Picture Perfect: Researchers Gain Clearest Ever Image of Ebola Virus Protein | Okinawa Institute of Science and Technology OIST

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</li> <li class="menu-item flex flex-col my-2.5 px-2.5"> <a href="/outreach/community/spotlight" class="menu-sub-item py-2 block ">OISTer Spotlight</a> </li> </ul> </li> <li class="menu-item flex flex-col my-2.5 px-2.5"> <a href="/sdg" class="menu-sub-item py-2 block ">SDGs</a> </li> </ul> </li> <li class="menu-item flex flex-col"> <button href="" class="menu-root-item block text-2xl leading-11 font-header w-full text-left ">Campus</button> <ul class="sub-menu text-lg font-bold"> <li class="menu-item flex flex-col my-2.5 px-2.5"> <button class="menu-sub-item flex items-center py-2 text-left ">Campus <span class="expand-indicator flex justify-center items-center w-6 h-6 border-2 rounded-full border-white ml-4 "></span></button> <ul class="sub-menu text-lg font-normal"> <li class="menu-item flex flex-col my-2.5 px-2.5"> <a href="/campus" class="menu-sub-item py-2 block ">Campus</a> </li> <li class="menu-item flex flex-col my-2.5 px-2.5"> <a href="/clinic" class="menu-sub-item py-2 block 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class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">About OIST</a> </li> <li> <a data-menu-child="" href="/about/facts-and-figures" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Facts and Figures</a> </li> <li> <button data-menu-child="1f99cb1d-b07f-472c-9df6-d0d477f0f2e8" class="menu-sub-item flex items-center py-2 lg:py-0 lg:whitespace-nowrap text-left ">President <span class="expand-indicator flex justify-center items-center w-6 h-6 border-2 rounded-full border-white ml-4 "></span></button> </li> <li> <button data-menu-child="c27fa62a-366a-44e1-9eeb-39ba5e751ed5" class="menu-sub-item flex items-center py-2 lg:py-0 lg:whitespace-nowrap text-left ">Leadership and Governance <span class="expand-indicator flex justify-center items-center w-6 h-6 border-2 rounded-full border-white ml-4 "></span></button> </li> <li> <button data-menu-child="3d20caf0-8528-4220-b55e-aae0659a6b45" class="menu-sub-item flex items-center py-2 lg:py-0 lg:whitespace-nowrap text-left 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border-white ml-4 "></span></button> </li> <li> <a data-menu-child="" href="https://groups.oist.jp/ja/coo/information-disclosure" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Information Disclosure</a> </li> </ul> </div> <div data-menu-level="1" id="cf5be12c-d9c1-4693-8c42-e1fcdab211a2" class="menu sub-menu"> <ul class="font-bold text-lg lg:flex-col lg:space-y-3 lg:text-xl lg:ml-12 lg:px-2.5"> <li> <a data-menu-child="" href="/research" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Research</a> </li> <li> <a data-menu-child="" href="/research/research-units" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Research Units</a> </li> <li> <a data-menu-child="" href="/research/faculty-members" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Faculty</a> </li> <li> <a data-menu-child="" href="/research/discover" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Research Specialties</a> </li> <li> <a 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sub-menu"> <ul class="font-bold text-lg lg:flex-col lg:space-y-3 lg:text-xl lg:ml-12 lg:px-2.5"> <li> <a data-menu-child="" href="/study" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Study</a> </li> <li> <a data-menu-child="" href="/study/phd-research-internship-program" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">PhD and Research Internship Program</a> </li> <li> <a data-menu-child="" href="/study/graduate-school-three-policies" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">The Graduate School Three Policies</a> </li> <li> <a data-menu-child="" href="/study/graduate-school-office" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Graduate School Office</a> </li> <li> <a data-menu-child="" href="/study/student-life" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Student Life</a> </li> <li> <a data-menu-child="" href="/study/library" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap 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data-menu-level="1" id="40edcacb-bfac-4667-82ec-ab46abfad443" class="menu sub-menu"> <ul class="font-bold text-lg lg:flex-col lg:space-y-3 lg:text-xl lg:ml-12 lg:px-2.5"> <li> <button data-menu-child="30a78a21-1ca3-4535-975d-09d39b2016c7" class="menu-sub-item flex items-center py-2 lg:py-0 lg:whitespace-nowrap text-left ">Campus <span class="expand-indicator flex justify-center items-center w-6 h-6 border-2 rounded-full border-white ml-4 "></span></button> </li> <li> <a data-menu-child="" href="/campus/access-map" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Access</a> </li> <li> <a data-menu-child="" href="/campus/parking" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Parking</a> </li> <li> <a data-menu-child="" href="/campus/event-venue" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Event Venues</a> </li> <li> <a data-menu-child="" href="/campus/tokyo-office" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Tokyo Office</a> </li> <li> <a data-menu-child="" href="/campus/seaside-house" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Seaside House</a> </li> <li> <a data-menu-child="" href="/campus/marine-science-station" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Marine Science Station</a> </li> </ul> </div> <div data-menu-level="1" id="5dde840c-fadc-4777-aebf-fe3b84984858" class="menu sub-menu"> <ul class="font-bold text-lg lg:flex-col lg:space-y-3 lg:text-xl lg:ml-12 lg:px-2.5"> <li> <a data-menu-child="" href="/careers" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Open Positions</a> </li> <li> <a data-menu-child="" href="/careers/faculty-positions" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Faculty Positions</a> </li> <li> <a data-menu-child="" href="/careers/background-check" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Background Check</a> </li> <li> <a data-menu-child="" href="https://groups.oist.jp/hr-relocation" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">HR Relocation</a> </li> <li> <a data-menu-child="" href="/diversity" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Diversity</a> </li> <li> <a data-menu-child="" href="/c-hub" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Professional Development & Inclusion</a> </li> </ul> </div> </div> <div class="menu_level_2 hidden lg:block menu_level_0 py-6 pr-8 overflow-auto scrollbar scrollbar-thin scrollbar-thumb-blue-gray scrollbar-rounded-full scrollbar-track-blue-dark"> <div data-menu-level="2" id="1f99cb1d-b07f-472c-9df6-d0d477f0f2e8" class="menu sub-menu"> <ul class="font-bold text-lg lg:flex-col lg:space-y-3 lg:text-xl lg:ml-12 lg:px-2.5 lg:left-full"> <li> <a data-menu-child="" href="/about/president" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">President</a> </li> <li> <a data-menu-child="" href="/about/president/media-library" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Presidential Media Library</a> </li> <li> <a