674943/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/114176528/Prevalence_of_Periodontal_Disease_Its_Association_with_Systemic_Diseases_and_Prevention">Prevalence of Periodontal Disease, Its Association with Systemic Diseases, and Prevention</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2024</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Periodontal disease is a prevalent oral health issue affecting a significant portion of the globa...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Periodontal disease is a prevalent oral health issue affecting a significant portion of the global population. The multifactorial etiology of periodontal disease involves dysregulated host responses to microbial biofilm, leading to progressive tissue destruction, ranging from reversible gingivitis to irreversible stages impacting periodontal ligament and alveolar bone. Variations in disease prevalence among populations underscore the influence of factors like age, gender, and socioeconomic status. Emphasizing the pivotal role of effective oral hygiene practices, this review delves into the global prevalence of periodontal disease, noting regional disparities influenced by cultural practices, socioeconomic conditions, and healthcare accessibility. Here we also explore the bidirectional relationship between periodontal disease and systemic conditions, focusing on diabetes mellitus, cardiovascular diseases, and rheumatoid arthritis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="610a3652b1b70d9477d65f94755850c0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111674943,"asset_id":114176528,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111674943/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="114176528"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="114176528"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 114176528; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=114176528]").text(description); $(".js-view-count[data-work-id=114176528]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 114176528; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='114176528']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 114176528, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "610a3652b1b70d9477d65f94755850c0" } } $('.js-work-strip[data-work-id=114176528]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":114176528,"title":"Prevalence of Periodontal Disease, Its Association with Systemic Diseases, and Prevention","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685921","abstract":"Periodontal disease is a prevalent oral health issue affecting a significant portion of the global population. The multifactorial etiology of periodontal disease involves dysregulated host responses to microbial biofilm, leading to progressive tissue destruction, ranging from reversible gingivitis to irreversible stages impacting periodontal ligament and alveolar bone. Variations in disease prevalence among populations underscore the influence of factors like age, gender, and socioeconomic status. Emphasizing the pivotal role of effective oral hygiene practices, this review delves into the global prevalence of periodontal disease, noting regional disparities influenced by cultural practices, socioeconomic conditions, and healthcare accessibility. Here we also explore the bidirectional relationship between periodontal disease and systemic conditions, focusing on diabetes mellitus, cardiovascular diseases, and rheumatoid arthritis.","publication_date":{"day":null,"month":null,"year":2024,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"Periodontal disease is a prevalent oral health issue affecting a significant portion of the global population. The multifactorial etiology of periodontal disease involves dysregulated host responses to microbial biofilm, leading to progressive tissue destruction, ranging from reversible gingivitis to irreversible stages impacting periodontal ligament and alveolar bone. Variations in disease prevalence among populations underscore the influence of factors like age, gender, and socioeconomic status. Emphasizing the pivotal role of effective oral hygiene practices, this review delves into the global prevalence of periodontal disease, noting regional disparities influenced by cultural practices, socioeconomic conditions, and healthcare accessibility. Here we also explore the bidirectional relationship between periodontal disease and systemic conditions, focusing on diabetes mellitus, cardiovascular diseases, and rheumatoid arthritis.","internal_url":"https://www.academia.edu/114176528/Prevalence_of_Periodontal_Disease_Its_Association_with_Systemic_Diseases_and_Prevention","translated_internal_url":"","created_at":"2024-01-28T20:02:42.854-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40999832,"work_id":114176528,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":8043848,"email":"a***o@outlook.com","display_order":3,"name":"F. Agra","title":"Prevalence of Periodontal Disease, Its Association with Systemic Diseases, and Prevention"}],"downloadable_attachments":[{"id":111674943,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111674943/thumbnails/1.jpg","file_name":"1_Prevalence_of_Periodontal_Disease.pdf","download_url":"https://www.academia.edu/attachments/111674943/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prevalence_of_Periodontal_Disease_Its_As.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111674943/1_Prevalence_of_Periodontal_Disease-libre.pdf?1708492508=\u0026response-content-disposition=attachment%3B+filename%3DPrevalence_of_Periodontal_Disease_Its_As.pdf\u0026Expires=1732758176\u0026Signature=b~5S2bBKs52PrL~vKJXBayBB8SPjPBv96n7ZBz9NJCm~8p5EQ7QRHEW7rzkBcH-MABhuLhp4IGsYE0myI3MehWNEgWuANZ4t1Mk9aUOGcDEvJnpy1QAfrnXh45bZeEk6lUuJ6MveLvG1EoEnpwHF0NryAu9E9o0OrcLKsyn0F-la36HKG-G7SEhse9-XMMzEWX2~8IlOi7Dkfm2HiJwSz7xMrAvppCgKu4deqF6Oe9DSCNTrlMaI5DiY8tkMkXKlMtolchzyWUyK2CrmqFkeqdhPYNzdR4Ym6wYniOycxf6I4Ni1VsaGmP8YPp~9Rdz~8bV1BYfSS82w9eDKm1Cc-Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Prevalence_of_Periodontal_Disease_Its_Association_with_Systemic_Diseases_and_Prevention","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111674943,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111674943/thumbnails/1.jpg","file_name":"1_Prevalence_of_Periodontal_Disease.pdf","download_url":"https://www.academia.edu/attachments/111674943/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prevalence_of_Periodontal_Disease_Its_As.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111674943/1_Prevalence_of_Periodontal_Disease-libre.pdf?1708492508=\u0026response-content-disposition=attachment%3B+filename%3DPrevalence_of_Periodontal_Disease_Its_As.pdf\u0026Expires=1732758176\u0026Signature=b~5S2bBKs52PrL~vKJXBayBB8SPjPBv96n7ZBz9NJCm~8p5EQ7QRHEW7rzkBcH-MABhuLhp4IGsYE0myI3MehWNEgWuANZ4t1Mk9aUOGcDEvJnpy1QAfrnXh45bZeEk6lUuJ6MveLvG1EoEnpwHF0NryAu9E9o0OrcLKsyn0F-la36HKG-G7SEhse9-XMMzEWX2~8IlOi7Dkfm2HiJwSz7xMrAvppCgKu4deqF6Oe9DSCNTrlMaI5DiY8tkMkXKlMtolchzyWUyK2CrmqFkeqdhPYNzdR4Ym6wYniOycxf6I4Ni1VsaGmP8YPp~9Rdz~8bV1BYfSS82w9eDKm1Cc-Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":12733,"name":"Rheumatoid Arthritis","url":"https://www.academia.edu/Documents/in/Rheumatoid_Arthritis"},{"id":24735,"name":"Cardiovascular disease","url":"https://www.academia.edu/Documents/in/Cardiovascular_disease"},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus"},{"id":419881,"name":"Oral Hygiene","url":"https://www.academia.edu/Documents/in/Oral_Hygiene"}],"urls":[{"id":39653884,"url":"https://integratedrhd.com/prevalence-of-periodontal-disease-its-association-with-systemic-diseases-and-prevention/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113801044"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113801044/Neuronal_response_in_Alzheimers_and_Parkinsons_disease_the_effect_of_toxic_proteins_on_intracellular_pathways"><img alt="Research paper thumbnail of Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways" class="work-thumbnail" src="https://attachments.academia-assets.com/110669837/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113801044/Neuronal_response_in_Alzheimers_and_Parkinsons_disease_the_effect_of_toxic_proteins_on_intracellular_pathways">Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways</a></div><div class="wp-workCard_item"><span>BMC neuroscience</span><span>, Jan 23, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Accumulation of protein aggregates is the leading cause of cellular dysfunction in neurodegenerat...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Accumulation of protein aggregates is the leading cause of cellular dysfunction in neurodegenerative disorders. Alzheimer&#39;s disease (AD), Parkinson&#39;s disease (PD), Huntington&#39;s disease, Prion disease and motor disorders such as amyotrophic lateral sclerosis, present with a similar pattern of progressive neuronal death, nervous system deterioration and cognitive impairment. The common characteristic is an unusual misfolding of proteins which is believed to cause protein deposition and trigger degenerative signals in the neurons. A similar clinical presentation seen in many neurodegenerative disorders suggests the possibility of shared neuronal responses in different disorders. Despite the difference in core elements of deposits in each neurodegenerative disorder, the cascade of neuronal reactions such as activation of glycogen synthase kinase-3 beta, mitogen-activated protein kinases, cell cycle re-entry and oxidative stress leading to a progressive neurodegeneration are ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4f7beb6cb6adf3789440126cfce5d43a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110669837,"asset_id":113801044,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110669837/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113801044"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113801044"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113801044; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113801044]").text(description); $(".js-view-count[data-work-id=113801044]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113801044; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113801044']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113801044, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4f7beb6cb6adf3789440126cfce5d43a" } } $('.js-work-strip[data-work-id=113801044]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113801044,"title":"Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways","translated_title":"","metadata":{"abstract":"Accumulation of protein aggregates is the leading cause of cellular dysfunction in neurodegenerative disorders. Alzheimer\u0026#39;s disease (AD), Parkinson\u0026#39;s disease (PD), Huntington\u0026#39;s disease, Prion disease and motor disorders such as amyotrophic lateral sclerosis, present with a similar pattern of progressive neuronal death, nervous system deterioration and cognitive impairment. The common characteristic is an unusual misfolding of proteins which is believed to cause protein deposition and trigger degenerative signals in the neurons. A similar clinical presentation seen in many neurodegenerative disorders suggests the possibility of shared neuronal responses in different disorders. Despite the difference in core elements of deposits in each neurodegenerative disorder, the cascade of neuronal reactions such as activation of glycogen synthase kinase-3 beta, mitogen-activated protein kinases, cell cycle re-entry and oxidative stress leading to a progressive neurodegeneration are ...","publication_date":{"day":23,"month":1,"year":2015,"errors":{}},"publication_name":"BMC neuroscience"},"translated_abstract":"Accumulation of protein aggregates is the leading cause of cellular dysfunction in neurodegenerative disorders. Alzheimer\u0026#39;s disease (AD), Parkinson\u0026#39;s disease (PD), Huntington\u0026#39;s disease, Prion disease and motor disorders such as amyotrophic lateral sclerosis, present with a similar pattern of progressive neuronal death, nervous system deterioration and cognitive impairment. The common characteristic is an unusual misfolding of proteins which is believed to cause protein deposition and trigger degenerative signals in the neurons. A similar clinical presentation seen in many neurodegenerative disorders suggests the possibility of shared neuronal responses in different disorders. Despite the difference in core elements of deposits in each neurodegenerative disorder, the cascade of neuronal reactions such as activation of glycogen synthase kinase-3 beta, mitogen-activated protein kinases, cell cycle re-entry and oxidative stress leading to a progressive neurodegeneration are ...","internal_url":"https://www.academia.edu/113801044/Neuronal_response_in_Alzheimers_and_Parkinsons_disease_the_effect_of_toxic_proteins_on_intracellular_pathways","translated_internal_url":"","created_at":"2024-01-20T21:06:12.927-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40979549,"work_id":113801044,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":0,"name":"Shohreh Majd","title":"Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways"}],"downloadable_attachments":[{"id":110669837,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110669837/thumbnails/1.jpg","file_name":"s12868-015-0211-1.pdf","download_url":"https://www.academia.edu/attachments/110669837/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Neuronal_response_in_Alzheimers_and_Park.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110669837/s12868-015-0211-1-libre.pdf?1705816913=\u0026response-content-disposition=attachment%3B+filename%3DNeuronal_response_in_Alzheimers_and_Park.pdf\u0026Expires=1732758176\u0026Signature=g-1dx8l6Wygcv1J7Wl3tgozwv5k2Htv7~P9DZ7xVG6GMqM26tfbJdInyFYNTCU8AwjElNszuh1InxIcLsoCdOTHcPaMy4k-vPnEi6WZQHaPPASd9hqGzwlzhAd3RHX0HKI~qfl2oXasNchTAxmgJMsKUdFfYEVYOIcOA-ym0hBtVYtPhPpPlUB9H1HNnOuoIbKYNnsJdz~bZOJpcYumI2Wk4eT1vXek2kA9jgfx8-jGYjSsb2a0kGuHKJAiZKz3oHuide1l-zPoPdCb9JzMTq77LUiNEmErnNiB1S1boUh2D2vaAackoNCk2bXq1l0glutM2u2PwtC8rXZUJ5TcLJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Neuronal_response_in_Alzheimers_and_Parkinsons_disease_the_effect_of_toxic_proteins_on_intracellular_pathways","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":110669837,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110669837/thumbnails/1.jpg","file_name":"s12868-015-0211-1.pdf","download_url":"https://www.academia.edu/attachments/110669837/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Niw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Neuronal_response_in_Alzheimers_and_Park.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110669837/s12868-015-0211-1-libre.pdf?1705816913=\u0026response-content-disposition=attachment%3B+filename%3DNeuronal_response_in_Alzheimers_and_Park.pdf\u0026Expires=1732758176\u0026Signature=g-1dx8l6Wygcv1J7Wl3tgozwv5k2Htv7~P9DZ7xVG6GMqM26tfbJdInyFYNTCU8AwjElNszuh1InxIcLsoCdOTHcPaMy4k-vPnEi6WZQHaPPASd9hqGzwlzhAd3RHX0HKI~qfl2oXasNchTAxmgJMsKUdFfYEVYOIcOA-ym0hBtVYtPhPpPlUB9H1HNnOuoIbKYNnsJdz~bZOJpcYumI2Wk4eT1vXek2kA9jgfx8-jGYjSsb2a0kGuHKJAiZKz3oHuide1l-zPoPdCb9JzMTq77LUiNEmErnNiB1S1boUh2D2vaAackoNCk2bXq1l0glutM2u2PwtC8rXZUJ5TcLJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience"},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":3971,"name":"Protein Folding","url":"https://www.academia.edu/Documents/in/Protein_Folding"},{"id":22764,"name":"Neurodegeneration","url":"https://www.academia.edu/Documents/in/Neurodegeneration"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":40538,"name":"Alpha Synuclein","url":"https://www.academia.edu/Documents/in/Alpha_Synuclein"},{"id":42973,"name":"Amyotrophic Lateral Sclerosis","url":"https://www.academia.edu/Documents/in/Amyotrophic_Lateral_Sclerosis"},{"id":125522,"name":"Neurotoxicity","url":"https://www.academia.edu/Documents/in/Neurotoxicity"},{"id":1120234,"name":"Alzheimer Disease","url":"https://www.academia.edu/Documents/in/Alzheimer_Disease"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1541077,"name":"Parkinson Disease","url":"https://www.academia.edu/Documents/in/Parkinson_Disease"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="113317194"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/113317194/Alzheimer_s_Disease_and_Cancer_When_Two_Monsters_Cannot_Be_Together"><img alt="Research paper thumbnail of Alzheimer’s Disease and Cancer: When Two Monsters Cannot Be Together" class="work-thumbnail" src="https://attachments.academia-assets.com/110307608/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/113317194/Alzheimer_s_Disease_and_Cancer_When_Two_Monsters_Cannot_Be_Together">Alzheimer’s Disease and Cancer: When Two Monsters Cannot Be Together</a></div><div class="wp-workCard_item"><span>Frontiers in Neuroscience</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1287009ae13086edb534035ae0214786" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":110307608,"asset_id":113317194,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/110307608/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="113317194"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="113317194"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 113317194; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=113317194]").text(description); $(".js-view-count[data-work-id=113317194]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 113317194; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='113317194']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 113317194, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1287009ae13086edb534035ae0214786" } } $('.js-work-strip[data-work-id=113317194]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":113317194,"title":"Alzheimer’s Disease and Cancer: When Two Monsters Cannot Be Together","translated_title":"","metadata":{"publisher":"Frontiers Media SA","grobid_abstract":"Alzheimer's disease (AD) and cancer are among the leading causes of human death around the world. While neurodegeneration is the main feature of AD, the most important characteristic of malignant tumors is cell proliferation, placing these two diseases in opposite sides of cell division spectrum. Interestingly, AD and cancer's pathologies consist of a remarkable common feature and that is the presence of active cell cycle in both conditions. In an in vitro model of primary adult neuronal culture, we previously showed that treating cell with beta amyloid forced neurons to start a cell cycle. Instead of cell division, however, neuronal cell cycle was aborted and a massive neurodegeneration was left behind as the consequence. A high level of cell cycle entry, which is a requirement for cancer pathogenesis, was reported in clinically diagnosed cases of AD, leading to neurodegeneration. The diverse clinical manifestation of a similar etiology, have puzzled researchers for many years. In fact, the evidence showed an inverse association between AD and cancer prevalence, suggesting that switching pathogenesis toward AD protects patients against cancer and vice versa. In this mini review, we discussed the possibility of involvement of cell proliferation and survival dysregulation as the underlying mechanism of neurodegeneration in AD, and the leading event to develop both disorders' pathology. As examples, the role of phosphoinositide 3 kinase/Akt/ mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway in cell cycle re-entry and blocking autophagy are discussed as potential common intracellular components between AD and cancer pathogenesis, with diverse clinical diagnosis.","publication_date":{"day":null,"month":null,"year":2019,"errors":{}},"publication_name":"Frontiers in Neuroscience","grobid_abstract_attachment_id":110307608},"translated_abstract":null,"internal_url":"https://www.academia.edu/113317194/Alzheimer_s_Disease_and_Cancer_When_Two_Monsters_Cannot_Be_Together","translated_internal_url":"","created_at":"2024-01-10T23:46:29.517-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40920231,"work_id":113317194,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":0,"name":"Shohreh Majd","title":"Alzheimer’s Disease and Cancer: When Two Monsters Cannot Be Together"}],"downloadable_attachments":[{"id":110307608,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110307608/thumbnails/1.jpg","file_name":"7b9d9497ba51e2f5d33f62e96a94eb93a614.pdf","download_url":"https://www.academia.edu/attachments/110307608/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alzheimer_s_Disease_and_Cancer_When_Two.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110307608/7b9d9497ba51e2f5d33f62e96a94eb93a614-libre.pdf?1704960434=\u0026response-content-disposition=attachment%3B+filename%3DAlzheimer_s_Disease_and_Cancer_When_Two.pdf\u0026Expires=1732758177\u0026Signature=QOZz4CCcTt1OBpCJ3J4uQADTdlgQ27RXPi0otr69NtanE6WNj0w6QsYvlKzic~JxED5LqKLhWl3xD8FFspl5bZS2jNWZ9hNsbLtXbjHkBH6h-FIm-Dt7PqXPvaT8eR7wu0H5GCKC-~YSXaSJQbrqbPu7WFypbrBYxHT4EvtIRfIuts0qlDFeF29M2CZLXjPu6zcnaLwtz9-AwQifedifgEI4OIBzjyEsrgdxQvnkc4Oc1dk9JRe0U-8r~xn3PhbdcoXw2Rrx8wCSSJ6alduxiv9ZAx31vgEZkUt6SHkCx2BCutgG3hekboiE9MV-CEvPYDUfkYOlapZrEP3AArS8Bg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Alzheimer_s_Disease_and_Cancer_When_Two_Monsters_Cannot_Be_Together","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":110307608,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/110307608/thumbnails/1.jpg","file_name":"7b9d9497ba51e2f5d33f62e96a94eb93a614.pdf","download_url":"https://www.academia.edu/attachments/110307608/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Alzheimer_s_Disease_and_Cancer_When_Two.