data-menu-child="" href="/about/president/lectures" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Presidential Lectures</a> </li> <li> <a data-menu-child="" href="/about/president/office" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Office of the President</a> </li> <li> <a data-menu-child="" href="/about/president/university-management-forum" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">President's Council</a> </li> </ul> </div> <div data-menu-level="2" id="c27fa62a-366a-44e1-9eeb-39ba5e751ed5" class="menu sub-menu"> <ul class="font-bold text-lg lg:flex-col lg:space-y-3 lg:text-xl lg:ml-12 lg:px-2.5 lg:left-full"> <li> <a data-menu-child="" href="/about/leadership-governance" class="menu-sub-item py-2 lg:py-0 block lg:whitespace-nowrap ">Leadership and Governance</a> </li> <li> <a data-menu-child="" 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<div class="region region-content"> <div id="block-server-theme-breadcrumbs" class="block block-system block-system-breadcrumb-block"> <div class="pb-2 lg:pb-4 breadcrumbs print:hidden"> <p id="system-breadcrumb" class="visually-hidden">Breadcrumb</p> <nav class="pl-29.5 lg:pl-70 pr-4 pt-2 lg:pt-4" role="navigation" aria-labelledby="system-breadcrumb"> <div class="m-0 p-0 flex flex-row text-sm items-center text-gray-900 text-sm lg:text-lg font-body underline-links"> <div class="truncate inline"> <a href="/">Home</a> </div> </div> </nav> </div> </div> <div data-drupal-messages-fallback class="hidden"></div> <div id="block-server-theme-content" class="block block-system block-system-main-block"> <article about="/news-center/press-releases/picture-perfect-researchers-gain-clearest-ever-image-ebola-virus-protein" class="node node--type-news-article node--promoted node--view-mode-full"> <div class="node__content"> <div class="container-wide flex flex-col gap-4 mt-6 mb-8 lg:mb-10 print:!px-0 print:!mt-12"> <h1 class="page-title text-2xl md:text-5xl md:leading-16 lg:leading-tight print:!text-2xl max-w-full"> <budoux-ja>Picture Perfect: Researchers Gain Clearest Ever Image of Ebola Virus Protein</budoux-ja> </h1> <p class="text-gray-900 text-base md:text-lg lg:text-2xl"> <budoux-ja>Near-atomic resolution model of viral protein complex brings clearer understanding of the viral mechanics.</budoux-ja> </p> </div> <div class="hero relative"> <article class="media media--type-image media--view-mode-hero"> <figure class="child-object-cover block w-full bg-gray-300 hero-image"> <picture> <source srcset="/sites/default/files/styles/background_image_xl_1x/public/20181018-ebola-nucleocapsid-mattihas-wolf.png?h=14f0de79&itok=tCCEJBde 1x, /sites/default/files/styles/background_image_xl_2x/public/20181018-ebola-nucleocapsid-mattihas-wolf.png?h=14f0de79&itok=xg5PCYcd 2x" media="all and (min-width: 1536px)" type="image/png" width="1920" height="1080"/> <source srcset="/sites/default/files/styles/background_image_xl_low_1x/public/20181018-ebola-nucleocapsid-mattihas-wolf.png?h=14f0de79&itok=RCp1LVMz 1x, /sites/default/files/styles/background_image_xl_low_2x/public/20181018-ebola-nucleocapsid-mattihas-wolf.png?h=14f0de79&itok=AH4cBj_J 2x" media="all and (min-width: 1280px)" type="image/png" width="1280" height="720"/> <source srcset="/sites/default/files/styles/background_image_lg_1x/public/20181018-ebola-nucleocapsid-mattihas-wolf.png?h=14f0de79&itok=rFJVAmcJ 1x, /sites/default/files/styles/background_image_lg_2x/public/20181018-ebola-nucleocapsid-mattihas-wolf.png?h=14f0de79&itok=JI9WaTO- 2x" media="all and (min-width: 1024px)" type="image/png" width="1024" height="576"/> <source srcset="/sites/default/files/styles/background_image_md_1x/public/20181018-ebola-nucleocapsid-mattihas-wolf.png?h=14f0de79&itok=BmNUt2pe 1x, /sites/default/files/styles/background_image_md_2x/public/20181018-ebola-nucleocapsid-mattihas-wolf.png?h=14f0de79&itok=KV7Pv9TN 2x" media="all and (min-width: 768px)" type="image/png" width="768" height="432"/> <source srcset="/sites/default/files/styles/background_image_mobile_1x/public/20181018-ebola-nucleocapsid-mattihas-wolf.png?h=14f0de79&itok=YKrK04Xt 1x, /sites/default/files/styles/background_image_mobile_2x/public/20181018-ebola-nucleocapsid-mattihas-wolf.png?h=14f0de79&itok=MiTHbPar 2x" type="image/png" width="390" height="220"/> <img src="/sites/default/files/styles/background_image_xl_low_1x/public/20181018-ebola-nucleocapsid-mattihas-wolf.png?h=14f0de79&itok=RCp1LVMz" width="1280" height="720" alt="" loading="lazy" typeof="foaf:Image" /> </picture> </figure> </article> </div> <div class="body-and-sidebar container-wide py-8 lg:py-10"> <div class="font-body grid lg:flex lg:flex-row"> <div class="body-and-sidebar-body contents lg:flex lg:flex-col lg:mr-30 lg:w-full"> <div class="row-start-2 mb-8 lg:mb-0"> <div class="styled-body "> <div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="tex2jax_process"><p>Researchers at the Okinawa Institute of Science and Technology Graduate University (OIST) have for the first time imaged the structure of a central component of <a href="http://pdb101.rcsb.org/motm/178" target="_blank">the Ebola virus</a> at near-atomic resolution.</p> <p>The study, published in the journal <a href="http://dx.doi.org/10.1038/s41586-018-0630-0" target="_blank"><em>Nature</em></a>, was led by Prof. Matthias Wolf and primary author Dr. Yukihiko Sugita of OIST’s <a href="https://groups.oist.jp/mcemu" target="_blank">Molecular Cryo-Electron Microscopy Unit</a> (MCEMU) in a collaboration with world-renowned virologist Prof. Yoshihiro Kawaoka (University of Tokyo and University of Wisconsin-Madison), Prof. Takeshi Noda (Kyoto University) and structural biologist Dr. Hideyuki Matsunami (OIST).</p> <p><div data-entity-type="media" data-embed-button="media" data-entity-uuid="dc09110c-614a-4e6a-ad24-590b0fe1d229" data-entity-embed-display="view_mode:media.embed" data-entity-embed-display-settings="[]" data-langcode="en" class="embedded-entity"><article class="media media--type-image media--view-mode-embed"> <div class="mb-8 lg:mb-10"> <div class="flex justify-center "> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/sites/default/files/styles/embed_lg_1x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?itok=vI387cjX 1x, /sites/default/files/styles/embed_lg_2x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?itok=g4m2hU16 2x" media="all and (min-width: 1024px)" type="image/jpeg" width="720" height="347"> <source srcset="/sites/default/files/styles/embed_md/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?itok=lug6wVMt 1x, /sites/default/files/styles/embed_md_2x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?itok=dP8-lWbo 2x" media="all and (min-width: 768px)" type="image/jpeg" width="975" height="469"> <source srcset="/sites/default/files/styles/embed_sm_1x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?itok=TPqyJg5Y 1x, /sites/default/files/styles/embed_sm_2x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?itok=pzN-c4tF 2x" media="all and (min-width: 640px)" type="image/jpeg" width="672" height="323"> <source srcset="/sites/default/files/styles/embed_mobile_1x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?itok=PYPWVa1y 1x, /sites/default/files/styles/embed_mobile_2x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?itok=40YG2bzR 2x" type="image/jpeg" width="599" height="288"> <img src="/sites/default/files/styles/embed_lg_1x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?itok=vI387cjX" width="720" height="347" alt loading="lazy" typeof="foaf:Image"> </picture> </div> </div> <div class="media-caption text-sm text-gray-700 mt-4 flex flex-col space-y-1"> <div class="font-body leading-5 md:leading-6 mb-3">Left: Dr. Yukihiko Sugita in front of his desk at the current affiliation, Institute for Protein Research, Osaka University. Right: Prof Matthias Wolf with a Cryo-EM microscope at OIST.     </div> <div class="leading-5 md:leading-6 text-gray-500"> Yukihiko Sugita / OIST </div> </div> </div> </article> </div> </p> <p>The researchers focused on a part of the virus called the nucleocapsid (NC), a complex of proteins that acts as a support structure for the viral genetic material. This structure allows the virus to replicate its deadly payload, to devastating effect. Dr. Sugita isolated nucleoprotein-RNA complexes, which make up the core of NCs, to a high degree of purity, then analyzed them with a cryo-electron microscope (cryo-EM) to take the closest-ever look at their structure.</p> <p>“Before this study, we only knew about the smallest pieces of the NC structure,” said Dr. Sugita, “Now that we can see it as a whole, it may help find targets for antiviral drugs”.</p> <p><div data-entity-type="media" data-embed-button="media" data-entity-uuid="028beef8-99ad-44b6-b831-6f4e4ef8fd1a" data-entity-embed-display="view_mode:media.embed" data-entity-embed-display-settings="[]" data-langcode="en" class="embedded-entity"><article class="media media--type-image media--view-mode-embed"> <div class="mb-8 lg:mb-10"> <div class="flex justify-center "> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/sites/default/files/styles/embed_lg_1x/public/photos/ebola-press-release-SEM-virus.jpg?itok=b8N4pD1f 1x, /sites/default/files/styles/embed_lg_2x/public/photos/ebola-press-release-SEM-virus.jpg?itok=2BT9zhtD 2x" media="all and (min-width: 1024px)" type="image/jpeg" width="511" height="479"> <source srcset="/sites/default/files/styles/embed_md/public/photos/ebola-press-release-SEM-virus.jpg?itok=tCUP-VHM 1x, /sites/default/files/styles/embed_md_2x/public/photos/ebola-press-release-SEM-virus.jpg?itok=pEOSs17U 2x" media="all and (min-width: 768px)" type="image/jpeg" width="693" height="649"> <source srcset="/sites/default/files/styles/embed_sm_1x/public/photos/ebola-press-release-SEM-virus.jpg?itok=BgBS_C7b 1x, /sites/default/files/styles/embed_sm_2x/public/photos/ebola-press-release-SEM-virus.jpg?itok=sIz7hiKW 2x" media="all and (min-width: 640px)" type="image/jpeg" width="477" height="447"> <source srcset="/sites/default/files/styles/embed_mobile_1x/public/photos/ebola-press-release-SEM-virus.jpg?itok=q88mz4C- 1x, /sites/default/files/styles/embed_mobile_2x/public/photos/ebola-press-release-SEM-virus.jpg?itok=utEXOFi7 2x" type="image/jpeg" width="426" height="399"> <img src="/sites/default/files/styles/embed_lg_1x/public/photos/ebola-press-release-SEM-virus.jpg?itok=b8N4pD1f" width="511" height="479" alt loading="lazy" typeof="foaf:Image"> </picture> </div> </div> <div class="media-caption text-sm text-gray-700 mt-4 flex flex-col space-y-1"> <div class="font-body leading-5 md:leading-6 mb-3">Filamentous Ebola viruses budding from the surface of a host cell captured by a scanning electron microscope. In common with other viruses, Ebola virus infects a host cell and utilize its machinery to propagate.     </div> <div class="leading-5 md:leading-6 text-gray-500"> Takeshi Noda </div> </div> </div> </article> </div> </p> <p>The complete Ebola virus is a tiny invisible filamentous structure that appears like a short strand of hair when magnified thousands of times. Inside these filaments are the pieces that make up a functioning virus: NC and matrix proteins, both of which are wrapped by surface glycoproteins and a viral envelope.</p> <p><div data-entity-type="media" data-embed-button="media" data-entity-uuid="cb6109c7-a5af-4d1f-8a1c-2940cd79b28f" data-entity-embed-display="view_mode:media.embed" data-entity-embed-display-settings="[]" data-langcode="en" class="embedded-entity"><article class="media media--type-image media--view-mode-embed"> <div class="mb-8 lg:mb-10"> <div class="flex justify-center "> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/sites/default/files/styles/embed_lg_1x/public/photos/ebola-press-release-fig1_en.jpg?itok=bTYe-PMb 1x, /sites/default/files/styles/embed_lg_2x/public/photos/ebola-press-release-fig1_en.jpg?itok=G9tXhaOH 2x" media="all and (min-width: 1024px)" type="image/jpeg" width="639" height="479"> <source srcset="/sites/default/files/styles/embed_md/public/photos/ebola-press-release-fig1_en.jpg?itok=g-0GXd5F 1x, /sites/default/files/styles/embed_md_2x/public/photos/ebola-press-release-fig1_en.jpg?itok=SBGscHhj 2x" media="all and (min-width: 768px)" type="image/jpeg" width="865" height="649"> <source srcset="/sites/default/files/styles/embed_sm_1x/public/photos/ebola-press-release-fig1_en.jpg?itok=2vVtYXwm 1x, /sites/default/files/styles/embed_sm_2x/public/photos/ebola-press-release-fig1_en.jpg?itok=SpC1xxnx 2x" media="all and (min-width: 640px)" type="image/jpeg" width="596" height="447"> <source srcset="/sites/default/files/styles/embed_mobile_1x/public/photos/ebola-press-release-fig1_en.jpg?itok=tI87qzcE 1x, /sites/default/files/styles/embed_mobile_2x/public/photos/ebola-press-release-fig1_en.jpg?itok=bZsjXLm3 2x" type="image/jpeg" width="532" height="399"> <img src="/sites/default/files/styles/embed_lg_1x/public/photos/ebola-press-release-fig1_en.jpg?itok=bTYe-PMb" width="639" height="479" alt loading="lazy" typeof="foaf:Image"> </picture> </div> </div> <div class="media-caption text-sm text-gray-700 mt-4 flex flex-col space-y-1"> <div class="font-body leading-5 md:leading-6 mb-3">Left: The Ebola virus consists of the lipid bilayer (envelope), several kinds of the viral protein, and the genomic RNA. Right: The NP-RNA complex inside the virus forms a helical structure.     </div> <div class="leading-5 md:leading-6 text-gray-500"> Yukihiko Sugita </div> </div> </div> </article> </div> </p> <p>But neither the scientists at OIST nor the public were in any danger from the study: the NP-RNA complex was produced without any actual viral RNA sequence in non-infectious cells grown in the biosafety-laboratory at OIST and did not represent any risk. “It’s like the parts of a car”, said Prof. Wolf, “Unless the chassis, engine, wheels and so on are all together, nothing works. That’s what the particle we studied is like – most of its components are absent. It’s harmless”.</p> <p>Previous studies had analyzed the NC structure using a technique called electron tomography, but the cryo-EM reconstruction generated by the OIST team has much higher definition, resolving individual RNA nucleotides and amino-acid side chains. “Our paper shows for the first time what the NC structure looks like at near-atomic resolution” said Prof. Wolf.