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/110307608/7b9d9497ba51e2f5d33f62e96a94eb93a614-libre.pdf?1704960434=\u0026response-content-disposition=attachment%3B+filename%3DAlzheimer_s_Disease_and_Cancer_When_Two.pdf\u0026Expires=1732758177\u0026Signature=QOZz4CCcTt1OBpCJ3J4uQADTdlgQ27RXPi0otr69NtanE6WNj0w6QsYvlKzic~JxED5LqKLhWl3xD8FFspl5bZS2jNWZ9hNsbLtXbjHkBH6h-FIm-Dt7PqXPvaT8eR7wu0H5GCKC-~YSXaSJQbrqbPu7WFypbrBYxHT4EvtIRfIuts0qlDFeF29M2CZLXjPu6zcnaLwtz9-AwQifedifgEI4OIBzjyEsrgdxQvnkc4Oc1dk9JRe0U-8r~xn3PhbdcoXw2Rrx8wCSSJ6alduxiv9ZAx31vgEZkUt6SHkCx2BCutgG3hekboiE9MV-CEvPYDUfkYOlapZrEP3AArS8Bg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":161,"name":"Neuroscience","url":"https://www.academia.edu/Documents/in/Neuroscience"},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":9113,"name":"Cell Cycle","url":"https://www.academia.edu/Documents/in/Cell_Cycle"},{"id":22764,"name":"Neurodegeneration","url":"https://www.academia.edu/Documents/in/Neurodegeneration"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":295271,"name":"Protein kinase B","url":"https://www.academia.edu/Documents/in/Protein_kinase_B"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":38448412,"url":"https://www.frontiersin.org/article/10.3389/fnins.2019.00155/full"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112062765"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112062765/The_impact_of_tau_hyperphosphorylation_at_Ser_262_on_memory_and_learning_after_global_brain_ischaemia_in_a_rat_model_of_reversible_cardiac_arrest"><img alt="Research paper thumbnail of The impact of tau hyperphosphorylation at Ser 262 on memory and learning after global brain ischaemia in a rat model of reversible cardiac arrest" class="work-thumbnail" src="https://attachments.academia-assets.com/109409879/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112062765/The_impact_of_tau_hyperphosphorylation_at_Ser_262_on_memory_and_learning_after_global_brain_ischaemia_in_a_rat_model_of_reversible_cardiac_arrest">The impact of tau hyperphosphorylation at Ser 262 on memory and learning after global brain ischaemia in a rat model of reversible cardiac arrest</a></div><div class="wp-workCard_item"><span>IBRO Reports</span><span>, 2017</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e81603cb9ab5dc82b840cbe7ef973668" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109409879,"asset_id":112062765,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109409879/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112062765"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112062765"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112062765; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112062765]").text(description); $(".js-view-count[data-work-id=112062765]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112062765; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112062765']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 112062765, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e81603cb9ab5dc82b840cbe7ef973668" } } $('.js-work-strip[data-work-id=112062765]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112062765,"title":"The impact of tau hyperphosphorylation at Ser 262 on memory and learning after global brain ischaemia in a rat model of reversible cardiac arrest","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"The impact of tau hyperphosphorylation at Ser²⁶² on memory and learning after global brain ischaemia in a rat model of reversible cardiac arrest","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"IBRO Reports","grobid_abstract_attachment_id":109409879},"translated_abstract":null,"internal_url":"https://www.academia.edu/112062765/The_impact_of_tau_hyperphosphorylation_at_Ser_262_on_memory_and_learning_after_global_brain_ischaemia_in_a_rat_model_of_reversible_cardiac_arrest","translated_internal_url":"","created_at":"2023-12-22T03:27:48.668-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":109409879,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109409879/thumbnails/1.jpg","file_name":"hdl_109318.pdf","download_url":"https://www.academia.edu/attachments/109409879/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_impact_of_tau_hyperphosphorylation_a.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109409879/hdl_109318-libre.pdf?1703247340=\u0026response-content-disposition=attachment%3B+filename%3DThe_impact_of_tau_hyperphosphorylation_a.pdf\u0026Expires=1732758177\u0026Signature=A5RIFhNFW3A9o0vRddz9QcPWXyZjlvXqopdGcvLnX0-X~VAGjXECFBADtTqexH0Wzk5gen~uvahr77b0zLU3bbjVvmkHYxoRTtd9XIV8lzts6loo-t8Pwnqc98SFj1yQlPtdSoMg95BegOrZcmelEefgF3ZpLVIHgm99H8aXFNHSIAzVWWcxF-TYdYzsL5CBeNnWzHdSlgTvC~55Fh6t2F9kJqBlYiUkyd4vrhQ-0acKKBKlIJu6F-TLYojMmizKhSLjG4GnA~9VajRUSc98MuRF9a3yPK8hWiYkYbgmNDXdFJwftdcmAnq-qW05iKhbq9QY2WpT0z-8KX~97IKysg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_impact_of_tau_hyperphosphorylation_at_Ser_262_on_memory_and_learning_after_global_brain_ischaemia_in_a_rat_model_of_reversible_cardiac_arrest","translated_slug":"","page_count":14,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":109409879,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109409879/thumbnails/1.jpg","file_name":"hdl_109318.pdf","download_url":"https://www.academia.edu/attachments/109409879/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"The_impact_of_tau_hyperphosphorylation_a.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109409879/hdl_109318-libre.pdf?1703247340=\u0026response-content-disposition=attachment%3B+filename%3DThe_impact_of_tau_hyperphosphorylation_a.pdf\u0026Expires=1732758177\u0026Signature=A5RIFhNFW3A9o0vRddz9QcPWXyZjlvXqopdGcvLnX0-X~VAGjXECFBADtTqexH0Wzk5gen~uvahr77b0zLU3bbjVvmkHYxoRTtd9XIV8lzts6loo-t8Pwnqc98SFj1yQlPtdSoMg95BegOrZcmelEefgF3ZpLVIHgm99H8aXFNHSIAzVWWcxF-TYdYzsL5CBeNnWzHdSlgTvC~55Fh6t2F9kJqBlYiUkyd4vrhQ-0acKKBKlIJu6F-TLYojMmizKhSLjG4GnA~9VajRUSc98MuRF9a3yPK8hWiYkYbgmNDXdFJwftdcmAnq-qW05iKhbq9QY2WpT0z-8KX~97IKysg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":81065,"name":"Phosphatase","url":"https://www.academia.edu/Documents/in/Phosphatase"},{"id":172083,"name":"Phosphorylation","url":"https://www.academia.edu/Documents/in/Phosphorylation"},{"id":172084,"name":"AMPK","url":"https://www.academia.edu/Documents/in/AMPK"},{"id":223869,"name":"Protein Phosphatase 2A","url":"https://www.academia.edu/Documents/in/Protein_Phosphatase_2A"},{"id":247490,"name":"Kinase","url":"https://www.academia.edu/Documents/in/Kinase"},{"id":2928105,"name":"Tau protein","url":"https://www.academia.edu/Documents/in/Tau_protein"}],"urls":[{"id":37563984,"url":"https://api.elsevier.com/content/article/PII:S2451830116300243?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111374869"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111374869/Clinical_Features_of_Coronavirus_Infection_An_Updated_Review"><img alt="Research paper thumbnail of Clinical Features of Coronavirus Infection: An Updated Review" class="work-thumbnail" src="https://attachments.academia-assets.com/111674700/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111374869/Clinical_Features_of_Coronavirus_Infection_An_Updated_Review">Clinical Features of Coronavirus Infection: An Updated Review</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The coronavirus (CoV) family, particularly severe acute respiratory syndrome coronavirus 2 (SARS-...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The coronavirus (CoV) family, particularly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has garnered global attention due to the ongoing coronavirus disease 2019 (COVID-19) pandemic. This review article aims to provide an up-to-date overview of the clinical features associated with coronavirus infections. Here we explore the diverse manifestations of the disease, ranging from mild respiratory symptoms to severe respiratory distress and multi-organ dysfunction. Additionally, we discuss the latest advancements in our understanding of the clinical spectrum, risk factors, and long-term sequelae associated with COVID-19.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fbb296d0ef382ff0be777563f014abb8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111674700,"asset_id":111374869,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111674700/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111374869"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111374869"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111374869; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111374869]").text(description); $(".js-view-count[data-work-id=111374869]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111374869; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111374869']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111374869, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fbb296d0ef382ff0be777563f014abb8" } } $('.js-work-strip[data-work-id=111374869]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111374869,"title":"Clinical Features of Coronavirus Infection: An Updated Review","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685879","issue":"2","volume":"1","abstract":"The coronavirus (CoV) family, particularly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has garnered global attention due to the ongoing coronavirus disease 2019 (COVID-19) pandemic. This review article aims to provide an up-to-date overview of the clinical features associated with coronavirus infections. Here we explore the diverse manifestations of the disease, ranging from mild respiratory symptoms to severe respiratory distress and multi-organ dysfunction. Additionally, we discuss the latest advancements in our understanding of the clinical spectrum, risk factors, and long-term sequelae associated with COVID-19.","page_numbers":"32-38","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"The coronavirus (CoV) family, particularly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has garnered global attention due to the ongoing coronavirus disease 2019 (COVID-19) pandemic. This review article aims to provide an up-to-date overview of the clinical features associated with coronavirus infections. Here we explore the diverse manifestations of the disease, ranging from mild respiratory symptoms to severe respiratory distress and multi-organ dysfunction. Additionally, we discuss the latest advancements in our understanding of the clinical spectrum, risk factors, and long-term sequelae associated with COVID-19.","internal_url":"https://www.academia.edu/111374869/Clinical_Features_of_Coronavirus_Infection_An_Updated_Review","translated_internal_url":"","created_at":"2023-12-13T21:05:38.510-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40712286,"work_id":111374869,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":1,"name":"Shohreh Majd","title":"Clinical Features of Coronavirus Infection: An Updated Review"},{"id":40712285,"work_id":111374869,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":7989393,"email":"d***i@gmail.com","display_order":10,"name":"Li Y","title":"Clinical Features of Coronavirus Infection: An Updated Review"}],"downloadable_attachments":[{"id":111674700,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111674700/thumbnails/1.jpg","file_name":"6_Clinical_Features_of_Coronavirus_Infection_An_Updated_Review.pdf","download_url":"https://www.academia.edu/attachments/111674700/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_Features_of_Coronavirus_Infecti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111674700/6_Clinical_Features_of_Coronavirus_Infection_An_Updated_Review-libre.pdf?1708492550=\u0026response-content-disposition=attachment%3B+filename%3DClinical_Features_of_Coronavirus_Infecti.pdf\u0026Expires=1732758177\u0026Signature=Hcr52y9kx~LstXY8LG9u0H6n6VphlEqC7Y2rOVW~bMTtNOZVj3Ja2Dp6UUR5WuC1ZN-8VTtH33zHUymubcnBsTvcIzcnhZdDvkysZWoPPcjezzI9Rdp356bmKz6pYSXzpZr04aHohiaucH9ir5NCXqgDEyAw8Ai6rGVaFCe49ijC7bMqBYbPcW0h2kHtOa-EPgW9YZBzxLMabyUDz0FN2eyUqV3aGWmLOq1v1xMx8UKXQL1GuhbFAPHrVRShzFYvdPZR~Cdg-e-QHyvE1lkpXrMQNOe-A-X1M1YKRyBITqEnErlWMZjMKAY8Lxh~J5XlxPED7IGhw~GD27JcL5gzIw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Clinical_Features_of_Coronavirus_Infection_An_Updated_Review","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111674700,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111674700/thumbnails/1.jpg","file_name":"6_Clinical_Features_of_Coronavirus_Infection_An_Updated_Review.pdf","download_url":"https://www.academia.edu/attachments/111674700/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Clinical_Features_of_Coronavirus_Infecti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111674700/6_Clinical_Features_of_Coronavirus_Infection_An_Updated_Review-libre.pdf?1708492550=\u0026response-content-disposition=attachment%3B+filename%3DClinical_Features_of_Coronavirus_Infecti.pdf\u0026Expires=1732758177\u0026Signature=Hcr52y9kx~LstXY8LG9u0H6n6VphlEqC7Y2rOVW~bMTtNOZVj3Ja2Dp6UUR5WuC1ZN-8VTtH33zHUymubcnBsTvcIzcnhZdDvkysZWoPPcjezzI9Rdp356bmKz6pYSXzpZr04aHohiaucH9ir5NCXqgDEyAw8Ai6rGVaFCe49ijC7bMqBYbPcW0h2kHtOa-EPgW9YZBzxLMabyUDz0FN2eyUqV3aGWmLOq1v1xMx8UKXQL1GuhbFAPHrVRShzFYvdPZR~Cdg-e-QHyvE1lkpXrMQNOe-A-X1M1YKRyBITqEnErlWMZjMKAY8Lxh~J5XlxPED7IGhw~GD27JcL5gzIw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":16288,"name":"Public Health","url":"https://www.academia.edu/Documents/in/Public_Health"},{"id":17960,"name":"Infectious Diseases","url":"https://www.academia.edu/Documents/in/Infectious_Diseases"},{"id":385972,"name":"Immunocompromised host","url":"https://www.academia.edu/Documents/in/Immunocompromised_host"}],"urls":[{"id":39653668,"url":"https://integratedrhd.com/2023-12-p27-31-2/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111290830"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111290830/A_comparison_of_LKB1_AMPK_mTOR_metabolic_axis_response_to_global_ischaemia_in_brain_heart_liver_and_kidney_in_a_rat_model_of_cardiac_arrest"><img alt="Research paper thumbnail of A comparison of LKB1/AMPK/mTOR metabolic axis response to global ischaemia in brain, heart, liver and kidney in a rat model of cardiac arrest" class="work-thumbnail" src="https://attachments.academia-assets.com/108869647/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111290830/A_comparison_of_LKB1_AMPK_mTOR_metabolic_axis_response_to_global_ischaemia_in_brain_heart_liver_and_kidney_in_a_rat_model_of_cardiac_arrest">A comparison of LKB1/AMPK/mTOR metabolic axis response to global ischaemia in brain, heart, liver and kidney in a rat model of cardiac arrest</a></div><div class="wp-workCard_item"><span>BMC Cell Biology</span><span>, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ce03e8d99fd34735621fcf89373c52af" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108869647,"asset_id":111290830,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108869647/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111290830"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111290830"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111290830; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111290830]").text(description); $(".js-view-count[data-work-id=111290830]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111290830; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111290830']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111290830, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ce03e8d99fd34735621fcf89373c52af" } } $('.js-work-strip[data-work-id=111290830]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111290830,"title":"A comparison of LKB1/AMPK/mTOR metabolic axis response to global ischaemia in brain, heart, liver and kidney in a rat model of cardiac arrest","translated_title":"","metadata":{"publisher":"Springer Science and Business Media LLC","grobid_abstract":"Background: Cellular energy failure in high metabolic rate organs is one of the underlying causes for many disorders such as neurodegenerative diseases, cardiomyopathies, liver and renal failures. In the past decade, numerous studies have discovered the cellular axis of LKB1/AMPK/mTOR as an essential modulator of cell homeostasis in response to energy stress. Through regulating adaptive mechanisms, this axis adjusts the energy availability to its demand by a systematized control on metabolism. Energy stress, however, could be sensed at different levels in various tissues, leading to applying different strategies in response to hypoxic insults. Methods: Here the immediate strategies of high metabolic rate organs to time-dependent short episodes of ischaemia were studied by using a rat model (n = 6/group) of cardiac arrest (CA) (15 and 30 s, 1, 2, 4 and 8 min CA). Using western blot analysis, we examined the responses of LKB1/AMPK/mTOR pathway in brain, heart, liver and kidney from 15 s up to 8 min of global ischaemia. The ratio of ADP/ATP was assessed in all ischemic and control groups, using ApoSENSOR bioluminescent assay kit. Results: Brain, followed by kidney showed the early dephosphorylation response in AMPK (Thr 172) and LKB1 (Ser 431); in the absence of ATP decline (ADP/ATP elevation). Dephosphorylation of AMPK was followed by rephosphorylation and hyperphosphorylation, which was associated with a significant ATP decline. While heart's activity of AMPK and LKB1 remained at the same level during short episodes of ischaemia, liver's LKB1 was dephosphorylated after 2 min. AMPK response to ischaemia in liver was mainly based on an early alternative and a late constant hyperphosphorylation. No significant changes was observed in mTOR activity in all groups. Conclusion: Together our results suggest that early AMPK dephosphorylation followed by late hyperphosphorylation is the strategy of brain and kidney in response to ischaemia. While the liver seemed to get benefit of its AMPK system in early ischameia, possibly to stabilize ATP, the level of LKB1/AMPK activity in heart remained unchanged in short ischaemic episodes up to 8 min. Further researches must be conducted to elucidate the molecular mechanism underlying LKB1/AMPK response to oxygen supply.","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"BMC Cell Biology","grobid_abstract_attachment_id":108869647},"translated_abstract":null,"internal_url":"https://www.academia.edu/111290830/A_comparison_of_LKB1_AMPK_mTOR_metabolic_axis_response_to_global_ischaemia_in_brain_heart_liver_and_kidney_in_a_rat_model_of_cardiac_arrest","translated_internal_url":"","created_at":"2023-12-12T22:24:28.897-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":108869647,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108869647/thumbnails/1.jpg","file_name":"s12860-018-0159-y.pdf","download_url":"https://www.academia.edu/attachments/108869647/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_comparison_of_LKB1_AMPK_mTOR_metabolic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108869647/s12860-018-0159-y-libre.pdf?1702452247=\u0026response-content-disposition=attachment%3B+filename%3DA_comparison_of_LKB1_AMPK_mTOR_metabolic.pdf\u0026Expires=1732758177\u0026Signature=VGBi1og~7K2m~zuWluBPH0wUK1TX8CY7n7iYKTkZlzpTM4azf21bQLI30wHSUZNEkTNDTU87Phusc3U~Z8ysaHlUWznlVwS49iMrPyUQ1kIvNXeIsmoxTAMEuphkzdIINaZkVqM2I4a-T9ywjE7alcfkOjxq3ld2EAn8OHAIJ3bntvd3QKuqL73pKHEnWN8MA5b3oqc5VuH~Q~WxFT3p8fnFvbfTdHKh2drV3pSUysRcPjv1rfJYTBrjGHY33klk6yejf8IEkQsfPAxGrQZlxRmewlckVgSmOxS5jnpz5yuik5hos0B3sG2~qMRbmpPIavcVYQUUMqztFovMx7Typg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"A_comparison_of_LKB1_AMPK_mTOR_metabolic_axis_response_to_global_ischaemia_in_brain_heart_liver_and_kidney_in_a_rat_model_of_cardiac_arrest","translated_slug":"","page_count":12,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":108869647,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108869647/thumbnails/1.jpg","file_name":"s12860-018-0159-y.pdf","download_url":"https://www.academia.edu/attachments/108869647/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"A_comparison_of_LKB1_AMPK_mTOR_metabolic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108869647/s12860-018-0159-y-libre.pdf?1702452247=\u0026response-content-disposition=attachment%3B+filename%3DA_comparison_of_LKB1_AMPK_mTOR_metabolic.pdf\u0026Expires=1732758177\u0026Signature=VGBi1og~7K2m~zuWluBPH0wUK1TX8CY7n7iYKTkZlzpTM4azf21bQLI30wHSUZNEkTNDTU87Phusc3U~Z8ysaHlUWznlVwS49iMrPyUQ1kIvNXeIsmoxTAMEuphkzdIINaZkVqM2I4a-T9ywjE7alcfkOjxq3ld2EAn8OHAIJ3bntvd3QKuqL73pKHEnWN8MA5b3oqc5VuH~Q~WxFT3p8fnFvbfTdHKh2drV3pSUysRcPjv1rfJYTBrjGHY33klk6yejf8IEkQsfPAxGrQZlxRmewlckVgSmOxS5jnpz5yuik5hos0B3sG2~qMRbmpPIavcVYQUUMqztFovMx7Typg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":108869646,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108869646/thumbnails/1.jpg","file_name":"s12860-018-0159-y.pdf","download_url":"https://www.academia.edu/attachments/108869646/download_file","bulk_download_file_name":"A_comparison_of_LKB1_AMPK_mTOR_metabolic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108869646/s12860-018-0159-y-libre.pdf?1702452250=\u0026response-content-disposition=attachment%3B+filename%3DA_comparison_of_LKB1_AMPK_mTOR_metabolic.pdf\u0026Expires=1732758177\u0026Signature=I~GKygN7hwACAFr2siFpgSnhVMm0Ma5DNOwMq4d11A8qxhTS6M3iU7~lYwg~jhjLZKdy-SZERr3QVE1AQVJOYuioOQzSB6cJkwWNmlSvsBg3U5D48-EZH13ojGgcxciyXv0RXOophRlw41XQh45i5GEzJ5tQaQCAr6yaxF9wRE0kXfu7w2TylEPqnz1~mWcegIhS7QNpeGYSIz3KbHqBpdKS~rj2atTZ5xPLmIMArwfB8kHocIEphny8WqAsqgv6JxqR1L1Y38CEFkSGhzyowF4hJluj~X0KJuqxklm8k-t2qJiRTOgz9NSa00bAnThRO-s6AR8eWdWzmJrPB00m9Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":61235,"name":"Cardiac arrest","url":"https://www.academia.edu/Documents/in/Cardiac_arrest"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":82983,"name":"Ischemia","url":"https://www.academia.edu/Documents/in/Ischemia"},{"id":91391,"name":"mTOR","url":"https://www.academia.edu/Documents/in/mTOR"},{"id":172084,"name":"AMPK","url":"https://www.academia.edu/Documents/in/AMPK"},{"id":462111,"name":"Western blot","url":"https://www.academia.edu/Documents/in/Western_blot"},{"id":465842,"name":"Ischaemia","url":"https://www.academia.edu/Documents/in/Ischaemia"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":1953129,"name":"Dephosphorylation","url":"https://www.academia.edu/Documents/in/Dephosphorylation"}],"urls":[{"id":36990827,"url":"http://link.springer.com/content/pdf/10.1186/s12860-018-0159-y.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110602069"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110602069/Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis"><img alt="Research paper thumbnail of Decoding the Intricate Roles of Vitamin D in Bone Health: Beyond Calcium Homeostasis" class="work-thumbnail" src="https://attachments.academia-assets.com/111674248/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110602069/Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis">Decoding the Intricate Roles of Vitamin D in Bone Health: Beyond Calcium Homeostasis</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The intricate relationship between vitamin D and bone health encompasses a diverse spectrum of ro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The intricate relationship between vitamin D and bone health encompasses a diverse spectrum of roles, extending far beyond its classical functions in calcium homeostasis. Apart from the classical role of vitamin D in maintaining calcium homeostasis, it involves in intricate intracellular processes that contribute significantly to bone health. This includes modulation of oxidative stress, with vitamin D receptors in osteoblasts and osteoclasts regulating antioxidant enzymes, safeguarding bone cells from oxidative damage. Vitamin D's influence extends to energy metabolism, impacting adipocytes and muscle cells directly. Deficiency is associated with increased adiposity and altered muscle function, emphasizing its regulatory role in adipogenesis, lipolysis, and muscle protein synthesis. This intricate interplay highlights vitamin D's expanded role beyond calcium homeostasis. Vitamin D also emerges as a crucial regulator in promoting the anabolic state of bone. It enhances osteoblast differentiation and mineralization through intricate signalling pathways, ensuring proper bone formation. Simultaneously, it modulates the expression of growth factors and cytokines, promoting bone formation while inhibiting factors associated with bone resorption. Here we explore the multifaceted impact of vitamin D on bone and its role in preserving skeletal integrity. The review extends to discuss the preventive role of vitamin D in the catabolic state of bone, where bone resorption surpasses formation. Vitamin D's regulatory control over factors such as RANKL and OPG plays a pivotal role in maintaining skeletal integrity, preventing bone loss.