</p> <p><div data-entity-type="media" data-embed-button="media" data-entity-uuid="7ef93b10-19e2-42bf-be61-9d06a65ad5b9" data-entity-embed-display="view_mode:media.embed" data-entity-embed-display-settings="[]" data-langcode="en" class="embedded-entity"><article class="media media--type-video media--view-mode-embed"> <div class="mb-8 lg:mb-10"> <div class="flex justify-center video-wrapper"> <iframe src="/media/oembed?url=https%3A//vimeo.com/294735075&max_width=720&max_height=479&hash=-lwIzwft-DPXBCZu1N1AnamxWxLEBSJOQWK0JB0oQAc" frameborder="0" width="720" height="479" allowtransparency class="media-oembed-content vimeo-video-iframe" title="Video frame for /media/oembed?url=https%3A//vimeo.com/294735075&max_width=720&max_height=479&hash=-lwIzwft-DPXBCZu1N1AnamxWxLEBSJOQWK0JB0oQAc"></iframe> </div> <div class="media-caption text-sm text-gray-700 mt-4 flex flex-col space-y-1"> <div class="font-body leading-5 md:leading-6 mb-3">A tour of a 3D rendering and atomic model of the Ebola virus nucleocapsid core based upon the cryo-EM reconstruction created by the OIST team.       </div> <div class="leading-5 md:leading-6 text-gray-500"> Yukihiko Sugita </div> </div> </div> </article> </div> </p> <p>To get an idea of the step up the team made, imagine watching your favorite movie. If the previous study was like viewing the film on a VHS, then their novel structure is like seeing it in 4K presentation: the details are vastly sharper, with clear definition that allows scientists to get the most detailed picture yet of this component of the virus.</p> <p>It was a slow process achieving this picture, however. “The protein complexes are very fragile,” said Dr. Sugita, “getting a complete sample was very tricky”.</p> <p>Once the samples were prepared, it took the team more than 18 months to find just the right way to reconstruct the NC as a digital model. The helical structure of the protein complex is deceptively simple, but it has a fine complexity to it. Being off on the precise number and symmetry by just a few of the helix’ tiny protein building blocks can invalidate the entire model. But after systematic search, a few hints provided by another team’s publication, and new insight provided by their own high-resolution analysis, the OIST team’s hard work paid off; everything slotted into place.</p> <p><div data-entity-type="media" data-embed-button="media" data-entity-uuid="06356583-969f-4797-a2e3-cfa6c2d95ce6" data-entity-embed-display="view_mode:media.embed" data-entity-embed-display-settings="[]" data-langcode="en" class="embedded-entity"><article class="media media--type-image media--view-mode-embed"> <div class="mb-8 lg:mb-10"> <div class="flex justify-center "> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <picture> <source srcset="/sites/default/files/styles/embed_lg_1x/public/photos/ebola-press-release-fig2.jpg?itok=jWvziJrP 1x, /sites/default/files/styles/embed_lg_2x/public/photos/ebola-press-release-fig2.jpg?itok=vfVGfVt- 2x" media="all and (min-width: 1024px)" type="image/jpeg" width="639" height="479"> <source srcset="/sites/default/files/styles/embed_md/public/photos/ebola-press-release-fig2.jpg?itok=AYR-1VbV 1x, /sites/default/files/styles/embed_md_2x/public/photos/ebola-press-release-fig2.jpg?itok=Py7GZO9e 2x" media="all and (min-width: 768px)" type="image/jpeg" width="865" height="649"> <source srcset="/sites/default/files/styles/embed_sm_1x/public/photos/ebola-press-release-fig2.jpg?itok=Kb6zj7c- 1x, /sites/default/files/styles/embed_sm_2x/public/photos/ebola-press-release-fig2.jpg?itok=X4cX2Cc2 2x" media="all and (min-width: 640px)" type="image/jpeg" width="596" height="447"> <source srcset="/sites/default/files/styles/embed_mobile_1x/public/photos/ebola-press-release-fig2.jpg?itok=R-k2iTT9 1x, /sites/default/files/styles/embed_mobile_2x/public/photos/ebola-press-release-fig2.jpg?itok=_3pdbHu3 2x" type="image/jpeg" width="532" height="399"> <img src="/sites/default/files/styles/embed_lg_1x/public/photos/ebola-press-release-fig2.jpg?itok=jWvziJrP" width="639" height="479" alt loading="lazy" typeof="foaf:Image"> </picture> </div> </div> <div class="media-caption text-sm text-gray-700 mt-4 flex flex-col space-y-1"> <div class="font-body leading-5 md:leading-6 mb-3">Left: A 3D rendering of the cryo-EM reconstruction. The RNA and NP are colored in red and grey, respectively. A single NP molecule is highlighted in blue. Right: An atomic model of a single NP molecule with the RNA in the complex. The model is superposed with the cryo-EM map in a polygon mesh representation.     </div> <div class="leading-5 md:leading-6 text-gray-500"> Yukihiko Sugita </div> </div> </div> </article> </div> </p> <p>“Now that we have a clear picture of what this structure really looks like,” said Prof. Wolf, “it is one step closer to figuring out how the whole virus works”.</p> <p>The three-dimensional model generated from the cryo-EM images provides an accurate foundation for future work. Researchers will now be able to make precisely targeted studies of the entire structure of Ebola virus NC, which may point to ways of defeating the virus.</p> <p> </p> <p> </p> <p> </p> <div id="ritekit-alerts"> </div> <div id="ritekit-alerts"> </div> <div id="ritekit-alerts"> </div> <div id="ritekit-alerts"> </div> <div id="ritekit-alerts"> </div></div></div> </div> </div> </div> </div> <div class="body-and-sidebar-sidebar row-start-3 lg:row-start-1 lg:col-start-2 lg:w-130 lg:flex-none -mx-4 sm:-mx-6 lg:ml-0 lg:-mr-8 xl:-mr-20"> <div class="bg-blue-light-primary text-white w-full flex flex-col space-y-6 py-8 lg:py-12 px-5 lg:px-8 lg:pr-20 print:bg-white print:text-black print:!p-0"> <div class="flex flex-col space-y-3 underline-links print:!text-sm"> <div> <div class="font-body font-bold lg:text-lg print:!text-sm inline">Date: </div> <div class="text-sm lg:text-lg print:!text-sm inline ">17 October 2018</div> </div> <div> <div class="font-body font-bold lg:text-lg print:!text-sm inline">Category: </div> <div class="text-sm lg:text-lg print:!text-sm inline ">Research Update</div> </div> <div> <div class="font-body font-bold lg:text-lg print:!text-sm mb-2">Creator</div> <div class="text-sm lg:text-lg print:!text-sm flex flex-col gap-3"><a href="/creator/tomomi-okubo" hreflang="en">Tomomi Okubo</a></div> </div> </div> <div class="news-article-attributes text-sm lg:text-lg border-t border-gray-300 underline-links print:!text-sm"> <div class="pt-6"> <p class="font-body font-bold mb-3"> Specialties </p> <div class="flex flex-col space-y-3 pl-3"> <a href="/research/specialty/biophysics">Biophysics</a> <a href="/research/specialty/molecular-biology">Molecular biology</a> <a href="/research/specialty/nanoscience">Nanoscience</a> <a href="/research/specialty/structural-biology">Structural biology</a> <a href="/research/specialty/virology">Virology</a> </div> </div> <div class="pt-6"> <p class="font-body font-bold lg:text-lg mb-3 print:!text-sm"> Research Unit </p> <div class="flex flex-col space-y-3 pl-3"> <a class="underline" href="/research/research-units/mcemu">Molecular Cryo-Electron Microscopy Unit</a> </div> </div> </div> <div class="text-sm lg:text-lg border-t border-gray-300 pt-6 print:!text-sm"> <div class="flex flex-col space-y-3"> <p>For press enquiries:<br><a