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7b3e3c8ce95e8e42d13df8ca5b2b4adf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111674248,"asset_id":110602069,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111674248/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110602069"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110602069"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110602069; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110602069]").text(description); $(".js-view-count[data-work-id=110602069]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110602069; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110602069']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110602069, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7b3e3c8ce95e8e42d13df8ca5b2b4adf" } } $('.js-work-strip[data-work-id=110602069]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110602069,"title":"Decoding the Intricate Roles of Vitamin D in Bone Health: Beyond Calcium Homeostasis","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685856","issue":"2","volume":"1","abstract":"The intricate relationship between vitamin D and bone health encompasses a diverse spectrum of roles, extending far beyond its classical functions in calcium homeostasis. Apart from the classical role of vitamin D in maintaining calcium homeostasis, it involves in intricate intracellular processes that contribute significantly to bone health. This includes modulation of oxidative stress, with vitamin D receptors in osteoblasts and osteoclasts regulating antioxidant enzymes, safeguarding bone cells from oxidative damage. Vitamin D's influence extends to energy metabolism, impacting adipocytes and muscle cells directly. Deficiency is associated with increased adiposity and altered muscle function, emphasizing its regulatory role in adipogenesis, lipolysis, and muscle protein synthesis. This intricate interplay highlights vitamin D's expanded role beyond calcium homeostasis. Vitamin D also emerges as a crucial regulator in promoting the anabolic state of bone. It enhances osteoblast differentiation and mineralization through intricate signalling pathways, ensuring proper bone formation. Simultaneously, it modulates the expression of growth factors and cytokines, promoting bone formation while inhibiting factors associated with bone resorption. Here we explore the multifaceted impact of vitamin D on bone and its role in preserving skeletal integrity. The review extends to discuss the preventive role of vitamin D in the catabolic state of bone, where bone resorption surpasses formation. Vitamin D's regulatory control over factors such as RANKL and OPG plays a pivotal role in maintaining skeletal integrity, preventing bone loss.","ai_title_tag":"Vitamin D's Multifaceted Role in Bone Health and Integrity","page_numbers":"27-31","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"The intricate relationship between vitamin D and bone health encompasses a diverse spectrum of roles, extending far beyond its classical functions in calcium homeostasis. Apart from the classical role of vitamin D in maintaining calcium homeostasis, it involves in intricate intracellular processes that contribute significantly to bone health. This includes modulation of oxidative stress, with vitamin D receptors in osteoblasts and osteoclasts regulating antioxidant enzymes, safeguarding bone cells from oxidative damage. Vitamin D's influence extends to energy metabolism, impacting adipocytes and muscle cells directly. Deficiency is associated with increased adiposity and altered muscle function, emphasizing its regulatory role in adipogenesis, lipolysis, and muscle protein synthesis. This intricate interplay highlights vitamin D's expanded role beyond calcium homeostasis. Vitamin D also emerges as a crucial regulator in promoting the anabolic state of bone. It enhances osteoblast differentiation and mineralization through intricate signalling pathways, ensuring proper bone formation. Simultaneously, it modulates the expression of growth factors and cytokines, promoting bone formation while inhibiting factors associated with bone resorption. Here we explore the multifaceted impact of vitamin D on bone and its role in preserving skeletal integrity. The review extends to discuss the preventive role of vitamin D in the catabolic state of bone, where bone resorption surpasses formation. Vitamin D's regulatory control over factors such as RANKL and OPG plays a pivotal role in maintaining skeletal integrity, preventing bone loss.","internal_url":"https://www.academia.edu/110602069/Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis","translated_internal_url":"","created_at":"2023-12-04T23:40:49.911-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40648050,"work_id":110602069,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":7976704,"email":"g***2@gmail.com","display_order":4,"name":"Sharma Kaur","title":"Decoding the Intricate Roles of Vitamin D in Bone Health: Beyond Calcium Homeostasis"}],"downloadable_attachments":[{"id":111674248,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111674248/thumbnails/1.jpg","file_name":"5_Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis.pdf","download_url":"https://www.academia.edu/attachments/111674248/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Decoding_the_Intricate_Roles_of_Vitamin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111674248/5_Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis-libre.pdf?1708492615=\u0026response-content-disposition=attachment%3B+filename%3DDecoding_the_Intricate_Roles_of_Vitamin.pdf\u0026Expires=1732758177\u0026Signature=JMaKueGEOPTFhVfWzeEnLthVhJFsmVKMqIQNiQl5JwtRCK5yub3xM8WpCVMOggy0W1lIB4-jCguJz9wYC8cs1qaJLaurxBjwhEW4hCr2LzQf3s1TiV06G6W224xqGK3PZx0JbPOmVTfSG2cLQI93xO-5JR0E~yFjqL8GgQuEtURgsJ2E5xOkr7GsWHpx4c2u2nOzw5KuNewXusoQV7P6O5rZDTR22Ui5f7skN5NGwy1PFySAi3jY7QYuVNRoSyY4duff1-V5FrzSkV9b7rwdGDf20W4aiFxbuXRGkZl6lfJ8hVCYvT-zv8~wgsadn6-HGjb7Opg8rVEK1iTGvSV--w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis","translated_slug":"","page_count":5,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111674248,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111674248/thumbnails/1.jpg","file_name":"5_Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis.pdf","download_url":"https://www.academia.edu/attachments/111674248/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Decoding_the_Intricate_Roles_of_Vitamin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111674248/5_Decoding_the_Intricate_Roles_of_Vitamin_D_in_Bone_Health_Beyond_Calcium_Homeostasis-libre.pdf?1708492615=\u0026response-content-disposition=attachment%3B+filename%3DDecoding_the_Intricate_Roles_of_Vitamin.pdf\u0026Expires=1732758177\u0026Signature=JMaKueGEOPTFhVfWzeEnLthVhJFsmVKMqIQNiQl5JwtRCK5yub3xM8WpCVMOggy0W1lIB4-jCguJz9wYC8cs1qaJLaurxBjwhEW4hCr2LzQf3s1TiV06G6W224xqGK3PZx0JbPOmVTfSG2cLQI93xO-5JR0E~yFjqL8GgQuEtURgsJ2E5xOkr7GsWHpx4c2u2nOzw5KuNewXusoQV7P6O5rZDTR22Ui5f7skN5NGwy1PFySAi3jY7QYuVNRoSyY4duff1-V5FrzSkV9b7rwdGDf20W4aiFxbuXRGkZl6lfJ8hVCYvT-zv8~wgsadn6-HGjb7Opg8rVEK1iTGvSV--w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1040,"name":"Food Science","url":"https://www.academia.edu/Documents/in/Food_Science"},{"id":9531,"name":"Vitamin D","url":"https://www.academia.edu/Documents/in/Vitamin_D"},{"id":10221,"name":"Food and Nutrition","url":"https://www.academia.edu/Documents/in/Food_and_Nutrition"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":36213,"name":"Energy Metabolism","url":"https://www.academia.edu/Documents/in/Energy_Metabolism"},{"id":70883,"name":"Bone health","url":"https://www.academia.edu/Documents/in/Bone_health"}],"urls":[{"id":39653264,"url":"https://integratedrhd.com/2023-12-p27-31/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110598756"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110598756/Optimizing_Healthcare_Project_Management_with_Positive_Psychology"><img alt="Research paper thumbnail of Optimizing Healthcare Project Management with Positive Psychology" class="work-thumbnail" src="https://attachments.academia-assets.com/111672546/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110598756/Optimizing_Healthcare_Project_Management_with_Positive_Psychology">Optimizing Healthcare Project Management with Positive Psychology</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">As healthcare organizations navigate the complexities of the industry, project managers play a ce...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">As healthcare organizations navigate the complexities of the industry, project managers play a central role in optimizing patient care and operational processes. In such dynamic setting, positive psychology emerges as a paradigm, offering a holistic framework that extends beyond traditional project management methodologies. Recent advancements in positive psychology research highlight its applicability across various professional domains and healthcare sector is not an exception.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6a1a563c5940cb5b2e95313c49192b58" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111672546,"asset_id":110598756,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111672546/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110598756"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110598756"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110598756; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110598756]").text(description); $(".js-view-count[data-work-id=110598756]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110598756; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110598756']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110598756, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6a1a563c5940cb5b2e95313c49192b58" } } $('.js-work-strip[data-work-id=110598756]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110598756,"title":"Optimizing Healthcare Project Management with Positive Psychology","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685707","issue":"2","volume":"1","abstract":"As healthcare organizations navigate the complexities of the industry, project managers play a central role in optimizing patient care and operational processes. In such dynamic setting, positive psychology emerges as a paradigm, offering a holistic framework that extends beyond traditional project management methodologies. Recent advancements in positive psychology research highlight its applicability across various professional domains and healthcare sector is not an exception.","page_numbers":"1-6","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"As healthcare organizations navigate the complexities of the industry, project managers play a central role in optimizing patient care and operational processes. In such dynamic setting, positive psychology emerges as a paradigm, offering a holistic framework that extends beyond traditional project management methodologies. Recent advancements in positive psychology research highlight its applicability across various professional domains and healthcare sector is not an exception.","internal_url":"https://www.academia.edu/110598756/Optimizing_Healthcare_Project_Management_with_Positive_Psychology","translated_internal_url":"","created_at":"2023-12-04T23:03:38.348-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40647630,"work_id":110598756,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":1,"name":"Shohreh Majd","title":"Optimizing Healthcare Project Management with Positive Psychology"},{"id":40647631,"work_id":110598756,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":7938022,"email":"d***d@gmx.net","display_order":2,"name":"Zohreh Majd","title":"Optimizing Healthcare Project Management with Positive Psychology"}],"downloadable_attachments":[{"id":111672546,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111672546/thumbnails/1.jpg","file_name":"1_Optimizing_Healthcare_Project_Management.pdf","download_url":"https://www.academia.edu/attachments/111672546/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Optimizing_Healthcare_Project_Management.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111672546/1_Optimizing_Healthcare_Project_Management-libre.pdf?1708484709=\u0026response-content-disposition=attachment%3B+filename%3DOptimizing_Healthcare_Project_Management.pdf\u0026Expires=1732758177\u0026Signature=AjZzjjZRqpsSqVlhfgF4DWrGSjdlkROsuKNdluBPvgGu6b0oFG-ZPYpa5bof17WkEh1rGWxoVlfoyBXvywECvlTR1qoyD6wk5AP8zXuaa2PPuYppxE417Qe0W1CqG2~PdlbyIAVRie1ibC8hm7YJGW1KeoB5l9uVPYDcTqimcaiA58o~tIuwLVqKrWA4FBJmNnvGOnziKTckPeCxcfPbgw9QvpuPOsb7DMY3cAH7FrEKGp3VCGrQ56z33l3hIsvWRNkyZ6vnPIVCABP1DcWGSB7RUYlgXy8LXTCYyawbTwsDk01lYIEmdx0YUw1IvCBfA8X9sEI6g~kUoaGJRpUL2Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Optimizing_Healthcare_Project_Management_with_Positive_Psychology","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111672546,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111672546/thumbnails/1.jpg","file_name":"1_Optimizing_Healthcare_Project_Management.pdf","download_url":"https://www.academia.edu/attachments/111672546/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Optimizing_Healthcare_Project_Management.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111672546/1_Optimizing_Healthcare_Project_Management-libre.pdf?1708484709=\u0026response-content-disposition=attachment%3B+filename%3DOptimizing_Healthcare_Project_Management.pdf\u0026Expires=1732758177\u0026Signature=AjZzjjZRqpsSqVlhfgF4DWrGSjdlkROsuKNdluBPvgGu6b0oFG-ZPYpa5bof17WkEh1rGWxoVlfoyBXvywECvlTR1qoyD6wk5AP8zXuaa2PPuYppxE417Qe0W1CqG2~PdlbyIAVRie1ibC8hm7YJGW1KeoB5l9uVPYDcTqimcaiA58o~tIuwLVqKrWA4FBJmNnvGOnziKTckPeCxcfPbgw9QvpuPOsb7DMY3cAH7FrEKGp3VCGrQ56z33l3hIsvWRNkyZ6vnPIVCABP1DcWGSB7RUYlgXy8LXTCYyawbTwsDk01lYIEmdx0YUw1IvCBfA8X9sEI6g~kUoaGJRpUL2Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":90896,"name":"Healthcare Management","url":"https://www.academia.edu/Documents/in/Healthcare_Management"}],"urls":[{"id":39651546,"url":"https://integratedrhd.com/2023-12-p1-6/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110595285"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110595285/Traumatic_Brain_Injury_and_its_Link_to_Alzheimers_Disease"><img alt="Research paper thumbnail of Traumatic Brain Injury and its Link to Alzheimer's Disease" class="work-thumbnail" src="https://attachments.academia-assets.com/111673940/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110595285/Traumatic_Brain_Injury_and_its_Link_to_Alzheimers_Disease">Traumatic Brain Injury and its Link to Alzheimer's Disease</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The intricate relationship between traumatic brain injury (TBI) and Alzheimer's disease (AD) is a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The intricate relationship between traumatic brain injury (TBI) and Alzheimer's disease (AD) is a focal point of neuroscientific inquiry. Growing evidence suggests that individuals with a history of TBI may face an elevated risk of developing memory loss later in life, including a persistent pattern connecting moderate and severe TBI with an elevated vulnerability to Alzheimer's disease and related dementias. This revelation raises significant public health concerns, prompting an in-depth exploration with a focus shift to the intricate interplay between TBI and alterations in both brain structure and function. <br />Of particular interest are the roles played by beta amyloid (Aβ) and tau protein, two molecular protagonists implicated in the trajectory from TBI to Alzheimer's pathology. Unravelling these intricacies not only elucidates the link between TBI and neurodegenerative disorders but also illuminates potential avenues for preventive interventions against Alzheimer's disease. This article contributes to a nuanced understanding of the profound consequences of TBI, offering insights that inform public health initiatives and clinical strategies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="09590ac663ae96d068ac6fe5b001f658" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111673940,"asset_id":110595285,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111673940/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110595285"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110595285"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110595285; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110595285]").text(description); $(".js-view-count[data-work-id=110595285]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110595285; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110595285']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110595285, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "09590ac663ae96d068ac6fe5b001f658" } } $('.js-work-strip[data-work-id=110595285]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110595285,"title":"Traumatic Brain Injury and its Link to Alzheimer's Disease","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685840","issue":"2","volume":"1","abstract":"The intricate relationship between traumatic brain injury (TBI) and Alzheimer's disease (AD) is a focal point of neuroscientific inquiry. Growing evidence suggests that individuals with a history of TBI may face an elevated risk of developing memory loss later in life, including a persistent pattern connecting moderate and severe TBI with an elevated vulnerability to Alzheimer's disease and related dementias. This revelation raises significant public health concerns, prompting an in-depth exploration with a focus shift to the intricate interplay between TBI and alterations in both brain structure and function. \nOf particular interest are the roles played by beta amyloid (Aβ) and tau protein, two molecular protagonists implicated in the trajectory from TBI to Alzheimer's pathology. Unravelling these intricacies not only elucidates the link between TBI and neurodegenerative disorders but also illuminates potential avenues for preventive interventions against Alzheimer's disease. This article contributes to a nuanced understanding of the profound consequences of TBI, offering insights that inform public health initiatives and clinical strategies.\n","page_numbers":"20-26","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"The intricate relationship between traumatic brain injury (TBI) and Alzheimer's disease (AD) is a focal point of neuroscientific inquiry. Growing evidence suggests that individuals with a history of TBI may face an elevated risk of developing memory loss later in life, including a persistent pattern connecting moderate and severe TBI with an elevated vulnerability to Alzheimer's disease and related dementias. This revelation raises significant public health concerns, prompting an in-depth exploration with a focus shift to the intricate interplay between TBI and alterations in both brain structure and function. \nOf particular interest are the roles played by beta amyloid (Aβ) and tau protein, two molecular protagonists implicated in the trajectory from TBI to Alzheimer's pathology. Unravelling these intricacies not only elucidates the link between TBI and neurodegenerative disorders but also illuminates potential avenues for preventive interventions against Alzheimer's disease. This article contributes to a nuanced understanding of the profound consequences of TBI, offering insights that inform public health initiatives and clinical strategies.\n","internal_url":"https://www.academia.edu/110595285/Traumatic_Brain_Injury_and_its_Link_to_Alzheimers_Disease","translated_internal_url":"","created_at":"2023-12-04T22:10:11.505-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40647400,"work_id":110595285,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":1,"name":"Shohreh Majd","title":"Traumatic Brain Injury and its Link to Alzheimer's Disease"}],"downloadable_attachments":[{"id":111673940,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111673940/thumbnails/1.jpg","file_name":"4_Traumatic_Brain_Injury_and_its_Link_to_Alzheimer_s_Disease.pdf","download_url":"https://www.academia.edu/attachments/111673940/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Traumatic_Brain_Injury_and_its_Link_to_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111673940/4_Traumatic_Brain_Injury_and_its_Link_to_Alzheimer_s_Disease-libre.pdf?1708492664=\u0026response-content-disposition=attachment%3B+filename%3DTraumatic_Brain_Injury_and_its_Link_to_A.pdf\u0026Expires=1732758177\u0026Signature=QzQv4sHXvFKh4kl7BBbCt00GNqyCmDHyZUNDo94002dLxLi7D6JNGTu7q8Ch6QfA4jADR~cz3OlXW3qdbBi5bKdWIChZMgQ4000xzE~kUzujuYVhqOhrBDgTgSy7f1aZWshklPEntbgvt4JLJDUPG9IBaQfE6Nrhgr5WIomPJ3aNWfmekYPRENo31RtQxtIKyEDc1-Zhy1xwopKZMwxGYMWYqIQKgUrwLrcIldvmUSxIX1QcyT1TTeMD-c8ItHnBdAJ0jJ6UL655uwJj~Bmsa7scD95b8ng-39ha0Ci~~qAknctT4IxxgOfbt3SH2AWjBK95RgrCCxliiTsqt0iMGg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Traumatic_Brain_Injury_and_its_Link_to_Alzheimers_Disease","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111673940,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111673940/thumbnails/1.jpg","file_name":"4_Traumatic_Brain_Injury_and_its_Link_to_Alzheimer_s_Disease.pdf","download_url":"https://www.academia.edu/attachments/111673940/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Traumatic_Brain_Injury_and_its_Link_to_A.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111673940/4_Traumatic_Brain_Injury_and_its_Link_to_Alzheimer_s_Disease-libre.pdf?1708492664=\u0026response-content-disposition=attachment%3B+filename%3DTraumatic_Brain_Injury_and_its_Link_to_A.pdf\u0026Expires=1732758177\u0026Signature=QzQv4sHXvFKh4kl7BBbCt00GNqyCmDHyZUNDo94002dLxLi7D6JNGTu7q8Ch6QfA4jADR~cz3OlXW3qdbBi5bKdWIChZMgQ4000xzE~kUzujuYVhqOhrBDgTgSy7f1aZWshklPEntbgvt4JLJDUPG9IBaQfE6Nrhgr5WIomPJ3aNWfmekYPRENo31RtQxtIKyEDc1-Zhy1xwopKZMwxGYMWYqIQKgUrwLrcIldvmUSxIX1QcyT1TTeMD-c8ItHnBdAJ0jJ6UL655uwJj~Bmsa7scD95b8ng-39ha0Ci~~qAknctT4IxxgOfbt3SH2AWjBK95RgrCCxliiTsqt0iMGg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3720,"name":"Traumatic Brain Injury","url":"https://www.academia.edu/Documents/in/Traumatic_Brain_Injury"},{"id":3776,"name":"Alzheimer's Disease","url":"https://www.academia.edu/Documents/in/Alzheimers_Disease"},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":162164,"name":"Beta Amyloid","url":"https://www.academia.edu/Documents/in/Beta_Amyloid"},{"id":245743,"name":"Tau Protein; Microtubules; Microtubule Dynamics","url":"https://www.academia.edu/Documents/in/Tau_Protein_Microtubules_Microtubule_Dynamics"}],"urls":[{"id":39652986,"url":"https://integratedrhd.com/2023-12-p20-26/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110592909"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110592909/Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research"><img alt="Research paper thumbnail of Tumour Microenvironment: Pivotal Players, Therapeutic Strategies, and Ongoing Frontiers in Cancer Research" class="work-thumbnail" src="https://attachments.academia-assets.com/111672904/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110592909/Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research">Tumour Microenvironment: Pivotal Players, Therapeutic Strategies, and Ongoing Frontiers in Cancer Research</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cancer progression hinges on the intricate interplay between cancer cells and the tumour microenv...