href="https://forms.office.com/r/w8EY7XX5Uk" class="font-body font-bold" target="_blank">Press Inquiry Form</a></p> </div> </div> <div class="border-t border-gray-300 pt-6 print:hidden"> <div class="flex flex-col space-y-4"> <div class="font-bold text-white text-lg">Share on:</div> <div class="flex gap-x-7 items-center"> <a href="//twitter.com/intent/tweet?url=https%3A%2F%2Fwww.oist.jp%2Fnews-center%2Fpress-releases%2Fpicture-perfect-researchers-gain-clearest-ever-image-ebola-virus-protein&text=Picture%20Perfect%3A%20Researchers%20Gain%20Clearest%20Ever%20Image%20of%20Ebola%20Virus%20Protein" rel="external" class="block" target="_blank"> <img class="h-6 w-6" 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href="/news-center/photos/schematic-illustration-ebola-virus-structure" > <div> <figure class="child-object-cover w-full flex-none"> <div class="field field--name-thumbnail field--type-image field--label-hidden field__item"> <picture> <source srcset="/sites/default/files/styles/card_xl_1x/public/photos/ebola-press-release-fig1_en.jpg?h=ddb1ad0c&itok=B_qc6GVj 1x, /sites/default/files/styles/card_xl_2x/public/photos/ebola-press-release-fig1_en.jpg?h=ddb1ad0c&itok=_yetgYQs 2x" media="all and (min-width: 1280px)" type="image/jpeg" width="352" height="204"/> <source srcset="/sites/default/files/styles/card_lg_1x/public/photos/ebola-press-release-fig1_en.jpg?h=ddb1ad0c&itok=8I-HULGP 1x, /sites/default/files/styles/card_lg_2x/public/photos/ebola-press-release-fig1_en.jpg?h=ddb1ad0c&itok=c0OrCRWa 2x" media="all and (min-width: 1024px)" type="image/jpeg" width="331" height="192"/> <source srcset="/sites/default/files/styles/card_md_1x/public/photos/ebola-press-release-fig1_en.jpg?h=ddb1ad0c&itok=xpz9qchD 1x, /sites/default/files/styles/card_md_2x/public/photos/ebola-press-release-fig1_en.jpg?h=ddb1ad0c&itok=B_IOi1FI 2x" media="all and (min-width: 768px)" type="image/jpeg" width="424" height="245"/> <source srcset="/sites/default/files/styles/card_sm_1x/public/photos/ebola-press-release-fig1_en.jpg?h=ddb1ad0c&itok=Ydujtet3 1x, /sites/default/files/styles/card_sm_2x/public/photos/ebola-press-release-fig1_en.jpg?h=ddb1ad0c&itok=VsgDUr24 2x" media="all and (min-width: 640px)" type="image/jpeg" width="296" height="164"/> <source srcset="/sites/default/files/styles/card_mobile_1x/public/photos/ebola-press-release-fig1_en.jpg?h=ddb1ad0c&itok=7ajvD8Wy 1x, /sites/default/files/styles/card_mobile_2x/public/photos/ebola-press-release-fig1_en.jpg?h=ddb1ad0c&itok=ghVFntJ8 2x" type="image/jpeg" width="555" height="308"/> <img src="/sites/default/files/styles/card_lg_1x/public/photos/ebola-press-release-fig1_en.jpg?h=ddb1ad0c&itok=8I-HULGP" width="331" height="192" loading="lazy" typeof="foaf:Image" /> </picture> </div> </figure> <div class="flex flex-col"> <div class="card-type flex flex-row space-x-2 items-center mt-3 lg:mt-2"> <div class="rounded-full h-3.5 w-3.5 min-w-3.5 inline-block bg-avocado-green" style="min-width:.875rem;"></div> <div class="font-body text-xs md:text-sm uppercase text-gray-700">Image</div> </div> <div class="text-sm md:text-base lg:text-lg lg:line-clamp-3 mt-2 font-body font-bold text-gray-900 font-bold">Schematic illustration of the Ebola virus structure</div> <div class="card-text mt-2"> <div class="text-sm md:text-base lg:text-lg text-gray-700 line-clamp-6"> </div> </div> </div> </div> <div class="card-bottom"> </div> </a> </article> </article> <article class="media media--type-image media--view-mode-related-card"> <article class="h-full "> <a class="border-crystal-blue border-2 bg-white flex flex-col justify-between h-full p-4 lg:p-6" href="/news-center/photos/structure-ebola-virus-np-rna-complex" > <div> <figure class="child-object-cover w-full flex-none"> <div class="field field--name-thumbnail field--type-image field--label-hidden field__item"> <picture> <source srcset="/sites/default/files/styles/card_xl_1x/public/photos/ebola-press-release-fig2.jpg?h=ddb1ad0c&itok=ViCoR9fO 1x, /sites/default/files/styles/card_xl_2x/public/photos/ebola-press-release-fig2.jpg?h=ddb1ad0c&itok=Xp7-hJP- 2x" media="all and (min-width: 1280px)" type="image/jpeg" width="352" height="204"/> <source srcset="/sites/default/files/styles/card_lg_1x/public/photos/ebola-press-release-fig2.jpg?h=ddb1ad0c&itok=095ydrEG 1x, /sites/default/files/styles/card_lg_2x/public/photos/ebola-press-release-fig2.jpg?h=ddb1ad0c&itok=m9cgH5sV 2x" media="all and (min-width: 1024px)" type="image/jpeg" width="331" height="192"/> <source srcset="/sites/default/files/styles/card_md_1x/public/photos/ebola-press-release-fig2.jpg?h=ddb1ad0c&itok=30Fmx1XV 1x, /sites/default/files/styles/card_md_2x/public/photos/ebola-press-release-fig2.jpg?h=ddb1ad0c&itok=h_QRjR_r 2x" media="all and (min-width: 768px)" type="image/jpeg" width="424" height="245"/> <source srcset="/sites/default/files/styles/card_sm_1x/public/photos/ebola-press-release-fig2.jpg?h=ddb1ad0c&itok=LBXOM18f 1x, /sites/default/files/styles/card_sm_2x/public/photos/ebola-press-release-fig2.jpg?h=ddb1ad0c&itok=oWtCiAEr 2x" media="all and (min-width: 640px)" type="image/jpeg" width="296" height="164"/> <source srcset="/sites/default/files/styles/card_mobile_1x/public/photos/ebola-press-release-fig2.jpg?h=ddb1ad0c&itok=3lMfoY1u 1x, /sites/default/files/styles/card_mobile_2x/public/photos/ebola-press-release-fig2.jpg?h=ddb1ad0c&itok=WBV471tY 2x" type="image/jpeg" width="555" height="308"/> <img src="/sites/default/files/styles/card_lg_1x/public/photos/ebola-press-release-fig2.jpg?h=ddb1ad0c&itok=095ydrEG" width="331" height="192" loading="lazy" typeof="foaf:Image" /> </picture> </div> </figure> <div class="flex flex-col"> <div class="card-type flex flex-row space-x-2 items-center mt-3 lg:mt-2"> <div class="rounded-full h-3.5 w-3.5 min-w-3.5 inline-block bg-avocado-green" style="min-width:.875rem;"></div> <div class="font-body text-xs md:text-sm uppercase text-gray-700">Image</div> </div> <div class="text-sm md:text-base lg:text-lg lg:line-clamp-3 mt-2 font-body font-bold text-gray-900 font-bold">Structure of the Ebola virus NP-RNA complex</div> <div class="card-text mt-2"> <div class="text-sm md:text-base lg:text-lg text-gray-700 line-clamp-6"> </div> </div> </div> </div> <div class="card-bottom"> </div> </a> </article> </article> <article class="media media--type-image media--view-mode-related-card"> <article class="h-full "> <a class="border-crystal-blue border-2 bg-white flex flex-col justify-between h-full p-4 lg:p-6" href="/news-center/photos/ebola-virus-particles-host-cell" > <div> <figure class="child-object-cover w-full flex-none"> <div class="field field--name-thumbnail field--type-image field--label-hidden field__item"> <picture> <source srcset="/sites/default/files/styles/card_xl_1x/public/photos/ebola-press-release-SEM-virus.jpg?h=e42735e8&itok=rjfqEk09 1x, /sites/default/files/styles/card_xl_2x/public/photos/ebola-press-release-SEM-virus.jpg?h=e42735e8&itok=FrTsGKQ5 2x" media="all and (min-width: 1280px)" type="image/jpeg" width="352" height="204"/> <source srcset="/sites/default/files/styles/card_lg_1x/public/photos/ebola-press-release-SEM-virus.jpg?h=e42735e8&itok=EMyJTnu7 1x, /sites/default/files/styles/card_lg_2x/public/photos/ebola-press-release-SEM-virus.jpg?h=e42735e8&itok=FqbavjPv 2x" media="all and (min-width: 1024px)" type="image/jpeg" width="331" height="192"/> <source srcset="/sites/default/files/styles/card_md_1x/public/photos/ebola-press-release-SEM-virus.jpg?h=e42735e8&itok=RCq90hWj 1x, /sites/default/files/styles/card_md_2x/public/photos/ebola-press-release-SEM-virus.jpg?h=e42735e8&itok=tdB969q_ 2x" media="all and (min-width: 768px)" type="image/jpeg" width="424" height="245"/> <source srcset="/sites/default/files/styles/card_sm_1x/public/photos/ebola-press-release-SEM-virus.jpg?h=e42735e8&itok=7IOV8LN2 1x, /sites/default/files/styles/card_sm_2x/public/photos/ebola-press-release-SEM-virus.jpg?h=e42735e8&itok=DtxwtZPa 2x" media="all and (min-width: 640px)" type="image/jpeg" width="296" height="164"/> <source srcset="/sites/default/files/styles/card_mobile_1x/public/photos/ebola-press-release-SEM-virus.jpg?h=e42735e8&itok=UZQGdczk 1x, /sites/default/files/styles/card_mobile_2x/public/photos/ebola-press-release-SEM-virus.jpg?h=e42735e8&itok=UUabxNKV 2x" type="image/jpeg" width="555" height="308"/> <img src="/sites/default/files/styles/card_lg_1x/public/photos/ebola-press-release-SEM-virus.jpg?h=e42735e8&itok=EMyJTnu7" width="331" height="192" loading="lazy" typeof="foaf:Image" /> </picture> </div> </figure> <div class="flex flex-col"> <div class="card-type flex flex-row space-x-2 items-center mt-3 lg:mt-2"> <div class="rounded-full h-3.5 w-3.5 min-w-3.5 inline-block bg-avocado-green" style="min-width:.875rem;"></div> <div class="font-body text-xs md:text-sm uppercase text-gray-700">Image</div> </div> <div class="text-sm md:text-base lg:text-lg lg:line-clamp-3 mt-2 font-body font-bold text-gray-900 font-bold">Ebola virus particles on a host cell</div> <div class="card-text mt-2"> <div class="text-sm md:text-base lg:text-lg text-gray-700 line-clamp-6"> </div> </div> </div> </div> <div class="card-bottom"> </div> </a> </article> </article> <article class="media media--type-image media--view-mode-related-card"> <article class="h-full "> <a class="border-crystal-blue border-2 bg-white flex flex-col justify-between h-full p-4 lg:p-6" href="/news-center/photos/dr-yukihiko-sugita-prof-matthias-wolf" > <div> <figure class="child-object-cover w-full flex-none"> <div class="field field--name-thumbnail field--type-image field--label-hidden field__item"> <picture> <source srcset="/sites/default/files/styles/card_xl_1x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?h=078bd7aa&itok=wttb1CmU 1x, /sites/default/files/styles/card_xl_2x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?h=078bd7aa&itok=QKt-Jdd5 2x" media="all and (min-width: 1280px)" type="image/jpeg" width="352" height="204"/> <source srcset="/sites/default/files/styles/card_lg_1x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?h=078bd7aa&itok=BGRXJBfR 1x, /sites/default/files/styles/card_lg_2x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?h=078bd7aa&itok=G_k0Ar1z 2x" media="all and (min-width: 1024px)" type="image/jpeg" width="331" height="192"/> <source srcset="/sites/default/files/styles/card_md_1x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?h=078bd7aa&itok=UClYrb7n 1x, /sites/default/files/styles/card_md_2x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?h=078bd7aa&itok=FZDHlte2 2x" media="all and (min-width: 768px)" type="image/jpeg" width="424" height="245"/> <source srcset="/sites/default/files/styles/card_sm_1x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?h=078bd7aa&itok=eWlj52Qc 1x, /sites/default/files/styles/card_sm_2x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?h=078bd7aa&itok=cxmtAgu0 2x" media="all and (min-width: 640px)" type="image/jpeg" width="296" height="164"/> <source srcset="/sites/default/files/styles/card_mobile_1x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?h=078bd7aa&itok=Svh7-At2 1x, /sites/default/files/styles/card_mobile_2x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?h=078bd7aa&itok=hlxyugsp 2x" type="image/jpeg" width="555" height="308"/> <img src="/sites/default/files/styles/card_lg_1x/public/photos/ebola-press-release-yuki-sugita-matthias-wolf.jpg?h=078bd7aa&itok=BGRXJBfR" width="331" height="192" loading="lazy" typeof="foaf:Image" /> </picture> </div> </figure> <div class="flex flex-col"> <div class="card-type flex flex-row space-x-2 items-center mt-3 lg:mt-2"> <div class="rounded-full h-3.5 w-3.5 min-w-3.5 inline-block bg-avocado-green" style="min-width:.875rem;"></div> <div class="font-body text-xs md:text-sm uppercase text-gray-700">Image</div> </div> <div class="text-sm md:text-base lg:text-lg lg:line-clamp-3 mt-2 font-body font-bold text-gray-900 font-bold">Dr. Yukihiko Sugita & Prof. Matthias Wolf</div> <div class="card-text mt-2"> <div class="text-sm md:text-base lg:text-lg text-gray-700 line-clamp-6"> </div> </div> </div> </div> <div class="card-bottom"> </div> </a> </article> </article> <article class="media media--type-video media--view-mode-related-card"> <article class="h-full "> <a class="border-crystal-blue border-2 bg-white flex flex-col justify-between h-full p-4 lg:p-6" href="/news-center/videos/nucleocapsid-video" > <div> <figure class="child-object-cover w-full flex-none"> <div class="field field--name-thumbnail field--type-image field--label-hidden field__item"> <picture> <source srcset="/sites/default/files/styles/card_xl_1x/public/oembed_thumbnails/v-gJ9DAmVuI9QdllwIAEseVIAOUoAnEiwL-LSzALgFs.jpg?h=7a6e80fd&itok=5IxgUTRK 1x, /sites/default/files/styles/card_xl_2x/public/oembed_thumbnails/v-gJ9DAmVuI9QdllwIAEseVIAOUoAnEiwL-LSzALgFs.jpg?h=7a6e80fd&itok=zdb93o4Z 2x" media="all and (min-width: 1280px)" type="image/jpeg" width="352" height="204"/> <source srcset="/sites/default/files/styles/card_lg_1x/public/oembed_thumbnails/v-gJ9DAmVuI9QdllwIAEseVIAOUoAnEiwL-LSzALgFs.jpg?h=7a6e80fd&itok=ooxfTI3Z 1x, /sites/default/files/styles/card_lg_2x/public/oembed_thumbnails/v-gJ9DAmVuI9QdllwIAEseVIAOUoAnEiwL-LSzALgFs.jpg?h=7a6e80fd&itok=7LtrF0yL 2x" media="all and (min-width: 1024px)" type="image/jpeg" width="331" height="192"/> <source srcset="/sites/default/files/styles/card_md_1x/public/oembed_thumbnails/v-gJ9DAmVuI9QdllwIAEseVIAOUoAnEiwL-LSzALgFs.jpg?h=7a6e80fd&itok=p4DTB4XB 1x, /sites/default/files/styles/card_md_2x/public/oembed_thumbnails/v-gJ9DAmVuI9QdllwIAEseVIAOUoAnEiwL-LSzALgFs.jpg?h=7a6e80fd&itok=sSpO9tDo 2x" media="all and (min-width: 768px)" type="image/jpeg" width="424" height="245"/> <source srcset="/sites/default/files/styles/card_sm_1x/public/oembed_thumbnails/v-gJ9DAmVuI9QdllwIAEseVIAOUoAnEiwL-LSzALgFs.jpg?h=7a6e80fd&itok=Jr5mXFej 1x, /sites/default/files/styles/card_sm_2x/public/oembed_thumbnails/v-gJ9DAmVuI9QdllwIAEseVIAOUoAnEiwL-LSzALgFs.jpg?h=7a6e80fd&itok=Db9R1HVl 2x" media="all and (min-width: 640px)" type="image/jpeg" width="296" height="164"/> <source srcset="/sites/default/files/styles/card_mobile_1x/public/oembed_thumbnails/v-gJ9DAmVuI9QdllwIAEseVIAOUoAnEiwL-LSzALgFs.jpg?h=7a6e80fd&itok=RQXkHNeA 1x, /sites/default/files/styles/card_mobile_2x/public/oembed_thumbnails/v-gJ9DAmVuI9QdllwIAEseVIAOUoAnEiwL-LSzALgFs.jpg?h=7a6e80fd&itok=AA4zMkSX 2x" type="image/jpeg" width="555" height="308"/> <img