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cancer progression hinges on the intricate interplay between cancer cells and the tumour microenvironment (TME), where Cancer-Associated Fibroblasts (CAFs) play a pivotal role in creating a supportive milieu. Targeting CAFs and stromal components stands as an innovative therapeutic strategy with the potential to impede tumour progression. Simultaneously, immunotherapy, particularly immune checkpoint inhibitors, revolutionizes cancer treatment by unleashing potent anti-tumour immune responses. Ongoing research into novel immune checkpoint targets and combination strategies enhances the dynamic nature of immunotherapy. Molecular signalling pathways like Transforming Growth Factor-beta (TGF-β) and Hypoxia-Inducible Factor (HIF) provide intricate insights into TME crosstalk. Dysregulation of TGF-β signalling is associated with poor prognosis, highlighting its therapeutic potential. The dynamic reciprocity between cancer cells and the Extracellular Matrix (ECM) significantly influences cancer behaviour. While substantial strides have been made, ongoing research is imperative to unravel the full complexities of the TME. This exploration serves as the foundation for personalized and targeted therapeutic strategies, combining stromal-targeted therapies, immunotherapy advancements, and insights into molecular signalling pathways. This review navigates the multifaceted ways the TME influences cancer progression, offering a comprehensive understanding that propels innovative therapeutic interventions. Ultimately, this signifies the relentless pursuit of effective cancer treatments, fostering hope and a promising era in the fight against cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9614d2c4afeafaaf406ba2b2af2e9053" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111672904,"asset_id":110592909,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111672904/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110592909"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110592909"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110592909; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110592909]").text(description); $(".js-view-count[data-work-id=110592909]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110592909; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110592909']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110592909, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9614d2c4afeafaaf406ba2b2af2e9053" } } $('.js-work-strip[data-work-id=110592909]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110592909,"title":"Tumour Microenvironment: Pivotal Players, Therapeutic Strategies, and Ongoing Frontiers in Cancer Research","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685757","abstract":"Cancer progression hinges on the intricate interplay between cancer cells and the tumour microenvironment (TME), where Cancer-Associated Fibroblasts (CAFs) play a pivotal role in creating a supportive milieu. Targeting CAFs and stromal components stands as an innovative therapeutic strategy with the potential to impede tumour progression. Simultaneously, immunotherapy, particularly immune checkpoint inhibitors, revolutionizes cancer treatment by unleashing potent anti-tumour immune responses. Ongoing research into novel immune checkpoint targets and combination strategies enhances the dynamic nature of immunotherapy. Molecular signalling pathways like Transforming Growth Factor-beta (TGF-β) and Hypoxia-Inducible Factor (HIF) provide intricate insights into TME crosstalk. Dysregulation of TGF-β signalling is associated with poor prognosis, highlighting its therapeutic potential. The dynamic reciprocity between cancer cells and the Extracellular Matrix (ECM) significantly influences cancer behaviour. While substantial strides have been made, ongoing research is imperative to unravel the full complexities of the TME. This exploration serves as the foundation for personalized and targeted therapeutic strategies, combining stromal-targeted therapies, immunotherapy advancements, and insights into molecular signalling pathways. This review navigates the multifaceted ways the TME influences cancer progression, offering a comprehensive understanding that propels innovative therapeutic interventions. Ultimately, this signifies the relentless pursuit of effective cancer treatments, fostering hope and a promising era in the fight against cancer.","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"Cancer progression hinges on the intricate interplay between cancer cells and the tumour microenvironment (TME), where Cancer-Associated Fibroblasts (CAFs) play a pivotal role in creating a supportive milieu. Targeting CAFs and stromal components stands as an innovative therapeutic strategy with the potential to impede tumour progression. Simultaneously, immunotherapy, particularly immune checkpoint inhibitors, revolutionizes cancer treatment by unleashing potent anti-tumour immune responses. Ongoing research into novel immune checkpoint targets and combination strategies enhances the dynamic nature of immunotherapy. Molecular signalling pathways like Transforming Growth Factor-beta (TGF-β) and Hypoxia-Inducible Factor (HIF) provide intricate insights into TME crosstalk. Dysregulation of TGF-β signalling is associated with poor prognosis, highlighting its therapeutic potential. The dynamic reciprocity between cancer cells and the Extracellular Matrix (ECM) significantly influences cancer behaviour. While substantial strides have been made, ongoing research is imperative to unravel the full complexities of the TME. This exploration serves as the foundation for personalized and targeted therapeutic strategies, combining stromal-targeted therapies, immunotherapy advancements, and insights into molecular signalling pathways. This review navigates the multifaceted ways the TME influences cancer progression, offering a comprehensive understanding that propels innovative therapeutic interventions. Ultimately, this signifies the relentless pursuit of effective cancer treatments, fostering hope and a promising era in the fight against cancer.","internal_url":"https://www.academia.edu/110592909/Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research","translated_internal_url":"","created_at":"2023-12-04T21:27:54.410-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40647035,"work_id":110592909,"tagging_user_id":282244998,"tagged_user_id":284600480,"co_author_invite_id":null,"email":"s***d@flinders.edu.au","display_order":1,"name":"Shohreh Majd","title":"Tumour Microenvironment: Pivotal Players, Therapeutic Strategies, and Ongoing Frontiers in Cancer Research"},{"id":40647036,"work_id":110592909,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":7976542,"email":"r***z@proton.me","display_order":5,"name":"Perez M","title":"Tumour Microenvironment: Pivotal Players, Therapeutic Strategies, and Ongoing Frontiers in Cancer Research"}],"downloadable_attachments":[{"id":111672904,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111672904/thumbnails/1.jpg","file_name":"3_Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research.pdf","download_url":"https://www.academia.edu/attachments/111672904/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tumour_Microenvironment_Pivotal_Players.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111672904/3_Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research-libre.pdf?1708510441=\u0026response-content-disposition=attachment%3B+filename%3DTumour_Microenvironment_Pivotal_Players.pdf\u0026Expires=1732758177\u0026Signature=VWsJaHKaErLhpRL0WoYUi8LoakGLQ-mjMrAW2BSw8MS-BX3nwRPlTqQT0YUfW6ZIE6aVrkZXvJ3XGfvFH5wWgAFog6tH4BLdPxqhxpU0d9pdbKGMaFLBhSEJeEGugQyUbMiH-cJU50OREvLkkKFj1gtYz6aH9NA4w9tTATkI7Y3IRGAEtnsI~IXPkF5-ryrb3j1ubAX-NtvvPDvul0WF-B8lKgFvNtcPXwqeFz5BHimDMf8gG-EQskKHlN~EuWfguBm-aYEaMS~8pGWw30SyYIh8J5r1wYiMZt7yw1gr-03uEHkwxG7QqcDAR~JHaDstzMtcyfBv9lcPs1KQC9LH5Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111672904,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111672904/thumbnails/1.jpg","file_name":"3_Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research.pdf","download_url":"https://www.academia.edu/attachments/111672904/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Tumour_Microenvironment_Pivotal_Players.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111672904/3_Tumour_Microenvironment_Pivotal_Players_Therapeutic_Strategies_and_Ongoing_Frontiers_in_Cancer_Research-libre.pdf?1708510441=\u0026response-content-disposition=attachment%3B+filename%3DTumour_Microenvironment_Pivotal_Players.pdf\u0026Expires=1732758177\u0026Signature=VWsJaHKaErLhpRL0WoYUi8LoakGLQ-mjMrAW2BSw8MS-BX3nwRPlTqQT0YUfW6ZIE6aVrkZXvJ3XGfvFH5wWgAFog6tH4BLdPxqhxpU0d9pdbKGMaFLBhSEJeEGugQyUbMiH-cJU50OREvLkkKFj1gtYz6aH9NA4w9tTATkI7Y3IRGAEtnsI~IXPkF5-ryrb3j1ubAX-NtvvPDvul0WF-B8lKgFvNtcPXwqeFz5BHimDMf8gG-EQskKHlN~EuWfguBm-aYEaMS~8pGWw30SyYIh8J5r1wYiMZt7yw1gr-03uEHkwxG7QqcDAR~JHaDstzMtcyfBv9lcPs1KQC9LH5Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":14195,"name":"Cancer Biology","url":"https://www.academia.edu/Documents/in/Cancer_Biology"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":29149,"name":"Extracellular Matrix","url":"https://www.academia.edu/Documents/in/Extracellular_Matrix"},{"id":78754,"name":"Cancer Therapy","url":"https://www.academia.edu/Documents/in/Cancer_Therapy"},{"id":256053,"name":"Tumour microenvironment","url":"https://www.academia.edu/Documents/in/Tumour_microenvironment"},{"id":1961441,"name":"Signalling Pathways","url":"https://www.academia.edu/Documents/in/Signalling_Pathways"}],"urls":[{"id":36463736,"url":"https://integratedrhd.com/2023-12-p13-19/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110497045"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110497045/Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage"><img alt="Research paper thumbnail of Advances in Understanding and Managing Postpartum Hemorrhage" class="work-thumbnail" src="https://attachments.academia-assets.com/111672707/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110497045/Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage">Advances in Understanding and Managing Postpartum Hemorrhage</a></div><div class="wp-workCard_item"><span>Integrated Research in Health and Disease</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Postpartum hemorrhage (PPH), characterized by excessive bleeding within 24 hours of childbirth, p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Postpartum hemorrhage (PPH), characterized by excessive bleeding within 24 hours of childbirth, poses a significant global challenge in maternal healthcare, contributing substantially to mortality and morbidity, especially in low-income countries. The timely recognition of clinical manifestations, such as persistent bleeding and organ dysfunction are critical for effective intervention. This requires a comprehensive approach and management strategies such as pharmacological, surgical, and interventional techniques. Here we explore the multifactorial etiology of PPH, including uterine atony, genital tract trauma, retained placental tissue, and coagulopathies and examine the latest findings in the area of PPH management towards reducing mortality and morbidity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eb75a8bdf43946b56332b5a27c548f15" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":111672707,"asset_id":110497045,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/111672707/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110497045"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110497045"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110497045; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110497045]").text(description); $(".js-view-count[data-work-id=110497045]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110497045; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110497045']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110497045, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "eb75a8bdf43946b56332b5a27c548f15" } } $('.js-work-strip[data-work-id=110497045]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110497045,"title":"Advances