src="/sites/default/files/styles/card_lg_1x/public/oembed_thumbnails/v-gJ9DAmVuI9QdllwIAEseVIAOUoAnEiwL-LSzALgFs.jpg?h=7a6e80fd&itok=ooxfTI3Z" width="331" height="192" alt="" loading="lazy" typeof="foaf:Image" /> </picture> </div> </figure> <div class="flex flex-col"> <div class="card-type flex flex-row space-x-2 items-center mt-3 lg:mt-2"> <div class="rounded-full h-3.5 w-3.5 min-w-3.5 inline-block bg-poppy-red" style="min-width:.875rem;"></div> <div class="font-body text-xs md:text-sm uppercase text-gray-700">Video</div> </div> <div class="text-sm md:text-base lg:text-lg lg:line-clamp-3 mt-2 font-body font-bold text-gray-900 font-bold">Nucleocapsid Video</div> <div class="card-text mt-2"> <div class="text-sm md:text-base lg:text-lg text-gray-700 line-clamp-6"> </div> </div> </div> </div> <div class="card-bottom"> </div> </a> </article> </article> </div> </div> <div id="paragraph-" class="paragraph featured-content-grid bg-blue-light-primary py-8 lg:py-15 print:hidden"> <div class="px-4 sm:container-wide"> <h2 class="font-header text-2xl md:text-5xl md:leading-16 lg:text-6xl lg:leading-20 text-center text-white mb-8 lg:mb-15"> <budoux-ja>Related News</budoux-ja> </h2> </div> <div class="sm:container-wide"> <div class=" carousel-wrapper carousel-dots carousel-fixed-width-on-mobile carousel-dots--outside carousel-center-mode-mobile carousel-responsive xl:px-0" data-slides-to-scroll="1" data-slides-laptop="3"> <div class="w-70 sm:w-auto carousel-slide h-full "> <div class="h-full bg-white p-3 max-w-full w-full lg:p-6"><article class="h-full"> <a class="border-yellow border bg-white flex flex-col h-full " href="/news-center/news/2020/10/15/oist-antibody-test-required-interdisciplinary-approach"> <figure class="child-object-cover w-full flex-none "> <picture> <source srcset="/sites/default/files/styles/featured_card_xl_1x/public/CoverImage_2.jpg?h=26db3081&itok=O9COwjJo 1x, /sites/default/files/styles/featured_card_xl_2x/public/CoverImage_2.jpg?h=26db3081&itok=KauhzfDM 2x" media="all and (min-width: 1280px)" type="image/jpeg" width="352" height="204"/> <source srcset="/sites/default/files/styles/featured_card_lg_1x/public/CoverImage_2.jpg?h=26db3081&itok=m2FtHR7u 1x, /sites/default/files/styles/featured_card_lg_2x/public/CoverImage_2.jpg?h=26db3081&itok=CqkAHf06 2x" media="all and (min-width: 1024px)" type="image/jpeg" width="329" height="182"/> <source srcset="/sites/default/files/styles/featured_card_md_1x/public/CoverImage_2.jpg?h=26db3081&itok=kIKqHHbv 1x, /sites/default/files/styles/featured_card_md_2x/public/CoverImage_2.jpg?h=26db3081&itok=6RsT8jsD 2x" media="all and (min-width: 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class="rounded-full h-3.5 w-3.5 inline-block bg-yellow"></div> <div class="font-body text-xs md:text-sm uppercase text-gray-700">Research Update</div> </div> <h3 class="font-body md:text-lg text-gray-900 font-bold leading-6 lg:line-clamp-3">The OIST antibody test required an interdisciplinary approach</h3> <div class="card-text"> <div class="text-gray-900 text-lg line-clamp-4"> Scientists and staff across OIST have worked hard over the last few months to test the OIST community for antibodies against SARS-CoV-2, the virus that causes COVID-19. </div> </div> </div> </a> </article> </div> </div> <div class="w-70 sm:w-auto carousel-slide h-full "> <div class="h-full bg-white p-3 max-w-full w-full lg:p-6"><article class="h-full"> <a class="border-yellow border bg-white flex flex-col h-full " href="/news-center/news/2019/10/1/flagellar-hook-making-sense-bacterial-motility"> <figure class="child-object-cover w-full flex-none "> <picture> <source srcset="/sites/default/files/styles/featured_card_xl_1x/public/20190827-flagellum-banner.jpg?h=14f0de79&itok=A7sf0DZC 1x, /sites/default/files/styles/featured_card_xl_2x/public/20190827-flagellum-banner.jpg?h=14f0de79&itok=wYdfToLu 2x" media="all and (min-width: 1280px)" type="image/jpeg" width="352" height="204"/> <source srcset="/sites/default/files/styles/featured_card_lg_1x/public/20190827-flagellum-banner.jpg?h=14f0de79&itok=nHlQIe98 1x, /sites/default/files/styles/featured_card_lg_2x/public/20190827-flagellum-banner.jpg?h=14f0de79&itok=dJIcmFXA 2x" media="all and (min-width: 1024px)" type="image/jpeg" width="329" height="182"/> <source srcset="/sites/default/files/styles/featured_card_md_1x/public/20190827-flagellum-banner.jpg?h=14f0de79&itok=0o6j_Jbl 1x, /sites/default/files/styles/featured_card_md_2x/public/20190827-flagellum-banner.jpg?h=14f0de79&itok=p95Oolw2 2x" media="all and (min-width: 768px)" type="image/jpeg" width="438" height="243"/> <source srcset="/sites/default/files/styles/featured_card_sm_1x/public/20190827-flagellum-banner.jpg?h=14f0de79&itok=_QBsAtCL 1x, /sites/default/files/styles/featured_card_sm_2x/public/20190827-flagellum-banner.jpg?h=14f0de79&itok=6c9fhueN 2x" media="all and (min-width: 640px)" type="image/jpeg" width="310" height="172"/> <source srcset="/sites/default/files/styles/featured_card_mobile_1x/public/20190827-flagellum-banner.jpg?h=14f0de79&itok=5BeqVgjf 1x, /sites/default/files/styles/featured_card_mobile_2x/public/20190827-flagellum-banner.jpg?h=14f0de79&itok=q54a-2U- 2x" type="image/jpeg" width="256" height="170"/> <img src="/sites/default/files/styles/featured_card_xl_1x/public/20190827-flagellum-banner.jpg?h=14f0de79&itok=A7sf0DZC" width="352" height="204" alt="" loading="lazy" typeof="foaf:Image" /> </picture> </figure> <div class="pt-3.5 lg:pt-3 px-2 pb-3.5 lg:pb-6 lg:px-6 flex flex-col space-y-3.5 "> <div class="card-type flex flex-row space-x-1.5 items-center"> <div class="rounded-full h-3.5 w-3.5 inline-block bg-yellow"></div> <div class="font-body text-xs md:text-sm uppercase text-gray-700">Research Update</div> </div> <h3 class="font-body md:text-lg text-gray-900 font-bold leading-6 lg:line-clamp-3">The Flagellar Hook: Making Sense of Bacterial Motility</h3> <div class="card-text"> <div class="text-gray-900 text-lg line-clamp-4"> Cryogenic electron microscopy reveals how the flagellar hook transmits movement. </div> </div> </div> </a> </article> </div> </div> <div class="w-70 sm:w-auto carousel-slide h-full "> <div class="h-full bg-white p-3 max-w-full w-full lg:p-6"><article class="h-full"> <a class="border-yellow border bg-white flex flex-col h-full " href="/news-center/press-releases/anti-cancer-virus-fits-tumor-receptor-%E2%80%9Ckey-lock%E2%80%9D"> <figure class="child-object-cover w-full flex-none "> <picture> <source srcset="/sites/default/files/styles/featured_card_xl_1x/public/PossibleHeaderSVV4.jpg?h=14f0de79&itok=qIEnfvWX 1x, /sites/default/files/styles/featured_card_xl_2x/public/PossibleHeaderSVV4.jpg?h=14f0de79&itok=mke10bAa 2x" media="all and (min-width: 1280px)" type="image/jpeg" width="352" height="204"/> <source srcset="/sites/default/files/styles/featured_card_lg_1x/public/PossibleHeaderSVV4.jpg?h=14f0de79&itok=lnpKse8v 1x, /sites/default/files/styles/featured_card_lg_2x/public/PossibleHeaderSVV4.jpg?h=14f0de79&itok=zgDFjpk6 2x" media="all and (min-width: 1024px)" type="image/jpeg" width="329" height="182"/> <source srcset="/sites/default/files/styles/featured_card_md_1x/public/PossibleHeaderSVV4.jpg?h=14f0de79&itok=3Z_bVbGC 1x, /sites/default/files/styles/featured_card_md_2x/public/PossibleHeaderSVV4.jpg?h=14f0de79&itok=ulaN8Ph6 2x" media="all and (min-width: 768px)" type="image/jpeg" width="438" height="243"/> <source srcset="/sites/default/files/styles/featured_card_sm_1x/public/PossibleHeaderSVV4.jpg?h=14f0de79&itok=KYv2fJip 1x, /sites/default/files/styles/featured_card_sm_2x/public/PossibleHeaderSVV4.jpg?h=14f0de79&itok=hHnZJLW9 2x" media="all and (min-width: 640px)" type="image/jpeg" width="310" height="172"/> <source srcset="/sites/default/files/styles/featured_card_mobile_1x/public/PossibleHeaderSVV4.jpg?h=14f0de79&itok=2YwxWo4K 1x, /sites/default/files/styles/featured_card_mobile_2x/public/PossibleHeaderSVV4.jpg?h=14f0de79&itok=RqQ_vj8h 2x" type="image/jpeg" width="256" height="170"/> <img src="/sites/default/files/styles/featured_card_xl_1x/public/PossibleHeaderSVV4.jpg?h=14f0de79&itok=qIEnfvWX" width="352" height="204" alt="" loading="lazy" typeof="foaf:Image" /> </picture> </figure> <div class="pt-3.5 lg:pt-3 px-2 pb-3.5 lg:pb-6 lg:px-6 flex flex-col space-y-3.5 "> <div class="card-type flex flex-row space-x-1.5 items-center"> <div class="rounded-full h-3.5 w-3.5 inline-block bg-yellow"></div> <div class="font-body text-xs md:text-sm uppercase text-gray-700">Research Update</div> </div> <h3 class="font-body md:text-lg text-gray-900 font-bold leading-6 lg:line-clamp-3">Anti-Cancer Virus Fits Tumor Receptor Like a “Key in a Lock” </h3> <div class="card-text"> <div class="text-gray-900 text-lg line-clamp-4"> For the first time, scientists reveal how a promising drug candidate for cancer therapy interacts with receptors on tumors. </div> </div> </div> </a> </article> </div> </div> <div class="w-70 sm:w-auto carousel-slide h-full "> <div class="h-full bg-white p-3 max-w-full w-full lg:p-6"><article class="h-full"> <a class="border-yellow border bg-white flex flex-col h-full " href="/news-center/news/2022/3/31/scaffold-twist-cryo-em-reveals-building-blocks-poxvirus"> <figure class="child-object-cover w-full flex-none "> <picture> <source srcset="/sites/default/files/styles/featured_card_xl_1x/public/20220330-header.png?h=0cdbaf97&itok=9a4S4Xbg 1x, /sites/default/files/styles/featured_card_xl_2x/public/20220330-header.png?h=0cdbaf97&itok=oZFRj4oB 2x" media="all and (min-width: 1280px)" type="image/png" width="352" height="204"/> <source srcset="/sites/default/files/styles/featured_card_lg_1x/public/20220330-header.png?h=0cdbaf97&itok=ACjs_IvR 1x, /sites/default/files/styles/featured_card_lg_2x/public/20220330-header.png?h=0cdbaf97&itok=Qpu103e9 2x" media="all and (min-width: 1024px)" type="image/png" width="329" height="182"/> <source srcset="/sites/default/files/styles/featured_card_md_1x/public/20220330-header.png?h=0cdbaf97&itok=0jDQvElv 1x, /sites/default/files/styles/featured_card_md_2x/public/20220330-header.png?h=0cdbaf97&itok=NIf84Hpi 2x" media="all and (min-width: 768px)" type="image/png" width="438" height="243"/> <source srcset="/sites/default/files/styles/featured_card_sm_1x/public/20220330-header.png?h=0cdbaf97&itok=-xxDRS8m 1x, /sites/default/files/styles/featured_card_sm_2x/public/20220330-header.png?h=0cdbaf97&itok=Js5E9f83 2x" media="all and (min-width: 640px)" type="image/png" width="310" height="172"/> <source srcset="/sites/default/files/styles/featured_card_mobile_1x/public/20220330-header.png?h=0cdbaf97&itok=dOI2qVhX 1x, /sites/default/files/styles/featured_card_mobile_2x/public/20220330-header.png?h=0cdbaf97&itok=f2uYPiTZ 2x" type="image/png" width="256" height="170"/> <img src="/sites/default/files/styles/featured_card_xl_1x/public/20220330-header.png?h=0cdbaf97&itok=9a4S4Xbg" width="352" height="204" alt="" loading="lazy" typeof="foaf:Image" /> </picture> </figure> <div class="pt-3.5 lg:pt-3 px-2 pb-3.5 lg:pb-6 lg:px-6 flex flex-col space-y-3.5 "> <div class="card-type flex flex-row space-x-1.5 items-center"> <div class="rounded-full h-3.5 w-3.5 inline-block bg-yellow"></div> <div class="font-body text-xs md:text-sm uppercase text-gray-700">Research Update</div> </div> <h3 class="font-body md:text-lg text-gray-900 font-bold leading-6 lg:line-clamp-3">A scaffold with a twist: Cryo-EM reveals the building blocks of poxvirus</h3> <div class="card-text"> <div class="text-gray-900 text-lg line-clamp-4"> Researchers uncover how poxviruses form their protein scaffold from a building block called D13, which could lead to the development of new antiviral drugs. </div> </div> </div> </a> </article> </div> </div> <div class="w-70 sm:w-auto carousel-slide h-full "> <div class="h-full bg-white p-3 max-w-full w-full lg:p-6"><article class="h-full"> <a class="border-yellow border bg-white flex flex-col h-full " href="/news-center/news/2012/6/6/new-unit-profile-beautiful-viruses"> <figure class="child-object-cover w-full flex-none "> <picture> <source srcset="/sites/default/files/styles/featured_card_xl_1x/public/photos/HPV1_0.JPG?h=50ebdd74&itok=Lqf_zi5T 1x, /sites/default/files/styles/featured_card_xl_2x/public/photos/HPV1_0.JPG?h=50ebdd74&itok=HynhoqYQ 2x" media="all and (min-width: 1280px)" type="image/jpeg" width="352" height="204"/> <source srcset="/sites/default/files/styles/featured_card_lg_1x/public/photos/HPV1_0.JPG?h=50ebdd74&itok=0IwPyjxH 1x, /sites/default/files/styles/featured_card_lg_2x/public/photos/HPV1_0.JPG?h=50ebdd74&itok=PFmKdqOF 2x" media="all and (min-width: 1024px)" type="image/jpeg" width="329" height="182"/> <source srcset="/sites/default/files/styles/featured_card_md_1x/public/photos/HPV1_0.JPG?h=50ebdd74&itok=0GaHH8H3 1x, /sites/default/files/styles/featured_card_md_2x/public/photos/HPV1_0.JPG?h=50ebdd74&itok=woyvPkRh 2x" media="all and (min-width: 768px)" type="image/jpeg" width="438" height="243"/> <source srcset="/sites/default/files/styles/featured_card_sm_1x/public/photos/HPV1_0.JPG?h=50ebdd74&itok=J874WQbx 1x, /sites/default/files/styles/featured_card_sm_2x/public/photos/HPV1_0.JPG?h=50ebdd74&itok=9XbV4ns_ 2x" media="all and (min-width: 640px)" type="image/jpeg" width="310" height="172"/> <source srcset="/sites/default/files/styles/featured_card_mobile_1x/public/photos/HPV1_0.JPG?h=50ebdd74&itok=p51-YZMN 1x, /sites/default/files/styles/featured_card_mobile_2x/public/photos/HPV1_0.JPG?h=50ebdd74&itok=rFCulN8R 2x" type="image/jpeg" width="256" height="170"/> <img src="/sites/default/files/styles/featured_card_xl_1x/public/photos/HPV1_0.JPG?h=50ebdd74&itok=Lqf_zi5T" width="352" height="204" alt="" loading="lazy" typeof="foaf:Image" /> </picture> </figure> <div class="pt-3.5 lg:pt-3 px-2 pb-3.5 lg:pb-6 lg:px-6 flex flex-col space-y-3.5 "> <div class="card-type flex flex-row space-x-1.5 items-center"> <div class="rounded-full h-3.5 w-3.5 inline-block bg-yellow"></div> <div class="font-body text-xs md:text-sm uppercase text-gray-700">Research Update</div> </div> <h3 class="font-body md:text-lg text-gray-900 font-bold leading-6 lg:line-clamp-3">New Unit Profile: Beautiful Viruses</h3> <div class="card-text"> <div class="text-gray-900 text-lg line-clamp-4"> Using the papilloma and polyoma viruses as subjects, Prof. Matthias Wolf’s team is focusing on how viruses latch on to cells, poke holes in 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