in Understanding and Managing Postpartum Hemorrhage","translated_title":"","metadata":{"doi":"10.5281/zenodo.10685736","issue":"2","volume":"1","abstract":"Postpartum hemorrhage (PPH), characterized by excessive bleeding within 24 hours of childbirth, poses a significant global challenge in maternal healthcare, contributing substantially to mortality and morbidity, especially in low-income countries. The timely recognition of clinical manifestations, such as persistent bleeding and organ dysfunction are critical for effective intervention. This requires a comprehensive approach and management strategies such as pharmacological, surgical, and interventional techniques. Here we explore the multifactorial etiology of PPH, including uterine atony, genital tract trauma, retained placental tissue, and coagulopathies and examine the latest findings in the area of PPH management towards reducing mortality and morbidity.","page_numbers":"7-12","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Integrated Research in Health and Disease"},"translated_abstract":"Postpartum hemorrhage (PPH), characterized by excessive bleeding within 24 hours of childbirth, poses a significant global challenge in maternal healthcare, contributing substantially to mortality and morbidity, especially in low-income countries. The timely recognition of clinical manifestations, such as persistent bleeding and organ dysfunction are critical for effective intervention. This requires a comprehensive approach and management strategies such as pharmacological, surgical, and interventional techniques. Here we explore the multifactorial etiology of PPH, including uterine atony, genital tract trauma, retained placental tissue, and coagulopathies and examine the latest findings in the area of PPH management towards reducing mortality and morbidity.","internal_url":"https://www.academia.edu/110497045/Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage","translated_internal_url":"","created_at":"2023-12-03T22:07:00.474-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":40638704,"work_id":110497045,"tagging_user_id":282244998,"tagged_user_id":null,"co_author_invite_id":7974923,"email":"i***z@aol.com","display_order":4,"name":"Isabella Alvarez","title":"Advances in Understanding and Managing Postpartum Hemorrhage"}],"downloadable_attachments":[{"id":111672707,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111672707/thumbnails/1.jpg","file_name":"2_Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage_.pdf","download_url":"https://www.academia.edu/attachments/111672707/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Advances_in_Understanding_and_Managing_P.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111672707/2_Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage_-libre.pdf?1708514403=\u0026response-content-disposition=attachment%3B+filename%3DAdvances_in_Understanding_and_Managing_P.pdf\u0026Expires=1732758177\u0026Signature=K1nwgQ05AeCnUNQvLy-S0~IPRPyeRscB-AUOfpA~Pnvc7c4fi51p-UAIhrutB7QHyQLBTig8fWsYp06fPczBbJqsQZobc61xeKr7ztrAZxgGyE6nW-9~KUODQHO0YEQ7SQEjafPCOn8IpjS4ZWHdCiv2GgmuKYf8DibXcO87GMbDfygZbHypEVD1THHHyJ87xbcRkA28zWFhxL4ig92IH2Q1Wkc9x2cwAkmoXu1bBHYbAZFVwk2ZgNTK2cbYmpYIxO893dqv-wDstv2D82RKTIaLaW98N~QhWSyfQJmpDJiq3uWMSLMAB169vD~6p5OGod4WL04--jUYtSelFj8i9Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":111672707,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/111672707/thumbnails/1.jpg","file_name":"2_Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage_.pdf","download_url":"https://www.academia.edu/attachments/111672707/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Advances_in_Understanding_and_Managing_P.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/111672707/2_Advances_in_Understanding_and_Managing_Postpartum_Hemorrhage_-libre.pdf?1708514403=\u0026response-content-disposition=attachment%3B+filename%3DAdvances_in_Understanding_and_Managing_P.pdf\u0026Expires=1732758177\u0026Signature=K1nwgQ05AeCnUNQvLy-S0~IPRPyeRscB-AUOfpA~Pnvc7c4fi51p-UAIhrutB7QHyQLBTig8fWsYp06fPczBbJqsQZobc61xeKr7ztrAZxgGyE6nW-9~KUODQHO0YEQ7SQEjafPCOn8IpjS4ZWHdCiv2GgmuKYf8DibXcO87GMbDfygZbHypEVD1THHHyJ87xbcRkA28zWFhxL4ig92IH2Q1Wkc9x2cwAkmoXu1bBHYbAZFVwk2ZgNTK2cbYmpYIxO893dqv-wDstv2D82RKTIaLaW98N~QhWSyfQJmpDJiq3uWMSLMAB169vD~6p5OGod4WL04--jUYtSelFj8i9Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":103289,"name":"Gynecology and Obstetrics","url":"https://www.academia.edu/Documents/in/Gynecology_and_Obstetrics"},{"id":163604,"name":"Nursing and midwifery","url":"https://www.academia.edu/Documents/in/Nursing_and_midwifery"}],"urls":[{"id":39651702,"url":"https://integratedrhd.com/2023-12-p1-7-12/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110442257"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110442257/Beta_estradiol_and_norepinephrine_treatment_of_differentiated_SH_SY5Y_cells_enhances_tau_phosphorylation_at_Ser396_and_Ser262_via_AMPK_but_not_mTOR_signaling_pathway"><img alt="Research paper thumbnail of Beta estradiol and norepinephrine treatment of differentiated SH-SY5Y cells enhances tau phosphorylation at (Ser396) and (Ser262) via AMPK but not mTOR signaling pathway" class="work-thumbnail" src="https://attachments.academia-assets.com/108258639/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110442257/Beta_estradiol_and_norepinephrine_treatment_of_differentiated_SH_SY5Y_cells_enhances_tau_phosphorylation_at_Ser396_and_Ser262_via_AMPK_but_not_mTOR_signaling_pathway">Beta estradiol and norepinephrine treatment of differentiated SH-SY5Y cells enhances tau phosphorylation at (Ser396) and (Ser262) via AMPK but not mTOR signaling pathway</a></div><div class="wp-workCard_item"><span>Molecular and Cellular Neuroscience</span><span>, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e8a47e00eb86efd9839df7f735e895ee" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108258639,"asset_id":110442257,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108258639/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110442257"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110442257"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110442257; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110442257]").text(description); $(".js-view-count[data-work-id=110442257]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110442257; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110442257']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 110442257, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e8a47e00eb86efd9839df7f735e895ee" } } $('.js-work-strip[data-work-id=110442257]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110442257,"title":"Beta estradiol and norepinephrine treatment of differentiated SH-SY5Y cells enhances tau phosphorylation at (Ser396) and (Ser262) via AMPK but not mTOR signaling pathway","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Beta estradiol and norepinephrine treatment of differentiated SH-SY5Y cells enhances tau phosphorylation at (Ser396) and (Ser262) via AMPK but not mTOR signaling pathway.","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Molecular and Cellular Neuroscience","grobid_abstract_attachment_id":108258639},"translated_abstract":null,"internal_url":"https://www.academia.edu/110442257/Beta_estradiol_and_norepinephrine_treatment_of_differentiated_SH_SY5Y_cells_enhances_tau_phosphorylation_at_Ser396_and_Ser262_via_AMPK_but_not_mTOR_signaling_pathway","translated_internal_url":"","created_at":"2023-12-03T05:55:28.089-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":282244998,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":108258639,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108258639/thumbnails/1.jpg","file_name":"Majd_Beta_AM2018.pdf","download_url":"https://www.academia.edu/attachments/108258639/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Beta_estradiol_and_norepinephrine_treatm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108258639/Majd_Beta_AM2018-libre.pdf?1701614612=\u0026response-content-disposition=attachment%3B+filename%3DBeta_estradiol_and_norepinephrine_treatm.pdf\u0026Expires=1732758177\u0026Signature=DqAsfxtdRgM8kcyBsCHnyuvUvg5VotNduHwKUgj5nQtVN42xbH0pnPrXJz9LKDfgkgD0GtUgtNYmfD9tfoBO4vxFn3hx6V6xsbSWWMx6sHzbyXq5c9HOVpATuTs7tCNp827toOrxhgBxfA76UyWFBKdorj7dIq~PL7B~A~EwISEzJUz81GuG5WzCbDcCmAcyamWlD4sik3wH-GugL8MPGT0c--m~TZqjEXZKMCSClBPU4XwndUGLBHZBJEWRtIOZ5N1SqGfEgkQ8T3rKOjTW7ukbCWWLUmutYCgzySGkqHLlrR54QjaVURDrJFCI76EFLXYYegrWjMmESE2U2zVHkg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Beta_estradiol_and_norepinephrine_treatment_of_differentiated_SH_SY5Y_cells_enhances_tau_phosphorylation_at_Ser396_and_Ser262_via_AMPK_but_not_mTOR_signaling_pathway","translated_slug":"","page_count":33,"language":"en","content_type":"Work","owner":{"id":282244998,"first_name":"IRHD","middle_initials":null,"last_name":"Journal","page_name":"IRHDJournal","domain_name":"independent","created_at":"2023-09-03T03:40:36.363-07:00","display_name":"IRHD Journal","url":"https://independent.academia.edu/IRHDJournal"},"attachments":[{"id":108258639,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108258639/thumbnails/1.jpg","file_name":"Majd_Beta_AM2018.pdf","download_url":"https://www.academia.edu/attachments/108258639/download_file?st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NDU3Nyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Beta_estradiol_and_norepinephrine_treatm.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108258639/Majd_Beta_AM2018-libre.pdf?1701614612=\u0026response-content-disposition=attachment%3B+filename%3DBeta_estradiol_and_norepinephrine_treatm.pdf\u0026Expires=1732758177\u0026Signature=DqAsfxtdRgM8kcyBsCHnyuvUvg5VotNduHwKUgj5nQtVN42xbH0pnPrXJz9LKDfgkgD0GtUgtNYmfD9tfoBO4vxFn3hx6V6xsbSWWMx6sHzbyXq5c9HOVpATuTs7tCNp827toOrxhgBxfA76UyWFBKdorj7dIq~PL7B~A~EwISEzJUz81GuG5WzCbDcCmAcyamWlD4sik3wH-GugL8MPGT0c--m~TZqjEXZKMCSClBPU4XwndUGLBHZBJEWRtIOZ5N1SqGfEgkQ8T3rKOjTW7ukbCWWLUmutYCgzySGkqHLlrR54QjaVURDrJFCI76EFLXYYegrWjMmESE2U2zVHkg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":172084,"name":"AMPK","url":"https://www.academia.edu/Documents/in/AMPK"},{"id":223869,"name":"Protein Phosphatase 2A","url":"https://www.academia.edu/Documents/in/Protein_Phosphatase_2A"},{"id":235189,"name":"Norepinephrine","url":"https://www.academia.edu/Documents/in/Norepinephrine"},{"id":364836,"name":"Rapamycin","url":"https://www.academia.edu/Documents/in/Rapamycin"},{"id":594811,"name":"Cellular and Molecular Neuroscience","url":"https://www.academia.edu/Documents/in/Cellular_and_Molecular_Neuroscience"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":36347158,"url":"https://api.elsevier.com/content/article/PII:S1044743117302397?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "7fc92ac00fb8df049d99c97ac4bd25bde2588c8d32d8d70ac097c107eab19931", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="oa2GkLz6SfIZAzaCPZNt8eLJRtx3dx7AgwuoarfhlRZ2S9Kof8PfmWe1zsA/biMJtupEnWGxplrFn2iYx1PFBg==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://independent.academia.edu/IRHDJournal" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="myamkii6oy9W8OKxCi1D36v6z/fZoSym1T2TUeoVsPJMwPKq64M1RChGGvMI0A0n/9nNts9nlDyTqVOjmqfg4g==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>